Firms that produce, analyse, or use biological systems on a micro-, cellular-, or molecular level or firms that develops tools and supplies for these purposes.

Biotechnology

FoodAgriculture

PharmaceuticalsMedical Technology

ForestryPulp & Paper Environment

Instruments & equipment

Chemistry

THE BIOTECH INDUSTRY:

• Agrobiotechnology - plant improvement and biological plant protection

• Bioproduction - biomolecular or micro-organism production

• Biotech tools and supplies - services, processes, equipment and instruments for biotechnological use

• Environmental biotechnology - soil, water, and waste treatment

• Functional food and feed - mainly probiotics

• Pharmaceuticals and medicine - drug discovery and drug development, diagnostics and medical technology

The Swedish biotech industry

Number of biotechnology companies in different countries year 2000

0

200

400

600

800

1000

1200

1400

No

. of

Co

mp

anie

s

US

AJa

pan

Ko

rea

Can

ada

Ger

man

yU

KC

hin

aF

ran

ceS

wed

enS

pai

nIt

aly

Au

stra

liaIs

rael

Tai

wan

Net

her

lan

ds

Fin

lan

d

Sw

itze

rlan

dD

enm

ark

Bel

giu

mN

orw

ayR

uss

ia

So

uth

Afr

ica

Ind

iaE

sto

nia

Lat

via

Lit

hu

ania

Po

lan

dS

lova

kia

Country

0

200

400

600

800

1000

1200

1400

No

. of

Co

mp

anie

s

US

AJa

pan

Ko

rea

Can

ada

Ger

man

yU

KC

hin

aF

ran

ceS

wed

enS

pai

nIt

aly

Au

stra

liaIs

rael

Tai

wan

Net

her

lan

ds

Fin

lan

d

Sw

itze

rlan

dD

enm

ark

Bel

giu

mN

orw

ayR

uss

ia

So

uth

Afr

ica

Ind

iaE

sto

nia

Lat

via

Lit

hu

ania

Po

lan

dS

lova

kia

Country

Source: The Swedish Trade council, ”Global perspectives on bioscience 2002”

*

Number of companies and employees

Year

2677

32333391

3760

3975

0

20

40

60

80

100

120

140

160

180

200

1997 1998 1999 2000 20010

500

1000

1500

2000

2500

3000

3500

4000

4500

Number ofcompanies

Number ofemployees

The regional distribution of the Swedish biotech industry 1999*

* The sizes of the circles are proportional to the number of employees/companies. Only micro-, and small sized companies (<200 employees) are included. The distribution is based on the seat of the county government.

No. of employees No. of companies

Number of companies

0

20

40

60

80

100

120

1997 1998 1999 2000 2001

Agrobiotechnology

Bioproduction

Biotech tools & supplies

Environmental biotechnology

Functional food & feed

Pharmaceuticals & medicine

Number of companies

Year

Number of employees

0

500

1000

1500

2000

2500

1997 1998 1999 2000 2001

Agrobiotechnology

Bioproduction

Biotech tools & supplies

Environmental biotechnology

Functional food & feed

Pharmaceuticals & medicine

Number ofemployees

Year

Turnover

0

500

1000

1500

2000

2500

1997 1998 1999 2000Year

Turnover (MSEK) Agrobiotechnology

Bioproduction

Biotech tools & supplies

Environmental biotechnology

Functional food & feed

Pharmaceuticals & medicine

Number of companies pharmaceuticals & medicine

0

10

20

30

40

50

60

1997 1998 1999 2000 2001

Diagnostics

Drug delivery

Drug discovery & development

Medical technology

Number of companies

Year

Number of employees in pharmaceuticals & medicine

0

200

400

600

800

1000

1200

1997 1998 1999 2000 2001

Diagnostics

Drug delivery

Drug discovery & development

Medical technology

Number of employees

Year

Median equity/assets ratio

Year

20

30

40

50

60

70

80

1997 1998 1999 2000

Finacial strength, median (%) Agrobiotechnology

Bioproduction

Biotech tools & supplies

Environmental biotechnology

Functional food & feed

Pharmaceuticals & medicine

Net profits/losses in surviving companies in the different biotech sectors, 1998 – 2001

-1200

-1000

-800

-600

-400

-200

0

200

1998 1999 2000 2001

Year

MSEK

Total

Agrobiotechnology

Bioproduction

Biotech tools & supplies

Environmental biotechnology

Functional food & feed

Pharmaceuticals & medicine

Share of surviving companies with net profit 1998-2001 in total and in each sector

0

20

40

60

80

100

1998 1999 2000 2001Year

Per centAgrobiotechnology

Bioproduction

Biotech tools & supplies

Environmental biotechnology

Functional food & feed

Pharmaceuticals & medicine

Total

Size of sector in Sweden• PHARMACEUTICALS AND MEDICAL TECHNOLOGY

Approximately 30 000 employees and a turnover of 60 billion SEK

• BIOTECHNOLOGY

• The fourth largest biotechnology industry in Europe after Great Britain, Germany, and France * and the ninth in the world**

• 183 SMEs (< 500 emp. each), increase by 35% 1997-2001

• About 4000 employees, increase by 48% 1997-2001

• Turnover 4.4 billion SEK (2000), increase by 30 % 1997-2000***

• Increased financial strength and net losses 1997-2001

* European Commission; Ernst & Young** The Swedish Trade Council*** Fixed prices

Reasons for the development

UNTIL 1999• The science base • The presence of Astra and Pharmacia • An internationally growing market • Success stories inspires• Changed attitudes• Good availability of seed and venture capital

CHANGE DURING 2000-2002…2003• Development at the stock exchange• Cautious venture capital companies• Lack of seed capital

The Swedish science base in international comparison

THE SWEDISH SCIENTIFIC PERFORMANCE IN GENERAL

• The trend is increased quantity but at the same time there are signs of decreasing quality.

PERFORMANCE IN A SELECTION OF LIFE SCIENCE FIELDS

• First, second or third ranking of publication volumes in relation to population in the selected seven subject fields.

• Five out of seven fields showed increasing shares of the world’s total publication volume.

• Four out of seven fields showed increased citation levels but still Swedish citation levels are loosing their top position

1986-1989

1990-1993

1994-1997

1998-2001

Total

87-01

Biochemistry & Biophysics 2 2 2 2 2

Biotechnol & Appl Microbiol 3 4 3 1 2

Cell & Developmental Biol 3 3 2 2 2

Immunology 1 2 2 2 2

Microbiology 2 2 4 3 3

Molecular Biology & Genetics 2 2 3 2 2

Neurosciences & Behavior 1 1 1 1 1

Swedish ranking in relation to population 1986-2001

Relative citation levels in biochemistry and biophysics

0.6

1.0

81-8

5

83-8

7

85-8

9

87-9

1

89-9

3

91-9

5

93-9

7

95-9

997

-01

CANADADENMARKEUROPEAN UNIONFINLANDFRANCEGERMANYISRAELNETHERLANDSSWEDENSWITZERLANDUKUSA

1.2

1.4

1.6

0.8

Relative citation levels in neurosciences and behavior

0.4

0.6

0.8

1.0

1.2

1.4

81-8

5

83-8

7

85-8

9

87-9

1

89-9

3

91-9

5

93-9

7

95-9

9

97-0

1

CANADA

DENMARK

EUROPEAN UNION

FINLAND

FRANCE

GERMANY

ISRAEL

NETHERLANDS

SWEDEN

SWITZERLAND

UK

USA

0

5

1 0

1 5

2 0

2 5

3 0

3 5

4 0

1 9 8 7 -1 9 8 9

1 9 9 0 -1 9 9 2

1 9 9 3 -1 9 9 5

1 9 9 6 -1 9 9 8

1 9 9 9 -2 0 0 1

Y e a r

Per cen

t

K A R O L I N S K AI N S TL U N D U N I V

U P P S A L A U N I V

G O T H E N B U R GU N I VU M E A U N I V

S T O C K H O L MU N I VS L U

L I N K O P I N GU N I VS M I

Volume shares for the nine most productive Swedish public research organisations of the total Swedish publication volume

in biotechnology-related science, 1987-2001

Co-authorship pattern between organisations with the largest publication volumes in biotechnology related science 1997-2001

’

0

1

2

3

4

Bioche

mist

ry &

Biop

hysic

s

Biotec

hnol

& App

l Micr

obiol

Cell &

Dev

elopm

enta

l Biol

Imm

unolo

gy

Micr

obiol

ogy

Mole

cular

Biol

ogy &

Gen

etics

Neuro

scien

ces

& Beh

avior

1987-1989

1990-1992

1993-19951996-1998

1999-2001

The Swedish percentage of the world´s total publication volume within a selection of life

science fields during five periods (1987-2001)

0

1

2

Bioche

mist

ry &

Biop

hysic

s

Biotec

hnol

& App

l Micr

obiol

Cell &

Dev

elopm

enta

l Biol

Imm

unolo

gy

Micr

obiol

ogy

Mole

cular

Biol

ogy &

Gen

etics

Neuro

scien

ces

& Beh

avior

87-91

88-92

89-93

90-94

91-95

92-96

93-97

94-98

95-99

96-00

97-01

Relative citation levels for Swedish articles within a selection of life science fields during 1987-1997 (Index world=1)

Inventor origin for biotechnology patents in the US patent system 1987-2001*

USA63,9%

Great Britain3,6%

Canada2,6%

Germany4,6%

Japan11,4%

France2,9%

Other11,0%

* Sweden < 1%

0

1

2

3

MEDIC

AL ELE

CTRONICS

MEDIC

AL EQUIP

MENT

PHARMACEUTIC

ALS

BIOTECHNOLO

GY

MEAN A

LL A

REAS

1987-1989

1990-1992

1993-1995

1996-1998

1999-2001

Swedish inventor shares of the world’s total patenting volume during five periods in different areas compared to the

Swedish average share in all fields 1987-2001

Number of patents for Astra and Pharmacia

0

10

20

30

40

50

60

70

80

1987

1989

1991

1993

1995

1997

1999

2001

YEAR

NU

MB

ER

OF

PA

TE

NT

S

AstraZeneca AB Pharmacia Corporation