VOLUME 265. NUMBER 3. JUNE 1993

JPETAB 265 (3) 1039-i 567 (1993)

ISSN 0022-3565

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The Journal of

PHARMACOLOGYAND EXPERIMENTAL THERAPEUTICS

A Publication of The American Society

for Pharmacology and Experimental TherapeuticsFounded by John J. Abel-1909

Edited for the Society by John A. Harvey

Published by Williams & Wilkins

COPYRIGHT © 1993 BY THE AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

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The Editor of The Journal of Pharmacology and Experimental Therapeutics wishes to express appreciation to the following

colleagues who acted as Guest Editors for Specific Fields in 1992.

Martin W. AdlerEdson X. AlbuquerqueLewis AronowCarl K. BucknerMarie Francoise ChesseletTheodore J. CiceroDavid E. ClarkeMarlene L. CohenMax CostaCharles R. CraigStephen K. Fisher

Alan FrazerRay W. FullerGerald L. Gebber

Stephen G. HoltzmanE. H. Jeffrey

Kenneth Johnson

Rudolph L. JulianoDavid D. KuJohn S. LazoIrwin LuckiDonald E. McMillan

Lawrence MiddaughWilliam H. Morse

David L. NelsonSaul M. SchanbergKenneth J. Simansky

Roger D. SpealmanJack W. StrandhoyBoris TabakoffR. Clinton WebbMichael Williams

Additionally, sincere thanks are due to 1060 of our colleagues not on the Editorial Advisory Board who reviewed articles for the

Journal in 1992. Their contributions are acknowledged individually in the Annual Report of The Journal to The Board ofPublications Trustees of The American Society for Pharmacology and Experimental Therapeutics.

INDEX

Volume 265, April-June, 1993

A231877, endothelium-dependent relaxa-

tion of aorta, L- and D-enantiomers,NG�nitro�arginine (rats), 112

Abe, Y., Kitada, Y. and Narimatsu, A.: Ef-fect of MCI-154, a cardiotonic agent,on regional contractile function andmyocardial oxygen consumption in

the presence and absence of coronaryartery stenosis in dogs, 819

Abreu, M. E., see Clissold, D. B., 876Abreu, M. E., see Karbon, E. W., 866Absence, precipitated

chronic diazepam (dogs), 1152concentration-response curves, opiate-dc-

pendent ileum (guinea pigs), 1519Acetylcholine

cholinergic interaction, atpha-2 adreno-

ceptor-mediated antinociception(sheep), 536

effects of lemakalim, comparison of vaso-dilators (dogs), 1026

endothelium-dependent relaxation ofaorta, L- and D-enantiomers, N’-ni-tro-arginine (rats), 112

extracellularincreased levels, sigma ligands in fron-

tal cortex (rats), 851microdialysis, 1,2,3,4-tetrahydro-9-

aminoacridine, striatum (rats), 759

pharmacological characterization, reno-

vascular P2 purinergic receptors(rats), 334

receptors and nicotinic binding sites,neuroblastoma clone line (humans),294

responses of circular myometrium, pro-gesterone and mifepristone, oxytocin(rats), 1205

N-Acetylcysteine, inhibition of angiotensin

converting enzyme (rats), 1239

N-Acetyl fl-endorphin(1-31), substance Pand, supraspinal antinociception, muopioid and alpha-2 adrenoceptors(mice), 835

N-Acetyl-neurotensin(8-13), inhibition ofvascular leakage, tissue injury (rats),619

Acetylsalicylic acid, airway smooth musclefunction during development, Bay K

8644 and CGP 28392 (guinea pigs),

524Acid, secretion reduction by L-365,260, pre-

vention of gastrointestinal damage,aspirin/ethanol/cysteamine (rats),1348

Acidosis, extracellular, cell death, renal

proximal tubules (rabbits), 1355Ackerman, J. M., Johansen, P. A., Clark, D.

and White, F. J.: Electrophysiologicaleffects of putative autoreceptor-se-lective dopamine agonists on AlO do-pamine neurons, 963

Action potential, duration, minoxidil sul-fate-induced shortening, ionic mech-

anisms in myocytes (guinea pigs),

1527

Acylcarnitines, long-chain, permeability

and morphology, colonic mucosa(rats), 955

AD-5423, haloperidol and, pharmacologicalactivities, antipsychotic efficacy and/

or adverse side effects (rats), 745

Adenine, pharmacological characterizationof N-0840, 227

Adenosine

agonists, ventilation effects (monkeys),971

Al-selective agonist RG14202 (pigs), 699

effects of lemakalim, comparison of vaso-dilators (dogs), 1026

metabolite, inhibition, proliferation of

nontransformed cells (mice), 790

Adenosine triphosphatase, inhibitors, inhi-

bition of relaxation, nitroglycerin

and atrial natriuretic factor (rabbits),1187

Adenosine triphosphate

P2 purinergic receptorshuman breast tumor cells, 1499

pharmacological characterization, re-

novasculature (rats), 334

-sensitive potassium channel

action potential durations, minoxidil

sulfate-induced shortening (guinea

pigs), 1527

blocker glyburide, natriuretic proper-ties (rats), 933

cardioprotection with zofenopril, myo-

cardial ischemia (rats), 609

no abolishment of preconditioning, is-

chemic heart (rats), 559relaxation of coronary arteries, calci-

tonin gene-related peptide (pigs), 490

Adenylate cyclase, short-term desensitiza-

tion, muscarinic m2 receptors, cere-

bellar granule cells (rats), 433Adipocytes, lipolytic responses, desensiti-

zation, beta-i and beta-2 adrenocep-

tors (hamsters), 237

Adrenal gland, pharmacological character-ization, SR 47436 (rats, dogs, mon-keys), 826

Adrenoceptors

alpha, functional characterization, intra-

renal arteries (rabbits), 807

alpha-i, pharmacology of XB513 (rats),1088

atpha-2cholinergic interaction, antinociception

(sheep), 536

cross-tolerance with mu opioid recep-

tors, spinal cord (rats), 551

supraspinal antinociception, N-acetyl

fl-endorphin-(1-31) and substance P(mice), 835

betablocker tertatolol (rats), 739dosing rate-dependent relationship,

propranobol plasma concentration(humans), 681

immunomodulatory effects, morphine

(rats), 1079

inotropic and beta blocking effects, chi-meric molecule (dogs), 1105

beta-i, mechanism of action, denopamine(rabbits), 1292

beta-i and beta-2, desensitization, lipo-lytic responses of adipocytes (ham-

sterS), 237

beta-2, independent relaxation in aorta,tyramine (rats), 1096

beta prejunctional, modulation of sympa-thetic neurotransmission, mesentery(rats), 657

comparison of vasodilators, lemakalim

(dogs), 1026contractile responses in vas deferens,

atrial natriuretic peptide, inhibition

of purinergic component (guineapigs), 920

pharmacokinetics and pharmacody-namics, normal children and adoles-

cents, 1232Adrenochrome, implication of oxygen radi-

cals, metabolism of cycbosporine Aand FK-506, liver microsomes (rats,humans), 1047

Aging, stereoselective pharmacokinetics andpharmacodynamics, verapamil (hu-mans), 690

Ahmed, S. S., Strobe!, H. W., Napoli, K. L.and Grevel, J.: Adrenochrome reac-tion implicates oxygen radicals inmetabolism of cyclosporine A andFK-506 in rat and human liver mi-

crosomes, 1047AIDS, gastrointestinal and hepatic first-

pass elimination, 2’,3’-dideoxyino-

sine (rats), 731

Airway, smooth muscle, functional role,phosphodiesterase isozymes (hu-mans), 1213

Akaike, A., see Tamura, Y., 1017

Albuquerque, E. X., see Alkondon, M., 1455Albuquerque, E. X., see Pereira, E. F. R.,

1474Albuquerque, M. L., see Kurth, C. D., 587

Aldershvile, J., see Boesgaard, S., 1239

Aldrich, P. E., see Wong, P. C., 1088Alhaider, A. A. and Wilcox, G. L.: Differ-

ential roles of 5-hydroxytryptamine,�and 5-hydroxytryptamine,5 receptor

subtypes in modulating spinal foci-

ceptive transmission in mice, 378

Alkondon, M. and Albuquerque, E. X.: Di-versity of nicotinic acetyicholine re-ceptors in rat hippocampal neurons.I. Pharmacological and functionalevidence for distinct structural sub-types, 1455

Amidase, -catalyzed hydrolysis, stereoselec-tivity in glutathione conjugation, 2-

1545

1546 Index Vol. 265

bromoisovalerylurea enantiomers(rats), 1406

Amilorideits derivatives and, modulation, cardiac

performance (rats), 1280

sensitivity, indomethacin- and desamino-

8-D-arginine vasopressin-induced

lithium reabsorption (humans), 1267

2-Amino-i, 4-dihydro -4-(2-4-[4-(2-methoxy-phenyl)- 1 -piperazinyl]butylsulfinyl-phenyl)-6-methyl-5-nitro-3-pyridine

carboxylic acid bmethyl ester, seeXB513

Amino acidsexcitatory

activation of nociceptive reflexes, pe-ripheral kainate receptors (rats), 927

modulation of seizure threshold, antie-pileptic drugs and chemoconvulsants(mice), 1063

substance P, modulation of kainic acid-induced activity in spinal cord (mice),159

release during ischemia and neuronal in-jury, effects of S-312-d, stroke-proneSHR rats, 463

1 -Aminobenzotriazole, N-aralkyl deriva-

tives, inhibition, pulmonary cyto-

chrome P450 (rabbit), 281�y-Aminobutyric acid, -induced depressions

of cerebellar Purkinje neurons, sen-sitization by ethanol, beta adrenergic

mechanisms in brain (rats), 4262-Aminochromomes, block ofplatelet aggre-

gation, inhibition of cAMP-depend-

ent phosphodiesterase (humans), 4571-Aminocyclopropanecarboxylic acid, chronic

treatment, adaptive changes, NMDAreceptor complex (mice), 1380

Aminoglutethimide, induction of cyto-chrome P450 2B1, liver (rats), 477

Amlodipine, action on subcutaneous resist-ance arteries (humans), 860

Amphetamine, -like discriminative stimuluseffects, stereoisomers of deprenyl

(rats), 1Analgesia

medullary hyperalgesic center, pharma-cological characteristics (rats), 286

opioid receptor regulation (mice), 314supraspinal mu systems, independent

expression, genetically differentmouse strains, 166

Anatoxin-aagonist site, nicotinic acetylcholine recep-

tors, hippocampal neurons (rats),

1474

diversity of nicotinic acetylcholine recep-tors, hippocampal neurons (rats),1455

Anday, E., see Kurth, C. D., 587Anderson, B., see Rampe, D., 1125Anderson, D. K., see Shaffer, J. E., 1105Anesthesia, trichloroethanol potentiation,

5-HT3 receptor-mediated ion current,nodose ganglion neurons (rats), 771

Anesthetics

barbiturate, depression of resting K� con-ductance, myocardium (frog), 358

inhalational, neurochemical actions, GA-BAA receptor complex (mice), 1392

isoflurane, attenuation of Ca4� mobiliza-

tion, vascular smooth muscle cells, 74

Angiotensin

neuromodulatory effects, angiotensin re-ceptors, vas deferens (rabbits), 601

peptides, prostaglandin synthesis, aortic

smooth muscle cells (pigs), 664

Angiotensin converting enzymeinhibition by N-acetylcysteine (rats),

1239inhibitor quinapril, vasoconstrictor activ-

ity, mesenteric vasculature (rats), 187

Angiotensin II

nonpeptide antagonist losartan, intrinsicproperties, glomeruli and mesangialcells (rats), 1534

prevention of salt-induced hypertension,losartan, reduced renal mass rats,

1131receptor antagonist SR 47436, pharma-

cological characterization (rats, dogs,monkeys), 826

vasoconstrictor activity in mesentericvasculature, quinapril (rats), 187

Anions

organic, kinetic analysis of hepatobiliarytransport, Eisai hyperbilirubinemicmutant rats, 1301

secretion, P2 purinergic receptors, humanbreast tumor cells, 1499

Antiandrogens, metabolic activation of flu-

tamide, cytochromes P-450 (rats, hu-mans), 366

Antiarrhythmic agents, L-691,121, novelclass III agent (guinea pigs), 720

Antibody, -forming cell response, gallium

arsenide-induced suppression, rever-

sal by vehicle supernatants (mice),144, 150

Anticholinesterase, neostigmine, mecha-

nism of bradycardia (cats), 194

Antiepileptic agents, modulation of seizure

threshold, excitatory amino acids

(mice), 1063Antihypertensive agents, methylated deny-

atives, phenyl-2-aminoethyl sulfide(rats), 1113

Antimycin A, cell death and extnacellular

acidosis, renal proximal tubules (nab-

bits), 1355

Antinociception

alpha-2 adrenocepton-mediated, cholin-

ergic interaction (sheep), 536cannabinoid-induced, blockade by nor-

binaltorphimine (mice), 633

cross-tolerance of mu opioid and alpha-2adrenergic receptors, spinal cord(rats), 551

morphine-induced, antagonism, intna-cerebnoventnicular administration of

pentobanbital (mice), 1361nicotinic, adrenergic, serotonengic and

cholinergic components (rats), 777

opioid-induced, role of neurotensin, pen-aqueducts! gray (rats), 580

profile of biphalin (mice), 1446supraspinal, N-acetyl f3-endorphin-(i-

31), substance P (mice), 835Antipsychotic agents

acute halopenidol administration, en-hanced dopaminergic transmission(rats), 1193

AD-5423 and habopenidol, pharmacologi-cal activities (rats), 745

dopamine D,/D2 and 5-HT2 receptor oc-cupation (rats), 498

NPC 16377, behavioral and neuroprotec-tive profile (rats, mice, gerbils), 876

Antisense oligodeoxynucleotides, musca�

ninic m2 receptors, short-term desen-sitization, cerebellar granule cells(rats), 433

Antonaccio, M. J., see Sargent, C. A., 609

Aortacromakalim-induced �Rb efflux, inhibi-

tion by 8-(diethylamino)-octyl-3,4,5-tnimethoxybenzoate (rats), 1399

discrimination of A2 adenosine receptors,2-phenylethoxy-9-methyladenine(guinea pigs), 248

endothelium-dependent relaxation, L-

and D-enantiomens, NG�nitno.argi�nine (rats), 112

N-0861 and its enantiomens (guinea pigs),201

pharmacological characterization, SR47436 (rats, dogs, monkeys), 826

sancoplasmic reticulum Ca� pump AT-Pase inhibitors, inhibition of relaxa-tion, nitroglycerin and atrial natri-uretic factor (rabbits), 1187

smooth muscle, pnostaglandin synthesis,

angiotensin peptides (pigs), 664

Apoptosis, morphine-like alterations, thy-mocyte subpopubations (mice), 81

Appalsamy, M., see Tseng, C.-J., 1511Appleby, S. D., see Lynch, J. J., Jr., 720Appleyand, S. M., see Horan, P. J., 1446Apnikalim, Al-selective agonist RG14202

(pigs), 699N-Analkyl-l-aminobenzotniazole, inhibition

of pulmonary cytochnome P450 (rab-bits), 281

Andaillou, R., see Chansel, D., 1534

Anecoline, diversity of nicotinic acetylcho-line receptors, hippocampal neurons

(rats), 1455

Argyrophilia, region-dependent damage tocentral nervous system, levels above

brain stem, 3,3’-iminodipropionitnile

(rats), 1492Aromatase, inhibitor aminoglutethimide,

induction of cytochrome P450 2Bl(rats), 477

Arsenic, sera of gallium arsenide-exposed

mice, inhibition of bacterial growth,increased host resistance, 795

Arterioles, cerebral, constriction, cocaine

and its metabolites (piglets), 587

Artery

antiproliferative and endothelium-dependent vasodilaton properties,

i,3-dihydno-3-p-chloro-phenyl-7-hydroxy-6-methyl-furo-(3,4c)pyri-dine hydrochloride (rats), 30

cerebral, role of nitric oxide, neurogenic

vasodilation (pig), 339coronary

Al-selective agonist RG14202 (pigs),699

comparison of vasodilators, lemakalim(dogs), 1026

epinine in tissues (human), 346regional contractile function, effects of

MCI-154 (dogs), 819relaxation, calcitonin gene-related pep-

tide (pigs), 490

intrarenal, functional characterization,alpha adrenoceptors (rabbits), 807

large vs. small, sympathetic vasomotor

control, postjunctional role of neu-nopeptide Y (rabbits), 887

pulmonary

1993

endothelial cells, mechanism of putres-cine transport (human), 60

epinine in tissues (human), 346

subcutaneous resistance, action of amlo-

dipine (humans), 860

vascular postsynaptic neuropeptide Y ne-ceptor function (rats), 172

4-(2-Arylethenyl)phenol, 2,6-disubstituted,

prodrug, orally active 5-lipoxygenase

inhibitor (monkeys), 483

2-Aryl-3-indoleacetamide, imidazopyridinederivatives and, mitochondrial diaze-

pam binding inhibitor receptors

(rats), 649Aspirin, prevention of gastrointestinal dam-

age by L-365,260 (rats), 1348Astrocytes, region-dependent damage to

central nervous system, levels abovebrain stem, 3,3’-iminodipropionitnile(rats), 1492

Atenolol, immunomodulatory effects ofmorphine, beta adrenergic receptor(rats), 1079

Atracunium, speed of action, neuromuscularjunction binding vs. buffering hy-pothesis, 1181

Atnia, N6-endonorbornan-2-yl-methyl-adenine and its enantiomers (guineapigs), 201

Atrial natniuretic factor, inhibition of relax-

ation, sarcoplasmic reticulum Ca�pump ATPase inhibitors, aorta (nab-bits), 1187

Atnial natniuretic peptide, inhibition of pur-inengic component, electrically in-duced contractile responses, vas def-erens (guinea pigs), 920

Atropine, -resistant motility, tachykinins,colon (guinea pigs), 1224

Au, J. L.-S., see Bramer, S. L., 731

Audia, J. E., see Nelson, D. L., 1272

Auenbach, S. B., see Rutten, J. J., 1319Ault, B. and Hildebnand, L. M.: Activation

of nociceptive reflexes by peripheralkainate receptors, 927

Auta, J., Romeo, E., Kozikowski, A., Ma, D.,Costa, E. and Guidotti, A.: Partici-pation of mitochrondrial diazepambinding inhibitor receptors in the an-ticonflict, antineophobic and anti-

convulsant action of 2-aryl-3-indole-acetamide and imidazopynidine de-rivatives, 649

Autoreceptors

y-aminobutynic acid, cerebral cortex andspinal cord, receptor subtypes (rats),765

central 5-HT1A and 5-HT1B, blockingproperties, penbutolol (rats), 707

-selective dopamine agonists, electro-physiological effects, AlO dopamineneurons (rats), 963

Avidin, radiolabeled deferoxamine-biotinderivatives, plasma stability andpharmacokinetics, 408

Axon, giant, structure-activity relationship,D-ning derivatives of grayanotoxin(squid), 1328

Baba, N., see Yakehiro, M., 1328Bachoo, M., see Backman, S. B., 194Backman, S. B., Bachoo, M. and Polosa, C.:

Mechanism of the bradycandia pro-duced in the cat by the anticholinest-erase neostigmine, 194

Baclofen, GABA autoneceptors, cerebralcortex and spinal cord (rats), 765

Bacteria, inhibition of growth, gallium an-

senide-exposed mice, arsenic in sena,

795

Badre, L., see Chansel, D., 1534Bailey, M., see Kanbon, E. W., 866Bakshi, V. P. and Kelley, A. E.: Feeding

induced by opioid stimulation of theventral stniatum: Role of opiate ne-ceptor subtypes, 1253

Baldwin, J. J., see Lynch, J. J., Jr., 720

Bals-Kubik, R., see Shippenbeng, T. S., 53Balsten, R. L., see Clissold, D. B., 876Bane�jee, S. P., see Lidsky, T. I., 1193Baraban, S. C., Stonnetta, R. L. and Guye-

net, P. G.: Respinatory control ofsympathetic nerve activity during

naloxone-precipitated morphine with-drawal in rats, 89

Barbituratesanesthetics, depression of nesting K� con-

ductance, myocardium (frog), 358

pentobanbital dependence, behavioral ef-fects, sedative drugs (baboons), 47

Barker, J. L., see Valeyev, A. Y., 985Barrett, R. J., May, J. M., Martin, P. L. and

Miller, J. R.: In vitro and in vivopharmacological characterization of

N6-cyclopentyl-9-methyladenine (N-0840): A selective, orally active A1adenosine receptor antagonist, 227

Banthelemy, G., see Cazaubon, C., 826

Basal ganglia, somatostatin receptors in nu-cleus accumbens, locomotor activity

(rats), 67

Basile, A. S., see Yundaydin, C., 565Baskin, E. B., see Lynch, J. J., Jr., 720Bay K 8644

airway smooth muscle function, develop-ment (guinea pigs), 524

cardiovascular effects (guinea pigs), 1125Beaudny, C., see Lugnien, C., 1142Beaune, P., see Benson, A., 366

Becker, A., see Tagani, P., 416Becker, M. W., see Donn, G. W., II, 447

Behavior

effects of sedative drugs, pentobanbitaldependence (baboons), 47

modification of effects, 4-pnopyl-9-hy-

droxynaphthoxazine, dopamine an-

tagonists (monkeys), 1039

motivational effects of opioids, neuno-

chemical substrates, mesolimbic do-

pamine system (rats), 53pharmacology of NPC 17742 (mice), 1055

Belandinelli, L., see Dennis, D. M., 543Bend, J. R., see Mathews, J. M., 281Benextnamine, vascular postsynaptic neu-

nopeptide Y receptor function (rats),172

Benjamin, C. W., Lin, A. H., Morris, J.,Wishka, D. G. and Gorman, R. R.: 2-Aminochnomones block humanplatelet aggregation by inhibitingcyclic AMP-dependent phosphodies-terase leading to reduced plateletphospholipase C activity, 457

Benloucif, S., Keegan, M. J. and Galloway,M. P.: Senotonin-facilitated dopa-mine release in vivo: Pharmacological

characterization, 373

Bennett, E. H., see Lysle, D. T., 1071Benzodiazepines

acute and repeated lonazepam exposure,

Index 1547

intravenous flumazenil (humans),

1163chronic diazepam, precipitated absti-

nence syndrome (dogs), 1152Benzomonphan, increased extracellular ace-

tylcholine levels, sigma ligands, fron-

tel cortex (rats), 851

Benzotniazine di-N-oxide, hypoxic cell cy-totoxin tirapazamine, pharmacoki-netics, bioreductive metabolism(mice), 938

Benzoxazinone, 5-methyl-4H-3,i -benzoxa-zin-4-one derivatives, inhibitors ofhuman leukocyte elastase, 516

Berg, R. A., Padbury, J. F., Donnerstein, R.L., Klewen, S. E. and Hutten, J. J.,Jr.: Dobutamine pharmacokineticsand phanmacodynamics in normalchildren and adolescents, 1232

Bergman, J., see Rosenzweig-Lipson, S.,1039

Bennhant, C., see Cazaubon, C., 826Berson, A., Wolf, C., Chachaty, C., Fisch,

C., Fau, D., Eugene, D., Loepen, J.,Gauthien, J.-C., Beaune, P., Pompon,D., Maunel, P. and Pessayne, D.: Met-abolic activation of the nitnoanomaticantiandrogen flutamide by rat and

human cytochnomes P-450, includingforms belonging to the 3A and 1Asubfamilies, 366

Bertrand, C., see Piedimonte, G., 36Beta adrenergic agonists, sensitization of

GABA-induced depressions, cenebel-lar Punkinje neurons, ethanol (rats),426

Bevan, D. R., see Glavinovic, M. I., 1181Bian, K., see Bukoski, R. D., 30Bicarbonate, modulators of electrolyte

transport, secretin and somatostatin,gallbladder epithelium (guinea pigs),273

Bijlsma, J. A., Koomans, H. A., Boer, W.H., Mees, E. J. D. and Van Rijn,H. J. M.: Indomethacin- and desa-mino-8-D-arginine vasopressin-in-

duced lithium reabsorption is notamilonide sensitive in humans, 1267

BI-L-226, prodrug of 2,6-disubstituted 4-(2-aryetheyl)phenol, 5-lipoxygenase in-

hibiton (monkeys), 483Bile, hepatobiliary excretory function,

chronic physical activity (rats), 321Billings, B., see Yoburn, B. C., 314Bilsky, E. J., see Honan, P. J., 1446Bindokas, V. P., see Foucart, S., 903Biotin, -deferoxamine derivatives, nadiola-

beling, plasma stability and pharma-cokinetics, 408

Biphalin, antinociceptive profile (mice),1446

Birkett, D. J., see Tassaneeyakul, W., 401Bleakman, D., see Foucart, S., 903

Blien, P., Lists, A. and Dc Montigny, C.:Differential properties of pre- and

postsynaptic 5-hydroxtryptaminelA

receptors in the dorsal naphe and hip-pocampus: I. Effect of spipenone, 7

Blien, P., Lists, A. and De Montigny, C.:Differential properties of pre- andpostsynaptic 5-hydroxytnyptamine1�receptors in dorsal naphe and hippo-campus: II. Effect of pertussis andcholera toxins, 16

Blood, levels of 1V6-phenylisopropyladeno-

1548 Index

sine, cardiac responses (guinea pigs),

543

Blood flow, cerebral, constriction of arteni-oles, cocaine and its metabolites (pig-

lets), 587

Blood pressure

increased intnagastnic pressure, serotonin

microinjection, nucleus raphe obscu-

rus (rats), 468

renal function and, converting enzyme in-

hibiton, neutral endopeptidase inhib-

itor (rats), 1339

Blouin, R. A., see Chaudhary, I. P., 1333BMY 14802, NPC 16377, behavioral and

neunopnotective profile (rats, mice,

gerbils), 876

Bo, J., see Bukoski, R. D., 30

Boer, W. H., see Bijlsma, J. A., 1267

Boesgaand, S., Aldenshvile, J., Poulsen, H.

E., Christensen, S., Dige-Petersen,H. and Giese, J.: N-Acetylcysteineinhibits angiotensin converting en-

zyme in vivo, 1239

B#{246}hm,M., see Schwinger, R. H. G., 346

Bonanno, G. and Raiteni, M.: y-Aminobu-tynic acid (GABA) autoneceptons in

rat cerebral cortex and spinal cord

represent pharmacologically distinct

subtypes of the GABAR receptor, 765

Bonosky, S., see Clissold, D. B., 876

Borosky, S., see Kanbon, E. W., 866Bonnoni, E., see Colzi, A., i03Bousquet, F., see Cazaubon, C., 826Bnackley, P. T. H. and Ushenwood, P. N.

R.: Are chimenic kainate/N-methyl-D-aspartate receptors expressed inXenopus oocytes from mammalian

and amphibian RNA?, 910

Brady, H. R., Zeidel, M. L., Kone, B. C.,Giebisch, G. and Gullans, S. R.: Dif-

ferential actions of cisplatin on renal

proximal tubule and inner medullany

collecting duct cells, 1421

Bradycardiamechanism, anticholinesterase neostig-

mine (cats), 194

UL-FS 49, increased atnial force, de-creased ventricular force (dogs), 801

Bradykinin

blood pressure and renal function, con-verting enzyme inhibitor, neutral en-

dopeptidase inhibitor (rats), 1339

endothelium-dependent relaxation of

aorta, L- and D-enantiomens, NG�ni�

tro-anginine (rats), 112Brain

cerebral artery, neunogenic vasodilation,role of nitric oxide (pig), 339

characterization of GABAA receptor-

channel complex (rats), 985

constriction of cerebral arterioles, cocaine

and its metabolites (piglets), 587

cortical neurons, prevention of glutamate

cytotoxicity, ifenprodil (rats), 1017

dopamine and other mechanisms, behav-ioral action of MK-801, 6-hydroxy-dopamine-lesioned rats, 1001

hepatic encephalopathy, benzodiazepine

receptor ligands (rats), 565

5-HTIA receptor antagonist tertatolol

(rats), 739

influence of estnus cycle, neurostenoid po-

tency, GABAA receptor complex

(rats), 1374

medial prefrontal cortex, intracranial co-

Caine self-administration, dopamine

turnover in nucleus accumbens

(rats), 592

medullary hyperalgesic center, pharma-

cological characteristics (rats), 286

neuronal circuits, discriminative stimulus

effects, 5-HT receptor agonists

(rats), 572

sensitization of GABA-induced depnes-

sions, ethanol, beta adrenergic mech-

anisms (rats), 426

Brain stem

mechanisms, nicotine, cardiovascular

control (rats), 1511

region-dependent damage to central nerv-

ous system, 3,3’-iminodipropionitrile

(rats), 1492

Bramer, S. L., Au, J. L.-S. and Wientjes, M.G.: Gastrointestinal and hepaticfirst-pass elimination of 2’,3’-di-

deoxyinosine in rats, 731

Brandsgaard, R. R., see Willets, J., 1055

Breast, neoplasms, P2 puninergic receptors,

1499

Breese, G. R., see Cniswell, H. E., 1001

Breliere, J.-C., see Cazaubon, C., 826Brideau, C., see Tagari, P., 416

BRL 37344, lipolytic responses of adipo-cytes, desensitization, beta- 1 and

beta-2 adrenoceptors (hamsters), 237

Brofaromine, monoamine oxidase-A inhibi-

tors, dopamine metabolism, caudatus

(rats), 103

2-Bromoisovalerylurea, enantiomers, gluta-

thione conjugation and amidase-cat-

alyzed hydrolysis, liver (rats), 1406

Bronchodilatons, functional role of phos-

phodiesterase isozymes, airway

smooth muscle (humans), 1213

Brown, M. A., see Renfro, J. L., 992Brown, R., see Burns, L. A., 795Bueno, L., see Million, M., 96

Bukoski, R. D., Bo, J., Xue, H. and Bian,K.: Antiproliferative and endothe-hum-dependent vasodilator proper-

ties of 1,3- dihydro-3-p-chloro-

phenyl-7-hydroxy-6-methyl-furo-(3,

4c) pynidine hydrochloride, 30

a-Bungarotoxin

diversity of nicotinic acetylcholine recep-

tors, hippocampal neurons (rats),

1455

ganglia-type nicotinic acetylcholine re-

ceptors, neuroblastoma clone line

(humans), 294

Burns, L. A., McCay, J. A., Brown, R. and

Munson, A. E.: Arsenic in the sera of

gallium arsenide-exposed mice inhib-

its bacterial growth and increases

host resistance, 795

Burns, L. A. and Munson, A. E.: Gallium

arsenide selectively inhibits T cell

proliferation and alters expression of

cluster designation 25 (interleukin-

2R/interleukin-2; ga chain), 178

Burns, L. A. and Munson, A. E.: Reversal

of gallium arsenide-induced suppres-

sion of the antibody-forming cell re-

sponse by vehicle supernatants. I.Pharmacokinetics after in vitro and

in vivo exposure, 144

Burns, L. A. and Munson, A. E.: Reversal

of gallium arsenide-induced suppres-

sion of the antibody-forming cell re-

sponse by vehicle supernatants. II.

Vol. 265

Nature and identification of nevers-

ing factors, 150

Buspirone, serotonergic involvement, halo-

penidol-induced catalepsy (rats), 207

2,3-Butanedione monoxime, inhibition of

delayed rectifier potassium channels,

Xenopus oocytes, 1011

t-Butyl hydroperoxide

cell death and extracellular acidosis, renal

proximal tubules (rabbits), 1355

lethal injury to hepatocytes, mitochon-

drial and glycolytic dysfunction

(rats), 392

Caffeine

drugs of abuse and cholinergic agents,

delayed matching-to-sample re-

sponding (monkeys), 120

effects of adenosine agonists, ventilation

(monkeys), 971

Cagnotto, A., see Pnisco, S., 739

Calcitonin gene-related peptide

acute effects, mechanical and electrical

responses, hemidiaphragm (rats),

1199

relaxation of coronary arteries (pigs), 490

Calcium

agonists Bay K 8644 and CGP 28392,

airway smooth muscle function dun-

ing development (guinea pigs), 524

agonist XB513, pharmacology (rats), 1088antagonist S-312-d, ischemic amino acid

release and neuronal injury, stroke-

prone SHR rats, 463attenuation of mobilization, isoflurane,

vascular smooth muscle cells, 74

differential effects of endothelin, gastriclongitudinal and circular smooth

muscle (rats), 1413

differential regulation of prostaglandin

synthesis, angiotensin peptides, aor-

tic smooth muscle cells (pigs), 664

intracellular signaling, P2 puninergic re-

ceptors, human breast tumor cells,

1499

intrinsic properties of losartan, glomeruli

and mesangial cells (rats), 1534

mechanism of action of denopamine, reg-

ulation, myocardial contractility

(rabbits), 1292

responses of circular myometnium, pro-

gesterone and mifepnistone, oxytocin

(rats), 1205

stimulated signal transduction, throm-

boxane A2, vascular smooth muscle(rats), 447

Calcium channel

action of amlodipine, subcutaneous resist-

ance arteries (humans), 860

activators BAY K 8644 and FPL 64176,

cardiovascular effects (guinea pigs),

1125

antagonist pimozide, block of cyclic

GMP-activated current, rod photo-

receptors (frog), 626

block of transient current, U-88779E,

neuroblastoma cells (mice), 529

Calcium channel blockers, inhibition of pur-

inergic component, contractile re-

sponses in vas deferens, atnial natni-

uretic peptide (guinea pigs), 920

Calcium current, reduction by neuropeptide

Y and pancreatic polypeptide, disso-

ciated neurons, superior cervical gan-

glia (rats), 903

Calcium pump, ATPAse inhibitors, inhibi-

1993 Index 1549

tion of relaxation, nitroglycerin andatnial natriuretic factor (rabbits),1187

Calder, J. A., Schachter, M. and Seven, P.S.: Ion channel involvement in theacute vascular effects of thiazide di-uretics and related compounds, 1175

Cambar, J., see Chansel, D., 1534Canalicular membrane, hepatobiliary trans-

port, kinetic analysis, organic anions(rats), 1301

Cannabinoids

-induced antinociception, blockade bynorbinaltorphimine (mice), 633

structure-activity relationships, receptorbinding, in vivo activities (rats), 218

Cantnill, E., see Murray, M., 477

Caplili, H., see Schwartz, J. B., 690

Capsaicin

activation of nociceptive reflexes, peniph-

era! kainate receptors (rats), 927

neurogenic vasodilation, neurokinin, ta-chykinin receptors, nasal mucosa(rats), 36

Carbacholdecreased muscarinic m2 mRNA, cerebel-

lan granule cells (rats), 441diversity of nicotinic acetylcholine necep-

tons, hippocampal neurons (rats),1455

-induced sodium current, ventricular

myocytes, guanine nucleotides

(guinea pigs), 641

Carbonyl cyanide p-tnifluoromethyoxy-phenylhydrazone, cell death and ex-tracellular acidosis, renal proximal

tubules (rabbits), 1355Cardiotonic agents, regional contractile

function, myocardial oxygen con-sumption, MCI-154 (dogs), 819

Cardiovascular system, acute opioid de-pendence, spinal rat, 128

Carp#{233}n#{233},C., Galitzky, J., Collon, P., Escla-pez, F., Dauzata, M. and Lafontan,M.: Desensitization of beta 1- and

beta 2-, but not beta 3, adrenoceptor-mediated lipolytic responses of adi-

pocytes after long-term norepineph-nine infusion, 237

Catalepsy, halopenidol-induced, serotonen-gic involvement (rats), 207

Catecholamines, acute opioid dependence,cardiovascular system, spinal rat, 128

Caudatus, monoamine oxidase-A inhibitors,dopamine metabolism (rats), 103

Cazaubon, C., Gougat, J., Bousquet, F., Gui-naudou, P., Gayraud, R., Lacoun, C.,Roccon, A., Galindo, G., Barthelemy,G., Gautret, B., Bennhart, C., Per-reaut, P., Breliene, J.-C., Le Fun, G.and Nisato, D.: Pharmacologicalcharacterization of SR 47436, a newnonpeptide AT1 subtype angiotensinII receptor antagonist, 826

CD25, altered expression, inhibition of Tcell proliferation, gallium arsenide(mice), 178

Cefodizime, kinetic analysis, hepatobiliarytransport, Eisai hyperbilirubinemic

mutant rats, 1301Central nervous system

central mu opioid receptor-mediatedchanges, renal function (rats), 134

functional integrity, presson and tachy-

candic effects, diphenyleneiodonium

(rats), 263intestinal mobility and nociception, Phe-

Leu-Phe-Gin-Pno-Ang-Phe-NH2amide analogs (rats), 96

region-dependent damage, levels abovebrain stem, 3,3’-iminodipnopionitnile

(rats), 1492

Cenebellan granule cellsdecreased muscaninic m2 mRNA, can-

bachol (rats), 441short-term desensitization, muscaninic m2

receptors (rats), 433

Cerebral cortex, spinal cord and, GABA au-toneceptons, receptor subtypes (rats),

765

Cesura, A. M., see Colzi, A., 103C-fibers, activation of nociceptive reflexes,

peripheral kainate receptors (rats),927

CGP 28392, airway smooth muscle function,development (guinea pigs), 524

CGP 35348, GABA autoneceptons, cerebralcortex and spinal cord (rats), 765

CGS 21680, effects of adenosine agonists,ventilation (monkeys), 971

Chachaty, C., see Benson, A., 366Chang, S. L., see Zadina, J. E., 254Chansel, D., Badre, L., Czekalski, S., Van-

denmeensch, S., Cambar, J. and An-daillou, R.: Intrinsic properties of the

nonpeptide angiotensin II antagonistlosartan in glomeruli and mesangialcells at high concentrations, 1534

Chatterjee, D., see Han, Z., 790

Chaudhary, I. P., Tuntatendtum, S., Mc-Namara, P. J., Robertson, L. W. andBlouin, R. A.: Effect of genetic obe-sity and phenobanbital treatment on

the hepatic conjugation pathways,

1333

Chemoconvulsants, modulation of seizure

threshold, excitatory amino acids

(mice), 1063Chemotolerance, thermal tolerance and,

transepithelial transport, renal epi-

thelium (flounder), 992Chemtob, S., see Varma, D. R., 1096Chen, F.-Y. and Lee, T. J.-F.: Role of nitric

oxide in neunogenic vasodilation of

porcine cerebral artery, 339Chen, J., see Simon, R. P., 24

Chen, Y. J., see Pierce, G. N., 1280Cherry, W. F., see Polhuijs, M., 1406Chiba, S., see Funukawa, Y., 801Chiu, A. T., see Wong, P. C., 1088Chloral hydrate, 5-HT3 receptor-mediated

ion current, tnichlonoethanol poten-

tiation, nodose ganglion neurons(rats), 771

Chloride, modulators of electrolyte trans-port, secnetin and somatostatin, gall-bladder epithelium (guinea pigs), 273

Chloride current, GABAA receptor-channelcomplex, characterization, brain

(rats), 985

Chlorpromazine, behavioral effects, pento-barbital dependence (baboons), 47

Cholera toxin, differential properties of 5-HT1A receptors, dorsal naphe and hip-

pocampus (rats), 16Cholinengic agents, drugs of abuse and, de-

layed matching-to-sample respond-ing (monkeys), 120

Christensen, S., see Boesgaand, 5., 1239

Churchill, P. C. and Ellis, V. R.: Phanma-cological characterization of the re-novasculan P2 puninergic receptors,334

Cicletanineacute vascular effects ofthiazide diuretics,

ion channel involvement (guinea

pigs), 1175

antipnolifenative and endothelium-de-pendent vasodilaton properties, 1,3-

dihydro-3-p-chlonophenyl-7-hy-

droxy-6-methyl-funo-(3,4c) pynidinehydrochloride (rats), 30

Cieslinski, L. B., see Torphy, T. J., 1213

Cisplatin, differential actions, renal proxi-ma! tubule, inner medullary collect-ing duct cells (rabbits), 1421

Clanemon, D. A., see Lynch, J. J., Jr., 720Clank, D., see Ackerman, J. M., 963Clank, M. A., Humphrey, S. J., Smith, M.

P. and Ludens, J. H.: Unique natri-unetic properties of the ATP-sensi-

tive K�-channel blocker glybunide onconscious rats, 933

Clarke, D. E., see Hegde, S. S., 601

8-Cl-cyclic AMP, inhibition by adenosinemetabolite, proliferation of nontrans-

formed cells, 790

Cl-HCO3 exchanger, inhibitor of, inhibi-tion of gastric acid secretion (mice),1313

Clissold, D. B., Ponteconvo, M. J., Jones, B.

E., Abreu, M. E., Kanbon, E. W., Er-ickson, R. H., Natalie, K. J., Jr., Bo-rosky, S., Hantman, T., Mansbach,R. S., Balsten, R. L., Fenkany, J. W.and Enna, S. J.: NPC 16377, a potentand selective a-ligand. II. Behavioraland neunoprotective profile, 876

Clissold, D. B., see Kanbon, E. W., 866

Clissold, D. B., see Willets, J., 1055Clonidine, alpha-2 adrenoceptor-mediated

antinociception, cholinengic interac-

tion (sheep), 536

Cocaine

drugs of abuse and cholinengic agents,delayed matching-to-sample ne-sponding (monkeys), 120

intnacnanial self-administration, medial

prefrontal cortex, dopamine turnover

in nucleus accumbens (rats), 592

metabolites and, constriction of cerebralarterioles (piglets), 587

Cohen, M. M., see Fulginiti, J., III, 1413

Colbert,J.C.,seePollock,S.H., 1113

Cole, W. C., see Pierce, G. N., 1280Collecting ducts, inner medullary and renal

proximal tubules, differential ac-tions, cisplatin (rabbits), 1421

Collon, P., see Carp#{233}n#{233},C., 237Colon

mucosa, permeability and morphology,long-chain acylcarnitines (rats), 955

neflexly evoked atnopine-resistant motil-ity, tachykinins (guinea pigs), 1224

Colussi, D. J., see Menkel, L. A., 699Colzi, A., d’Agostini, F., Cesura, A. M., Bon-

roni, E. and Da Pnada, M.: Mono.amine oxidase-A inhibitors and do-pamine metabolism in nat caudatus:Evidence that an increased cytosoliclevel of dopamine displaces reversiblemonoamine oxidase-A inhibitors invivo, 103

Compton, D. R., Rice, K. C., De Costa, B.

1550 Index

R., Razdan, R. K., Melvin, L. S.,Johnson, M. R. and Martin, B. R.:

Cannabinoid structure-activity nela-

tionships: Correlation of receptor

binding and in vivo activities, 218

Conotoxin, neuropeptide Y and pancreaticpolypeptide, reduced calcium cur-

rents, dissociated neurons from su-

penior cervical ganglia (rats), 903

Conte, B., see Panlani, M., 713Contnera, J. G., McLeskey, S. W., Holopai-

nen, I., Xu, J. and Wojcik, W. J.:Muscaninic m2 receptors in cerebellan

granule cell cultures from rat: Mech-anism of short-term desensitization,

433

Converting enzyme inhibitor, neutral endo-

peptidase inhibitor and, blood pres-

sure and renal function, hypertension

(rats), 1339

Coronary vessels, discrimination of A2 aden-

osine receptors, 2-phenylethoxy-9-

methyladenine (guinea pigs), 248

Costa, E., see Auta, J., 649Coussons, M. E., see Lysle, D. T., 1071

Cox, B. F., see Menkel, L. A., 699CP-55,940, cannabinoid structure-activity

relationships, receptor binding, in

vivo activities (rats), 218

CP-99,994, neunogenic vasodilation,neurokinin1 tachykinin receptors,

nasal mucosa (rats), 36

Cniswell, H. E., Johnson, K. B., Mueller, R.

A. and Breese, G. R.: Evidence forinvolvement of brain dopamine and

other mechanisms in the behavioral

action of the N-methyl-D-aspantic

acid antagonist MK-801 in control

and 6-hydnoxydopamine-lesioned

rats, 1001

Crofton, K. M., see Llonens, J., 1492Cnomakalim

-induced �Rb efflux, inhibition by 8-(di-ethylamino)-octyl-3,4,5-tnimethoxy-

benzoate, aorta (rats), 1399

relaxation of coronary arteries, calcitoningene-related peptide (pigs), 490

Crotoxin, induction of tolerance (mice), 41Cruciani, R. A., see Valeyev, A. Y., 985Cnuz, S. L., Salazar, L. A., Fern#{225}ndez-

Guasti, A. and Villarneal, J. E.: Quan-titative analysis of concentration-re-sponse curves for precipitated absti-nence responses in the opiate-de-pendent guinea pig ileum, 1519

Crux, S. L. and Villarreal, J. E.: Acute opioid

dependence in the cardiovascular

system of the spinal nat, 128

Cyclic AMP-dependent phosphodiestenase, block of

platelet aggregation, 2-aminochro-mones (humans), 457

modulators of electrolyte transport, secre-tin and somatostatin, gallbladder ep-

ithelium (guinea pigs), 273relaxation of coronary arteries, calcitonin

gene-related peptide (pigs), 490

Cyclic GMPactivated current

block by pimozide, rod photoneceptors

(frog), 626

N6-Cyclopentyl-9-methyladenine, pharma-cological characterization, 227

Cyclosponine Ametabolism in liven microsomes, adren-

ochrome reaction, oxygen radicals

(rats, humans), 1047

mitochondrial and glycolytic dysfunction,

lethal injury to hepatocytes (rats),

392

CYP2D1, dose- and time-dependentchanges, phencyclidine metabolite

covalent binding (rats), 1261

Cysteamine, prevention of gastrointestinal

damage by L-365,260 (rats), 1348

Cytisine, diversity of nicotinic acetylcholine

receptors, hippocampal neurons(rats), 1455

Cytochrome P450

inhibition and induction of isoenzymes,

lung (rats), 386

metabolic activation of flutamide (rats,

humans), 366

pulmonary, inhibition, N-aralkyl deniva-

tives of i-aminobenzotniazole (nab-

bits), 281

role of CYP2D1, phencyclidine metabo-lite covalent binding, dose- and time-

dependent changes (rats), 1261

Cytochnome P450 1A1, 1A2 and, specificity,

substrate and inhibitor probes (hu-

mans), 401

Cytochrome P450 2B1, induction by ami-

noglutethimide, liver (rats), 477

Cytochrome P450 2C11, growth hormone-

dependent, irreversible suppression,

monosodium glutamate (rats), 979

Cytosol, monoamine oxidase-A inhibitors,

dopamine metabolism, caudatus

(rats), 103

Cytotoxin, tinapazamine, phanmacokinetics,bioneductive metabolism (mice), 938

Czekalski, S., see Chansel, D., 1534

Dage, R. C., see Rampe, D., 1125d’Agostini, F., see Colzi, A., 103DAMGO, induction of feeding, opioid stim-

ulation, ventral stniatum (rats), 1253

Da Prada, M., see Colzi, A., 103

Dauzats, M., see Carp#{233}n#{233},C., 237Davis, T. P., see Horan, P. J., 896, 1446De Blasi, A., see Pnisco, S., 739

De Costa, B. R., see Compton, D. R., 218Defenoxamine, -biotin derivatives, radiola-

beling, plasma stability and phanma-cokinetics, 408

de Groat, W. C., see Yoshiyama, M., 844Delansonne, R., see El Alj, A., 1205de Ia Roza, G., see Okamoto, M., 41

ED-Ala2, Glu4]Deltorphin, [Cys4]- and [Ser4]-substituted derivatives, opioid delta

receptor multiplicity (mice), 896

Del Valle, J., see Wang, L., 308De Montigny, C., see Blier, P., 7, 16

Dennis, D. M., Shryock, J. and Belardinelli,L.: Correlation of (-)N6-phenyliso-propyladenosine blood levels with

cardiac responses in the anesthetizedguinea pig, 543

Denopamine, mechanism of action, regula-tion, myocandial contractility (rab-bits), 1292

Deprenyl, steneoisomers, amphetamine-likediscriminative stimulus effects (rats),

Dermorphin, central mu opioid receptor-

mediated changes, renal function(rats), 134

Desai, M. C., see Piedimonte, G., 36

Desamino-8-D-anginine vasopressin, in-

Vol. 265

duced lithium reabsorption, no ami-

bride sensitivity (humans), 1267

Detweilen, D. J., Eisenach, J. C. and Tong,C.: A cholinengic interaction in alpha�adrenoceptor-mediated antinocicep-

tion in sheep, 536

de Vry, J., see Schneiben, R., 572

Dexmedetomidinealpha-2 adrenoceptor-mediated antinoci-

ception, cholinengic interaction(sheep), 536

cross-tolerance of mu opioid and a�pha-2adnenengic receptors, spinal cord

(rats), 551

N,N-Diallyl-tynosine-aib-phenylalanine-

leucine ICI 174, 864, blockade of can-

nabinoid-induced antinociception,

norbinaltorphimine (mice), 633

Diazepam

binding inhibitor receptors, action of 2-

aryl-3-indoleacetamide and imidazo-

pynidine derivatives (rats), 649

chronic dose, precipitated abstinence syn-

drome (dogs), 1152

drugs of abuse and cholinengic agents,

delayed matching-to-sample re-

sponding (monkeys), 120

DiBona, G. F., see Kapusta, D. R., 134Dibromosulfophthalein, kinetic analysis,

hepatobiliary transport, Eisai hyper-

bilirubinemic mutant rats, 1301

2,4-Dichlorophenoxyacetic acid, thermaland chemical tolerance, transepithe-

hal transport, renal epithelium

(flounder), 992Dickenson, A. H., see Kalso, E. A., 551

2’,3’-Dideoxyinosine, gastrointestinal and

hepatic first-pass elimination (rats),

731

Dienemann, H., see Schwinger, R. H. G.,346

8-(Diethylamino)-octyl-3,4,5-tnimethoxy-

benzoate, inhibition of cromakalim-

induced �Rb efflux, aorta (rats), 1399

Dige-Petensen, H., see Boesgaard, S., 12393,4-Dihydro-1 ‘-[2-(benzofunazan-5-

yl)ethyl]-6- methanesulfonamidos-

piro[(2H)-1-benzopynan-2,4’-pipeni-dine]-4-one HCL, see L-691,121

Dihydno-$-enythnoidine, diversity of nico-

tinic acetylcholine receptors, hippo-

campal neurons (rats), 14551,3-Dihydno-3-p-chlorophenyl-7-hydroxy-6-

methyl-furo-(3,4c) pyridinehydroch-bride, antiprolifenative and endothe-hum-dependent vasodilaton proper-

ties (rats), 30

3,4-Dihydroxymethamphetamine, centraltryptophan hydroxylase activity(rats), 813

3,4-Dihydnoxyphenylacetic acid, mediation

of stress by 5-HT2 receptors, peniven-

triculan hypophysial dopaminergic

neurons (rats), 3034,4’-Diisothiocyanostilbene-2,2’-disulfonic

acid, inhibition of gastric acid secre-tion (mice), 1313

Dikshit, M., Kumani, R. and Snimal, R. C.:Pulmonary thnomboembolism-in-duced alterations in nitric oxide re-lease from rat circulating neutro-phils, 1369

meso-2,3-Dimercaptosuccinic acid, inhibi-tion of bacterial growth, gallium ar-

1993 Index 1551

senide-exposed mice, arsenic in sena,795

Dinsdale, D., see Venschoyle, R. D., 386

Diphenylmethylpiperazine, block of tnan-sient calcium channel current, U-

88779E, neuroblastoma cells (mice),529

Discriminative stimulusamphetamine-like, stereoisomers of de-

prenyl (rats), 1behavioral pharmacology of NPC 17742

(mice), 1055neunonal circuits, 5-HT receptor agonists

(rats), 572

Diuretics, thiazide, acute vascular effects,

ion channel involvement (guinea

pigs), 1175

Dix, D. I., see Jaiswal, N., 664

Dizoclipine, involvement ofbrain dopamine,

behavioral action of MK-801, 6-hy-droxydopamine-lesioned rats, 1001

DMPP, diversity of nicotinic acetylcholinereceptors, hippocampal neurons

(rats), 1455DNA, fragmentation, morphine-like altera-

tions, thymocyte subpopulations

(mice), 81Dobutamine, phanmacokinetics and phan-

macodynamics, normal children andadolescents, 1232

Domino, E. F. and Sheng, J.: Relative po-tency and efficacy of some dopamineagonists with varying selectivities forD1 and D2 receptors in MPTP-in-duced hemipankinsonian monkeys,

1387

Donati, F., see Glavinovic, M. I., 1181

Dong, X., see Tessel, R. E., 172

Donnerstein, R. L., see Berg, R. A., 1232Dopamine

agonists, relative potency and efficacy,MPTP-induced hemiparkinsonianmonkeys, 1387

antagonists, modification of behavioraleffects, 4-propyl-9-hydroxynaphthox-azine (monkeys), 1039

autonecepton-selective agonists, electro-physiological effects, AlO dopamineneurons (rats), 963

brain, behavioral action of MK-801, 6-hydroxydopamine-lesioned rats, 1001

mesolimbic system, motivational effects

of opioids, neurochemical substrates

(rats), 53metabolism in caudatus, monoamine oxi-

dase-A inhibitors (rats), 103

NPC 16377 receptor binding, neunochem-ical and neunoendocnine profile (rats,mice), 866

oxidative stress and thiol modification,

chronic halopenidol administration(rats), 1137

peniventniculan hypophysial neurons, me-diation of stress, 5-HT2 receptors(rats), 303

senotonengic involvement, haloperidol-in-

duced catalepsy (rats), 207

serotonin-facilitated release, pharmaco-logical characterization (rats), 373

transmission, acute haloperidol adminis-tration (rats), 1193

turnover in nucleus accumbens, intracra-nial cocaine self-administration, me-dia! prefrontal cortex (rats), 592

Dorn, G. W., II and Becker, M. W.: Thnom-

boxane A2 stimulated signal trans-duction in vascular smooth muscle,

447

Dorsal naphedifferential properties of 5-HT1A recep-

tons

effect of pertussis and cholera toxins

(rats), 16

effect of spiperone (rats), 7Dorsal raphe nucleus

5-HT1A receptor antagonist tertatolol(rats), 739

neunonal circuits, discriminative stimulus

effects, 5-HT receptor agonists

(rats), 572

Doughty, M. B., see Tessel, R. E., 172

Doxacunium, speed of action, neunomuscu-

Ian junction binding vs. buffering hy-

pothesis, 1181

DPEN, induction of feeding, opioid stimu-lation, ventral stniatum (rats), 1253

Dretchen, K. L., see Fleming, N. W., 1199

Duttaroy, A., see Yoburn, B. C., 314Dykstna, L. A., see Fecho, K., 1079Dykstra, L. A., see Lysle, D. T., 1071

Dynorphin A, morphine-induced antinoci-

ception, antagonism, intracenebro-ventricular administration of pento-barbital (mice), 1361

Dzwonczyk, S., see Grover, G. J., 559Dzwonczyk, S., see Sargent, C. A., 609

Ear, vasculature, postjunctional role, neu-nopeptide Y (rabbits), 887

Earl, R. A., see Wong, P. C., 1088Edema, inhibition of vascular leakage, tissue

injury, neurotensin peptides (rats),

619

Eikenburg, D. C., see Sadeghi, H. M., 657

Eisenach, J. C., see Detweilen, D. J., 536

El Alj, A., Winen, N., Lallaoui, H., Delan-

some, R., Fenne, F. and Germain, G.:

Progesterone and mifepnistone mod-ify principally the responses of cm-

cular myometnium to oxytocin in pre-

partunient rats: Comparison with re-

sponses to acetyicholine and to

calcium, 1205

El Amrani, A.-!. K., see Pham, I., 1339Elastase, inhibitors, 5-methyl-4H-3,i-ben-

zoxazin-4-one derivatives, 516Elayan, I., Gibb, J. W., Hanson, G. R., Lim,

H. K., Foltz, R. L. and Johnson, M.:Short-term effects of 2,4,5-tnihydrox-

yamphetamine, 2,4,5-tnihydnoxy-methamphetamine and 3,4-dihydrox-

ymethamphetamine on central tryp-

tophan hydroxylase activity, 813Electrical resistance, transepithelial, co-

lonic mucosa, long-chain acylcanni-

tines (rats), 955

Electrolytes, modulatons of transport, secne-

tin and somatostatin, gallbladder ep-

ithelium (guinea pigs), 273

Electnophysiology

autoneceptor-selective dopamine agonists,AlO dopamine neurons (rats), 963

GABAA receptor-channel complex, char-acterization, brain (rats), 985

inhibition of delayed rectifier potassium

channels, 2,3-butanedione monox-ime, Xenopus oocytes, 1011

Elliott, J. M., see Lynch, J. J., Jr., 720Ellis, V. R., see Churchill, P. C., 334

Encephalopathy, hepatic, benzodiazepinereceptor ligands (rats), 565

Endoh, M., see Kohi, M., 1292N6-Endonorbornan-2-yl-9-methyladenine,

enantiomers and, atnia (guinea pigs),

201

Endorphin, central mu opioid receptor-me-

diated changes, renal function (rats),

134

f3-Endorphin, opioid-induced antinocicep-

tion, role of neurotensin, peniaque-

ductal gray (rats), 580

Endothelial cells, pulmonary artery, mech-

anism of putnescine transport (hu-

man), 60Endothelin, differential effects, gastric lon-

gitudinal and circular smooth muscle

(rats), 1413Endothelium

-dependent relaxation of aorta, L- and D-

enantiomers, N�-nitro-anginine(rats), 112

-dependent vasodilator properties, 1,3-di-hydro-3-p-chlorophenyl-7-hydroxy-6-methyl-furo-(3,4c)pyridine hydro-

chloride, antiproliferative properties(rats), 30

-independent relaxation of aorta, tyra-mine (rats), 1096

Enflunane, neurochemical actions, GABAAreceptor complex (mice), 1392

Enkephalin, analog biphalin, antinocicep-

tive profile (mice), 1446

Enna, S. J., see Clissold, D. B., 876Enna, S. J., see Karbon, E. W., 866

Epidenmal growth factor, TGF-a and, inhi-bition of panietal cell function (nab-

bits), 308

Epinephnine, functional integrity and CNS

and sympathetic nervous system,presson and tachycardiac effects, di-phenyleneiodonium (rats), 263

Epinine, cardiac inotnopic actions, coronary

and pulmonary actions (human), 346Epithelium

gallbladder, modulators of electrolyte

transport, secretin and somatostatin

(guinea pigs), 273

renal, thermal and chemical tolerance,transepithelial transport (flounder),

992

Erdmann, E., see Schwinger, R. H. G., 346

Ergolines, species differences in pharmacol-

ogy, 5-HT2 receptor (rats), 1272Erickson, R. H., see Clissold, D. B., 876

Erickson, R. H., see Kanbon, E. W., 866Erythno-dt-1-(7-methylindan-4-yloxy)-3-is-

opropylaminobutan-2-ol, immuno-modulatory effects of morphine, betaadrenergic receptor (rats), 1079

Esclapez, F., see Canp#{233}n#{233},C., 237Eskuni, S., see Sill, J. C., 74

Esposito, E., see Pnisco, S., 739

Estrus cycle, influence on neurosteroid po-

tency, GABAA receptor complex(rats), 1374

Ethanol

behavioral effects, pentobanbital depend-ence (baboons), 47

prevention of gastrointestinal damage by

L-365,260 (rats), 1348sensitization of GABA-induced depres-

sions, cenebellar Purkinje neurons,brain (rats), 426

2-(4-Ethyl-1-pipenazinyl)-4-(fluorophenyl)-

5,6,7,8,9,10-hexahydno-cycloocta[bJpynidine, see AD-5423

1552 Index

Etorphine, opioid receptor regulation(mice), 314

Eugene, D., see Benson, A., 366

Evans, S. M., see Gniffiths, R. R., 1163

Ewing, R. W., see Pendley, C. E., 1348Exercise, chronic physical activity, hepa-

tobiliany excretory function (rats),321

Farina, P. R., Graham, A. G., Homon, C. A.,Lazer, E. S., Hattox, S., Riska, P.,Gundel, R. H. and Wegner, C. D.: Aprodrug of a 2,6-disubstituted 4-(2-arylethenyl)phenol is a selective andorally active 5-lipoxygenase inhibi-

ton, 483

Farrell, G. C., see Murray, M., 477Fau, D., see Benson, A., 366

Fecho, K., Dykstra, L. A. and Lysle, D. T.:Evidence for beta adrenergic receptor

involvement in the immunomodula-

tory effects of morphine, 1079

Feeding, induction by opioid stimulation,

ventral stniatum (rats), 1253

Fenflunamine, serotonergic involvement,

halopenidol-induced catalepsy (rats),

207Fentanyl, opioid receptor regulation (mice),

314

Fenkany, J. W., see Clissold, D. B., 876

Fenkany, J. W., see Karbon, E. W., 866

Ferkany, J. W., see Willets, J., 1055

Fenn#{225}ndez-Guasti, A., see Crux, S. L., 1519Ferranio, C. M., see Jaiswal, N., 664Ferre, F., see El Alj, A., 1205Feuer, P., see Kurth, C. D., 587Field electrical stimulation, contractile ne-

sponses in vas deferens, inhibition of

puninengic component, atnial natni-uretic peptide (guinea pigs), 920

Fink, G. D., see Kanagy, N. L., 1131Finn, D. A. and Gee, K. W.: The influence

of estrus cycle on neunosteroid po-

tency at the -y-aminobutynic acidA re-cepton complex, 1374

Fioramonti, J., see Million, M., 96

Fisch, C., see Benson, A., 366Fitzpatrick, L. R., see Pendley, C. E., 1348Fix, J. A., see Lecluyse, E. L., 955FK-506, metabolism in liven micnosomes,

adrenochnome reaction, oxygen radi-

cals (rats, humans), 1047

FK-1052, pharmacological characterization(rats, guinea pigs), 752

Fleming, N. W., Lewis, B. K., White, D. A.and Dnetchen, K. L.: Acute effects ofcalcitonin gene-related peptide onthe mechanical and electrical re-sponses of the rat hemidiaphragm,1199

Flezar, M. and Heisler, S.: P2-puninengicreceptors in human breast tumorcells: Coupling of intracellular cal-cium signaling to anion secretion,1499

Flumazenil, intravenous, acute and repeated

lonazepam exposure (humans), 1163Flurbiprofen

anti-inflammatory-histamine H2 antago-nist, gastric erosions (rats), 328

indomethacin and, methotnexate elimi-

nation and interaction, kidney (rats),1118

Flutamide, metabolic activation, cyto-chromes P-450 (rats, humans), 366

Foltz, R. L., see Elayan, I., 813

Ford-Hutchinson, A., see Tagani, P., 416Forebrain, acute uptake inhibition, extra-

cellular serotonin (rats), 1319

Forskolin, inhibition of panietal cell func-

tion, epidermal growth factor, TGF-

a (rabbits), 308

Foucart, S., Bleakman, D., Bindokas, V. P.and Miller, R. J.: Neunopeptide Y and

pancreatic polypeptide reduce cal-cium currents in acutely dissociated

neurons from adult rat superior cer-

vical ganglia, 903

Fournier, D. J., see Statkevich, P., 1118

Fourni#{233}-Zaluski, M.-C., see Pham, I., 1339FPL 64176, cardiovascular effects (guinea

pigs), 1125Fras, A. M., see Wang, L., 308Frazer, M. J., see Pancrazio, J. J., 358Fneier, D. 0 and Fuchs, B. A.: Morphine-

induced alterations in thymocyte

subpopulations of B6C3F1 mice, 81

Fnenette, R., see Tagani, P., 416Freund, R. K., see Lin, A. M.-Y., 426

Fromm, C., see Yurdaydin, C., 565Frontal cortex, increased extracellular ace-

tylcholine levels, sigma ligands (rats),

851

Fructose, mitochondnial and glycolytic dys-

function, lethal injury to hepatocytes

(rats), 392

Fuchs, B. A., see Freier, D. 0., 81

Fujii, K., see Uejima, Y., 516

Fujimoto, J. M., see Wang, F. S., 1361Fukuhara, A., see Imai, T., 328Fulginiti, J., III, Cohen, M. M. and More-

land, R. S.: Endothelin differentiallyaffects rat gastric longitudinal and

circular smooth muscle, 1413

$-Funaltrexamine, supraspinal mu analge-

sic systems, genetically different

mouse strains, 166

Furman, W. R., see Gniffiths, R. R., 1163

Furukawa, Y., Takayama, S., Sawaki, S.,Inoue, Y. and Chiba, S.: A brady-

candic agent, UL-FS 49, increasesatnial force and decreases ventricular

force in isolated, perfused heart prep-anations of dogs, 801

Galindo, G., see Cazaubon, C., 826Galitzky, J., see Carp#{233}n#{233},C., 237Gallamine, speed of action, neuromuscular

junction binding vs. buffering hy-

pothesis, 1181Gallbladder, epithelium, modulators of elec-

trolyte transport, secretin and soma-

tostatin (guinea pigs), 273

Gallium arsenide

-exposed mice, arsenic in sera, inhibitionof bacterial growth and increased

host resistance, 795

-induced suppression of antibody-forming

cell response, reversal by vehicle su-pennatants (mice), 144, 150

inhibition of T cell proliferation, alteredCD25 expression (mice), 178

Galloway, M. P., see Benloucif, S., 373

Ganglia

superior cervical, reduced calcium cur-

rents, neunopeptide Y and pancreatic

polypeptide (rats), 903

-type nicotinic acetylcholine receptors,nicotinic binding sites, neuno-

blastoma clone line (humans), 294

Gangliosides, GM1, treatment of focal ische-mia (rats), 24

Vol. 265

Gao, G. C. and Wei, E. T.: Xenopsin, neu-notensin, neurotensin(8-l3) and N-

acetyl-neurotensin(8-l3) inhibit van-

cular leakage in rats after tissue in-

jury, 619

Gancha, R. S., Seven, P. S. and Hughes, A.D.: The action of amlodipine on hu-man subcutaneous resistance arteriesstudied in vitro, 860

Garz#{243}n, J., see S#{225}nchez-Bl#{225}zquez,P., 835

Gasinska, I., see Polhuijs, M., 1406Gastric acid

inhibition of panietal cell function, epi-

dermal growth factor, TGF-a (nab-

bits), 308

inhibition of secretion, inhibitor of C1-

HCO3 exchanger (mice), 1313Gastrointestinal tract

hepatic first-pass elimination, 2’,3’-di-

deoxyinosine (rats), 731increased intragastnic pressure, senotonin

microinjection into nucleus naphe ob-

scunus, vagal mediation (rats), 468

prevention of damage, L-365,260 (rats),

1348

Gauthier, J.-C., see Benson, A., 366

Gautret, B., see Cazaubon, C., 826Gayraud, R., see Cazaubon, C., 826Ge, L.-J., see Zadina, J. E., 254Gee, K. W., see Finn, D. A., 1374Gehret, J. R., see Lynch, J. J., Jr., 720

Gelboin, H. V., see Tassaneeyakul, W., 401Gemba, T., Ninomiya, M., Matsunaga, K.

and Ueda, M.: Effects of a novel cal-cium antagonist, S-(+)-methyl-4,7-

dihydro-3- isobutyl-6-methyl-4-(3-

nitnophenyl)thieno [2,3-b] pyridine-

5-carboxylate (S-3l2-d), on ischemicamino acid release and neuronal in-

jury in stroke-prone, spontaneously

hypertensive rats, 463

Gene, obesity and phenobarbital treatment,

hepatic conjugation pathways (rats),

1333

Genmain, G., see El Alj, A., 1205

Giachetti, A., see Giuliani, S., 1224Gibb, J. W., see Elayan, I., 813Gicquel, S., see Million, M., 96Giebisch, G., see Brady, H. R., 1421Giese, J., see Boesgaard, S., 1239Giuliani, S., Lecci, A., Giachetti, A. and

Maggi, C. A.: Tachykinins and re-flexly evoked atnopine-nesistant mo-tility in the guinea pig colon in vivo,1224

G1104313, inotropic and beta blocking ef�fects, type III phosphodiesterase, betaadrenoceptons (dogs), 1105

Glavinovic, M. I., Law Mm, J. C., Kapural,L., Donati, F. and Bevan, D. R.:Speed of action of various muscle ne-laxants at the neuromuscular junc-tion binding vs. buffering hypothesis,1181

Glial fibnillary acidic protein, region-de-pendent damage to central nervous

system, levels above brain stem, 3,3’-iminodipropionitrile (rats), 1492

Glibenclamide, ATP-sensitive potassiumchannel blocker, no abolishment ofpneconditioning, ischemic heart(rats), 559

Glomeruli, mesangial cells and, intrinsicproperties, losartan (rats), 1534

Glutamate

Index 15531993

antagonist MK-801, sites of action, mic-tunition reflex (rats), 844

cytotoxicity, prevention by ifenprodil, po-lyamine modulatory sites of NMDAreceptors (rats), 1017

GM1 treatment of focal ischemia (rats),24

ischemic amino acid release and neunonal

injury, effects of S-312-d, stroke-

prone SHR rats, 463

Glutamic acid, increased intragastnic pres-

sure, senotonin microinjection into

nucleus raphe obscurus, vagal media-

tion (rats), 468

Glutathione, conjugation and amidase-cat-

alyzed hydrolysis, 2-bromoisovalery-lurea enantiomers, single-pass per-

fused liven (rats), 1406

Glybenclamide, Al-selective agonist

RG14202 (pigs), 699

Glybunidecromakalim-induced �Rb efflux in aorta,

inhibition by 8-(diethylamino)octyl-

3,4,5-tnimethoxybenzoate (rats),1399

natniunetic properties (rats), 933

Glycolysis, mitochondnial dysfunction and,

lethal injury to hepatocytes, t-butyl-hydroperoxide (rats), 392

Goedens, N. E. and Smith, J. E.: Intracranialcocaine self-administration into themedial prefrontal cortex increases

dopamine turnover in the nucleus ac-

cumbens, 592

Goldberg, S. R., see Yasan, S., 1

Gonzalez, W., see Pham, I., 1339

Gonman, R. R., see Benjamin, C. W., 457Goudreau, J. L., Manzananes, J., Looking-

land, K. J, and Moore, K. E.: 5HT2receptors mediate the effects of stresson the activity of peniventniculan hy-

pophysial dopaminergic neurons andthe secretion of a-melanoctye-stim-ulating hormone, 303

Gougat, J., see Cazaubon, C., 826

G proteinscanbachol-induced sodium current, yen-

tniculan myocytes (guinea pigs), 641differential properties of 5-HT1A necep-

tors, effect of pertussis and choleratoxins, dorsal naphe and hippocam-

pus (rats), 16

Graham, A. G., see Farina, P. R., 483

Graham, S. H., see Simon, R. P., 24

Grayanotoxin, D-ning derivatives, struc-

ture-activity relationship, squid giantaxon, 1328

Grevel, J., see Ahmed, 5. 5., 1047

Gniffiths, R. R., Evans, S. M., Guarino, J.

J., Roache, J. D., Furman, W. R.,

Liebson, E. and Schwam, E. M.: In-travenous flumazenil following acuteand repeated exposure to lorazepamin healthy volunteers: Antagonismand precipitated withdrawal, 1163

Gniffiths, R. R., see Lamb, R. J., 47Grizzle, M. K., see Shaffen, J. E., 1105Gross, S. S., see Szab#{243},C., 674Grover, G. J., Dzwonczyk, S., Sleph, P. G.

and Sargent, C. A.: The ATP-sensi-tive potassium channel blocker gli-

benclamide (glybunide) does not abol-ish preconditioning in isolated is-chemic nat hearts, 559

Grover, G. J., see Sargent, C. A., 609

Growth factors, epidermal growth factorand TGF-a, inhibition ofpanietal cell

function (rabbits), 308

Growth hormone, -dependent cytochromeP450 2C11, irreversible suppression,monosodium glutamate (rats), 979

Gu, Z.-Q., see Yurdaydin, C., 565Guanino, J. J., see Gniffiths, R. R., 1163

Guidotti, A., see Auta, J., 649

Guiraudou, P., see Cazaubon, C., 826Gullans, S. R., see Brady, H. R., 1421Gundel, R. H., see Farina, P. R., 483

Gunnell, M., see Owens, S. M., 1261

Guth, P. H., see Kaunitz, J. D., 948Guyenet, P. G., see Baraban, S. C., 89

Haaseth, R. C., see Horan, P. J., 896Halaka, N. N., see Lodge, N. J., 1399

Halopenidol

acute administration, enhancement, do-paminengic transmission (rats), 1193

AD-5423 and, pharmacological activities,antipsychotic efficacy and/on adverse

side effects (rats), 745

chronic administration, oxidative stress,

thiol modification (rats), 1137

increased extracellular acetylcholine 1ev-els, sigma ligands, frontal cortex

(rats), 851

-induced catalepsy, serotonengic involve-

ment (rats), 207Halothane

barbiturate anesthetics, depression of

resting K� conductance, myocandium

(frog), 358

neurochemica! actions, GABAA receptor

complex (mice), 1392Hamann, S. R., see Parvini, S., 286Hamilton, G. S., see Willets, J., 1055Han, Z., Chatterjee, D. and Wyche, J. H.:

Proliferation of nontransformed cells

is inhibited by adenosine metaboliteof but not by parental 8-Cl-cyclic

AMP, 790

Hanano, M., see Sathinakul, K., 1301

Hanson, G. R., see Elayan, I., 813

Harris, B., Wong, G. and Skolnick, P.: Neu-

rochemical actions of inhalational

anesthetics at the GABAA receptor

complex, 1392

Hart, S. D., see Wong, P. C., 1088Hartman, T., see Clissold, D. B., 876Hartman, T. L., see Willets, J., 1055

Hattox, S., see Farina, P. R., 483

Hay, D. W. P., see Torphy, T. J., 1213Hayashi, S., Hone, M. and Okada, Y.: Ionic

mechanism of minoxidil sulfate-in-

duced shortening of action potentialdurations in guinea pig ventricular

myocytes, 1527

Heartaorta and coronary vessels, discrimina-

tion of A2 adenosine receptors, 2-phenylethoxy-9-methyladenine(guinea pigs), 248

cardiovascular control, nicotine, brainstem mechanisms (rats), 1511

cardiovascular effects of Ca� channel ac-tivators, BAY K 8644 and FPL 64176(guinea pigs), 1125

electrophysiologic and antiannhythmic ac-tions, L-691,121 (guinea pigs), 720

failure

pharmacological characterization, SR47436 (rats, dogs, monkeys), 826

pharmacology of XB513 (rats), 1088

increased atnial force and decreased yen-

tnicular force, UL-FS 49 (dogs), 801

inotropic as well as coronary and pulmo-

nary actions, epinine, tissues (hu-man), 346

inotnopic beta blocker, chimenic molecule(dogs), 1105

ischemic, no abolishment of precondition-

ing, glibenclamide (rats), 559microsomal fractions, indolidan- and no-

lipram-sensitive phosphodiesterases

(dogs, humans), 1142modulation of performance, amilonide

and derivatives (rats), 1280myocardial oxygen consumption, regional

contractile function, effects of MCI-

154 (dogs), 819phanmacokinetics and phanmacody-

namics, dobutamine, normal children

and adolescents, 1232responses, N”-phenylisopnopyladenosine

blood levels (guinea pigs), 543

Hegde, S. S. and Clarke, D. E.: Character-ization of angiotensin receptors me-

diating the neuromodulatory effects

of angiotensin in the vas defenens of

the rabbit, 601Heisler, S., see Flezar, M., 1499

Hemicholinium-3, nicotinic antinocicep-

tion, adnenengic, serotonengic and

cholinergic components (rats), 777

Hemidiaphragm, mechanical and electricalresponses, acute effects, calcitoningene-related peptide (rats), 1199

Hemipankinsonian, MPTP-induced mon-

keys, relative potency and efficacy,

dopamine agonists, 1387Henniksen, S. J., see Negus, S. S., 1245

Hepatocytes, lethal injury by t-butylhydro-peroxide, mitochondrial and glyco-lytic dysfunction (rats), 392

Herman, B., see Imberti, R., 392Heroin, reinforcing effects, effect of antag-

onists, opioid mu/delta/kappa (rats),1245

Herz, A., see Shippenbeng, T. S., 53

Hightower, L. E., see Renfro, J. L., 992Hildebrand, L. M., see Ault, B., 927Hippocampus

central 5-HTIA and 5-HT,5 autoreceptor,

blocking properties, penbutolol(rats), 707

differential properties of 5-HTIA recep-

tonseffect of pertussis and cholera toxins

(rats), 16effect of spiperone (rats), 7

ischemic amino acid release and neunonal

injury, effects of S-312-d, stroke-

prone SHR rats, 463

neunonal circuits, discriminative stimulus

effects, 5-HT receptor agonists(rats), 572

neuronsagonist site, nicotinic acetylcholine re-

ceptors (rats), 1474diversity, nicotinic acetyicholine recep-

tors (rats), 1455Histamine

H2 antagonist drug complex, gastric ero-

sions (rats), 328

inhibition of panietal cell function, epi-

denmal growth factor, TGF-a (rab-bits), 308

Hjorth, S. and Sharp, T.: In vivo microdi-

1554 Index

alysis evidence for central

serotoninlA and serotoninlB autore-

ceptor blocking properties of the beta

adrenoceptor antagonist (-)penbu-

tolol, 707

Hoffman, J. I. E., see Piedimonte, G., 36

Holbrook, J. M., see Pollock, S. H., 1113

Holopainen, I., see Contrera, J. G., 433

Holt, A. G., see Yurdaydin, C., 565

Homon, C. A., see Farina, P. R., 483

Honan, P. J., Mattia, A., Bilsky, E. J., We-

ben, S., Davis, T. P., Yamamura, H.

I., Malatynska, E., Appleyard, S. M.,

Slaninova, J., Misicka, A., Lipko-

swki, A. W., Hruby, V. J. and Por-

reca, F.: Antinociceptive profile of bi-

phalin, a dimenic enkephalin analog,

1446

Horan, P. J., Wild, K. D., Misicka, A., Lip-

kowski, A., Haaseth, R. C., Hruby, V.

J., Weber, S. J., Davis, T. P., Yama-

mura, H. I. and Porreca, F.: Agonist

and antagonist profiles of [D-Ala2,

Glu4]deltorphin and its [Cys4]- and

[Ser4];-substituted derivatives: Fur-

then evidence of opioid delta receptor

multiplicity, 896

Hone, M., see Hayashi, S., 1527

Hone, S., Yano, S. and Watanabe, K.: In-

hibition of gastric acid secretion in

vivo and in vitro by an inhibitor of

C1-HC03 exchanger, 4,4’-diisothio-

cyanostilbene-2,2’-disulfonic acid,

1313

Hone, T., see Sathirakul, K., 1301

Hornby, P. J., see Knowicki, Z. K., 468

Howell, L. L.: Effects of adenosine agonists

on ventilation during hypercapnia,

hypoxia and hyperoxia in rhesus

monkeys, 971

Hruby, V. J., see Horan, P. J., 896, 1446

Hudzik, T. J. and Wenger, G. R.: Effects of

drugs of abuse and cholinergic agents

on delayed matching-to-sample re-

sponding in the squirrel monkey, 120

Hughes, A. D., see Garcha, R. S., 860

Humphrey, S. J., see Clark, M. A., 933

Husain, P. A., see Pollock, S. H., 1113

Husseini, W. K., see Piedimonte, G., 36

Hutter, J. J., Jr., see Berg, R. A., 1232

Hydrochlorothiazide, acute vascular effects

of thiazide diuretics, ion channel in-

volvement (guinea pigs), 1175

Hydrogen peroxide, cell death and extracel-

lular acidosis, renal proximal tubules

(rabbits), 1355

4-Hydroxy-a-methyl-phenyl-2-aminoethyl

sulfide, oral antihypertensive activity

(rats), 1113

Hypercapnia, hyperoxia and, effects of

adenosine agonists, ventilation

(monkeys), 971

Hyperphagia, hepatobiliary excretory func-

tion, chronic physical activity (rats),

321

Hypertension

blood pressure and renal function, con-

verting enzyme inhibitor, neutral en-

dopeptidase inhibitor (rats), 1339

effects of nicotine, brain stem mecha-

nisms, cardiovascular control (rats),

1511

pharmacological characterization, SR

47436 (rats, dogs, monkeys), 826

salt-induced, prevention by losartan, ne-

duced renal mass rats, 1131

vasoconstnictor activity in mesentenic

vasculature, quinapnil (rats), 187

Hypothermia, cannabinoid structure-activ-ity relationships, receptor binding, in

vivo activities (rats), 218

Hypoxia, effects of adenosine agonists, yen-

tilation (monkeys), 971

Ibopamine, cardiac inotropic actions, coro-

nary and pulmonary actions, epinine

(human), 346

ICI 174,864, blockade of cannabinoid-in-

duced antinociception, norbinaltor-

phimine (mice), 633

Idazoxan, nicotinic antinociception, adre-

nergic, serotonergic and cholinergic

components (rats), 777

Ifenprodil

NPC 16377, behavioral and neuroprotec-

tive profile (rats, mice, gerbils), 876

prevention of glutamate cytotoxicity, po-

lyamine modulatory sites, NMDA re-

ceptors in cortical neurons (rats),

1017

Ileum

opiate-dependent, concentration-re-

sponse curves, precipitated absence

responses (guinea pigs), 1519

pharmacological characterization of

FK1052 (rats, guinea pigs), 752

Im, H. K., Im, W. B. and Tsuzuki, K.: Se-

lective block of transient CA channel

current in mouse neuroblastoma cells

by U-88779E, 529

Im, W. B., see Im, H. K., 529

Imai, S., see Luo, D.-L., 1187

Imai, T., Fukuhara, A., Ueda, I. and Otagini,

M.: An evaluation of an anti-inflam-

matory-histamine H2 antagonist drug

complex on gastric erosions in the

rat, 328

Imberti, R., Nieminen, A.-L., Herman, B.

and Lemastens, J. J.: Mitochondrial

and glycolytic dysfunction in lethal

injury to hepatocytes by t-butylhy-

droperoxide: Protection by fructose,

cyclosporin A and tnifluoperazine,

392

Imidazopynidine, derivatives, mitochondrial

diazepam binding inhibitor receptors

(rats), 649

3,3’-Iminodipropionitnile, region-dependent

damage to central nervous system,

levels above brain stem (rats), 1492

Imipramine, chronic treatment, adaptive

changes, NMDA receptor complex

(mice), 1380

Immune status, morphine-induced altera-

tions, naltrexone (rats), 1071

Immunosuppression, gallium arsenide-in-

duced suppression, antibody-forming

cell response, reversal by vehicle su-

pernatants (mice), 144, 150

Indapamide, acute vascular effects of thia-

zide diuretics, ion channel involve-

ment (guinea pigs), 1175

Indocyanine green, kinetic analysis, hepa-

tobiliary transport, Eisai hypenbili-

rubinemic mutant rats, 1301

Indolidan, -sensitive cyclic nucleotide phos-phodiesterases, cardiac microsomal

fractions (dogs, humans), 1142

Indomethacin

endothelium-dependent relaxation of

Vol. 265

aorta, L- and D-enantiomers, NG�ni�

tro-arginine (rats), 112

flurbiprofen and, methotnexate elimina-

tion and interaction, kidney (rats),

1118

-induced lithium reabsorption, no amilor-

ide sensitivity (humans), 1267

prejunctional beta adrenoceptors, sympa-

thetic neurotnansmission, mesentery

(rats), 657

Inoue, Y., see Furukawa, Y., 801

Interleukin 2a, altered CD25 expression, in-

hibition of T cell proliferation, gal-

hum arsenide (mice), 178

Interleukins, antibody-forming cell ne-

sponse, gallium arsenide-induced

suppression, reversal by vehicle su-

pernatants (mice), 150

Intestine, motility and nociception, Phe-

Leu-Phe-Gin-Pro-Arg-Phe-NH2

amide analogs (rats), 96

Ion channel, acute vascular effects, thiazide

diuretics, related compounds (guinea

pigs), 1175

Ion current, 5-HT3 receptor-mediated,

tnichloroethanol potentiation, nodose

ganglion neurons (rats), 771

Ions, minoxidil sulfate-induce shortening,

action potential durations, ventnicu-

lan myocytes (guinea pigs), 1527

Ipsapirone, neuronal circuits, discriminative

stimulus effects, 5-HT receptor ago-

fists (rats), 572

Ischemia

amino acid release and neunonal injury,

effects of S-312-d, stroke-prone SHR

rats, 463

focal, GM1 treatment (rats), 24

Ishibashi, T., see Luo, D.-L., 1187

Isoflurane

attenuation of Ca� mobilization, vascu-

lan smooth muscle cells, 74

neurochemical actions, GABAA receptor

complex (mice), 1392

Isoproterenol

pnejunctional beta adrenoceptors, sympa-

thetic neurotnansmission, mesentery

(rats), 657

relaxation of coronary arteries, calcitonin

gene-related peptide (pigs), 490

sensitization of GABA-induced depres-sions, cerebellar Purkinje neurons,

beta adrenergic mechanisms and

ethanol (rats), 426

Iwamoto, E. T. and Marion, L.: Adrenergic,

serotonergic and cholinergic compo-

nents of nicotinic antinociception in

rats, 777

Iwasa, J., see Yakehiro, M., 1328

Jam, S., see Pierce, G. N., 1280

Jaiswal, N., Tallant, E. A., Jaiswal, R. K.,

Dix, D. I. and Fennanio, C. M.: Differ-

ential regulation of prostaglandin

synthesis by angiotensin peptides in

porcine aortic smooth muscle cells:

Subtypes of angiotensin receptors in-

volved, 664

Jaiswal, R. K., see Jaiswal, N., 664

Johansen, P. A., see Ackerman, J. M., 963

Johnson, A. L., see Wong, P. C., 1088Johnson, K. B., see Cniswell, H. E., 1001

Johnson, M., see Elayan, I., 813

Johnson, M. R., see Compton, D. R., 218

Jones, B. E., see Clissold, D. B., 876

Joyce, J. N., see Neal-Beliveau, B. 5., 207

1993

Jurkiewicz, N. K., see Lynch, J. J., Jr., 720

Kachel, D. L., see Sokol, P. P., 60

Kadowaki, M., see Nagakura, Y., 752

Kageyama, M., Yanagisawa, T. and Taina,N.: Calcitonin gene-related peptide

relaxes porcine coronary arteries viacyclic AMP-dependent mechanisms,

but not activation of ATP-sensitive

potassium channels, 490

Kainate, NMDA receptors and, expressionin Xenopus oocytes, mammalian and

amphibian RNA (rats), 910

Kainic acid, -induced activity, modulationin spinal cord, amino terminus of

substance P (mice), 159

Kaiser, C., see Karbon, E. W., 866Kalso, E. A., Sullivan, A. F., McQuay, H. J.,

Dickenson, A. H. and Roques, B. P.:Cross-tolerance between mu opioid

and alpha-2 adrenergic receptors, butnot between mu and delta opioid re-

ceptors in the spinal cord of the nat,551

Kanagy, N. L. and Fink, G. D.: Losartanprevents salt-induced hypertensionin reduced renal mass rats, 1131

Kaneko, K., see Kaunitz, J. D., 948

Kapural, L., see Glavinovic, M. I., 1181Kapusta, D. R., Obih, J. C. and DiBona, G.

F.: Central mu opioid receptor-me-

diated changes in renal function in

conscious rats, 134Karbon, E. W., Abreu, M. E., Erickson, R.

H., Kaiser, C., Natalie, K. J., Jr.,

Clissold, D. B., Bonosky, S., Bailey,

M., Martin, L. A., Pontecorvo, M. J.,Enna, S. J. and Ferkany, J. W.: NPC16377, a potent and selective a-li-gand. I. Receptor binding, neuno-chemical and neuroendocrine profile,866

Karbon, E. W., see Clissold, D. B., 876

Kashiwada, K., see Takahashi, H., 681

Kastin, A. J., see Zadina, J. E., 254Kato, K., see Luo, D.-L., 1187Kato, Y., see Uejima, Y., 516Kaunitz, J. D., Nishizaki, Y., Kaneko, K.

and Guth, P. H.: Effect of onogastnicnicotine on rat gastric mucosal gel

thickness, surface cell viability andintracellular pH, 948

Kawabata, H., see Uejima, Y., 516

Keegan, M. J., see Benloucif, 5., 373Kelley, A. E., see Bakshi, V. P., 1253

Ketansenin, increased intragastnic pressure,serotonin microinjection into nucleus

raphe obscurus, vagal mediation(rats), 468

Khlief, J. S., see Pollock, S. H., 1113Kidney

blood pressure and, converting enzymeinhibitor, neutral endopeptidase in-hibitor (rats), 1339

changes in function, central mu opioid

receptor-mediated changes (rats),134

epithelium, thermal and chemical toler-ance, transepithelial transport(flounder), 992

inner medullary collecting ducts, renalproximal tubule, differential actionsof cisplatin (rabbits), 1421

intranenal arteries, functional character-ization, alpha adrenoceptors (rab-

bits), 807

methotnexate elimination and intenac-

tion, indomethacin, flunbiprofen

(rats), 1118

nenovascular system, pharmacological

characterization, puninengic P2 recep-tons (rats), 334

Kitada,Y.,seeAbe,Y., 819Klewer, S. E., see Berg, R. A., 1232Kohi, M., Nonota, I., Takanashi, M. and

Endoh, M.: On the mechanism of ac-

tion of the beta-i partial agonist den-

opamine in regulation of myocardial

contractility: Effects on myocandial

alpha adrenoceptors and intracellular

Ca� transients, 1292

Kohsaka, M., see Nagakuna, Y., 752Kokubo, M., see Uejima, Y., 516Kone, B. C., see Brady, H. R., 1421

Koob, G. F., see Negus, S. S., 1245Koomans, H. A., see Bijlsma, J. A., 1267

Kothstein, T., see Lynch, J. J., Jr., 720

Koyama, T., see Matsubana, S., 498

Kozikowski, A., see Auta, J., 649Knowicki, Z. K. and Hornby, P. J.: Sero-

tonin microinjected into the nucleus

naphe obscurus increases intragastnic

pressure in the rat via a vagally me-

diated pathway, 468

Kumani, R., see Dikshit, M., 1369

Kurth, C. D., Monitto, C., Albuquerque, M.

L., Feuer, P., Anday, E. and Shaw,

L.: Cocaine and its metabolites con-

strict cerebral arterioles in newbornpigs, 587

Kurumiya, S., see Noda, Y., 745Kusumi, I., see Matsubana, S., 498

L-365,260, reduction of basal acid secretion,

prevention of gastrointestinal dam-

age, aspinin/ethanol/cysteamine

(rats), 1348

L-691,121, cardiac electrophysiologic and

antiarrhythmic actions (guinea pigs),

720

Laboulandine, I., see Pham, I., 1339

Lacour, C., see Cazaubon, C., 826

Lafontan, M., see Canp#{233}n#{233},C., 237Lallaoui, H., see El Alj, A., 1205Lamb, R. J. and Gniffiths, R. R.: Behavioral

effects of pentobanbital, lonazepam,

ethanol and chlorpnomazine substi-

tution in pentobarbital-dependent

baboons, 47

Lange, G. D., see Valeyev, A. Y., 985

Larson, A. A. and Sun, X.: Modulation of

kainic acid-induced activity in the

mouse spinal cord by the amino ten-

minus of substance P: Sensitivity to

opioid antagonists, 159

Lasova, L. S., see Mutafova-Yambolieva, V.

N., 920Laurenzana, E. M., see Owens, S. M., 1261Law Mm, J. C., see Glavinovic, M. I., 1181

Layer, R. T., see Nowak, G., 1380

Lazer, E. S., see Farina, P. R., 483

Le Bec, A., see Lugnien, C., 1142

Lecci, A., see Giuliani, 5., 1224

Lecluyse, E. L., Sutton, S. C. and Fix, J. A.:In vitro effects of long-chain acylcar-nitines on the permeability, transep-

ithelial electrical resistance and mor-phology of rat colonic mucosa, 955

Lee, T. J.-F., see Chen, F.-Y., 339

Le Fur, G., see Cazaubon, C., 826Lemakalim, comparison of vasodilators

(dogs), 1026

Index 1555

Lemasters, J. J., see Imberti, R., 392Lesch-Nyhan syndrome, involvement of

brain dopamine, behavioral action ofMK-801, 6-hydroxydopamine-le-sioned rats, 1001

Leukocytes, elastase inhibitors, 5-methyl-

4H-3,1-benzoxazin-4-one deniva-tives, 516

Leukotnienesgeneration and metabolism (dogs), 416

prodrug of 2,6-disubstituted 4-(2-aryleth-enyl)phenol, 5-lipoxygenase inhibitor

(monkeys), 483

Lewis, B. K., see Fleming, N. W., 1199Li, T., see Rampe, D., 1125

Lidsky, T. I. and Banenjee, S. P.: Acuteadministration of halopenidol en-

hances dopaminengic transmission,

1193

Liebson, I., see Gniffiths, R. R., 1163

Ligands, sigma, increased extracellular ace-

tylcholine levels, frontal cortex

(rats), 851

Lim, H. K., see Elayan, I., 813

Lin, A. H., see Benjamin, C. W., 457Lin, A. M.-Y., Freund, R. K. and Palmer,

M. R.: Sensitization of ‘y-aminobu-tynic acid-induced depressions of cer-

ebellar Punkinje neurons to the po-tentiative effects of ethanol by beta-adrenengic mechanisms in rat brain,426

Lipid peroxidation, differential actions of

cisplatin, inner medullary collecting

ducts, renal proximal tubule (nab-

bits), 1421

Lipkowski, A., see Honan, P. J., 896Lipkowski, A. W., see Honan, P. J., 1446Lipolysis, responses of adipocytes, desensi-

tization, beta-i and beta-2 adrenocep-tons (hamsters), 237

Lipopolysacchanides, bacterial, induction ofnitric oxide synthase, inhibition by

nifedipine (mice), 6745-Lipoxygenase

inhibitor, pnodrug, 2,6-disubstituted 4-(2-

arylethenyl)phenol) (monkeys), 483leukotniene generation and metabolism,

inhibition of MK-0591 biosynthesis

(dogs), 416Lists, A., see Blien, P., 7, 16Listeria monocytogenes, inhibition of bacte-

nial growth, gallium arsenide-exposed

mice, arsenic in sena, 795

Lithium, indomethacin-induced reabsorp-

tion, desamino-8-D-arginine vaso-

pressin (humans), 1267Liu, K., see Pierce, G. N., 1280Liu, S., see Schwartz, J. B., 690

Livenconjugation pathways, genetic obesity,

phenobarbital treatment (rats), 1333first-pass elimination, 2’,3’ -dideoxyino-

sine (rats), 731formation and metabolism of oxazepam,

nondiazepam and temazepam (mice),1429, 1437

glutathione conjugation and amidase-cat-alyzed hydrolysis, 2-bnomoisovaleryl-urea enantiomers (rats), 1406

hepatobiliary transport, kinetic analysisof organic anions, Eisai hyperbiliru-binemic mutant rats, 1301

induction of cytochrome P450 2B1, ami-noglutethimide (rats), 477

1556 Index Vol. 265

metabolic activation of flutamide, cyto-

chromes P-450 (rats, humans), 366

pharmacological characterization, SR

47436 (rats, dogs, monkeys), 826Liver microsomes, metabolism of cyclospor-

me A and FK-506, adrenochnome re-action, oxygen radicals (rats, hu-

mans), 1047Llonens, J., Crofton, K. M. and O’Callaghan,

J. P.: Administration of 3,3’-imino-dipropionitnile to the rat results in

region-dependent damage to the cen-

tral nervous system at levels above

the brain stem, 1492Locomotor activity

cannabinoid structure-activity relation-

ships, receptor binding, in vivo activ-

ities (rats), 218

somatostatin receptors in nucleus accum-

bens (rats), 67

Lodge, N. J. and Halaka, N. N.: 8-(Dieth-

ylamino)-octyl-3,4,5-trimethoxyben-

zoate inhibits cromakalim-induced

�Rb efflux from the rat aorta, 1399Loeper, J., see Benson, A., 366

Longenecken, K. L., see Sokol, P. P., 60

Longone, P., Mocchetti, I., Riva, M. A. andWojcik, W. J.: Characterization of a

decrease in muscaninic m2 mRNA in

cerebellar granule cells by carbachol,441

Lookingland, K. J., see Goudneau, J. L., 303

Lopatin, A. N. and Nichols, C. G.: 2,3-bu-

tanedione monoxime (BDM) inhibi-

tion of delayed rectifier (DRK1) po-tassium channels expressed in Xen-opus oocytes, 1011

Lonazepamacute and repeated exposure, intravenous

flumazenil (humans), 1163

behavioral effects, pentobarbital depend-

ence (baboons), 47Losartan

intrinsic properties, glomeruli and mes-angial cells (rats), 1534

prevention of salt-induced hypertension,reduced renal mass rats, 1131

Lovinger, D. M. and Zhou, Q.: Tnichloroe-thanol potentiation of 5-hydnoxytryptamine3 receptor-me-diated ion current in nodose ganglion

neurons from the adult rat, 771Lucaites, V. L., see Nelson, D. L., 1272Lucey, M. R., see Wang, L., 308Lucki, I., see Neal-Beliveau, B. 5., 207

Lucki, I., see Raynor, K., 67

Ludens, J. H., see Clank, M. A., 933Lugnien, C., Muller, B., Le Bec, A., Beaudry,

C. and Rousseau, E.: Characteriza-tion of indolidan- and rolipram-sen-

sitive cyclic nucleotide phosphodies-

tenases in canine and human cardiac

microsomal fractions, 1142

Lukas, R. J.: Expression of ganglia-type nic-otinic acetylcholine receptors andnicotinic ligand binding sites by cells

of the IMR-32 human neuroblastomaclonal line, 294

Lung

actions of epinine in tissues (human), 346

cytochnome P450, inhibition, N-aralkyl

derivatives of 1 -aminobenzotniazole(rabbits), 281

inhibition and induction, cytochnomeP450 isoenzymes (rats), 386

pulmonary artery endothelial cells, mech-

anism, putrescine transport (hu-man), 60

thromboembolism-induced alterations,

nitric oxide release, circulating neu-trophils (rats), 1369

Luo, D.-L., Nakazawa, M., Ishibashi, T.,

Kato, K. and Imai, S.: Putative, Se-

lective inhibitors of sancoplasmic re-

ticulum Ca�-pump ATPase inhibit

relaxation by nitroglycerin and atnialnatniuretic factor of the rabbit aortacontracted by phenylephnine, 1187

Luttmann, M. A., see Torphy, T. J., 1213

LY53857, nicotinic antinociception, adre-nengic, serotonergic and cholinengic

components (rats), 777Lymphocytes, thymocyte subpopulations,

morphine-like alterations (mice), 81

Lynch, C., III, see Pancnazio, J. J., 358Lynch, J. J., Jr., Wallace, A. A., Van der

Gaag, L. H., Baskin, E. B., Senik, C.

M., Gehret, J. R., Kothstein, T., Stu-pienski, R. F., Appleby, S. D., San-guinetti, M. C., Jurkiewicz, N. K.,

Zingano, G. J., Stein, R. B., Clare-

mon, D. A., Elliott, J. M., Young, M.

B. and Baldwin, J. J.: Cardiac elec-trophysiologic and antianrhythmicactions of 3,4-dihydro-l ‘-[2-(benzo-

furazan-5-yl)ethyl]-6 - methanesul-

fonamidospiro[(2H)-1-benzopyran-

2,4’-pipenidine]-4-one HC1 (L-691,

121), a novel class III agent, 720Lysle, D. T., Coussons, M. E., Watts, V. J.,

Bennett, E. H. and Dykstra, L. A.:

Morphine-induced alterations in im-

mune status: Dose dependency, corn-partment specificity and antagonismby naltrexone, 1071

Lysle, D. T., see Fecho, K., 1079

Ma, D., see Auts, J., 649Ma, P., see Wong, P. C., 1088Macheney, H. J., see Sprakties, G., 273

Macnophages, induction of nitric oxide syn-thase, bacterial lipopolysacchanide,inhibition by nifedipine (mice), 674

Maddaford, T. G., see Pierce, G. N., 1280

Maelicke, A., see Peneina, E. F. R., 1474Maggi, C. A., see Giuliani, S., 1224

Magnesium, chimenic kainate/NMDA re-

ceptors, expression in Xenopus oo-

cytes, mammalian and amphibianRNA (rats), 910

Mahan, L. C., see Valeyev, A. Y., 985

Major, T. C., Ovenhiser, R. W., Taylor, D.G., Jr. and Panek, R. L.: Effects ofquinapnil, a new angiotensin-con-

verting enzyme inhibitor, on vaso-

constrictor activity in the isolated,

perfused mesentenic vasculatune of

hypertensive rats, 187

Malatynska, E., see Horan, P. J., 1446

Mansbach, R. S., see Clissold, D. B., 876

Manzananes, J., see Goudreau, J. L., 303Manzini, S., see Panlani, M., 713

Marion, L., see Iwamoto, E. T., 777Martin, B. J., see Yiamouyiannis, C. A., 321Martin, B. R., see Compton, D. R., 218

Martin, G. E., see Pendley, C. E., 1348

Martin, L. A., see Kanbon, E. W., 866

Martin, P. L., Potts, A. A., Sykes, A. M. and

McKenna, D. G.: (±)-N6-Endonor-bornan-2-yl-9-methyladenine (N-

0816) and its enantiorners: Selective

antagonists of A1-adenosine necep-tons in guinea pig isolated atnia, 201

Martin, P. L., see Barrett, R. J., 227Martin, P. L., Ueeda, M. and Olsson, R. A.:

2-Phenylethoxy-9-rnethyladenine:An adenosine receptor antagonist

that discriminates between A2 aden-osine receptors in the aorta and thecoronary vessels from the guinea pig,

248

Martin, W. J., II, see Sokol, P. P., 60

Martin, W. R., see Parvini, S., 286Martin, W. R., see Sloan, J. W., 1152

Massaeli, H., see Pierce, G. N., 1280Mathews, J. M. and Bend, J. R.: N-Aralkyl

derivatives of 1 -arninobenzotniazoleas potent isozyme-selective mecha-

nisrn-based inhibitors of rabbit pul-

monary cytochnome P450 in vivo, 281

Matsubara, R., see Matsubara, S., 498

Matsubara, S., Matsubara, R., Kusumi, I.,

Koyama, T. and Yamashita, I.: Do-

pamine D1, D2 and senotonin2 necep-ton occupation by typical and atypical

antipsychotic drugs in vivo, 498

Matsurnoto, K., see Shinayama, T., 641

Matsunaga, K., see Gemba, T., 463Matsunaga, K., see Matsuno, K., 851

Matsuno, K., Matsunaga, K., Senda, T. and

Mita, S.: Increase in extracellularacetylcholine level by sigma ligandsin rat frontal cortex, 851

Mattia, A., see Horan, P. J., 1446Mattox, A., see Negus, S. S., 1245Maurel, P., see Benson, A., 366May, J. M., see Barrett, R. J., 227May, S. W., see Pollock, S. H., 1113

McCall, D. E., see Wong, P. C., 1088McCay, J. A., see Burns, L. A., 795

MCF-7 cells, P2 puninengic receptors (hu-mans), 1499

MCI-154, regional contractile function,rnyocardial oxygen consumption, con-onary artery stenosis (dogs), 819

McKenna, D. G., see Martin, P. L., 201McLeskey, S. W., see Contrena, J. G., 433McManus, M. E., see Tassaneeyakul, W.,

401

McNamara, P. J., see Chaudhary, I. P., 1333

McPherson, C. D., see Pierce, G. N., 1280McQuay, H. J., see Kalso, E. A., 551

MDL-72222, increased intnagastnic pres-sure, senotonin microinjection into

nucleus naphe obscurus, vagal media-

tion (rats), 468Mecamylarnine, medullary hyperalgesic

center, pharmacological charactenis-tics (rats), 286

Medial prefrontal cortex, intracranial co-caine self-administration, dopamineturnover in nucleus accumbens

(rats), 592

Mees, E. J. D., see Bijlsma, J. A., 1267

a-Melanocyte-stirnulating hormone, media-

tion of stress by 5-HT2 receptors,peniventnicular hypophysial dopami-

nengic neurons (rats), 303Melvin, L. S., see Compton, D. R., 218Mennini, T., see Pnisco, 5., 739Merkel, L. A., Rivera, L. M., Colussi, D. J.,

Pernone, M. H., Smits, G. J. and Cox,B. F.: In vitro and in vivo character-ization of an Al-selective adenosineagonist, RG14202, 699

Index 15571993

Mesangial cells, glomenuli and, intrinsicproperties, losartan (rats), 1534

Mesentery

sympathetic neurotnansmission, modula-tion by prejunctional beta adrenocep-tors (rats), 657

vasculatune, vasoconstnictor activity, qui-napril (rats), 187

Meso-2,3-dimercaptosuccinic acid, gallium

arsenide-induced suppression, anti-body-forming cell response, reversalby vehicle supernatants (mice), 144,

150

Mesolimbic system, dopamine receptors,motivational effects of opioids, neu-

rochemical substrates (rats), 53Methiothepin

differential properties of 5-HTIA necep-tons, effect of spipenone, dorsal rapheand hippocampus (rats), 7

increased intragastric pressure, serotoninmicroinjection into nucleus raphe ob-

scums, vagal mediation (rats), 468Methoctnamine, nicotinic antinociception,

adrenergic, serotonergic and cholin-engic components (rats), 777

Methotnexate, elimination and interaction,indomethacin and flurbiprofen, kid-ney (rats), 1118

S-(+)-Methyl-4,7-dihydro-3-isobutyl-6-

methyl-4-(3-nitnopheny l)thieno[2,3-

bjpyridine-5-carboxylate, see S-312-

d

N-Methyl-D-aspartsteantagonist NPC 17742, behavioral phan-

macology (mice), 10556-hydroxydopamine-lesioned rats, in-

volvement of brain dopamine, behav-ional action of MK-801, 1001

prevention of glutamate cytotoxicity,ifenpnodil, cortical neurons (rats),1017

N-Methylcarbachol, nicotinic antinocicep-tion, adrenergic, serotonergic andcholinergic components (rats), 777

Methylglyoxalbis(guanylhydrazone), mech-anism of putrescine transport, pul-

monary artery endothelial cells (hu-man), 60

5-Methyl-4H-3,1-benzoxazin-4-one, deriva-tives, inhibitors of human leukocyte

elastase, 5161-Methyl-4-phenyl-l,2,3,6.tetnahydropyni-

dine, relative potency and efficacy,dopamine agonists, hemiparkinson-ian monkeys, 1387

a-Methyl-phenyl-2-aminoethyl sulfide, oralantihypertensive activity (rats), 1113

Methylpnednisolone, morphine-like altera-tions, thymocyte subpopulations(mice), 81

Methylscopolamine, drugs of abuse and cho-linergic agents, delayed matching-to-sample responding (monkeys), 120

Michel, J.-B., see Pham, I., 1339Micnodialysis

central 5-HT1A and 5-HT1B autoreceptor,

blocking properties, penbutolol(rats), 707

GM1 treatment of focal ischemia (rats),24

increased extracellular acetylcholine lev-els, sigma ligands, frontal cortex(rats), 851

ischemic amino acid release and neunonal

injury, effects of S-312-d, stroke-

prone SHR rats, 463l,2,3,4-tetnahydro-9-aminoacnidine, ex-

tracellular concentration of acetyl-choline, stniatum (rats), 759

Microinjection, serotonin, increased intna-gastric pressure, nucleus naphe ob-

scums (rats), 468

Microiotophonesis, differential properties of5-HT1A receptors, effect of pertussisand cholera toxins, dorsal naphe andhippocampus (rats), 16

Microsomes, cardiac, indolidan- and roli-pram-sensitive cyclic nucleotidephosphodiesterases (dogs, humans),1142

Mictunition

nonadrenergic and noncholinengic con-

trol, external urethral sphincter, ni-tnic oxide (rats), 713

reflex, effects of MK-80l, sites of action(rats), 844

Midazolam, morphine-induced antinocicep-tion, antagonism, intracenebroven-

tnicular administration of pentobar-

bits! (mice), 1361Mifepnistone, progesterone and, responses

to oxytocin, circular myometnium

(rats), 1205Miller, D. W., see Tessel, R. E., 172

Miller, J. R., see Barrett, R. J., 227

Miller, R. J., see Foucant, S., 903Million, M., Fionamonti, J., Gicquel, S., Za-

jac, J. M. and Bueno, L.: Comparativeaction of Phe-Leu-Phe-Gin-Pro-Gln-

Ang-Phe-NH2 amide analogs on in-

testinal motility and nociception in

rats, 96Miners, J. 0., see Tassaneeyakul, W., 401Minoxidil sulfate, -induced shortening of

action potential durations, ionic

mechanisms, ventricular myocytes

(guinea pigs), 1527

Misicka, A., see Horan, P. J., 896, 1446Misse, G. A., see Tessel, R. E., 172

Mita, S., see Matsuno, K., 851

Mitchell, J. A., see Szab#{243},C., 674Mitochondria

diazepam binding inhibitor receptors, ac-tion of 2-aryl-3-indoleacetamide and

imidazopyridine derivatives (rats),649

differential actions of cisplatin, inner

medullary collecting ducts, renalproximal tubule (rabbits), 1421

glycolytic dysfunction and, lethal injuryto hepatocytes, t-butylhydnopenoxide

(rats), 392inhibitors, cell death and extracellular

acidosis, renal proximal tubules (rab-bits), 1355

Miuna, Y., see Noda, Y., 745

Miyamoto, Y., Portoghese, P. 5. and Take-moni, A. E.: Involvement of 62 opioidreceptors in acute dependence onmorphine in mice, 1325

MK-591, inhibition of biosynthesis, leuko-tniene generation and metabolism(dogs), 416

MK-801behavioral action, involvement of brain

dopamine, 6-hydroxydopamine-le-sioned rats, 1001

chimenic kainate/NMDA receptors,expression in Xenopus oocytes, mam-

malian and amphibian RNA (rats),910

mictunition reflex, sites of action (rats),

844Mocchetti, I., see Longone, P., 441Moclobemide, monoamine oxidase-A inhib-

itors, dopamine metabolism, cauda-tus (rats), 103

Molino, B. F., see Pendley, C. E., 1348Monitto, C., see Kurth, C. D., 587Monoamine oxidase-A, inhibitors and do-

pamine metabolism, caudatus (rats),103

Monooxygenases, inhibition and induction,cytochnome P450 isoenzymes, lung

(rats), 386

Monosodium glutamate, irreversiblesuppression, growth honmone-de-pendent cytochrome P450 2C11(rats), 979

Moore, K. E., see Goudreau, J. L., 303Moreland, R. S., see Fulginiti, J., III, 1413

Moni, J., see Nagakuna, Y., 752Morphine

activation of nociceptive reflexes, periph-era! kainate receptors (rats), 927

acute dependence, involvement, 62 opioidreceptors (mice), 1325

acute opioid dependence, cardiovascularsystem, spinal rat, 128

drugs of abuse and cholinengic agents,

delayed matching-to-sample re-sponding (monkeys), 120

immunomodulatory effects, beta adrener-gic receptor (rats), 1079

-induced alterationsimmune status, naltnexone (rats), 1071thymocyte subpopulations (mice), 81

-induced antinociception, antagonism, in-

tracerebroventriculan administrationof pentobanbital (mice), 1361

modulation of spinal nociceptive tnans-

mission, 5-HT1A and 5-HT1B receptor

subtypes (mice), 378

mu opiate receptor down-regulation, up-

regulation by naloxone, neuro-

blastoma cells (humans), 254naloxone-pnecipitated withdrawal, nespi-

natory control, sympathetic nerve ac-tivity (rats), 89

opiate-dependent ileum, concentration-response curves, precipitated absenceresponses (guinea pigs), 1519

opioid-induced antinociception, role ofneurotensin, periaqueductal gray(rats), 580

opioid receptor regulation (mice), 314

supraspinal mu analgesic systems, genet-ically different mouse strains, 166

Morris, J., see Benjamin, C. W., 457Mosqueda-Gancia, R., see Tseng, C.-J., 1511Mucosa

colonic, permeability and morphology,long-chain acylcarnitines (rats), 955

gastric mucosal gel thickness, surface cellviability and pH, effect of orogastnicnicotine (rats), 948

nasal, neurogenic vasodilation,neurokinin, tachykinin receptors(rats), 36

Mueller, R. A., see Cniswell, H. E., 1001Mulden, G. J., see Polhuijs, M., 1406Muller, B., see Lugnier, C., 1142Munson, A. E., see Burns, L. A., 144, 150,

178, 795

1558 Index

Murray, M., Cantnill, E. and Farrell, G. C.:

Induction ofcytochrome P450 2B1 in

rat liver by the aromatase inhibitor

aminoglutethirnide, 477Muscle

gastric longitudinal, endothelin effects(rats), 1413

hemidiaphragm, mechanical and electni-

cal responses, calcitonin gene-related

peptide (rats), 1199

Muscle, smooth

action ofamlodipine, subcutaneous resist-

ance arteries (humans), 860airway

functional role, phosphodiesterase iso-zymes (humans), 1213

function during development, Bay K

8644 and CGP 28392 (guinea pigs),524

antiprolifenative and endothelium-

dependent vasodilator properties,

1 ,3-dihydno-3-p-chlonophenyl- 7-hydroxy-6-methyl-funo-(3,4c)pyni-

dine hydrochloride (rats), 30

aortic, prostaglandin synthesis, angioten-

sin peptides (pigs), 664circular, endothelin effects (rats), 1413

cromakalim-induced �Rb efflux in aorta,

inhibition by 8-(diethylamino)-octyl-3,4,5-tnimethoxybenzoate (rats),

1399

mesentenic vasculatune, vasoconstnictoractivity, quinapril (rats), 187

relaxation of coronary arteries, calcitonin

gene-related peptide (pigs), 490

vascular

attenuation of Ca� mobilization,isoflurane, 74

stimulated signal transduction, throm-boxane A2 (rats), 447

vas deferens, contractile responses, atnial

natniuretic peptide (guinea pigs), 920

Muscle relaxants, speed of action, neuro-

muscular junction binding, buffering

hypothesis, 1181Mutafova-Yambolieva, V. N., Venkova, K.

M. and Lasova, L. S.: Atnial natni-uretic peptide inhibits the puninergicand not the adrenengic component of

electrically induced contractile re-

sponses in guinea pig vas deferens,

920Myocardium

contractility, mechanism of action, deno-

pamine (rabbits), 1292

depression of resting K� conductance,

barbiturate anesthetics (frog), 358

infarction, electrophysiologic and antiar-

rhythmic actions, L-691,121 (guinea

pigs), 720

ischemia, cardioprotection with zofeno-

pnil, ATP-sensitive potassium chan-

nel (rats), 609

Myocytes

ventricular

action potential durations, minoxidil

sulfate-induced shortening (guineapigs), 1527

canbachol-induced sodium current,

guanine nucleotides (guinea pigs),641

Myometnium, circular, progesterone and mi-

fepnistone, responses to oxytocin

(rats), 1205

N-0840, pharmacological characterization,

227N-0861, its enantiomers and, atnia (guinea

pigs), 201Na7Ca� exchange, amilonide and its deny-

atives, modulation, cardiac perform-ance (rats), 1280

Nadel, J. A., see Piedimonte, G., 36

Nadolol, immunomodulatory effects of mor-phine, beta adrenengic receptor (rats),

1079

Nagakura, Y., Kadowaki, M., Tokoro, K.,Tomoi, M., Moni, J. and Kohsaka,M.: Pharmacological characteniza-

tion of FK1052, a dihydropynidoin-dole derivative, as a new serotonin 3and 4 dual receptor antagonist, 752

Nakajima, S., see Yakehiro, M., 1328

Nakamura, K. T., see Pichoff, B. E., 524

Nakazawa, M., see Luo, D.-L., 1187

Naloxonazine, supraspinal mu analgesicsystems, genetically different mousestrains, 166

Naloxoneacute opioid dependence, cardiovascular

system, spinal rat, 128blockade of cannabinoid-induced antino-

ciception, norbinaltorphimine

(mice), 633

mu opiate receptor up-regulation, neuro-

blastoma cells (humans), 254nicotinic antinociception, adrenergic, se-

rotonergic and cholinergic compo-

nents (rats), 777opiate-dependent ileum, concentration-

response curves, precipitated absence

responses (guinea pigs), 1519opioid receptor regulation (mice), 314-precipitated morphine withdrawal, res-

piratory control, sympathetic nerve

activity (rats), 89Naltrexone

medullary hyperalgesic center, pharma-cological characteristics (rats), 286

morphine-induced alterations of immune

status (rats), 1071thymocyte subpopulations (mice), 81

Naltniben, naltnindole 5’-isothiocyanateand, #{244}2opioid receptors, acute de-pendence on morphine (mice), 1325

Napoli, K. L., see Ahmed, S. S., 1047Nanimatsu, A., see Abe, Y., 819Natalie, K. J., Jr., see Clissold, D. B., 876Natalie, K. J., Jr., see Kanbon, E. W., 866Nathanson, J. A.: Identification of octopa-

minergic agonists with selectivity for

octopamine receptor subtypes, 509Natniuresis, properties of glybunide (rats),

933

Neal-Beliveau, B. S., Joyce, J. N. and Lucki,I.: Serotonergic involvement in halo-

penidol-induced catalepsy, 207

Negus, S. S., Henniksen, S. J., Mattox, A.,Pasternak, G. W., Portoghese, P. S.,

Takemoni, A. E., Weingen, M. B. and

Koob, G. F.: Effect of antagonistsselective for mu, delta and kappaopioid receptors on the reinforcingeffects of heroin in rats, 1245

Nejat, R. J., see Pick, C. G., 166Nelson, D. L., Lucaites, V. L., Audia, J. E.,

Nissen, J. S. and Wainscott, D. B.:Species differences in the pharmacol-ogy of the 5-hydroxytryptamine2 re-ceptor: Structurally specific differ-

Vol. 265

entiation by engolines and trypta-

mines, 1272Nelson, R., see Sill, J. C., 74

Neonates, constriction of cerebral arteni-oles, cocaine and its metabolites (pig-lets), 587

Neostigminealpha-2 adrenoceptor-mediated antinoci-

ception, cholinergic interaction

(sheep), 536

drugs of abuse and cholinergic agents,delayed matching-to-sample ne-

sponding (monkeys), 120mechanism of bradycandia (cats), 194

Nephrotoxicity, differential actions of cis-platin, inner medullary collectingducts, renal proximal tubule (nab-bits), 1421

Neuroblastomablock of transient calcium channel cur-

rent, U-88779E (mice), 529clone line, ganglia-type nicotinic acetyl-

choline receptors (humans), 294mu opiate receptor, up-regulation by mor-

phine, down-regulation by naloxone

(humans), 254Neuromuscular junction

binding or buffering hypothesis, speed ofaction, muscle relaxants, 1181

induction of tolerance to crotoxin (mice),41

NeuronsAlO dopamine, electrophysiologica! ef-

fects, autonecepton-selective agonists(rats), 963

cerebellar Punkinje, sensitization of

GABA-induced depressions, beta ad-

renergic mechanisms in brain (rats),

426

cortical, prevention of glutamate cytotox-

icity, ifenprodil (rats), 1017dissociated from superior cervical ganglia,

reduced calcium currents, neunopep-

tide Y and pancreatic polypeptide(rats), 903

dorsal raphe and hippocampus

5-HT1A receptors, effect of spipenone

(rats), 7

5-HT1A receptors, effect of pertussis

and cholera toxins (rats), 16

hippocampal

agonist site, nicotinic acetylcholine ne-ceptons (rats), 1474

diversity, nicotinic acetylcholine necep-

tons (rats), 1455injury and ischemic amino acid release,

effects of S-3l2-d, stroke-prone SHRrats, 463

nodose ganglion, tnichlonoethanol poten-tiation, 5-HT3 receptor-mediated ioncurrent (rats), 771

peniventnicular hypophysial dopami-

nengic, stress, 5-HT2 receptors (rats),

303Neuropeptide Y

pancreatic polypeptide and, reduction of

calcium currents, dissociated neuronsfrom superior cervical ganglia (rats),

903postjunctional role, sympathetic vasomo-

ton control, large vs. small arteries(rabbits), 887

vascular postsynaptic receptor function,benextramine protection studies(rats), 172

1993

Neurostenoids, potency, influence of estruscycle, GABAA receptor complex(rats), 1374

Neurotensinneunotensin(8-13) and, inhibition of vas-

cular leakage, tissue injury (rats), 619nucleus raphe magnus, opioid-induced an-

tinociception, peniaqueductal gray

(rats), 580

Neurotoxicity, region-dependent damage to

central nervous system, levels abovebrain stem, 3,3’-iminodipnopionitnile(rats), 1492

Neurotoxin, induction of tolerance to cro-toxin (mice), 41

Neunotnansmission

neunomodulatory effects of angiotensin,

angiotensin receptors, vas deferens(rabbits), 601

sympathetic, mesentery, prejunctiona!beta adrenoceptons (rats), 657

Neurotransmittens, senotonin-facilitateddopamine release, pharmacologicalcharacterization (rats), 373

Neutral endopeptidase inhibitor, converting

enzyme inhibitor and, blood pressureand renal function, hypertension(rats), 1339

Neutrophils, circulating, pulmonary thnom-

boembolism-induced alterations, ni-

tnic oxide release (rats), 1369

Nichols, C. G., see Lopatin, A. N., 1011

Nicol, G. D.: The calcium channel antago-nist, pimozide, blocks the cyclicGMP-activated current in rod pho-toneceptons, 626

Nicotine

antinociception, adrenergic, senotonergic

and cholinengic components (rats),777

brain stem mechanisms, cardiovascularcontrol (rats), 1511

diversity of nicotinic acetylcholine recep-tons, hippocampal neurons (rats),

1455drugs of abuse and cholinengic agents,

delayed matching-to-sample re-sponding (monkeys), 120

ganglia-type nicotinic acetylcholine re-ceptors, neuroblastoma clone line

(humans), 294onogastnic, gastric mucosal gel thickness,

surface cell viability and pH (rats),948

pharmacological characteristics, medul-lary hyperalgesic center (rats), 286

Nieminen, A.-L., see Imberti, R., 392Nifedipine

effects of lemakalim, comparison of vaso-dilators (dogs), 1026

inhibition of induction of nitric oxide syn-thase, bacterial lipopolysacchanide(mice), 674

Nilutamide, metabolic activation of flutam-ide, cytochnomes P-450 (rats, hu-mans), 366

Ninomiya, M., see Gemba, T., 463Nisato, D., see Cazaubon, C., 826Nishizaki, Y., see Kaunitz, J. D., 948

Nissen, J. S., see Nelson, D. L., 1272Nitrate, inhibition of angiotensin convert-

ing enzyme, N-acetylcysteine (rats),1239

Nitric oxide

inhibitory control of external urethral

sphincter (rats), 713

pharmacological characterization, reno-vascular P2 puninengic receptors(rats), 334

pulmonary thromboembolism-induced al-

tenations, release from circulating

neutnophils (rats), 1369

role in neurogenic vasodilation, cerebral

artery (pig), 339Nitric oxide synthase

functional integrity of CNS and sympa-

thetic nervous system, presson and

tachycardiac effects, diphenyleneio-

donium (rats), 263

induction by bacterial lipopolysacchanide,

inhibition by nifedipine (mice), 674NG�Nitno�angmnmne, L- and D-enantiomers,

endothelium-dependent relaxation,

aorta (rats), 112

Nitnoanomatic compounds, metabolic acti-

vation of flutamide, cytochromes P-

450 (rats, humans), 366

Nitroglycerin

effects of lemakalim, comparison of vaso-

dilators (dogs), 1026

inhibition of relaxation, sancoplasmic re-ticulum Ca�� pump ATPase inhibi-

tons, aorta (rabbits), 1187

Nociception

activation of nociceptive reflexes, peniph-

era! kainate receptors (rats), 927

intestinal mobility and, Phe-Leu-Phe-Gin-Pro-Arg-Phe-NH2 amide ana-

logs (rats), 96modulation of kainic acid-induced actiy-

ity, amino terminus of substance P,spinal cord (mice), 159

spinal transmission, modulation, 5-HTIA

and 5-HT,5 receptor subtypes (mice),

378

Noda, Y., Kurumiya, S., Miura, Y. and Oka,

M.: Comparative study of 2-(4-ethyl-1-pipenazinyl)-4-(fluonophenyl) -5,6,

7,8,9,10-hexahydro-cycloocta[b]pyni-dine (AD-5423) and halopenidol fortheir pharmacological activities re-lated to antipsychotic efficacy and/

or adverse side-effects, 745

Non-steroidal anti-inflammatory drugs,anti-inflammatory-histamine H2 an-

tagonist, gastric erosions (rats), 328Norbinaltorphimine, blockade of cannabi-

noid-induced antinociception (mice),

633

Nondberg, A., see Xiao, W.-B., 759

Nondiazepam, temazepam and, formation

and metabolism of oxazepam, liven

(mice), 1429, 1437

Norepinephnine

constriction of cerebral arterioles, cocaine

and its metabolites (piglets), 587functional characterization, alpha adre-

noceptors, intrarenal arteries (rab-bits), 807

functional integrity and CNS and sym-

pathetic nervous system, pnessor and

tachycandic effects, diphenyleneio-donium (rats), 263

lipolytic responses of adipocytes, desen-sitization, beta-i and beta-2 adre-noceptors (hamsters), 237

prejunctional beta adrenoceptons, sympa-thetic neunotransmission, mesentery(rats), 657

Index 1559

sensitization of GABA-induced depres-

sions, cenebellan Punkinje neurons,beta adnenergic mechanisms andethanol (rats), 426

Nonmandin, D., see Sargent, C. A., 609Nonota, I., see Kohi, M., 1292Nowak, G., see Yurdaydin, C., 565Nowak, G., Trullas, R., Layer, R. T., Skol-

nick, P. and Paul, I. A.: Adaptive

changes in the N-methyl-D-aspartate

receptor complex after chronic treat-ment with imipramine and 1-amino-cyclopropanecanboxylic acid, 1380

NPC 16377

behavioral and neuroprotective profile

(mice, rats, gerbils), 876

receptor binding, neunochemical and neu-

noendocnine profile (rats, mice), 866NPC 17742, behavioral pharmacology

(mice), 1055Nucleotide phosphodiestenases, cyclic, in-

dolidan- and nolipram-sensitive, car-

diac microsomal fractions (dogs, hu-mans), 1142

Nucleus accumbensdopammne turnover, intracranial cocaine

self-administration, medial prefron-

tal cortex (rats), 592motivational effects of opioids, neuno-

chemical substrates, mesolimbic do-pamine system (rats), 53

somatostatin receptors, locomotor activ-ity (rats), 67

Nucleus raphe magnus, opioid-induced an-

tinociception, role of neurotensin,peniaqueductal gray (rats), 580

Nucleus raphe obscurus, serotonin microin-

jection, increased intnagastric pres-

sure, vagal mediation (rats), 468

Obesity, phenobarbital treatment and, he-

patic conjugation pathways (rats),1333

Obih, J. C., see Kapusts, D. R., 134O’Callaghan, J. P., see Llorens, J., 1492

Ochratoxin A, cell death and extracellulanacidosis, renal proximal tubules (nab-

bits), 1355

Octopaminengic agonists, selectivity for oc-topamine receptor subtypes (fireflies,hornworms), 509

Ogats, H., see Takahashi, H., 681Ogonowski, A. A., see Pollock, S. H., 11138-OH-DPAT

5-HT1A receptor antagonist tertatolol,brain (rats), 739

increased intragastnic pressure, senotonin

microinjection into nucleus naphe ob-

scurus, vagal mediation (rats), 468

neuronal circuits, discriminative stimuluseffects, 5-HT receptor agonists

(rats), 572

senotonengic involvement, halopenidol-in-

duced catalepsy (rats), 207Ohina, M., see Takahashi, H., 681

Oka, M., see Nods, Y., 745

Okada, Y., see Hayashi, 5., 1527

Okamoto, M., Viskatis, L. J., de la Roza, G.and Vidal, J. C.: Induction of toler-ance to crotoxin in mice, 41

Olsson, R. A., see Martin, P. L., 248Oocytes

Xenopus

chimenic kainate/NMDA receptors,mammalian and amphibian RNA(rats), 910

1560 Index Vol. 265

inhibition of delayed rectifier potas-

sium channels, 2,3-butanedione mon-oxime, 1011

Opiates

acute opioid dependence, cardiovascularsystem, spinal rat, 128

-dependent ileum, concentration-re-

sponse curves, precipitated absence

responses (guinea pigs), 1519

Opioidsacute dependence, cardiovascular system,

spinal rat, 128

antagonists, modulation of kainic acid-induced activity, spinal cord (mice),159

behavioral effects of sedative drugs, pen-

tobanbital dependence (baboons), 47

delta receptor multiplicity, substituted

deltorphins (mice), 896-induced antinociception, role of neuro-

tensin, peniaqueductal gray (rats),580

intestinal mobility and nociception, Phe-Leu-Phe-Gin-Pro-Arg-Phe-NH2amide analogs (rats), 96

motivational effects, neunochemical sub-

strates, mesolimbic dopamine system

(rats), 53

naloxone-pnecipitated morphine with-

drawal, respiratory control, sympa-thetic nerve activity (rats), 89

receptor regulation (mice), 314

reinforcing effects of heroin, effect of an-

tagonists, opioid mu/delta/kappa

(rats), 1245

stimulation, induction of feeding, ventral

stniatum (rats), 1253

Oshida, J.-I., see Uejima, Y., 516

Otagini, M., see Imai, T., 328

Ouabain, hepatobiliary excretory function,chronic physical activity (rats), 321

Overhisen, R. W., see Major, T. C., 187Owen, M. P.: Functional characterization of

alpha adrenoceptons on rabbit intra-renal arteries in vitro, 807

Owen, M. P.: Similarities and differences inthe postjunctional role for neunopep-tide Y in sympathetic vasomoton con-

tro! of large vs. small arteries of nab-bit renal and ear vasculatune, 887

Owens, S. M., Gunnell, M., Laurenzana, E.M. and Valentine, J. L.: Dose- andtime-dependent changes in phency-clidine metabolite covalent bindingin rats and the possible role ofCYP2D1, 1261

Oxazepam, formation and metabolism, non-diazepam and temazepam, liven(mice), 1429, 1437

Oxidants, -induced cell death, extracellulanacidosis, renal proximal tubules (rab-bits), 1355

Oxygenconsumption, effects of MCI-154, coro-

nary artery stenosis (dogs), 819

oxidative stress and thiol modification,chronic administration, halopenidol(rats), 1137

Oxygen free radicalsadrenochnome reaction, metabolism of cy-

closponine A and FK-506, liver mi-crosomes (rats, humans), 1047

differential actions of cisplatin, innermedullary collecting ducts, renalproximal tubule (rabbits), 1421

Oxytocin, progesterone and mifepnistone,responses of circular myometnium

(rats), 1205

Padbury, J. F., see Berg, R. A., 1232Palmer, M. R., see Lin, A. M.-Y., 426Pamponi, N. A., see Shapiro, B. H., 979

Pancnazio, J. J., Fnazen, M. J. and Lynch,

C., III: Barbiturate anesthetics de-press the nesting K� conductance of

myocardium, 358

Pancreas, polypeptide and neuropeptide Y,

reduction of calcium currents, disso-

ciated neurons from superior cervicalganglia (rats), 903

Pancuronium, speed of action, neuromus-

cular junction binding vs. buffering

hypothesis, 1181

Panek, R. L., see Major, T. C., 187Pang, C. C. Y., see Wang, Y.-X., 112, 263

Pang, K. S., see Polhuijs, M., 1406

Pang, K. S., see St-Pierre, M. V., 1429, 1437

Pappano, A. J., see Shinayama, T., 641Parasympathetic nervous system, mecha-

nism of bnadycandia, anticholinest-erase neostigmine (cats), 194

Panietal cells, inhibition of function, epider-

mal growth factor, TGF-a (rabbits),308

Parker, S. L., see Renfro, J. L., 992Parkinson’s disease, involvement of brain

dopamine, behavioral action of MK-801, 6-hydroxydopamine-lesionedrats, 1001

Parlani, M., Conte, B. and Manzini, S.:

Nonadrenengic, noncholinengic in-hibitory control of the rat external

urethral sphincter: Involvement ofnitric oxide, 713

Parvini, S., Hamann, S. R. and Martin, W.R.: Pharmacologic characteristics ofa medullary hyperalgesic center, 286

Pastennak, G. W., see Negus, S. S., 1245Pastennak, G. W., see Pick, C. G., 166Patch clamp

barbiturate anesthetics, depression of

nesting K� conductance, myocardium

(frog), 358

GABAA receptor-channel complex, char-actenization, brain (rats), 985

Paul, I. A., see Nowak, G., 1380

Penbutolol, central 5-HT1A and 5-HT1B au-

tonecepton, blocking properties, pen-butolol (rats), 707

Pendley, C. E., Fitzpatrick, L. R., Ewing, R.

W., Molino, B. F. and Martin, G. E.:The gastnin/cholecystokinin-B re-ceptor antagonist L-365,260 reducesbasal acid secretion and prevents gas-trointestinal damage induced by as-pirin, ethanol and cysteamine in the

nat, 1348

Pentobarbital

barbiturate anesthetics, depression ofnesting K� conductance, myocardium(frog), 358

dependence, behavioral effects, sedativedrugs (baboons), 47

drugs of abuse and cholinengic agents,delayed matching-to-sample re-sponding (monkeys), 120

intracenebroventnicular administration,

antagonism, morphine-induced an-tinociception (mice), 1361

Peptides, somatostatin receptors in nucleus

accumbens, locomotor activity (rats),67

Pereina, E. F. R., Reinhardt-Maelicke, S.,

Schnattenholz, A., Maelicke, A. and

Albuquerque, E. X.: Identification

and functional characterization of anew agonist site on nicotinic acetyl-choline receptors of cultured hippo-

campal neurons, 1474Peniaqueductal gray, opioid-induced antin-

ociception, role of neurotensin, nu-

cleus raphe magnus (rats), 580Perreaut, P., see Cazaubon, C., 826

Pennone, M. H., see Merkel, L. A., 699Pertussis toxin

differential properties of 5-HT1A recep-tons, dorsal raphe and hippocampus(rats), 16

short-term desensitization, muscarinic m2

receptors, cenebellar granule cells(rats), 433

Pessayre, D., see Benson, A., 366

Petersen, K.-U., see Spnakties, G., 273pH, gastric mucosal gel thickness, surface

cell viability, effect of onogastnic nic-otine (rats), 948

Phaclofen, GABA autoreceptons, cerebral

cortex and spinal cord (rats), 765Pham, I., Gonzalez, W., El Amrani, A.-I. K.,

Fourni#{233}-Zaluski, M.-C., Philippe, M.,

Laboulandine, I., Rouques, B. P. andMichel, J.-B.: Effects of convertingenzyme inhibitor and neutral endo-peptidase inhibitor on blood pressureand renal function in experimentalhypertension, 1339

Phe-Leu-Phe-Gin-Pno-Gln-Arg-Phe-NH2amide, analogs, intestinal motility,nociception (rats), 96

Phenacetin, specificity of substrate and in-hibiton probes, cytochromes P450

1A1 and 1A2 (humans), 401Phencyclidine

drugs of abuse and cholinergic agents,

delayed matching-to-sample re-sponding (monkeys), 120

metabolite covalent binding, dose- andtime-dependent changes, role of

CYP2D1 (rats), 1261Phenobarbital

barbiturate anesthetics, depression of

nesting K� conductance, myocardium

(frog), 358genetic obesity and, hepatic conjugation

pathways (rats), 1333

Phenyl-2-aminoethyl sulfide, methylatedderivatives, oral antihypertensive ac-

tivity (rats), 1113

Phenylephrinesensitization of GABA-induced depres-

sions, cenebellar Purkinje neurons,

beta adrenergic mechanisms (rats),426

vasoconstnictor activity in mesentenic

vasculature, quinapnil (rats), 1872-Phenylethoxy-9-methyladenine, A2 aden-

osine receptor discrimination, aortaand coronary vessels (guinea pigs),248

Phenylethylamines, endothelium- and beta-2 adrenoceptor-independent relaxa-tion, aorta (rats), 1096

Phenyl(imino)imidazolidine, octopami-

nergic agonists, selectivity, octopa-

1993 Index 1561

mine receptor subtypes (fireflies,

honnwonms), 509IV�-Phenylisopropyladenosine, blood levels,

correlation with cardiac responses

(guinea pigs), 543Philippe, M., see Pham, I., 1339

Phosphodiesterase

cAMP-dependent, block ofplatelet aggre-gation, 2-aminochnomones (hu-

mans), 457

effects of adenosine agonists, ventilation

(monkeys), 971indolidan- and rolipram-sensitive, cardiac

microsomal fractions (dogs, hu-

mans), 1142isozymes, functional role, airway smooth

muscle (humans), 1213

type III, chimenic molecule, inotropic andbeta blocking effects (dogs), 1105

Phospholipase A2, induction of tolerance to

crotoxin (mice), 41Phospholipase C

block of platelet aggregation by 2-ami-nochnomones, inhibition of cAMP-

dependent phosphodiesterase (hu-mans), 457

stimulated signal transduction, throm-boxane A2, vascular smooth muscle(rats), 447

Photoaffinity labeling, leukotniene genera-tion and metabolism, inhibition of

MK-0591 biosynthesis (dogs), 416

Photoneceptors, nod, block of cyclic GMP-

activated current, pimozide (frog),626

Physostigmine

agonist site, nicotinic acetylcholine necep-

tons, hippocampal neurons (rats),1474

drugs of abuse and cholinengic agents,

delayed matching-to-sample ne-sponding (monkeys), 120

Pichoff, B. E., Uyehara, C. F. T. and Nak-

amuna, K. T.: Effect of calcium ago-nists, BAY K 8644 and CGP 28392,on guinea pig airway smooth muscle

function during development, 524Pick, C. G., Nejat, R. J. and Pasternak, G.

W.: Independent expression of twopharmacologically distinct supraspi-nal mu analgesic systems in geneti-cally different mouse strains, 166

Piedimonte, G., Hoffman, J. I. E., Husseini,W. K., Bertrand, C., Snider, R. M.,Desai, M. C. and Nadel, J. A.: Neu-nogenic vasodilation in the rat nasalmucosa involves neunokinin1 tachy-kinin receptors, 36

Pierce, G. N., Cole, W. C., Liu, K., Massaeli,H., Maddafond, T. G., Chen, Y. J.,McPherson, C. D., Jam, S. and Son-tag, D.: Modulation of cardiac per-formance by amilonide and severalselected derivatives of amilonide,1280

Pimozide, block of cyclic GMP-activatedcurrent, rod photoreceptors (frog),626

Pirenzepine, nicotinic antinociception, ad-nenengic, senotonergic and cholinengiccomponents (rats), 777

Plasma, stability and pharmacokinetics, na-diolabeled deferoxamine-biotin de-rivatives, 408

Platelet-derived growth factor, attenuation

of Ca� mobilization, isoflurane, vas-culan smooth muscle cells, 74

Plateletsblock of aggregation by 2-aminochno-

mones, inhibition of cAMP-depend-

ent phosphodiesterase (humans), 457pulmonary thromboembolism-induced a!-

terations, nitric oxide release, cincu-

lating neutrophi!s (rats), 1369

Polhuijs, M., Gasinska, I., Cherry, W. F.,Mulden, G. J. and Pang, K. S.: Ster-eose!ectivity in glutathione conjuga-

tion and amidase-catalyzed hydroly-sis of the 2-bromoisovalerylureaenantiomens in the single-pass per-

fused rat liver, 1406

Pollock, S. H., Reichbaum, M. I., Colbert,

J. C., Husain, P. A., Holbrook, J. M.,Ogonowski, A. A., Khlief, J. S. and

May, S. W.: The oral antihyperten-

sive activity of the methylated deny-

atives of phenyl-2-aminoethyl sul-

fide,1113Polosa, C., see Backman, S. B., 194

Polyamines

mechanism of putrescine transport, pul-monary artery endothelial cells (hu-man), 60

modulatory sites of NMDA receptors,

prevention of glutamate cytotoxicity,

ifenprodil (rats), 1017

Pompon, D., see Benson, A., 366

Pontecorvo, M. J., see Clissold, D. B., 876

Pontecorvo, M. J., see Karbon, E. W., 866

Poon, C. I., see Wang, Y.-X., 112

Ponreca, F., see Horan, P. J., 896, 1446Portoghese, P. S., see Miyamoto, Y., 1325

Pontoghese, P. S., see Negus, S. S., 1245Potassium

conductance, depression with barbiturateanesthetics, myocardium (frog), 358

differential actions of cisplatin, inner

medullany collecting ducts, renal

proximal tubule (rabbits), 1421

Potassium channel

action potential durations, minoxidil sul-fate-induced shortening, ventricularmyocytes (guinea pigs), 1527

Al-selective agonist RG14202 (pigs), 699

ATP-sensitive

blocker glibenclamide, no abolishment

of preconditioning (rats), 559cardioprotection with zofenopnil, myo-

candial ischemia (rats), 609

relaxation of coronary arteries, calci-

tonin gene-related peptide (pigs), 490

blocker glybunide, natniuretic properties

(rats), 933

delayed rectifier, inhibition by 2,3-buts-nedione monoxime, Xenopus oocytes,

1011differential effects of endothelin, gastric

longitudinal and circular smooth

muscle (rats), 1413

opener lemakalim, systemic, coronary andregional vascular dynamics (dogs),1026

Potts, A. A., see Martin, P. L., 201Poulsen, H. E., see Boesgaand, 5., 1239Prazosin, nicotinic antinociception, adre-

nengic, serotonergic and cholinengiccomponents (rats), 777

Preclamo!, electrophysiological effects, au-toneceptor-selective dopamine ago-

nists, AlO dopamine neurons (rats),963

Preconditioning, ATP-sensitive potassium

channel blocker, glibenclamide, is-chemic heart (rats), 559

Price, W. A., Jr., see Wong, P. C., 1088Pnisco, S., Cagnotto, A., Talone, D., De

Blasi, A., Mennini, T. and Esposito,E.: Tertatolol, a new fl-blocker, is aserotonin (5-hydroxytryptamine1�)

receptor antagonist in rat brain, 739Procainamide ethobromide, hepatobiliary

excretory function, chronic physicalactivity (rats), 321

Progesterone, mifepnistone and, responses

to oxytocin, circular myometnium

(rats), 1205

Propidium iodide, gastric mucosal gel thick-

ness, surface cell viability and pH,

effect of onogastnic nicotine (rats),

948Propranolo!

nicotinic antinociception, adrenergic, se-

rotonergic and cholinergic compo-

nents (rats), 777plasma concentration, f�l-b!ockade, dosing

rate-dependent relationship (hu-

mans), 681

prejunctional beta adrenoceptors, sympa-

thetic neurotnansmission, mesentery

(rats), 6574-Propyl-9-hydnoxynaphthoxazine, modifi-

cation of behavioral effects, dopa-mine antagonists (monkeys), 1039

Prostaglandin, differential regulation ofsynthesis, angiotensin peptides, aor-

tic smooth muscle cells (pigs), 664Proton, permeation, gastric mucosal gel

thickness, effect of orogastnic nic-

otine (rats), 948Proximal tubules

inner medullary collecting duct cells and,

differential actions, cisplatin (nab-bits), 1421

renal, cell death, extracellular acidosis(rabbits), 1355

Putrescine, mechanism of transport, pul-monany artery endothelial cells (hu-man), 60

Quattrochi, L. C., see Tassaneeyakul, W.,401

Quinapni!, vasoconstnictor activity, mesen-

tenic vasculatune (rats), 187Qumnuclidinyl benzi!ate, mu opiate receptor,

up-regulation by morphine, down-regulation by naloxone in neuno-blastoma cells (humans), 254

Radioimmunoimaging, radiolabeled defer-oxamine-biotin derivatives, plasmastability and pharmacokinetics, 408

Raiteni, M., see Bonanno, G., 765Ram, P. A., see Shapiro, B. H., 979

Rampe, D., Anderson, B., Rapien-Pryon, V.,Li, T. and Dage, R. C.: Comparison

of the in vitro and in vivo cardiovas-cular effects of two structurally dis-tinct Ca� channel activators, BAYK 8644 and FPL 64176, 1125

Rapien-Pryor, V., see Rampe, D., 1125Ravindranath, V., see Shivakuman, B. R.,

1137Raynon, K., Lucki, I. and Reisine, T.:

Somatostatin, receptors in the nu-

cleus accumbens selectively mediate

1562 Index

Rutter, J. J. and Auerbach, S. B.: Acuteuptake inhibition increases extracel-

the stimulatory effect of somato-

ststin on locomotor activity in rats,

67

Razdan, R. K., see Compton, D. R., 218Receptors

M-t5 complex, antinociceptive profile, bi-phalin (mice), 1446

adenosine A1antagonist N-0840, pharmacological

characterization, 227N-0861 and its enantiomers (guinea

pigs), 201

adenosine A2, discrimination in aorta andcoronary vessels, 2-pheny!ethoxy-9-methyladenine (guinea pigs), 248

angiotensinneuromodulatory effects, vas deferens

(rabbits), 601

prostaglandin synthesis, aortic smooth

muscle (pigs), 664angiotensin II, antagonist SR 47436,

pharmacological characterization(rats, dogs, monkeys), 826

benzodiazepine, ligands, hepatic enceph-alopathy (rats), 565

binding and in vivo activities, cannabi-noid structure-activity relationships

(rats), 218

chimenic kainate/NMDA, expression in

Xenopus oocytes, mammalian andamphibian RNA (rats), 910

cholinengic, microdialysis, l,2,3,4-tetnah-

ydroaminoacnidine (rats), 759

dopamine, autoreceptor-selective dopa-mine agonists, electrophysiologicaleffects (rats), 963

dopamine D1 and D2agonist potency and efficacy, MPTP-

induced hemipankinsonian monkeys,

1387motivational effects of opioids, neuro-

chemical substrates (rats), 53

occupation, antipsychotic drugs (rats),498

GABA, autoreceptors, cerebral cortex andspinal cord (rats), 765

GABAAinfluence of estrus cycle, neunostenoid

potency (rats), 1374neunochemical actions, inhalationa! an-

esthetics (mice), 1392GABAA-channel complex, characteriza-

tion, brain (rats), 985

GABAB, muscarinic m2 receptors, cere-bellan granule cells (rats), 433

gastnmn/cho!ecystokmnin-B, antagonist L-365,260, prevention of gastrointes-tinal damage (rats), 1348

5-HTagonists, neuronal circuits in discrimi-

native stimulus effects (rats), 572

serotonin-facilitated dopamine release(rats), 373

5-HT1Aeffect of spiperone, dorsal raphe and

hippocampus (rats), 7

pertussis and cholera toxins, dorsalraphe and hippocampus (rats), 16

5-HT1A and 5-HT1B, modulation, spinalnociceptive transmission (mice), 378

5-HT2occupation, antipsychotic drugs (rats),

498pharmacology, species differences

(rats), 1272

stress, peniventniculan hypophysial do-paminergic neurons (rats), 303

5-HT3 and 5-HT4, antagonist FK1052,pharmacological characterization

(rats, guinea pigs), 752

kainate, activation of nociceptive reflexes

(rats), 927N-methy!-D-aspartate

adaptive changes, imipramine and 1-

aminocyclopropanecarboxylic acidtreatment (mice), 1380

prevention of glutamate cytotoxicity by

ifenprodli, cortical neurons (rats),

1017

muscaninic, mechanism of bradycandia,

anticholinestenase neostigmine (cats),

194

muscaninic M2carbachol-induced sodium current, yen-

tnicular myocytes (guinea pigs), 641

short-term desensitization, cerebellar

granule cells (rats), 433

neurokinin, tachykinins and atnopine-ne-sistant motility, colon (guinea pigs),1224

neunokinin, tachykinin, neurogenic vaso-

dilation, nasal mucosa (rats), 36

neuromuscular junction, buffering hy-

pothesis, speed of action of muscle

nelaxants, 1181neuropeptide Y, constriction in femonal

artery rings, benextnamine protec-

tion studies (rats), 172

nicotinic acetylcholineagonist site, hippocampal neurons

(rats), 1474diversity, hippocampal neurons (rats),

1455ganglia-type, neuroblastoma clone line

(humans), 294

NPC 16377, binding, neurochemical and

neuroendocnine profile (rats, mice),

866octopamine, subtypes, octopaminengic ag-

onists (fireflies, hornwonms), 509opiate mu, down-regulation by morphine,

up-regulation by naloxone in neuro-

blastoma cells (humans), 254

opioid, regulation (mice), 314opioid delta, agonist and antagonist pro-

files, substituted deltorphins (mice),

896opioid delta-2, acute dependence on mor-

phine (mice), 1325

opioid mu

changes in renal function (rats), 134

cross-tolerance with alpha-2 adre-noceptors, spinal cord (rats), 551

supraspinal analgesic systems, geneti-cally different mouse strains, 166

supraspinal antinociception, N-acetyl�3-endorphin-(1--31) and substance P(mice), 835

opioid mu/delta/kappa, effect of antago-nists, reinforcing effects of heroin(rats), 1245

puninergic P2

human breast tumor cells, 1499pharmacological characterization, ne-

novascular system (rats), 334

somatostatin, locomotor activity, nucleusaccumbens (rats), 67

Reeves, M. L., see Torphy, T. J., 1213Reflex, nociceptive, activation, peripheral

kainate receptors (rats), 927

Vol. 265

Reichart, B., see Schwinger, R. H. G., 346Reichbaum, M. I., see Pollock, S. H., 1113Reinhardt-Maelicke, S., see Pereira, E. F.

R., 1474Reisine, T., see Raynor, K., 67Renfro, J. L., Brown, M. A., Parker, S. L.

and Hightower, L. E.: Relationshipof thermal and chemical tolerance totnansepithelial transport by culturedflounder rena! epithelium, 992

Renin-angiotensin system, vasoconstnictoractivity in mesentenic vasculature,quinapnil (rats), 187

Respiration, control of sympathetic nerve

activity, naloxone-precipitated mor-phine withdrawal (rats), 89

RG14202, Al-selective adenosine agonist

(pigs), 699

Rice, K. C., see Compton, D. R., 218

Riska, P., see Farina, P. R., 483Riva, M. A., see Longone, P., 441Rivera, L. M., see Merkel, L. A., 699RNA, mammalian and amphibian, chimenic

kainate/NMDA receptors, expres-sion in Xenopus oocytes (rats), 910

RNA, messenger, muscarinic m2, carbachol,cenebellar granule cells (rats), 441

Ro 41-1049, monoamine oxidase-A inhibi-

tons, dopamine metabolism, caudatus(rats), 103

Roache, J. D., see Gniffiths, R. R., 1163Robertson, D., see Tseng, C.-J., 1511Robertson, L. W., see Chaudhary, I. P., 1333Roccon, A., see Cazaubon, C., 826Rocuronium, speed of action, neuromuscu-

lan junction binding vs. buffering hy-pothesis, 1181

Rod, photoreceptors, block of cyclic GMP-activated current, pimozide (frog),626

Rodeheaver, D. P. and Schnellmann, R. G.:

Extnacellular acidosis amelioratesmetabolic-inhibitor-induced and p0-

tentiates oxidant-induced cell death

in renal proximal tubules, 1355

Roliprameffects of adenosine agonists, ventilation

(monkeys), 971-sensitive cyclic nucleotide phosphodies-

terases, cardiac microsomal fractions

(dogs, humans), 1142Romeo, E., see Auta, J., 649Roppolo, J. R., see Yoshiyama, M., 844

Roques, B. P., see Kalso, E. A., 551Roques, B. P., see Pham, I., 1339Rosebrough, S. F.: Plasma stability and

phanmacokinetics of nadiolabeled de-

fenoxamine-biotin derivatives, 408

Rosenzweig-Lipson, S. and Bergman, J.:Modification ofthe behavioral effectsof the selective dopamine D2 agonist(+)-4-pnopyl-9-hydroxynaphthoxa-zine by dopamine antagonists inmonkeys, 1039

Rotenone, cell death and extnacellular aci-dosis, renal proximal tubules (rab-bits), 1355

Rousseau, E., see Lugnien, C., 1142Rubidium-86, cromakalim-induced efflux,

inhibition by 8-(diethy!amino)-octy!-3,4,5-tnimethoxybenzoate, aorta (rats),

1399

1993 Index 1563

lular serotonin in the rat forebrain,1319

Sadeghi, H. M. and Eikenbung, D. C.: Issympathetic neunotnansmission inthe rat mesentery modulated by pre-junctional beta adrenoceptors?, 657

Sad!, V., see Tagani, P., 416

Salazan, L. A., see Cruz, S. L., 1519Salbutamol, prejunctional beta adnenocep-

tons, sympathetic neunotransmission,

mesentery (rats), 657Salt, -induced hypertension, prevention by

losartan, reduced renal mass rats,1131

S#{225}nchez-Bl#{225}zquez,P. and Garz#{243}n,J.: N-acetyl $-endorphin-(1-31) and sub-stance P regulate the supraspinal an-

tinociception mediated by mu opioidand alpha-2 adrenoceptors but not bydelta opioid receptors in the mouse,835

Sanguinetti, M. C., see Lynch, J. J., Jr., 720Sarcoplasmic reticulum, Ca� ATPase, in-

hibition of relaxation, nitroglycerinand atnial natniunetic factor (rabbits),1187

Sargent, C. A., see Grover, G. J., 559Sargent, C. A., Sleph, P. G., Dzwonczyk, S.,

Smith, M. A., Nonmandin, D., Anton-

accio, M. J. and Grover, G. J.: Car-

dioprotection in ischemic rat heartswith the SH-contsining angiotensin-

converting enzyme inhibitor zofeno-pnil: Possible involvement of the

adenosine tniphosphate-sensitive po-tassium channel, 609

Sasa, M., see Tamuna, Y., 1017Sathinakul, K., Suzuki, H., Yasuda, K., Han-

ano, M., Tagaya, 0., Hone, T. andSugiyama, Y.: Kinetic analysis ofhepatobiliany transport of organicanions in Eisai hypenbilirubinemic

mutant rats, 1301Sato, Y., see Tamuna, Y., 1017Sawaki, S., see Furukawa, Y., 801Schachten, M., see Calder, J. A., 1175Schindler, C. W., see Yasar, S., 1

Schizophreniaantipsychotic drugs, dopamine D1 and D2,

5-HT2 receptor occupation (rats), 498electrophysiological effects, autorecepton-

selective dopamine agonists, AlO do-

pamine neurons (rats), 963

NPC 16377 receptor binding, neurochem-ical and neunoendocrine profile (rats,mice), 866

Schmid, B., see Schwinger, R. H. G., 346Schmidt, U., see Schwinger, R. H. G., 346Schnellmann, R. G., see Rodeheaver, D. P.,

1355Schnattenho!z, A., see Pereina, E. F. R., 1474Schneiben, R. and de Vry, J.: Studies on the

neuronal circuits involved in the dis-criminative stimulus effects of 5-hy-droxytryptamine receptor agonists inthe nat,572

Schulz, C., see Schwingen, R. H. G., 346Schwam, E. M., see Gniffiths, R. R., 1163Schwartz, J. B., Troconiz, I. F., Verotta, D.,

Liu, S. and Capili, H.: Aging effectson stereoselective pharmacokinetics

and pharmacodynamics of venapamil,690

Schwinger, R. H. G., B#{246}hm,M., Schulz, C.,Schmidt, U., Schmid, B., Dienemann,

H., Reichart, B. and Endmann, E.:Cardiac inotnopic as well as coronaryand pulmonary actions of epinine inhuman isolated tissues, 346

Scopolamine, drugs of abuse and cholinergic

agents, delayed matching-to-sampleresponding (monkeys), 120

S-312-d, ischemic amino acid release and

neunonal injury, stroke-prone SHR

rats, 463

Secretin, somatostatin and, modulators of

electrolyte transport, gallbladder ep-

ithelium (guinea pigs), 273

Seizure, threshold, excitatory amino acids,antiepileptic drugs and chemoconvul-

sants (mice), 1063

Senda, T., see Matsuno, K., 851

Serik, C. M., see Lynch, J. J., Jr., 720Serotonin

extracellular, acute uptake inhibition,forebrain (rats), 1319

-facilitated dopamine release, pharmaco-logical characterization (rats), 373

halopenidol-induced catalepsy (rats), 2075-HT3 receptor-mediated ion current,

tnich!onoethano!potentiation, nodoseganglion neurons (rats), 771

microinjection into nucleus naphe obscu-

rus, increased intragastnic pressure,vagal mediation (rats), 468

NPC 16377 receptor binding, neunochem-

ical and neuroendocnine profile (rats,

mice), 866short-term effects, MDMA metabolites

(rats), 813

vasoconstnicton activity in mesentenicvasculatune, quinapnil (rats), 187

Seven, P. 5., see Calden, J. A., 1175

Seven, P. 5., see Garcha, R. S., 860

Seyama, I., see Yakehiro, M., 1328Shaffen, J. E., Grizzle, M. K., Anderson, D.

K. and Wheeler, T. N.: The inotnopicand beta blocking effects of a chi-

menic molecule that putatively inhib-its both type III phosphodiestenaseand beta adrenoceptons in anesthe-

tized dogs, 1105

Shapiro, B. H., Pamponi, N. A., Ram, P. A.and Waxman, D. J.: Irreversiblesuppression of growth honmone-de-

pendent cytochrome P450 2C11 inadult rats neonatally treated withmonosodium glutamate, 979

Sharp, T., see Hjorth, S., 707Shaw, L., see Kurth, C. D., 587Shen, Y.-T. and Vatner, S. F.: Effects of a

K�ATP channel opener, lemakalim, on

systemic, coronary and regional vas-cular dynamics in conscious dogs:Comparison with nifedipine, adeno-sine, nitroglycerin, and acety!cho!ine,1026

Sheng, J., see Domino, E. F., 1387Shippenbeng, T. S., Bals-Kubik, R. and

Henz, A.: Examination of the neuno-chemical substrates mediating themotivational effects of opioids: Roleof the mesolimbic dopamine systemand D- 1 vs. D-2 dopamine receptors,53

Shinayama, T., Matsumoto, K. and Pap-pano, A. J.: Carbachol-induced so-

dium current in guinea pig ventricu-lar myocytes is not regulated byguanine nucleotides, 641

Shivakumar, B. R. and Ravindranath, V.:Oxidative stress and thiol modifica-tion induced by chronic administra-

tion of halopenido!, 1137

Shock, bacterial !ipopo!ysaccharide, induc-tion of nitric oxide synthase, inhibi-

tion by nifedipine (mice), 674

Shryock, J., see Dennis, D. M., 543Signal transduction

inhibition of paniets! cell function, epi-

dermal growth factor, TGF-a (nab-bits), 308

thromboxane A2, vascular smooth muscle(rats), 447

Sill, J. C., Eskuni, S., Nelson, R., Tarara, J.and Van Dyke, R. A.: The volatileanesthetic isoflunane attenuates Ca�mobilizaton in cultured vascularsmooth muscle cells, 74

Simon, R. P., Chen, J. and Graham, S. H.:GM1 treatment of focal ischemia: Adose-response and microdialysis

study, 24SKF-38393, involvement of brain dopa-

mine, behavioral action of MK-80l,

6-hydnoxydopamine-lesioned rats,

1001Skolnick, P., see Harris, B., 1392

Skolnick, P., see Nowak, G., 1380Slaninova, J., see Honan, P. J., 1446Sleph, P. G., see Grover, G. J., 559Sleph, P. G., see Sargent, C. A., 609Sloan, J. W., Martin, W. R. and Wala, E.:

Effect of the chronic dose of diaze-pam on the intensity and character-istics of the precipitated abstinencesyndrome in the dog, 1152

Smallwood, V. V., see Va!eyev, A. Y., 985

Smith, D. J., see Urban, M. 0., 580

Smith, J. E., see Goeders, N. E., 592Smith, M. A., see Sargent, C. A., 609

Smith, M. P., see Clark, M. A., 933Smith, R. D., see Wong, P. C., 1088Smits, G. J., see Menkel, L. A., 699

Snider, R. M., see Piedimonte, G., 36Sodium, natniunetic properties, glybunide

(rats), 933Sodium channel, structure-activity relation-

ship, D-ning derivatives, grayano-

toxin (squid), 1328Sodium current, canbachol-induced, ventnic-

ular myocytes, guanine nucleotides(guinea pigs), 641

Sodium fluxes, modulators of electrolyte

transport, secretin and somatostatin,

gallbladder epithelium (guinea pigs),273

Sodium nitroprusside, endothelium-de-

pendent relaxation of aorta, L- andD-enantiomers, NG�nitno�arginine

(rats), 112

Sodium-potassium adenosine tniphospha-

tsse, differential actions of cisplatin,inner medullary collecting ducts,renal proximal tubule (rabbits), 1421

Sokol, P. P., Longenecken, K. L., Kache!, D.

L. and Martin, W. J., II: Mechanismof putrescine transport in human pul-monary artery endothelial cells, 60

Somatostatin, secretin and, modulators ofelectrolyte transport, gallbladder ep-ithelium (guinea pigs), 273

Someya, K., see Takahashi, H., 681Sontag, D., see Pierce, G. N., 1280

1564 Index

Species differences, pharmacology of 5-HT2receptor (rats), 1272

Sphincter, urethral, involvement of nitricoxide, inhibitory control (rats), 713

Spinal cord

activation of nociceptive reflexes, peniph-

era! kainate receptors (rats), 927cerebral cortex and, GABA autoneceptons,

receptor subtypes (rats), 765cross-tolerance, mu opioid and alpha-2

adrenengic receptors (rats), 551

modulation of kainic acid-induced activ-

ity, amino terminus of substance P

(mice), 159Spine, nociceptive transmission, modula-

tion, 5-HT1A and 5-HTIB receptorsubtypes (mice), 378

Spipenone, differential properties of 5-HT1A

receptors, dorsal raphe and hippo-campus (rats), 7

Splenocytes, gallium arsenide-inducedsuppression, antibody-forming cell

response, reversal by vehicle super-

natants (mice), 144, 150

Spnakties, G., Macherey, H. J. and Petersen,

K-U.: Secretin and somatostatin as

modulators of electrolyte transport in

guinea pig gallbladder epithelium,273

SR 47436, pharmacological characterization

(rats, dogs, monkeys), 826

Snima!, R. C., see Dikshit, M., 1369ST-91, alpha-2 adrenoceptor-mediated an-

tinociception, cholinergic interaction

(sheep), 536Statkevich, P., Fournien, D. J. and Sweeney,

K. R.: Characterization of metho-trexate elimination and interactionwith indomethacin and flunbiprofen

in the isolated perfused rat kidney,1118

Stein, R. B., see Lynch, J. J., Jr., 720

Steppuhn, K. G. and Tunski, L.: Modulationof the seizure threshold of excitatory

amino acids in mice by antiepileptic

drugs and chemoconvulsants, 1063

Stomach, anti-inflammatory-histamine H2

antagonist drug complex, gastric ero-sions (rats), 328

Stonnetta, R. L., see Baraban, S. C., 89St.-Pienne, M. V. and Pang, K. S.: Kinetics

of sequential metabolism. II. Forma-tion and metabolism of nondiazepamand oxazepam from diazepam in theperfused munine liver, 1437

St-Pierre, M. V. and Pang, K. S.: Kineticsof sequential metabolism. I. Forma-

tion and metabolism of oxazepam

from nordiazepam and temazepam inthe perfused munine liver, 1429

Stneptsvidin, radiolabeled defenoxamine-biotin derivatives, plasma stabilityand phanmacokinetics, 408

Streptococcus pneumoniae, inhibition ofbacterial growth, gallium arsenide-

exposed mice, arsenic in sena, 795Stniatum, extracellular concentration of

acetylcholine, microdialysis, 1,2,3,4-tetnahydroaminoacnidine (rats), 759

Strobel, H. W., see Ahmed, S. S., 1047Stroke

GM1 treatment of focal ischemia (rats),24

-prone SHR rats, effects of S-3l2-d, is-

chemic amino acid release and neu-

ronal injury, 463Stupienski, R. F., see Lynch, J. J., Jr., 720Suberyldicholine, diversity of nicotinic ace-

tylcholine receptors, hippocampalneurons (rats),1455

Substance PN-acetyl fl-endorphin-(l-31) and, supna-

spinal antinociception, mu opioid

and alpha-2 adrenoceptons (mice),835

amino terminus, modulation of kainicacid-induced activity, spinal cord

(mice), 159

neurogenic vasodilation, neurokinin1 ta-

chykinin receptors, nasal mucosa(rats), 36

Substrate, inhibitor probes and, cyto-chromes P450 1A1 and 1A2 (hu-

mans), 401

Sugiyama, Y., see Sathinakul, K., 1301

Sulfate, thermal and chemical tolerance,

transepithelial transport, renal epi-

thelium (flounder), 992Sulfhydryl groups, substituted deltorphins,

opioid delta receptor multiplicity(mice), 896

Sulfonylureas, natniunetic properties, gly-bunide (rats), 933

Sullivan, A. F., see Kalso, E. A., 551Sun, X., see Larson, A. A., 159Sutton, S. C., see Lecluyse, E. L., 955

Suzuki, H., see Sathinakul, K., 1301Sweeney, K. R., see Statkevich, P., 1118

Sweetsna-Grass diffusion cells, permeabil-ity and morphology, colonic mucosa,long-chain acylcarnitines (rats), 955

Sykes, A. M., see Martin, P. L., 201Sympathetic nervous system

brain stem mechanisms, effects of nic-otine, cardiovascular control (rats),

1511

constriction of cerebral arterioles, cocaineand its metabolites (piglets), 587

functional characterization, alpha adne-

noceptons, intnarenal arteries (nab-bits), 807

functional integrity, pressor and tachy-

cardiac effects, diphenyleneiodonium

(rats), 263

respiratory control, naloxone-precipi-

tated morphine withdrawal (rats), 89Synaptosomes, GABA autoreceptors, cere-

bra! cortex and spinal cord (rats), 765

Szab#{244},C., Mitchell, J. A., Gross, S. S., Thie-mermann, C. and Vane, J. R.: Nife-

dipine inhibits the induction of nitric

oxide synthase by bacterial lipopoly-sacchanide, 674

Szelenyi, I.,see Yasar, 5., 1

Tachycardia, diphenyleneiodonium, func-

tional integrity, CNS and sympa-

thetic nervous system (rats), 263

Tachykinins, neflexly evoked atnopine-re-

sistant motility, colon (guinea pigs),1224

Tagani, P., Becker, A., Bnideau, C., Fnenette,R., Sad!, V., Thomas, E., Vickers, P.,

and Ford-Hutchinson, A.: Leuko-

tniene generation and metabolism in

dogs: Inhibition of biosynthesis byMK-0591, 416

Tagaya, 0., see Sathirakul, K., 1301

Taira, N., see Kageyama, M., 490Takahashi, H., Ogats, H., Kashiwada, K.,

Vol. 265

Ohina, M. and Someya, K.: Dosingrate-dependent relationship between

propranolol plasma concentration

and �3-blockade, 681Takanashi, M., see Kohi, M., 1292Takaoni, S., see Tamuna, Y., 1017Takayama, S., see Funukawa, Y., 801Takemoni, A. E., see Miyamoto, Y., 1325Takemoni, A. E., see Negus, S. S., 1245Tallant, E. A., see Jaiswal, N., 664Talone, D., see Pnisco, S., 739Tamuna, Y., Sato, Y., Yokota, T., Akaike,

A., Sasa, M. and Takaoni, S.: Ifenpro-dil prevents glutamate cytotoxicityvia polyamine modulatory sites of N-methyl-D-aspartate receptors in cul-tuned cortical neurons, 1017

Tarara, J., see Sill, J. C., 74

Tassaneeyakul, W., Binkett, D. J., Venonese,

M. E., McManus, M. E., Tukey, R.H., Quattrochi, L. C., Gelboin, H. V.and Miners, J. 0.: Specificity of sub-

strate and inhibitor probes for hu-man cytochnomes P450 lAl and 1A2,

401

Taurocholate, chronic physical activity,

hepatobiliary excretory function(rats), 321

Taylor, D. G., Jr., see Major, T. C., 187T cells, inhibition ofpnolifenation by gallium

arsenide, altered CD25 expression

(mice), 178Temazepam, nondiazepam and, formation

and metabolism of oxazepam, liven(mice), 1429, 1437

Tertatolo!, 5-HT1A receptor antagonist,brain (rats), 739

Tessel, R. E., Miller, D. W., Misse, G. A.,Dong, X. and Doughty, M. B.: Char-actenization of vascular postsynapticneuropeptide Y receptor function andregulation. 1. NPY-induced constnic-

tion in isolated rat femonal arteryrings is mediated by both Y1 and Y2receptors: Evidence from benextra-

mine protection studies, 172

Testosterone 2a-hydroxy!ase, growth hor-

mone-dependent cytochrome P4502Ci 1, irreversible suppression, mon-osodium glutamate (rats), 979

l,2,3,4-Tetrahydno-9-aminoacnidine, micro-

dialysis, extracellular concentrationof acetylcholine, striatum (rats), 759

Tetrodotoxin, monoamine oxidase-A inhib-itons, dopamine metabolism, cauda-tus (rats),103

Thapsigargin, attenuation of Ca� mobili-zation, isoflunane, vascular smoothmuscle cells, 74

Thermotolenance, chemical tolerance and,transepithelial transport, renal epi-

thelium (flounder), 992

Thiazide, diuretics, acute vascular effects,

ion channel involvement (guineapigs), 1175

Thiemermann, C., see Szab#{243},C., 674Thiol, modification, oxidative stress,

chronic haloperidol administration(rats), 1137

Thiopentsl, barbiturate anesthetics, depres-

sion of resting K� conductance, myo-cardium (frog), 358

Thomas, E., see Tagani, P., 416Thonndike, E. B., see Yasar, 5., 1Thromboembolism, pulmonary, alterations

1993 Index 1565

in nitric oxide release, circulating

neutrophils (rats), 1369Thnomboxane A2, stimulated signal trans-

duction, vascular smooth muscle(rats), 447

Thymocytes, subpopulations, morphine-in-duced alterations (mice), 81

Timmenmans, P. B. M. W. M., see Wong,P. C., 1088

Timolo!, sensitization of GABA-induceddepressions, cerebellar Purkinje neu-rons, beta adrenergic mechanisms

and ethanol (rats), 426

Tirapazamine, pharmacokinetics and bio-reductive metabolism (mice), 938

Tokoro, K., see Nagakuna, Y., 752Tolerance, induction of, crotoxin (mice), 41Tomoi, M., see Nagakura, Y., 752Tong, C., see Detweilen, D. J., 536Torphy, T. J., Undem, B. J., Cieslinski, L.

B., Luttmann, M. A., Reeves, M. L.and Hay, D. W. P.: Identification,characterization and functional roleof phosphodiestenase isozymes in hu-

man airway smooth muscle, 1213

Transforming growth factor-a, epidermalgrowth factor and, inhibition of pa-nietal cell function (rabbits), 308

Tnichloroethanol, potentiation of 5-HT3 re-ceptor-mediated ion current, nodoseganglion neurons (rats), 771

2, 4, 6-Triethyl-phenyl(imino)imidazolidine,

2,4,6-tnimethyl-pheny!(imino)

imidazolidine and, octopaminergicagonists, octopamine receptor sub-

types (fireflies, hornwonms), 509Tnifluoperazine, mitochondrial and glyco-

lytic dysfunction, lethal injury to he-

patocytes (rats), 392

2,4,5-Tnihydroxyamphetamine, 2,4,5-tnihy-droxymethamphetamine and, centraltryptophan hydroxylase activity

(rats), 813

Tnoconiz, I. F., see Schwartz, J. B., 690

Trullas, R., see Nowak, G., 1380

Tryptamines, species differences in phar-

macology, 5-HT2 receptor (rats),1272

Tryptophan hydroxylase, central activity,short-term effects, MDMA metabo-

lites (rats), 813

Tseng, C.-J., Appalsamy, M., Robertson, D.and Mosqueda-Garcia, R.: Effects ofnicotine on brain stem mechanismsof cardiovascular control, 1511

Tsuzuki, K., see Im, H. K., 529

D-Tubocuronium, speed of action, neuro-muscular junction binding vs. buff-

ering hypothesis, 1181

Tukey, R. H., see Tassaneeyaku!, W., 401

Tuntaterdtum, S., see Chaudhary, I. P., 1333Turski, L., see Steppuhn, K. G., 1063

Tyramine, endothelium- and beta-2 adre-noceptor-independent relaxation,aorta (rats), 1096

U-50,488H, medullary hyperalgesic center,pharmacological characteristics(rats), 286

U-88,779E, block of transient calcium chan-

nel current, neunoblastoma cells

(mice), 529Ueda, I., see Imai, T., 328Ueda, M., see Gemba, T., 463Ueeda, M., see Martin, P. L., 248Uejima, Y., Kokubo, M., Oshida, J.-I., Ka-

wabata, H., Kato, Y. and Fujii, K.: 5-Methyl-4H-3,l-benzoxazin-4-one de-

nivatives: Specific inhibitors of hu-

man leukocyte elastase, 516

UL-FS 49, increased atnial force and de-creased ventricular force, heart prep-

arations (dogs), 801Undem, B. J., see Torphy, T. J., 1213

Urban, M. 0. and Smith, D. J.: Role of

neunotensin in the nucleus naphemagnus in opioid-induced antinoci-ception from the peniaqueductal gray,

580

Urethra, external sphincter, involvement of

nitric oxide, inhibitory control (rats),713

Usherwood, P. N. R., see Bnakcley, P. T. H.,

910Uyehara, C. F. T., see Pichoff, B. E., 524

Vagus nerve, senotonin microinjection intonucleus raphe obscurus, increased in-

tragastnic pressure (rats), 468

Valentine, J. L., see Owens, S. M., 1261

Valeyev, A. Y., Barker, J. L., Cruciani, R.

A., Lange, G. D., Sma!lwood, V. V.and Mahan, L. C.: Characterizationofthe -y-aminobutynic acidA receptor-channel complex composed of a1fl2

and a1fl3 subunits from rat brain, 985Van den Gaag, L. H., see Lynch, J. J., Jr.,

720Vandenmeersch, S., see Chansel, D., 1534Van Dyke, R. A., see Sill, J. C., 74

Vane, J. R., see Szab#{243},C., 674

Van Rijn, H. J. M., see Bijlsma, J. A., 1267Varma, D. R. and Chemtob, S.: Endothe-

hum- and beta-2 adrenocepton-inde-

pendent relaxation of rat aorta by

tyramine and certain other phenyl-ethylamines, 1096

Vascular permeability, tissue injury, inhibi-

tion of vascular leakage, neurotensinpeptides (rats), 619

Vascular resistance, comparison of vasodi-lators, lemakalim (dogs), 1026

Vasculatunemesentenic, vasoconstnictor activity, qui-

napnil (rats), 187sympathetic vasomotor control, postjunc-

tional role, neuropeptide Y (rabbits),887

Vas deferenselectrically induced contractile responses,

inhibition of puninengic component,atnial natniuretic peptide (guineapigs), 920

neuromodulatory effects of angiotensin,angiotensin receptors (rabbits), 601

Vasoconstnictionfunctional characterization, alpha adre-

noceptors, intrarenal arteries (rab-

bits), 807

quinapnil, activity in mesentenic vascula-

tune (rats), 187

vascular postsynaptic neunopeptide Y re-

ceptor function (rats), 172Vasodilation

antiprolifenative and endothelium-de-

pendent, l,3-dihydro-3-p-chlono-

phenyl-7-hydroxy-6-methyl-furo-(3,4c) pyridine hydrochloride (rats), 30

Al-selective agonist RG14202 (pigs), 699

neunogenic

neurokinin1 tachykinin receptors, nasal

mucosa (rats), 36

role ofnitnic oxide, cerebral artery (pig),339

Vasopnessin, attenuation of Ca� mobiliza-

tion, isoflunane, vascular smooth

muscle cells, 74Vasorelaxation, ion channel involvement,

acute vascular effects, thiazide di-uretics (guinea pigs), 1175

Vatner, S. F., see Shen, Y.-T., 1026

Vecuronium, speed of action, neunomuscu-

lar junction binding vs. buffering hy-

pothesis, 1181Venkova, K. M., see Mutafova-Yambolieva,

V. N., 920Ventilation, effects of adenosine agonists

(monkeys), 971

Ventral stniatum, induction of feeding,opioid stimulation (rats), 1253

Ventral tegmental area, electnophysiologica!

effects, autoneceptor-selective dopa-

mine agonists, AlO dopamine neu-nons (rats), 963

Ventricle, decreased force, increased atnial

force, UL-FS 49 (dogs), 801Verapamil

action of am!odipine, subcutaneous resist-

ance arteries (humans), 860stereoselective pharmacokinetics and

pharmacodynamics, aging effects(humans), 690

Veronese, M. E., see Tassaneeyaku!, W., 401Venotts, D., see Schwartz, J. B., 690Venschoyle, R. D., Dinsdale, D. and Wolf,

C. R.: Inhibition and induction ofcytochnome P450 isoenzymes in rat

lung, 386

Vickens, P., see Tagani, P., 416Vidal, J. C., see Okamoto, M., 41Villanreal, J. E., see Crux, S. L., 128, 1519

Viskatis, L. J., see Okamoto, M., 41Voltage clamp

barbiturate anesthetics, depression ofresting K� conductance, myocandium

(frog), 358

chimenic kainate/NMDA receptors,expression in Xenopus oocytes, mam-

malian and amphibian RNA (rats),910

Wainscott, D. B., see Nelson, D. L., 1272Wala, E., see Sloan, J. W., 1152

Wallace, A. A., see Lynch, J. J., Jr., 720Walton, M. I. and Workman, P.: Phanma-

cokinetics and bioneductive metabo-

lism of the novel benzotniazine di-N-oxide hypoxic cell cytotoxin tirapa-zamine (WIN 59075; SR 4233; NSC130181) in mice, 938

Waltzing syndrome, region-dependent dam-

age to central nervous system, levelsabove brain stem, 3,3’-iminodipno-pionitnile (rats), 1492

Wang, F. S. and Fujimoto, J. M.: Pentoban-bital administered intracerebroven-tnicularly antagonizes morphine-in-

duced antinociception in mice, 1361Wang, L., Lucey, M. R., Fras, A. M., Wilson,

E. J. and Del Valle, J.: Epidenmalgrowth factor and transforminggrowth factor-a directly inhibit pan-etsl cell function through a similarmechanism, 308

Wang, Y.-X., Poon, C. I. and Pang, C. C.Y.: In vitro and ex vivo inhibitoryeffects of L and D-enantiomens of �

1566 Index Vol. 265

nitro-anginine on endothelium-de-pendent relaxation of rat aorta, 112

Wang, Y.-X. and Pang, C. C. Y.: Functionalintegrity of the central and sympa-thetic nervous systems is a prerequi-site for pressor and tachycardic ef-fects of dipheny!eneiodonium, anovel inhibitor of nitric oxide syn-thase, 263

Watanabe, K., see Hone, S., 1313

Watkins, J. B., III, see Yiamouyiannis, C.A., 321

Watts, V. J., see Lysle, D. T., 1071Waxman, D. J., see Shapiro, B. H., 979Weber, S., see Horan, P. J., 1446

Weber, S. J., see Horan, P. J., 896Wegner, C. D., see Farina, P. R., 483Wei, E. T., see Gao, G. C., 619Weinger, M. B., see Negus, S. S., 1245Welch, S. P.: Blockade of cannabinoid-in-

duced antinociception by nonbina!-torphimine, but not N,N-dial!yl-tryosine-aib-phenylalanine-leucineIC! 174,864 or naloxone in mice, 633

Wenger, G. R., see Hudzik, T. J., 120Wexler, R. R., see Wong, P. C., 1088Wheeler, T. N., see Shaffer, J. E., 1105White, D. A., see Fleming, N. W., 1199White, F. J., see Ackerman, J. M., 963Wientjes, M. G., see Bramer, S. L., 731Wilcox, G. L., see Alhaiden, A. A., 378

Wild, K. D., see Horan, P. J.,896Willets, J., Clissold, D. B., Hantman, T. L.,

Brandsgaard, R. R., Hamilton, G. S.

and Ferkany, J. W.: Behavioral phar-macology of NPC 17742, a competi-tive N-methyl-D-aspartate (NMDA)antagonist, 1055

Wilson, E. J., see Wang, L., 308Winer, N., see El Alj, A., 1205

Wishka, D. G., see Benjamin, C. W., 457Wojcik, W. J., see Contrera, J. G., 433Wojcik, W. J., see Longone, P., 441

Wolf, C., see Benson, A., 366Wolf, C. R., see Verschoyle, R. D., 386

Wong, G., see Harris, B., 1392

Wong, P. C., Aldrich, P. E., Chiu, A. T.,Earl, R. A., Hart, S. D., Johnson, A.

L., Ma, P., McCall, D. E., Price, W.A., Jr., Smith, R. D., Wexler, R. R.and Timmermans, P. B. M. W. M.:Pharmacology of 2-amino-1,4-dihy-

dro-4-(2-�4-[4-(2-methoxypheny!)-1-

piperazinyl]buty!sulfinyflphenyl)-6-

methyl-5-nitno-3-pynidine carboxylicacid methyl ester (XB513), a novel

calcium agonist with alpha-i adre-nergic receptor antagonistic prop-erty, 1088

Workman, P., see Walton, M. I., 938Wyche, J. H., see Han, Z., 790

XB513, pharmacology (rats), 1088Xenopsin, inhibition of vascular leakage,

tissue injury (rats), 619Xiao, W.-B., Nordberg, A. and Zhang, X.:

Effect of in vivo microdialysis of 1,2,3,4-tetrahydro-9-aminoacnidine(THA) on the extracellular concen-tration of acetylcho!ine in the stnia-turn of anesthetized rats, 759

Xu, J., see Contrera, J. G., 433

Xue, H., see Bukoski, R. D., 30

Yakehiro, M., Yamamoto, S., Baba, N., Na-kajima, S., Iwasa, J. and Seyama, I.:Structure-activity relationship forD-ring derivatives of grayanotoxin inthe squid giant axon, 1328

Yamamoto, S., see Yakehiro, M., 1328Yamamuna, H. I.,see Horan, P. J., 896, 1446Yamashita, I.,see Matsubana, S., 498

Yanagisawa, T., see Kageyama, M., 490Yano, S., see Hone, S., 1313

Yasar, S., Schindler, C. W., Thorndike, E.B., Szelenyi, I. and Goldberg, S. R.:Evaluation of the stereoisomers of

deprenyl for amphetamine-like dis-cniminative stimulus effects in rats, 1

Yasuda, K., see Sathirakul, K., 1301

Yiamouyiannis, C. A., Martin, B. J. and

Watkins, J. B., III: Chronic physicalactivity alters hepatobiliary excne-tory function in rats, 321

Yoburn, B. C., Billings, B. and Duttanoy, A.:Opioid receptor regulation in mice,314

Yokota, T., see Tamura, Y., 1017Yoshiyama, M., Roppolo, J. R. and de Groat,

W. C.: Effects of MK-80l on the mic-tunition reflex in the rat-possiblesites of action, 844

Young, M. B., see Lynch, J. J., Jr., 720Yurdaydin, C., Gu, Z.-Q., Nowak, G.,

Fromm, C., Holt, A. G. and Basile, A.S.: Benzodiazepine receptor ligandsare elevated in an animal model ofhepatic encephalopathy: Relation-ship between brain concentrationand severity of encephalopathy, 565

Zacopride, nicotinic antinociception, adre-nergic, senotonengic and cholinergiccomponents (rats), 777

Zadina, J. E., Chang, S. L., Ge, L.-J. andKastin, A. J.: Mu opiate receptordown-regulation by morphine and

up-regulation by naloxone in SH-SY5Y human neuroblastoma cells,254

Zajac, J. M., see Million, M., 96Zeidel, M. L., see Brady, H. R., 1421Zhang, X., see Xiao, W.-B., 759Zhou, Q., see Lovinger, D. M., 771Zinc, thermal and chemical tolerance, trans-

epithelial transport, renal epithelium(flounder), 992

Zingaro, G. J., see Lynch, J. J., Jr., 720Zofenopni!, cardioprotection, myocandial is-

chemia, ATP-sensitive potassium

channel (rats), 609