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From Feasibility to Industrial Production · to multi-ton production of chemicals. Corning®...

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Corning Incorporated is the world leader in specialty glass and ceramics. Corning’s Advanced-Flow™ reactors are specially designed for the seamless transition from lab feasibility to process development to industrial-scale to multi-ton production of chemicals. Corning® Advanced- Flow™ reactors are designed to meet the needs of pharmaceutical, fine, and specialty chemical companies who are seeking process optimization of a particular reaction or a wide portfolio of reactions. These reactors comprise highly engineered fluidic modules that integrate heat-transfer and mass-transfer in a single piece of equipment. These easily scalable reactors enable seamless, cost effective solutions for fast scale-up and time to market. Corning® Advanced-Flow™ reactors increase the efficiency, scalability, yields, and quality of chemical processing while reducing environmental impact, performance variability, and cost. Regional Contacts EMEA AND NSA Corning S.A.S Reactor Technologies 7 bis Avenue de Valvins CS 70156 Samois sur Seine 77215 Avon Cedex, France t + 33 1 64 69 71 07 f + 33 1 64 69 70 59 [email protected] CHINA Corning China (Shanghai) RHQ No. 358 Lu Qiao Road, Jinqiao Export Processing Zone, Pudong Shanghai 201206, China t + 86 21 22152888 *1408 f + 86 21 62152988 [email protected] INDIA Corning Technologies India Pvt. Ltd. 2nd Floor, DLF Building 9B DLF Cyber City Phase III Gurgaon, Haryana 122002, India t + 91 124 4604000 f + 91 124 4604099 [email protected] www.corning.com/reactors © 2015 Corning Incorporated. All Rights Reserved May 2015 From Feasibility to Industrial Production Corning® Advanced-Flow™ Reactors Higher yields, lower costs Corning innovation brings significant performance benefits to the chemical processing industry through Corning® Advanced-Flow™ reactors — a full range of reactor products suited to meet the needs of a particular reaction or a wide portfolio of reactions. Continuous-flow chemical production utilizing Corning® Advanced-Flow™ reactors can provide: Corning® Advanced-Flow™ reactors can be effectively run on reactions with miscible and immiscible liquids, and gases and liquids containing some amounts of small solid particles, with dimensions up to 200 microns. Many different types of reactions are well suited for Corning’s reactor equipment, including: Corning® Advanced-Flow™ reactors can be integrated into existing chemical processing infrastructures and designed upon request to ATEX and GMP standards.Corning’s reactors can be easily incorporated into industrial systems via standard connectors, helping customers migrate to Corning’s technology with little or no downtime. Seamless scale-up Increased production yields Lower overall production costs Enhanced plant safety Higher product quality Decreased waste generation and energy consumption Faster product time to market Nitrations Oxidations Brominations Chlorinations Grignards Alkylations Organo-metallics Hydrogenations Polymerizations, ... and others Customers Include ABA Chemicals Corporation Acoris Albany Molecular Research Inc. (AMRI) Applied Physics Laboratory (APL) Arch Pharmalabs Ltd. Arkema Inc. Ash Stevens Inc. BASF SE Beijing Risun Chemical Technologies Institute Co., Ltd Center for Process Analysis and Control (CPAC) Changzhou University Cosmos CPI Ltd. DAELIM Chemical Co., Ltd. Dalian Huiyuan Fine Chemicals Co., Ltd Dongyue Biochem Co.,Ltd Dow Corning DSM Fine Chemicals Austria Nfg GmbH & Co. KG Finchimica S.p.A. Georgia Tech Ghent University Henan Academy of Sciences Jaas Jiangsu Lee & Man Chemical Ltd. Jiangsu ZW Pharmac eutical Co., Ltd. Jiangxi Normal University Jiangsu Yoke Technology Co.,Ltd Jubilant Life Sciences Ltd. Juhua Group Corp. La Maison Européenne des Procédés Innovants (MEPI) Laviana Lianhe Technology Marktech Massachusetts Institute of Technology (MIT) Medichem S.A. Nanjing University of Technology Nanjing University Huaian High-Tech Institution Nanjing Yuande Pharmaceutical Chemical Co., Ltd. National Institute of Advanced Industrial Science and Technology (AIST) Pcas Peking University Shenzhen Graduate School Porton Research Institute of Nanjing Chemical Industry Group (SINOPEC) Sanofi ScinoPharm Taiwan Ltd. Shandong Brother Tech Shandong Luba Chemical Co., Ltd. Shandong Moris Technology Co.,Ltd Siegfried Ltd. Technology Research Institute of Shanghai Huayi Group The McQuade Group Florida State University The Ryu Group University of Saskatchewan Zhejiang Guobang Pharmaceutical Co., Ltd. Zhejiang Yongtai Technology Co.,Ltd ...and others
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Page 1: From Feasibility to Industrial Production · to multi-ton production of chemicals. Corning® Advanced-Flow™ reactors are designed to meet the needs of pharmaceutical, fine, and

Corning Incorporated is the world leader in specialty glass and ceramics. Corning’s Advanced-Flow™ reactors are specially designed for the seamless transition from labfeasibility to process development to industrial-scaleto multi-ton production of chemicals. Corning® Advanced-Flow™ reactors are designed to meet the needs of pharmaceutical, fine, and specialty chemical companies who are seeking process optimization of a particular reaction or a wide portfolio of reactions. These reactors comprise highly engineered fluidic modules that integrate heat-transfer and mass-transfer in a single piece of equipment. These easily scalable reactors enable seamless, cost effective solutions for fast scale-up and time to market. Corning® Advanced-Flow™ reactors increase the efficiency,scalability, yields, and quality of chemical processing whilereducing environmental impact, performance variability,and cost.

Regional ContactsEMEA AND NSA

Corning S.A.SReactor Technologies7 bis Avenue de ValvinsCS 70156 Samois sur Seine77215 Avon Cedex, Francet + 33 1 64 69 71 07f + 33 1 64 69 70 [email protected]

CHINA

Corning China (Shanghai) RHQNo. 358 Lu Qiao Road, Jinqiao ExportProcessing Zone, PudongShanghai 201206, Chinat + 86 21 22152888 *1408f + 86 21 [email protected]

INDIA

Corning Technologies India Pvt. Ltd.2nd Floor, DLF Building 9BDLF Cyber City Phase IIIGurgaon, Haryana 122002, Indiat + 91 124 4604000f + 91 124 [email protected]

www.corning.com/reactors

© 2015 Corning Incorporated. All Rights Reserved May 2015

From Feasibilityto Industrial ProductionCorning® Advanced-Flow™ Reactors

Higher yields, lower costsCorning innovation brings significant performancebenefits to the chemical processing industry throughCorning® Advanced-Flow™ reactors — a full range of reactorproducts suited to meet the needs of a particular reaction ora wide portfolio of reactions.

Continuous-flow chemical production utilizing Corning®Advanced-Flow™ reactors can provide:

Corning® Advanced-Flow™ reactors can be effectively run onreactions with miscible and immiscible liquids, and gasesand liquids containing some amounts of small solid particles,with dimensions up to 200 microns.

Many different types of reactions are well suited for Corning’sreactor equipment, including:

Corning® Advanced-Flow™ reactors can be integrated intoexisting chemical processing infrastructures and designedupon request to ATEX and GMP standards.Corning’s reactorscan be easily incorporated into industrial systems via standardconnectors, helping customers migrate to Corning’stechnology with little or no downtime.

Seamless scale-upIncreased production yieldsLower overall production costsEnhanced plant safetyHigher product qualityDecreased waste generation and energy consumptionFaster product time to market

NitrationsOxidationsBrominationsChlorinationsGrignardsAlkylationsOrgano-metallicsHydrogenationsPolymerizations,... and others

Customers IncludeABA Chemicals CorporationAcorisAlbany Molecular Research Inc. (AMRI)Applied Physics Laboratory (APL)Arch Pharmalabs Ltd.Arkema Inc.Ash Stevens Inc.BASF SEBeijing Risun Chemical Technologies Institute Co., LtdCenter for Process Analysis and Control (CPAC)Changzhou UniversityCosmosCPI Ltd.DAELIM Chemical Co., Ltd.Dalian Huiyuan Fine Chemicals Co., LtdDongyue Biochem Co.,LtdDow CorningDSM Fine Chemicals Austria Nfg GmbH & Co. KGFinchimica S.p.A.Georgia TechGhent UniversityHenan Academy of SciencesJaasJiangsu Lee & Man Chemical Ltd.Jiangsu ZW Pharmac eutical Co., Ltd.Jiangxi Normal UniversityJiangsu Yoke Technology Co.,LtdJubilant Life Sciences Ltd.Juhua Group Corp.La Maison Européenne des Procédés Innovants (MEPI)LavianaLianhe TechnologyMarktechMassachusetts Institute of Technology (MIT)Medichem S.A.Nanjing University of TechnologyNanjing University Huaian High-Tech InstitutionNanjing Yuande Pharmaceutical Chemical Co., Ltd.National Institute of Advanced Industrial Science andTechnology (AIST)PcasPeking University Shenzhen Graduate SchoolPortonResearch Institute of Nanjing Chemical Industry Group(SINOPEC)SanofiScinoPharm Taiwan Ltd.Shandong Brother TechShandong Luba Chemical Co., Ltd.Shandong Moris Technology Co.,LtdSiegfried Ltd.Technology Research Institute of Shanghai Huayi GroupThe McQuade Group Florida State UniversityThe Ryu GroupUniversity of SaskatchewanZhejiang Guobang Pharmaceutical Co., Ltd.Zhejiang Yongtai Technology Co.,Ltd...and others

Page 2: From Feasibility to Industrial Production · to multi-ton production of chemicals. Corning® Advanced-Flow™ reactors are designed to meet the needs of pharmaceutical, fine, and

Corning® Advanced-Flow™ Reactor — Seamless Scale-Up from Laboratory to ProductionHigh flexibility — Metal-free reaction path

Low internal volumeRun continuous chemical processesat laboratoryUse minimal quantities of reactantsto run test

Small internal volumeScalable from test to productionProcess development and optimizationtoolEvaluate technical and commercialbenefits of continuously runningchemistry

Large internal volumeContinuous production of largeamounts of chemicals—severaltons/yearRealize potential of full scale economy

Large internal volumeReduced footprintProcessing capability >300 kg/hrSuperior corrosion resistance

Low-Flow Reactor G1 Standard Evaluation Reactor G3 Glass Reactor G4 Ceramic Reactor

Flow rates: (ml/min)

Single plate volume: (ml)

2 to 10

0.45

30 to 200

8 to 11

400 to 2000

55 to 65

1000 to 5000

200 to 260

Boundary Conditions Corning’s Broad Portfolio of Advanced-Flow™ Reactors — G1, G3, and G4

Design Conditions

Temperature (°C)

Pressure ( barg )

Process Path

-60 to 200

0 to 18

Heat Exchange Path

-60 to 200

0 to 6

G1

G3

G4Ceramic

kg/ h

25 50 75 100

125

150

175

200

225

250

275

300


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