pdfcrowd.comopen in browser PRO version Are you a developer? Try out the HTML to PDF API

Featured Research from universities, journals, and other organizations

Date:

Source:

Summary:

November 10, 2014

Mayo Clinic

The first steps in the origin of pancreatic cancer have been identified byresearchers who say that their findings suggest preventive strategies toexplore. The scientists described the molecular steps necessary foracinar cells in the pancreas -- the cells that release digestive enzymes -- to become precancerous lesions. Some of these lesions can thenmorph into cancer.

Share This

Related Topics

First steps in formation of pancreatic cancer identified

Save/Print: Share:

Breaking News:Remains of Ice Age Infants Found in Alaska

Email to a friend Facebook Twitter LinkedIn Google+ Print this page

Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins

Mobile: iPhone Android Web Follow: Facebook Twitter Google+ Subscribe: RSS Feeds Email Newsletters HEALTH PHYSICAL/TECH ENVIRONMENT SearchEnter keyword or phrase ...QUIRKYSOCIETY/EDUCATION

Mesothelioma Lung CancerSearch Mesothelioma Lung Cancer. Answer Your Health Questions Here

pdfcrowd.comopen in browser PRO version Are you a developer? Try out the HTML to PDF API

Credit: Image courtesy of Mayo Clinic [Click to enlarge image]

RRelated Articles

Shown is a region of a pancreas with preneoplastic lesions. Red labeling indicatesmacrophages, green labeling indicates pancreatic acinar cells that dedifferentiate,and grey labeling indicates further progressed pancreatic lesions.

esearchers at Mayo Clinic's campus in Jacksonville say they haveidentified first steps in the origin of pancreatic cancer and that theirfindings suggest preventive strategies to explore.

In an online issue of Cancer Discovery, the scientistsdescribed the molecular steps necessary for acinarcells in the pancreas -- the cells that release digestiveenzymes -- to become precancerous lesions. Some ofthese lesions can then morph into cancer.

"Pancreatic cancer develops from these lesions, so ifwe understand how these lesions come about, we maybe able to stop the cancer train altogether," says thestudy's lead investigator, Peter Storz, Ph.D., a cancerbiologist.

The need for new treatment and prevention strategies ispressing, Dr. Storz says. Pancreatic cancer is one of the most aggressive humancancers -- symptoms do not occur until the cancer is well advanced. One-year survivalafter diagnosis is only 20 percent. It is the fourth leading cause of cancer death in this

Related Topics

Health & Medicine

Related Stories

Microfluidic TechnologyReveals Potential Biomarkerfor Early Pancreatic CancerApr. 29, 2014 The detection ofpancreas cells in the blood may bean early sign of cancer, newresearch demonstrates. The findingssuggest that circulating pancreascells (CPCs) seed the bloodstream

before tumors ... full story

Origin of Inflammation-Driven PancreaticCancer DecodedAug. 5, 2013 Researchers have revealed theprocess by which chronic inflammation of thepancreas, pancreatitis, morphs into pancreaticcancer. They say their findings point to ways toidentify pancreatitis ... full story

Study Sheds Light on How PancreaticCancer BeginsNov. 29, 2012 Scientists examined the tumor-initiating events leading to pancreatic cancer (alsocalled pancreatic ductal adenocarcinoma or PDA) inmice. Their work may help in the search for earlierdetection ... full story

Link Between Inflammation and PancreaticCancer DiscoveredApr. 11, 2011 Solving part of a medical mystery,researchers have established a link betweenmolecules found in an inflamed pancreas and theearly formation of pancreatic cancer -- a discoverythat may help ... full story

Quality-of-Life Testing May PredictMalignancy and Survival in Patients With

DNA repairProstate cancerNecrosisCancerImmune systemCervical cancer

Pancreatic CancerCancerLymphomaSkin CancerBrain TumorProstate Cancer

pdfcrowd.comopen in browser PRO version Are you a developer? Try out the HTML to PDF API

MLA APA Chicago

country.

The scientists studied pancreatic cells with Kras genetic mutations. Kras produces aprotein that regulates cell division, and the gene is often mutated in many cancers.More than 95 percent of pancreatic cancer cases have a Kras mutation.

The researchers detailed the steps that led acinar cells with Kras mutations totransform into duct-like cells with stem cell-like properties. Stem cells, which candivide at will, are also often implicated in cancer.

They found that Kras proteins in the acinar cells induce the expression of a molecule,ICAM-1, which attracts macrophages, a specific kind of immune cells. Theseinflammatory macrophages release a variety of proteins, including some that loosenthe structure of the cells, allowing acinar cells to morph into different types of cells.These steps produced the precancerous pancreatic lesions.

"We show a direct link between Kras mutations and the inflammatory environment thatdrive the initiation of pancreatic cancer," Dr. Storz says.

But the process can be halted in laboratory mice, he adds. "We could do this twoways -- by depleting the macrophages or by treating the transformed cells with ablocking antibody that shuts down ICAM-1," says Dr. Storz. "Doing either one reducedthe number of precancerous lesions."

Dr. Storz noted that a neutralizing antibody that blocks ICAM-1has already beendeveloped. It is being tested for a wide variety of disorders, including stroke andrheumatoid arthritis.

"Understanding the crosstalk between acinar cells with Kras mutations and themicroenvironment of those cells is key to developing targeted strategies to prevent andtreat this cancer," he says.

Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials maybe edited for content and length.

Journal Reference:

1. G.-Y. Liou, H. Doppler, B. Necela, B. Edenfield, L. Zhang, D. W. Dawson, P. Storz.Mutant Kras-induced expression of ICAM-1 in pancreatic acinar cells causesattraction of macrophages to expedite the formation of precancerouslesions.. Cancer Discovery, 2014; DOI: 10.1158/2159-8290.CD-14-0474

Cite This Page:

Strange & Offbeat Stories

Malignancy and Survival in Patients WithPancreatic DiseaseMay 3, 2010 Quality-of-life measures usedroutinely to assess treatment outcomes for patientswith pancreatic disease may be used to predictboth malignancy and survival for those patients,according to a new ... full story

Pancreatic CancerSigns

lifescript.com

What is Pancreatic Cancer? Causes,Symptoms & Recovery.

Tissue cDNA Array

Health & Medicine

Mind & Brain

more related stories

Body Weight Heavily Influenced by Gut Microbes:Genes Shape Body Weight by Affecting GutMicrobes

Images of a Nearly Invisible MouseAll Kidding Aside: Medical Clowns Calm ChildrenDuring Uncomfortable Allergy Test

Having a Y Chromosome Doesn't Affect Women'sResponse to Sexual Images, Brain Study Shows

The Female Nose Always Knows: Do WomenHave More Olfactory Neurons?

Ghost Illusion Created in the LabFor Leaders, Looking Intelligent Is Less Important

pdfcrowd.comopen in browser PRO version Are you a developer? Try out the HTML to PDF API

More Health & Medicine News Monday, November 10, 2014

Mayo Clinic. "First steps in formation of pancreatic cancer identified."ScienceDaily. ScienceDaily, 10 November 2014..

Share This

Pancreatic CancerSigns

How To Tell If You HavePancreatic Cancer. Symptoms,

Causes, & More.

More From ScienceDaily

In Other News

Living & Well

... from NewsDaily.com

Science News

Health News

Email to a friend Facebook Twitter LinkedIn Google+ Print this page

Media consumption toaverage 15. 5 hours aday ...

Mystery sea of stars?Rocket experiment finds...

Astronomers solve puzzleabout bizarre object ...

Birth of planets revealedin astonishing ...

String field theory couldbe the foundation of ...

Universe may face adarker future: Is dark ...

Giant groundhog-likecreature: Newly ...

Scientists proposeexistence and interaction...

For Leaders, Looking Intelligent Is Less ImportantThan Looking Healthy

Direct Brain Interface Between HumansThis Just In: Political Correctness Pumps UpProductivity on the Job

Neuroscience of Choking Under Pressure: NewInsight

Sweet Music or Sour Notes? Test Will TellElection Day: The Saddest Day of the Year?Dance Choreography Improves Girls'Computational Skills

New Tech Aims to Improve CommunicationBetween Dogs, Humans

Liberal or Conservative? Reactions to Disgust Area Dead Giveaway

Robot 'dolphins' give clues to Antarctic melt indata revolution

Breakthrough Prizes in science, math earnwinners $3 million each

Three space station crewmen return safely toEarth in Kazakhstan

European comet mission gears up for tough probelanding

U.S. OKs genetically modified potato with lowercancer risk

New York doctor infected with Ebola to bereleased from hospital

Diabetes test strips likely overused among dualVA, Medicare patients

Docs should ask heart patients aboutsecondhand smoke: study

U.S. releases low 2015 Obamacare enrollmentforecast

pdfcrowd.comopen in browser PRO version Are you a developer? Try out the HTML to PDF API

Free Subscriptions Get Social & Mobile Have Feedback?

Featured Research from universities, journals, and other organizations

Featured Videos from AP, Reuters, AFP, and other news services

Find with keyword(s):

Search ScienceDaily

newer top stories | older top stories

Number of stories in archives: 140,361

Search

Enter a keyword or phrase to search ScienceDaily for related topicsand research stories.

Save/Print: Share:

Environment News

Technology News

Marijuana's Long-TermEffects on the BrainDemonstratedNov. 10, 2014 The effects ofchronic marijuana use on the brain

may depend on age of first use and duration of use,according to new research. Researchers for the firsttime comprehensively describe existing ... full story

Marijuana; Illegal Drugs; Controlled Substances;Intelligence

Marijuana's Long-Term Effects On the BrainNew Target for Blood Cancer Treatment DiscoveredStatins Reverse Some Learning Disabilities?Thousands of Newfound Human Genome VariationsBirthweight Charts Aimed at Ethnic Groups NeededClassification of Mutations in a Cancer May Help'Darting' Mice May Hold Clues to Neuro DiseasesViruses Like Ebola: Pre-Symptomatic Markers ID'dCombo Therapy for Quicker Eradication of Hep CFirst Steps in Formation of Pancreatic Cancer

The Best Apps ForYoga Enthusiasts

Laundry DetergentPods Harmful To Kids,Poison Control Warns

Ambulance DroneProvides SpeedyTreatment for CardiacArrest

New York City MightBe Next To RelaxMarijuana Rules

Merck expects no writedowns for Zetia, Vytorincholesterol drugs

Winter storm hits U.S. Plains, upper Midwest;cold to follow

Lava flow from volcano incinerates home onHawaii's Big Island

U.S. judge rejects BP bid to oust Gulf spill claimschief

Early snow falls on northern U.S., cold sweepingsouth

5.8-magnitude earthquake strikes northern Chile:USGS

Exclusive: Apple's enterprise assault gets intohigher gear

Obama pressures FCC for strong net neutralityrules

AT&T scraps plans for in-flight high-speed internetservice

Apple iOS bug makes devices vulnerable toattack: experts

Exclusive: Fullscreen to buy online video producerRooster Teeth

pdfcrowd.comopen in browser PRO version Are you a developer? Try out the HTML to PDF API

Get the latest science news with ScienceDaily's freeemail newsletters, updated daily and weekly. Or viewhourly updated newsfeeds in your RSS reader:

Keep up to date with the latest news from ScienceDailyvia social networks and mobile apps:

Tell us what you think of ScienceDaily -- wewelcome both positive and negative comments.Have any problems using the site? Questions?

About ScienceDaily | Editorial Staff | Awards & Reviews | Contribute | Advertise | Privacy Policy | Terms of UseCopyright 2014 by ScienceDaily, LLC or by third-party sources, where indicated. All rights controlled by their respective owners.

Content on this website is for informational purposes only. It is not intended to provide medical or other professional advice.Views expressed here do not necessarily reflect those of ScienceDaily, its staff, its contributors, or its partners.

Email Newsletters RSS Feeds

Facebook Twitter Google+

iPhone Android Web

Leave Feedback Contact Us