Tellico Village Computer Users Club
Tellico Village Computer Users Club
TVCUCFellowship Hall Internet
The Network Name has changed from TVCUC-Guest to:
SSID: Fellowship_Hall-guest_2GHzPassword: guest
This is a great time to renew your 2017 TVCUC membership.
See the Membership Team at the door.
TVCUC General Meeting
February 7, 2017
Tellico Village Computer Users Club
TVCUC
Tellico Village Computer Users Club
Tellico Village Computer Users Club
TVCUCWelcome to the February TVCUC meeting
A big WELCOME to all our guests and new members since the last meeting.
Please turn off the sound on your cell phones!
Does everyone have your door prize ticket?
Tellico Village Computer Users Club
Tellico Village Computer Users Club
TVCUCAgenda
Welcome and Opening Comments
Vote to Approve Changes to Bylaws
Committee Reports
Tonight’s Program:
o Provision Healthcare – Tom Welch, President
o ProNova Solutions – Joe Matteo, Co-Founder & President
New Member Welcome
Door Prizes
Tellico Village Computer Users Club
Tellico Village Computer Users Club
TVCUCTVCUC Bylaws Vote
The TVCUC Bylaws have been updated to reflect recent changes to Articles of Incorporation.
Clarified a number of items, including the following:
a. Membership privileges
b. The criteria for and officer status of the Past President position
c. The types and duties of committees
Added a new Article regarding Club policies
Made numerous editorial and clerical changes
Approved?
Tellico Village Computer Users Club
Tellico Village Computer Users Club
TVCUCMembership Update
We in the middle of Membership renewal for 2017. The renewal form is on ourwebsite TVCUC.org under Member Services tab. Dues are $15 per household andcover membership through Dec. 2017.
Renewal options:1. Complete the form on your computer then print and submit it with your
check at a monthly meeting2. Print the form, complete and submit it with your check at the meeting3. Print the form, complete and submit it with your check by mailing it to the
TVCUC address found at the bottom of the Membership form.
Your dues make you eligible for all the TVCUC benefits: First Level Support,Educational Classes, Computer Related Tours, Monthly Meetings, Support for TAP,and Special Interest Groups
Tellico Village Computer Users Club
Tellico Village Computer Users Club
TVCUC2017 Programs
Month Program
January No meeting
February Proton TherapyProNova Manufacturing
March Smart Phone/Tablet 102
April TBD
May Cyber Terrorism (tentative)
June Annual Picnic
September TBD
October Cutting the Cord (ii) (tentative
November Annual Meeting
December Cloud Computing (tentative)
Tellico Village Computer Users Club
Tellico Village Computer Users Club
TVCUC2017 Tour Schedule Oak Ridge National Labso Feb 28: High Flux Reactoro March 28: Supercomputero April 25 Neutron Spallationo May 3: National Transportation Research Center
Manufacturing Demonstration Facility
MasterCraft Boats o April 18 (Limit 12)
TVA River Forecast Center (TBD)
Provision Proton Center (TBD)
ProNova Factory Tour (TBD)
Volkswagen (Hopefully!!)
Other new venues being investigated.
You may register for these tours on our website.
www.TVCUC.org/Tours
Tellico Village Computer Users Club
Tellico Village Computer Users Club
TVCUC 700+ Member Assists in 2016
101 Member Assists in January 2017
Started monthly “Meet with First Level Support” with great success.
─ 4th Tuesday @3:15, Chota Rec Center D
Top Issues─ Ransomware, Fake Virus & what to do
o DO NOT give anyone control of your computer (and your bank account) that you don’t know.
─ Real virus infections and not using the security programs we recommend for Windows 10.
o Defender, MalwareBytes, SuperAntiSpyware, Ccleaner
─ Lost or forgotten passwords: o We can't fix it if you don't know your passwords
─ Making Windows 10 user friendly (not the same, just friendly)
─ Slow computers and boot-up problems
─ Router and connectivity Issueso I just lost my internet connectiono Printer problems
CALL US BEFORE YOU GET SO FRUSTRATED THAT YOU WANT TO DO THIS!
To get First Level Support, go to our website www.tvcuc.org
FLS available for Windows, Apple OS, Smart phones/Tablets -- IoS & Android
First Level Support
Tellico Village Computer Users Club
Tellico Village Computer Users Club
TVCUCT.A.P. Systems Given to Families YEAR SYSTEMS CHILDREN
2007 43 98
2008 144 247
2009 184 297
2010 431 620
2011 599 979
2012 565 1032
2013 704 1340
2014 683 879
2015 746 1065
2016 611 841
2017 114 67
TOTALS 4,820 7,465
11
Company Overview
February 2017
12
The PET Benefit
ProtonGuys
Provision CARES Proton Therapy Center
15
Proton Therapy Precisely Targets Tumors
More Precise – Fewer Side Effects
Proton Therapy is an advanced form of radiation therapy for cancer. It precisely targets
tumors, reducing the amount of radiation exposure a patient’s body receives during
treatment. As a result, there is less damage to healthy tissue and patients experience
fewer short-term and long-term side effects.
16
Proton Therapy Reduces Risk of Secondary Cancers
Information Courtesy of MD Anderson Cancer Center
Proton Therapy for Breast Cancer
Proton Treatment Plan for Post Mastectomy Breast Cancer Patient on Left; IMRT Plan for same patient on right
A Comparison of Radiation Dose for a Patient with Breast Cancer
STRUCTURE MEASUREMENT IMRT PROTONS INCREASE IN RADIATION DOSE
Left Lung Volume Receiving 5 Gy 44.75% 13.78% 3.25x the radiation with IMRT
Volume Receiving 20 Gy 31.01% 3.19% 9.72x the radiation with IMRT
Volume Receiving 30 Gy 24.69% 0.71% 34.77x the radiation with IMRT
Mean Dose to Left Lung 14.41 Gy 2.3 Gy 6.27x the radiation with IMRT
Heart Volume Receiving 2 Gy 46.73% 0%
Volume Receiving 5 Gy 18.18% 0%
Volume Receiving 10 Gy 13.38% 0%
Volume Receiving 20 Gy 8.22% 0%
Mean Dose to Heart 5.17 Gy 0.01 Gy 517x the radiation with IMRT
17
Excess Radiation
with X-Rays
HeartLungs
Breast
Heart Lungs
Breast
Proton IMRT
18
New Treatment Indications Using PBS:
(80% of All Radiation Treatments)Larger Non-contiguous Targets
• Lung
• Liver
• Breast
• Esophagus
• Pelvic tumors
• Large sarcomas
• High risk prostate
• Mediastinal tumors
• Pancreatic tumors
• Bone
• Genital organs
• Rectal
• Other cancers
• Re-irradiation of recurrent tumors
Pencil Beam (PBS) Proton Therapy is better in 80% of cancers treated by X-rays.
Pre-PBS Indications:
(20% of Radiation Treatments)Smaller Contiguous Targets
• Base of skull tumors
• Eye (uveal) melanomas
• Brain tumors
• Pediatric tumors
• Spinal / Para spinal tumors
• Prostate cancers
• Lung
Proton Therapy Can Treatment Most Solid Tumors
Patient Home Locations to PCPTC for Treatment
Alaska
Hawaii
Arizona
Colorado
Texas Louisiana
Arkansas
Mississippi
Missouri
Tennessee
IndianaOhio
Kentucky
AlabamaGeorgia
South Carolina
North Carolina
Virginia
WestVirginia
Illinois
Wisconsin
Michigan New York
Maine
MarylandWashington D.C.
Florida
Patients have come from 27 states and 6 countries for treatment. International patients have come from China, United Kingdom, Brazil, Russia, The Netherlands, and
Mexico.
Proton Capacity Continues to Expand in US
Provision Healthcare Division Synergy
Provision
Solutions
Provision
Medical
Group
ProNova
Solutions
Provision
Proton
Centers
Provision
Healthcare,
LLC
Provision
CARES
Cancer
Center
2323
One Call. One Focus. CANCER.
Provision CARES Cancer Center Campus
24
Campus
A world-class comprehensive cancer center
committed to the development of new, innovative,
comprehensive healthcare product and service
solutions that will make major improvements in
patient care, outcomes and value.
Services Offered:
• Proton Therapy• Radiation Therapy• Chemotherapy• Comprehensive Breast Care• Comprehensive Prostate Care• Diagnostic Imaging• Health & Wellness • Physical Therapy• Primary Care
Physicians on Campus:• Medical Oncologists
• Radiation Oncologists
• Breast Radiologists and Surgeons
• Radiologists
• Endocrinologists
• Gastroenterologists
• Primary Care
• Orthopedics
25
Provision Radiation Therapy
Alternative Offering for Patients with
Insurance Coverage Issues
Delivery Offering: 3D Conformal Therapy (3-D)
Intensity-Modulated Radiation Therapy (IMRT)
Stereotactic Body Radiotherapy (SBRT)
Volumetric-Modulated Arc Therapy (VMAT)
SymmetryTM Respiratory Motion Management
25
Tennessee Cancer Specialists
6 Medical Oncologists
5 Nurse Practitioners
36 Infusion Stations
Pharmacy
Lab Services
Clinical Research
26
Knoxville Comprehensive Breast Center
4 Breast Radiologists
1 Breast Surgeon
2 Breast MRI’s
6 Digital Mammogram
10 Ultrasound Units
Mobile Mammography
One of the Largest
Breast Health Centers in
the Southeastern US
27
Mobile Mammography
28
Diagnostic Imaging Center
3 Tesla MRI
1.5 Tesla MRI
Nuclear Medicine Gamma Camera
PET/CT
64 Slice CT Scanner
Ultrasound
X-Ray
Provision Imaging, LLC
28
Gastrointestinal Associates, P.C.
17 Gastroenterologist
8 Advanced Practitioners
Largest GI group in the region
Farragut ENT
4 Physicians
1 Nurse Practitioner
Head & Neck Cancer Specialists
96 years of combined MD experience
1st in East TN to perform • Endoscopy sinus surgery• In office balloon sinuplasty• Utilize naviation
1 of 12 Sinus Centers of Excellence in the US
Our Research Partners.
Clinical Trials Management and Therapeutic Drug Evaluation
• 29 Active Clinical Trials
• Range from Phase II – Phase IV trials
• Lengthy history of managing ground-breaking clinical trials
• Herceptin
• Avastin
• Imbruvica
• Immunotherapies
Provision Multi-Disciplinary Tumor Conferences
Specialists from every cancer care provider in Knoxville gather at
Provision to collaborate and review current patient cases with the goal
of determining the best care plan for each patient
• 5 conferences per month
• Up to 50 patient cases reviewed
each month
• Patients are presented from
multiple cancer centers and are
often referred across institutions in
the best interest of the patient
• Collaboration continues to grow as
more doctors express interest in
joining Provision tumor
conferences
Care Coordination at Provision Cancer Center
Provision prioritizes the patient experience
• Dedicated Patient Experience Team
• Hospitality services for out of town patients
• Patient satisfaction is core objective for all
teams – monthly tracking
• 700 former patients have become
Ambassadors for Provision and proton therapy
Provision provides personal guides
One call to a Provision Care Coordinator
equips patients with a clear path forward
for treatment
Our goal is to manage the details so
patients can focus on what’s most
important to them
Provision CARES Foundation
• A not-for-profit 501(c)(3) public cancer-care charity that
provides cancer awareness, education, wellness,
research and assistance for patients, their families, and
the public in East Tennessee.
• Provided services to more than 1,400 people in 2016
• Helped cancer patients receiving treatment at 9 different
healthcare providers
• Served 10,986 meals to cancer patients & their families
from 40 different East Tennessee cities in 2016
Thank you
Joe Matteo, President ProNova Solutions
ProNova: A Closer Look
Unique Complementary Capability in Proton Therapy and
Cancer Care
• Comprehensive Cancer
Center
• Proton Center
• Radiation Treatment
• Comprehensive Wellness
• Training Center
• Total Solutions
• Co-ownership
• Funding
• Strategic Planning
• Management Services
• Real Estate
• Partnership Development
• Cutting Edge Technology
• Reduced Costs
• Reduced Complexity
• Reduced Time-to-Market
• Efficient Workflow
• Commercial Production
Compact ProNova SC360 System
Up to one-half the size
Up to one-tenth the weight
Up to one-half the construction costs
Conventional
360° Gantry
ProNova Mission
Serve Patients by Improving Access to Proton Therapy
To deliver a lower-cost, smaller, lighter, more energy efficient solution for
Proton Therapy without sacrificing performance and improving upon
existing capabilities, making proton more affordable and more accessible
to the cancer community
Gantry Comparisons
360 Gantry Partial Gantry
• Superconducting magnets have multiple benefits
- Dramatically smaller size, weight, and power
- 2.5X higher magnetic field, 0.4X bend radius
• ProNova leverages superconducting magnet technology
- Ample room for full ring imaging at iso-center
- Simplified shipping and installation reducing cost and time to market
System Overview
PET at Isocenter
ProNova Unit 1 Install & Provision Center for Proton Therapy
ProNova Development Vaults Provision Clinical Vaults
38% - 62%
SC360 Treatment Room
Open square room provides improved patient access
Projection screens provide easy review of therapy
information
Open room provides clear access for lasers, projectors, Optical imaging, & intercom
43
Gantry with Partial Covers during TUV testing
Superconducting Achromat
• Fully assembled 60-degree achromat achieves full field!!!
- #1 technical risk to ProNova largely mitigated
- Achromat ready for install on TR4 gantry in early 2015
- 150-degree achromat ready June 2015
Superconducting Magnet use in Proton Therapy
60° Superconducting Magnet
150° Superconducting Magnet
Integrated CBCT - Precision patient positioning for particle therapy
ImagingRing has not been cleared by the US FDA for commercial distribution
in the US and is not available for commercial distribution at this time.
• Fast flat panel: 30 Hz framerate
• Single source dual energy X-ray: 40 – 120 kV
• Large clearance: 78 cm ring, 102 cm tube
• Large FOV: >63 cm diameter, >32 cm long
• Fast rotations: up to 5 rpm, non-isocentric acquisitions
• Collimator: 4 jaws, primary modulation, filter wheel
• Light field
• Planar / fluroscopic / volumetric kV imaging
• 2D/3D and 3D/3D functionality
Large FOV – Non-Isocentric Imaging
ProNova Accelerator Evolution
Ironless variable energy
SC synchrocyclotron
(no degrader necessary)
MIT – ProNova Collaboration
F2800
Resistive Cyclotron SC Cyclotron Ironless SC Synchroyclotron
Size F4.4m F2.8m F2.8m
Weight 220 ton 50 ton 5 ton
Power 340 kW 190 kW 50 kW
Extracted Beam 230 MeV 230 MeV 70-230 MeV
Deep Tissue Beam Current 300 nA 600 nA 100nA
Shallow Tissue Beam Current 6 nA 12 nA 100nA
ProNova DevelopmentSumitomo - ProNova Collaboration
ProNova Compact SC360 One-Room Solution
“The Best of Both Worlds”
•Truly Compact 360°- 45% smaller footprint
- Lower build out cost
- More efficient workflow
•No Compromises- Advanced Imaging
a)CBCT at any bed position with no gantry motion
b)PET for range verification
- Advanced workflow
PRONOVAVARIAN
8,607 ft2
17,700 ft2
ProNova / Typical 2G + 1F Comparison
• 51% Smaller footprint
• $10,484,589 Saved in vault construction
- Vault construction cost estimated based on cubic yards of concrete, mechanical, and foundation costs.
a) ProNova -$1,315.09 per square foot
b) Varian - $1,231.84 per square foot
10-year Total Cost of Ownership
• Total Cost of Ownership Reduced by $25 Million
ProNova Solutions – Maryville, Tennessee
• 55,000 ft2 R&D and Manufacturing facility
• LEED certified energy efficient facility
• Opened January 2015
• Phase I capacity of 10 two-room systems per year
• Phase III capacity of 50 two-room systems per year
SC360 1st Article Build
Medical Device Clearance 2016
• FDA CLEARANCE!!!
- 4 years from first employee to final data (March 2012 – April 2016)
- 2 gantry iterations, 2 buildings, full integration of both
- State-of-the-art superconducting achromat developed and
commercialized
- ISO13485 cert, TUV, usability, scanned volume, 3D imaging, PBS
CLEARED12/8/2016
Leading Innovation
Compact 360 degree open access to isocenter
Integrated couch based ImagingCBCT - Dual energy, Fan beam (adaptive), multi-slice, spiral
In-beam PET (2018)
Fast volumetric deliveryMultimode fast scan magnet
Raster scanning (2018)
High beam current
Room and layer switching
PRONOVA is the treatment room of the future
Exclusives
Workflow centric toolset
Tellico Village Computer Users Club
Tellico Village Computer Users Club
TVCUCThanks for coming! Welcome new members tonight Jim Autry
Door Prize Drawing Kathy Economy