Supported by an educational grant from Merck & Co., Inc.

Jointly provided by Center for Independent Healthcare Education and Vemco MedEd

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Tuesday, June 6, 20176:15 – 6:45 PM

Registration and Dinner6:45 – 8:45 PM

Educational Program

Sheraton Boston Hotel

39 Dalton Street Boston, MA Meeting Room: Grand Ballroom

Please join us for a CME Satellite Symposium held in conjunction with SLEEP 2017

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6:15 – 6:45 PM Registration and Buffet Dinner 6:45 – 8:45 PM Educational Program 6:45 – 7:00 PM Welcome and Introduction

7:00 – 7:30 PM Normal Sleep Physiology and Its Implications in Insomnia Pathophysiology Phyllis C. Zee, MD, PhD

  7:30 – 8:00 PM Personalization of Insomnia Therapy: Matching Treatment with Patient Needs Andrew Krystal, MD, MS

  8:00 – 8:30 PM Unique Role of Orexin Receptor Antagonists in Insomnia Management: Mechanism and Clinical Implications Thomas Roth, PhD

8:30 – 8:45 PM Learning By Sharing: Q and A

1. Please go to www.vemcomeded.com and select “Register for Programs” or call 908-704-2400.

2. Email your name, affiliation, and mailing address to cme@vemcomeded.com

3. Use a QR Code Reader on your mobile device to register online by scanning the image.

There is no registration fee to attend this continuing education activity.

Educational OverviewInsomnia is a widely-prevalent disorder, with up to 40% of adults experiencing some symptoms and approximately 10% with a clinical diagnosis. Although insomnia is a prevalent and serious problem, it is underdiagnosed and undertreated. The impact of insomnia is substantial, resulting in reduced quality of life and increasing risk of comorbid conditions, such as depression, anxiety, obesity, type 2 diabetes, and cardiovascular disease. Recently, there have been several advances in the understanding of sleep physiology, including the role of orexin in controlling the sleep-wake cycle. A better understanding of the pathophysiology of sleep disorders has led to new research in identifying targets for possible treatment. In particular, orexin receptor antagonists offer a unique mechanism of action and have been shown to be an effective option in managing insomnia. Appropriate management of insomnia requires clinicians to have a thorough understanding of current medications available and how they can be used in a patient-centric manner to best meet their needs and preferences. This program will provide an overview of the current understanding of the sleep-wake cycle and how disruptions to that cycle can cause sleep disorders. The mechanism and clinical implications of orexin receptor antagonists as part of the insomnia management plan will also be discussed.

Target AudienceThis continuing medical education activity is planned to meet the needs of sleep specialists who are involved in the diagnosis, evaluation, and treatment of patients with insomnia. These include physicians, researchers, sleep technologists, and other professionals who specialize in sleep medicine, neurology, psychology, psychiatry, and neurophysiology.

Learning ObjectivesUpon completing this activity, participants will be able to:• Understand the latest advancements in the pathophysiology of sleep disorders• Recognize the latest non-pharmacologic and pharmacologic approaches in

controlling the sleep-wake cycle • Evaluate the use of orexin receptor antagonists in the management of insomnia

Accreditation | Physicians

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education through the joint providership of Center for Independent Healthcare Education (Center) and Vemco MedEd. Center is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Center designates this live activity for a maximum of 2.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosures of Conflict of Interest

Center for Independent Healthcare Education and Vemco MedEd require faculty, planners, and others who are in a position to control the content of continuing education activities to disclose to the audience any real or apparent conflict of interest related to the activity. All identified conflicts of interest are reviewed and resolved to ensure fair balance, objectivity, and scientific rigor in all activities. The faculty is further required to disclose discussion of off-label uses in their presentations.

Arrangements for Special Assistance

Vemco MedEd and Center for Independent Healthcare Education fully comply with the Americans With Disabilities Act. Please submit a written request at least 5 days prior to the meeting, and we will be glad to assist you with any special needs required to make this program accessible to you. Please email your request to cme@vemcomeded.com.

Sheraton Boston Hotel Meeting Room: Grand BallroomAgenda

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