FINAL PROGRAM · 2018-09-01 · 3 03 Committees 04 Welcome Message 05 Acknowledgements 06 Program...

1www.cytokines2016.com

4TH MEETING OF THE INTERNATIONAL CYTOKINE

AND INTERFERON SOCIETY (ICIS)16-19 october 2016, San Francisco, CA, USA

Cytokines and interferons: master controllersof immunity, inflammation, metabolism and cancer

www.cytokines2016.com

FINAL PROGRAM


03 Committees

04 Welcome Message

05 Acknowledgements

06 Program Overview

08 Scientific Program

Sunday, 16 October 2016


Monday, 17 October 2016


Tuesday, 18 October 2016


Wednesday, 19 October 2016

14 Poster Presentations

27 Awards Winners

29 Company Profiles

32 Layout of Venue & Exhibition Area

33 General Information

35 Networking events

Meeting ChairsDavid Artis (Cornell)John O’Shea (NIH)Erika Pearce (MPI)

ICIS Scientific CommitteeDavid Artis (USA)Xuetao Cao (China)Dan Cua (USA)Sarah Gaffen (USA)Wendy Garret (USA)Nicola Harris (Switzerland)Jorge A. Henao-Mejia (USA)Kenya Honda (Japan)Christopher Hunter (USA)Susan Kaech (USA)Axel Kallies (Australia)Luke O’Neill (Ireland)John O’Shea (USA)Wenjun Ouywang (USA)Erika Pearce (Germany)Dana Philpott (Canada)Amariliz Rivera-Medina (USA)

TABLE OF CONTENTS

COMMITTEES

4 www.cytokines2016.com

Dear Meeting Attendees,

We would like to welcome you to Cytokines2016, the 4th Annual Meeting of the International Cytokine and Interferon Society (ICIS).

The objective of the meeting is to promote interactions between scientists performing cutting-edge studies of the molecular mechanisms of cytokine and interferon function, signal transduction, and gene expression in the context of health and disease. Working with the scientific advisory committee composed of leading investigators from academia and industry, an outstanding scientific program is planned.

The Keynote speaker this year is Dr Yasmine Belkaid from the National Institutes of Health. Dr Belkaid is a world-leader in the areas of cytokine regulation of host defense, inflammation and tissue protection. Her research has spanned areas of immunity to infection, host-microbiota interactions and regulation of effector and regulatory T cell function. Dr Belkaid is an outstanding speaker and an excellent colleague to launch the 2016 meeting.

Each day of the meeting will begin with an exciting plenary session, topics include inflammation and cancer, mechanisms of host defense and regulation of innate and adaptive immunity. Additional major- and mini-symposia will cover topics including microbiota-immune interactions, cytokine regulation of cellular metabolism, epigenetic regulation of cytokine signaling, interferons and host defense, innate immunity, cytokines and metabolic disease, primary immuno-deficiencies, innate lymphoid cell biology and to the clinic - emerging therapies. There will also be multiple venues to promote networking for trainees and junior faculty with established investigators and representatives from academic institutions, biotech, pharma and scientific journals.

On behalf of all participants, we would like to express our gratitude to the meeting’s Sponsors and Exhibitors. The dissemination of knowledge that takes place at such meetings and the interactions and collaborations that are established are essential for future advances in biomedical research. Successful meetings simply would not be possible without substantial support from the NIH, industry, foundations, and institutes.

We look forward to an outstanding scientific program and the development of fruitful interactions and collaborations among all attendees.

David Artis, PhDJohn O’Shea, MDErika Pearce, PhD

WELCOME MESSAGE


ACKNOWLEDGEMENTS

The Cytokines 2016 Organising Committee wishes to express its gratitude to the following industry partners for their support of the meeting:

Platinum sponsor

Gold sponsors

Silver sponsor

Bronze sponsors

Sponsors

Exhibitors

Farbe/colour:PANTONE 288 CVThis activity was supported by an educational grant from Celgene Corporation


PROGRAM OVERVIEW


ROOM

TIMEGRAND BALLROOM A

16:00 - 16:15 WELCOME ADDRESS

16:15 - 17:40 AWARD PRESENTATIONS

17:40 - 18:40 KEYNOTE PRESENTATION

18:45 WELCOME RECEPTION & NETWORKING


ROOM

TIMEGRAND BALLROOM A GRAND BALLROOM B/C SEACLIFF A-C

08:30 - 10:30IMMUNE REGULATION

OF INFLAMMATION AND CANCER

10:30 - 11:00 COFFEE BREAK

11:00 - 13:00THE MICROBIOTA AND REGULATION OF INFLAMMATION

CYTOKINE REGULATION OF METABOLISM

13:00 - 14:00LUNCHTIME TRAINEE

CAREER PANEL DISCUSSION

13:00 - 15:00 VISIT OF THE EXHIBITION AND POSTERS

15:00 - 17:00TO THE CLINIC:

EMERGING THERAPIES

INTERFERONS: REGULATORS OF IMMUNITY

AND INFLAMMATION

17:00 - 19:00 POSTERS VIEWING WITH PRESENTERS

19:30 - 21:30 EVENING TRAINEE NETWORKING EVENT



ROOM

TIMEGRAND BALLROOM A GRAND BALLROOM B/C

08:30 - 10:30INNATE AND ADAPTIVE IMMUNE MECHANISMS OF HOST DEFENSE


11:00 - 13:00 CYTOKINES AND METABOLIC DISEASES INNATE IMMUNITY AT BARRIER SURFACES

13:00 - 15:00 VISIT OF THE EXHIBITION

13:30 - 15:00 POSTER VIEWING WITH PRESENTERS

14:00 - 14:45 ICIS-BIOLEGEND BILL PAUL AWARD

15:00 - 17:00THE JICR/MARY ANN LIEBERT, INC.

SYMPOSIUM IN HONOR OF PHILIP I. MARCUS

PRIMARY IMMUNODEFICIENCIES: LESSONS FOR CYTOKINE

AND INTERFERON BIOLOGY

17:30 - 19:30 ICIS FAREWELL RECEPTION (UPON REGISTRATION)


ROOM

TIMEGRAND BALLROOM A GRAND BALLROOM B/C

08:30 - 10:30CYTOKINES AND ORCHESTRATION

OF INNATE AND ADAPTIVE IMMUNITY


11:00 - 13:00INNATE LYMPHOID CELLS:

FIRST RESPONDERS IN IMMUNITY AND INFLAMMATION

TRANSCRIPTIONAL AND EPIGENETIC REGULATION OF CYTOKINE

RESPONSES

13:00 CLOSING OF THE MEETING



16:00 - 18:45 OPENING CEREMONY, KEYNOTE & AWARD PRESENTATIONS Grand Ballroom A

Chairs: David Artis, USA - Tadatsugu Taniguchi, Japan

16:00 - 16:15 WELCOME ADDRESSWelcome address from Cytokines 2016 ChairDavid Artis, Weill Cornell Medicine, USA

16:15 - 17:55 AWARD PRESENTATIONS

16:15 ICIS President’s welcome message and award presentationsTadasu Taniguchi, The University of Tokyo, Japan

16:20 Milstein Young Investigators (presented by E.N. Fish and J. Towne)Andreas Bergthaler, CeMM, Austrian Academy of Sciences, Austria Si Ming Man, St. Jude Children’s Research Hospital, USADi Yu, Monash University, AustraliaVineet D. Menachery, University of North Carolina, USA

16:30 Christina Fleischmann Award (presented by R. Fleischmann)Michelle D. Tate, Hudson Institute of Medical Research, Australia

16:40 Pestka Graduate Award (presented by R. Pestka)Rhiannon Werder, University of Queensland, Australia

Pestka Post Graduate AwardScott Read, Westmead Institute for Medical Research, Australia

16:50 2016 Milstein Award (presented by T. Taniguchi)John O’Shea, NIAMS/NIH, USACarl Nathan, Weill Cornell Medical College, USAJan Vilcek, New York University School of Medicine, USA

17:00 2016 Milstein Award LectureCarl Nathan, Weill Cornell Medical College, USA

17:30 2016 Honorary Life Membership Award (presented by T. Taniguchi)Howard Young, National Cancer Institute, NIH, USA

17:40 - 18:40 KEYNOTE PRESENTATION

Microbial control of tissue immunity Yasmine Belkaid, NIH, USA

18:45 Welcome reception & Networking Exhibition area

SCIENTIFIC PROGRAM



08:30 - 10:30 IMMUNE REGULATION OF INFLAMMATION AND CANCER Grand Ballroom A

Chairs: Fiona Powrie, UK - Steven Ziegler, USA

08:30 Why so many ways to die? The non-canonical inflammasome pathwayVishva Dixit, Genentech, USA

09:00 O001 - Discovery of a novel transcriptional regulator of sustaining TLR-mediated inflammatory responsesBin Lin, Bethesda, USA

09:15 New aspects of the regulation of inflammatory responses in the gutTadatsugu Taniguchi, The University of Tokyo, Japan

09:45 O002 - Transgene expression of interleukin-37 in IL-10KO mice inhibits colon carcinogensisPhilip Bufler, Ludwig-Maximilians-University, Munich, Germany

10:00 Cytokines and inflammation in colorectal cancerMichael Karin, UCSD, USA

10:30 - 11:00 Coffee break Exhibition area

11:00 - 13:00 THE MICROBIOTA AND REGULATION OF INFLAMMATION Grand Ballroom A

With the kind support of an unrestricted educational grant from Amgen

Chairs: Yasmine Belkaid, USA - Sarah Gaffen, USA

11:00 Gut microbiota in immune activationKenya Honda, Keio University School of Medicine, Tokyo, Japan

11:30 O003 - Effects of microbiota dysbiosis during intestinal inflammationIrina Leonardi, Weill Cornell, USA

11:45 Gut reactions: Immune pathways in the intestine in health and diseaseFiona Powrie, Kennedy Institute of Rheumatology University of Oxford, UK

12:15 O004 - Microbiome-dependent modulation of mucosal immunity at the ocular surfaceAnthony J. St. Leger, NIH, USA

12:30 Regulation of host immunity by helminth-microbiota interactionsNicola Harris, EPFL, Switzerland

11:00 - 13:00 CYTOKINE REGULATION OF METABOLISM Grand Ballroom B/C

Chairs: Richard Locksley, USA - Wenjun Ouyang, USA

11:00 Maternal antibodies regulate neonatal immunityMeghan Koch, UC Berkeley, USA

11:30 O005 - LKB1 haploinsufficiency in T cells is sufficient to drive the development of Peutz-Jeghers syndromeMaya Chikako Poffenberger, McGill University, Canada

11:45 Innate licensing of thermogenesisAjay Chawla, UCSF, USA

12:15 O006 - Complex regulation of TNF expression controlled by the 3’ untranslated regionPhilippe Bouillet, The Walter And Eliza Hall Institute, Australia

12:30 T cell metabolismErika Pearce, MPI, Germany


13:00 - 15:00 Lunch break, posters, visit of the exhibition Exhibition areaCoffee and tea will be served in the exhibition at 14:30

13:00 - 14:00 Lunchtime Trainee Career Panel Discussion Seacliff A-CFor trainees only

Dr. Dhaval Patel, Head NIBR, Europe at Novartis, Basel Switzerland

Dr. John Foley, Managing Editor, Science Signaling

Dr. Mandy McGeachy, Assistant Professor, University of Pittsburgh (formerly, DNAX/Merck)

Dr. David Finkel, R&D Systems, Marketing Campaign Manager, Bio-Techne

Dr. Laura Wilson, Director of Health, Strategy & Ventures, Kenneth Rainin Foundation

Dr. Jennifer Towne, Senior Scientific Director, Immunology Discovery, Janssen Research & Development LLC

15:00 - 17:00 TO THE CLINIC: EMERGING THERAPIES Grand Ballroom A

Chairs: Steven Ziegler, USA - Cem Gabay, Switzerland

15:00 Targeting the TH17 immune axis: from mechanisms to clinical testingDan Cua, Merck, USA

15:30 O007 - Low-dose interleukin-2 treatment modulates CD4+ T cell subsets selectively in patients with systemic lupus erythematosusDi Yu, Monash University, Australia

15:45 Regulation of type-2 inflammationSteven Ziegler, Benaroya, USA

16:15 O008 - Targeting the IL-7R pathway in leukemia with JAK inhibitors and mAbsScott Durum, National Cancer Institute, USA

16:30 IL-17 targeted therapiesDhavalkumar Patel, Novartis, Switzerland

15:00 - 17:00 INTERFERONS: REGULATORS OF IMMUNITY AND INFLAMMATION Grand Ballroom B/C

With the kind support of an unrestricted educational grant from MedImmune (AstraZeneca)

Chairs: Eleanor Fish, Canada - Amariliz Rivera, USA

15:00 Transcriptional regulation of IL-10 and pro inflammatory cytokines in T helper cellsAnne O’Garra, Crick, UK

15:30 O009 - Interferon-driven metabolic reprogramming of hepatocytesAndreas Bergthaler, CeMM, Austrian Academy of Sciences, Austria

15:45 Antiviral signaling at the maternal-fetal interfaceCarolyn Coyne, UPitt, USA

16:15 O010 - IFNAR signaling of myeloid cells modulates viral hepatitis but not kupffer cell replenishmentKatharina Borst, TWINCORE GmbH, Hannover, Germany

16:30 Distinct contributions of Type I and III IFNs to innate antifungal immunityAmariliz Rivera, Rutgers, USA

17:00 - 19:00 Official poster viewing and presentations Poster area

19:30 - 21:30 Evening Trainee Networking Event Market street foyerFor trainees only



08:30 - 10:30 INNATE AND ADAPTIVE IMMUNE MECHANISMS OF HOST DEFENSE Grand Ballroom A

Chairs: Dana Philpott, Canada - Peter Staehli, Germany

08:30 Role of early T-bet in T cell activationChristopher Hunter, UPenn, USA

09:00 O011 - A “rheostat” function for the GP130/STAT3 signaling cascade for gastrointestinal wound-healing and tumorigenesisMatthias Ernst, Olivia Newton-John Cancer Research Institute, Australia

09:15 Autophagy in the control of intracellular infectionDana Philpott, UToronto, Canada

09:45 O012 - IL-17RA signaling in oral epithelium is necessary and sufficient for protection against oropharyngeal candidiasisSarah Gaffen, University of Pittsburgh, USA

10:00 Interferon Receptor inhibitors, and the role of IgE in SLEMiguel Sanjuan, MedImmune, USA


11:00 - 13:00 CYTOKINES AND METABOLIC DISEASES Grand Ballroom A

Chairs: Erika Pearce, Germany - Jorge A. Henao-Mejia, USA

11:00 Dissect inflammatory pathways in the mucosal immunityWenjun Ouyang, Amgen, USA

11:30 O013 - IL-17A exacerbates psoriasiform dermatitis in a mouse model of high-fat diet-induced steatohepatitisJean-Claude Lecron, Université de Poitiers, France

11:45 Cytokine regulation of immunity and inflammationDavid Artis, Cornell, USA

12:15 O014 - Cardiotrophin-like cytokine (CLCF1) participates in lipoprotein complexesSarah Pasquin, Université de Montréal, Canada

12:30 Cytokines and transcriptional regulators of tissue-resident T cellsAxel Kallies, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia

11:00 - 13:00 INNATE IMMUNITY AT BARRIER SURFACES Grand Ballroom B/C

Chairs: Christopher Hunter, USA - Greg Barton, USA

11:00 Coordinating innate immunity and tissue homeostasisGreg Barton, Berkeley, USA

11:30 O015 - An essential role for epithelial cell histone deacetylase 3 in intestinal host defenseTheresa Alenghat, University of Cincinnati, USA

11:45 Epithelial cells-innate lymphoid cells-Th cells trio-regulation for gut homeostasis and inflammationHiroshi Kiyono, The University of Tokyo, Japan

12:15 O016 - Interferon-lambda controls the spread of respiratory viruses from the upper respiratory tract to the lungs and restricts virus transmission in micePeter Staeheli, University of Freiburg, Germany

12:30 Crosstalk between mycobiota and host immunity during fungal dysbiosisIliyan Iliev, Cornell, USA


13:00 - 15:00 Lunch break, visit of the exhibition Exhibition areaCoffee and tea will be served in the exhibition at 14:30

13:30 - 15:00 Official poster viewing and presentations Poster area

14:00 - 14:45 ICIS-BIOLEGEND BILL PAUL AWARD Grand Ballroom A

Chairs: John O’Shea, USA - Weiping Jiang, USA

14:00 IntroductionWeiping Jiang, Biomarker Discovery, USA

14:15 New pathways in type 2 immunityRichard Locksley, UCSF, USA

15:00 - 17:00 THE JICR/MARY ANN LIEBERT, INC. SYMPOSIUM IN HONOR OF PHILIP I. MARCUS Grand Ballroom A

Chairs: Thomas Hamilton, USA - Ganes Sen, USA

15:00 New insights into IFN immunity against flavivirusesMichael Diamond, WashU, USA

15:30 O017 - Negative regulation of innate immune signaling by the RNA sensor, LGP2Curt Horvath, Northwestern University, Evanston, USA

15:45 Inhibition of type I IFN signaling by flavivirusesAdolfo Garcia-Sastre, Mount Sinai, USA

16:15 O018 - Loss of autophagy drives inflammation via type I interferonsMohammad Samie, San Francisco, USA

16:30 O019 - Interferon-inducible proteins are essential for the activation of the inflammasomesSi Ming Man, St. Jude Children’s Research Hospital, USA

16:45 Christina Fleischmann Award PresentationMichelle Tate, Hudson Institute of Medical Research, Australia

15:00 - 17:00 PRIMARY IMMUNODEFICIENCIES: LESSONS FOR CYTOKINE AND INTERFERON BIOLOGY Grand Ballroom B/C

Chairs: John O’Shea, USA - Nancy Reich, USA

15:00 Toward a genetic theory of childhood infectious diseasesJean-Laurent Casanova, Rockefeller, USA

15:30 O020 - The lab environment recapitulates primary human immune responses in miceWaleed Elsegeiny, Children’s Hospital of Pittsburgh, USA

15:45 New precision medicines emerge from gene identification in congenital immune disordersMichael J. Lenardo, NIH, Bethesda, USA

16:15 O021 - Familial autoinflammation with neutrophilic dermatosis reveals a novel regulatory mechanism of pyrin activationPaul J. Baker, University of Melbourne, Australia

16:30 O022 - STING-dependent cytokine signaling manifests self DNA induced autoinflammatory diseaseJeonghyun Ahn, University of Miami, USA

16:45 The Sidney & Joan Pestka Post Graduate Award presentationsScott Read, Westmead Institute for Medical Research, Australia

17:30 - 19:30 ICIS Farewell Reception La Mar RestaurantUpon registration



08:30 - 10:30 CYTOKINES AND ORCHESTRATION OF INNATE AND ADAPTIVE IMMUNITY Grand Ballroom A

Chairs: Anne O’Garra, United Kingdom - Greg Sonnenberg, USA

08:30 Human Th cell subsets in immunity, autoimmunity and immunodeficienciesFederica Sallusto, IRB, Switzerland

09:00 O023 - IL-27 induced by select candida spp. via TLR7/NOD2 signaling and IFN-B production inhibits fungal clearanceSelinda J. Orr, Cardiff University, UK

09:15 Oxysterols as regulators of immunityJason Cyster, UCSF, San Francisco, USA

09:45 O024 - Homeostatic stat5 signaling drives accumulation and function of innate lymphocytesAlejandro Villarino, NIAMS, Bethesda, USA

10:00 Long non-coding RNAs and the homeostasis of innate immune cellsJorge A. Henao-Mejia, UPenn, Philadelphia, USA


11:00 - 13:00 INNATE LYMPHOID CELLS: FIRST RESPONDERS IN IMMUNITY AND INFLAMMATION Grand Ballroom A

Chairs: Shigeo Koyasu, Japan - Meghan Kochs, USA

11:00 Immune regulation of intestinal healthGreg Sonnenberg, Weill Cornell, USA

11:30 O025 - Innate lymphoid cell function in allergic inflammation: Arginase 1 is a critical metabolic checkpoint controlling type 2 inflammationLaurel A. Monticelli, Weill Cornell, USA

11:45 Innate lymphoid cells promote organ homeostasisAndreas Diefenbach, Johannes Gutenberg-Universität Mainz, Germany

12:15 O026 - Regulation and function of the type 2 immune module in adipose tissueAri Benjamin Molofsky, University Of California, USA

12:30 Regulatory mechanisms for ILC2 activation in allergic inflammationShigeo Koyasu, RIKEN, Japan

11:00 - 13:00 TRANSCRIPTIONAL AND EPIGENETIC REGULATION OF CYTOKINE RESPONSES Grand Ballroom B/C

Chairs: Jennifer Towne, USA - Daniel Mucida, USA

11:00 LC3-associated phagocytosis: Two ancient pathways collide in the regulation of cytokinesDouglas Green, St. Jude Children’s Research Hospital, USA

11:30 O027 - Elucidating the epigenetic regulation of CD4+ T cell derived IL-10 during influenza infectionNicolette Fonseca, University of British Columbia, Vancouver, Canada

11:45 Tissue adaptation: Implications for gut immunity and toleranceDaniel Mucida, Rockefeller, USA

12:15 O028 - Immune-restricted epigenetic reader sp140 maintains transcriptional programs required for macrophage identity and intestinal homeostasisKate L. Jeffrey, Harvard, USA

12:30 Cytokine signaling and genomes and 2016 Milstein Award LectureJohn O’Shea, NIH, Bethesda, USA

13:00 CLOSING OF THE MEETING Grand Ballroom A

John O’Shea, NIH, Bethesda, USA Kouji Matsushima, The University of Tokyo, Japan


Monday, 17 October 2016 - 17:00 - 19:00, Poster area

Immune regulation of inflammation and cancer I

P001 IFN-Λ4 HAS A POTENT ANTIPROLIFERATIVE ACTIVITY IN B-CELL LYMPHOMA AND HEPATOMA CELL LINES / A. Obajemu*, O. O. Onabajo, N. Rao, R. Banday, L. Prokunina-Olsson (USA)

P002 HCV CORE PROTEIN TRIGGERS IL-1B PRODUCTION VIA THE NLRP3 INFLAMMASOME / A. A. Negash*, L. D. Aarreberg, R. M. Fritzemeier, M. J. Gale, Jr. (USA)

P003 REGULATION OF THE CCL2-CCR2 AXIS THROUGH THE JAK-STAT PATHWAY AND ROLE IN CANCER METASTASIS / A. Rani*, R. Greenlaw, J. Murphy, C. Galustian (UK)

P004 LOSS OF IRF5 INDUCES SPONTANEOUS MAMMARY TUMORIGENESIS / D. Li, X. Bi, C. Goyeneche, A. Pitler, B. Barnes* (USA)

P005 PROTEOLYTIC ORIGIN OF THE SOLUBLE HUMAN IL-6R IN VIVO AND A DECISIVE ROLE OF N-GLYCOSYLATION / C. Garbers*, S. Riethmueller, P. Somasundaram, J. C. Ehlers, T. Koudelka, C.-W. Hung, A. Tholey, S. Rose-John (Germany)

P006 DISTINCT ROLES FOR IRF5 IN MAMMARY EPITHELIAL CELLS AND HOST TUMOR IMMUNITY: LOSS OF IRF5 IN EITHER COMPARTMENT LEADS TO TUMORIGENESIS / D. Li*, B. Barnes (USA)

P007 SEXUALLY DIMORPHIC ROLES OF STAT3 IN PEDIATRIC BRAIN CANCER / C. White, S. Jayasekara, J. Cain, D. Gough* (Australia)

P008 DISRUPTION OF PD-1/PD-L1 SIGNALING IN 2D VS. 3D COLORECTAL CANCER COCULTURE MODEL REVEALED BY RNAI HIGH THROUGHPUT SCREEN / D. J. Fernandez*, J. Fu, M. Lal Nag (USA)

P009 POLIO VIRUS THERAPY HAS IMMUNOSTIMULATORY PROPERTIES THAT ARE ACTIVE AGAINST SOLID TUMORS / E. Holl*, M. Brown, D. Boczkowski, D. Bigner, M. Gromeier, S. Nair (USA)

P010 SUPPRESSOR OF CYTOKINE SIGNALING 5 LOSS PROMOTES BREAST CANCER / E. Linossi*, L. Dagley, T. Kolesnik, M.-L. Asselin-Labat, J. Visvader, J. Babon, N. Nicola, A. Webb, S. E. Nicholson (Australia)

P011 P-ERK ACTIVATION THROUGH P70S6 KINASE PHOSPHORYLATION CORRELATES WITH AUTOPHAGY ON MELANOMA CELL LINES / E. Toniato*, V. De Iuliis, M. Caruso, A. Marino, A. Saggini, C. Talora, V. Flati, S. Martinotti (Italy)

P012 THE ROLE OF GRANULOCYTE-COLONY STIMULATING FACTOR IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE / E. Tsantikos*, M. Lau, M. Maxwell, G. Anderson, M. Hibbs (Australia)

P013 CYTOKINE-DRIVEN LOSS OF PLASMACYTOID DENDRITIC CELL FUNCTION IN CHRONIC LYMPHOCYTIC LEUKEMIA / D. Saulep-Easton, F. Vincent, M. Le Page, A. Wei, S. Ting, C. Croce, C. Tam, F. Mackay* (Australia)

P014 EXPLORATION OF IFNLR1-DEPENDENT AND INDEPENDENT CANCER-RELATED FUNCTIONS OF IFN-Λ4 IN A HEPATOMA CELL LINE / F. Wang*, O. O. Onabajo, L. Prokunina-Olsson (USA)

P015 INFLAMMATORY MICROENVIRONMENT AND HUMAN PAPILLOMAVIRUS-INDUCED CARCINOGENESIS / G. Romeo*, G. Mangino, M. V. Chiantore, G. Fiorucci, M. Iuliano (Italy)

P016 DEREGULATION OF STING SIGNALING IN COLORECTAL CARCINOMA CONSTRAINS DNA-DAMAGE RESPONSES AND CORRELATES WITH TUMORIGENESIS / H. Konno*, T. Xia, J. Ahn, G. N. Barber (USA)

P016-b APOBEC MUTAGENESIS: A NEW LINK BETWEEN INNATE IMMUNITY AND CANCER / R. Banday, O. O. Onabajo, K.-I. Udquim, M. Marquez-Palencia, A. Obajemu, C. D. Middlebrooks, L. Prokunina-Olsson* (USA)

P016-d FLOW-BASED, CELL TYPE-SPECIFIC MULTIPLEX ASSAY PANELS AS USEFUL TOOLS FOR INNATE AND ADAPTIVE IMMUNITY RESEARCH / B. Sun, P. Rughwani, S. Ji, W. Jiang* (USA)

P016-e ONCOSTATIN M INDUCES ARGINASE 1 + MACROPHAGE ACCUMULATION IN MURINE MODELS OF AIRWAY INFLAMMATION AND CANCER GROWTH, BUT ACTS INDIRECTLY THROUGH ITS INDUCTION OF IL-6 AND IL-4/IL-13 CYTOKINE SIGNALING / A. Dubey, E. Ayaub, L. Izakelian, K. Stephenson, F. Botelho, K. Ask, C. Richards* (Canada)

P016-f XCL1-PRODUCING INVARIANT NKT CELLS PROMOTE ALLERGIC AIRWAY RESISTANCE BY RECRUITING CD103+ DENDRITIC CELLS / D. H. Chung*, Y. D. Woo, H. Y. Kim (Republic of Korea)

POSTER PRESENTATIONS


The microbiota and regulation of inflammation

P017 LACTOBACILLUS AND BIFIDOBACTERIUM TREATMENT CONTRIBUTE TO AN IMMUNOREGULATORY PROFILE THROUGH UP REGULATION OF TGF-Λ/FOXP3 IN EXPERIMENTAL COLITIS IN MICE / R. Toumi, I. Soufli, C. Touil-boukoffa* (Algeria)

P018 EVALUATING THE IMPACT OF A HIGH-ENERGY DIET SUPPLEMENTED WITH FERMENTABLE MATERIAL ON CYTOKINE PROFILES AND OBESITY-ASSOCIATED BIOMARKERS IN SPRAGUE DAWLEY RATS / S. T. Clarke*, M. Kalmokoff, S. P. J. Brooks, J. Green, J. M. Green-Johnson (Canada)

P019 CYTOKINES IN CHRONIC INFECTION OF CENTRAL NERVOUS SYSTEM TUBERCULOSIS / S. Patil* (India)

P019-b GUTTED: THE GUT MICROBIOME AND IMMUNE SYSTEM IN CHRONIC INFLAMMATION / N. West*, J. Vider, B. Fazekas de St Groth, H. McGuire, B. Devereaux, A. Cripps, A. Cox (Australia)

P019-c THE AIM2 INFLAMMASOME SENSOR REGULATES INTESTINAL HOMEOSTASIS THROUGH THE IL-22/STAT3 PATHWAY / R. A. Ratsimandresy*, M. Indramohan, A. Dorfleutner, C. Stehlik (USA)

Cytokine regulation of cellular metabolism

P021 DIFFERENTIAL EFFECTS OF TYPES I AND III IFNS ON SURVIVAL AND GROWTH OF VASCULAR ENDOTHELIAL CELLS AND ANGIOGENESIS / H. Jia*, P. Dilger, C. Bird, M. Wadhwa (UK)

P022 THE LEVEL OF SALIVA CYTOKINES AND AMYLASE OF HEALTHY YOUNG PEOPLE WITH DIFFERENT WATER DRINKING BEHAVIOR / K. Melnik*, G. Baisheva, T. Alpatova (Russia)

P023 REGULATION OF THE INTERFERON-INDUCED EIF2Α KINASE PKR BY TRBP PHOSPHORYLATION / E. E. Chukwurah, R. C. Patel* (USA)

P024 IL-3 ENHANCES OSTEOGENESIS IN PREOSTEOBLASTIC MC3T3-E1 CELLS / S. T. Mhaske*, A. Kumar, V. Piprode, A. P. Barhanpurkar, M. R. Wani (India)

P024-b B CELL DEVELOPMENT REQUIRES DISCRETE REGULATION BY PTEN-PI3K AND MTOR PATHWAYS AND THE INTRICATE INTERPLAY WITH IL-7R-STAT5 SIGNALING / H. Zeng*, H. Chi (USA)

Cytokine signaling and epigenetics

P025 TNF-ΛLPHA RECEPTORS EXPRESSION ON IMMUNE CELLS IN ATOPIC DERMATITIS IS ASSOCIATED WITH DISEASE ACTIVITY / A. A. Alshevskaya*, J. Lopatnikova, O. Krugleeva, V. Nepomnyschih, V. Lukinov, S. Sennikov (Russia)

P026 STRESS-INDUCED DYNAMIC REGULATION OF MITOCHONDRIAL STAT3 AND ITS ASSOCIATION WITH CYCLOPHILIN D / A. Larner*, J. Meier, M. Hyun, M. Cantwell, A. Raza, V. Raje, J. Sisler, K. Takabe, H. Baumann, E. Tracey, P. Shaw, C. Mertens, S. Gispert (USA)

P027 PRIOR CD4 T-CELL ACTIVATION MODIFIES THE SIGNALLING CHARACTERISTICS OF IL-6 / A. Cardus Figueras*, J. P. Twohig, R. Andrews, B. C. Cossins, J. Uceda Fernandez, C. J. Pepper, P. R. Taylor, T. Tiganis, N. M. Williams, G. W. Jones, S. A. Jones (UK)

P028 ROLE OF X-LINKED INHIBITOR OF APOPTOSIS PROTEIN ASSOCIATED FACTOR-1 (XAF1) IN REGULATING TUMOR NECROSIS FACTOR RECEPTOR-1 COMPLEX STABILITY / B. Lin*, D. Xu, D. W. Leaman (USA)

P029 TUMOR NECROSIS FACTOR RECEPTOR-1 (TNFR1) SIGNALOSOME IS INFLUENCED BY JANUS KINASE 2 (JAK2)-MEDIATED RECEPTOR TYROSINE PHOSPHORYLATION / F. Z. Hapil*, M. G. Ertosun, F. E Copuroglu, O. N. Ozes (Turkey)

P030 CYTOKINES AND HEPATOCELLULAR CARCINOMA: POTENTIAL PROGRESSION MARKERS AND CELL TYPE-SPECIFIC MODULATORS OF THE MIRNOME (E.G. INTERLEUKIN-6 AND OTHER JAK/STAT ACTIVATING CYTOKINES) / M. Kirchmeyer*, F. A. Servais, M. Hamdorf, C. Haan, P. Nazarov , L. Vallar, M. Casper, M. Glanemann , A. Arslanow, C. Rubie, F. Lammert, S. Kreis, I. Behrmann (Luxembourg)

P031 POST-TRANSCRIPTIONAL REGULATION OF IL-17-DEPENDENT SIGNAL TRANSDUCTION / N. Amatya*, A. V. Garg, W. Horne, L. P. Kane, J. K. Kolls, U. Atasoy, S. L. Gaffen (USA)

P032 ROLE OF CAMP ACTIVATED PROTEIN KINASE (PKA) IN REGULATION OF TUMOR NECROSIS FACTOR RECEPTOR TYPE I (TNFR1) SIGNALING / F. Z. Hapil, M. G. Ertosun, F. E. Copuroglu, O. N. Ozes* (Turkey)

P033 TRANSCRIPTION FACTORS DIFFERENTIALLY REGULATE A MACROPHAGE IL1B INNATE IMMUNE MEMORY QUORUM RESPONSE DURING A PERIOD OF TNF ENDOTOXIN TOLERANCE / S. H. Pulugulla, J. Adamik, D. L. Galson, P. E. Auron* (USA)


P034 THE IL-22 BINDING PROTEIN ISOFORMS ARE A RHEOSTAT FOR IL-22 SIGNALING / C. Lim, M. Hong, R. Savan* (USA)

P034-b DISTINCT ROLE OF THE TEC KINASE ITK IN HUMAN TREG DIFFERENTIATION / P. Mamontov*, R. A. Eberwine, J. Perrigoue, K. Leonard, A. Das, J. R. Mora, J. R. Friedman (USA)

P034-c Antagonism of MAVS Signaling by Rotavirus Infection/ S. Ding*, H. B. Greenberg (USA)

Interferons: regulators of immunity and inflammation I

P035 MAPPING THE OVERLAPPING AND UNIQUE RESPONSES TO TYPE I AND TYPE III INTERFERON SENSING / A. Forero*, B. Chou, R. Savan (USA)

P036 THE ROLE OF STAT1 ISOFORMS IN INFLAMMATION AND INTESTINAL ANTIBACTERIAL IMMUNITY / A. Puga*, M. Parrini, K. Meissl, C. Lassnig, T. Decker, M. Müller, B. Strobl (Austria)

P037 A NEW RNA-BASED ADJUVANT ENHANCES VIRUS-SPECIFIC VACCINE RESPONSES BY LOCALLY ACTIVATING DC AND INDUCING TYPE I IFN RESPONSES TLR- AND RLH-DEPENDENTLY / A. Ziegler*, C. Soldner, S. Lienenklaus, J. Spanier, T. Kramps, E. Jasny, K.-J. Kallen, R. Heidenreich, M. Fotin-Mleczek, U. Kalinke (Germany)

P038 DECIPHERING THE ROLE OF PROTEIN PHOSPHORYLATION IN CEREBRAL TYPE I INTERFERONOPATHIES / B. Viengkhou*, M. Y. White, I. L. Campbell, S. J. Cordwell, M. J. Hofer (Australia)

P039 TRANSCRIPTOME ANALYSIS OF DIFFERENTIALLY EXPRESSED ISG SUBSETS IN ACUTE AND CHRONIC PHASE OF PATHOGENIC SIV INFECTION IN MACAQUES SUGGESTS BOTH TYPE I AND TYPE II INTERFERONS CONTRIBUTE TO PERSISTENT ISG EXPRESSION / N. Echebli, N. Tchitchek, S. Dupuy, T. Bruel, R. Le Grand, B. Vaslin* (France)

P040 DIFFERENTIAL PRODUCTION OF TYPE I IFN DETERMINES THE RECIPROCAL LEVELS OF IL-10 AND PROINFLAMMATORY CYTOKINES PRODUCED BY C57BL/6 AND BALB/C MACROPHAGES / C. Taubert*, A. Howes, S. Blankley, N. Spink, X. Wu, C. M. Graham, G. J. Bancroft, A. O’Garra (UK)

P041 THE AUTOPHAGY-RELATED KINASE ULK1 IS REQUIRED FOR INTERFERON GAMMA SIGNAL TRANSDUCTION AND ANTIVIRAL RESPONSES / D. Saleiro*, G. T. Blyth, E. M. Kosciuczuk, A. D. Arslan, M. Fischietti, B. Majchrzak-Kita, E. N. Fish, L. C. Platanias (USA)

P042 POTENTIAL ROLE OF ORAL BACTERIA IN DEREGULATION OF HUMAN SALIVARY GLANDULAR EPITHELIAL CELLS / D. I. Kwon*, J. Alam, J. Alam, S. K. Kwok, S. K. Kwok, S. H. Park, S. H. Park, H. K. Park, H. K. Park, Y. Choi, Y. Choi (Republic of Korea)

P043 MACROPHAGE EXPRESSION OF AN IFNGR1 THAT RESISTS DOWN REGULATION INCREASES RESISTANCE TO BACTERIAL INFECTIONS / E. M. Eshleman*, S. J. Kearney, L. L. Lenz (USA)

P045 DNA DAMAGE ACTIVATES CGAS-STING INNATE IMMUNE RESPONSE / G. Pepin*, J. Ferrand, C. Nejad, K. Höning, V. Hornung, M. Gantier (Australia)

P046 DEVELOPMENT OF A NOVEL ASSAY FOR ULTRASENSITIVE MEASUREMENT OF SERUM INTERFERON GAMMA / S. E. Wheeler, J. M. Suschak, A. Aghvanyan, G. Tiwari*, A. Mathew, M. Stengelin, E. N. Glezer, J. N. Wohlstadter (USA)

P047 THE SEX BIAS OBSERVED IN A MURINE MODEL OF LIVER AUTOIMMUNITY INVOLVES CD4+ T CELLS AND THE INTERPLAY OF TYPE I AND TYPE II INTERFERONS / H. Young*, P. Leung, K. Tsuneyama, J. Valencia, D. Hodge, S. Kim, T. Back, M. Karwan, A. Merchant, N. Baba, D. Feng, O. Park, B. Gao, G.-X. Yang, M. E. Gershwin, H. Bae (USA)

P048 THE SUPERIORITY OF IFN-LAMBDA AS A THERAPEUTIC CANDIDATE TO CONTROL ACUTE INFLUENZA VIRAL LUNG INFECTION / H. J. Kim*, S. W. Cho, P. Park (Republic of Korea)

P049 EVOLUTIONARY ADAPTATIONS SUPPRESS INTERFERON LAMBDA 4 EXPRESSION DURING VIRAL INFECTION / J. Schwerk*, M. Hong, C. Lim, A. Kell, A. Jarret, J. Pangallo, Y.-M. Loo, M. Gale Jr, R. Savan (USA)

P050 THE KINETICS OF TYPE I INTERFERON RESPONSES REGULATE INDUCTION OF ADAPTIVE IMMUNITY AND ANTIVIRAL MEMORY / J. Spanier*, T. Adomati, P. K. Tegtmeyer, K. S. Lang, P. Staeheli, U. Kalinke (Germany)

P051 THERAPEUTIC ELIMINATION OF THE TYPE 1 INTERFERON RECEPTOR FOR TREATING PSORIATIC SKIN INFLAMMATION / J. Gui*, M. Gober, X. Yang, K. V. Katlinski, C. M. Marshall, M. Sharma, V. P. Werth, D. P. Baker, H. Rui, S. Y. Fuchs (USA)

P052 DIFFERENT ANTIVIRAL EFFECTS OF IFN-ΑLPHA SUBTYPES IN A MOUSE MODEL OF HBV INFECTION / K. Gibbert*, J. Song, U. Dittmer (Germany)


P053 USING IFN PRODUCTION TESTS, CLINICAL AND PSYCHOLOGICAL INDICATORS TO PROVIDE INDIVIDUALIZED SUPPORT FOR EVACUEES LIVING IN TEMPORARY HOUSING IN MINAMI-SOMA AND SOMA CITY (FUKUSHIMA) / K. Uno*, Y. Shimada, M. Tsubokura, A. Ozaki, K. Hashino, K. Yamamoto, S. Ochi, T. Mori, M. Takagaki, K. Yagi, Y. Kanazawa, T. Oikawa (Japan)

P054 TYPE I INTERFERON-INDUCED PD-L1 AND IL-10 SUPPRESS TH1 PRIMING DURING PERSISTENT VIRAL INFECTION / L. M. Snell*, I. Osokine, D. H. Yamada, H. J. Elsaesser, D. G. Brooks (Canada)

P055 CK2 MEDIATES MACROPHAGE SUPPRESSION BY TYPE I IFNS AND IS A TARGET FOR HOST-DIRECTED THERAPY OF BACTERIAL INFECTIONS / L. L. Lenz*, C. Delgado, E. M. Eshleman, K. Haist, T. Morrison (USA)

P056 CELLULAR FLICE INHIBITORY PROTEIN (CFLIP) MODULATES INTERFERON REGULATORY FACTORS 3 AND 7 BY TWO INDEPENDENT MECHANISMS / L. Gates*, J. Shisler (USA)

Innate and adaptive immune mechanisms of host defense I

P057 INHIBITION OF DENDRITIC CELLS IL-12 PRODUCTION BY PARACOCCIDIOIDES BRASILIENSIS IS NOT MEDIATED BY MINCLE ENGAGEMENT / A. Tavares*, G. S. Silva, D. A. Silva (Brazil)

P058 NLRP3 INFLAMMASOME CONTRIBUTION TO HOST PROTECTION DURING INFECTION BY SPOROTHRIX SCHENCKII / A. C. Gonçalves*, L. S. Ferreira, F. A. Manente, J. A. Jellmayer, C. M. Q. G. de Faria, M. C. Polesi, D. S. Zamboni, I. Z. Carlos (Brazil)

P059 ORCHESTRATION OF NUCLEIC ACID SENSING PATHWAYS IN HSV-SPECIFIC CD8+ T CELL PRIMING / A. Bachem*, P. G. Whitney, M. Greyer, C. Tebartz, T. Gebhardt, S. Bedoui (Australia)

P060 REGULATION OF MACROPHAGE INFLAMMATORY RESPONSE BY CELL STRESS DEPENDS UPON POLARIZATION STATE / C. Zhao*, S. Datta, P. Pavicic, T. Hamilton (USA)

P061 CONNECTING DIFFERENTIAL OUTCOMES TO WNV INFECTION IN COLLABORATIVE CROSS MOUSE MICE TO ASSOCIATED TRANSCRIPTIONAL PROFILES / C. Wilkins*, R. Green, S. Thomas, A. Sekine, K. Voss, D. Hendrick, R. Ireton, M. Mooney, G. Choonoo, M. T. Ferris, S. McWeeney, J. Lund, J. D. Beckham, M. Gale, Jr. (USA)

P062 POSITIVE REGULATION OF INNATE IMMUNE SIGNALING BY E3 UBIQUITIN LIGASE TRIM65 / D. Fonseca*, A. Garcia-Sastre (USA)

P063 CELLULAR DETECTION OF MEMBRANE FUSION MODULATES THE IFN-I RESPONSE TO ENVELOPED VIRUS / D. Hare*, S. Collins, S. Mukherjee, L. Janssen, K. Mossman (Canada)

P064 HBV TRIGGERS A RAPID INTRINSIC INNATE CYTOKINE RESPONSE IN HEPATOCYTES THROUGH NF-KAPPA B / M. Yoneda, J. Hyun, E. Thomas* (USA)

P065 GALECTIN 3 FACILITATES RECRUITMENT OF THE GUANYLATE BINDING PROTEINS TO THE PATHOGEN CONTAINING VACUOLE / E. M. Feeley*, D. Pilla-Moffett, A. Piro, R. Finethy, J. Coers (USA)

P066 ASSESSMENT OF THE ANTIVIRAL ACTIVITY OF MXA AGAINST INFLUENZA A VIRUS / F. Steiner*, P. Nigg, L. Murer, M. Crameri, E. Moritz, J. Pavlovic (Switzerland)

P067 ASSESSMENT OF IMIQUIMODE, ALONE OR IN ASSOCIATION WITH ITRACONAZOL, AS AN ALTERNATIVE FOR SPOROTRICHOSIS THERAPY / F. A. Manente*, L. S. Ferreira, C. Quinello, C. M. Q. G. de Faria, A. C. Gonçalves, M. L. Loesh, J. A. Jellmayer, A. Batista-Duharte, I. Z. Carlos (Brazil)

P070 DETECTION OF FG/ML LEVELS OF GM-CSF IN HUMAN SERUM AND PLASMA / D. M. Lockney, J. M. Suschak, M. Stengelin, S. Ranganathan, G. Tiwari*, I. Davydov, E. N. Glezer, J. N. Wohlstadter (USA)

P071 REGULATION OF IMMUNE RESPONSES BY IL-27-PRODUCING CD4+ T CELLS INDUCED DURING MALARIA INFECTION / H. Yoshida*, D. Kimura, H. Hara, K. Yui (Japan)

P072 IRAP-CONTAINING ENDOSOMES REGULATE TLR9 TRAFFICKING AND ACTIVATION / J. Babdor*, L. Saveanu (France)

P073 HDAC6 REGULATES CELLULAR VIRAL RNA SENSING BY DEACETYLATION OF RIG-I / J.-S. Lee* (Republic of Korea)

P074 PHOSPHORYLATION-DEPENDENT FEEDBACK-INHIBITION OF RIG-I BY THE DEATH ASSOCIATED PROTEIN KINASE 1 IDENTIFIED BY KINOME-WIDE SIRNA SCREENING / J. Willemsen*, O. Wicht, J. Wolanski, N. Baur, S. Bastian, D. Haas, P. Matula, B. Knapp, L. Meyniel-Schicklin, C. Wang, R. Bartenschlager, V. Lotteau, K. Rohr, H. Erfle, L. Kaderali, J. Marcotrigiano, A. Pichlmair, M. Binder (Germany)

P075 TRIM29 CONTROLS INNATE IMMUNITY IN THE RESPIRATORY TRACT / J. Xing*, Z. Zhang, Y.-J. Liu (USA)

P076 ELUCIDATING THE DIFFERENTIAL INDUCTION OF TYPE I INTERFERON FOLLOWING CLASS A SCAVENGER RECEPTOR UPTAKE OF EXTRACELLULAR RNA AND DNA / K. Mossman*, S. Nellimarla, K. Baid (Canada)


P077 REGULATION OF INHIBITOR OF APOPTOSIS (IAP) PROTEINS BY TOLL-LIKE RECEPTORS AND TYPE I INTERFERONS / K. Lawlor*, R. Feltham, J. Vince (Australia)

P078 DEFINING THE MITOCHONDRIA-ASSOCIATED MEMBRANE (MAM) AS THE RIG-I-LIKE RECEPTOR SIGNALING PLATFORM / K. Esser-Nobis*, S. Thomas, A. Sekine, K. Voss, D. Hendrick, R. Ireton, A. Stone, M. Gale, Jr. (USA)

Emerging cytokine-based therapies

P079 HETERODIMERIC IL-15 ENHANCES TUMOR INFILTRATION, PERSISTENCE AND EFFECTOR FUNCTIONS OF ADOPTIVELY TRANSFERRED TUMOR-SPECIFIC T CELLS IN THE ABSENCE OF LYMPHODEPLETION / C. Bergamaschi*, S. S. M. Ng, B. A. Nagy, S. M. Jensen, X. Hu, C. Alicea, B. A. Fox, B. K. Felber, G. N. Pavlakis (USA)

P080 NOVEL ANTI-IL-2 ANTIBODIES TO TARGET REGULATORY T CELLS AND PROMOTE IMMUNE TOLERANCE / E. Trotta*, N. Crellin, P. Bessette, S. Silveria, L. Ely, I. Rondon, J. Bluestone (USA)

P081 DEVELOPMENT AND VALIDATION OF THE THERAPEUTIC POTENTIAL OF A NOVEL IL-33 CYTOKINE TRAP IN A MOUSE MODEL OF ASTHMA / I. Afonina*, H. Braun, E. Van Nuffel, J. Haustraete, S. Detry, S. Savvides, M. Schuijs, H. Hammad, B. Lambrecht, R. Beyaert (Belgium)

P082 ROLE OF IFN-LAMBDA IN THE PATHOGENESIS OF HETEROLOGOUS ROTAVIRUS INFECTION IN SUCKLING MICE / J.-D. Lin*, J. Peng, C. McElrath, H.-C. Tseng, N. Feng, A. Sen, R. K. Durbin, J. E. Durbin, H. B. Greenberg, S. V. Kotenko (USA)

P083 OPTIMIZATION OF IL-15-BASED IMMUNOTHERAPY USING AN ORIGINAL IL-15 AGONIST / M. Frutoso*, S. Morisseau, D. Meghnem, S. Khaddage, Y. Jacques, E. Mortier (France)

P084 BNZ132-1-40: A DUAL INHIBITOR OF IL-2 AND IL-15 WITH AN ADVANTAGEOUS IN VIVO PROFILE AND SUPERIOR SPECIFICITY AS COMPARED TO A SMALL-MOLECULE JAK INHIBITOR / N. Doerr*, A. Basheer, L. Q. Al-Mawsawi, N. Azimi, Y. Tagaya (USA)

P085 POTENTIAL THERAPEUTIC EFFICACY OF A NOVEL SITE-SPECIFIC PEGYLATED INTERFERON ΒETA IN CHRONIC HEPATITIS B VIRAL INFECTION / R. Shimozono*, M. Tsuge, T. Iwamura, H. Narumi, T. Suzuki, M. Kainoh, T. Taniguchi, K. Chayama (Japan)

P086 TARGETING ATTENUATED CYTOKINES TO TUMOR CELLS RESULTS IN ENHANCED TUMOR KILLING WITH REDUCED OFF-TARGET ACTIVITY: ANTI-CD38-ATTENUKINE™ CASE STUDY / S. Pogue*, T. Taura, M. Bi, Y. Yun, A. Sho, M. Armanini, M. Fatholahi, M. Valencia, G. Mikesell, D. S. Wilson (USA)

P087 A NOVEL STRATEGY TO SPECIFICALLY BLOCK THE COOPERATION OF IL-15 AND IL-21 USING THE PEPTIDE-ANTAGONIST BNZ132-2 FOR THE TREATMENT OF CELIAC DISEASE / Y. Tagaya*, X. Wu, L. Q. Al-Mawsawi, N. Azimi, C. Ciszewski, B. Jabri (USA)

P087-b THE ROLES OF CONTINUOUS RENAL REPLACEMENT THERAPY IN ABDOMINAL SEPTIC SHOCK / T. Ueno*, T. Ikeda, M. M. McGrath, A. Chandraker (Japan)

T-cell subsets and cytokines

P088 IDENTIFICATION OF IL-17A-PRODUCING CELLS IN WHOLE BLOOD AND EFFECTS OF RORGT MODULATORS / A. R. De Leon-Tabaldo*, X. Xue, P. Soroosh, A. Fourie (USA)

P089 CHEMOKINE RECEPTOR RESOLUTION AND EFFECTS OF INCUBATION TEMPERATURE AS MEASURED BY STAIN INDEX USING MULTI-COLOR FLOW CYTOMETRY / A. Jackson*, R. Hingorani, S. Williams (USA)

P090 INTEGRATED OMICS APPROACH REVEALS NOVEL IL-23 TARGETS IN TH17 CELLS / G. Ryzhakov*, F. Powrie, R. Fischer, N. Ilott, B. Kessler (UK)

P091 MODULATION OF RETROVIRUS-SPECIFIC CD8+ T CELL RESPONSES BY IFN-ALPHA SUBTYPES / J. Dickow*, K. Gibbert, U. Dittmer (Germany)

P092 THE TRANSCRIPTION FACTOR HIF1Α CONTROLS EXPRESSION OF THE CYTOKINE IL-22 IN CD4 T CELLS / S. A. Budda, A. Girton, L. A. Zenewicz* (USA)

P093 GLYCOSYLATION-DEPENDENT MODULATION OF THE LL-2 SIGNALING AXIS DETERMINES TH17 DIFFERENTIATION AND IL-10 PRODUCTION / L. Gabrysova*, E. H. Mann, C. Whicher, L. Bradley, J. I. MacRae, C. M. Hawrylowicz, D. Anastasiou, A. O’Garra (UK)

P094 CONTRIBUTION OF FETAL IFN-G PRODUCING T CELLS IN THE BREAKDOWN OF MATERNAL-FETAL TOLERANCE / M. Frascoli*, L. Coniglio, P. W. Moradi, T. MacKenzie (USA)

P095 MSX2-INTERACTING NUCLEAR TARGET PROTEIN (MINT) IS A NOVEL REGULATOR OF TH9 DIFFERENTIATION / M. Ren*, W. Liao, M. Zheng, G. Peltz, W. J. Leonard (USA)


P096 INCREASED IL-35 PRODUCING T REGS AND CD19+IL-35+ CELLS ARE ASSOCIATED WITH DISEASE PROGRESSION IN LEPROSY PATIENTS / M. Tarique*, H. Naz, D. N. Rao (India)

P097 THE ACTIVATION OF HUMAN BLOOD AND GUT MAIT CELLS BY CYTOKINE AND/OR TCR TRIGGERING / T. Leng*, C. Willberg, P. Klenerman (UK)

P098 CRTAM IS REGULATED BY IL-6 AND IL-27 IN INFLAMMATORY ARTHRITIS / X. Liu*, A. Derrac Soria, A. Cardus Figueras, J. P. Twohig, R. Andrews, G. W. Jones, S. A. Jones (UK)

P098-b CRITICAL ROLES OF MTORC1 AND MTORC2 SIGNALING AND ANABOLIC METABOLISM IN FOLLICULAR HELPER T CELL DIFFERENTIATION / H. Zeng*, S. Cohen, J. Rathmell, H. Chi (USA)

P098-c IDENTIFICATION OF NOVEL IL-17-PRODUCING T CELL POPULATIONS, GAMMADELTA TCR-CD4-CD8- CELLS, IN TCR DELTA GENE-DEFICIENT MICE / A. Akitsu*, Y. Iwakura (Japan)

Inflammation and autoimmunity I

P099 PRODUCTS FROM THE PARASITIC NEMATODE ASCARIS SUUM SUPPRESS TLR4-DRIVEN INFLAMMATORY RESPONSES AND CYTOKINE SECRETION IN HUMAN DENDRITIC CELLS / H. E. Midttun, S. Almeida, P. Nejsum, A. Williams* (Denmark)

P100 IL-3 MAINTAINS IMMUNE TOLERANCE BY PROMOTING TREGS AND INHIBITING TH17 CELLS / A. Kumar*, S. T. Mhaske, L. Rani, G. C. Mishra, M. R. Wani (India)

P101 THE MECHANISM OF PATHOGENICITY OF IL-17 IN CNS AUTOIMMUNITY / A. McGinley*, K. Mills (Ireland)

P102 THE TRANSCRIPTION FACTOR IRF5 REGULATES HUMAN PLASMABLAST DIFFERENTIATION / S. De, B. Zhang, B. Ciccarelli, S. Singh, A. Winkler, R. Donnelly, B. Barnes* (USA)

P103 A LINK BETWEEN IRF5 GENOTYPE AND ONSET OF SYSTEMIC LUPUS ERYTHEMATOSUS / D. Li*, B. Barnes (USA)

P104 IN SITU DETECTION OF IDO1 AND IL-6 IN PANCREATIC ISLETS FROM DIABETIC SUBJECTS / F. A. Anquetil*, G. Mondanelli, T. Rodriguez Calvo, N. Gonzalez, M. G. von Herrath (USA)

P105 SELECTIVE INHIBITION OF NF-KAPPAB INDUCING KINASE (NIK) REDUCES DISEASE AND INFLAMMATION IN IFNΑ-ACCELERATED LUPUS NEPHRITIS DISEASE PRONE MICE / H. D. Brightbill*, N. Ramamoorthi, E. Suto, S. Sujatha-Bhaskar, E. Gogol, B. Jackson, L. Christian, S. Haller, C. Everett, P. Bir Kohli, J. Lesch, N. Blaquiere, K. Barrett, C. Austin, M. Townsend, M. H. A. Ismaili, J. DeVoss, A. Johnson, J. Hackney, W. Lee, B. McKenzie, S. Staben, J. Crawford, L. C. Wu, N. Ghilardi (USA)

P106 THE ROLE OF THE INNATE IMMUNE RESPONSE REGULATORY GENE ABCF1 IN MAMMALIAN EMBRYOGENESIS AND DEVELOPMENT / H. Arora*, S. M. Wilcox, L. Munro, F. Fenninger, L. Johnson, C. Pfeifer, P. Hoodless, W. Jefferies (Canada)

P107 ABIN1 INHIBITS IL-17R SIGNALING IN AN A20-INDEPENDENT MANNER / J. A. Cruz*, M. R. Simpson-Abelson, A. Garg , N. Amatya , A. Ma , R. Beyaert , B. Aneskievich , S. Gaffen (USA)

P108 CUTANEOUS OVEREXPRESSION OF ONCOSTATIN M LEADS TO ROBUST INFLAMMATION BUT ITS EXPRESSION IS NOT NECESSARY TO INDUCE A PSORIASIS-LIKE INFLAMMATION BY TOPICAL APPLICATION OF IMIQUIMOD ON MOUSE SKIN / M. Pohin, I. Petit-Paris, L. Favot, F. Blanchard, C. D. Richards, F.-X. Bernard, F. Morel, J.-C. Lecron*, J.-F. Jégou (France)

P109 CCDC134 AMELIORATES EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS BY SUPPRESSING TH1 AND TH17 CELLS / J. Huang*, P. Xia, X. Gong, L. Xiao, B. Yu, X. Qiu (China)

P109-b DEATH-ASSOCIATED PROTEIN KINASE NEGATIVELY REGULATES TH17 DIFFERENTIATION AND EAE DEVELOPMENT IN MOUSE / T.-F. Chou*, W.-C. Hsieh, Y.-T. Chuang, M.-Z. Lai (Taiwan)

P109-c DETECTION OF LOW ABUNDANCE CYTOKINES ASSOCIATED WITH INFLAMMATION IN HUMAN SERUM AND PLASMA WITH SWORD ELISA BOOSTER / M. Dobbs*, J. Altenburg, J. Gibson, K. Pullen, O. Hines, S. Tarrant, R. Donoho (USA)

Allergy

P110 EFFECTS OF S100A8 ON DIFFERENTIATION AND MIGRATION OF EOSINOPHILS / A.-Y. Gu*, D.-H. KIM, S.-Y. KIM, N.-R. Lee, M.-A. Lim, J.-S. Lee, I. S. KIM (Republic of Korea)

P111 S100A8 INHIBITS NEUTROPHIL APOPTOSIS BY CYTOKINE RELEASE VIA TLR4 IN BRONCHIAL EPITHELIAL CELLS / D.-H. Kim*, A.-Y. Gu, S.-Y. Kim, N.-R. Lee, M.-A. Lim, J.-S. Lee, I. S. Kim (Republic of Korea)

P112 HOUSE DUST MITE ALLERGEN SUPPRESSES NEUTROPHIL APOPTOSIS BY CYTOKINE RELEASE VIA PAR2 IN NORMAL AND ALLERGIC LYMPHOCYTES / I. S. Kim*, N.-R. Lee, A.-Y. Gu, D.-H. Kim, S.-Y. Kim, J.-S. Lee (Republic of Korea)


P113 SEMAPHORIN 4A-DEPENDENT TREG CELL EXPANSION BY PLASMACYTOID DC CONFERS PROTECTION AGAINST SEVERE VIRAL BRONCHIOLITIS AND SUBSEQUENT ASTHMA / J. P. Lynch*, R. Werder, M. Rogers, K. Lane, Z. Loh, K. Diener, M. Colonna, C. Forstner, P. Dennis, J. Hayball, G. Hill, A. Haque, K. Spann, S. Mazzone, J. Upham, S. Phipps (Australia)

P114 AEROALLERGEN-INDUCED IL-33 PREDISPOSES TO RESPIRATORY VIRUS-INDUCED ASTHMA BY DAMPENING TYPE I AND III INTERFERON PRODUCTION / R. B. Werder*, J. Lynch, J. Simpson, Z. Loh, V. Zhang, K. Spann, P. Sly, S. Mazzone, J. Upham, S. Phipps (Australia)

P115 INTERACTION OF DER P 2 WITH TOLL-LIKE RECEPTOR 4 AND ITS EFFECT ON CYTOKINE SECRETION / S.-Y. Kim*, N.-R. Lee, M.-J. Kim, B.-S. Park, I.-S. Kim (Republic of Korea)

Tuesday, 18 October 2016 - 13:30 - 15:00, Poster area

Immune regulation of inflammation and cancer II

P116 APOPTOSIS-INDUCED TOLERANCE: ROLE OF THE NOVEL CYTOKINE IL-38 / J. Mora*, Y. Han, I. Wittig, M. Putyrski, A. Ernst, B. Brüne, A. Weigert (Germany)

P117 NON-APOPTOTIC FAS SIGNALING IN HUMAN RETROVIRAL NEUROINFLAMMATION / J. Van Weyenbergh*, S. M. Menezes, F. E. Leal, T. Dierckx, R. Khouri, G. Silva-Santos, S. V. Schnitman, G. Lopez, C. Alvarez, M. Talledo, E. Gotuzzo, A.-M. Vandamme, B. Galvao-Castro (Belgium)

P118 PROTEOLYSIS REGULATES INTERLEUKIN-11 SIGNALLING / J. Lokau*, G. H. Waetzig, S. Rose-John, C. Garbers (Germany)

P119 BRD4 SETS CHROMATIN LANDSCAPE TO REGULATE CYTOKINE TRANSCRIPTION AND INFLAMMATORY DISEASES / K. Ozato* (USA)

P120 BLOCKING PD-1 IMPROVES THE EFFICACY OF A CANCER VACCINE BY REDUCING TUMOUR-INFILTRATING TREG CELLS AND ENHANCING EFFECTOR T CELL RESPONSES IN A MURINE TUMOUR MODEL / L. Dyck*, M. M. Wilk, M. Raverdeau, A. Misiak, K. H. G. Mills (Ireland)

P121 STATTIC AND STX-0119 MEDIATED INHIBITION OF STAT AND IRF TARGET GENES AS A NOVEL TREATMENT STRATEGY OF CVDS / M. Plens-Galaska*, M. Szelag, A. Piaszyk-Borychowska, J. Wesoly, H. Bluyssen (Poland)

P122 NOD2 CONTRIBUTES TO HOST DEFENSE AGAINST PULMONARY INFECTION OF ACINETOBACTER BAUMNNAII / M.-J. Kang*, J.-Y. Lee, J.-H. Park (Republic of Korea)

P123 IL-6 PROMOTES MYC-INDUCED LYMPHOMAGENESIS INDEPENDENT OF STAT3 / N. Reich Marshall*, P. Mena-Taboada, V. Poli, A. Petrenko (USA)

P124 BASOPHIL-LINEAGE CELLS DRIVE THE LEUKEMIC HEMATOPOIESIS OF CHRONIC MYELOID LEUKEMIA IN MICE BY CONSTITIVE CCL3 EXPRESSION / N. Mukaida*, Y. Tanabe, T. Baba (Japan)

P125 CIRCULATING SOLUBLE INTERLEUKIN-6 RECEPTOR DRIVES CELL MIGRATION DURING ACUTE INFLAMMATION / N. Schumacher*, S. Schmidt, J. Schwarz, A. Chalaris, S. Rose-John, B. Rabe (Germany)

P129 SECRETION OF IL-1BETA FROM TKI-RESISTANT CELLS CONTRIBUTES TO BCR-ABL MUTATION-INDEPENDENT TKI RESISTANCE IN CHRONIC MYELOID LEUKEMIA / S.-G. Park*, C.-R. Lee, J.-A. Kang (Republic of Korea)

P130 SOCS-1 GENE THERAPY HAS ANTITUMOR EFFECTS BY THE INHIBITION OF JAK/STAT AND FAK/ERK SIGNALING IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA / T. Sugase*, T. Takahashi, S. Serada, R. Nakatsuka, M. Fujimoto, K. Tanaka, Y. Miyazaki, T. Makino, Y. Kurokawa, M. Yamasaki, K. Nakajima, S. Takiguchi, M. Mori, Y. Doki, T. Naka (Japan)

P131 FUNCTIONAL DISORDERS AND ACTIVATING JAK/STAT MUTATIONS IN T-CELL LEUKEMIA/LYMPHOMA / J. Chen, T. Waldmann* (USA)

P132 PGE2 IS A KEY FACTOR FOR THE ACTIVATION OF THE COMPLEX TRANSCRIPTIONAL PROGRAM REQUIRED FOR TLR-INDUCED VEGF-A EXPRESSION IN HUMAN DENDRITIC CELLS / V. Salvi*, W. Vermi, V. Gianello, S. Lonardi, S. Sozzani, D. Bosisio (Italy)

P133 THE INFLAMMASOME ADAPTOR ASC PROMOTES TUMOUR CELL SURVIVAL, INDEPENDENT OF INFLAMMATION, IN GASTRIC CANCER VIA IL-18 / V. Deswaerte*, P. Nguyen, T. Putoczki, B. Jenkins (Australia)

P134 UP-REGULATION OF FSP-1 IN FIBROBLASTS CULTURED WITH BREAST CANCER CELLS AND ITS IMPACT ON BREAST CANCER GROWTH / W. L. Li, L. X. Xiong, H. Liu, X. Y. Shi* (China)


Interferons: regulators of immunity and inflammation II

P135 STAT1 IS A CRITICAL REGULATOR OF INTESTINAL VIRAL INFECTION AND VIRUS-INDUCED DISEASE / L. C. Osborne*, H. A. Filyk, D. Artis (Canada)

P136 TYPE I IFN INHIBITS ALTERNATIVE MACROPHAGE ACTIVATION DURING MYCOBACTERIUM TUBERCULOSIS INFECTION AND LEADS TO ENHANCED PROTECTION IN THE ABSENCE OF IFN-G SIGNALING / L. Moreira-Teixeira*, J. Sousa, F. W. McNab, E. Torrado, F. Cardoso, H. Machado, F. Castro, V. Cardoso, J. Gaifem, X. Wu, R. Appelberg, A. G. Castro, A. O’Garra, M. Saraiva (Portugal)

P137 IFN-LAMBDA PRODUCTION IS MEDIATED BY EPITHELIAL CELLS IN THE SMALL INTESTINE AND CD8ALPHA DENDRITIC CELLS IN THE SPLEEN IN VIVO / M. J. Sandoval*, J.-D. Lin, Q. Li, H.-C. Tseng, H. Risman, R. K. Durbin, S. V. Kotenko, J. E. Durbin (USA)

P138 DISSECTING THE ROLE OF THE TYPE I INTERFERON RECEPTORS IN MODULATING INFLAMMATION IN VIVO / M. D. Tate*, J. K. Dowling, N. A. De Weerd, P. J. Hertzog (Australia)

P139 PRIMARY HUMAN PDC FUNCTION IS AFFECTED BY IFNL SINGLE NUCLEOTIDE POLYMORPHISMS INDEPENDENT OF IFNL4 PROTEIN ACTIVITY / M. Nooruzzaman*, E. Grabski, T. Pietschmann, R. Hartmann, U. Kalinke (Germany)

P140 UNDERSTANDING THE IFNΒ-IFNAR1 INTERFACE: IMPLICATIONS FOR DRUG DISCOVERY IN IFNΒ-DRIVEN DISEASE / N. A. De Weerd*, A. Matthews, S. S. Lim, P. Pattie, N. Bourke, J. P. Vivian, J. Rossjohn, P. J. Hertzog (Australia)

P141 ACCESS OF PROTECTIVE ANTIVIRAL ANTIBODY TO NEURONAL TISSUES REQUIRES CD4 T-CELL HELP / N. Iijima*, A. Iwasaki (USA)

P142 HUMAN PLASMACYTOID DENDRITIC CELLS PRODUCE TYPE-I AND TYPE-III INTERFERONS VIA THE CGAS-STING PATHWAY / P. Deb*, J. Dai, S. Singh, P. Fitzgerald-Bocarsly (USA)

P143 OPPOSING ROLES OF AIM2 INFLAMMASOME AND TYPE I INTERFERON SIGNALING IN FRANCISELLA INFECTION / Q. Zhu*, S. M. Man, R. Karki, T.-D. Kanneganti (USA)

P144 GENERATION AND CHARACTERIZATION OF INTERFERON-LAMBDA 1-RESISTANT H1N1 INFLUENZA A VIRUSES / N. A. Ilyushina, F. Sheikh, N. V. Bovin, R. P. Donnelly* (USA)

P145 IMMUNITY RELATED GTPASES CONTROL CASPASE-11 ACTIVITY TO PROTECT AGAINST SEPTIC SHOCK / R. Finethy*, A. Piro, A. Haldar, G. Taylor, J. Coers (USA)

P146 INTERFERON LAMBDA-4 IS A MEMBER OF IFN-LAMBDA FAMILY WITH DISTINCT PROPERTIES / S. Singh*, R. Sridhar, C. McElrath, S. Smirnov, J. Langer, R. Durbin, J. Durbin, S. V. Kotenko (USA)

P147 INTERFERON LAMBDA IS A MEDIATOR OF INFLAMMATION THROUGH MACROPHAGE ACTIVATION / S. Read*, M. Ramezani-Moghadam, E. Tay, C. Liddle, M. Douglas, D. Booth, J. George, G. Ahlenstiel (Australia)

P148 FUNCTIONAL INTERPLAY BETWEEN TYPE I AND II INTERFERONS IS ESSENTIAL TO LIMIT INFLUENZA A VIRUS-INDUCED TISSUE INFLAMMATION / S. Stifter*, N. Bhattacharyya, C. Feng (Australia)

P149 SRC FAMILY KINASE MEMBERS MEDIATE TYPE I INTERFERON PRODUCTION BY PLASMACYTOID DENDRITIC CELLS / S. Dallari*, M. Macal, M. E. Loureiro, Y. Jo, C. Hesser, E. Zuniga (USA)

P150 IFIT1 REGULATES PROINFLAMMATORY AND ANTIVIRAL GENE PROGRAMS IN LPS-STIMULATED MACROPHAGES / S. P. John*, J. Sun, I. Fraser (USA)

P151 MOVE OVER RETROVIRUSES: TRIM5 IS A POTENT RESTRICTION FACTOR FOR TICK-BORNE FLAVIVIRUSES / A. Chiramel, N. Meyerson, V. Montoya, K. McNally, S. Robertson, G. Sturdevant, T. Taylor, S. Sawyer, S. Best* (USA)

P152 SEX-SPECIFIC DIFFERENCES IN TYPE I INTERFERON SUBTYPES AND INTERFERON Α/Β RECEPTOR EXPRESSION ON HUMAN PLASMACYTOID DENDRITIC CELLS / S. Ziegler*, C. Beisel, K. Gibbert, M. Griesbeck, H. Hildebrandt, S. Hagen, U. Dittmer, M. Altfeld (Germany)

P153 HIGHLY PATHOGENIC AVIAN INFLUENZA VIRUS RESTRICTS INTERFERON GAMMA RESPONSES IN MACROPHAGES IN A REPLICATION-DEPENDENT MANNER / T. Cline*, K. Sekar, D. Beck (USA)

P154 STING REQUIRES TRIF TO TRIGGER INTERFERON SYNTHESIS / X. Wang*, G. Sen (USA)

P155 TYPE 1 INTERFERON IS CRITICAL TO CONTROL VIRUS INFECTION AND REGULATE INFLAMMATION RESPONSE DURING COXSACKIE B3 VIRUS INFECTION IN MICE / Y. Xiao*, R. Andino (USA)

P156 NEGATIVE REGULATION OF TYPE I IFN SIGNALING BY PHOSPHORYLATION OF STAT2 ON T387 / Y. Wang*, J. Nan, B. Willard, G. R. Stark (USA)

P156-b CYCLIC GMP/AMP SYNTHASE SENSES HUMAN CYTOMEGALOVIRUS AND INDUCES TYPE I INTERFERON RESPONSES IN HUMAN MONOCYTE-DERIVED CELLS / J. Paijo*, M. Döring, J. Spanier, E. Grabski, M. Nooruzzaman, T. Schmidt, G. Witte, M. Messerle, V. Hornung, V. Kaever, U. Kalinke (Germany)


P156-c MODULATION OF INTERFERON-GAMMA RECEPTOR IN MACROPHAGES BY MYCOBACTERIUM TUBERCULOSIS / G. Kak*, B. Tiwari, K. Natarajan (India)

P156-d THE OPTIMIZATION OF THE RSAD2 SIRNA CONCENTRATION IN HUH-7 CELLS TREATED WITH INTERFERON ALPHA / P. Shirmast*, H. Mirshahabi, E. Arefian, F. Haghi (Iran)

P156-e ZVAD-INDUCED NECROPTOSIS IN TLR3/4-STIMULATED MACROPHAGES INVOLVES TRIF-DEPENDENT INTERFERON SIGNALING PATHWAY AND ROS-DEPENDENT AUTOPHAGY / W.-W. Lin* (Taiwan)

Innate and adaptive immune mechanisms of host defense II

P157 CYTOKINE RESEARCH IN DROSOPHILA - ENDOPLASMIC RETICULUM STRESS IS AN INITIATOR OF DROSOPHILA ANTIVIRAL DEFENSE / K. Onoguchi*, R. Andino (USA)

P158 EPITHELIAL IL-17R SIGNALING IS REQUIRED FOR MUCOSAL CHEMOKINE GRADIENTS AND PULMONARY HOST DEFENSE AGAINST K. PNEUMONIAE / K. Chen*, J. Kolls (USA)

P159 BRUTON’S TYROSINE KINASE PHOSPHORYLATES DDX41 AND ACTIVATES ITS BINDING OF DOUBLE-STRANDED DNA AND STING TO INITIATE TYPE 1 INTERFERON RESPONSE / K. G. Lee* (Singapore)

P160 IRF5 DIRECTLY REGULATE INNATE IMMUNE GENE EXPRESSION TO ORCHESTRATE ANTIVIRAL IMMUNITY / K. Chow*, C. Wilkins, R. Green, M. Gale, Jr. (USA)

P161 HUMAN HAQ STING DOES NOT RESPOND TO CYCLIC DINUCLEOTIDE IN VIVO AND IN VITRO / S. Patel, S. blaauboer, H. tucker, S. mansouri, J. S. Ruiz-Moreno, L. Hamann, R. R. Schumann, B. Opitz, L. Jin* (USA)

P162 T CELL DERIVED IL-10 IMPAIRS THE CONTROL OF MYCOBACTERIUM TUBERCULOSIS INFECTION / L. Moreira-Teixeira*, P. S. Redford, E. Stavropoulos, C. L. Maynard, C. T. Weaver , A. P. F. do Rosário, X. Wu, J. Langhorne, A. O’Garra (UK)

P163 LOCALIZATION OF PROTEIN COMPLEXES IN THE ACTIVATION OF THE RIG-I LIKE RECEPTOR PATHWAY / M. Sanchez-Aparicio*, J. Ayllon, A. Garcia-Sastre (USA)

P164 THE INTERFERON-INDUCED MXB PROTEIN IS A HERPES SIMPLEX VIRUS TYPE I RESTRICTION FACTOR / M. Crameri*, R. Walker, F. Franzoso, C. Fraefel, J. Pavlovic (Switzerland)

P165 FUNCTION OF TOLL-LIKE RECEPTOR 2 IN THE MURINE INFLAMMATORY RESPONSE TO RHODOCOCCUS AURANTIACUS INFECTION / M. Yi*, M. Kohanawa, S. Haga, M. Ozaki (Japan)

P166 NON-CANONICAL AND CELL TYPE-SPECIFIC FUNCTIONS OF TYK2 IN THE DEFENCE AGAINST LISTERIA MONOCYTOGENES / N. Bozovic*, C. Lassnig, S. Stockinger, K. Meissl, B. Strobl, M. Müller (Austria)

P167 MECHANISTIC ANALYSIS OF MCOLN2: AN ISG THAT ENHANCES VIRAL INFECTION / N. Rinkenberger*, J. Schoggins (USA)

P168 TRACKING DOWN CYTOKINE NETWORK IN GENETICALLY-DIVERSE MURINE POPULATION DURING RESPIRATORY INFECTION BY PSEUDOMONAS AERUGINOSA / N. I. Lorè*, B. Sipione, C. Brombin, R. Mott, F. A. Iraqi, A. Bragonzi (Italy)

P169 IDENTIFICATION AND CHARACTERIZATION OF ANTIVIRAL INTERFERON-STIMULATED GENES IN THE BAT PTEROPUS ALECTO / P. C. De La Cruz-Rivera*, C. Xing, M. Kanchwala, H. Liang, A. Kumar, J. Eitson, L. Wang, J. W. Schoggins (USA)

P170 DENDRITIC CELLS, DIVISION OF LABOR DURING PERIPHERAL HERPES SIMPLEX VIRUS-1 INFECTION / P. G. Whitney*, C. Tebartz, B. L. Macleod, A. Bachem, A. Turner, D. Tscharke, S. Bedoui (Australia)

P171 TARGETING THE HOST RESPONSE TO TREAT BACTERIAL INFECTIONS / R. D’elia*, T. Laws, S. Vautier, M. Travis, D. Williamson, G. Clark (UK)

P172 IDENTIFICATION OF A GONAD SPECIFIC NEGATIVE REGULATOR OF CYTOSOLIC NUCLEIC ACID SENSING / S. Shapira*, T. Abe, A. Lee, G. Lasso Cabrera, R. Sitharam, J. Kesner, B. Honig, R. Rabadan (USA)

P173 HUMAN PDCS UPTAKE AND KILL ASPERGILLUS FUMIGATUS SPORES, EXPRESS FUNCTIONAL CLR DECTIN-1, AND SHOW DIFFERENCES IN HIV-INFECTED SUBJECTS / S. Maldonado*, J. Dai, S. Singh, S. Swaminathan, A. Rivera, P. Fitzgerald-Bocarsly (USA)

P174 TWO PHENOTYPICALLY SUBSETS OF OX-62 DENDRITIC CELLS EXHIBITED TH1/TH2 CYTOKINES PROFILE ASSOCIATED WITH AGE-RELATED RESISTANCE OR SUSCEPTIBILITY OF PLASMODIUM BERGHEI INFECTION IN RAT / S. Dasse*, L. Siransy, N. Koffi, R. Yeboah, P. Kouacou, H. Adou, M. Sombo, K. Jamal (Côte d’Ivoire)

P175 TLR CONTROL OF INFLAMMATORY SIGNALING IN APAP-INDUCED HEPATIC INJURY / S. Datta*, C. Zhao, P. Pavicic Jr., G. Sen, T. Hamilton (USA)

P176 ROLE OF RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN 1 (G3BP1) IN IFN RESPONSE AND STRESS GRANULE FORMATION / S. S.-Y. Kim* (Singapore)

P177 INTERFERON-STIMULATED INNATE IMMUNE CONTROL OF PERSISTENT MURINE NOROVIRUS INFECTION / T. Nice*, H. W. Virgin (USA)


P178 EXPLOITING CONTRASTS IN VIRAL ANTAGONISM TO IDENTIFY HOST FACTORS DRIVING IMMUNITY TO INFECTION / V. D. Menachery*, L. E. Gralinski, A. Schäfer, J. F. Kocher, A. C. Sims, L. Thackray, A. Eisfeld, M. S. Diamond, Y. Kawaoka, R. S. Baric (USA)

P178-b BACTERIAL LECTIN ACTS AS POLYCLONAL B CELL ACTIVATOR / I. M. Wilhelm*, E. Hobeika, W. Römer on behalf of group of Jun.Prof. Winfried Römer, SGBM Graduate School of Biology and Medicine Freiburg (Germany)

P178-c DENGUE VIRUS ACTIVATE BOTH CANONICAL AND NON-CANONICAL INFLAMMASOME PATHWAY IN HUMAN MACROPHAGES / S.-L. E. Hsieh* (Taiwan)

P178-d PROVIRAL ROLES OF ADAR1 AND PACT IN HIV-1 INFECTION / R. Radetskyy*, A. Daher, S. Burugu, J.-P. Routy, A. Gatignol (Canada)

Cytokines and metabolic diseases

P179 EXCESS WEIGHT IN ADOLESCENTS IS ASSOCIATED WITH INCREASED LEVELS OF INFLAMMATORY CYTOKINES / C. S. Kurokawa*, T. B. L. Goldberg, V. Nobrega, L. T. L. Medeiros, I. R. Betti, G. R. LIma, G. G. Romagnoli, L. R. Oliveria, B. Gonçalvez, A. C. B. Rizzo (Brazil)

P180 SPECIFIC SIRT1 ACTIVATION IN POLARIZED MACROPHAGES IMPROVES INSULIN-DEPENDENT AKT PHOSPHORYLATION IN ADIPOCYTES IN VITRO / I. Stafeev*, A. Vorotnikov, V. Yunusova, M. Menshikov, Y. Parfyonova (Russia)

P181 CIGARETTE SMOKE EXPOSURE INCREASES LEVEL OF PRO-INFLAMMATORY CYTOKINES IN THE LUNG AND GUT TOGETHER / J. Kim*, D. Lim (Republic of Korea)

P182 PRMT1 MEDIATES RANKL-INDUCED OSTEOCLAST FORMATION AND ACTIVITY IN VITRO AND IN VIVO / J. H. Choi*, A.-R. Jang, J.-Y. Park, J.-H. Park (Republic of Korea)

P183 THE INTERLEUKIN-6-NEUTRALIZING SOLUBLE (S)IL-6R/SGP130 BUFFER SYSTEM IS DISTURBED IN PATIENTS WITH TYPE 2 DIABETES MELLITUS / S. Aparicio Siegmund*, Y. Garbers, C. M. Flynn, G. H. Waetzig, I. Gouni-Berthold, W. Krone, H. K. Berthold, S. Rose-John, C. Garbers (Germany)

P184 INFLAMMATORY BIOMARKER PROFILES ARE DYSREGUATED IN COMBAT VETERANS WITH PTSD VERSUS HEALTHY WARZONE DEPLOYED AND NON-DEPLOYED SOLDIERS / S. G. Rhind*, I. Boileau, R. Jetly, A. P. Di Battista, J. Tong, J. D. Richardson, R. A. Lanius (Canada)

P185 VASCULAR ENDOTHELIAL GROWTH FACTOR A REGULATES BLOOD CELL DEVELOPMENT THROUGH EHMT1 / X. Lu*, Y. Fang, Y. Zhang, Y. Zheng, Y. Tan (China)

P186 THE RESEARCH OF IL-13 EFFECT ON EGF EXPRESSION OF FIBROBLASTS CO-CULTURED WITH BREAST CANCER CELLS IN VITRO AND IN VIVO / X.-Y. Shi*, W.-L. Li, H. Lu, H. Liu (China)

Innate immunity at barrier surfaces

P187 IMPACT OF E. COLI NISSLE 1917, LACTOBACILLUS AMYLOVORUS AND SALMONELLA TYPHIMURIUM ON INTESTINAL IL-8, IL-12/23 P40, TNF ALPHA, CLAUDIN-1 AND OCCLUDIN IN GNOTOBIOTIC PIGLETS / A. Splichalova*, I. Splichal, V. Slavikova (Czech Republic)

P188 ROLE OF IFNS IN GASTRO-INTESTINAL MUCOSAL INFLAMMATION / C. Mcelrath*, J.-D. Lin, J. Peng, R. Sridhar, V. Espinosa, O. Dutta, H.-C. Tseng, H. Risman, M. Sandoval, M. Galan, J. Durbin, A. Rivera, S. Kotenko (USA)

P189 IL-17 DRIVES PSORIATIC INFLAMMATION VIA DISTINCT, TARGET CELL-SPECIFIC MECHANISMS / H. Ha*, H. Wang, E. Claudio, W. Tang, U. Siebenlist (USA)

P190 SALMONELLA TYPHIMURIUM RFAG MUTANT SHOWS REDUCED TRANSCRIPTION OF TOLL-LIKE RECEPTOR 4 IN INTESTINE OF GNOTOBIOTIC PIGLETS / I. Splichal*, A. Splichalova, V. Slavikova (Czech Republic)

P191 INDUCTION OF CD40-DEPENDENT INFLAMMATION IN RAG2-/- MICE CAUSES COMPLEX TEMPORAL CHANGES IN HOST GENOME EXPRESSION AND THE COLONIC MICROBIOME COMPOSITION / L. Chang*, K. Ngo, M. Sablad, Y. Chen, M. Hsieh, M. Hesse (USA)

P192 CELLULAR POLARITY AND TYPE III INTERFERONS ARE KEY REGULATORS OF ANTIVIRAL INNATE IMMUNITY IN HUMAN INTESTINAL EPITHELIAL CELLS / M. Stanifer*, K. Pervolaraki, A. Rippert, L. Renn, C. Odendall, T. Theisen, R. Rabin, J. Kagan, S. Boulant (Germany)

P193 IFNL4 INDUCES A FASTER BUT MORE TRANSIENT ANTIVIRAL RESPONSE COMPARED TO OTHER TYPE III INTERFERONS / O. O. Onabajo*, N. Rao, A. A. Obajemu, D. A. Kari, F. Sheikh, R. Donnelly, R. S. Shabman, L. Prokunina-Olsson (USA)

P194 IL-22 SIGNALING PROTECTS AGAINST EXPERIMENTAL NECROTIZING ENTEROCOLITIS / Z. Hodzic*, O. Olivia Parks, C. Ma, A. Bolock, J. K. Kolls, M. Good (USA)


P194-b CASPASE 8 DRIVES INTESTINAL DAMAGE AND EXECUTES ENDOTOXIC SHOCK / P. Mandal*, S. B. Berger, Y. Feng, J. D. Lyons, L. Roback, J. Bertin, P. J. Gough, C. M. Coopersmith, D. S. Shayakhmetov, E. S. Mocarski (USA)

P194-c CYTOKINES IN COLOSTRUM ACCORDING TO GESTATIONAL AGE AND FETAL GROWTH / L. T. Santiago, N. A. Freitas, J. D. Meira Junior, C. S. Kurokawa*, L. M. S. D. S. Rugolo (Brazil)

P194-d PARASITE INFECTION INDUCES AN INTERFERON RESPONSE AND FETAL-LIKE STATE IN INTESTINAL CRYPT EPITHELIUM / A. K. Savage*, Y. M. Nusse, A. K. M. Rosendahl Huber, O. D. Klein, R. M. Locksley (USA)

P194-e DUAL T CELL- AND B CELL-INTRINSIC DEFICIENCY IN HUMANS WITH BI-ALLELIC RLTPR MUTATIONS / Y. Wang*, C. S. Ma, Y. Ling, A. Bousfiha, Y. Camcioglu, S. Jacquot, L. Lorenzo, C. Picard, A. Puel, J. C. Bustamante, S. Boisson-Dupuis, M. Malissen, B. Malissen, L. Abel, A. Hovnanian, L. Notarangelo, S. G. Tangye, J.-L. Casanova, V. Beziat, E. Jouanguy (France)

Cytokines and orchestration of innate and adaptive immunity

P195 BRAZILIAN PROPOLIS MODULATES CYTOKINE PRODUCTION BY LPS-ACTIVATED HUMAN MONOCYTES / B. J. Conti*, K. B. Santiago, F. L. Conte, E. O. Cardoso, L. P. G. Oliveira, M. T. Cruz, J. M. Sforcin (Brazil)

P196 DAMPS/MYD88 AXIS IN THE MODULATION OF HOST INFLAMMATORY AND HEALING RESPONSES TO CLASSIC TITANIUM-BASED BIOMATERIALS IN VIVO / C. C. Biguetti*, E. V. Silveira, A. C. Araujo-Pires, A. P. F. Trombone, A. Letra, R. M. Silva, G. Garlet (Brazil)

P197 BATF3-DEPENDENT DENDRITIC CELLS ARE REQUIRED FOR THE CD4+ T CELL RESPONSE TO IMMUNIZATION AGAINST PARASITIC INFECTION / D. A. Christian*, G. H. Pritchard, A. A. Koshy, C. Hunter (USA)

P198 INVESTIGATING THE E3 UBIQUITIN LIGASE PELLINO2 FUNCTIONS IN INNATE AND ADAPTIVE IMMUNE RESPONSES / E. Oleszycka*, F. Humphries, B. Wang, P. N. Moynagh (Ireland)

P199 PROPOLIS ACTION IN CYTOKINE PRODUCTION BY RETINOIC ACID-STIMULATED HUMAN MONOCYTES / F. L. Conte*, K. B. Santiago, B. J. Conti, E. O. Cardoso, L. P. G. Oliveira, M. T. Cruz, J. M. Sforcin (Brazil)

P200 IL-10 EXPRESSING CD4+ T CELLS IN HERPESVIRUS PERSISTENCE WITHIN MUCOSAL TISSUE / I. Humphreys*, M. Clement, S. Clare, J. Abdul-Karim, M. Mardsen, M. Tomisawa (UK)

P201 FUNCTIONAL CHARACTERIZATION OF METEORIN-LIKE/IL-39, A NOVEL CYTOKINE PRODUCED BY MACROPHAGES AND BARRIER TISSUES / I. Ushach*, C. Schneider, M. B. Lodoen, A. Zlotnik (USA)

P202 THE ROLE OF CELL DEATH SIGNALING MOLECULES, AND THE ACT OF CELL DEATH ITSELF, IN IL-1BETA PROCESSING, ACTIVATION AND SECRETION / S. Conos, D. Vaux, K. Lawlor, L. Lindqvist, J. Vince* (Australia)

P203 MODIFICATION OF ACUTE INFLAMMATION AS A CONSEQUENCE OF RECURRENT INFLAMMATORY CHALLENGE / J. Uceda*, A. Cardus, C. M. Rice, R. Andrews, B. C. Cossins, J. P. Twohig, P. R. Taylor, N. M. Williams, G. W. Jones, S. Jones (UK)

P204 IMMUNOMODULATORY ACTION OF PROPOLIS ON MAGE-1-INDUCED CYTOKINE PRODUCTION BY HUMAN MONOCYTES / K. B. Santiago*, B. J. Conti, F. L. Conte, L. P. G. Oliveira, E. O. Cardoso, M. T. Cruz, J. M. Sforcin (Brazil)

P205 INTERFERON-STIMULATED GENE LY6E ENHANCES ENTRY OF DIVERSE RNA VIRUSES / K. B. Mar*, J. L. Eitson, J. W. Schoggins (USA)

P206 THE STING PATHWAY REGULATES PRODUCTION OF SOLUBLE IL-15 COMPLEXES / K. S. Schluns*, S. M. Anthony, S. C. Rivas (USA)

P207 MACROPHAGES ARE A CENTRAL HUB OF INNATE IMMUNITY AND INFLAMMATORY SIGNALING PROGRAMS INDUCED BY HCV INFECTION / L. D. Aarreberg*, A. A. Negash, M. Gale, Jr. (USA)

P209 ALTERATION OF THE MICROGLIA PHENOTYPE IN AN IL-6-DRIVEN CYTOKINOPATHY OF THE CENTRAL NERVOUS SYSTEM / P. K. West*, O. Butovsky, I. L. Campbell (Australia)

P210 IL-17A IS DISPENSABLE FOR AUTOIMMUNE TISSUE DAMAGE IN THE NEURORETINA AND NEGATIVELY REGULATES THE TH17 CYTOKINE PROGRAM / W. P. Chong, R. Horai, P. B. Silver, Y. Jittayasothorn, C.-C. Chan, R. R. Caspi* (USA)

P211 MUCOSAL VACCINE ADJUVANT CYCLIC DI-GMP ACTIVATES PULMONARY CD11B+ DENDRITIC CELLS IN A TNFΑ-DEPENDENT MANNER IN VIVO / S. Mansouri*, S. Blaauboer, L. Jin (USA)

P212 LINKING MIF AND NLRP3 IN THE PATHOGENESIS OF IL-1 DEPENDENT INFLAMMATORY DISORDERS / T. Lang*, J. Lee, A. Pinar, H. Fan, Q. Cheng, A. Mansell, E. Morand, J. Harris (Australia)

P213 TSLP SIGNALING IN CD4 T CELLS PRIMES PATHOGENIC TH2 RESPONSES / Y. Rochman*, W. J. Leonard, H. Singh (USA)

P213-b A LITERATURE DERIVED IMMUNE INTER-CELLULAR COMMUNICATION NETWORK REVEALS NOVEL INTERACTIONS AND DISEASE RELATIONS / K. Kveler, A. Ziv-Kenet, E. Starosvetsky, Y. Kalugny, Y. Gorelik, G. Shalev-Malul, N. Aizenbud-Reshef, T. Dubovik, J. Campbell, J. Rieckmann, N. Asbeh, D. Rimar, F. Meissner, J. Wiser, S. Shen-Orr* (Israel)


Innate lymphoid cells: first responders in immunity and inflammation

P214 FATTY ACID METABOLISM SUSTAINS ILC2 MEDIATED BARRIER IMMUNITY DURING INFECTION AND MALNUTRITION / C. Wilhelm*, O. Harrison, V. Schmitt, M. Pelletier , S. Spencer, J. Urban, R. Siegel, Y. Belkaid (Germany)

P215 ESSENTIAL ROLES OF STAT5 TETRAMERS IN THE MATURATION AND SURVIVAL OF NATURAL KILLER CELLS / N. Du*, J.-X. Lin, P. Li, R. Spolski, W. J. Leonard (USA)

P216 A MICRORNA REGULATION OF TYPE 2 INNATE LYMPHOID CELLS- PROMOTES TH2 CYTOKINE PRODUCTION AND INDUCES ALLERGIC INFLAMMATION / P. B. Singh*, H. H. Pua, D. Baumjohann, C. Schneider, J. Von Moltke , R. M. Locksley, K. M. Ansel (USA)

P217 CIS IS A POTENT CHECKPOINT IN NK CELL-MEDIATED TUMOR IMMUNITY / R. B. Delconte, T. B. Kolesnik, L. F. Dagley, W. Shi, E. M. Putz, J.-G. Zhang, P. P. Sharp, G. Infusini, N. P. Liau, E. M. Linossi, C. J. Burns, A. I. Webb, G. T. Belz, W. S. Alexander, J. J. Babon, M. J. Smyth, S. E. Nicholson*, N. D. Huntington (Australia)

P218-b A NOVEL ROLE FOR IL-1 FAMILY CYTOKINES IN REGULATING ILC2 FUNCTION AND PLASTICITY; BIOLOGICAL RELEVANCE TO COPD / J. Silver*, Y. Ohne, J. Kearley, A. Copenhaver, L.-A. T. Snipes, L. Yu, G. H. Pritchard, A. Berlin, C. Hunter, R. Bowler, J. Erjefalt, R. Kolbeck, Y.-J. Liu, A. Humbles (USA)

Inflammation and autoimmunity II

P220 BACE1 IS A NOVEL REGULATOR OF IL-17 PRODUCTION BY TH17 CELLS IN AUTOIMMUNE INFLAMMATION / M. Mcgeachy*, G. Hernandez Mir (USA)

P221 TOFACITINIB REDUCES CIRCULATING CYTOKINES, EXPRESSION OF INTERFERON-DEPENDENT GENES AND VASCULAR DAMAGE IN MURINE LUPUS / Y. Furumoto, C. K. Smith, L. Blanco, W. Zhao, W. L. Tsai, V. Hoffmann, L. Nuñez, G. Sciumè, S. G. Thaker, A. T. Remaley, J. J. O’Shea, M. J. Kaplan, M. Gadina* (USA)

P222 UNUSUAL REGULATION OF INFLAMMASOME SIGNALING IN BATS / M. Ahn*, A. T. Irving, L.-F. Wang (Singapore)

P224 NON-CHEMOTACTIC FUNCTION OF CHEMOKINE RECEPTOR CCR6 IN THE DIFFERENTIATION AND FUNCTION OF TH17 AND TREG CELLS / N. Kulkarni*, G. Lal (India)

P225 CLINICAL STUDY OF PROTEIN CHIP DETECTION OF H. PYLORI IN IMMUNE THROMBOCYTOPENIC PURPURA / Q. Shi*, J. Ni, W. Wu, X. Sun, P. Xu, M. Zhu, J. Gu (China)

P226 HELMINTH-DERIVED PRODUCTS PROTECT AGAINST AUTOIMMUNITY / R. Walsh*, C. Finlay, W. McCormack, H. Kavanagh, O. Mulhern, K. H. G. Mills (Ireland)

P227 ANTIGEN-INDEPENDENT INNATE IMMUNE TRAINING CAN PREVENT AUTOIMMUNE DISEASE / S. Quinn*, A. Malara, K. Mills (Ireland)

P228 NCX 2121, A NITRIC OXIDE-RELEASING DERIVATIVE OF INDOMETHACIN, INHIBITS PREVOTELLA INTERMEDIA LIPOPOLYSACCHARIDE-INDUCED PRODUCTION OF NITRIC OXIDE AND IL-1Β IN MURINE MACROPHAGES / S.-J. Kim*, E.-Y. Choi, S.-H. Choe, I. S. Choi (Republic of Korea)

P229 PHENOTYPIC CONSEQUENCES OF THE CONDITIONAL DELETION OF STRAWBERRY NOTCH HOMOLOG 2 FROM ASTROCYTES IN THE BRAIN OF MICE / T. E. Syme*, M. Grill, I. L. Campbell (Australia)

P230 SINGLE CELL GENE EXPRESSION STUDIES IN LUPUS PATIENT MONOCYTES REVEAL NOVEL PATTERNS REFLECTING DISEASE ACTIVITY, INTERFERON, AND MEDICAL TREATMENT / Z. Jin, W. Fan, M. A. Jensen, J. M. Dorschner, D. M. Vsetecka, S. Amin, A. Makol, F. Ernste, T. Osborn, K. Moder, V. Chowdhary, T. B. Niewold* (USA)

P230-b SOLUBLE CD40L-DEPENDENT PATHWAY IS ACTIVE IN EARLY AND ESTABLISHED RHEUMATOID ARTHRITIS / Y. Guo*, A. Walsh, U. Fearon, M. Smith, M. Wechaleker, X. Yin, S. Cole, C. Orr, S. Kelley, X. Liu, D. Veale, C. Pitzalis, S. Nagpal (USA)

P230-c THE ROLE OF TISSUE TREGS AND IL-33 DURING ORGAN INJURY AND REGENERATION / F. Do Valle Duraes*, P. Smith, U. Naumann, V. Boehler, G. Wieczorek, C. Cojean, F. Hillger, A. Littlewood-Evans, J. Li, M. Warncke (Switzerland)

Sponsored poster by Boehringer Ingelheim

Pharmacologic evidence qualifying role of LAT1 (SLC7A5) neutral amino acid transporter in promoting growth, differentiation and cytokine production of human T lymphocyte subsets

A. Eyzaguirre, J. Eun Lee, B. Bleck, J. Woska, K. Sai, M.O’Connor, M. Taub, M. Netherton, C. E. Whitehurst

www.jem.org

Outstanding ScienceThe Journal of Experimental Medicine congratulates JEM Editor Carl Nathan, JEM Advisory Editor John J. O’Shea, and Jan Vilcek for receiving the Seymour and Vivian Milstein Award for Excellence in Interferon and Cytokine Research, which recognizes biomedical research scientists who have made outstanding contributions to the � eld.

JEM features peer-reviewed research on immunology, cancer biology, stem cell biology, microbial pathogenesis, vascular biology, and neurobiology. See the special collection of articles selected for their relevance to the International Cytokine and Interferon Society Meeting at

bit.ly/Cytokine.

Credit: International Cytokine and Interferon Society

Past Milstein Award Laureates Include:

2012 Jean-Laurent Casanova

JEM Editor

2008 Giorgio Trinchieri JEM Advisory Editor

2007 Shizuo Akira

JEM Advisory Editor

Dr. John O’Shea

Dr. Carl Nathan

Dr. Jan Vilcek


Seymour and Vivian Milstein Award for Excellence in Interferon and Cytokine ResearchJohn O’Shea, M.D., Ph.D., National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS),National Institutes of Health (NIH), USADr. O’Shea shares the 2016 Seymour & Vivian Milstein Award for his outstanding research on how cytokines transmit signals to the cell interior to invoke and direct subsequent immune responses, particularly in relation to his work on T lymphocytes.

Carl Nathan, M.D., Ph.D., Weill Cornell Medical College, USADr. Nathan shares the 2016 Seymour & Vivian Milstein Award for his pioneering work in immunology, microbiology, infectious diseases and global health, defining how cytokines play a pivotal role in infectious diseases such as tuberculosis.

Jan Vilcek, M.D., Ph.D., New York University School of Medicine, USADr. Vilcek shares the 2016 Seymour & Vivian Milstein Award for his outstanding track record of sustained, high caliber research, particularly in relation to his work with TNF-a, that has transformed health care in relation to autoimmune diseases.

Honorary Life MembershipHoward Young, Ph.D., National Cancer Institute, National Institutes of Health (NIH), USADr. Young receives the 2016 Honorary Life Membership Award for his exemplary contributions in the field of innate immunity, delineating how cytokines regulate the functions of immune cells in specific diseases.

ICIS-BioLegend Bill Paul AwardRichard Locksley, UCSF, USAThis new award is given to an investigator that has made significant contributions to cytokine and interferon research throughout their career. Through the generosity of BioLegend the award consists of $2500 and a crystal block with the3 D structure of IL-4, the cytokine most associated with Dr. Paul’s research.

The Milstein Young Investigator AwardAndreas Bergthaler, CeMM, Austrian Academy of Sciences, AustriaSi Ming Man, St. Jude Children’s Research Hospital, USADi Yu, Monash University, AustraliaVineet D. Menachery, University of North Carolina, USA

Christina Fleischmann Award to Young Women InvestigatorsMichelle D. Tate, Hudson Institute of Medical Research, Australia

Sidney & Joan Pestka Graduate Award in Interferon ResearchRhiannon Werder, University of Queensland, Australia

Sidney & Joan Pestka Post-Graduate Award in Interferon ResearchScott Read, Westmead Institute for Medical Research, Australia

AWARDS WINNERS


The Milstein Travel AwardsObajemu Adeola (USA)Inna Afonina (Belgium)Jeonghyun Ahn (USA)Nilesh Amatya (USA)Florence Anquetil (USA)Annabell Bachem (Australia)Paul Baker (Australia)Betsy Barnes (USA)Cristina Bergamaschi (USA)Katharina Borst (Germany)Anna Cardus (UK)Kwan Chow (USA)J. Agustin Cruz (USA)Simone Dallari (USA)Pamela De La Cruz-Rivera (USA)Nicole De Weerd (Australia)Pratik Deb (USA)Virginie Deswaerte (Australia)Lydia Dyck (Ireland)Holl Eduarta (USA)Wan Edwin Chi-Keung (USA)Emily Eshleman (USA)Eric Feeley (USA)Ryan Finethy (USA)Nicolette Fonseca (Canada)Raffi Gugasyan (Australia)

David Hare (Canada)Zerina Hodzic (USA)Curt Horvath (USA)Hiroyasu Konno (USA)Tali Lang (Australia)Andrew Larner (USA)Laurel Lenz (USA)Dan Li (USA)Jian-Da Lin (USA)Edmond Linossi (Australia)Nicola Lorè (Italy)Jason Lynch (Australia)Samuel Maldonado (USA)Katrina Mar (USA)Kazuya MASUDA (Japan)Constance McElrath (USA)Amina Negash (USA)Estanislao Nistal-Villan (Spain)Mohammed Nooruzzaman (Bangladesh)Olusegun Onabajo (USA)Lisa Osborne (Canada)Genevieve Pepin (Australia)Maya Poffenberger (Canada)Shauna Quinn (Ireland)Aradhana Rani (UK)

Mathilde Raverdeau (Ireland)Nick Rinkenberger (USA)Yrina Rochman (USA)Giovanna Romeo (Italy)Grigory Ryzhakov (UK)Diana Saleiro (USA)Kimberly Schluns (USA)Johannes Schwerk (USA)Laura Snell (Canada)Jeewon So (USA)Julia Spanier (Germany)Sebastian Stifter (Australia)Taylor Syme (Australia)Chafia Touil-Boukoffa (Algeria)Johan Van Weyenbergh (Belgium)Barney Viengkhou (Australia)Robert Walsh (Ireland)FANG WANG (USA)Xin Wang (USA)Yuxin Wang (USA)Phillip West (Australia)Paul Whitney (Australia)Christoph Wilhelm (Germany)Junji Xing (USA)Annett Ziegler (Germany)

AWARD PRESENTATIONS

Sunday 16 October – 17:00-17:30 – Grand Ballroom A

2016 Milstein Award LectureCarl Nathan, Weill Cornell Medical College, USA

Tuesday 18 October – 14:00-14:45 – Grand Ballroom A

ICIS-BioLegend Bill Paul Award LectureRichard Locksley, UCSF, USA

Tuesday 18 October – 16:45-17:00 – Grand Ballroom A

Christina Fleischmann Award to Young Women InvestigatorsMichelle D. Tate, Hudson Institute of Medical Research, Australia

Tuesday 18 October – 16:45-17:00 – Grand Ballroom B/C

The Sidney & Joan Pestka Post Graduate Award presentationsScott Read, Westmead Institute for Medical Research, Australia

Wednesday 19 October – 12:30-13:00 – Grand Ballroom A

2016 Milstein Award LectureJohn O’Shea, NIAMS / NIH, USA


COMPANY PROFILES

Amgen Sponsor

Website: www.amgen.com

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.

Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people’s lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world’s leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

For more information, visit www.amgen.com and follow us on www.twitter.com/amgen.

BioLegend Booth n° 11

Email: [email protected]: 1-877-BIOLEGENDWebsite: www.biolegend.com

BioLegend develops and manufactures highly recognized, world-class antibodies and reagents at an outstanding value to customers for biomedical research. Our broad product portfolio includes flow cytometry, cell biology, and biofunctional molecules for research in immunology, neuroscience, cancer, cell biology, stem cells, and more. Our aggressive product development program, accomplished through technology licensing, collaborations, and internal research and development, has produced a product offering of over 17,000 products, which have been collectively cited in over 25,000 peer-reviewed journals. BioLegend also offers a wide range of custom services including assay development, sample testing, and conjugation. BioLegend’s reagents are supported by superior customer service and a quality management system dedicated to continuous improvement that is certified for ISO 9001:2008 and ISO 13485:2003.

Bio-Techne Booth no 9

Email: [email protected]: +1 612 379-2956Website: www.bio-techne.com

Bio-Techne brings together the world class brands of R&D Systems, Novus Biologicals, Tocris, and ProteinSimple to better serve our customers and the community. R&D Systems cytokines defined the industry 30 years ago and continue to provide researchers with reliable research results. As the Bio-Techne portfolio grows, we are no longer just about consumables. We are adding innovative instruments to our portfolio in a way that allows us to leverage our gold standard reagents into complete solutions for both life science and diagnostic markets.

eBioscience, Part of Thermo Fisher Scientific Booth no 3

Email: [email protected]: 888.999.1371Website: www.ebioscience.com

eBioscience, Part of Thermo Fisher Scientific, develops and manufactures over 12,000 antibodies, proteins, immunoassays and multiplex assays at ISO-certified facilities worldwide. Focused on accelerating immunologic discoveries with reagents to measure gene and protein expression in single cells, we provide innovative solutions to researchers and clinicians looking to answer questions driving today’s life science communities. Partner with the industry leader of translational science.


ICIS 2017 Booth no 13

Email: [email protected]

Phone: +81-3-3508-1214

Website: www.icis2017japan.com

The 5th Annual Meeting of the International Cytokine and Interferon Society, ICIS 2017, will be held in Kanazawa, Japan, from 29th October – 2nd November 2017, under the theme of “Looking beyond the horizon of integrated cytokine, interferon and chemokine research”. Please visit our booth for more information!

Janssen Research & Development, LLC Sponsor


Phone: (215) 628-5000

Website: www.janssen.com

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com. Follow us on Twitter at https://twitter.com/JanssenGlobal.

Meso Scale Discovery Booth no 2


Phone: 01-240-314-2600

Website: www.mesoscale.com

Meso Scale Discovery (MSD®) is a global leader in developing and manufacturing immunoassay technology for biomedical research, providing high performance, multiplex-enabled assays for cytokines, toxicology, neurodegeneration and metabolic disease biomarkers. Biopharmaceutical and academic researchers employ MSD’s assays to test serum, plasma, cell culture and other biological samples from human and laboratory animal sources. MSD’s proprietary electrochemiluminescence (ECL) platform delivers exceptional sensitivity, wide dynamic range and a convenient workflow that enables processing of a large number of samples in a limited time. MSD also offers assay development services for customers requiring a turnkey solution for biomarker studies.

MilliporeSigma Booth no 16


Phone: 1-781-533-6000

Website: www.emdmillipore.com

MilliporeSigma is the U.S. life science business of Merck KGaA, Darmstadt, Germany. With 19,000 employees and 72 manufacturing sites worldwide, MilliporeSigma’s portfolio spans more than 300,000 products enabling scientific discovery. MilliporeSigma has customers in life science companies, university and government institutions, hospitals and industry. More than 1 million scientists and technologists use its products. The company is committed to solving the toughest problems in life science by collaborating with the global scientific community. For more information, visit www.emdmillipore.com and www.sigma-aldrich.com.


PeproTech, Inc. Booth no 1


Phone: 1-800-436-9910

Website: www.peprotech.com

PeproTech creates the building blocks of your life science research by manufacturing high-quality products that advance scientific discovery and human health. Since 1988, PeproTech has grown into a global enterprise manufacturing an extensive line of Recombinant Human, Murine and Rat Cytokines, Animal-Free Recombinant Cytokines, Monoclonal Antibodies, Affinity Purified Polyclonal Antibodies, Affinity Purified Biotinylated Polyclonal Antibodies, ELISA Development Kits, Cell Culture Media Products and GMP Cytokines.

Pfizer Sponsor

Email: Sophie Park, [email protected]

Phone: 617-820-8758

Website: www.pfizer.com

At Pfizer, we apply science and our global resources to bring therapies to people that extend and significantly improve their lives through the discovery, development and manufacture of healthcare products. Our global portfolio includes medicines and vaccines, as well as many of the world’s best-known consumer healthcare products. We work across developed and emerging markets to advance wellness, prevention, treatments and cures that challenge the most feared diseases of our time. We collaborate with healthcare providers, governments and local communities to support and expand access to reliable, affordable healthcare around the world.

Quanterix Booth no 12

Email:

Phone:

Website:

Founded in 2007, Quanterix offers an ultra-sensitive diagnostic platform capable of measuring individual proteins at concentrations 1000 times lower than the best immunoassays available today. The Single Molecule Array (Simoa) technology at the heart of the platform enables the detection and quantification of biomarkers previously difficult or impossible to measure, opening up new applications to address significant commercial unmet needs in life science research, in-vitro diagnostics, companion diagnostics, blood screening, and more.

Sanofi Sponsor


Phone: +1 800-981-2491

Website: www.sanofi.com

Sanofi, a global healthcare leader, discovers, develops and distributes therapeutic solutions focused on patients’ needs. Sanofi is organized into five global business units: Diabetes and Cardiovascular, General Medicines and Emerging Markets, Sanofi Genzyme, Sanofi Pasteur and Merial. Sanofi is listed in Paris (EURONEXT: SAN) and in New York (NYSE: SNY). Sanofi Genzyme focuses on developing specialty treatments for debilitating diseases that are often difficult to diagnose and treat, providing hope to patients and their families.


LAYOUT OF VENUE & EXHIBITION AREA

Floor Plan - Street Level

Exhibition Floor Plan - Pacific concourse levelLevel -1

COMPANY NAME Booth no

Biolegend 11

Bio-Techne 9

eBiosciences An Affymetrix Business

3

Elsevier United Kingdom 5

ICIS 2017 13

Meso Scale Discovery 2

Millipore Sigma 16

PeproTech, Inc. 1

Quanterix 12

Sinobiological 7

ENTRANCEENTRANCE

TELEPHONES

EXIT

RESTROOM

RESTROOM

EXIT EXIT

EXIT

EXIT

SERV.

EXIT

EXIT

EXIT

EXIT

EXIT

FREIGHTDOOR

EXIT

EXIT

DOORFREIGHT

0' 10'

SCALE

30'

F&B

F&B

F&B

F&B

Inte

rnet

Cor

ner

03

05

07

09111213

16

01 02

123 4

567 8

10 9

13

17

21

26

29

71

12

16

20

24

28

30

14

18

22

25

11

15

19

23

27

31 33 35 37 39 41 43 45 47

32 34 36 38 40 42 44 46 48

72

6059

58

56

54

52

50

57

55

53

51

49

70 68 66 64

69 67 65 63

6162

6' T

Dra

ped

6' T Draped

6' T Draped

Freeman Service Desk

CYTOKINES 2016OCTOBER 16 - 19, 2016

HYATT REGENCY-PACIFIC CONCOURSE D-OSAN FRANCISCO, CA

36 - 8' DOUBLE SIDED PB'S72 - TOTAL SIDES

3M X 6M BOOTHS - 23M X 3M BOOTHS - 9

DOORFREIGHT

10/4/2016 Bryan Feige - SF

SHERIE KAO

PROPOSED

PACIFIC CONCOURSE

P:\San Francisco\Branch\Design\Floorplans\Shows\2016\10-October\IntlCytokine Society (428836)\DWG Files\Intl Cytokine Society 1016.DWG

INTL CYTOKINE SOCIETY 1016

6/13/2016 AL

10.15

HYATT REGENCY SAN FRANCISCO5 Embarcadero CenterSan Francisco, CA 94111USA

T +1 415 788 1234F +1 415 398 2567sanfranciscoregency.hyatt.com

FLOOR PLANStreet Level

REGENCYA

PLAZA ROOM

REGENCY B

WOMEN'S LOUNGE

MEN'S LOUNGE

GRANDBALLROOM

A

ELEVATORS

CAR RENTAL DESK

MARKET STREET

MA

IN H

OT

EL

EN

TR

AN

CE

DR

UM

M S

TR

EE

T

VALE

T E

NT

RA

NC

E

ESCALATORS

GRANDBALLROOM

B

GRANDBALLROOM

FOYER

GRANDBALLROOM

C

VALETPARKING

ELEVATOR

MARKET STREETFOYER

10.15




REGENCYA

PLAZA ROOM

REGENCY B

WOMEN'S LOUNGE

MEN'S LOUNGE

GRANDBALLROOM

A

ELEVATORS

CAR RENTAL DESK

MARKET STREET

MA

IN H

OT

EL

EN

TR

AN

CE

DR

UM

M S

TR

EE

T

VALE

T E

NT

RA

NC

E

ESCALATORS

GRANDBALLROOM

B

GRANDBALLROOM

FOYER

GRANDBALLROOM

C

VALETPARKING

ELEVATOR

MARKET STREETFOYER

Speakerpreview room

10.15




REGENCYA

PLAZA ROOM

REGENCY B

WOMEN'S LOUNGE

MEN'S LOUNGE

GRANDBALLROOM

A

ELEVATORS

CAR RENTAL DESK

MARKET STREET

MA

IN H

OT

EL

EN

TR

AN

CE

DR

UM

M S

TR

EE

T

VALE

T E

NT

RA

NC

E

ESCALATORS

GRANDBALLROOM

B

GRANDBALLROOM

FOYER

GRANDBALLROOM

C

VALETPARKING

ELEVATOR

MARKET STREETFOYER

10.15




REGENCYA

PLAZA ROOM

REGENCY B

WOMEN'S LOUNGE

MEN'S LOUNGE

GRANDBALLROOM

A

ELEVATORS

CAR RENTAL DESK

MARKET STREET

MA

IN H

OT

EL

EN

TR

AN

CE

DR

UM

M S

TR

EE

T

VALE

T E

NT

RA

NC

E

ESCALATORS

GRANDBALLROOM

B

GRANDBALLROOM

FOYER

GRANDBALLROOM

C

VALETPARKING

ELEVATOR

MARKET STREETFOYER

Regi

stra

tion

10.15




REGENCYA

PLAZA ROOM

REGENCY B

WOMEN'S LOUNGE

MEN'S LOUNGE

GRANDBALLROOM

A

ELEVATORS

CAR RENTAL DESK

MARKET STREET

MA

IN H

OT

EL

EN

TR

AN

CE

DR

UM

M S

TR

EE

T

VALE

T E

NT

RA

NC

E

ESCALATORS

GRANDBALLROOM

B

GRANDBALLROOM

FOYER

GRANDBALLROOM

C

VALETPARKING

ELEVATOR

MARKET STREETFOYER

Access toExhibitionandPostersLevel -1

Sessions

Sessions

10.15




REGENCYA

PLAZA ROOM

REGENCY B

WOMEN'S LOUNGE

MEN'S LOUNGE

GRANDBALLROOM

A

ELEVATORS

CAR RENTAL DESK

MARKET STREET

MA

IN H

OT

EL

EN

TR

AN

CE

DR

UM

M S

TR

EE

T

VALE

T E

NT

RA

NC

E

ESCALATORS

GRANDBALLROOM

B

GRANDBALLROOM

FOYER

GRANDBALLROOM

C

VALETPARKING

ELEVATOR

MARKET STREETFOYER

10.15




REGENCYA

PLAZA ROOM

REGENCY B

WOMEN'S LOUNGE

MEN'S LOUNGE

GRANDBALLROOM

A

ELEVATORS

CAR RENTAL DESK

MARKET STREET

MA

IN H

OT

EL

EN

TR

AN

CE

DR

UM

M S

TR

EE

T

VALE

T E

NT

RA

NC

E

ESCALATORS

GRANDBALLROOM

B

GRANDBALLROOM

FOYER

GRANDBALLROOM

C

VALETPARKING

ELEVATOR

MARKET STREETFOYER


MEETING VENUE AND LOCATIONHyatt Regency San Francisco5 Embarcadero CenterSan Francisco, California, USA, 94111Phone: +1 415 788 1234Fax: +1 415 398 2567

MEETING ORGANISER MCI Suisse SA has been selected by ICIS as the official meeting organiser to process registrations, hotel reservations, abstract management, exhibition and sponsorship. All correspondence should be sent to:

Cytokines 2016c/o MCI Suisse SA 9 Rue de Pré-Bouvier1242, Satigny, Geneva, Switzerland General contact: [email protected]

MEETING DOCUMENTS AND BADGESMeeting documents should be collected on-site at the registration desk at the Hyatt Regency - Grand Ballroom Foyer - Ground Level. Name badges must be worn visibly all times during the meeting and in the exhibition area.

MOBILE APPLICATIONGet all information you need at your fingertips with the Cytokines 2016 Mobile Application, sponsored by Janssen.It is available for free on iOS and Android.

CELLULAR PHONES AND PAGERSAs a courtesy to all meeting attendees and speakers, cellular phones, pagers and other electronic devices must be operated in silent or vibration mode during sessions. No cellular phone conversations are permitted during sessions.

CERTIFICATE OF ATTENDANCEA certificate of attendance will be sent by email after the meeting to all duly registered participants who attended the meeting.

CYBER CAFÉAn internet corner is located in the exhibition area and is available to all meeting participants during the opening hours of the exhibition. Cyber Cafe kindly supported by Amgen.

FOOD AND BEVERAGEComplimentary coffee and tea is served in the exhibition during official coffee breaks. Lunch is not provided. There are several restaurants within walking distance of the Hyatt Regency building.

SAN FRANCISCOSan Francisco is often called “Everybody’s Favorite City,” a title earned by its scenic beauty, cultural attractions, diverse communities, and world-class cuisine. Measuring 49 square miles, this very walk-able city is dotted with landmarks like the Golden Gate Bridge, cable cars, Alcatraz and the largest Chinatown in the USA. A stroll of the City’s streets can lead from Union Square to North Beach to Fisherman’s Wharf, with intriguing neighborhoods to explore at every turn. Views of the Pacific Ocean and San Francisco Bay are often laced with fog, creating a romantic mood in this most European of American cities.

GETTING AROUND IN SAN FRANCISCO

MUNISan Francisco Municipal operates buses, trains, cable cars & the F-line heritage streetcar. The MUNI buses remain above ground while MUNI metro runs on rails and sometimes go underground. Bus stops come in many forms; small bus

GENERAL INFORMATION

Android iOS


shelters, yellow paint on street poles, and white paint on streets. Metro stops can be found on an island in the middle of the street and stations. Using the Metro Map, find the nearest metro to your locations.

Cable CarsCable Cars and street cars are San Francisco’s historical cars and run along cables that are affixed to the street. Cable Cars are located downtown and run on three lines; Powell-Hyde, Powell-Mason, and California St. The F-Line Street Car runs up and down Market St. all the way to Fisherman’s Wharf. For these you may pay the conductor on board or purchase tickets at multiple locations.

Ride SharingUber and Lyft are car services operated by San Francisco locals. You must first download the app, register, and set-up a credit card payment system. With Lyft, you can request a private car service, or use the shared car service called “Lyft Line”. This is useful when travelling with another person because you get a shared discounted rate. Uber has a similar service called “Uber Pool” with rides running at a flat rate of $7. To use any of these services, set a pick-up location and end destination and within minutes, you will be matched with a driver. Make sure to communicate with your driver; call, text, or wave down their car.

As is customary in most U.S. Cities, visitors may hail a taxi directly or use a smart phone app.

INTERNETFree wireless internet access is brought to you by Sanofi-GenzymeWiFi Name: Sanofi Genzyme Cytokine 2016 / Password: SGC-2016

OFFICIAL LANGUAGEThe official meeting language is English. No simultaneous interpretation will be available.

SMOKING POLICYThe meeting venue is entirely non-smoking.

SURVEY/MEETING EVALUATIONWe would be grateful if you can take a few minutes to answer an online survey that will be sent to you shortly after the meeting. Your valuable feedback will help us to improve the organisation and quality of future Cytokine meetings.

REGISTRATION DESK OPENING HOURSSunday 16 October 14:00 - 20:00Monday 17 October 07:30 - 19:00Tuesday 18 October 08:00 - 17:00Wednesday 19 October 08:00 - 13:30

SPEAKER’S PREVIEW ROOM OPENING HOURSSunday 16 October 14:00 - 18:00Monday 17 October 07:30 - 17:00Tuesday 18 October 08:00 - 17:00Wednesday 19 October 08:00 - 13:30

All speakers are requested to upload their presentation at least 2 hours before their session, or the day before for the early morning sessions.

EXHIBITION OPENING HOURSSunday 16 October 18:00 - 20:00Monday 17 October 10:00 - 19:00Tuesday 18 October 09:30 - 16:30Wednesday 19 October 09:30 - 13:00

TRAVEL INSURANCEIt is recommended that participants obtain adequate cover for travel, health and accident insurance before they depart from their countries. Cytokines 2016 and MCI Suisse S.A. as organizers cannot accept responsibility for personal injuries, or loss of, or damage to, private property belonging to the delegates and accompanying persons.

WEBSITEwww.cytokines2016.com


Welcome Reception & Networking Sunday 16 October, 18:30-19:30 in the exhibition area, at the meeting venue

All registered participants are cordially invited to take the opportunity to meet with colleagues from all over the world, at the Meet and Greet reception.

Poster SessionsMonday and Tuesday in the poster area, at the meeting venue

– Monday 17 October 17:00 - 19:00– Tuesday 18 October 13:30 - 15:00

Have an informal face-to-face meeting with researchers, students and colleagues who will be the utmost pleased to share their work and latest innovations with you, through poster presentation.

Lunchtime Trainee Career Panel DiscussionMonday 17 October 13:00-14:00 in room Seacliff A-C, at the meeting venue With the kind support of Science Signaling

Trainees registered at the meeting are cordially invited to attend this lunchtime career panel discussion with senior faculty. A lunch box will be served in limited availability, on a first come, first served basis.

Evening Trainee Networking Event Monday 17 October from 19:30 to 21:30 in the Market street foyer, at the meeting venueFor registered trainees only, limited availability

With the kind support of Bio-Techne

Enjoy this special evening reserved for trainee to meet with invited senior faculty.

ICIS Farewell reception Tuesday 18 October from 17:30 to 19:30 at La MarUpon registration, limited availability

La Mar SFPier 1 ½, the EmbarcaderoSan Francisco, CA 94111

Meet colleagues from all over the world enjoy a refined cocktail reception.

Inspired on the thousands of Cebicherias found throughout Peru, La Mar, was created as an attempt to globalize and enshrine one of the best guarded treasures of Peruvian cuisine Cebiche.

A clean minimalist décor preserves the beauty of this classic building with an added Peruvian flare. Enter the historic Pier 1½ lobby to find multiple lounges, an expansive dining room and a waterfront patio overlooking Treasure Island.

NETWORKING EVENTS

Department of Molecular Preventive Medicine, The University of TokyoKouji Matsushima M.D., Ph.D.

Ishikawa Ongakudo ANA CROWNE PLAZA KANAZAWA

Chair

Venue

Cytokines 2O17yThe 5th Annual Meeting of the International Cytokine andInterferon Society (ICIS 2017)

okines 2O17The 5th Annual Meeting of the International Cytokine andThe 5th Annual Meeting of the International Cytokine andInterferon Society (ICIS 2017)

www.icis2017japan.com

Looking beyond the horizon of integratedcytokine research

Looking beyond the horizon of integratedcytokine research

in Kanazawa, Japan

October 29 (Sun.) November 2 (Thu.) , 2017

Co-organizationJapanese Society of Interferon and Cytokine ResearchJapanese Society of Molecular Cell Biology of Macrophages

Co-organizationJapanese Society of Interferon and Cytokine ResearchJapanese Society of Molecular Cell Biology of Macrophages

Date post:	21-Jul-2020
Category:	Documents
Upload:	others
View:	0 times
Download:	0 times

FINAL PROGRAM · 2018-09-01 · 3 03 Committees 04 Welcome Message 05 Acknowledgements 06 Program...

Documents