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RESPON METABOLISME
PADA STARVASI DAN STRES
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PUSAT PENGATURAN ASUPAN
MAKAN
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METABOLIC PROFILE OF ORGANS
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THE LIVER ASTHE LIVER AS
CENTRAL PLAYER CENTRAL PLAYER
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PATHWAY APA??
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FLOW SUBSTRAT
DURING FASTING AND
STARVATION STATE
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PATHWAY APA?
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SIKLUS APA?
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PATHWAY OF AMINO ACID
METABOLISM IN THE
LIVER
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POSTABSORPTIVE STATE -> AFTER A MEAL
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Blood-glucose level dropsafter several hours afterthe meal
- > decrease in insulinsecretion
-> rise in glucagon
secretion Low blood-glucose level
-> stimulates glucagonsecretion of α-cells of thepancreas
EARLY FASTING STATE
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FIRST PRIORITY
-> provide sufcient glucose to brain and other tissues that aredependent on it
SECOND PRIORITY
-> preserve protein
-> shit rom utilization o glucose to utilization o atty acids + ketonebodies
-> mobilization o TAG in adipose tissues + gluconeogenesis by liver
-> muscle shit rom glucose to atty acids as uel
AFTER 3 DAYS OF STARVATION
-> liver orms large amounts o ketone bodies
-> brain and heart start to use ketone bodies as uel
AFTER SEVERAL WEEKS OF STARVATION
-> ketone bodies major uel o brain
AFTER DEPLETION OF TAG STORES
-> proteins degradation accelerates
PROLONGED STARVATION
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