General Information:

FALK FOUNDATION e.V.Leinenweberstr. 579108 FreiburgGermany

Congress DepartmentTelephone: +49(0)761/1514-0Telefax: +49(0)761/1514-359E-Mail: symposia@falkfoundation.dewww.falkfoundation.org

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Preliminary Program

Falk Symposium 199

Highlights from Hepatology 2015: From Chronic Hepatitis to Hepatocellular Carcinoma

October 14 15, 2015Konzerthaus FreiburgFreiburg, Germany

Application for CME credits submitted

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3Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4

Scientific Program . . . . . . . . . . . . . . . . . . . . . . . . . . 6

Posters . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10

List of Speakers, Moderators and Scientific Organizers . . . . . . . . . . . . . . . . . . . . . . . . 11

Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14

CME credits for the Falk Symposium 199 have been applied for at the European Union of Medical Specialists (UEMS) European Board of Gastroenterology (EBG) . The number of credits awarded will be printed in the final program .

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4Preface

Dear colleagues, dear friends,

On behalf of the scientific organizers, Olivier Chazouillres, Josep M . Llovet, Darius Moradpour and myself, I would like to cordially invite you to the Falk Symposium 199 entitled High-lights from Hepatology 2015 . At that meeting, internationally leading experts of their respective fields will provide an update on current state-of-the-art and novel developments in Hepatology . Topics range from acute and chronic viral hepatitis, autoimmune liver disease, alcoholic and metabolic liver disease, liver cirrhosis and its complications to liver cancer .

In the tradition of the successful Falk Symposia, the program combines basic science with clinical relevant aspects . Thus, this translational update on pathogenesis, diagnosis and treatment therapy of the most important and clinical relevant liver diseases will be of interest to both, clinicians and scientists .

A special invitation is extended to young clinician scientists who can present their work in the poster sessions and will surely benefit from fruitful discussions .

We are looking forward to welcoming you for two days of excellent presentations, interesting discussions and social contacts in the wonderful city of Freiburg in the Black Forest .

With best wishes on behalf of the scientific organizers,

Robert Thimme, Freiburg

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Falk Symposium 199

Highlights from Hepatology 2015: From Chronic Hepatitis to Hepatocellular Carcinoma

October 14 15, 2015Konzerthaus FreiburgFreiburg, Germany

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Registration:Tuesday, October 13, 201516 .00 21 .00 hat the congress office

Scientific Organization:O . Chazouillres, Paris (France)J . M . Llovet, Barcelona (Spain) D . Moradpour, Lausanne (Switzerland)R . Thimme, Freiburg (Germany)

Congress Venue:Konzerthaus FreiburgKonrad-Adenauer-Platz 179098 FreiburgGermany

Information:Prof . Dr . Robert ThimmeInnere Medizin IIUniversittsklinikum FreiburgHugstetter Str . 5579106 FreiburgGermanyTelephone: +49 (0) 761 / 27 03 28 00Telefax: +49 (0) 761 / 27 03 61 00E-Mail: robert .thimme@

uniklinik-freiburg .de

Official Language:English . Simultaneous translation into German .

Posters:For details see page 10

Publication Date of the Final Program: October 2015

The final program will be available on the homepage www .falkfoundation .org one week before .

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6Wednesday, October 14, 2015

9.00 Welcome R . Thimme, Freiburg

Session I Viral hepatitis I

Chair: D . Moradpour, Lausanne; R . Thimme, Freiburg

9.10 History and global burden of viral hepatitis H . E . Blum, Freiburg

9.35 Hepatitis B: From molecular virology to new antiviral F . Zoulim, therapies Lyon

10.00 Hepatitis C in the era of direct antiviral therapies D . Moradpour, Lausanne

10.25 Coffee break with poster session

Session II Viral hepatitis II

Chair: D . Moradpour, Lausanne; R . Thimme, Freiburg

10.55 Chronic hepatitis D: At a stand still? M . Rizzetto, Turin

11.20 Hepatitis E virus: Time to change the textbooks! H . R . Dalton, Truro

11.45 Challenges in special populations: Co-infection, liver X . Forns, transplantation etc . Barcelona

12.10 Lunch break with poster session

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7Wednesday, October 14, 2015

Session III Autoimmune liver disease

Chair: O . Chazouillres, Paris; A . W . Lohse, Hamburg

13.30 Pathogenesis of autoimmune and cholestatic liver diseases G . Hirschfield, Birmingham

13.55 Autoimmune hepatitis C . P . Strassburg, Bonn

14.20 Overlap syndromes: Classification, diagnosis and A . W . Lohse, management Hamburg

14.45 Novel aspects in the management of cholestatic liver O . Chazouillres, diseases Paris

15.10 Coffee break with poster session

Session IV Alcoholic and metabolic liver disease

Chair: R . Bataller, Chapel Hill; A . Geier, Wuerzburg

15.40 Pathogenesis and management of alcoholic liver disease R . Bataller, Chapel Hill

16.05 NASH: From pathogenesis to novel therapies A . Geier, Wuerzburg

16.30 Hereditary hemochromatosis: Pathogenesis, diagnosis H . Zoller, and treatment Innsbruck

16.45 End of afternoon session

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8Thursday, October 15, 2015

Session V Liver cirrhosis and its complications

Chair: A . L . Gerbes, Munich; M . Rssle, Freiburg

9.00 Development and reversion of cirrhosis M . Pinzani, London

9.30 Current management of the complications of cirrhosis G . Garcia-Tsao, and portal hypertension: variceal hemorrhage, ascites, New Haven and spontaneous bacterial peritonitis .

10.00 Liver cirrhosis and kidney A . L . Gerbes, Munich

10.30 Coffee break with poster session

Session VI From basic science to the clinic

Chair: F . Lammert, Homburg; G . Perlemuter, Paris

11.00 Microbiota and liver disease G . Perlemuter, Paris

11.25 Genetics in liver disease F . Lammert, Homburg

11.50 Immune responses in viral hepatitis C . Neumann-Haefelin, Freiburg

12.15 Liver fibrosis: from pathogenesis to novel therapies F . Tacke, Aachen

12.40 Acute liver failure A . E . Canbay, Essen

13.05 Lunch break with poster session

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9Thursday, October 15, 2015

Session VII Liver cancer: molecular pathogenesis and treatment

Chair: P . R . Galle, Mainz; J . M . Llovet, Barcelona

14.00 Presentation of Poster Prizes R . Thimme, Freiburg

14.10 Molecular pathogenesis and novel drivers J . Zucman-Rossi, Paris

14.40 Role of immunity in pathogenesis and treatment R . Thimme, of HCC Freiburg

15.10 Management of liver cancer P . R . Galle, Mainz

15.40 From emerging phase I to failing III phase trials J . M . Llovet, Barcelona

16.10 Coffee break with poster session

16.40 Assessment / response in HCC R . Lencioni, Pisa

17.10 Molecular pathogenesis and treatment of ICC G . J . Gores, Rochester

17.40 Surgical treatment of HCC and ICC P . E . Majno, Geneva

18.10 End of the meeting

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Poster SessionPosters will be exhibited on October 14-15, 2015 in the Konzerthaus Freiburg . The authors will be in attendance during coffee and lunch breaks on both days .

Call for PostersPlease submit your poster abstract before June 30, 2015 . Only one-page abstracts not exceeding 300 words, written in English and saved in Microsoft Word format will be accepted .

Abstracts must be submitted via our Internet Abstract Submission System (http://www .falkfoundation .org/poster) where further information regarding the submission format and the submission process will be available .

The abstracts will be selected by the scientific organizers, preference being given to those thematically related to one of the sessions of the program .

The accepted abstracts will be printed and distributed to the participants of the congress together with the documents of the meeting .

The authors will receive notification about acceptance and further instructions in July 2015 .

Contact address for further information on the poster session:

Falk Foundation e . V . Congress Department Leinenweberstr . 5 79108 Freiburg (Germany) Telephone: +49 (0)761/1514-0 Telefax: +49 (0)761/1514-359 Web address for submitting poster abstracts: http://www .falkfoundation .org/poster

For the first author of an accepted poster, expenses for accommodation (October 13 16, 2015) and fees for the scientific program and evening activities will be covered during the Falk Symposium 199 . Travel expenses will not be covered .

Poster PrizesThree prizes will be awarded for the best presentations . Prize winners will be presented with a certificate and prize money for e 1,500, e 1,000 and e 500, respectively . Travel expenses will be covered additionally for the first author of prize winning posters .

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List of Speakers, Moderators and Scientific Organizers

Ramon Bataller, M.D., Ph.D.UNC School of MedicineDept . of Gastroenterology and Hepatology101 Manning DriveChapel Hill, NC 27514 USAramon_bataller@med .unc .edu

Prof. Dr. Dr. h.c. mult. Hubert E. BlumInnere Medizin IIUniversittsklinikum FreiburgHugstetter Str . 5579106 FreiburgGermanyhubert .blum@uniklinik-freiburg .de

Prof. Dr. Ali E. CanbayGastroenterologie/HepatologieUniversittsklinikum EssenHufelandstr . 5545147 EssenGermanyali .canbay@uk-essen .de

Prof. Dr. Olivier ChazouillresService dhpatologieCHU Paris Est - Hpital Saint-Antoine184 rue du Faubourg Saint-Antoine75012 ParisFranceoliver .chazouilleres@sat .aphp .fr

Dr. Harry R. Dalton Royal Cornwall Hospital Trust European Centre for Environment and Human HealthUniversity of ExeterCornwellTuro TR1 3LJGreat Britain harry .dalton@rcht .cornwall .nhs .uk

Dr. Xavier FornsHospital Clinic of BarcelonaLiver UnitCarrer de Villarroel 17008036 BarcelonaSpainxforns@clinic .ub .es

Prof. Dr. Peter R. GalleInnere Medizin IUniversittsmedizin derJohannes Gutenberg-UniversittLangenbeckstr . 155131 MainzGermanypeter .galle@unimedizin-mainz .de

Guadalupe Garcia-Tsao, M.D.Professor of MedicineYale University333 Cedar Street - 1080 LMPNew Haven, CT 06520USAguadalupe .garcia-tsao@yale .edu

Prof. Dr. Andreas GeierMed . Klinik und Poliklinik IIKlinikum derUniversitt WrzburgOberdrrbacher Str . 697080 WrzburgGermanygeier_a2@medizin .uni-wuerzburg .de

Prof. Dr. Alexander L. GerbesMedizinische Klinik IIKlinikum der UniversittMnchen - GrohadernMarchioninistr . 1581377 MnchenGermanygerbes@med .uni-muenchen .de

Gregory J. Gores, M.D.Professor of MedicineMayo ClinicDivision of Gastroenterology& Hepatology200 First Street SWRochester MN 55905USAgores .gregory@mayo .edu

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Dr. Gideon HirschfieldUniversity of BirminghamCenter of Liver ResearchInstitute of Biomedical ResearchP .O . Box 363Birmingham B15 2TTGreat Britaing .hirschfield@bham .ac .uk

Prof. Dr. Frank LammertKlinik fr Innere Medizin IIUniversittsklinikumdes SaarlandesKirrberger Str . 10066424 HomburgGermanyfrank .lammert@uks .eu

Dr. Riccardo LencioniUniversit di PisaDivision of RadiologyDepartment of OncologyVia Roma, 6756100 PisaItalyriccardo .lencioni@med .unipi .it

Prof. Dr. Ansgar W. LohseMedizinische Klinik IUniversittsklinikum EppendorfMartinistr . 5220251 HamburgGermanyalohse@uke .de

Prof. Dr. Josep M. LlovetHospital Clinico y ProvincialUniversidad de BarcelonaDivision of Liver Diseasesc/ Villarroel no . 17008036 BarcelonaSpainjmllovet@clinic .ub .es

Prof. Dr. Pietro E. MajnoHepatobiliary CenterDiv . of Visceral Surgeryand TransplantationGeneva University Hospitals1211 GenevaSwitzerlandpietro .majno@hcuge .ch

Prof. Dr. Darius MoradpourCentre Hospitalier Universitaire VaudoisDiv . of Gastroenterology& Hepatology BB07-2400Rue du Bougnon 441011 LausanneSwitzerlanddarius .moradpour@chuv .ch

PD Dr. Christoph Neumann-HaefelinInnere Medizin IIUniversittsklinikum FreiburgHugstetter Str . 5579106 FreiburgGermanychristoph .neumann-haefelin@ uniklinik-freiburg .de

Prof. Dr. Gabriel PerlemuterHpital Antoine-Bclre157 rue de la Porte de Trivaux92140 ClamartFrancegabriel .perlemuter@abc .aphp .fr

Prof. Dr. Massimo PinzaniUCL Insitute for Liver andDigestive HealthRoayl Free Hospital U3Pond StreetLondon NW3 2QGGreat Britainm .pinzani@ucl .ac .uk

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Prof. Dr. Mario RizzettoAzienda OspedalieraS . Giovanni Battista di TorinoDivisione di GastroenterologiaCorso Bramante 88/9010126 TorinoItalymrizzetto@cittadellasalute .to .it

Prof. Dr. Martin RssleGastroenterologePraxiszentrum fr Gastroenterologie und EndokrinologieBertoldstr . 4879098 FreiburgGermanymartin-roessle@t-online .de

Prof. Dr. Christian P. StrassburgMedizinische Klinik IUniversittsklinikum BonnSigmund-Freud-Str . 2553127 BonnGermanychristian .strassburg@ukb .uni-bonn .de

Prof. Dr. Dr. Frank TackeMedizinische Klinik IIIUniversittsklinikum AachenPauwelsstr . 3052074 AachenGermanyftacke@ukaachen .de

Prof. Dr. Robert ThimmeInnere Medizin IIUniversittsklinikum FreiburgHugstetter Str . 5579106 FreiburgGermanyrobert .thimme@uniklinik-freiburg .de

Dr. Heinz ZollerUniversittsklinik InnsbruckGastroenterologie/HepatologieAnichstr . 356020 InnsbruckAustriaheinz .zoller@i-med .ac .at

Prof. Dr. Fabien ZoulimLyon UniversityHepatology DepartmentINSERM U1052151 Cours Albert Thomas69003 LyonFrancefabien .zoulim@inserm .fr

Prof. Dr. Jessica Zucman-RossiUniversit Paris DescartesHopital Europen Georges PompidouDepartment of OncologyINSERM U674/116227 rue Juliette Dodu75010 ParisFrancejessica .zucman-rossi@inserm .fr

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General InformationPrior to the opening of the congress

Falk Foundation e . V . Telephone: +49 (0)761/1514-0Congress Department Telefax: +49 (0)761/1514-359Leinenweberstr . 5 E-Mail: symposia@falkfoundation .de79108 Freiburg (Germany)

Congress OfficeDuring Falk Symposium 199

Konzerthaus Freiburg Telephone: +49 (0)175/7795327Konrad-Adenauer-Platz 179098 FreiburgGermany

Opening Hours:Tuesday, October 13, 2015 16 .00 21 .00 hWednesday, October 14, 2015 8 .00 18 .00 hThursday, October 15, 2015 8 .30 15 .00 h

Congress FeesScientific program of the Falk Symposium 199 e 200 .00Students and residents e 100 .00

* * * OR * * *

Day ticket e 120 .00Students and residents e 60 .00

Employees of pharmaceutical or other companies and their guestsFalk Symposium 199 e 600 .00

The congress fees include:- Welcome Evening on October 13, 2015- Refreshments during coffee breaks- Lunch on October 14-15, 2015- A copy of the abstract volume- Underground parking at the Konzerthaus Freiburg

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RegistrationCongress registrations must reach the Falk Foundation e . V . by July 31, 2015 at the latest . After receipt of the registration form, each participant will be provided with an invoice/confirmation . On presentation of this confirmation at the congress office in Freiburg participants will receive the congress folder containing name badges, admission tickets and abstract volume .In the event of registration cancellations, a handling fee of e 20 .00 will be deducted from the refund . All participants will receive a written confirmation of attendance at the end of the meeting .

Admission to Scientific EventsFor admission to scientific events your name badge should be clearly visible .

Congress ReportThe official congress report of the Falk Symposium 199 Highlights from Hepatology 2015: From Chronic Hepatitis to Hepatocellular Carcinoma will be published in English in the first half of 2016 by Karger, Switzerland . Orders for this book at a reduced subscription price of e 35 .00 can be placed at the Congress Office during the congress in Freiburg .

Congress Short ReportThe congress short report of the Falk Symposium 199-200 will be published by the Falk Foundation e .V . with number FSR 199-200 in the first half of 2016 .

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AirportsEuroAirport Basel-Mulhouse-Freiburg http://www .euroairport .com/en/

Frankfurt International Airport www .frankfurt-airport .com

Airport Transfer http://www .freiburger-airportservice .de/en/

Train Connections http://www .bahn .com

Directions to Konzerthaus FreiburgFrom the North or the South, take A5 autobahn/motorway Frankfurt-Basel along the Rhine Valley, exit Freiburg Mitte . Stay on the autobahn feeder road Mitte until exit Konzerthaus Freiburg (10 min .), follow signs to the Konzerthaus Freiburg .

A81 Stuttgart-Singen autobahn/motorway or B31 (Hllental), Donaueschingen, Titisee-Neustadt . Go through Freiburg on the Schwarzwaldstrasse, this becomes Schreiberstrasse, direction of the autobahn feeder road Mitte . There are road signs to the Konzerthaus Freiburg .

Connections to the French and Swiss autobahn/motorway networks . 950 parking places in the underground car park at the Konzerthaus and central train station (Hauptbahnhof) .

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Directions to the Konzerthaus Freiburg

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General Information:

FALK FOUNDATION e.V.Leinenweberstr. 579108 FreiburgGermany

Congress DepartmentTelephone: +49(0)761/1514-0Telefax: +49(0)761/1514-359E-Mail: symposia@falkfoundation.dewww.falkfoundation.org

VP1

99e

1-11

/201

4/2

.50

0 St

Preliminary Program

Falk Symposium 199

Highlights from Hepatology 2015: From Chronic Hepatitis to Hepatocellular Carcinoma

October 14 15, 2015Konzerthaus FreiburgFreiburg, Germany

Application for CME credits submitted

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