Early onset narcolepsy

Fang Han M.D.Department of Medicine, People’s Hospital

Peking University, China

Child Narcolepsy in Chinese: an old disease

1999 2000 2001 2002 2003patie

nt n

umbe

rs p

er 6

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clin

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isito

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2022242628303234363840

23 22

26

33

38

Incidence of childhood narcolepsy during 5-year follow-upin a neurological clinic in Beijing Children’s Hospital

It is estimated that the incidence of childhood narcolepsy was between 0.04%-0.063% in a pediatric neurology clinic during 5-year follow-up. This is equivalent to the prevalence of adult patients in Hongkong Chinese.

Wing YK, et al. 2001

Area distribution of Narcolepsy

BJ 184

JS 10

LN 23

SD 27 SX 27

SC 6

TJ 7

JL 12

QH 2

HB 95

HN 37

AH 7HUB 3

SX 10

GS 2

XJ 2

HLJ 20

Tibet 2

NMG 27

ZJ 5

SH 5

HN 3

YN 3 GD 3

NX 5

JX 1

FJ 1

GZ 2

This lab has 70-80% (total around 700) diagnosed narcolepsy in China300/700 had onset <10 Year old

Pat

ient

Num

ber

020406080

100120140160180 Chinese n=462

Japanese n=465

AGE OF ONSET

Between Sep. 1998 to Sep. 2007, 580 patients diagnosed as narcolepsy, and the data of 462 is presented

• Early on set narcolepsy has more severe daytime sleepiness and high rate of cataplexy, and MSLT testing showed more SOREMs.

• More familial effect indicated that genetic effect might play a more important role in the development of symptoms in early onset narcoleptics