March– April 2017 | Volume 17 Number 6

USF DEPARTMENT OF PEDIATRICS

FROM THE CHAIR This is a great time of the year when we celebrate our students and residents, recognize their accomplishments and mark their transition to the next level. At MCOM graduation this week 164 students received their MD degree. Everyone in Pediatrics should feel a sense of pride in this milestone for we all play a part—some large, some small— in their education.

The commencement speaker this year was Victor Dzau, President of the National Academy of Medicine (formerly IOM), and former Chancellor of Health Affairs at Duke University and President and CEO of the Duke University Medical Center. Dr. Dzau gave an inspirational message to the graduates about the importance of science and evidence, and the critical need for healthcare leaders to fight to maintain their place in our society. Scientific evidence should inform not only our care delivery but our health policies. Dr. Dzau gave a charge to the graduates to be active in promoting science. As providers, we are fighting fake news every day— each time we counsel a parent who wants to refuse a vaccine, or dispel an

Inspired by Our Community – Powered by Our University Department of Pediatrics | University of South Florida | 2 Tampa General Circle | Tampa, FL 33606

FELLOWS & RESIDENTS FORUM

On April 27 USF Peds fellows will present their research at the Fellows Forum,

to be held from 9:30 AM to 12:15 PM in room 5051 of the STC. The Forum will

be followed by a networking luncheon, during which the residents’ quality

improvement posters will be on display. The Resident Forum will be held on

April 28 from 12-1 PM in the same room, during which residents will present

the results of their research projects. Please RSVP to Nancy Ramirez by April 24

if you plan to attend the April 28 luncheon (nancyramirez@health.usf.edu).

Please make every effort to attend these events and support our trainees and

their mentors!!

KUDOS

Jeannette Fleischer, ARNP, was recognized by Metropolitan Ministries this month as Volunteer of the Day. She received a t-shirt, balloons, a certificate and thank you cards from staff and patients. Congratulations, Jeannette, and thank you for your dedication!

Dr. Lynn Ringenberg has been a mentor to Cindy Nguyen for her Capstone Project. Cindy has matched for an internal medicine residency, and her poster is being displayed at the USF Health Office of Research, Innovation & Scholarly Endeavors (RISE).

Brittany Leigh, senior PhD student in the laboratory of Dr. Larry Dishaw, was invited to be a keynote speaker at the 22nd Evergreen International Phage Meeting to be held in August. This is a great honor, as graduate students are seldom invited to be keynote speakers at international congresses.

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Letter continued from page 1 unfounded fear.

We need to promote critical thinking in our society and among ourselves. It takes effort to take the time to explain not just what but why and be credible and trustworthy to our patients and families. Our evidence-based discussions on Friday morning are wonderful opportunities to review the hierarchy of evidence, discuss the nuances of statistical analysis and help students and residents analyze the myriad of data they face each day. We all need to understand the what and why and not just say “that’s the way we do it here”.

Tomorrow is the March for Science all over the country – there will be a march in St. Pete and Clearwater. In addition to our individual practices we need to fight for continued support of research and education in all areas of science. Our lives and our world depend on it…. To support our trainees’ efforts at moving science forward I also recommend that everyone make an effort to attend the Fellows Forum and Resident Forum being held next week.

To end, as Dr. Dzau did, with a quote from Hippocrates:

“There are in fact two things, science

and opinion; the former begets

knowledge, the latter ignorance.”

Patricia J. Emmanuel, M.D. Chair, Department of Pediatrics

CLINICAL TEAM MEMBERS OF THE MONTH Katrina Cavalieri is March’s Clinical Team Member of the Month! Katrina is an LPN at the USF CMS clinic. Nominators noted that she always goes above and beyond to provide ex-cellent patient care, she has extensive knowledge of pediat-rics and strong clinical skills, is versatile and able to cover all areas for multiple pediatric subspecialties, and is an exempla-ry team member. Her extraordinary work ethic makes her a respected and appreciated member of her team. She is very pleasant and pro-fessional and provides outstanding customer service to our patients and fami-lies, who frequently comment on her kindness, patience, skill and gentle ap-proach with their children during procedures. Congratulations, Katrina!

Tatiana Williams is April’s Clinical Team Member of the Month. Tatiana is a CMA at the 17 Davis Clinic. Nominators noted her great interactions with residents, patients and families, and that she consistently prepares in advance to effectively communicate with the team regarding each day’s plan. She is prompt, orga-nized, thorough and efficient, anticipates what is needed for pa-tients and what the provider will order. She goes above and be-yond to provide patients with excellent care, and is very friendly

and professional. Her performance, skill, compassion and her friendly smile make her a shining example of excellence. Congratulations, Tatiana!

PUBLICATIONS

Walsh A, Wesley K, Tan S, Lynn C, O’Leary K, Wang Y, Nguyen D, Chenneville T, Rodriguez C. Screening for depression among youth with HIV in integrated care settings. AIDS Care, 29(4), 1-7, 2017.

Leigh B, Liberti A, Dishaw LJ. Generation of germ-free Ciona intestinalis for studies of gut-microbe interactions. Frontiers in Microbiology, Dec 27;7:2092, 2016.

Leigh B, Karrer C, Cannon JP, Breitbart M, Dishaw LJ. Isolation and characterization of a Shewanella phage-host system from the gut of the tunicate, Ciona intestinalis. Viruses, Mar 22;9(3), 2017.

RESIDENCY CORNER

Drs. Christa Root and Kimberly Law volunteered at the Johns Hopkins All Children's Teddy Bear Clinic where over 100 kindergarteners learned about the hospital, dressed as doctors, and learned about taking vitals, giving medications, starting IVs, fire safety, ambulances, and nutrition with their very own new teddy bear!

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MATCH DAY

We are very pleased to announce that we filled our spots for this year’s match with 4 Med-Peds and 12 Peds first year positions:

Pediatrics Residency Class of 2020

Shaara Argo, USF

Ashmit Bhatt, Lake Erie College of Osteopathic Medicine

Mandy Brasher, University of Kentucky

Melanie Burnett, Philadelphia College of Osteopathic Medicine

Michaela Churilla, USF

Lisa Dinh, USF

Sara Garcia, USF

Matthew Gates, Florida International University

Mary Beth Melvin, University of Florida

Ryan Reynolds, Louisiana State University

Summer Rye-Buckingham, University of Central Florida

Monica Shah, NOVA Southeastern University College of Osteopathic Medicine

Med-Peds Residency Class of 2021

Alex Glaser, USF

Ali Grana, USF

Holly O’Brien, USF

Charlie Overturf, West Virginia School of Osteopathic Medicine

MATCH DAY

GRANTS & CONTRACTS

Investigator: Diane Straub, MD Title: Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Coordinating Center. Sponsor: Indiana University

Investigator: Jolan Walter, MD Title: Assessing the Role of T and B Cells in Re-fractory Cytopenias in Immunocompromised Children. Sponsor: All Children’s Hospital

Investigator: Adam Lewin, PhD Title: Transdiagnostic Treatment for Youth with Complex Cormobidity and Tourette Disorder. Sponsor: Tourette’s Syn-drome Association

GRAND ROUNDS April 27 An Ounce of (HIV) Prevention….. Patricia Flynn, MD 2017 Lewis A. Barness Lecture

May 4 Polycystic Ovary Syndrome in Adolescents Florence Desrosiers, MD

May 11 Riboflavin Transporter Deficiency Amarilis Sanchez-Valle, MD

May 18 Pediatric Emergency Medicine Judith Lucas, MD

May 25 Resident Quality Improvement and Research Presentations USF Pediatrics Residents

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PAS Dr. Emmanuel and other Chairs of Pediatrics from Florida are hosting a Florida Pediatrics Reception dur-ing the Pediatric Academic Socie-ties meeting next month. The re-ception will be held at the San Francisco Marriott Marquis from 7:30 to 9:30 PM.

HAPPENINGS A fun time was had at Dr.’s Day, held at HealthPark on March 22

The USF Pediatrics/Med-Peds 2017 Softball/Kickball Game was held on March 25 – a great time was had by all! Thanks to Kelly Paulina for organizing and Dr. Lynn Ringenberg for the photography!

The Ybor Youth Clinic is partnering with Kendra Scott's Hyde Park store on May 4th from 5 to 8 PM for a fun night of shopping for a good cause. The store will be hosting all friends of YYC with refreshments and the opportunity to pur-chase jewelry, with 20% of the proceeds donated back to the YYC. The store is located in Hyde Park Village.

SAVE THE DATE

April 27 Lewis A. Barness Lecture and Fellows Forum

April 28 Residents Forum

May 4

Ybor Youth Clinic KENDRA GIVES BACK Event

May 6-9 Pediatric Academic Societies Meeting

FACULTY IN THE NEWS

Dr. Terri Ashmeade was featured on the USF Health home page this past month. The piece described her research on the use of facial expression recognition to enable caregivers to detect when infants are experiencing pain. She is working with facial expression recognition experts from the USF College of Engineering. Their work is sponsored by a Women’s Health Collaborative Seed Grant, and the team has applied for further funding from NIH.

Dr. Diane Straub was featured in a Feb 27 10 NEWS piece about websites that can encourage eating disorders, while Dr. Denise Edwards was featured in Feb. 24 a piece about the use of food stamps to buy sugary foods.

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PRESENTATIONS

Dr. Larry Dishaw delivered 3 invited departmental seminars: Host Factors, Biofilms, and Viruses: Assembly and Maintenance of Gut Barriers. Emerging Pathogens Institute, University of Florida, Gainesville, Feb 15.

Protochordate Insight into the Developmental Maturation of a Gut Ecosystem. The Whitney Laboratory, University of Florida, St. Augustine, Feb 17. Transkingdom Interactions Define the Assembly and Maintenance of Gut Barriers. School of Life Sciences, Arizona State University, April 3.

Dr. Jolan Walter is proud to feature USF’s participation in the American Academy of Allergy, Asthma, and Immunology (AAAAI) meeting held March 3-6 in Atlanta, and the Clinical Immunology Society (CIS) meeting held March 23-27 in Seattle. Faculty and trainees from the Division of Allergy/Immunology participated in venues ranging from posters, moderating sessions, and presentations for the CIS Summer School. See page 6 for more details on Clinical Immunology Society and AAAI.

RESEARCH DAY

USF Peds had an outstanding showing at this year’s Research Day, which included 3 awards! Former Peds Chairman Dr. Robert Nelson also made a surprise appearance – he was co-author on a poster with Ana Santos. For a complete list of posters and awards, please see page 7.

CLINICAL IMMUNOLOGY SOCIETY Drs. Jolan Walter and Jennifer Leiding moderated guided poster sessions, while Dr. David Lindsay presented Severe Combined Immunodeficiency (SCID) Caused by Thymic Aplasia Due to Familial Mutation in TBX1 at a guided poster session. CIS Summer School: Malik A. Refractory Autoimmune Cytopenia Coincides with Varicella Infection in a Child with RAG Deficiency Bulkhi AA. Antineutrophilic cytoplasmic antibodies (ANCA)–associated Vasculitis in a Common Variable Immunodeficiency Patient Castro-Wagner JB. Use of Vedolizumab in Treatment of Chronic Granulomatous Disease (CGD)–associated Colitis Patel B. Diagnosis of Kabuki Syndrome in a Patient with Immunodeficiency Lindsay DS. Severe Combined Immunodeficiency (SCID) Caused by Thymic Aplasia due to Familial Mutation in TBX1 Posters Castro-Wagner JB, Wilsey M, Petrovic A, Zerbe C, Leiding JW. Hypercoagulable State in Chronic Granulomatous Disease (CGD) Patel B, Leiding J. Evolution of immunodeficiency in a patient with Kabuki Syndrome Duff C, Leiding J. Initiation of 20% Subcutaneous Immunoglobulin Therapy in Patients with Primary Immunodeficiency Naïve to IG Therapy Gillespie M, Kubiak C, Patel B, Ballow M, Leiding J. Variable Presentations of Chromosomal Instability Syndromes

Sriaroon P, Chang Y, Ujhazi B, Csomos K, Joshi H, Zhou Q, Close D, Armanios M, Walter JE, Kumanovics A. Thrombocytopenia as Initial Presentation of IKAROS Deficiency Associated with a Novel IKZF1 Mutation

Csomos K, Ujhazi B, Stoltz K, Ijspeert H, Mei Yan, Quan-Zhen Li, Csizmadia E, Butte MJ, Coppola D, van der Burg M, Tarakanova V, Walter JE. MHV68 Infection in a Novel rag2F62L/F62L Mouse Model Based on a Patient with CID-G/AI Phenotype

Westermann E, Grossi A, Fioredda F, Giardino S, Cappelli E, Terranova P, Palmisani E, Farmer J, Foldvari Zs, Yamazaki Y, Faraci M, Lanino E, Notarangelo LD, Dufour C, Ceccherini I, Walter JE, Miano M. Partial RAG Deficiency in a Child with Autoimmune Cytopenia and Features of Autoimmune Lymphoproliferative Syndrome (ALPS)

Goda V, Malik A, Kalmar T, Maroti Z, Patel B, Ujhazi B, Csomos K, Krivan G, Walter JE. Refractory Autoimmune Cytopenia Coincides with Varicella Infection in a Child with RAG Deficiency

Meyer AK, Patel B, Amre D, Trotter J, Sriaroon P, Oshrine B, Hale G, Shaw PH, Grans N, Mayer J, Metts J, Ayala I, Petrovic A, Leiding J, Walter JE. Clinical Features and Treatment Responses of Autoimmune Cytopenias with Primary Immunodeficiency at a Tertiary Pediatric Care Facility

Ong MS, Walter JE, Grand RJ, Mandl KD. Identifying Predictors of Primary Immunodeficiency (PID) in Inflammatory Bowel Disease (IBD) Bartmettler S, Ong M, Farmer J, Choi H, Walter JE. Retrospective Analysis of the Importance of Immunologic Evaluation in Patients Receiving

Rituximab and Clinical Implications Farmer J, Ong MS, Yonker L, Sullivan K, Cunningham-Rundles C, Walter JE. Broadening our Understanding of the Noninfectious Disease

Complications of CVID within the United States Barmettler S, Farmer J, Abraham RS, Smith MJ, Hale J, Comeau A, Walter JE. Functional Diagnosis of Ataxia Telangiectasia in a Female Infant

Identified via Newborn Screening for Severe Combined Immunodeficiency

AMERICAN ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY

Posters Sher M, Mair E, Messina J, Carothers J, Mahmoud R, Djupesland P. EXHANCE-3: A Phase 3, Three-Month Study of Safety and Efficacy of

Fluticasone Propionate Exhalation Delivery System (FLU-EDS) in Patients with Chronic Rhinosinusitis with (CRSwNP) and without Nasal Polyps

Castro-Wagner JB, Lin CH, Tabatabaian F, Tang, Sriaroon P. Omalizumab Treatment in Patients with Cystic Fibrosis (CF) and AllergiBronchopulmonary Aspergillosis (ABPA): a Case Series

Alberdi T, Castro-Wagner JB, Patel B, Joychan S, Lindsey D, Laham FR, Csomos K, Ujhaz B, Duff CM, Trotter J, Bleesing JJ, Kumanovics A, Chang Y, Hale JH, Sriaroon P, Hale G, Oshrine BR, Notarangelo L, Abraham RS, Comeau AM, Petrovic A, Leiding JW, Walter JE. An Atypical Severe Combined Immunodeficiency (SCID) Case Diagnosis Complicated by Alternative Care in the Era of Newborn Screening (NBS) for SCID

Joychan S, Toon JY, Grana N, Leiding JW. A Child with Acute Lymphoblastic Leukemia Presenting with Severe Hypereosinophilia Patel B, Tabatabaian F, Ledford DK, Leiding JW. Idiopathic CD4 T Lymphocytopenia and the Association of Autoimmunity Involving the

Nervous System Platforms Duff CM. Education to Promote Independence with SCIG; Leiding JW. Congenital Phagocytic Defects; Sher MR. Co-Discussion leader with AB Goldsobel. New Concepts in Patients with Chronic Cough; Walter JE. Co-Discussion leader with Roshini Abraham. Anti-Cytokine Autoantibodies in Human Disease; Duff CM. Co-facilitator with WR Blouin. Anaphylaxis: Cases in Simulation; Walter JE. Primary Immune Deficiency

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RESEARCH DAY

Patel B, Ujhazi B, Csomos K, Walter J. An Emerging Phenotype of Partial RAG I/II Deficiency Among Young Children with Autoimmunity and Viral Infections. Best MCOM Resident Poster Presentation: Case Studies

Pedapudi M, Emmanuel E. The Integration of Tampa General Hospital: A Physician’s Role in Creating Healthcare Equality. Best MCOM Medical Student Presentations: Med III Student Poster Presentation, Interdisciplinary Case Studies

Cobb H, Abrahan D, Murphy M, Straub D. Improving the Quality of a Quality Improvement and Patient Safety Curriculum in a Pediatric Residency Program. MCOM Outstanding Resident Trainee

Dutra S, Groer M, Gilbert J, Yee A, Dishaw, Armstrong K, Ji J, Miller E, D’Agata A, Duffy A. Preterm Infant Microbiome Profile

Liberti A, Leigh B, Graham Z, Creasy A, Cannon JP, Litman GW, Dishaw LJ. Bacterial-specific Lytic Phage Can Re-shape Colonization Dynamics in a Marine Invertebrate Model

Graham Z, Leigh B, Dishaw LJ. Prophages within Bacteria Isolated from the Gut of the Model System, Ciona intestinalis

Santos Ana, Zeager M, Nelson R, Mills G. PhotoVoice Project: Health Initiative in Underserved Communities in the United States Subject to the Same Environmental Hazards as Developing Countries in the 21st Century.

Blanco M, Law K, Takagishi J, Burton T. Brush, Book Bed: Goal of Improving Dental Hygiene, Literacy and Sleep

Cristoforo T. Evaluating the Necessity of Antibiotics in the Treatment of Acute Epididymitis in Pediatric Patients: A Literature Review of Retrospective Studies and Data Analysis

Cristoforo T, Soa P, Steele J, Couluris M, Takagishi J, Burton T. Increasing Efficacy of Asthma Education: Using Family Input to Create Patient-Centered Education

Walsh A, Lynn, C, Cambric M, Chenneville T, Rodriguez C. Depressive Symptoms Related to Biological Markers of Immune Functioning among Young People with HIV

Lynn C, Walsh A, Cambric M, Cario A, Chenneville T, Rodriguez C. HIV Health Literacy in a Pediatric Infectious Disease Clinic: A Preliminary Analysis

Joychan S, Yoon J, Grana N, Leiding JW. A Child with Acute Lymphoblastic Leukemia Presenting with Severe Hypereosinophilia

Csomos K, Ujhazi B, Stoltz K, Ijspeert H, Mei Yan, Quan-Zhen Li, Csizmadia E, Butte MJ, Coppola D, van der Burg M, Tarakanova V, Walter JE. MHV68 Infection in a Novel rag2 F62L/F62L Mouse Model Based on a Patient with CID-G/AI Phenotype

Castro-Wagner J, Trotter J, Eason D, Mueller G, Goldenberg N, Leiding JW. Hypercoagulable State in Chronic Granulomatous Disease (CGD)

Lindsay D, Duff C, Oshrine B, Leiding JW. Severe Combined Immunodeficiency (SCID) Caused by Thymic Aplasia Due to a Mutation in TBX

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