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Protein Synthesis Flip Book
By: Nick Constant
Cytoplasm
NucleusRibosomes
T A GC C T G T A C G T A TT
A T GG A CC A TT G C A AA
Cytoplasm
NucleusThe synthesis of messenger RNA is called transcription. This process begins when RNA polymerase binds to the promoter region on the double stranded DNA molecule.
T A GC C T G T A C G T A TT
A T GG A CC A TT G C A AA
Cytoplasm
Nucleus
RNA polymerase
The synthesis of messenger RNA is called transcription. This process begins when RNA polymerase binds to the promoter region on the double stranded DNA molecule.
T A GC C T G T A C G T A TT
A T GG A CC A TT G C A AA
Cytoplasm
Nucleus
RNA polymerase moves along the template strand of DNA as it breaks the hydrogen bonds and synthesizes the complementary single-stranded messenger RNA. As this is happening, the mRNA is formed, which later goes to the cytoplasm.
TA GC C T G T A C G T A TT
A T GG A CC A TT G C A AA
Cytoplasm
NucleusA
RNA polymerase moves along the template strand of DNA as it breaks the hydrogen bonds and synthesizes the complementary single-stranded messenger RNA. As this is happening, the mRNA is formed, which later goes to the cytoplasm.
T AGC C T G T A C G T A TT
A TGG A CC A TT G C A AA
Cytoplasm
NucleusAU
RNA polymerase moves along the template strand of DNA as it breaks the hydrogen bonds and synthesizes the complementary single-stranded messenger RNA. As this is happening, the mRNA is formed, which later goes to the cytoplasm.
T AG
CC T G T A C G T A TT
A TG
GA CC A TT G C A AA
Cytoplasm
NucleusAUG
RNA polymerase moves along the template strand of DNA as it breaks the hydrogen bonds and synthesizes the complementary single-stranded messenger RNA. As this is happening, the mRNA is formed, which later goes to the cytoplasm.
T AG
C CT G T A C G T A TT
A T GGA CC A TT G C A AA
Cytoplasm
NucleusAUGG
RNA polymerase moves along the template strand of DNA as it breaks the hydrogen bonds and synthesizes the complementary single-stranded messenger RNA. As this is happening, the mRNA is formed, which later goes to the cytoplasm.
T AG
C C TG T A C G T A TT
A T GG ACC A TT G C A AA
Cytoplasm
NucleusAUGGA
RNA polymerase moves along the template strand of DNA as it breaks the hydrogen bonds and synthesizes the complementary single-stranded messenger RNA. As this is happening, the mRNA is formed, which later goes to the cytoplasm.
T AG
C C T GT A C G T A TT
A T GG AC
CA TT G C A AA
Cytoplasm
NucleusAUGGAC
RNA polymerase moves along the template strand of DNA as it breaks the hydrogen bonds and synthesizes the complementary single-stranded messenger RNA. As this is happening, the mRNA is formed, which later goes to the cytoplasm.
T A GC C T GT A C G T A TT
A T GG A CCA TT G C A AA
CytoplasmNucleus
AUGGACC
RNA polymerase moves along the template strand of DNA as it breaks the hydrogen bonds and synthesizes the complementary single-stranded messenger RNA. As this is happening, the mRNA is formed, which later goes to the cytoplasm.
T A GC C T G TA C G T A TT
A T GG A CC ATT G C A AA
CytoplasmNucleus
AUGGACCA
RNA polymerase moves along the template strand of DNA as it breaks the hydrogen bonds and synthesizes the complementary single-stranded messenger RNA. As this is happening, the mRNA is formed, which later goes to the cytoplasm.
T A GC C T G T AC G T A TT
A T GG A CC AT
TG C A AA
CytoplasmNucleus
AUGGACCAU
RNA polymerase moves along the template strand of DNA as it breaks the hydrogen bonds and synthesizes the complementary single-stranded messenger RNA. As this is happening, the mRNA is formed, which later goes to the cytoplasm.
T A GC C T G T A CG T A TT
A T GG A CC AT
T GC A AA
CytoplasmNucleus
AUGGACCAUG
RNA polymerase moves along the template strand of DNA as it breaks the hydrogen bonds and synthesizes the complementary single-stranded messenger RNA. As this is happening, the mRNA is formed, which later goes to the cytoplasm.
T A GC C T G T A C GT A TT
A T GG A CC AT
T G CA AA
CytoplasmNucleus
AUGGA
CC
AUGC
RNA polymerase moves along the template strand of DNA as it breaks the hydrogen bonds and synthesizes the complementary single-stranded messenger RNA. As this is happening, the mRNA is formed, which later goes to the cytoplasm.
T A GC C T G T A C G TA TT
A T GG A CC AT
T G CA A
A
CytoplasmNucleus
AUGGA
CC
AUGCA
RNA polymerase moves along the template strand of DNA as it breaks the hydrogen bonds and synthesizes the complementary single-stranded messenger RNA. As this is happening, the mRNA is formed, which later goes to the cytoplasm.
T A GC C T G T A C G T ATT
A T GG A CC A TT G CA A
A
CytoplasmNucleus
AUGGA
CC
AUGCA
U
RNA polymerase moves along the template strand of DNA as it breaks the hydrogen bonds and synthesizes the complementary single-stranded messenger RNA. As this is happening, the mRNA is formed, which later goes to the cytoplasm.
T A GC C T G T A C G T AT
T
A T GG A CC A TT G C AA
A
CytoplasmNucleus
AUGGA
CC
AUGCA
UAA
RNA polymerase moves along the template strand of DNA as it breaks the hydrogen bonds and synthesizes the complementary single-stranded messenger RNA. As this is happening, the mRNA is formed, which later goes to the cytoplasm.
T A GC C T G T A C G T A TT
A T GG A CC A TT G C A AA
CytoplasmNucleus
AUGGA
CC
AUGCA
UAA
RNA polymerase moves along the template strand of DNA as it breaks the hydrogen bonds and synthesizes the complementary single-stranded messenger RNA. As this is happening, the mRNA is formed, which later goes to the cytoplasm.
T A GC C T G T A C G T A TT
A T GG A CC A TT G C A AA
CytoplasmNucleus
AU C
C
GG A
A U G C A UA
A Ribosome
The mRNA leaves out of the nuclear pore and meets up with a ribosome
T A GC C T G T A C G T A TT
A T GG A CC A TT G C A AA
Cytoplasm
AU C
C
GG A
A U G C A UA
A
Nuclear Pore
Ribosome
The mRNA leaves out of the nuclear pore and meets up with a ribosome
T A GC C T G T A C G T A TT
A T GG A CC A TT G C A AA
Cytoplasm
AU C
C
GG A
A U G C A UA
A
Nuclear Pore
Ribosome
The mRNA leaves out of the nuclear pore and meets up with a ribosome
T A GC C T G T A C G T A TT
A T GG A CC A TT G C A AA
Cytoplasm
AU C
C
GG A
A U G C A UA
A
Nuclear Pore
Ribosome
The mRNA leaves out of the nuclear pore and meets up with a ribosome
T A GC C T G T A C G T A TT
A T GG A CC A TT G C A AA
Cytoplasm
AU C
C
GG A
A U G C A UA
A
Nuclear Pore
Ribosome
The mRNA leaves out of the nuclear pore and meets up with a ribosome
T A GC C T G T A C G T A TT
A T GG A CC A TT G C A AA
Cytoplasm
AU C
C
GG A
A U G C A UA
A
Nuclear Pore
Ribosome
The mRNA leaves out of the nuclear pore and meets up with a ribosome
T A GC C T G T A C G T A TT
A T GG A CC A TT G C A AA
Cytoplasm
AU C
C
GG A
A U G C A UA
A
Nuclear Pore
Ribosome
The mRNA leaves out of the nuclear pore and meets up with a ribosome
T A GC C T G T A C G T A TT
A T GG A CC A TT G C A AA
Cytoplasm
AU
C CGG A
A UG
CA U
AA
Nuclear Pore
Ribosome
The mRNA leaves out of the nuclear pore and meets up with a ribosome
T A GC C T G T A C G T A TT
A T GG A CC A TT G C A AA
Cytoplasm
AU
C CGG
A AU
GC
AU A A
Nuclear Pore
Ribosome
The mRNA leaves out of the nuclear pore and meets up with a ribosome
T A GC C T G T A C G T A TT
A T GG A CC A TT G C A AA
Cytoplasm
Nuclear Pore
NucleusA
UC
C
GG
A
AU
GC
AU
AA
Ribosome
mRNA
The mRNA leaves out of the nuclear pore and meets up with a ribosome
A T GG A CC A TT G C A AAT A GC C T G T A C G T A TT
Cytoplasm
Nuclear Pore
NucleusA
UC
C
GG
A
AU
GC
AU
AA
Ribosome
mRNA
The mRNA leaves out of the nuclear pore and meets up with a ribosome
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
U A C
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
U A C
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
U A C
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
U A C
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
U A C
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
U A C
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
U A C
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
U A C
UC G
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
U A C
UC G
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
U A C UC G
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U GU A C
UC G
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
U A C
UC G
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
U A C
UC G
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
UC G
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
UC G
UG A
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
UC G
UG A
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
UC G
UG A
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
UC G
UG A
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
UC G UG A
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
UC G UG A
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
UC G
UG A
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
UC G
UG A
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
UC G
UG A
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
UC G
UG A
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
UC G
UG A
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
UG A
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
UGC
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
UGC
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
UGC
mRNA
GUA CG A C A U G C A U AA
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Ribosome
A C
U G
UGC
mRNA
GUA CG A C A U G C A U AA
UGC
Key:
- Adenine - Cytosine
- Uracil - Guanine
- Large Unit - Small Unit
- Ribosome
A C
U G
mRNA
GUA CG A C A U G C A U AA
Peptide Bonds
This is the polypeptide chain that is formed. It folded into its final conformation, was completed and then released.
Protein Synthesis Summary
• The first step in the production of proteins is called transcription. This occurs on the inside of the nucleus inside of the cell. DNA is stored as a double helix inside of the nucleus. What transcription does, is that it copies the DNA sequence of a gene and then takes it to the cytoplasm of a cell. To start transcription, RNA polymerase binds to the start of the gene. From there on, the complementary RNA strand is synthesized. RNA polymerase unravels and copies one side of the double helix, and breaks the hydrogen bonds between the bases as it moves along. The strand of DNA acts as a template for the second generation of a second identical strand. This copy is made of RNA.
Protein Synthesis Summary
• After transcription happens, translation occurs. It is the process of converting the nucleotide sequence of an mRNA molecule. It does this so a protein-making machinery can understand it. After the mRNA copy leaves the nucleus through the nuclear pore and into the cytoplasm, it comes into contact with ribosomes. Ribosomes are made up into a large subunit and a small subunit. Ribosomes translate the mRNA code from the DNA template into an amino acid sequence that makes up a protein. During translation, a small ribosomal subunit attaches to a mRNA molecule. While this is happening, an initial tRNA molecule binds to a specific codon sequence on the same mRNA molecule.
Protein Synthesis Summary
• After that, a large ribosomal subunit joins the complex. When a new tRNA molecule recognizes the next sequence in the mRNA, it attaches itself. This forms a peptide bond between the two amino acids. This continues until the final polypeptide chain is formed.