p p p p e p p f f f f f f p f f r p p f p f p f
p e p p p p f f f f f p p p p cf cf p p f f f p f
p p p f p f p e p f f w r f r cf p f p f p f p e
p p p p p e p p p cl cl w w r e p p p f f p f e r
p p p p e f p p w w f p f r e p p p f f f f f r
p p p p e p p p p p p p f p p f f p p f f f f f
p p p p p p p p p p p p f p p p f p p p f p f p
p p p p p p p p p p p p p p p f f p f p e p f f
p p p p p p p p p p p p p p p f p p p p p p p p
p p p p p f p p p p p p p p p p f p p p f p f p
p f f p p p p p p p p p p p p p p p p p e e f f
p p e p p f p p p p p f p p p p p p p p f p p p
p p f p f f f p p p p p p p p p e e p f p p p p
p p p p p p f p p p p p p p e p f e r f p p p p
p p p p p p p p e p p p p p e f p p r p p p p p
p e p p p p p p w p p f p p e e f p p p p p p p
111111
FibrinCholesterol Mix Cell-Fibrin
LeukocytesErytrocytesPlatelet
Exemple = 1 Image
LIMITATIONS
1- Analysis of the main aspirated piece of the thrombus only
2- Potential distortion during thrombo-aspiration
3- Younger thrombus could be superimposed with an older one
4- No increase of the % of erythrocytes with time (“Red Thrombi”)
A crucial role for early anti-thrombotic treatment
Platelet and thrombin inhibition with fast acting drugs especially in early presenters <3 hours
Conclusion
First human confirmation of the generally accepted pathogenesis of clot formation in vivo in patients presenting an acute coronary thrombosis (STEMI).
(n=911)
A potential prognostic marker that is linked to short and long-term mortality in previous study (Kramer et al. Circulation 2009)
Did not impact reperfusion in this limited size mechanistic study
Highlight the crucial role of fast-acting platelet and thrombin inhibitor in STEMI presenters