Front Matter

Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 94, No. 21 (Oct. 14, 1997), pp. i-xivPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/43237 .

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PROCEEDINGS OF THE

NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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OF THE UNITED STATES OF AMERICA

October 14, 1997 Volume 94, Number 21 pp. 11109-11752

7 Table of Contents

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Papers from a National Academy of Sciences Colloquium on Elliptic Curves and Modular Forms

Introduction 11109 Barry Mazur and Karl Rubin

Parametrizations of elliptic curves by Shimura 11110-11114 curves and by classical modular curves

Kenneth A. Ribet and Shuzo Takahashi

Euler characteristics and elliptic curves 11115-11117 John Coates and Susan Howson

The amazing consequences of elliptic curves play a key role in the number theory. Elliptic curves are smooth cubic plane curves with a "flex point" at infinity. As has been known for centuries, there is a natural way of "adding" two points on an elliptic curve to get a third so that the sum of any three collinear points yields the point at infinity. In the diagram above, the graph of an elliptic curve is drawn, along with straight lines illustrating the associativity of the law of addition.

p-adic L functions and trivial zeroes 11118-11120 Bernadette Perrin-Riou

Adjoint modular Galois representations 11121-11124 and their Selmer groups

Haruzo Hida, Jacques Tilouine, and Eric Urban

The structure of Selmer groups 11125-11128 Ralph Greenberg

On the coefficients of the characteristic series of 11129-11132 the U-operator

Robert F. Coleman

Zeta functions and Eisenstein series on 11133-11137 classical groups

Goro Shimura

Deforming semistable Galois representations 11138-11141 Jean-Marc Fontaine

Integrality of Tate-cycles 11142 Gerd Faltings

Congruences between modular forms: Raising 11143-11146 the level and dropping Euler factors

Fred Diamond

On degree 2 Galois representations over D4 11147-11148 Nicholas Shepherd-Barron and Richard Taylor

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Contents

Commentaries

Broccoli sprouts as inducers of 11149-11151 carcinogen-detoxifying enzyme systems: Clinical, dietary, and policy implications

Marion Nestle

Immune responsiveness in vector insects 11152-11153 Jules A. Hoffmann

Wolbachia run amok 11154-11155 John H. Werren

Inaugural Articles

A phylogenetic perspective on P transposable 11428-11433 element evolution in Drosophila

Jonathan B. Clark and Margaret G. Kidwell

Phosphorylation of two regulatory tyrosine 11526-11533 residues in the activation of Bruton's tyrosine kinase via alternative receptors

Matthew I. Wahl, Anne-Catherine Fluckiger, Roberta M. Kato, Hyunsun Park, Owen N. Witte, and David J. Rawlings

Physical Sciences

CHEMISTRY

An artificial cytochrome P450 that hydroxylates 11156-11158 unactivated carbons with regio- and stereoselectivity and useful catalytic turnovers

Ronald Breslow, Ying Huang, Xiaojun Zhang, and Jerry Yang

Comparison of structures and energies of CHs+ 11159-11162 with CH-' and their possible role in superacidic methane activation

Golam Rasul, G. K. Surya Prakash, and George A. Olah

GEOLOGY

High-precision 40Ar/39Ar geochronology and the 11163-11167 advent of North America's Late Cretaceous terrestrial fauna

Richard L. Cifelli, James I. Kirkland, Anne Weil, Alan L. Deino, and Bart J. Kowallis

Biological Sciences

BIOCHEMISTRY

An artificial cytochrome P450 that hydroxylates 11156-11158 unactivated carbons with regio- and stereoselectivity and useful catalytic turnovers

Ronald Breslow, Ying Huang, Xiaojun Zhang, and Jerry Yang

Oxidative damage during aging targets 11168-11172 mitochondrial aconitase

Liang-Jun Yan, Rodney L. Levine, and Rajindar S. Sohal

A yeast sterol auxotroph (erg25) is rescued by addition 11173-11178 of azole antifungals and reduced levels of heme

D. Gachotte, C. A. Pierson, N. D. Lees, R. Barbuch, C. Koegel, and M. Bard

Sphingomyelin depletion in cultured cells blocks 11179-11183 proteolysis of sterol regulatory element binding proteins at site 1

Sigrid Scheek, Michael S. Brown, and Joseph L. Goldstein

D-AKAP2, a novel protein kinase A anchoring 11184-11189 protein with a putative RGS domain

Lily Jun-shen Huang, Kyle Durick, Joshua A. Weiner, Jerold Chun, and Susan S. Taylor

Three Ever Shorter Telomere (EST) genes are 11190-11195 dispensable for in vitro yeast telomerase activity

Joachim Lingner, Thomas R. Cech, Timothy R. Hughes, and Victoria Lundblad

The cysteine-rich frizzled domain of Frzb-1 11196-11200 is required and sufficient for modulation of Wnt signaling

Keming Lin, Shouwen Wang, Martin A. Julius, Jan Kitajewski, Malcolm Moos, Jr., and Frank P. Luyten

Converting a transmembrane receptor to a soluble 11201-11204 receptor: Recognition domain to effector domain signaling after excision of the transmembrane domain

Karen M. Ottemann and Daniel E. Koshland, Jr.

Cockayne syndrome group B protein enhances 11205-11209 elongation by RNA polymerase II

Christopher P. Selby and Aziz Sancar

Inorganic polyphosphate and the induction of 11210-11215 rpoS expression

Toshikazu Shiba, Kaori Tsutsumi, Hiroyuki Yano, Yoshiharu Ihara, Atsushi Kameda, Kan Tanaka, Hideo Takahashi, Masanobu Munekata, Narayana N. Rao, and Arthur Kornberg

CooA, a CO-sensing transcription factor from 11216-11220 Rhodospirillum rubrum, is a CO-binding heme protein

Daniel Shelver, Robert L. Kerby, Yiping He, and Gary P. Roberts

Recombination activities of HsDmcl protein, the 11221-11226 meiotic human homolog of RecA protein

Zhufang Li, Efim I. Golub, Ravindra Gupta, and Charles M. Radding

Src-induced activation of inducible T cell 11227-11232 kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase

Avery August, Ali Sadra, Bo Dupont, and Hidesaburo Hanafusa

Activation of protein kinase C by tyrosine 11233-11237 phosphorylation in response to H202

Hiroaki Konishi, Motonari Tanaka, Yukitoshi Takemura, Hidenori Matsuzaki, Yoshitaka Ono, Ushio Kikkawa, and Yasutomi Nishizuka

vii



Contents

Sequence-specific recognition of a subgenomic 11238-11243 RNA promoter by a viral RNA polymerase

Robert W. Siegel, Scott Adkins, and C. Cheng Kao

DNA polymerase 8 isolated from 11244-11249 Schizosaccharomyces pombe contains five subunits

Shaojun Zuo, Emma Gibbs, Zvi Kelman, Teresa S.-F. Wang, Mike O'Donnell, Stuart A. MacNeill, and Jerard Hurwitz

ApoNifH functions in iron-molybdenum cofactor 11250-11255 synthesis and apodinitrogenase maturation

Priya Rangaraj, Vinod K. Shah, and Paul W. Ludden

The macrophage/endothelial cell mannose receptor 11256-11261 cDNA encodes a protein that binds oligosaccharides terminating with SO4-4-GalNAcf31,4GlcNAcf3 or Man at independent sites

Dorothy Fiete, Mary C. Beranek, and Jacques U. Baenziger

Chrysanthemum chlorotic mottle viroid: Unusual 11262-11267 structural properties of a subgroup of self-cleaving viroids with hammerhead ribozymes

Beatriz Navarro and Ricardo Flores

RB and hbrm cooperate to repress the activation 11268-11273 functions of E2F1

Didier Trouche, Catherine Le Chalony, Christian Muchardt, Moshe Yaniv, and Tony Kouzarides

Positioning of two alpha subunit carboxy-terminal 11274-11278 domains of RNA polymerase at promoters by two transcription factors

Katsuhiko Murakami, Jeffrey T. Owens, Tamara A. Belyaeva, Claude F. Meares, Stephen J. W. Busby, and Akira Ishihama

Binding of RNA template to a complex of HIV-1 11279-11284 reverse transcriptase/primer/template

Bruno Canard, Robert Sarfati, and Charles C. Richardson

Bioactive and nuclease-resistant L-DNA ligand 11285-11290 of vasopressin

Kelly P. Williams, Xiao-Hong Liu, Ton N. M. Schumacher, Herbert Y. Lin, Dennis A. Ausiello, Peter S. Kim, and David P. Bartel

Subtle atomic group discrimination in the RNA 11291-11294 minor groove

Magali Frugier and Paul Schimmel

A histone deacetylase inhibitor potentiates retinoid 11295-11300 receptor action in embryonal carcinoma cells

Saverio Minucci, Valerie Horn, Nisan Bhattacharyya, Valya Russanova, Vasily V. Ogryzko, Lucia Gabriele, Bruce H. Howard, and Keiko Ozato

BIOPHYSICS

A functionally defined model for the M2 proton 11301-11306 channel of influenza A virus suggests a mechanism for its ion selectivity

Lawrence H. Pinto, Gregg R. Dieckmann, Chris S. Gandhi, Carol G. Papworth, Jeffrey Braman, Margaret A. Shaughnessy, James D. Lear, Robert A. Lamb, and William F. DeGrado

The efficiency of propulsion by a rotating flagellum 11307-11311 Edward M. Purcell

Raman spectral evidence for hydration forces 11312-11317 between collagen triple helices

S. Leikin, V. A. Parsegian, W.-H. Yang, and G. E. Walrafen

Efficient exchange of the primary quinone acceptor 11318-11323 QA in isolated reaction centers of Rhodopseudomonas viridis

Jacques Breton

Evolution of the folding ability of proteins through 11324-11328 functional selection

Seiji Saito, Masaki Sasai, and Tetsuya Yomo

Stability and dynamics in a hyperthermophilic 11329-11332 protein with melting temperature close to 200?C

Reuben Hiller, Zhi H. Zhou, Michael W. W. Adams, and S. Walter Englander

CELL BIOLOGY

MRIT, a novel death-effector domain-containing 11333-11338 protein, interacts with caspases and BC1XL and initiates cell death

David K. M. Han, Preet M. Chaudhary, Michael E. Wright, Cynthia Friedman, Barbara J. Trask, Rodney T. Riedel, Dale G. Baskin, Stephen M. Schwartz, and Leroy Hood

The signal recognition particle receptor of 11339-11344 Escherichia coli (FtsY) has a nucleotide exchange factor built into the GTPase domain

Claudio Moser, Olaf Mol, Roger S. Goody, and Irmgard Sinning

Interleukin 3-dependent survival by the Akt 11345-11350 protein kinase

Zhou Songyang, David Baltimore, Lewis C. Cantley, David R. Kaplan, and Thomas F. Franke

A transformation-associated complex involving 11351-11356 tyrosine kinase signal adapter proteins and caldesmon links v-ErbB signaling to actin stress fiber disassembly

Michael J. McManus, Wilma L. Lingle, Jeffrey L. Salisbury, and Nita J. Maihle

Comparison of the ion channel characteristics of 11357-11362 proapoptotic BAX and antiapoptotic BCL-2

Paul H. Schlesinger, Atan Gross, Xiao-Ming Yin, Kazuhito Yamamoto, Mitsuyoshi Saito, Gabriel Waksman, and Stanley J. Korsmeyer

Endoplasmic reticulum quality control of 11363-11368 asialoglycoprotein receptor H2a involves a determinant for retention and not retrieval

Marina Shenkman, Michal Ayalon, and Gerardo Z. Lederkremer

Integration of multiple instructive cues by 11369-11374 neural crest stem cells reveals cell-intrinsic biases in relative growth factor responsiveness

Nirao M. Shah and David J. Anderson

viii



Contents Role of lipid polymorphism in G protein-membrane 11375-11380 interactions: Nonlamellar-prone phospholipids and peripheral protein binding to membranes

Pablo V. Escriba, Andr6s Ozaita, Catalina Ribas, Antonio Miralles, Elfrieda Fodor, Tibor Farkas, and Jesus A. Garcia-Sevilla

Insulin and insulin-like growth factor-I acutely 11381-11386 inhibit surface translocation of growth hormone receptors in osteoblasts: A novel mechanism of growth hormone receptor regulation

Kin-Chuen Leung, Michael J. Waters, Irit Markus, William R. Baumbach, and Ken K. Y. Ho

Identification of a small, very acidic constitutive 11387-11392 nucleolar protein (NO29) as a member of the nucleoplasmin family

Rudolf F. Zirwes, Marion S. Schmidt-Zachmann, and Werner W. Franke

p23, a major COPI-vesicle membrane protein, 11393-11398 constitutively cycles through the early secretory pathway

Walter Nickel, Kai Sohn, Carsten Biinning, and Felix T. Wieland

MIC-1, a novel macrophage inhibitory cytokine, 11514-11519 is a divergent member of the TGF-3 superfamily

Michelle R. Bootcov, Asne R. Bauskin, Stella M. Valenzuela, Anthony G. Moore, Mohinder Bansal, Xiao Yan He, Hong Ping Zhang, Melissa Donnellan, Stephen Mahler, Kimberley Pryor, Bradley J. Walsh, Richard C. Nicholson, W. Douglas Fairlie, Suzanne B. Por, Joan M. Robbins, and Samuel N. Breit.

DEVELOPMENTAL BIOLOGY

Electrical stimulation of neonatal cardiomyocytes 11399-11404 results in the sequential activation of nuclear genes governing mitochondrial proliferation and differentiation

Yang Xia, L. Maximilian Buja, Richard C. Scarpulla, and Jeanie B. McMillin

Proximo-distal specification in the wing disc of 11405-11410 Drosophila by the nubbin gene

Francisco J. Cifuentes and Antonio Garcia-Bellido

EVOLUTION

High-precision 40Ar/39Ar geochronology and the 11163-11167 advent of North America's Late Cretaceous terrestrial fauna

Richard L. Cifelli, James I. Kirkland, Anne Weil, Alan L. Deino, and Bart J. Kowallis

Phylogenetic relationships between the Acantharea 11411-11416 and the Polycystinea: A molecular perspective on Haeckel's Radiolaria

Linda Amaral Zettler, Mitchell L. Sogin, and David A. Caron

Selective maintenance of allozyme differences 11417-11421 among sympatric host races of the apple maggot fly

Jeffrey L. Feder, Joseph B. Roethele, Brian Wlazlo, and Stewart H. Berlocher

Accelerated evolution as a consequence of 11422-11427 transitions to mutualism

Frangois Lutzoni and Mark Pagel

A phylogenetic perspective on P transposable 11428-11433 element evolution in Drosophila

Jonathan B. Clark and Margaret G. Kidwell

The atypical codon usage of the plantpsbA gene 11434-11438 may be the remnant of an ancestral bias

Brian R. Morton and Justine A. Levin

The role of Wolbachia bacteria in reproductive 11439-11444 incompatibilities and hybrid zones of Diabrotica beetles and Gryllus crickets

Rosanna Giordano, Jan J. Jackson, and Hugh M. Robertson

GENETICS

Activating mutations for the Met tyrosine kinase 11445-11450 receptor in human cancer

Michael Jeffers, Laura Schmidt, Noboru Nakaigawa, Craig P. Webb, Gregor Weirich, Takeshi Kishida, Berton Zbar, and George F. Vande Woude

Cleft palate in mice with a targeted mutation in the 11451-11455 -y-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67

Brian G. Condie, Gerard Bain, David I. Gottlieb, and Mario R. Capecchi

Functional association between promoter structure 11456-11460 and transcript alternative splicing

Paula Cramer, C. Gustavo Pesce, Francisco E. Baralle, and Alberto R. Kornblihtt

Fluorescence in situ hybridization analysis of 11461-11465 keratinocyte growth factor gene amplification and dispersion in evolution of great apes and humans

D. B. Zimonjic, M. J. Kelley, J. S. Rubin, S. A. Aaronson, and N. C. Popescu

Genetic definition of a protein-splicing domain: 11466-11471 Functional mini-inteins support structure predictions and a model for intein evolution

Victoria Derbyshire, David W. Wood, Wei Wu, John T. Dansereau, Jacob Z. Dalgaard, and Marlene Belfort

Characterization of the CHD family of proteins 11472-11477 Trevor Woodage, Munira A. Basrai, Andreas D. Baxevanis, Philip Hieter, and Francis S. Collins

IMMUNOLOGY

Lysis of HIV-1-infected cells and inhibition of viral 11478-11483 replication by universal receptor T cells

Otto 0. Yang, Annie-Chen Tran, Spyros A. Kalams, R. Paul Johnson, Margo R. Roberts, and Bruce D. Walker

Protein S is inducible by interleukin 4 in T cells 11484-11489 and inhibits lymphoid cell procoagulant activity

Stephen T. Smiley, Sarah N. Boyer, Mary J. Heeb, John H. Griffin, and Michael J. Grusby

ix



Contents

Down-regulation of interferon y-activated STAT1 11490-11495 by UV light

Yoshinori Aragane, Dagmar Kulms, Thomas A. Luger, and Thomas Schwarz

Generation of CD8+ T cells specific for transporter 11496-11501 associated with antigen processing deficient cells

Elisabeth Z. Wolpert, Max Petersson, Benedict J. Chambers, Johan K. Sandberg, Rolf Kiessling, Hans-Gustaf Ljunggren, and Klas Karre

Midgut-specific immune molecules are produced 11502-11507 by the blood-sucking insect Stomoxys calcitrans

Michael J. Lehane, Dan Wu, and Stella M. Lehane

Molecular immune responses of the mosquito 11508-11513 Anopheles gambiae to bacteria and malaria parasites

George Dimopoulos, Adam Richman, Hans-Michael Muller, and Fotis C. Kafatos

MIC-1, a novel macrophage inhibitory cytokine, 11514-11519 is a divergent member of the TGF-13 superfamily

Michelle R. Bootcov, Asne R. Bauskin, Stella M. Valenzuela, Anthony G. Moore, Mohinder Bansal, Xiao Yan He, Hong Ping Zhang, Melissa Donnellan, Stephen Mahler, Kimberley Pryor, Bradley J. Walsh, Richard C. Nicholson, W. Douglas Fairlie, Suzanne B. Por, Joan M. Robbins, and Samuel N. Breit

Direct evidence to support the role of HLA-G in 11520-11525 protecting the fetus from maternal uterine natural killer cytolysis

Nathalie Rouas-Freiss, Rachel Marchal-Bras Goncalves, Catherine Menier, Jean Dausset, and Edgardo D. Carosella

Phosphorylation of two regulatory tyrosine 11526-11533 residues in the activation of Bruton's tyrosine kinase via alternative receptors

Matthew I. Wahl, Anne-Catherine Fluckiger, Roberta M. Kato, Hyunsun Park, Owen N. Witte, and David J. Rawlings

Functional cleavage of the common cytokine 11534-11539 receptor y chain (,yc) by calpain

Masayuki Noguchi, Apurva Sarin, M. Javad Aman, Hiroshi Nakajima, Elizabeth W. Shores, Pierre A. Henkart, and Warren J. Leonard

MEDICAL SCIENCES

Targeted disruption of the mouse gene encoding 11540-11545 steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia

Kathleen M. Caron, Shiu-Ching Soo, William C. Wetsel, Douglas M. Stocco, Barbara J. Clark, and Keith L. Parker

Identification of the prooxidant site of human 11546-11551 ceruloplasmin: A model for oxidative damage by copper bound to protein surfaces

Chinmay K. Mukhopadhyay, B3arsanjit Mazumder, Peter F. Lindley, and Paul L. Fox

Murine hematopoietic stem cells committed to 11552-11556 macrophage/dendritic cell formation: Stimulation by Flk2-ligand with enhancement by regulators using the gp130 receptor chain

Donald Metcalf

The role of polyamine catabolism in polyamine 11557-11562 analogue-induced programmed cell death

Hyo Chol Ha, Patrick M. Woster, James D. Yager, and Robert A. Casero, Jr.

A factor IX-deficient mouse model for hemophilia B 11563-11566 gene therapy

Lili Wang, Monica Zoppe, Tilman M. Hackeng, John H. Griffin, Kuo-Fen Lee, and Inder M. Verma

Phenotypic knockout of HIV type 1 chemokine 11567-11572 coreceptor CCR-5 by intrakines as potential therapeutic approach for HIV-1 infection

An-Gang Yang, Xuefan Bai, Xue F. Huang, Changping Yao, and Si.-Yi Chen

Governing step of metastasis visualized in vitro 11573-11576 Takashi Chishima, Meng Yang, Yohei Miyagi, Lingna Li, Yuying Tan, Eugene Baranov, Hiroshi Shimada, A. Rahim Moossa, Sheldon Penman, and Robert M. Hoffman

Random locomotion and chemotaxis of human 11577-11582 blood polymorphonuclear leukocytes (PMN) in the presence of EDTA: PMN in close quarters require neither leukocyte integrins nor external divalent cations

Stephen E. Malawista and Anne de Boisfleury Chevance

Panhandle PCR strategy to amplify MLL genomic 11583-11588 breakpoints in treatment-related leukemias

Maureen D. Megonigal, Eric F. Rappaport, Douglas H. Jones, Caroline S. Kim, Peter C. Nowell, Beverly J. Lange, and Carolyn A. Felix

Decreased blood pressure response in mice deficient 11589-11594 of the alb-adrenergic receptor

Antonella Cavalli, Anne-Laure Lattion, Edith Hummler, Monique Nenniger, Thierry Pedrazzini, Jean-Francois Aubert, Martin C. Michel, Ming Yang, Giuseppe Lembo, Carmine Vecchione, Marina Mostardini, Andrea Schmidt, Friedrich Beermann, and Susanna Cotecchia

Interferon f3 transduction of peripheral blood 11595-11600 lymphocytes from HIV-infected donors increases Thl-type cytokine production and improves the proliferative response to recall antigens

Vincent Vieillard, Isabelle Cremer, Evelyne Lauret, Willy Rozenbaum, Patrice Debre, Brigitte Autran, and Edward De Maeyer

Developmental disorder associated with increased 11601-11606 cellular nucleotidase activity

Theodore Page, Alice Yu, John Fontanesi, and William L. Nyhan

MICROBIOLOGY

Transmembrane /3-barrel of staphylococcal a-toxin 11607-11611 forms in sensitive but not in resistant cells

Angela Valeva, Iwan Walev, Matthias Pinkernell, Barbara Walker, Hagan Bayley, Michael Palmer, and Sucharit Bhakdi

x



Contents Binding of high-risk human papillomavirus E6 11612-11616 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein

Tohru Kiyono, Atsuro Hiraiwa, Masatoshi Fujita, Yasuyuki Hayashi, Tetsu Akiyama, and Masahide Ishibashi

Identification of a cellular receptor for subgroup E 11617-11622 avian leukosis virus

Heather B. Adkins, Jiirgen Brojatsch, John Naughton, Melissa M. Rolls, Jean M. Pesola, and John A. T. Young

Bordetella bronchiseptica dermonecrotizing toxin 11623-11626 induces reorganization of actin stress fibers through deamidation of Gln-63 of the GTP-binding protein Rho

Yasuhiko Horiguchi, Norimitsu Inoue, Minako Masuda, Takashige Kashimoto, Jun Katahira, Nakaba Sugimoto, and Morihiro Matsuda

NEUROBIOLOGY

Ca2+-independent inhibition of inositol trisphosphate 11627-11632 receptors by calmodulin: Redistribution of calmodulin as a possible means of regulating Ca2+ mobilization

Sandip Patel, Stephen A. Morris, Charles E. Adkins, Gerry O'Beirne, and Colin W. Taylor

Decoding temporally encoded sensory input by 11633-11638 cortical oscillations and thalamic phase comparators

Ehud Ahissar, Sebastian Haidarliu, and Miriam Zacksenhouse

Identification and characterization of a conserved 11639-11644 family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C (rdgC)

Patti M. Sherman, Hui Sun, Jennifer P. Macke, John Williams, Philip M. Smallwood, and Jeremy Nathans

A dominant form of inherited retinal degeneration 11645-11650 caused by a non-photoreceptor cell-specific mutation

Lei Li and John E. Dowling

A human intermediate conductance calcium-activated 11651-11656 potassium channel

Takahiro M. Ishii, Christopher Silvia, Birgit Hirschberg, Chris T. Bond, John P. Adelman, and James Maylie

Activation of a caspase 3-related cysteine protease is 11657-11662 required for glutamate-mediated apoptosis of cultured cerebellar granule neurons

Yansheng Du, Kelly R. Bales, Richard C. Dodel, Elizabeth Hamilton-Byrd, Jeffrey W. Horn, Dan L. Czilli, Linda K. Simmons, Binhui Ni, and Steven M. Paul

Multipotent neural precursors can differentiate 11663-11668 toward replacement of neurons undergoing targeted apoptotic degeneration in adult mouse neocortex

Evan Y. Snyder, Cliff Yoon, Jonathan D. Flax, and Jeffrey D. Macklis

Glyceraldehyde-3-phosphate dehydrogenase: 11669-11674 Nuclear translocation participates in neuronal and nonneuronal cell death

Akira Sawa, Adil A. Khan, Lynda D. Hester, and Solomon H. Snyder

Long-term potentiation activates the GAP-43 11675-11680 promoter: Selective participation of hippocampal mossy cells

Uk Namgung, Shogo Matsuyama, and Aryeh Routtenberg

PHARMACOLOGY

Massive targeting of liposomes, surface-modified 11681-11685 with anionized albumins, to hepatic endothelial cells

Jan A. A. M. Kamps, Henriette W. M. Morselt, Pieter J. Swart, Dick K. F. Meijer, and Gerrit L. Scherphof

Peptide analogue studies of the hypothalamic 11686-11691 neuropeptide Y receptor mediating pituitary adrenocorticotrophic hormone release

C. J. Small, D. G. A. Morgan, K. Meeran, M. M. Heath, I. Gunn, C. M. B. Edwards, J. Gardiner, G. M. Taylor, J. D. Hurley, M. Rossi, A. P. Goldstone, D. O'Shea, D. M. Smith, M. A. Ghatei, and S. R. Bloom

A peptide derived from an extracellular domain 11692-11697 selectively inhibits receptor internalization: Target sequences on insulin and insulin-like growth factor 1 receptors

Tatjana Naranda, Avram Goldstein, and Lennart Olsson

Regulation of the human ether-a-gogo related gene 11698-11703 (HERG) K+ channels by reactive oxygen species

Maurizio Taglialatela, Pasqualina Castaldo, Silvana lossa, Anna Pannaccione, Angela Fresi, Eckhard Ficker, and Lucio Annunziato

PHYSIOLOGY

Oxytocin releases atrial natriuretic peptide by 11704-11709 combining with oxytocin receptors in the heart

Jolanta Gutkowska, Marek Jankowski, Chantal Lambert, Suhayla Mukaddam-Daher, Hans H. Zingg, and Samuel M. McCann

A mouse model for the renal salt-wasting 11710-11715 syndrome pseudohypoaldosteronism

Edith Hummler, Pierre Barker, Colleen Talbot, Qing Wang, Chantal Verdumo, Barbara Grubb, John Gatzy, Michel Burnier, Jean-Daniel Horisberger, Friedrich Beermann, Richard Boucher, and Bernard C. Rossier

Phentolamine block of KATP channels is mediated 11716-11720 by Kir6.2

Peter Proks and Frances M. Ashcroft

PLANT BIOLOGY

Developmental changes in DNA methylation of 11721-11725 the two tobacco pollen nuclei during maturation

Edward J. Oakeley, Adriano Podestai, and Jean-Pierre Jost

xi



Contents T-strand integration in maize protoplasts after 11726-11730 codelivery of a T-DNA substrate and virulence genes

Genevieve Hansen, Raymond D. Shillito, and Mary-Dell Chilton

Arabidopsis thaliana mutants altered in 11731-11735 homologous recombination

Jean E. Masson and Jerzy Paszkowski

The heme oxygenase gene (pbsA) in the red alga 11736-11741 Rhodella violacea is discontinuous and transcriptionally activated during iron limitation

Catherine Richaud and G6rald Zabulon

PSYCHOLOGY

Long-term potentiation activates the GAP-43 11675-11680 promoter: Selective participation of hippocampal mossy cells

Uk Namgung, Shogo Matsuyama, and Aryeh Routtenberg

AUTHOR INDEX

INFORMATION FOR AUTHORS

SIZING WORKSHEET

SUBSCRIPTION FORM

COPYRIGHT ASSIGNMENT FORM

CLASSIFIED ADVERTISEMENT

Feature integration in pattern perception 11742-11746 Dennis M. Levi, Vineeta Sharma, and Stanley A. Klein

Social Sciences

ANTHROPOLOGY

Ape-like or hominid-like? The positional behavior 11747-11750 of Oreopithecus bambolii reconsidered

Meike Kohler and Salvador Moya-Sola

CORRECTION

BIOCHEMISTRY Supercoiling-dependent flexibility of 11751 adenosine-tract-containing DNA detected by a topological method

Hua Tsen and Stephen D. Levene

xv-xvii

xviii-xx

xxi

xxii

xxiii

xxvii

xii



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