Corning Incorporated is the world leader in specialty glass and ceramics. Corning’s Advanced-Flow™ reactors are specially designed for the seamless transition from labfeasibility to process development to industrial-scaleto multi-ton production of chemicals. Corning® Advanced-Flow™ reactors are designed to meet the needs of pharmaceutical, fine, and specialty chemical companies who are seeking process optimization of a particular reaction or a wide portfolio of reactions. These reactors comprise highly engineered fluidic modules that integrate heat-transfer and mass-transfer in a single piece of equipment. These easily scalable reactors enable seamless, cost effective solutions for fast scale-up and time to market. Corning® Advanced-Flow™ reactors increase the efficiency,scalability, yields, and quality of chemical processing whilereducing environmental impact, performance variability,and cost.
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CHINA
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INDIA
Corning Technologies India Pvt. Ltd.2nd Floor, DLF Building 9BDLF Cyber City Phase IIIGurgaon, Haryana 122002, Indiat + 91 124 4604000f + 91 124 [email protected]
www.corning.com/reactors
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From Feasibilityto Industrial ProductionCorning® Advanced-Flow™ Reactors
Higher yields, lower costsCorning innovation brings significant performancebenefits to the chemical processing industry throughCorning® Advanced-Flow™ reactors — a full range of reactorproducts suited to meet the needs of a particular reaction ora wide portfolio of reactions.
Continuous-flow chemical production utilizing Corning®Advanced-Flow™ reactors can provide:
Corning® Advanced-Flow™ reactors can be effectively run onreactions with miscible and immiscible liquids, and gasesand liquids containing some amounts of small solid particles,with dimensions up to 200 microns.
Many different types of reactions are well suited for Corning’sreactor equipment, including:
Corning® Advanced-Flow™ reactors can be integrated intoexisting chemical processing infrastructures and designedupon request to ATEX and GMP standards.Corning’s reactorscan be easily incorporated into industrial systems via standardconnectors, helping customers migrate to Corning’stechnology with little or no downtime.
Seamless scale-upIncreased production yieldsLower overall production costsEnhanced plant safetyHigher product qualityDecreased waste generation and energy consumptionFaster product time to market
NitrationsOxidationsBrominationsChlorinationsGrignardsAlkylationsOrgano-metallicsHydrogenationsPolymerizations,... and others
Customers IncludeABA Chemicals CorporationAcorisAlbany Molecular Research Inc. (AMRI)Applied Physics Laboratory (APL)Arch Pharmalabs Ltd.Arkema Inc.Ash Stevens Inc.BASF SEBeijing Risun Chemical Technologies Institute Co., LtdCenter for Process Analysis and Control (CPAC)Changzhou UniversityCosmosCPI Ltd.DAELIM Chemical Co., Ltd.Dalian Huiyuan Fine Chemicals Co., LtdDongyue Biochem Co.,LtdDow CorningDSM Fine Chemicals Austria Nfg GmbH & Co. KGFinchimica S.p.A.Georgia TechGhent UniversityHenan Academy of SciencesJaasJiangsu Lee & Man Chemical Ltd.Jiangsu ZW Pharmac eutical Co., Ltd.Jiangxi Normal UniversityJiangsu Yoke Technology Co.,LtdJubilant Life Sciences Ltd.Juhua Group Corp.La Maison Européenne des Procédés Innovants (MEPI)LavianaLianhe TechnologyMarktechMassachusetts Institute of Technology (MIT)Medichem S.A.Nanjing University of TechnologyNanjing University Huaian High-Tech InstitutionNanjing Yuande Pharmaceutical Chemical Co., Ltd.National Institute of Advanced Industrial Science andTechnology (AIST)PcasPeking University Shenzhen Graduate SchoolPortonResearch Institute of Nanjing Chemical Industry Group(SINOPEC)SanofiScinoPharm Taiwan Ltd.Shandong Brother TechShandong Luba Chemical Co., Ltd.Shandong Moris Technology Co.,LtdSiegfried Ltd.Technology Research Institute of Shanghai Huayi GroupThe McQuade Group Florida State UniversityThe Ryu GroupUniversity of SaskatchewanZhejiang Guobang Pharmaceutical Co., Ltd.Zhejiang Yongtai Technology Co.,Ltd...and others
Corning® Advanced-Flow™ Reactor — Seamless Scale-Up from Laboratory to ProductionHigh flexibility — Metal-free reaction path
Low internal volumeRun continuous chemical processesat laboratoryUse minimal quantities of reactantsto run test
Small internal volumeScalable from test to productionProcess development and optimizationtoolEvaluate technical and commercialbenefits of continuously runningchemistry
Large internal volumeContinuous production of largeamounts of chemicals—severaltons/yearRealize potential of full scale economy
Large internal volumeReduced footprintProcessing capability >300 kg/hrSuperior corrosion resistance
Low-Flow Reactor G1 Standard Evaluation Reactor G3 Glass Reactor G4 Ceramic Reactor
Flow rates: (ml/min)
Single plate volume: (ml)
2 to 10
0.45
30 to 200
8 to 11
400 to 2000
55 to 65
1000 to 5000
200 to 260
Boundary Conditions Corning’s Broad Portfolio of Advanced-Flow™ Reactors — G1, G3, and G4
Design Conditions
Temperature (°C)
Pressure ( barg )
Process Path
-60 to 200
0 to 18
Heat Exchange Path
-60 to 200
0 to 6
G1
G3
G4Ceramic
kg/ h
25 50 75 100
125
150
175
200
225
250
275
300