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p n ii ia ce uti c it, N utr ac e uti c at a n d C osm e c e uti c al"'-'i;;iioiogyi

iormulation and Applications

University Publication Centre (UPENA)

Uni*rri i f.knologi NARA o SHAH ALAV o 2010

O Universitl'Publication Centre (UPENA), UiTM 2010

All rights reserved. No part ofthis pubtication mav be reproduced. copied, storedin any'retrieval s.vstem or transmitted in any form or by an1,'means - electronic.mechanical. photocopl,ing. recording or otherr.vise. rvithout prior permissionin rvritting from the Director of Unlversitl, Publication Centre (UPENA).Universiti Teknologi MARA. 40450 Shah Alam. Selangor Darul Ehsan. Malal.sia.e-rnai1: upena,?salam.uitm.edu.mv

Perpustakaan Negara Mala1,sia Catalo guing-in-Publication Data

International Conf-erence and Exhibition on Pharmaceutical Nuffaceuticaland Cosmeceutical Technology Forrnulation andApplications (2010 :

Kuala Lumpur)Abstract proceedings ollnternational Conference and Exhibitionon Pharmaceutical Nutraceutical and Cosmeceutical Technolosr, :

lormulat ion and appl ications.rsBN 978-967-363-057-8i. Pharmaceutical Industry,Technological Innovations Malal,sia Congresses.2. Pharmaceutical Technologl, Malal,sia Congresses. I. Exhibition onPharmaceutical Nutraceutical and Cosmeceutical Technologl, FormulationandApplications (2010 : Kuala Lumpur).338.476r5r9

Coverdesign : Pirel Creative SdnBhdTypesetting : Halariza HamdanT1'peface : Times Nerv RomanT1'pesize :11/15

Printed in Malaysia b1, : Ampang Press Sdn. Bhd.6 Jalan 6/91. Taman Shamelin PerkasaBatu 3%. Jalan Cheras.56100 Kuala Lumpure-mail : ampress @streamvx.com

t-

CONTENTS

Acknowledgments

Message from the Vice Chancellor, UiTM

Message from the Assistant Vice Chancellor, UiTM

Message from the Organizing Chairmqn, PharmaTech 2010

Programme

Organizing Committee

l{ational Advisory Board

Plenary Lectures

lnvited Lectures

Industry Lectures

Oral Presentations

Poster Presentations

Advertisements

l-4

5-11

13-16

17 -42

43 - 110

111 - 119

l

tt

ACKNOWLEDGMENTS

Gold Sponsors

Chemopharm Sdn Bhd

Perkin Elmer Sdn BhdDKSH Technology Sdn Bhd

Academy of Sciences Malaysia

Amar Travel and Tours Sdn Bhd

Atrish Technic Services Sdn Bhd

BizConnexion Sdn Bhd

CrestNanoSolutions (M) Sdn Bhd

DG Global Enterprise

Dutech Scientific (M) Sdn Bhd

Genova Technology

Histocenter (M) Sdn Bhd

HolidaycityInterscience Sdn Bhd

Jeol (M) Sdn Bhd

Kotra Pharma Sdn Bhd

Kuala Lumpur Convention Centre

LabAlliance SdnBhd

Lab Science Solution SdnBhdLavender Holidays and Management Sdn Bhd

Maxsains System Enterprise

QES ([sia-Pacific) Sdn Bhd

Researcll Management Institute

Roche Diagnostics (M) Sdn Bhd

SciBiz SdnBhd

Straits Scientific (M) Sdn Bhd

St Scientific Enterprise

Team Medical and Scientific Sdn BhdTefarco Innova Consorzio/BioPharmaNet

Universiti Teknologi MARAExhibitors, participants, presenters, speakers and chairs

Abstract reviewers, webpage engineer, graphic artists, Bendahari uiTM zon lT,UPENA

Colleagues, friends and family

MESSAGE FROM THE VICE GHANGELLOR, U|TM

It is only fitting that heartiest congratulatory notes are expressed here to the organisers ofthis debut

conference for their collaborative initiative in bringing together experts and stakeholders from across

continents to share knowledge on the latest advances, explore new horizons and broaden access to

areas closely linked to pharmaceutical, nutraceutical and cosmeceutical technology.

Hence, I would like to commend the Non-Destructive Biomedical and Pharmaceutical Research

Centre, as well as the Particle Design Research Group - both from the Faculty of Pharmacy, UiTM, the

Academy of Sciences Malaysia, and their Europe-based partners BioPharmaNet and Tefarco Innova

Consorzio, for making possible this coming together of prominent figures to our doorstep and onto our

home turf. Words of appreciation are also in order to supporting bodies, various sponsors and media for

making this event worthy of their time and resources and thus translating ideas into reality.

I understand that the conference provides a meeting point for integrating scientific knowledge on

drug, nutraceutical, as well as cosmeceutical delivery from numerous perspectives, namely, dosage form

design, material synthesis, formulation, processing technology, in-vitro arrd in-vivo characterisation.

Thus, this meeting of minds serves to provide an opportunity for foreign and Malaysian participants alike

to share research findings, establish network, pursue further education, and identifr industry partners for

purposes of commercialisation and business matching.

Through such well thought-out plan of work, I am confident that the objectives of PharmaTech

2010 to attractdelegates from the academia, industries and research institutions across the globe will be

fulfrlled. I am also hopeful that this conference will pave the way towards linking scientists and industrialists,

to subsequently work on creating new projects, providing new insights and information, as well as,

exchanging new ideas to overcome the multifaceted challenges faced by both today. Indeed, collaborative

efforts involving scientists and industrialists can greatly help reap rewards for their respective national

economies, insofar as pharmaceutical, nutraceutical and cosmeceutical arenas are concerned.

Therefore, it is with great pleasure that I wdlcome everyone present to our X'irst International

Conference and Exhibition on Pharmaceutical, Nutraceutical and Cosmeceutical Technology

(PharmaTech 2010), in Kuala Lumpur.

To all our foreign guests - presenters and participants - I wish you a pleasant stay in Malaysia and

hope that this will not be the last that we see of you here in our country. To all our home participants, I

hope that these three days of sharing session will lead to further exploration of new ideas, improved

cross-continental joint-venfures, and renewed endeavours to make this world a better place for all mankind.

DAIO' PROF. IR. DR. SAHOL HAMID BIN ABU BAKAR, FASC.

Universiti Teknolo gi MARA

MESSAGE FROM THE ASSISTANT VICE CHANCELLOR, UITM

I bid a warm welcome to distinguished speakers and participants of the International Conference and

Exhibition on Pharmaceutical, Nutraceutical and Cosmeceutical Technology in Kuala Lumpur. This

exhibition is a platform for exhibitors of various technical and commercial backgrounds for all to learn

and network.

It is hoped that pharmaceutical, nutraceutical and cosmeceutical scientists and practitioners of the

world will capture this opportunity to interact and exchange ideas for the better - nurturing the profession

to the vanguard of the disciplines. For one who cannot learn, one cannot change, thus grows one not.

Finally, my heartfelt appreciation to Assoc. Prof. Dr. Wong Tin Wui, the Organising Chairman and

his enthusiastic committee from Non-Destructive Biomedical and Pharmaceutical Research Centre and

Particle Design Research Group, Faculty of Pharmacy, for a job well done.

Have a fruitful conference. Congratulations and best wishes.

PROF. DR. ABU BAKAR ABDUL MAJEED

Assistant Vice Chancellor

Research Management Institute

MESSAGE FROM THE ORGANIZING CHAIRMAN,PHARMATECH 2O1O

Welcome! Thanks for participating in the first International Conference and Exhibition on Pharmaceutical,

Nutraceutical and Cosmeceutical Technology: Formulation and Applications organized by the Non-

Destructive Biomedical and Pharmaceutical Research Centre, together with the Particle Design Research

Group Faculty of Pharmacy UiTM. Starting from the 25ft of May 2010, this event features two plenary

lectures, eight invited lectures, three industry lectures, 39 oral presentations and 1 00 poster presentations.

Ithighlights topics such as drug/nutraceuticaVcosmeceutical formulation, drug discovery physicochemical

andbiological evaluation of dosage form/active, clinicaVconsumer application of active/formulation, material

sciences and processing technology.

The organizing committee has been working hard towards making this event a successful one with

hopes that it can help scaffolding a stimulating academic platform for researchers and industrialists in

presenting and benchmarking their works, exchanging ideas and views, generating new strategies and

development, as well as, transferring knowledge and technolory through intense and thought-provoking

discussion. Here, we wish to record our greatest heart-felt gratitude to the a few supporting bodies and

various sponsors, of which without their support, this event never be well put together. Many thanks to

Tefarco Innova Consorzio (Europe), BioPharmaNet (Europe), Academy of Sciences Malaysia, Research

Management Institute UiTM, sponsors, exhibitors, official media and friends.

The organizing committee hopes that the conference can serve as an academic platform to elevate

the standard of pharmaceutical, nutraceutical and cosmeceutical scipnces. The exhibition, on the other

hand, serves as the first line unit in educating the general public, especially the school students and

university graduates, on information of processing materials, production and analyical technologies, as

well as of end-products related to the development ofphrirmaceuticals, nutraceuticals and cosmeceuticals.

We strongly believe that an early exposure given to our younger generation on processes behind an

effective formulation in manufacturing industr$ and dosage form design research will help foster a

strong sense of interest within them. This, in retirrn, will eventually help them to carve an alternative

exciting career choice.

At last, I hope PharmaTech2Ol0 can achieve all its set objectives. I wish you all a productive yet

academically stimulating experience !

\SSOC. PROF. DR. WONG TIN WUIi-ir"anizing Chairman

PROGRAMME

lnternationalConference and Exhibition on Pharmaceutical, Nutraceuticaland

Cosmeceutical Technology: Formulation and Applications

25-27 MaY 2010

KLCC, Kuala LumPur, MalaYsia

: Registration

: Arrivals of invited guests

: Malaysia's National Anthem "Negaraku" and "UiTM dihatiku"

Doa recital by Ustaz Muhammad Azlan Md Azib

Welcoming speech by the Organizing Chairman

Assoc. Prof. Dr. Wong Tin Wui, UiTM Malaysia

Welcoming speech by the Assistant Vice Chancellor Research UiTM Malaysia

Y. Bhg. Prof. Dr. Abu Bakar Abdul Majeed

Opening speech by the Deputy Vice Chancelior UiTM Malaysia

Prof. Dr. Mohamad Kamal H.l. Harun

DeputyVice-Chancellor (Community and Industrial Networking)

P1enary session - Conference Hall (Session Chair: Wong Tin Wui)

: Plenary lecture by Paolo Colombo, Parma University, Italy (PL-1)

: Token of appreciation presentation ceremony

Group photo session

: Poster session and tea break

25 May 2010

I 00 - 8.45

Opening ceremony - Conference hall

8.+5 - 9.00

e.00 - 9.30

9.30 - 10.15

10.15 - 10.20

t0.20 - t0.45

Tni ited lecture session

10.45 - 11.15

11.15 - 11.45

rr.45 - 12.15

12.15 - 12.45

12.45 - 14.00

- Conference hall (Session Chair: Yvonne TanTze Fung)

Invited lecture by Chan Lai Wah, National University of Singapore- Singapore

(IL-1)Invited lecture by Carla Caramella, University of Pavia, Ital1'(lL-2)

Invited lecture by Simon Gaisford, Universitl" of London. UK (IL-3)

Industry lecture b1, Alan Marlin Lewis, Kotra Pharma Sdn Bhd. Mala1'sia (I- 1)

Poster session and lunch break

parallel session I - conference hall (Session chair: Paolo colombo)

. j 00 - 14.30 : Industry lecture by Cordin Arpagaus, Chemopharrn Sdn Bhd. Malaysia (I-2)

-1 r0 - 14.45 : Ol

Aa srmt'r P noc t,t Lttt ic ;s

14.45 - 1s.00

15.00 - 15.1s

15.15 - 15.30

15.30 - 15.45

15.45 - 16.15

o2o3o4o5Poster session and tea break

Parallel session 2 - Conference hall (Session Chair: Panchakshari M Dandagi)

16.1s - 16.30

t6.30 - 16.4s

t6.4s - t7.0017.00 - t7.tsl7.ls - r7.30

17.30 - t7.4s17.45

o6o7o8o9o10ollEnd of session

Parallel session 3 - Parallel meeting room (Session Chair: B Sangameswaran)

14.00 - 14.15

t4.t5 - 14.30

14.30 - 14.4s

14.4s - i5.0015.00 - 1s.15

15.15 - 15.30

1s.30 - 15.45

15.45 - 16.15

ot2o13

o14ol5o16ot7018Poster session and tea break

o19020C2tEnd of session

Parallel session 4 - Parallel meeting room (Session Chair: VH Bhaskar)

26 N[.ay 2010

Plenary session - Conference hall (Session Chair: Chan Lai Wah)

16.15 - 16.30

16.30 - 16.45

16.45 - 17.00

17.00

9.15 - 10.00

10.00 - 10.30

10.30 - 11.00

11.00 - 11.30

11.30 - 12.00

12.00 - 12.30

: Plenary lecture by Elias Fattal, Paris-sud University, France (PL-2): Invited lecture by Paul Heng Wan Sia, National University of Singapore, Singapore(rL-4)

: Poster session and tea break

Invited lecture session - Conference hall (Session Chair: Carla Caramella)

: Invited lecture by Carlo Rossi, University of Perugia,Italy (IL-5): Invited lecture by Halimaton Hamdan, Universiti Teknologi Malaysia, Malaysia(rL-6)

: Invited lecture by Yvonne TanTze Fung, Universiti Sains Malaysia, Malaysia(rL-7)

it

Patr;r,"+rtlr

: Invited lecture by Burhanuddin b. Yeop Majlis, Universiti Kebangsaan Malaysia,

Malaysia 0L-8): Poster session and lunch break

i,rrallel session 5 - conference hall (Session chair: carlo Rossi)

Industry lecture by Boon-Chun Tan, Perkin Elmer Sdn Bhd, Malaysia (I-3)

o22o23C24

C25

C26

Poster session and tea break

parallel session 6 - conference hall (Session chair: Paul wS Heng)

12.30 - 13.00

13.00-14.00

14.00 - 14.30

t1.30 - 14.45

14.45 - 15.00

15.00 - 15.15

15.i5 - 15.30

15.30 - 15.45

15.45 - 16.15

r6.i5 - 16.30

16.30 - 16.45

16.45 - 17.00

17.00

Parallel session 7 - Parallel meeting room (Session Chair: K llango)

o27

o28o29Farewell and award ceremony (Conference hall)

03003lC32

033

034035

036Poster session and tea brbak

C31

038039Farewell and award ceremony (Conference hall)

Trade exhibition (Exhibition hall)

14.00 - 14.15

14.15 - 14.30

14.30 - 14.45

14.45 - 15.00

1s.00 - 15.15

15.15 - 15.30

15.30 - 15.45

15.45 - 16.15

Parallel session 8 - Parallel meeting room (Session Chair: K Noorsal)

16.15 - 16.30

i6.30 - 16.45

r 6..+5 - 17.00

17.00

25-27 May 2010

1 0.00- 18.00

25-27 May 2010

1 0.00-18.00 : Career information exhibition (Exhibition hall)

ORGANIZING COMMITTEE

Chairman

Assoc. Prof. Dr. Wong Tin Wui

Secretariat

Nafisah Musa, Nur Zahirah Mohamad Zin, Norizan Hanafi, Nurjaya Sumiran,

Idanawati Naharudin, Aminah Kadir, Noor Jannah Yob, Nor Khaizan Anuar,

Nur Aliza Yahaya, Nagla AM Layas

Committee Members

Publication

Wong Tin Wui, Tan Chong Lip, Johansson Lo De Guzman, Noor Jannah Yob

Logistic

Sharipah Razali, Nurul Hidayah Mohd Salleh, Siti Noorafifah Mohd Zolkefpeli,

Lidawati Zakaria. Nagla AM Layas. Norizan Hanafi, Nur Aliza Yahaya,

Noorshim ari za A sh iki n Wan H us s in . Zabliza Zakar ia

Technical

Syed MohamadAl-Azi Syed Othman. MohammadTarmizi Mohd MokhtalNorAfidah Othman, Assad Ali far:aj Elyagoby, Mohd Hafizul Kamaruzaman

Prf;itocol

Nor Amlizan Ramli, Nurulaini Harioh

Exhibition (career information booth)

Meor Mohd Redzuan Meor Mohd Affandi. Ossama Helweh

Transport

Idanarvati Naharudin, NorAmlizan Ramli, Nurjaya Sumiran, Sharipah Razali.

Syed MohamadAl-Azi Syed Othman

Social

Mohammad TarmiziMohd Mokhtar. AznidaAlias. Ekha Mardziah Radman

NATIONAL ADVISORY BOARD

Prof. Dr. Abu BakarAbdul Majeed, Universiti Teknologi MARA

Prof. Dr. Aishah Adam, Universiti Teknologi MARA

Assoc. Prof . AzizanbinAziz,Universiti Sairis Malaysia

DrAzmi Haji Idris, SIRIM Berhad

Prof. Dr. Burhanuddin b. Yeop Majlis, Universiti Kebangsaan Malaysia

Prof. Dr. Halimaton Hamdan, Universiti Teknologi Malaysia

Dr Ignacio Segarra, International Medical University

Dr Kartini Noorsal, SIRIM Berhad

Assoc. Prof. Dr. Law Chung Lim, The University of Nottingham, Malaysia Campus

Assoc. Prof. Dr. Mohd Cairul Iqbal b. MohdAmin, Universiti Kebangsaan Malaysia

Prof. Dr. Mohd Nasir Taib, Universiti Teknologi MARAProf. Dr. Yvonne TanTze Fung, Universiti Sains Malaysia

AastnryPnocatbtNcs

30' 60' 90 and 120 minutes of administration. Putri nralu extract showed dose-dependent action in all theexperimental models' These results suggested that Putri malu extract has antiinflammatory and analgesicproperties.

o-32

TEST OF ANTIBACTERIAL ACTMryAND INHIBITIONMECHANISM OF EXTRACT MIXTURE OF PiPEihEtIEL,

uncaria gambir,AND cALcruM HyDRo*roe oruStaphylococcus epiderm i d is

Muhammad yanis MusdjaPharmacy Depaftment, Faculty of Medicat and Heatth Scienceg

lslamic State tJniversity Syarif Hidayatullah Jakaftayanisuin@yahoo.com

The mixture of betel (Piper betlel) leaf gambier (tlncaria gambi)and slaked lime (calcium hydroxide)has been used as one of the traditional medicines in Indonesia and other countries for a long time,specifically as an anti-microbial agent. Generally, the mixture of extracts is consumed by chewing in itsnatural raw condition along with many other ingredients like areca nut, cardamom and others. Thepresent studyaimedto evaluate antibacterial activityand inhibitionmechanism ofmixture ofbetel, gambierand slaked lime in a ratio of 2:r:7 on staphylococcus epidermidis with measurement on leakage of K*and c* using atomic absorption spectrometry technique, leakage of proteln and nucleic acid using lrvspectrophotometry technique and alteration of bacterial cell wall using scanning electron microscope.The concentrations of mixture used were 0.5,0.25,0.125,0.063, 0.032,0.016, 0.00g and 0.004%(w/v).The minimal inhibition concentration was about o-25%(dv) of mixture. The leakage tests of protein,nucleic acid' K* and ca2* indicated that increasing conpentration of mixture was found to enhance itsantibacterial activity. t

t

o-33

ALKALI N E p H os p HATAS E AcTrvtry oF G ra pto p hy t I u mp i ctu m AND s p i r a nth es ac mel/a F RAGTI o N S ncru ru rs

MC3T3.E1 CELLS AS MARKER OF OSTEOBLASTDIFFERENTIATION CELLS

Retno Widyowati

Pharmcognosy and phytochemistry Department, Facurty of pharmacy,Jl. Dharmawangsa daram 60296 surabaya, surabaya, rndonesia

ret n o_b i ote k@y a h oo. co m

osteoporosis, one of major diseases of our aging society, results in bone fracture andparalyzation inoldster' especially in post-menopausal women. Anabolic skeletal agents affect processes primarily

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