Front Matter Source: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, No. 26 (Dec. 23, 1997), pp. i-xi Published by: National Academy of Sciences Stable URL: http://www.jstor.org/stable/43595 . Accessed: 04/05/2014 20:58 Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at . http://www.jstor.org/page/info/about/policies/terms.jsp . JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact [email protected]. . National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access to Proceedings of the National Academy of Sciences of the United States of America. http://www.jstor.org This content downloaded from 130.132.123.28 on Sun, 4 May 2014 20:58:49 PM All use subject to JSTOR Terms and Conditions
Transcript
Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 94, No. 26 (Dec. 23, 1997), pp. i-xiPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/43595 .
Accessed: 04/05/2014 20:58
Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at .http://www.jstor.org/page/info/about/policies/terms.jsp
.JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range ofcontent in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new formsof scholarship. For more information about JSTOR, please contact [email protected].
.
National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access toProceedings of the National Academy of Sciences of the United States of America.
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NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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Correspondence: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, NW, Washington, DC 20418 USA (via U.S. postal service) or 1055 Thomas Jefferson Street, NW, Suite FO2013, Washington, DC 20007 USA (via courier or express mail). E-mail: [email protected]. Information for Authors: See pp. xvii-xix (of this issue) or http://www.pnas.org. Copyright: Volumes 90-94, copyright (C 1993-1997 by THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, all rights reserved; Volumes 1-89, copyright as a collective work only [author(s) retains copyright to individual articles]. Requests for Permission: Address requests to reproduce material published in Volumes 1-89 to the original author(s); address other requests to the Permissions Office of the PROCEEDINGS, 2101 Constitution Avenue, NW, Washington, DC 20418 USA, FAX 202-625-4749. Please cite the exact material to be reprinted and state specifically where it will be used. Photocopies: The journal is registered with the Copyright Clearance Center, 222 Rosewood Drive, Danvers, MA 01923 USA, FAX 978-750-4470. Authorization to photocopy items for the internal or personal use of specific clients is granted by THE NATIONAL ACADEMY OF SCIENCES provided that the copier pays to the Center the fee stated in the code on the first page of each article. Microforms: Contact University Microfilms Inc., P.O. Box 1346, Ann Arbor, MI 48106-1346 USA. This journal is printed on acid-free paper effective with Volume 84, Issue 1. Subscriptions: Address subscription correspondence to the Circulation Office of the PROCEEDINGS, 2101 Constitution Avenue, NW, Washington, DC 20418 USA. Subscriptions are entered on a calendar-year basis only. The 1997 subscription rates are as follows-in the U.S.: student, $90; postdoctoral, $125; personal, $150; institutional, $615-elsewhere by surface mail: student, $190; postdoctoral, $225; personal, $250; institutional, $715-elsewhere by expedited delivery at a surcharge of $234. Air mail rates available on request. Exclusive Agent for Subscribers in Japan: USACO Corporation, 13-12, Shimbashi, 1-Chome, Minato-ku, Tokyo 105 Japan. Change of Address: Notify the Circulation Office 6 weeks in advance and list the old and new addresses. The Academy is not responsible for nonreceipt of issues because of an improper address, unless a change of address is on file. Claims: Requests for replacement copies will not be honored more than 60 days after the issue date for domestic subscribers and not more than 90 days after the issue date for foreign subscribers. Claims will not be honored for more than 2 issues per calendar year for the same subscriber. Single Copies: $30 per issue in the U.S., $40 elsewhere. Canadian GST: Registration Number R-133130880. Advertising: Contact FASEB AdNet, 9650 Rockville Pike, Bethesda, MD 20814-3998 USA. Phone 800-43-FASEB X7103 or 301-530-7103, FAX 301-571-0683. Postmaster: Send address changes to PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, NW, Washington, DC 20418 USA. Periodicals postage paid at Washington, DC, and additional mailing offices. PRINTED IN THE USA
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Contents Design of potent and selective human cathepsin K 14249-14254 inhibitors that span the active site
Scott K. Thompson, Stacie M. Halbert, Mary J. Bossard, Thaddeus A. Tomaszek, Mark A. Levy, Baoguang Zhao, Ward W. Smith, Sherin S. Abdel-Meguid, Cheryl A. Janson, Karla J. D'Alessio, Michael S. McQueney, Bernard Y. Amegadzie, Charles R. Hanning, Renee L. DesJarlais, Jacques Briand, Susanta K. Sarkar, Michael J. Huddleston, Carl F. Ijames, Steven A. Carr, Keith T. Garnes, Art Shu, J. Richard Heys, Jeremy Bradbeer, Denise Zembryki, Liz Lee-Rykaczewski, Ian E. James, Michael W. Lark, Fred H. Drake, Maxine Gowen, John G. Gleason, and Daniel F. Veber
ENGINEERING
The degree of nonlinearity and anisotropy of blood 14255-14260 vessel elasticity
J. Zhou and Y. C. Fung
Biological Sciences
AGRICULTURAL SCIENCES
Comparative mapping of Andropogoneae: 14261-14266 Saccharum L. (sugarcane) and its relation to sorghum and maize
Claudia T. Guimaraes, Gavin R. Sills, and Bruno W. S. Sobral
BIOCHEMISTRY
Design of potent and selective human cathepsin K 14249-14254 inhibitors that span the active site
Scott K. Thompson, Stacie M. Halbert, Mary J. Bossard, Thaddeus A. Tomaszek, Mark A. Levy, Baoguang Zhao, Ward W. Smith, Sherin S. Abdel-Meguid, Cheryl A. Janson, Karla J. D'Alessio, Michael S. McQueney, Bernard Y. Amegadzie, Charles R. Hanning, Renee L. DesJarlais, Jacques Briand, Susanta K. Sarkar, Michael J. Huddleston, Carl F. Ijames, Steven A. Carr, Keith T. Garnes, Art Shu, J. Richard Heys, Jeremy Bradbeer, Denise Zembryki, Liz Lee-Rykaczewski, Ian E. James, Michael W. Lark, Fred H. Drake, Maxine Gowen, John G. Gleason, and Daniel F. Veber
Structure and function in rhodopsin: Topology 14267-14272 of the C-terminal polypeptide chain in relation to the cytoplasmic loops
Kewen Cai, Ralf Langen, Wayne L. Hubbell, and H. Gobind Khorana
Structure and function in rhodopsin: Rhodopsin 14273-14278 mutants with a neutral amino acid at E134 have a partially activated conformation in the dark state
Jong-Myoung Kim, Christian Altenbach, Robin L. Thurmond, H. Gobind Khorana, and Wayne L. Hubbell
Identification of a prion protein epitope modulating 14279-14284 transmission of bovine spongiform encephalopathy prions to transgenic mice
Michael R. Scott, Jiri Safar, Glenn Telling, Oanh Nguyen, Darlene Groth, Marilyn Torchia, Ruth Koehler, Patrick Tremblay, Dirk Walther, Fred E. Cohen, Stephen J. DeArmond, and Stanley B. Prusiner
Molecular cloning and functional expression of a 14285-14290 human cDNA encoding translation initiation factor 6
Kausik Si, Jayanta Chaudhuri, Jorge Chevesich, and Umadas Maitra
Visualization of a peripheral stalk in V-type 14291-14293 ATPase: Evidence for the stator structure essential to rotational catalysis
E. J. Boekema, T. Ubbink-Kok, J. S. Lolkema, A. Brisson, and W. N. Konings
Expression cloning of cDNA encoding a human 14294-14299 /3-1,3-N-acetylglucosaminyltransferase that is essential for poly-N-acetyllactosamine synthesis
An essential component of a C-terminal domain 14300-14305 phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae
Jacques Archambault, Ross S. Chambers, Michael S. Kobor, Yuen Ho, Mireille Cartier, Diana Bolotin, Brenda Andrews, Caroline M. Kane, and Jack Greenblatt
Influenza hemagglutinin is spring-loaded by a 14306-14313 metastable native conformation
Chavela M. Carr, Charu Chaudhry, and Peter S. Kim
Hydrophobic sequence minimization of the 14314-14319 a-lactalbumin molten globule Lawren C. Wu and Peter S. Kim
Identification and characterization of a human 14320-14325 protein kinase related to budding yeast Cdc7p
Wei Jiang and Tony Hunter
The zntA gene of Escherichia coli encodes a 14326-14331 Zn(II)-translocating P-type ATPase
Christopher Rensing, Bharati Mitra, and Barry P. Rosen
Kinetic characterization of brush border 14332-14337 myosin-I ATPase
James D. Jontes, Ronald A. Milligan, Thomas D. Pollard, and E. Michael Ostap
Thermodynamic stability of wild-type and mutant 14338-14342 p53 core domain
Alex N. Bullock, Julia Henckel, Brian S. DeDecker, Christopher M. Johnson, Penka V. Nikolova, Mark R. Proctor, David P. Lane, and Alan R. Fersht
Explanation by the double-metal-ion mechanism of 14343-14348 catalysis for the differential metal ion effects on the cleavage rates of 5'-oxy and 5'-thio substrates by a hammerhead ribozyme
De-Min Zhou, Li-He Zhang, and Kazunari Taira
iv
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Contents Regulation of dopaminergic pathways by retinoids: 14349-14354 Activation of the D2 receptor promoter by members of the retinoic acid receptor-retinoid X receptor family
Tarek A. Samad, Wojciech Krezel, Pierre Chambon, and Emiliana Borrelli
In vitro selection for altered divalent metal 14355-14360 specificity in the RNase P RNA
Daniel N. Frank and Norman R. Pace
The anaphase inhibitor of Saccharomyces cerevisiae 14361-14366 Pdslp is a target of the DNA damage checkpoint pathway
Orna Cohen-Fix and Doug Koshland
Wild-type Escherichia coli grows on the chitin 14367-14371 disaccharide, N,N'-diacetylchitobiose, by expressing the cel operon
Nemat 0. Keyhani and Saul Roseman
Cloning and functional characterization of 14372-14377 mouse IKB?
Simos Simeonidis, Stanley Liang, Guoying Chen, and Dimitris Thanos
The replication initiation protein of the 14378-14382 broad-host-range plasmid RK2 is activated by the ClpX chaperone
Igor Konieczny and Donald R. Helinski
Archaeal-type lysyl-tRNA synthetase in the Lyme 14383-14388 disease spirochete Borrelia burgdorferi
Michael Ibba, James L. Bono, Patricia A. Rosa, and Dieter S6ll
RGS2/GOS8 is a selective inhibitor of Gqa function 14389-14393 Scott P. Heximer, Ned Watson, Maurine E. Linder, Kendall J. Blumer, and John R. Hepler
Inhibition of mRNA export in vertebrate cells by 14394-14399 nuclear export signal conjugates
Amy E. Pasquinelli, Maureen A. Powers, Elsebet Lund, Douglass Forbes, and James E. Dahlberg
Cloning and characterization of a corepressor and 14400-14405 potential component of the nuclear hormone receptor repression complex
Iris Zamir, Jessica Dawson, Robert M. Lavinsky, Christopher K. Glass, Michael G. Rosenfeld, and Mitchell A. Lazar
Chemical complementation identifies a proton 14406-14411 acceptor for redox-active tyrosine D in photosystem II
Sunyoung Kim, Jie Liang, and Bridgette A. Barry
BIOPHYSICS
Virus-sized self-assembling lamellar complexes 14412-14417 between plasmid DNA and cationic micelles promote gene transfer
Bruno Pitard, Olivier Aguerre, Marc Airiau, Anne-Marie Lachages, Tsiala Boukhnikachvili, Gerardo Byk, Catherine Dubertret, Christian Herviou, Daniel Scherman, Jean-FranXois Mayaux, and Joel Crouzet
Torsional directed walks, entropic elasticity, 14418-14422 and DNA twist stiffness
J. David Moroz and Philip Nelson
Flickering fusion pores comparable with initial 14423-14428 exocytotic pores occur in protein-free phospholipid bilayers
Alexandr Chanturiya, Leonid V. Chernomordik, and Joshua Zimmerberg
Folding thermodynamics of a model three-helix- 14429-14432 bundle protein
Yaoqi Zhou and Martin Karplus
Absence of a barrier to backwards rotation of the 14433-14437 bacterial flagellar motor demonstrated with optical tweezers
Richard M. Berry and Howard C. Berg
CELL BIOLOGY
Subunit structure of the mammalian 14438-14443 exocyst complex
Yun Kee, Jin-San Yoo, Christopher D. Hazuka, Karen E. Peterson, Shu-Chan Hsu, and Richard H. Scheller
Generation of secretable and nonsecretable 14444-14449 interleukin 15 isoforms through alternate usage of signal peptides
Yutaka Tagaya, Gloria Kurys, Tiffany A. Thies, Jacqueline M. Losi, Nazli Azimi, John A. Hanover, Richard N. Bamford, and Thomas A. Waldmann
Otogelin: A glycoprotein specific to the acellular 14450-14455 membranes of the inner ear
Martine Cohen-Salmon, Aziz El-Amraoui, Michel Leibovici, and Christine Petit
D-myo-Inositol 1,4,5,6-tetrakisphosphate produced 14456-14460 in human intestinal epithelial cells in response to Salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways
Lars Eckmann, Marco T. Rudolf, Andrzej Ptasznik, Carsten Schultz, Tao Jiang, Nora Wolfson, Roger Tsien, Joshua Fierer, Stephen B. Shears, Martin F. Kagnoff, and Alexis E. Traynor-Kaplan
Protein kinase A activity is required for the 14461-14466 budding of constitutive transport vesicles from the trans-Golgi network
Manuel Muiiiz, Maria Esther Martin, Josefina Hidalgo, and Angel Velasco
The mechanism of Golgi segregation during 14467-14470 mitosis is cell type-specific
Harold Stanley, Juan Botas, and Vivek Malhotra
Proper sorting of the cation-dependent mannose 14471-14476 6-phosphate receptor in endosomes depends on a pair of aromatic amino acids in its cytoplasmic tail
Anja Schweizer, Stuart Kornfeld, and Jack Rohrer
A role for the epithelial-cell-specific tyrosine kinase 14477-14482 Sik during keratinocyte differentiation
Valeri Vasioukhin and Angela L. Tyner
v
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Localization of a constitutively active, phagocyte-like 14483-14488 NADPH oxidase in rabbit aortic adventitia: Enhancement by angiotensin II
Patrick J. Pagano, Justin K. Clark, M. Eugenia Cifuentes-Pagano, Stacie M. Clark, Gayle M. Callis, and Mark T. Quinn
Receptors induce chemotaxis by releasing the /3y 14489-14494 subunit of Gi, not by activating Gq or G,
Enid R. Neptune and Henry R. Bourne
Chemotaxis in a lymphocyte cell line transfected 14495-14499 with C-C chemokine receptor 2B: Evidence that directed migration is mediated by f3y dimers released by activation of Gai-coupled receptors
Hidenori Arai, Chia-Lin Tsou, and Israel F. Charo
Phosphorylation of the immunosuppressant 14500-14505 FK506-binding protein FKBP52 by casein kinase II: Regulation of HSP90-binding activity of FKBP52
Aneuploidy correlated 100% with chemical 14506-14511 transformation of Chinese hamster cells
Ruhong Li, George Yerganian, Peter Duesberg, Alwin Kraemer, Andreas Willer, Charlotte Rausch, and Ruediger Hehlmann
DEVELOPMENTAL BIOLOGY
Targeted disruption of the murine dihydrolipoamide 14512-14517 dehydrogenase gene (Dld) results in perigastrulation lethality
Mark T. Johnson, Hsin-Sheng Yang, Terry Magnuson, and Mulchand S. Patel
Conserved biological function between Pax-2 and 14518-14523 Pax-5 in midbrain and cerebellum development: Evidence from targeted mutations
Martin Schwarz, Gonzalo Alvarez-Bolado, Pavel Urbanek, Meinrad Busslinger, and Peter Gruss
A multimeric complex and the nuclear targeting of 14524-14529 the Drosophila Rel protein Dorsal
Jun Yang and Ruth Steward
ECOLOGY
Benthic-pelagic links and rocky intertidal 14530-14535 communities: Bottom-up effects on top-down control?
Bruce A. Menge, Bryon A. Daley, Patricia A. Wheeler, Elizabeth Dahlhoff, Eric Sanford, and P. Ted Strub
EVOLUTION
Evolutionary instability of the major 14536-14541 histocompatibility complex class I loci in New World primates
Luis F. Cadavid, Clare Shufflebotham, Francisco J. Ruiz, Meredith Yeager, Austin L. Hughes, and David I. Watkins
Asian genotypes of JC virus in Native Americans 14542-14546 and in a Pacific Island population: Markers of viral evolution and human migration
Hansjurgen T. Agostini, Richard Yanagihara, Victor Davis, Caroline F. Ryschkewitsch, and Gerald L. Stoner
GENETICS
In vivo gene delivery to the liver using reconstituted 14547-14552 chylomicron remnants as a novel nonviral vector
Toshifumi Hara, Yadi Tan, and Leaf Huang
Meisl and pKnoxl bind DNA cooperatively with 14553-14558 Pbxl utilizing an interaction surface disrupted in oncoprotein E2a-Pbxl
Paul S. Knoepfler, Katherine R. Calvo, Haiming Chen, Stylianos E. Antonarakis, and Mark P. Kamps
Spatio-temporally controlled site-specific somatic 14559-14563 mutagenesis in the mouse
Jacques Brocard, Xavier Warot, Olivia Wendling, Nadia Messaddeq, Jean-Luc Vonesch, Pierre Chambon, and Daniel Metzger
In vitro reconstruction of the Aspergillus 14564-14569 (= Emericella) nidulans genome
Rolf A. Prade, James Griffith, Krys Kochut, Jonathan Arnold, and William E. Timberlake
Plasmon analyses of Triticum (wheat) and Aegilops: 14570-14577 PCR-single-strand conformational polymorphism (PCR-SSCP) analyses of organellar DNAs
Gui-Zhi Wang, Naohiko T. Miyashita, and Koichiro Tsunewaki
Genomic and cDNA sequence analysis of the cell 14578-14583 matrix adhesion regulator gene
H. Durbin, M. R. Novelli, and W. F. Bodmer
Sequence of the FRA3B common fragile region: 14584-14589 Implications for the mechanism of FHIT deletion
Hiroshi Inoue, Hideshi Ishii, Hansjuerg Alder, Eric Snyder, Teresa Druck, Kay Huebner, and Carlo M. Croce
Loss of p21 increases sensitivity to ionizing radiation 14590-14595 and delays the onset of lymphoma in atm-deficient mice
Y. Alan Wang, Ari Elson, and Philip Leder
The restriction-modification genes of Escherichia 14596-14601 coli K-12 may not be selfish: They do not resist loss and are readily replaced by alleles conferring different specificities
Mary O'Neill, Angela Chen, and Noreen E. Murray
Protamine-Cre recombinase transgenes efficiently 14602-14607 recombine target sequences in the male germ line of mice, but not in embryonic stem cells
Stephen O'Gorman, Nicole A. Dagenais, Min Qian, and Yelena Marchuk
vi
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Comparative mapping of the human 22qll 14608-14613 chromosomal region and the orthologous region in mice reveals complex changes in gene organization
Anne Puech, Bruno Saint-Jore, Birgit Funke, Debra J. Gilbert, Howard Sirotkin, Neal G. Copeland, Nancy A. Jenkins, Raju Kucherlapati, Bernice Morrow, and Arthur I. Skoultchi
IMMUNOLOGY
Drosophila host defense: Differential induction of 14614-14619 antimicrobial peptide genes after infection by various classes of microorganisms
Bruno Lemaitre, Jean-Marc Reichhart, and Jules A. Hoffmann
Identification of functional domains on human 14620-14625 interleukin 10
Borbala Gesser, Henrik Leffers, Tan Jinquan, Christian Vestergaard, Nicka Kirstein, Steen Sindet-Pedersen, Steen Lindkaer Jensen, Kristian Thestrup-Pedersen, and Christian Gr0nh0j Larsen
DNA immunization: Induction of higher avidity 14626-14631 antibody and effect of route on T cell cytotoxicity
Jefferey S. Boyle, Anabel Silva, Jamie L. Brady, and Andrew M. Lew
Purified hematopoietic stem cells without facilitating 14632-14636 cells can repopulate fully allogeneic recipients across entire major histocompatibility complex transplantation barrier in mice
Bing-yan Wang, Nagwa S. El-Badri, Cherry, and Robert A. Good
Mice transgenic for human CD4 and CCR5 are 14637-14641 susceptible to HIV infection
Jessie Browning, James W. Horner, Massimo Pettoello-Mantovani, Christina Raker, Sergey Yurasov, Ronald A. DePinho, and Harris Goldstein
Superactivation of an immune response triggered 14642-14647 by oligomerized T cell epitopes
Olaf Rotzschke, Kirsten Falk, and Jack L. Strominger
Role of B cells in antigen presentation of the 14648-14653 hepatitis B core
David R. Milich, Margaret Chen, Florian Sch6del, Darrell L. Peterson, Joyce E. Jones, and Janice L. Hughes
Role of the major histocompatibility complex 14654-14659 class II Ea gene in lupus susceptibility in mice
Nabila Ibnou-Zekri, Masahiro Iwamoto, Liliane Fossati, Patricia J. McConahey, and Shozo Izui
Protective anti-tumor immunity induced by 14660-14665 vaccination with recombinant adenoviruses encoding multiple tumor-associated cytotoxic T lymphocyte epitopes in a string-of-beads fashion
Ren6 E. M. Toes, Rob C. Hoeben, Ellen I. H. van der Voort, Maaike E. Ressing, Alex J. van der Eb, Cornelis J. M. Melief, and Rienk Offringa
Multiple receptors for HLA-G on human natural 14666-14670 killer cells
0. Mandelboim, L. Pazmany, D. M. Davis, M. Vales-G6mez, H. T. Reyburn, B. Rybalov, and J. L. Strominger
WIP, a protein associated with Wiskott-Aldrich 14671-14676 syndrome protein, induces actin polymerization and redistribution in lymphoid cells
Narayanaswamy Ramesh, In6s M. Ant6n, John H. Hartwig, and Raif S. Geha
Combined transgenic expression of ae-galactosidase 14677-14682 and al,2-fucosyltransferase leads to optimal reduction in the major xenoepitope Gala(1,3)Gal
Narin Osman, Ian F. C. McKenzie, Karen Ostenried, Yiannis A. Ioannou, Robert J. Desnick, and Mauro S. Sandrin
MEDICAL SCIENCES
The anticoagulant activation of antithrombin 14683-14688 by heparin
Lei Jin, Jan Pieter Abrahams, Richard Skinner, Maurice Petitou, Robert N. Pike, and Robin W. Carrell
Expression of lipocalin-type prostaglandin D 14689-14694 synthase (/3-trace) in human heart and its accumulation in the coronary circulation of angina patients
Development of an epithelium-specific expression 14695-14700 cassette with human DNA regulatory elements for transgene expression in lung airways
Yu-Hua Chow, Hugh O'Brodovich, Jonathan Plumb, Yanxia Wen, Kyoung-Jin Sohn, Zhan Lu, Fangyuan Zhang, Gergely L. Lukacs, A. Keith Tanswell, Chi-Chung Hui, Manuel Buchwald, and Jim Hu
Regulated expression of the diphtheria toxin A 14701-14706 chain by a tumor-specific chimeric transcription factor results in selective toxicity for alveolar rhabdomyosarcoma cells
Edmond S. Massuda, Edward J. Dunphy, Rebecca A. Redman, Jennifer J. Schreiber, Lauren E. Nauta, Frederic G. Barr, Ian H. Maxwell, and Timothy P. Cripe
Hepatitis B virus X protein and p53 tumor 14707-14712 suppressor interactions in the modulation of apoptosis
Lynne W. Elmore, Amy R. Hancock, Shau-Feng Chang, Xin W. Wang, Seung Chang, Christiana P. Callahan, David A. Geller, Hans Will, and Curtis C. Harris
Identification of semaphorin E as a non-MDR drug 14713-14718 resistance gene of human cancers
Tesshi Yamada, Ritsuko Endo, Masahiro Gotoh, and Setsuo Hirohashi
Analysis of genomic alterations in benign, atypical, 14719-14724 and anaplastic meningiomas: Toward a genetic model of meningioma progression
Ruthild G. Weber, Jan Bostrom, Marietta Wolter, Michael Baudis, V. Peter Collins, Guido Reifenberger, and Peter Lichter
vii
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Contents In vivo NMR and MRI using injection delivery of 14725-14729 laser-polarized xenon
B. M. Goodson, Y.-Q. Song, R. E. Taylor, V. D. Schepkin, K. M. Brennan, G. C. Chingas, T. F. Budinger, G. Navon, and A. Pines
Hypertension, cardiac hypertrophy, and sudden death 14730-14735 in mice lacking natriuretic peptide receptor A
Paula M. Oliver, Jennifer E. Fox, Ron Kim, Howard A. Rockman, Hyung-Suk Kim, Robert L. Reddick, Kailash N. Pandey, Sharon L. Milgram, Oliver Smithies, and Nobuyo Maeda
a+-Thalassemia protects children against disease 14736-14741 caused by other infections as well as malaria
S. J. Allen, A. O'Donnell, N. D. E. Alexander, M. P. Alpers, T. E. A. Peto, J. B. Clegg, and D. J. Weatherall
CD4-independent, CCR5-dependent infection of 14742-14747 brain capillary endothelial cells by a neurovirulent simian immunodeficiency virus strain
Aimee L. Edinger, Joseph L. Mankowski, Benjamin J. Doranz, Barry J. Margulies, Benhur Lee, Joseph Rucker, Matthew Sharron, Trevor L. Hoffman, Joanne F. Berson, M. Christine Zink, Vanessa M. Hirsch, Janice E. Clements, and Robert W. Doms
Genetically determined chloride-sensitive 14748-14752 hypertension and stroke
Masae Tanaka, Olga Schmidlin, Sai-Li Yi, Andrew W. Bollen, and R. Curtis Morris, Jr.
p53CP, a putative p53 competing protein that 14753-14758 specifically binds to the consensus p53 DNA binding sites: A third member of the p53 family?
Junhui Bian and Yi Sun
MICROBIOLOGY
Influenza hemagglutinin is spring-loaded by a 14306-14313 metastable native conformation
Chavela M. Carr, Charu Chaudhry, and Peter S. Kim
Cloning and mutagenesis of a herpesvirus genome 14759-14763 as an infectious bacterial artificial chromosome
Martin Messerle, Irena Crnkovic, Wolfgang Hammerschmidt, Heike Ziegler, and Ulrich H. Koszinowski
A system for functional analysis of 14764-14769 Ebola virus glycoprotein
Ayato Takada, Clinton Robison, Hideo Goto, Anthony Sanchez, K. Gopal Murti, Michael A. Whitt, and Yoshihiro Kawaoka
NEUROBIOLOGY
N-methyl-D-aspartate receptor activation and visual 14770-14775 activity induce elongation factor-2 phosphorylation in amphibian tecta: A role for N-methyl-D-aspartate receptors in controlling protein synthesis
A. J. Scheetz, Angus C. Nairn, and Martha Constantine-Paton
Targeted deletion of all isoforms of the trkC gene 14776-14781 suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesis
Lino Tessarollo, Pantelis Tsoulfas, Michael J. Donovan, Mary Ellen Palko, Janet Blair-Flynn, Barbara L. Hempstead, and Luis F. Parada
Ca2+-dependent and -independent interactions of 14782-14786 the isoforms of the alA subunit of brain Ca2+ channels with presynaptic SNARE proteins
D. Kyle Kim and William A. Catterall
A new mechanism of sound generation in songbirds 14787-14791 Franz Goller and Ole N. Larsen
Role of left inferior prefrontal cortex in retrieval of 14792-14797 semantic knowledge: A reevaluation
Sharon L. Thompson-Schill, Mark D'Esposito, Geoffrey K. Aguirre, and Martha J. Farah
A sensory brain map for each behavior? 14798-14803 W. Metzner and J. Juranek
Neurotrophin-3 signals redistribute RNA in neurons 14804-14808 Roger B. Knowles and Kenneth S. Kosik
In vitro-generated neural precursors participate in 14809-14814 mammalian brain development
Oliver Briistle, A. Cyril Spiro, Khalad Karram, Khalid Choudhary, Shigeo Okabe, and Ronald D. G. McKay
Interactive cloning with the SH3 domain of N-src 14815-14820 identifies a new brain specific ion channel protein, with homology to Eag and cyclic nucleotide-gated channels
Bina Santoro, Seth G. N. Grant, Dusan Bartsch, and Eric R. Kandel
Glutamate transporter currents in Bergmann 14821-14825 glial cells follow the time course of extrasynaptic glutamate
Dwight E. Bergles, Jeffrey A. Dzubay, and Craig E. Jahr
Vascular imprints of neuronal activity: Relationships 14826-14831 between the dynamics of cortical blood flow, oxygenation, and volume changes following sensory stimulation
Targeted gene deletion of heme oxygenase 2 14848-14853 reveals neural role for carbon monoxide
Randa Zakhary, Kenneth D. Poss, Samie R. Jaffrey, Christopher D. Ferris, Susumu Tonegawa, and Solomon H. Snyder
Orphanin FO acts as an anxiolytic to attenuate 14854-14858 behavioral responses to stress
Francois Jenck, Jean-Luc Moreau, James R. Martin, Gavin J. Kilpatrick, Rainer K. Reinscheid, Frederick J. Monsma, Jr., Hans-Peter Nothacker, and Olivier Civelli
The phosphoprotein DARPP-32 mediates 14859-14864 cAMP-dependent potentiation of striatal N-methyl-D-aspartate responses
Thomas Blank, Ingrid Nijholt, Ulrich Teichert, Heidemarie Kiigler, Holger Behrsing, Allen Fienberg, Paul Greengard, and Joachim Spiess
Neurosteroids: Deficient cognitive performance in 14865-14870 aged rats depends on low pregnenolone sulfate levels in the hippocampus
Monique Vallee, Willy Mayo, Muriel Darnaudery, Colette Corpechot, Jacques Young, Muriel Koehl, Michel Le Moal, Etienne-Emile Baulieu, Paul Robel, and Herve Simon
Block of transmitter release by botulinum Cl action 14871-14876 on syntaxin at the squid giant synapse
Jordi Marsal, Bonaventura Ruiz-Montasell, Joan Blasi, Jorge E. Moreira, Diego Contreras, Mutsuyuki Sugimori, and Rodolfo Llinas
Transient "deafness" accompanies auditory 14877-14882 development during metamorphosis from tadpole to frog
Seth S. Boatright-Horowitz and Andrea Megela Simmons
Predominance of the alD subunit in L-type 14883-14888 voltage-gated Ca2+ channels of hair cells in the chicken's cochlea
Richard Kollmar, Lisa G. Montgomery, John Fak, Lisa J. Henry, and A. J. Hudspeth
Hair cell-specific splicing of mRNA for the alD 14889-14893 subunit of voltage-gated Ca2+ channels in the chicken's cochlea
Richard Kollmar, John Fak, Lisa G. Montgomery, and A. J. Hudspeth
Apparent mtDNA heteroplasmy in Alzheimer's 14894-14899 disease patients and in normals due to PCR amplification of nucleus-embedded mtDNA pseudogenes
Michio Hirano, Alexander Shtilbans, Richard Mayeux, Mercy M. Davidson, Salvatore DiMauro, James A. Knowles, and Eric A. Schon
Ancient mtDNA sequences in the human nuclear 14900-14905 genome: A potential source of errors in identifying pathogenic mutations
Douglas C. Wallace, Carol Stugard, Deborah Murdock, Theodore Schurr, and Michael D. Brown
PHARMACOLOGY
Construction of a high-affinity receptor site for 14906-14911 dihydropyridine agonists and antagonists by single amino acid substitutions in a non-L-type Ca2+ channel
Gregory H. Hockerman, Blaise Z. Peterson, Elizabeth Sharp, Timothy N. Tanada, Todd Scheuer, and William A. Catterall
Loperamide: A positive modulator for store-operated 14912-14917 calcium channels?
Jacquie L. Harper, Yangmee Shin, and John W. Daly
PHYSIOLOGY
Inactivation of calcium-activated chloride channels 14918-14923 in smooth muscle by calcium/calmodulin-dependent protein kinase
Yong-Xiao Wang and Michael I. Kotlikoff
113-Hydroxysteroid dehydrogenase type 1 14924-14929 knockout mice show attenuated glucocorticoid- inducible responses and resist hyperglycemia on obesity or stress
Yuri Kotelevtsev, Megan C. Holmes, Ann Burchell, Pamela M. Houston, Dieter Schmoll, Pauline Jamieson, Ruth Best, Roger Brown, Christopher R. W. Edwards, Jonathan R. Seckl, and John J. Mullins
Slow and fast dietary proteins differently modulate 14930-14935 postprandial protein accretion
Yves Boirie, Martial Dangin, Pierre Gachon, Marie-Paule Vasson, Jean-Louis Maubois, and Bernard Beaufrere
Antisense oligonucleotides against rat brain alE 14936-14941 DNA and its atrial homologue decrease T-type calcium current in atrial myocytes
Erika S. Piedras-Renterfa, Chien-Chang Chen, and Philip M. Best
Anchoring of protein kinase A facilitates 14942-14947 hormone-mediated insulin secretion
Linda B. Lester, Lorene K. Langeberg, and John D. Scott
PLANT BIOLOGY
Leaf-specifically expressed genes for polypeptides 14948-14953 destined for chloroplasts with domains of o-70 factors of bacterial RNA polymerases in Arabidopsis thaliana
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