For Financial Professional Use OnlyConfidential Information Enclosed
For Financial Professional Use Only
Strategy• Designed to outperform broad market exposure by investing in growth equities leveraging proprietary primary research
• Science-driven biotechnology and pharmaceutical companies addressing high unmet medical needs are emphasized
Experienced Team
• Award winning scientists who have transitioned to successful professional investors..
• Lead Portfolio Manager Mark G. Charest, Ph.D. has a distinguished scientific background and more than a decade of institutional
healthcare investing experience
• More than a decade of collaboration experience working with LifeSci Partners
LifeSci Platform
• Since 2009, LifeSci Partners has been a leading provider of strategic scientific consulting services for innovative healthcare
companies
• Global presence with more than 100 investment and science professionals including 20+ Ph.D.s and MDs
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Leveraging the experience of 20+ PHDs and MDs and the hands on scientific achievements of Mark Charest to invest in Biotech
and Healthcare equities with the objective of seeking long-term capital appreciation.
Avoiding fad story stocks to focus on smaller companies with truly advanced scientific breakthroughs and value priced larger cap
stocks.
For Financial Professional Use Only
Healthcare is a Leading Global Industry Segment with Robust Secular Growth
Global healthcare spending
exceeded $8 trillion in 2018
with ~$600 billion biopharma
spend
Robust Innovation ecosystem
Unprecedented science- and technology- driven
innovation developing paradigm shifting technology
Constructive Regulatory Environment
Sustained pace of FDA approval for innovative new
products, new regulatory initiatives streamlining process
Healthy Capital Markets
Strong financing environment providing ample capital to
fund innovation, continued pace of M&A
3
Secular drivers: growing
population, increasing life
expectancy, demographic
shift and expanding access
Healthcare Sector Fundamentals Pharmaceutical Investment Landscape Tailwinds
*Source: Deloitte 2019 Healthcare Outlook
Global health care spending
is projected to increase at an
annual rate of 5.4% in 2018–
2022, outpacing GDP growth
For Financial Professional Use Only
Epilepsy2%
Ophthalmology4%
GI/Ulcer5%
Multiple Sclerosis5%
Hepatitis5%
Respiratory 5%
CNS6%
Rheumatology8%
Diabetes/Obesity10%
Cardiology 10%
Infectious Disease15%
Cancer/Onc/Hem. 25%
Biopharmaceuticals is an attractive global growth sector
Therapeutic Categories: Drug sales as a percentage of the total market
*Source: February 2019 Cowen & Company Therapeutic Categories Outlook
**Source: March 2019 Cowen Pharmaceutical Industry Pulse branded drug prices expected to increase 3-6% annually over next 3 years
$569B
2018
Orphan Diseases4%
Ophthalmology2%
GI/Ulcer4%
Multiple Sclerosis5%
Dermatology5%
Respiratory 5%
CNS5%
Rheumatology7%
Diabetes/Obesity10%Cardiology
8%
Infectious Disease15%
Cancer/Onc/Hem. 30%
$688B
2021P
Biopharmaceutical market
$569B in 2018 and projected to grow
>5% annually over the next five
years*
Growth projections supported by
attractive R&D pipelines, specifically
in oncology and orphan diseases*
Stable pricing outlook maintained
despite ‘noise’ from US Healthcare
reform**
Upside from increasing demand in
China and other developing countries
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For Financial Professional Use Only
Fund Portfolio Manager
Mark G. Charest, Ph.D. I Portfolio Manager
Mark is an inventor on 8 drug patents who also has a successful career as a healthcare investor at several specialized $1B+ AUM healthcare
technology funds. He led a Medicinal Chemistry Lab at the Novartis Institutes for BioMedical Research after earning his Ph.D. in chemistry and
chemical biology from Harvard University. He is a National Science Foundation Graduate Research Fellow, with an MS in chemistry and chemical
biology from Harvard University. His distinguished career includes the completion of noble prize winning chemist RB Woodward’s work on chemical
synthesis of tetracycline. This work was critical in the creation of an approved drug to treat complicated intra-abdominal infections. After
successfully running a lab at Novartis which included successfully putting a drug into clinical trials. Mark transitioned to Wall Street in 2007. He has
held positions as an SVP at Tekla Capital Management, a Portfolio Manager at New Leaf Venture Partners and an Associate at Great Point Partners.
Mark was a Kauffman Fellow at Panorama Capital where he served on the board of directors of Itero Biopharmaceuticals and was a board observer
at Presidio Pharmaceuticals and PowerVision.
Patents
“Synthesis of Tetracyclines and Analogues Thereof.” Andrew G. Myers, Mark G. Charest, Christian D. Lerner, Jason D. Bruaker and Dionicio R. Siegel, U.S. Patent 8,598,148;
December 3, 2013 and U.S. Patent 9,365,493; June 14, 2016.
“Inhibitors of IAP.” Mark G. Palermo, Sushil K. Sharma, Christopher Straub, Run-Ming Wang, Leigh S. Zawel, Yanlin Zhang, Zhuoliang Chen, Yaping Wang, Fan Yang, Wojciech Wrona,
Gang Liu, Mark G. Charest and Feng He, U.S. Patent 8,338,440; December 25, 2012 and U.S. Patent 8,207,183; June 26, 2012.
“Pyrrolydine Derivatives as IAP Inhibitors.” Mark G. Charest, Christine Hiu-Ting Chen, Ming Chen, Miao Dai, Feng He, Huangshu Lei, Christopher Straub, Run-Ming Wang, and Leigh S.
Zawel, U.S. Patent 8,044,209; October 25, 2011.
“Synthesis of Tetracyclines and Analogues Thereof.” Andrew G. Myers, Mark G. Charest, Christian D. Lerner, Jason D. Bruaker and Dionicio R. Siegel, U.S. Patent 7,807,842; October
5, 2010.
“Organic Compounds.” Mark G. Palermo, Sushil K. Sharma, Christopher Straub, Run-Ming Wang, Leigh S. Zawel, Yanlin Zhang, Zhuoliang Chen, Yaping Wang, Fan Yang, Wojciech
Wrona, Gang Liu, Mark G. Charest and Feng He, U.S. Patent 7,419,975; September 2, 2008.
“Preparation of α-Hydroxy-γ-[[(carbocyclic- or heterocyclic-substituted)amino]carbonyl]-alkanamides as HIV Protease Inhibitors.” James R. Tata, Zhijian Lu, Subharekha Raghavan,
Tracy T. Huening, Thomas A. Rano and Mark G. Charest, U.S. Patent 6,589,962; July 8, 2003.
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For Financial Professional Use Only
LifeSci Partners Leadership
Andrew McDonald, Ph.D. I Founding PartnerAndrew co-founded LifeSci Partners in 2009 which has since grown to employ 100+ healthcare professionals offering a broad range of advisory
services to more than 150 corporate clients in the life sciences sector. As a scientist and former equity analyst, Andrew has a strong understanding
of transformative pharmaceutical products and also has a strong network across healthcare institutional investors and executives. Prior to LifeSci,
Andrew worked at Great Point Partners, a life sciences hedge fund, and headed healthcare research and was a publishing biotechnology analyst
at ThinkEquity Partners. Prior to entering the financial services industry, Andrew was a medicinal chemist at Cytokinetics and at Pfizer.
Mike Rice I Founding PartnerMichael Rice has experience in portfolio management, corporate management, investment banking and capital markets. Prior to co-founding
LifeSci Partners, Michael was the co-head of health care investment banking at Canaccord Adams, where he was involved in debt and equity
financing. Michael was also was a Managing Director at ThinkEquity Partners where he was responsible for managing Healthcare Capital Markets,
which included structuring and executing numerous transactions, many of which were firsts at ThinkEquity. Prior to that, Michael served as a
Managing Director at Banc of America serving large hedge funds and private equity healthcare funds.
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For Financial Professional Use Only
LifeSci Partners
Who We Are
LifeSci Partners is the leading provider of strategic
scientific consulting services in the areas of investor
relations, public relations, corporate communications,
executive search and capital markets advisory.
Combining deep domain expertise in the life sciences
with decades of experience in capital markets and
corporate communications, LifeSci Partners delivers
unparalleled services to life sciences companies globally.
With global presences in New York, Chicago, Boston,
London, Geneva, Paris, Asia and Tel-Aviv, LifeSci
Advisors leverages its relationships and local knowledge
in multiple territories around the world to provide high
value services for clients.
LifeSci
Advisors
LifeSci
Public Relations
LifeSci
Capital
LifeSci
Venture
LifeSci
Search
LifeSci
Partnering & Analytics
6
For Financial Professional Use Only 8
LifeSci Partners Operating Companies
Built on deep domain expertise in the life sciences
LifeSci Advisors
Comprehensive investor
relations, customized
marketing communications,
and strategic counsel
LifeSci Public Relations
Expert public and media
relations support and
strategic corporate
communications counsel
LifeSci Search
Global executive
recruitment specializing in
C-Suite and board
placements for the
healthcare industry
LifeSci Capital
(member FINRA/SIPC):
Investment banking services
including equity and debt
issuance
LifeSci Venture Partners
LifeSci Venture Partners I
launched in 2017 and co-
investment vehicles have
deployed $35mm into 12
companies
BioShares ETFs
Leading biotechnology
exchange traded funds
(NYSE: BBC & BBP)
+Newly created, independent
division led by Mark
Charest, Ph.D. to manage
the fund. Compliance
program to be implemented
for conflict management.
LifeSci Fund Management
For Financial Professional Use Only
LifeSci Capital Research Team
Highlights
11 Person Research Team
Deep Scientific Knowledge
with 4 Ph.D.’s on research
team, 20+ across LifeSci
Partners
Domain Expertise in key thematic healthcare areas
including: Oncology/Hematology/Infectious
Disease/Neurodegenerative diseases/ Autoimmune
disorders/Endocrinology/Genetic & Rare
diseases/Gastroenterology/Ophthalmology
Surveys & Statistical Analysis
Understanding key healthcare market dynamics
Primary sourcing for physician/patient dynamics
Events
Host KOL dinners at every major medical conference
Live webcasted KOL calls and corporate access events
Research Publications
540 publications in 2018 with 95 companies under
coverage
Alpha series- deep fundamental research on high
conviction companies in the healthcare space which
includes multiple conversations with leading KOL experts
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For Financial Professional Use Only
Healthcare Sector Overview
For Financial Professional Use Only
Fund Strategy Driven by Proprietary Primary Research
Healthcare Company
Universe>500 companies with
aggregate market
capitalization >$1 trillion
Universe Mapping
Systematically screen
corporate universe using
proprietary fundamental
scientific and financial analysis
Thematic Areas of FocusSector diligence and
KOLs input to identify
highly innovative
thematic areas of interest
Thesis Driven Stock SelectionComprehensive fundamental
analysis using proprietary
diligence methodology
Portfolio Construction
Thesis-driven price targets for entry
and exit points. Relative risk / reward
analysis determines position size and
subsector exposure
Ongoing Diligence
Regular contact with
management teams and KOL
community to validate ideas
Portfolio Management
Systematic monitoring of
market action against price and
exposure targets
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For Financial Professional Use Only
Representative Investments
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*Source: Deloitte 2019 Healthcare Outlook
Lead or participant in transformative financing to unlock latent value (Recap, PIPE, IPO, etc.)
For Financial Professional Use Only
Constructive Regulatory Environment
FDA Approvals*
*Source: FDA Novel Drugs Summary 2018
**Source: 2018 CDER Update for Rare Diseases (Note: Expedited development timeline typically <6 years vs 10+ for traditional programs)
Expedited ProgramsBreakthrough
N = 30
Fast Track
N = 105
Priority
N = 146
Accelerated
Approval N = 34
Rare (N = 113) 19% 55% 77% 27%
Oncology 28% 58% 84% 48%
Non-Oncology 13% 52% 71% 11%
Non-Rare (N = 195) 4% 22% 30% 2%
Oncology 11% 42% 68% 11%
Non-Oncology 3% 20% 26% 1%
Expedited Clinical Development ProgramsCDER NME approvals 2008 - 2016
1824 26
21
30
39
27
4145
22
46
59
35 34 36
23
41 4136
4135
41
57
43
0
10
20
30
40
50
60
70
2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018
NME/BLA Approvals NME/BLA Filings
CDER New Molecular Entity (NME) and New Biologic License
Application (BLA) Filings and Approvals
• Steady stream of applications with some variation on approval rate
• Targeted therapies have grown from 5% of approvals in 1990s to >45% in recent years
• Programs implemented to expedite development/approval and provide additional incentives in areas of high unmet need**
− Breakthrough Therapy Designation, Priority Review, Accelerated Approval, Priority Review Voucher, etc.
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For Financial Professional Use Only
Significant Increase in FDA Approval Rates
FDA Continues to improve regulatory process
*Source: FDA Novel Drugs Summary 2018
**Source: 2018 CDER Update for Rare Diseases (Note: Expedited development timeline typically <6 years vs 10+ for traditional programs)
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Pre-1992
1992-2007
2007-2012
2012+
For Financial Professional Use Only
Ongoing M&A Demand
*Source: MergerMarket Pharma, Medical and Biotech Trend report 2016
Ongoing M&A demand*
>$1.9 trillion in aggregate healthcare M&A from
financial crisis through 2016
Biopharmaceutical deal count increasing since
financial crisis
Median deal value >$500M
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For Financial Professional Use Only
High standard deviation of returns in biopharma provides opportunity
*Source: LifeSci VC Biotech IPOs: Outliers, Value Creation, and the Dispersion of Returns. Dispersion analysis from 2014 with all companies with Mcap >$200M. IPOs include n=159 companies trading through the end of 2016 that had not been
acquired or shutdown.
22% 24% 27% 29% 31%37% 37% 39% 40%
55%
32% 32%
56%61% 62%
91%
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
Biopharmaceutical return dispersions*Biopharma had the highest return dispersions of any sector in 2014
Trend holds for the decade 2005-2014 as well
By Sector* First Year IPO’s Only **
Dispersion Comparison By Industry and for Recent IPOsAverage Standard Deviation of 12-Month Returns
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For Financial Professional Use Only
Executive Summary
Fund
• AlphaCentric LifeSci Heathcare Fund invests in healthcare securities
• May invest in IPOs and mezzanine financing offerings
• Fund's objective is to provide long-term capital appreciation through fundamental, thesis-driven investments
Team• Portfolio Manager Mark G. Charest, Ph.D. has more than a decade of institutional healthcare investing experience
• More than a decade of collaboration experience working with LifeSci Partners
Global Platform
• Since 2009, LifeSci Partners has been a leading provider of strategic scientific consulting services in the areas of investor
relations, public relations, corporate communications, executive search, and capital markets advisory
• Experienced 100+ investment and science professionals including 20+ Ph.D.s and MDs in New York City, Boston, Philadelphia,
London, Geneva, Paris and Tel Aviv.
Access• LifeSci Partners reach across all areas of healthcare industry brings unique insights and capabilities
• LifeSci’s 12-person research team, scientific advisory board, and KOL network
Strategy• Proprietary primary research is utilized to select companies believed to have significant growth potential
• Science-driven biotechnology and pharmaceutical companies addressing high unmet medical needs are emphasized
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For Financial Professional Use Only
IMPORTANT RISK CONSIDERATIONS Investors should carefully consider the investment objectives, risks, charges and expenses of the AlphaCentric Funds. This and other important information about the
Fund is contained in the prospectus, which can be obtained by calling 844-ACFUNDS (844-223-8637) or at www.AlphaCentricFunds.com. The prospectus should be
read carefully before investing. The AlphaCentric Funds are distributed by Northern Lights Distributors, LLC, member FINRAISIPC. AlphaCentric Advisors LLC is not
affiliated with Northern Lights Distributors, LLC.
This presentation is prepared for internal communications only and shall not constitute an offer to sell or the solicitation of any offer to buy which may only be made at
the time registration statement is filed. These securities shall not be offered or sold in any jurisdiction in which such offer, solicitation or sale would be unlawful until the
requirements of the laws of such jurisdiction have been satisfied. While all the information prepared in this presentation is believed to be accurate, LifeSci Partners
(collectively all LifeSci branded entities such as LifeSci Advisors, LLC, LifeSci Capital, LLC, etc.) and/or Phenomic Capital LLC (Phenomic) make no express warranty as
to the completeness or accuracy nor can they accept responsibility for errors appearing in this presentation. Any projections, outlooks or assumptions should not be
construed to be indicative of the actual events which will occur. This presentation is not intended for public use or distribution. Phenomic and LifeSci Partners are
furnishing this presentation on a confidential basis. These materials may not be reproduced, either whole or in part, nor may the contents be disclosed to any third party.
The information provided herein, including, without limitation, investment strategies, investment restrictions and parameters, may be modified, terminated or
supplemented at any time without further notice in a manner which LifeSci Partners and/or Phenomic believe is consistent with its overall investment objective.
The Fund is a new mutual fund and has a limited history of operations for investors to evaluate. The fund may be non-diversified and the value and/or volatility of a single
issuer could have a greater impact on fund performance. The Fund may be susceptible to an increased risk of loss due to adverse occurrences affecting the Fund more
than the market as a whole, because the Funds investments are concentrated. Some securities held by the Fund may be difficult to sell, or illiquid, particularly during
times of market turmoil. The Funds' can invest in smaller-sized companies which may experience higher failure rates than larger companies and normally have a lower
trading volume than larger companies. The funds' can have risk associated with the biotechnology and pharmaceutical industry in which these companies may be
heavily dependent on clinical trials with uncertain outcomes and decisions by the U.S. Food and Drug Administration. Companies in the technology industries have
different risks including, but not limited to, products becoming obsolete, and entrance of competing products. Further, these companies are dependent on patent
protection, and the expiration of patents may adversely affect the profitability of the companies. The Fund invests in IPOs at the time of the initial public offering and in
post-IPO trading. IPOs are often subject to extreme price volatility and speculative trading. The ETFs in which the fund invests are subject to advisory fees and other
expenses and as a result the cost of investing in the fund will be higher than the cost of investing directly in the underlying funds. The Funds can have risk related to
option investing. There are special risks associated with investments in foreign companies including exposure to currency fluctuations, less efficient trading markets,
political instability and differing auditing and legal standards. All investments involve risks, including possible loss of principal, there is no assurance that the Fund will
achieve its investment objective
7321-NLD-12/5/2019
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