From Lecture Hall to From Lecture Hall to Production FloorProduction Floor

Academia IndustryAcademia Industry

Ramot at Tel Aviv University Ltd.

Presented by Larry Loev

Academia – Common Myths

• Research is not applicable to the real world

• University personnel don’t understand industry time frames

• Industrial standards can’t be maintained

• The urge to publish damages confidentiality

Why Academia?

• Top researchers

• Peer reviewed technology

• Lab facilities

• “Cross-fertilization”

• Technologies with wide applications

• IP vigorously protected

Challenge: Contrasting Cultures

University

Social responsibilities

Pure scientific driven research

Create new knowledge

Corporate

Shareholders responsibilities

Specific objectives, product focused

Develop new products

Applied research

Ownership & secrecy

Control of material

Basic research Publications & collaborations

Sharing of material

The Facilitator

The University Tech Transfer Office

Case Study: Ramot at TAU

• Ramot Objectives

To foster, initiate and lead the transfer of To foster, initiate and lead the transfer of new technologies from the laboratory to new technologies from the laboratory to the marketplacethe marketplace

To strengthen the relationship between To strengthen the relationship between University research community and the University research community and the business community business community

Ramot - Board of Directors

• Industry, Venture Capital, Law– Mr. Dov Lautman, Chairman of

Delta Galil Industries– Dr. David Haselkorn, former

president of Clal Biotechnologies

– Mr. Moshe (Mori) Arkin, Vice Chairman of Perrigo

– Mr. Hemi Peres, GP, Pitango Venture Capital

– Mr. Shmaryahu Shapiro, CEO, Technorov holdings

– Ms. Tally Eitan, Adv., Eitan Law Group

• University leadership & scientists– Professor Hagit Messer-Yaron,

Ramot Chairperson,VP Research & Development

– Professor Zvi Galil, President– Mr. Mordehai Kohn, Director

General– Professor Dany Leviatan, Rector– Professor Yair Aharonovitz,– Professor Yoel Kloog, Dean,

Faculty of Life Sciences

Tech Transfer Process

Revenues

Discovery &Innovation

EvaluationPatenting & Marketing Strategy

Business Development

Follow Upon Contract

Academic Basic and Applied Research

Ramot OrganizationRamot Organization

Business DevelopmentEngineering, Computer Science, Exact SciencesLife sciencesMedical devices

IP managementLegal

Bridging the Development Gap

• A Development Gap lies between discovery and commercialization

• Required: applied research, first prototype stage– Looks like a product, performs certain specs

• Solution: feasibility research– Sponsored by target licensee– Sponsored by special funds (Ramot Fund,

Partnership, etc.)

Deal ModelsDeal Models

Research Funds

Fees and Milestones

payments

Running Royalties

Equity participation

Research and Research and Development AgreementsDevelopment Agreements

Funded by companies, Israeli government

Licensing DealsLicensing Deals

Licensing of IP, know how to an existing company

New venture formation / New venture formation / Spin-offsSpin-offs

Licensing of IP to the start-up company

“Lines in the Sand”

• IP - the heart and soul of a University’s property

• Product Diligence – Responsibility to the public

Tel Aviv UniversityTel Aviv University

• Established 1956 • 9 faculties, 24 schools, 105

departments • over 100 research institutes • 30,000 students, 1,800 of

them are doctorate students • 2,200 faculty members

About Tel Aviv University

Research Highlights

Life sciences (120 researchers(Medicine (130 researchers(Exact sciences (240 researchers(Engineering (110 researchers)

600 researchers are affiliated with the main medical centers in greater Tel Aviv area

Thank You

Larry LoevManager Business Development,

Engineering and Physical Sciences

Larry.loev@ramot.org

www.ramot.org

Extra Slides

Development GapDevelopment Gap

fundingfunding Potential licensee point of viewPotential licensee point of view (answer the right questions…)(answer the right questions…)

Funding of Research by target licenseeFunding of Research by target licensee under an R&L/R&O agreementunder an R&L/R&O agreement

Funding of Research by special funds: Funding of Research by special funds: Stringent screening process based on bothStringent screening process based on bothcommercial and scientific criteria. commercial and scientific criteria. Plan, Budget & Milestones Plan, Budget & Milestones Stringent monitoring of the process.Stringent monitoring of the process.

Industry Requirements

A prototype, Looks like a product, performs certain specs

Pre-clinical results , efficacy in animal models, Toxicology

* Funded by the Yeshaya Horowitz Association , Jerusalem

Philanthropic funds Tel Aviv University Fund for Applied Research*

The Colton Family Next Generation Technologies Institute

“TAU Fund for Applied Research” supports 7-10 projects per year, $3M in 2003-6

Projects are selected following a stringent process by Ramot and a professional committee, to meet commercial as well as scientific criteria

“The Colton Fund” - Matching funds by Johnson & Johnson

Bridging the Gap (I)Bridging the Gap (I)

A corporate partner allocates an annual amount to support of research in pre-defined areas of interest.The fund solicits highly promising projects with IP position,

development plan and clearly defined commercialization pathA joint steering committee of the corporate partner, TAU and Ramot evaluated and selects projectsRamot provides strategic and scientific guidance with a clear market focusThe corporate partner has certain rights in the IP generated in the researchTwo such multi-million dollar funds are currently operational: nano-technology and smart-cards

Bridging the Gap (II)Bridging the Gap (II)

Bridging the Gap (III)Bridging the Gap (III)

TAU-TechTAU-Tech

TAU Future Technology Partnership (TAU-Tech)

Return on investment

Tel Aviv University

technologies

Industry

Licensing: royalties and fees

Start-ups:Equity participation

Ramot:

Technology management

Business development

Technology transfer

investment

$8.5M

TAU-Tech ProjectsTAU-Tech Projects

Biotechnology Drug candidates for Alzheimer’s Disease Drug candidates for type II diabetes Novel cancer targeted drug delivery system

Medical Devices Direct lung fluid monitoring system for

congestive heart failure patients in Clinical Trials Optical Micro-Biosensors for Biomedical Diagnosis

Energy & Electronics Fuel cells for mobile electronics and industrial applications Micro-battery on a chip

IP Protection & Commercialization Strategy: LicenseLicense

Mouthwash

R&L (Israel)

Product

R&L (UK)

Product20% UK market share

Alzheimer’s

TAU Fund

Proof of concept

TAU Tech•Lead compound•Pre-clinical package

R&L

Schizophrenia

R&L (BioLineRx)

Drug Candidate

Phase II – Q4 ‘07

Commercialization Commercialization pathspaths

Pipeline – Bio/Pharma

Company Disease/Condition Researcher Pre-Clinical

Clinical Phase I

Clinical Phase II

Clinical Phase III

Market

Tubilux Pharma Ocular Disorders Prof. Savion, Dr. Solomon

Allon Therapeutics MCI/stroke Prof. Illana Gozes

Allon Therapeutics Alzheimer’s disease Prof. Illana Gozes

Allon Therapeutics Schizophrenia Prof. Illana Gozes

Epix Pharmaceuticals Depression Dr. Oren Becker, Prof. Zvi Naor

Epix Pharmaceuticals Pulmonary Hypertension Dr. Oren Becker, Prof. Zvi Naor

Epix Pharmaceuticals Alzheimer’s disease Dr. Oren Becker, Prof. Zvi Naor

Wyeth / Elan Alzheimer's disease Prof. Beka Solomon

BioLineRx Schizophrenia Prof. Weizmann, Dr. Rephaeli, Dr. Gilad

Biotech Company Cancer Prof. Yoel Kloog

Epix Pharmaceuticals Obesity, AD & Schizoph. Dr. Oren Becker, Prof. Zvi Naor

Allergica Anti Allergic drug Prof. Ronit Sagi-Eisenberg

Sepal Pharma Cancer Dr. Eliezer Flescher

BrainStorm Cell Th. Parkinson' disease Prof. Eldad Melamed, Dr Daniel Offen

Merz Pharmaceuticals Alzheimer's disease Prof. Ehud Gazit

LovaDerm Acne Prof. Naftali Savion, Prof. Sara Brener

Biotech Company Pain/Epilepsy Prof. Bernard Attali, Prof. Amiram Raz

Diagnostic, medical devices and agro pipelineDiagnostic, medical devices and agro pipeline

Company Product/Field Researcher PreClin./ Prototype

Clinical Phase

Market

FreshBreath Mouth wash Prof. Mel Rosenberg

Matis Medical Platelet function Prof. Naphtali Savion

Novamed Diagnostic kit Prof. Mel Rosenberg

EnzySurge Wound healing Prof. Amihay Freeman

The Center for Potato Research Transgenic potatoes Prof. Zilberstein, Prof. Sneh

Frutarom Anti-virus nutraceutical Prof. Michael Ovadia

Engineering / exact sciences pipelineEngineering / exact sciences pipeline

Company Technology Researcher Development Market

Symbol Increased depth of focus Prof. Emanuel Marom, Prof. David Mendelovic

BioPetroClean Bioremediation oil contaminants Prof. Eugene Rosenberg, Prof. Eliora Ron

Polymicro Optical fibers Prof. Nathan Croitoru

SanDisk Flash memory x4 technology Prof. Simon Litsyn

Pipeline (II)

Current Available Current Available

Bio-Medical TechnologiesBio-Medical Technologies

Pharmaceuticals/Biotechnology• Cardiovascular & Angiogenesis• Alzheimer’s Disease• Amyloid Diseases • Cancer• CNS• Diabetes• Drug Delivery • Onychomycosis• Stem Cell Therapy• Virology

Diagnostics• Liver Diseases

Medical Devices• Lung fluid monitoring• Drug delivery• Continuous non-invasive blood

pressure monitoring• Magnetic resonance imaging of

macromolecules and connective tissue

• Advanced Echocardiography

TAU and Ramot LinksTAU and Ramot Links

TAU Research Catalog: www.tau.ac.il

Research

Research Catalog

Ramot Available Technologies: www.ramot.org

Available Technologies