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Food and Drug Food and Drug InteractionsInteractions
Khalid A. Al-Madani, MPH, DScConsultant In Clinical Nutrition & Vice Present
of Saudi Society for Food and Nutrition
Medications and Food Intake
Drug Complications That Alter Food Intake
Medications and Food Intake
(Conti.)
Medication That Alter Appetite
Diet-Drug Interactions and Absorption
Medication Effectson Nutrient Absorption
Drug-nutrient binding
Diet-Drug Interactions and Absorption (Conti.)
Diet-Drug Interactions and Absorption (Conti.)
Altered acidity in thestomach
Stomach Emptying Rate
Diet-Drug Interactions and Absorption (Conti.)
Diet-Drug Interactionsand Metabolism
An An increaseincrease leads to a leads to a decreasedecrease
in enzyme activityin enzyme activity in drug concentration in drug concentration
and effect and effect
ANDAND
A A decreasedecrease leads to an leads to an increaseincrease
in enzyme activityin enzyme activity in drug concentration in drug concentration
and effect and effect
Diet-Drug Interactionsand Metabolism ( Conti.)
Diet-Drug Interactionsand Metabolism ( Conti.)
A New Concern - A New Concern - GrapefruitGrapefruit
Can cause more Can cause more of a drug to be of a drug to be absorbed from absorbed from intestine – even intestine – even toxic levelstoxic levels
May cause a May cause a drug not to drug not to workwork
Diet-Drug Interactionsand Metabolism ( Conti.)
Diet-Drug Interactionsand Metabolism ( Conti.)Vitamin K and WarfarinVitamin K and Warfarin
Keep intake of foods containing Keep intake of foods containing Vitamin K constantVitamin K constant
Vitamin K is high in spinach, kale, Vitamin K is high in spinach, kale, cauliflower, broccoli and other cauliflower, broccoli and other leafy greensleafy greens
Also don’t take Vitamin K Also don’t take Vitamin K
supplementsupplement
Diet-Drug Interactionsand Excretion
Medication Effects onNutrient Excretion
Diet-Drug Interactionsand Excretion ( Conti.)
Dietary Effects onMedication Excretion
Diet-Drug Interactionsand Toxicity
Diet-Drug Interactionsand Toxicity ( Conti.)
MOA Inhibitors MOA Inhibitors No beer, red wine No beer, red wine No cheddar, brie, No cheddar, brie,
mozzarella cheesemozzarella cheese No beef or chicken liver, No beef or chicken liver,
cured meats, caviar or dried cured meats, caviar or dried fishfish
Diet-Drug Interactionsand Toxicity ( Conti.)
Conclusion
Clinicians often overlook or fail to recognize diet-drug interactions, yet such interactions can raise health care costs and result in serious, and sometimes fatal, complications. With hundreds of diet-drug interactions known and more to be identified in the future, health care professionals must learn to take steps to prevent them.
THANK YOUTHANK YOU
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