Ferrous BisglycinateFerrous Bisglycinate
The haemoglobin enhancer with a difference
o
o
o
o
NH 2
H 2 N
Fe
0
9.5
15.4
33.3
0
5
10
15
20
25
30
35
Fe Bis (30 mg) Fe Bis (60 mg) Fe Bis (120 mg) FeSO4 (120 mg)
GI side effect(% incidence)
FERROUS BISGLYCINATE
1.Am J Clin Nutrition 1998;67:664-82.Arch Latinoam Nutr. 2001 Mar;51(1 Suppl 1):7-12.3.Nutrition 2001,17,381-844.IMG- 2006.5.http://www.efsa.europa.eu/EFSA/efsa_locale-1178620753812_1178620765635.htm
5GI tolerability
Advantages of the chelated ferrous bisglycinate
l
l
l
l
l
l
Absorbed intact
Easily absorbed into the mucosal tissue
Highest bioabsorption
High bioavailability even in presence of phytates, tannates, oxalates etc.
Less likely to cause intestinal side effects such as nausea, constipation and bloating
Does not interact with multivitamins
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The Mark of Innovative Chemistry
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The Mark of Innovative Chemistry
FERROUS BISGLYCINATE
Iron supplement Elemental iron
Bioavailale iron
AmountAbsorbed (mg)
Ferrous sulfate
33%
26.7%
9
Ferrous ascorbate
12%
40%
4.8
Ferrous fumarate
32%
28%
8.9
Ferrous bisglycinate 19 - 21% 90.9% 17 - 19
4Efficacy in pregnant women
Baseline 21 days
8.2
Hb
- g
m/d
l
42 Days
8.2
8.9
8.4
8.6
8.8
9.0
9.2
9.4
9.6
9.8
9.6
Significant changesin Hb levels after
6 weeks
Significant changesin Hb levels after
28 days
Ferrous sulfate Ferrous bisglycinate
1.5
Hb
-g
m/d
l
Infants 6 - 336 months
1.6
1.7
1.8
1.9
2.0
2.1
2.22.3
2.4
2.5
1.8
2.5
Bioabsorption90.9 % - Fe bisgly
27.% - FeSO4
FERROUS BISGLYCINATEFERROUS BISGLYCINATE
Iron deficiency anaemia
Treatment options
Ferrous salts
Ferric salts
Iron (Fe) deficiency is probably the most common single nutrient deficiency throughout the world. It is
estimated that more than 500 million people throughout the world suffer from severe iron deficiency
anaemia.
Iron deficiency anemia is better controlled along with diet rich in iron source and supplementation of
external source of Iron formulations. Various iron salts are available for supplementation in the
treatment of anaemia. They are:
All dietary iron has to be reduced to ferrous form to enter the mucosal cells. Hence bivalent iron salts
like ferrous sulfate, fumarate, gluconate, succinate, glutamate and lactate have been preferred over
ferric salt preparations.
These salts have uniform bioavailability. However, the bioavailability decreases markedly in the
presence of dietary inhibitors like phytates, oxalates, tannates etc., which are abundantly
available in foods.
Despite being efficacious and cheap with good bioavailability, ferrous salts have several
disadvantages particularly the high incidence of gastrointestinal side effects (~23 %). Ferrous
sulphate has a salty astringent taste which is not palatable for most children.
Ferric salts have traditionally not been preferred over ferrous salts as the ferric ion first requires
reduction to ferrous form in the intestinal lumen and usually this reducing capacity is not enough to
reduce doses of iron therapeutically administered. The bio-availability of iron from ferric salts is 3 to 4
times less than that of ferrous sulphate.
l
l
Bioavailability
Tolerability
H2
H2
H C2
C
C
CH2OO
O ON
N
Fe
Ferrous bisglycinate - The
haemoglobin enhancer with a
difference
Ferrous bisglycinate consists of one molecule of
ferrous iron bound to two molecules of glycine.
Ferrous bisglycinate has been successfully sold in
the United States as dietary supplement for over 25
years and has received GRAS (Generally
Recognized as Safe) approval from the US FDA. Many countries like the Canada, United Kingdom, the
Netherlands, Spain, Denmark, France, Italy, China and Japan have approved ferrous bisglycinate.
Ferrous bisglycinate enjoys the privilege of being a highly absorbable iron supplement exceeding
ferrous salts.
Following oral administration, ferrous bisglycinate is absorbed intact into the mucosal cells of the
intestine, and is subsequently hydrolysed into its iron and glycine components. The iron component of 1ferrous bisglycinate is metabolised like any other source of iron. The solubility of iron from ferrous
bisglycinate is not affected by changes in pH.
The bioavailability of the ferrous bisglycinate chelate and ferrous sulfate is 90.9% and 26.7%. Ferrous
bisglycinate has a relatively high bioavailability in the presence of dietary inhibitors like tannins and
oxalates.
Absorption
Bioavailability
3,4Clinical efficacy