FeverFever

Slide 12.23

Abnormally high body temperature

Hypothalmus heat regulation can be reset by pyrogens (secreted by white blood cells)

High temperatures inhibit the release of iron and zinc from liver and spleen needed by bacteria

Fever also increases the speed of tissue repair

Causes protein denaturation

Specific Defense: The Immune Specific Defense: The Immune System – Third Line of DefenseSystem – Third Line of Defense

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Antigen specific – recognizes and acts against particular foreign substances

Systemic – not restricted to the initial infection site

Has memory – recognizes and mounts a stronger attack on previously encountered pathogens

Types of ImmunityTypes of Immunity

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Humoral immunity (B cells)

Antibody-mediated immunity

Cells produce chemicals for defense

Incorporates protein complement system

Cellular immunity (T cells)

Cell-mediated immunity

Cells target virus infected cells

AntigensAntigens

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Any substance capable of exciting the immune system and provoking an immune response

Examples of common antigens Foreign proteins

Nucleic acids

Large carbohydrates

Some lipids

Pollen grains

Microorganisms

Self-AntigensSelf-Antigens

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Human cells have many surface proteins

Our immune cells do not attack our own proteins

Our cells in another person’s body can trigger an immune response because they are foreign

Restricts donors for transplants

AllergiesAllergies

Slide 12.28

Many small molecules (called haptens or incomplete antigens) are not antigenic, but link up with our own proteins

The immune system may recognize and respond to a protein-hapten combination

The immune response is harmful rather than protective because it attacks our own cells (cells that have formed protein-hapten complex)

Cells of the Immune SystemCells of the Immune System

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Lymphocytes Originate from hemocytoblasts in the red bone

marrow

B lymphocytes become immunocompetent in the bone marrow

T lymphocytes become immunocompetent in the thymus

Macrophages Arise from monocytes

Become widely distributed in lymphoid organs

Activation of LymphocytesActivation of Lymphocytes

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Figure 12.9

Humoral (Antibody-Mediated) Humoral (Antibody-Mediated) Immune ResponseImmune Response

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B lymphocytes with specific receptors bind to a specific antigen

The binding event activates the lymphocyte to undergo clonal selection

A large number of (B) clones are produced (primary humoral response)

Humoral (Antibody Mediated) Humoral (Antibody Mediated) Immune ResponseImmune Response

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Most B cells become plasma cells

Produce antibodies to destroy antigens

Activity lasts for four or five days

Some B cells become long-lived memory cells (secondary humoral response)

Humoral Immune ResponseHumoral Immune Response

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Figure 12.10

Secondary ResponseSecondary Response

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Memory cells are long-lived

A second exposure causes a rapid response

The secondary response is stronger and longer lasting

Figure 12.11

Active ImmunityActive Immunity

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Your B cells encounter antigens and produce antibodies

Active immunity can be naturally or artificially acquired

Figure 12.12

Passive ImmunityPassive Immunity

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Antibodies are obtained from someone else Conferred naturally from a mother to her

fetus

Conferred artificially from immune serum or gamma globulin

Immunological memory does not occur

Protection provided by “borrowed antibodies”

Monoclonal AntibodiesMonoclonal Antibodies

Slide 12.36

Antibodies prepared for clinical testing or diagnostic services

Produced from descendents of a single cell line (clones produced from 1 original cell)

Can be produced for any antigen

Examples of uses for monoclonal antibodies Diagnosis of pregnancy

Treatment after exposure to hepatitis and rabies

Antibodies (Immunoglobulins) (Igs)Antibodies (Immunoglobulins) (Igs)

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Soluble proteins secreted by B cells (plasma cells)

Carried in blood plasma

Capable of binding specifically to an antigen

Antibody StructureAntibody Structure

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Four amino acid chains linked by disulfide bonds

Two identical amino acid chains are linked to form a heavy chain

Figure 12.13b

Antibody StructureAntibody Structure

Slide 12.38b

The other two identical chains are light chains

Specific antigen-binding sites are present

Figure 12.13b

Antibody ClassesAntibody Classes

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Antibodies of each class have slightly different roles

Five major immunoglobulin classes IgM – can fix complement

IgA – found mainly in mucus

IgD – important in activation of B cell

IgG – can cross the placental barrier

IgE – involved in allergies

Antibody FunctionAntibody Function

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Antibodies inactivate antigens in a number of ways

Complement fixation

Neutralization

Agglutination

Precipitation

Antibody FunctionAntibody Function

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Figure 12.14

Cellular (Cell-Mediated) Immune Cellular (Cell-Mediated) Immune ResponseResponse

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Antigens must be presented by macrophages to an immunocompetent T cell (antigen presentation)

T cells must recognize nonself and self (double recognition)

After antigen binding, clones form as with B cells, but different classes of cells are produced

Cellular (Cell-Mediated) Immune Cellular (Cell-Mediated) Immune ResponseResponse

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Figure 12.15

T Cell ClonesT Cell Clones

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Cytotoxic T cells (used to be called Killer T cells)

Specialize in killing infected cells

Insert a toxic chemical (perforin)

Helper T cells

Recruit other cells to fight the invaders

Interact directly with B cells

T Cell ClonesT Cell Clones

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Suppressor T cells (think immune system negative feedback)

Release chemicals to suppress the activity of T and B cells

Stop the immune response to prevent uncontrolled activity

A few members of each clone are memory cells

Summary of the Immune ResponseSummary of the Immune Response

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Figure 12.16

Organ Transplants and RejectionOrgan Transplants and Rejection

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Major types of grafts

Autografts – tissue transplanted from one site to another on the same person

Isografts – tissue grafts from an identical person (identical twin)

Allografts – tissue taken from an unrelated person

Xenografts – tissue taken from a different animal species

Organ Transplants and RejectionOrgan Transplants and Rejection

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Autografts and isografts are ideal donors

Xenografts are rarely successful

Allografts are more successful with a closer tissue match

Disorders of Immunity: Allergies Disorders of Immunity: Allergies (Hypersensitivity)(Hypersensitivity)

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Abnormal, vigorous immune responses

Types of allergies

Immediate hypersensitivity

Triggered by release of histamine from IgE binding to mast cells

Reactions begin within seconds of contact with allergen

Anaphylactic shock – dangerous, systemic response

Disorders of Immunity: Allergies Disorders of Immunity: Allergies (Hypersensitivity)(Hypersensitivity)

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Types of allergies (continued)

Delayed hypersensitivity

Triggered by the release of lymphokines from activated helper T cells

Symptoms usually appear 1–3 days after contact with antigen

Allergy MechanismsAllergy Mechanisms

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Figure 12.17

Disorders of Immunity: Disorders of Immunity: ImmunodeficienciesImmunodeficiencies

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Production or function of immune cells or complement is abnormal

May be congenital or acquired

Includes AIDS – Acquired Immune Deficiency Syndrome

Disorders of Immunity: Autoimmune Disorders of Immunity: Autoimmune DiseasesDiseases

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The immune system does not distinguish between self and nonself

The body produces antibodies and sensitized T lymphocytes that attack its own tissues

Disorders of Immunity: Autoimmune Disorders of Immunity: Autoimmune DiseasesDiseases

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Examples of autoimmune diseases Multiple sclerosis – white matter of brain and spinal

cord are destroyed Myasthenia gravis – impairs communication between

nerves and skeletal muscles Juvenile diabetes (type I)– destroys pancreatic beta

cells that produce insulin Rheumatoid arthritis – destroys joints Systemic lupus erythematosus (SLE) – affects kidney,

heart, lung and skin Glomerulonephritis – impairment of renal function

Developmental Aspects of the Developmental Aspects of the Lymphatic System and Body DefensesLymphatic System and Body Defenses

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Except for thymus and spleen, the lymphoid organs are poorly developed before birth

A newborn has no functioning lymphocytes at birth; only passive immunity from the mother

If lymphatics are removed or lost, severe edema results, but vessels grow back in time