DROPLET GENERATION USING MICROFLUIDIC SYSTEM

Presented by:• Praveen Kumar (IBM2012011)• Suravi Srivastava (IBM2012014)• Saurabh Shivalkar (IBM2012022)• Divakar Badal (IBM2012031)• Amar Dhwaj (IBM2012035)• Mehul Agrawal (IBM2012036)

Under Guidance: Dr. Amit Prabhakar

Mid-Sem Project Evalualtionon

INTRODUCTION

What is Micro-Fluidic system ? Where do we need them ?

400/100 T- junction having flow rate of 15microlt /minTripathi S., Prabhakar A., Kumar N., Sing G.S. and Agarwal A ., ‘Blood plasma separation in elevated dimension T-shaped microchannel ‘ , Biomed microdevices , springer2013

Problem Statement & Objective

• To build a cheaper microfluidic device for the generation of droplets on the simulated geometry of T & Y-junction.

Literature review• Mattias Björnmalm, Yan Yan, Frank Caruso,’Engineering and evaluating drug delivery

particles in microfluidic devices’, Journal of Controlled Release, elsevier,2014• Linas Mazutis, John Gilbert, W Lloyd Ung, David A Weitz, Andrew D Griffiths & John A

Heyman,’ Single-cell analysis and sorting using droplet-based microfluidics’,Nature protocal 2013:

• Zhao-Miao Liu, Li-Kun Liu and Feng Shen,’Effects of geometric configuration on droplet generation in Y-junctions and anti-Y-junctions microchannels’, Acta Mech. Sin.,Springer, Aug2015

Simulation Parameters

Assumptions : 1) Noslip Boundry Conditions.2) Laminar Fluid Flow3) Incompressable Fluids 4) Uniform Pressure Distribution5) Immiscible Fluids 6) Solid boundaries represent a wetted wall with a contact angle of 135 degrees .

Worked So far:

At Flow rate : 0.4ml/min Continuous Fluid 0.4ml/min Dispersion FluidFor Duration: 0:0.005:0.08 sec

Average droplet diameter:T-junction : 0.107948 mmY-junction : 0.116021 mm

Contd...

At Flow rate : 0.4ml/min Continuous Fluid 0.2ml/min Dispersion FluidFor Duration: 0:0.005:0.08 sec

Average droplet diameter:T-junction : 0.077978 mmY-junction : 0.091834 mm

Contd...

At Flow rate : 0.3ml/min Continuous Fluid 0.1ml/min Dispersion FluidFor Duration: 0:0.005:0.08 sec

Average droplet diameter:T-junction : 0.072818 mmY-junction : 0.065366 mm

Contd...

At Flow rate : 0.4ml/min Continuous Fluid 0.1ml/min Dispersion FluidFor Duration: 0:0.005:0.08 sec

Average droplet diameter:T-junction : 0.043542 mmY-junction : 0.061932 mm

Plotted droplet diameters

Slide

Gravitational Syringe Pump

Syringe Pump

Motor driven pump

Result

Future scope

• Using such master slides, cheaper design testing can be achieve.

• Verified designs can be rebuild using standard protocols.

Thank you

References

• Mattias Björnmalm, Yan Yan, Frank Caruso,’Engineering and evaluating drug delivery particles in microfluidic devices’, Journal of Controlled Release, elsevier,2014

• Linas Mazutis, John Gilbert, W Lloyd Ung, David A Weitz, Andrew D Griffiths & John A Heyman,’ Single-cell analysis and sorting using droplet-based microfluidics’,Nature protocal 2013:

• Zhao-Miao Liu, Li-Kun Liu and Feng Shen,’Effects of geometric configuration on droplet generation in Y-junctions and anti-Y-junctions microchannels’, Acta Mech. Sin.,Springer, Aug2015

• Comsol user manual https://www.comsol.co.in/model/download/220831/models.cfd.droplet_breakup.pdf