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Front Matter Source: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, No. 25 (Dec. 8, 1998), pp. i-xii Published by: National Academy of Sciences Stable URL: http://www.jstor.org/stable/46584 . Accessed: 06/05/2014 06:40 Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at . http://www.jstor.org/page/info/about/policies/terms.jsp . JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact [email protected]. . National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access to Proceedings of the National Academy of Sciences of the United States of America. http://www.jstor.org This content downloaded from 62.122.77.88 on Tue, 6 May 2014 06:40:32 AM All use subject to JSTOR Terms and Conditions
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Page 1: Front Matter

Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 95, No. 25 (Dec. 8, 1998), pp. i-xiiPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/46584 .

Accessed: 06/05/2014 06:40

Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at .http://www.jstor.org/page/info/about/policies/terms.jsp

.JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range ofcontent in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new formsof scholarship. For more information about JSTOR, please contact [email protected].

.

National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access toProceedings of the National Academy of Sciences of the United States of America.

http://www.jstor.org

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Page 2: Front Matter

PROEED)T*INGS OF THE

NAT~~~(IONAL IACADEMY ; OFr SCIENCES;

OF THE~,T UNTED--- - STTE OF-- AMERICA -

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Page 3: Front Matter

TM A ~~~~~TM

2 04

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PathwaysM 20adto new versions oouhmaGNEITRST ae now availab)le. A version ofi GENEFILTERST consisting entirely Of Known genes (over 4,000 on one membrane), anid the newest installment (Release III) in our huMan GEN-FiLTERSMseries can now b)e purchaseda. The Release Ill installmenit ~contains sequence validated known and unknown genes and brings the total numiber of sequence validated gee vilable oni GENEFILERT to over 15,000. GENEfFLTtERST are highi dnsity DNA arrays producedi onl 5cm x 7cm membranes. These new tools .Offer the opportunity to carry out soph'isticated, genome-wide gene expression experimentts uising simple autoradiography w-ith or without phosphor imaging equipment. GENEFITEST can be probed uptio s6ix time6s. Stcantdard hybridization methods with 321P or 33]produce data which can be analyzed by hand or by using PathwaysT, ou6ir image analysissftae Human releases 1, II, and ill consist of DNA from 5,184 unhique, sequence validated, I.M.AG.E./LLNLI clones chosen firom the unigene st2For a complete descriptioni of each of the GENEFILTERSTM , please see our web site at http://www.resgen.com.

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Ref 1. Lennon,n G., Auiffray C., Polymerooulos, M., Soares, M.B. (1996) Genomics 33, 151 152. 2. http:Hlwww4.ncbi.nlm.nih.gov/UniiGene/in&ex.htmlI

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Page 4: Front Matter

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Page 5: Front Matter

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Page 6: Front Matter

PROCEEDINGS OF THE

NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Officers of the Academy

BRUCE ALBERTS, President JACK HALPERN, Vice President PETER H. RAVEN, Home Secretary F. SHERWOOD ROWLAND, Foreign Secretary RONALD L. GRAHAM, Treasurer

Editor-in-Chief NICHOLAS R. COZZARELLI

Editorial Board of the Proceedings

MAY R. BERENBAUM CHARLES FEFFERMAN PHIL W. MAJERUS CARLA J. SHATZ PETER J. BICKEL WALTER M. FITCH PHILIPPA MARRACK KAI L. SIMONS MARIO R. CAPECCHI JOSEPH L. GOLDSTEIN RICHARD D. MCKELVEY CHRISTOPHER A. SIMS WILLIAM CATrERALL CAROL A. GROSS ARNO G. MOTULSKY SOLOMON H. SNYDER ANTHONY CERAMI JACK HALPERN RONALD L. PHILLIPS CHRISTOPHER R. SOMERVILLE PIERRE CHAMBON BERTIL HILLE THOMAS D. POLLARD LARRY R. SQUIRE MARSHALL H. COHEN PIERRE C. HOHENBERG STANLEY B. PRUSINER STEVEN M. STANLEY STANLEY N. COHEN H. ROBERT HORVITZ CHARLES RADDING CHARLES F. STEVENS DAVID R. DAVIES ERICH P. IPPEN GIAN-CARLO ROTA FRANK H. STILLINGER HERMAN N. EISEN ALFRED G. KNUDSON JEREMY A. SABLOFF KARL K. TUREKIAN RAYMOND L. ERIKSON ROGER KORNBERG PAUL R. SCHIMMEL DON C. WILEY ANTHONY S. FAUCI ROBERT LANGER STUART L. SCHREIBER PETER G. WOLYNES NINA FEDOROFF HARVEY F. LODISH AARON J. SHATKIN

Publisher: KENNETH R. FULTON Managing Editor: DIANE M. SULLENBERGER Associate Editorial Manager: JOHN M. MALLOY Associate Recruiting Editor: GuY RIDDIHOUGH Associate Manager for Production: JOANNE D'AMIco Production Coordinator: BARBARA A. BACON Editorial Coordinators: JOAN M. DAWSON, AZADEH FULLMER, DANIEL H. SALSBURY Editorial Assistants: DORIS DIASE, ELISA GRAY, JOE N. HARPE, RENITA M. JOHNSON,

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (ISSN-0027-8424) is published biweekly by THE NATIONAL ACADEMY OF SCIENCES. Correspondence: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, NW, Washington, DC 20418 USA (via U.S. postal service) or 1055 Thomas Jefferson Street, NW, Suite F02013, Washington, DC 20007 USA (via courier or express mail). E-mail: [email protected]. Information for Authors: See pp. xvi-xviii (of this issue) or www.pnas.org.

Copyright: Volumes 90-95, copyright C) 1993-1998 by THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, all rights reserved; Volumes 1-89, copyright as a collective work only [author(s) retains copyright to individual articles]. Requests for Permission: Address requests to reproduce material published in Volumes 1-89 to the original author(s); address other requests to the Permissions Office of the PROCEEDINGS, 2101 Constitution Avenue, NW, Washington, DC 20418 USA, FAX 1-202-334-2739. Please cite the exact material to be reprinted and state specifically where it will be used. Photocopies: The journal is registered with the Copyright Clearance Center, 222 Rosewood Drive, Danvers, MA 01923 USA, FAX 1-978-750-4470. Authorization to photocopy items for the internal or personal use of specific clients is granted by THE NATIONAL ACADEMY OF SCIENCES provided that the copier pays to the Center the fee stated in the code on the first page of each article. Microforms: Contact University Microfilms Inc., P.O. Box 1346, Ann Arbor, MI 48106-1346 USA. This journal is printed on acid-free paper effective with Volume 84, Issue 1. Subscriptions: Address subscription correspondence to the Circulation Office of the PROCEEDINGS, 2101 Constitution Avenue, NW, Washington, DC 20418 USA. Subscriptions are entered on a calendar-year basis only. The 1998 subscription rates for print only/online only/print plus online are as follows-in the U.S.: student, $90/$50/$110; postdoctoral, $125/$50/$150; personal, $165/$100/$195; institutional, $685/$615/$820-elsewhere (print by surface mail): student, $190/$50/$210; postdoctoral, $225/ $50/$250; personal, $265/$100/$295; institutional, $785/$615/$920-elsewhere by expedited delivery at a surcharge of $320. Air mail rates available on request. Exclusive Agent for Subscribers in Japan: USACO Corporation, 13-12, Shimbashi, 1-Chome, Minato-ku, Tokyo 105 Japan. Change ofAddress: Notify the Circulation Office 6 weeks in advance and list the old and new addresses. The Academy is not responsible for nonreceipt of issues because of an improper address, unless a change of address is on file. Claims: Requests for replacement copies will not be honored more than 60 days after the issue date for domestic subscribers and not more than 90 days after the issue date for foreign subscribers. Claims will not be honored for more than 2 issues per calendar year for the same subscriber. Single Copies: $30 per issue in the U.S., $40 elsewhere. Canadian GST: Registration Number R-133130880. Advertising: Contact M. J. Mrvica Associates, Inc., 2 West Taunton Avenue, Berlin, NJ 08009 USA. Phone 1-609-768-9360, FAX 1-609-753-0064, E-mail [email protected]. Postmaster: Send address changes to PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, NW, Washington, DC 20418 USA. Periodicals postage paid at Washington, DC, and additional mailing offices. PRINTED IN THE USA PROCEEDINGS OF THE NATIONAL ACADEMy OF SCIENCES is also available online at www.pnas.org.

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Page 7: Front Matter

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Page 8: Front Matter

PROCEEDINGS OF THE

NATIONAL ACADEMY OF SCIENCES

OF THE UNITED STATES OF AMERICA

December 8, 1998 Volume 95, Number 25 pp. 14587-15152

Table of Contents

Commentaries

Membrane protein biogenesis: The exception 14587-14589 explains the rules

Harris D. Bernstein * See companion article on page 14646

Bringing biological solutions to chemical problems 14590-14591 Peter G. Schultz * See companion article on page 14603

NO skeletal muscle derived relaxing factor in 14592-14593 Duchenne muscular dystrophy

David S. Bredt * See companion article on page 15090

Inaugural Articles

Comparative analyses of the secondary structures 14614-14621 of synthetic and intracellular yeast MFA2 mRNAs

Mitchel J. Doktycz, Frank W. Larimer, Miro Pastrnak, and Audrey Stevens

Fractionation factors and activation energies for 14664-14668 exchange of the low barrier hydrogen bonding proton in peptidyl trifluoromethyl ketone complexes of chymotrypsin

Jing Lin, William M. Westler, W. Wallace Cleland, John L. Markley, and Perry A. Frey

Physical Sciences

APPLIED MATHEMATICS

Compression, gain, and nonlinear distortion in 14594-14599 an active cochlear model with subpartitions

R. S. Chadwick

Matchings and phylogenetic trees 14600-14602 Persi W. Diaconis and Susan P. Holmes

CHEMISTRY

The antibody catalysis route to the total synthesis 14603-14608 of epothilones

Subhash C. Sinha, Carlos F. Barbas, III, and Richard A. Lerner * See Commentary on page 14590

Biological Sciences

BIOCHEMISTRY

Isolation and one-step preparation of A2E and 14609-14613 iso-A2E, fluorophores from human retinal pigment epithelium

Craig A. Parish, Masaru Hashimoto, Koji Nakanishi, James Dillon, and Janet Sparrow

v

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Page 9: Front Matter

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Page 10: Front Matter

Contents

Comparative analyses of the secondary structures 14614-14621 of synthetic and intracellular yeast MFA2 mRNAs

Mitchel J. Doktycz, Frank W. Larimer, Miro Pastrnak, and Audrey Stevens

Localization of the N terminus of hepatitis B virus 14622-14627 capsid protein by peptide-based difference mapping from cryoelectron microscopy

J. F. Conway, N. Cheng, A. Zlotnick, S. J. Stahl, P. T. Wingfield, and A. C. Steven

Toward controlling gene expression at will: Specific 14628-14633 regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks

Roger R. Beerli, David J. Segal, Birgit Dreier, and Carlos F. Barbas, III

Identification and characterization of a 14634-14639 single-stranded DNA-binding protein from the archaeon Methanococcus jannaschii

Thomas J. Kelly, Pamela Simancek, and George S. Brush

Yeast chorismate mutase in the R state: 14640-14645 Simulations of the active site

Jianpeng Ma, Xiaofeng Zheng, Georg Schnappauf, Gerhard Braus, Martin Karplus and William N. Lipscomb

Differential use of the signal recognition particle 14646-14651 translocase targeting pathway for inner membrane protein assembly in Escherichia coli

Jan-Willem L. de Gier, Pier A. Scotti, Annika Saaf, Quido A. Valent, Andreas Kuhn, Joen Luirink, and Gunnar von Heijne * See Commentary on page 14587

Upstream A-tracts increase bacterial promoter 14652-14657 activity through interactions with the RNA polymerase ca subunit

Sarah E. Aiyar, Richard L. Gourse, and Wilma Ross

Structural assignments to the Mycoplasma 14658-14663 genitalium proteins show extensive gene duplications and domain rearrangements

Sarah A. Teichmann, Jong Park, and Cyrus Chothia

Fractionation factors and activation energies for 14664-14668 exchange of the low barrier hydrogen bonding proton in peptidyl trifluoromethyl ketone complexes of chymotrypsin

Jing Lin, William M. Westler, W. Wallace Cleland, John L. Markley, and Perry A. Frey

Derepression of human embryonic ;-globin 14669-14674 promoter by a locus-control region sequence

B.-L. Huang, I. R. Fan-Chiang, S. C. Wen, H.-C. Koo, W. Y. Kao, N. R. Gawa, and C.-K. James Shen

Semirational design of active tumor suppressor p53 14675-14680 DNA binding domain with enhanced stability

Penka V. Nikolova, Julia Henckel, David P. Lane, and Alan R. Fersht

Bax interacts with the permeability transition pore 14681-14686 to induce permeability transition and cytochrome c release in isolated mitochondria

Masashi Narita, Shigeomi Shimizu, Toshinori Ito, Thomas Chittenden, Robert J. Lutz, Hikaru Matsuda, and Yoshihide Tsujimoto

Double-stranded RNA induces mRNA degradation 14687-14692 in Trypanosoma brucei

Huan Ng6, Christian Tschudi, Keith Gull, and Elisabetta Ullu

Protein phosphatase 2A is required for the 14693-14698 initiation of chromosomal DNA replication

Xiao-Hong Lin, Johannes Walter, Karl Scheidtmann, Kim Ohst, John Newport, and Gernot Walter

Functional topography of nascent RNA in 14699-14704 elongation intermediates of RNA polymerase

Natalia Komissarova and Mikhail Kashlev

BIOPHYSICS

Compression, gain, and nonlinear distortion in an 14594-14599 active cochlear model with subpartitions

R. S. Chadwick

Identification of protein-protein interfaces by 14705-14710 decreased amide proton solvent accessibility

Jeffrey G. Mandell, Arnold M. Falick, and Elizabeth A. Komives

CELL BIOLOGY

Tissue phenotype depends on reciprocal interactions 14711-14716 between the extracellular matrix and the structural organization of the nucleus

Sophie A. Lelievre, Valerie M. Weaver, Jeffrey A. Nickerson, Carolyn A. Larabell, Ankan Bhaumik, Ole W. Petersen, and Mina J. Bissell

WISP genes are members of the connective tissue 14717-14722 growth factor family that are up-regulated in Wnt-1-transformed cells and aberrantly expressed in human colon tumors

Diane Pennica, Todd A. Swanson, James W. Welsh, Margaret A. Roy, David A. Lawrence, James Lee, Jennifer Brush, Lisa A. Taneyhill, Bethanne Deuel, Michael Lew, Colin Watanabe, Robert L. Cohen, Mona F. Melhem, Gene G. Finley, Phil Quirke, Audrey D. Goddard, Kenneth J. Hillan, Austin L. Gurney, David Botstein, and Arnold J. Levine

Dissociation among in vitro telomerase activity, 14723-14728 telomere maintenance, and cellular immortalization

Christopher M. Counter, William C. Hahn, Wenyi Wei, Stephanie Dickinson Caddle, Roderick L. Beijersbergen, Peter M. Lansdorp, John M. Sedivy, and Robert A. Weinberg

Cleavage planes in frog eggs are altered by strong 14729-14732 magnetic fields

James M. Denegre, James M. Valles, Jr., Kevin Lin, W. B. Jordan, and Kimberly L. Mowry

vii

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Page 11: Front Matter

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Page 12: Front Matter

Contents Apoprotein B100 has a prolonged interaction 14733-14738 with the translocon during which its lipidation and translocation change from dependence on the microsomal triglyceride transfer protein to independence

Deborah M. Mitchell, Mingyue Zhou, Rajalakshmi Pariyarath, Hongxing Wang, John D. Aitchison, Henry N. Ginsberg, and Edward A. Fisher

A cytosolic activity distinct from Crml mediates 14739-14744 nuclear export of protein kinase inhibitor in permeabilized cells

James M. Holaska and Bryce M. Paschal

PAT1, a microtubule-interacting protein, recognizes 14745-14750 the basolateral sorting signal of amyloid precursor protein

Peizhong Zheng, Jean Eastman, Scott Vande Pol, and Sanjay W. Pimplikar

Thiazolidinediones and insulin resistance: 14751-14756 Peroxisome proliferator-activated receptor y activation stimulates expression of the CAP gene

Vered Ribon, John H. Johnson, Heidi S. Camp, and Alan R. Saltiel

Attachment to the nuclear matrix mediates specific 14757-14762 alterations in chromatin structure

Alexander Pemov, Sergei Bavykin, and Joyce L. Hamlin

Telomerase expression in chickens: Constitutive 14763-14768 activity in somatic tissues and down-regulation in culture

Ranga N. Venkatesan and Carolyn Price

SMAD3/4-dependent transcriptional activation of 14769-14774 the human type VII collagen gene (COL7A1) promoter by transforming growth factor 3

Laurence Vindevoghel, Robert J. Lechleider, Atsushi Kon, Mark P. de Caestecker, Jouni Uitto, Anita B. Roberts, and Alain Mauviel

A p53-dependent S-phase checkpoint helps to 14775-14780 protect cells from DNA damage in response to starvation for pyrimidine nucleotides

Munna L. Agarwal, Archana Agarwal, William R. Taylor, Olga Chernova, Yogesh Sharma, and George R. Stark

Negative regulation of mitosis in fission yeast by 14781-14786 the Shkl-interacting protein Skbl and its human homolog, SkblHs

Mary Gilbreth, Peirong Yang, Geoffrey Bartholomeusz, Ruth A. Pimental, Sanjay Kansra, Ramesh Gadiraju, and Stevan Marcus

Pontin52, an interaction partner of 3-catenin, 14787-14792 binds to the TATA box binding protein

Andreas Bauer, Otmar Huber, and Rolf Kemler

Mobility of cytochrorne P450 in the endoplasmic 14793-14798 reticulum membrane

Elzbieta Szczesna-Skorupa, Ci-Di Chen, Steven Rogers, and Byron Kemper

The terminal tail region of a yeast myosin-V 14799-14804 mediates its attachment to vacuole membranes and sites of polarized growth

Natalie L. Catlett and Lois S. Weisman

The increased level of ,31,4-galactosyltransferase 14805-14810 required for lactose biosynthesis is achieved in part by translational control

Martin Charron, Joel H. Shaper, and Nancy L. Shaper

Identification and characterization of a 14811-14815 retinoid-induced class II tumor suppressor/growth regulatory gene

Daniel DiSepio, Corine Ghosn, Richard L. Eckert, Anne Deucher, Nancy Robinson, Madeleine Duvic, Roshantha A. S. Chandraratna, and Sunil Nagpal

Phosphorylation of the rRNA transcription factor 14816-14820 upstream binding factor promotes its association with TATA binding protein

Anthony J. Kihm, James C. Hershey, Timothy A. J. Haystead, Cort S. Madsen, and Gary K. Owens

Reciprocal interactions between ,31-integrin and 14821-14826 epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology

Fei Wang, Valerie M. Weaver, Ole W. Petersen, Carolyn A. Larabell, Shoukat Dedhar, Per Briand, Ruth Lupu, and Mina J. Bissell

DEVELOPMENTAL BIOLOGY

Interference with gene regulation in living sea 14827-14832 urchin embryos: Transcription factor Knock Out (TKO), a genetically controlled vector for blockade of specific transcription factors

Leonard D. Bogarad, Maria I. Arnone, Chieh Chang, and Eric H. Davidson

Mitogen-activated protein kinase and neural 14833-14838 specification in Xenopus

Aarti R. Uzgare, J. Akif Uzman, Heithem M. El-Hodiri, and Amy K. Sater

ECOLOGY

Drought-induced shift of a forest-woodland ecotone: 14839-14842 Rapid landscape response to climate variation

Craig D. Allen and David D. Breshears

Stream biodiversity: The ghost of land use past 14843-14847 J. S. Harding, E. F. Benfield, P. V. Bolstad, G. S. Helfman, and E. B. D. Jones, III

EVOLUTION

Matchings and phylogenetic trees 14600-14602 Persi W. Diaconis and Susan P. Holmes

Tarsier-like locomotor specializations in the 14848-14850 Oligocene primate Afrotarsius

D. Tab Rasmussen, Glenn C. Conroy, and Elwyn L. Simons

Tracking molecular evolution of photosynthesis by 14851-14856 characterization of a major photosynthesis gene cluster from Heliobacillus mobilis

Jin Xiong, Kazuhito Inoue, and Carl E. Bauer

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Page 13: Front Matter

Contents

Social transmission of reproductive behavior 15140-15144 increases frequency of inherited disorders in a young-expanding population

Fr6d6ric Austerlitz and Evelyne Heyer

GENETICS

A model system to study genomic imprinting of 14857-14862 human genes

J. M. Gabriel, M. J. Higgins, T. C. Gebuhr, T. B. Shows, S. Saitoh, and R. D. Nicholls

Cluster analysis and display of genome-wide 14863-14868 expression patterns

Michael B. Eisen, Paul T. Spellman, Patrick 0. Brown, and David Botstein

Genome scan of human systemic lupus 14869-14874 erythematosus: Evidence for linkage on chromosome lq in African-American pedigrees

Kathy L. Moser, Barbara R. Neas, Jane E. Salmon, Hua Yu, Courtney Gray-McGuire, Neeraj Asundi, Gail R. Bruner, Jerome Fox, Jennifer Kelly, Stephanie Henshall, Debra Bacino, Myron Dietz, Robert Hogue, Gerald Koelsch, Lydia Nightingale, Tim Shaver, Nabih I. Abdou, Daniel A. Albert, Craig Carson, Michelle Petri, Edward L. Treadwell, Judith A. James, and John B. Harley

A genome-wide search for susceptibility genes in 14875-14879 human systemic lupus erythematosus sib-pair families

Patrick M. Gaffney, Grainne M. Kearns, Katherine B. Shark, Ward A. Ortmann, Scott A. Selby, Michelle L. Malmgren, Kristine E. Rohlf, Theresa C. Ockenden, Ronald P. Messner, Richard A. King, Stephen S. Rich, and Timothy W. Behrens

Correction of murine galactosialidosis by bone 14880-14885 marrow-derived macrophages overexpressing human protective protein/cathepsin A under control of the colony-stimulating factor-1 receptor promoter

Christopher N. Hahn, Maria del Pilar Martin, Xiao-Yan Zhou, Linda W. Mann, and Alessandra d'Azzo

Transgenic knockout mice exclusively expressing 14886-14890 human hemoglobin S after transfer of a 240-kb ,s-globin yeast artificial chromosome: A mouse model of sickle cell anemia

Judy C. Chang, Ronghua Lu, Chin Lin, Shan-Mei Xu, Yuet Wai Kan, Susanna Porcu, Elaine Carlson, Michael Kitamura, Suya Yang, Linda Flebbe-Rehwaldt, and Karin M. L. Gaensler

Gene dosage and stochastic effects determine the 14891-14896 severity and direction of uniparental ribosomal RNA gene silencing (nucleolar dominance) in Arabidopsis allopolyploids

Z. Jeffrey Chen, Luca Comai, and Craig S. Pikaard

IMMUNOLOGY

Identification of a proline-binding motif regulating 14897-14902 CD2-triggered T lymphocyte activation

Kazuhisa Nishizawa, Christian Freund, Jing Li, Gerhard Wagner, and Ellis L. Reinherz

In vivo priming of T cells against cryptic 14903-14908 determinants by dendritic cells exposed to interleukin 6 and native antigen

Hal Drakesmith, Deborah O'Neil, Susanne C. Schneider, Mike Binks, Patrick Medd, Eli Sercarz, Peter Beverley, and Benjamin Chain

Specific requirement for CD3s in T cell development 14909-14914 Jan B. DeJarnette, Connie L. Sommers, Kun Huang, Kenneth J. Woodside, Rebecca Emmons, Kenneth Katz, Elizabeth W. Shores, and Paul E. Love

Susceptibility to the biological effects of polyaromatic 14915-14919 hydrocarbons is influenced by genes of the major histocompatibility complex

Craig A. Elmets, Mohammad Athar, Karen A. Tubesing, Dinah Rothaupt, Hui Xu, and Hasan Mukhtar

Tumor cells expressing a retroviral envelope 14920-14925 escapeimmune rejection in vivo

Marianne Mangeney and Thierry Heidmann

Models of immune memory: On the role of 14926-14931 cross-reactive stimulation, competition, and homeostasis in maintaining immune memory

Rustom Antia, Sergei S. Pilyugin, and Rafi Ahmed

MEDICAL SCIENCES

WISP genes are members of the connective tissue 14717-14722 growth factor family that are up-regulated in Wnt-1-transformed cells and aberrantly expressed in human colon tumors

Diane Pennica, Todd A. Swanson, James W. Welsh, Margaret A. Roy, David A. Lawrence, James Lee, Jennifer Brush, Lisa A. Taneyhill, Bethanne Deuel, Michael Lew, Colin Watanabe, Robert L. Cohen, Mona F. Melhem, Gene G. Finley, Phil Quirke, Audrey D. Goddard, Kenneth J. Hillan, Austin L. Gurney, David Botstein, and Arnold J. Levine

Improved cervical smear assessment using antibodies 14932-14937 against proteins that regulate DNA replication

Gareth H. Williams, Piotr Romanowski, Lesley Morris, Mark Madine, Anthony D. Mills, Kai Stoeber, Jackie Marr, Ronald A. Laskey, and Nicholas Coleman

Organization of the human myostatin gene and 14938-14943 expression in healthy men and HIV-infected men with muscle wasting

Nestor F. Gonzalez-Cadavid, Wayne E. Taylor, Kevin Yarasheski, Indrani Sinha-Hikim, Kun Ma, Shereen Ezzat, Ruoqing Shen, Rukhsana Lalani, Sylvia Asa, Mohamad Mamita, Gouri Nair, Stefan Arver, and Shalender Bhasin

Mature monocytic cells enter tissues and engraft 14944-14949 David W. Kennedy and Janis L. Abkowitz

The Akt kinase: Molecular determinants 14950-14955 of oncogenicity

Masahiro Aoki, Osvaldo Batista, Alfonso Bellacosa, Philip Tsichlis, and Peter K. Vogt

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Contents Evidence for a genetic basis for hyperandrogenemia 14956-14960 in polycystic ovary syndrome

Richard S. Legro, Deborah Driscoll, Jerome F. Strauss, III, Janis Fox, and Andrea Dunaif

Production of ,B-defensins by human airway epithelia 14961-14966 Pradeep K. Singh, Hong Peng Jia, Kerry Wiles, Jay Hesselberth, Lide Liu, Barbara-Ann D. Conway, Everett P. Greenberg, Erika V. Valore, Michael J. Welsh, Tomas Ganz, Brian F. Tack, and Paul B. McCray, Jr.

MICROBIOLOGY

Phenotypic switching in the human pathogenic 14967-14972 fungus Cryptococcus neoformans is associated with changes in virulence and pulmonary inflammatory response in rodents

David L. Goldman, Bettina C. Fries, Sarah P. Franzot, Lya Montella, and Arturo Casadevall

Suppression of an absolute defect in Type IV pilus 14973-14978 biogenesis by loss-of-function mutations in pilT, a twitching motility gene in Neisseria gonorrhoeae

Matthew Wolfgang, Hae-Sun Park, Stanley F. Hayes, Jos P. M. van Putten, and Michael Koomey

Bacteroides fragilis enterotoxin cleaves the zonula 14979-14984 adherens protein, E-cadherin

Shaoguang Wu, Kuei-Cheng Lim, Julie Huang, Roxan F. Saidi, and Cynthia L. Sears

Isolation and characterization of iron-independent 14985-14990 positive dominant mutants of the diphtheria toxin repressor DtxR

Li Sun, Johanna vanderSpek, and John R. Murphy

NEUROBIOLOGY

Human y-aminobutyric acid type B receptors are 14991-14996 differentially expressed and regulate inwardly rectifying K+ channels

Klemens Kaupmann, Valerie Schuler, Johannes Mosbacher, Serge Bischoff, Helmut Bittiger, Jakob Heid, Wolfgang Froestl, Sabine Leonhard, Torsten Pfaff, Andreas Karschin, and Bernhard Bettler

Nerve growth factor acutely reduces chemical 14997-15002 transmission by means of postsynaptic TrkA-like receptors in squid giant synapse

Herman Moreno, Marcela Nadal, Elena Leznik, Mutsuyuki Sugimori, Irit Lax, Joseph Schlessinger, and Rodolfo Llinas

Basolateral amygdala is not critical for cognitive 15003-15007 memory of contextual fear conditioning

Almira Vazdarjanova and James L. McGaugh

Memory fields of neurons in the primate 15008-15013 prefrontal cortex

Gregor Rainer, Wael F. Asaad, and Earl K. Miller

Phosphorylation of photolyzed rhodopsin is 15014-15019 calcium-insensitive in retina permeabilized by a-toxin

Annie E. Otto-Bruc, Robert N. Fariss, J. Preston Van Hooser, and Krzysztof Palczewski

Rolipram, a type IV-specific phosphodiesterase 15020-15025 inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory

Mark Barad, Roussoudan Bourtchouladze, Danny G. Winder, Hava Golan, and Eric Kandel

Perturbed dentate gyrus function in serotonin 15026-15031 5-HT2C receptor mutant mice

Laurence H. Tecott, Sheree F. Logue, Jeanne M. Wehner, and Julie A. Kauer

Patches of synchronized activity in the cerebellar 15032-15036 cortex evoked by mossy-fiber stimulation: Questioning the role of parallel fibers

Dana Cohen and Yosef Yarom

Memory and long-term potentiation (LTP) 15037-15042 dissociated: Normal spatial memory despite CAl LTP elimination with Kv1.4 antisense

Noam Meiri, Miao-Kun Sun, Zachary Segal, and Daniel L. Alkon

The neuropeptide Y/agouti gene-related protein 15043-15048 (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice

Christian Broberger, Jeanette Johansen, Carolina Johansson, Martin Schalling, and Tomas Hokfelt

Elevated anxiety and antidepressant-like responses 15049-15054 in serotonin 5-HT1A receptor mutant mice

Lora K. Heisler, Hung-Ming Chu, Thomas J. Brennan, Jean A. Danao, Preetpaul Bajwa, Loren H. Parsons, and Laurence H. Tecott

Specific intercellular binding of the ,B-amyloid 15055-15060 precursor protein to the presenilins induces intercellular signaling: Its significance for Alzheimer's disease

Nazneen N. Dewji and S. J. Singer

Activation of human primary motor cortex during 15061-15065 action observation: A neuromagnetic study

R. Hari, N. Forss, S. Avikainen, E. Kirveskari, S. Salenius, and G. Rizzolatti

Altered ratios of alternatively spliced long and short 15066-15071 y2 subunit mRNAs of the y-amino butyrate type A receptor in prefrontal cortex of schizophrenics

Molly M. Huntsman, Bich-Van Tran, Stephen G. Potkin, William E. Bunney, Jr., and Edward G. Jones

Early physiological abnormalities after simian 15072-15077 immunodeficiency virus infection

Thomas F. W. Horn, Salvador Huitron-Resendiz, Michael R. Weed, Steven J. Henriksen, and Howard S. Fox

Metabotropic glutamate receptor-initiated 15078-15083 translocation of protein kinase p9orsk to polyribosomes: A possible factor regulating synaptic protein synthesis

Frank Angenstein, William T. Greenough, and Ivan Jeanne Weiler

PHARMACOLOGY

Identity of adenylyl cyclase isoform determines the 15084-15089 rate of cell cycle progression in NIH 3T3 cells

Martine J. Smit, Dennis Verzijl, and Ravi Iyengar

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Contents

PHYSIOLOGY

Impaired metabolic modulation of a-adrenergic 15090-15095 vasoconstriction in dystrophin-deficient skeletal muscle

Gail D. Thomas, Mikael Sander, Kim S. Lau, Paul L. Huang, James T. Stull, and Ronald G. Victor * See Commentary on page 14592

Termination of Ca2+ release by a local inactivation 15096-15101 of ryanodine receptors in cardiac myocytes

James S. K. Sham, Long-Sheng Song, Ye Chen, Li-Hua Deng, Michael D. Stern, Edward G. Lakatta, and Heping Cheng

PLANT BIOLOGY

In situ synthesis of 3-glucan microfibrils on tobacco 15102-15106 plasma membrane sheets

Noriko Hirai, Seiji Sonobe, and Takahisa Hayashi

Separate jasmonate-dependent and 15107-15111 salicylate-dependent defense-response pathways in Arabidopsis are essential for resistance to distinct microbial pathogens

Bart P. H. J. Thomma, Kristel Eggermont, Iris A. M. A. Penninckx, Brigitte Mauch-Mani, Ralph Vogelsang, Bruno P. A. Cammue, and Willem F. Broekaert

The Arabidopsis thaliana AGRAVITROPIC I gene 15112-15117 encodes a component of the polar-auxin-transport efflux carrier

Rujin Chen, Pierre Hilson, John Sedbrook, Elizabeth Rosen, Timothy Caspar, and Patrick H. Masson

A homeobox gene with potential developmental 15118-15122 control function in the meristem of the conifer Picea abies

A. Sund'as-Larsson, M. Svenson, H. Liao, and P. Engstrom

Carbohydrate binding and resistance to proteolysis 15123-15128 control insecticidal activity of Griffonia simplicifolia lectin II

Keyan Zhu-Salzman, Richard E. Shade, Hisashi Koiwa, Ron A. Salzman, Meena Narasimhan, Ray A. Bressan, Paul M. Hasegawa, and Larry L. Murdock

Roles for mannitol and mannitol dehydrogenase 15129-15133 in active oxygen-mediated plant defense

Dianne B. Jennings, Marilyn Ehrenshaft, D. Mason Pharr, and John D. Williamson

The Arabidopsis CHL1 protein plays a major role 15134-15139 in high-affinity nitrate uptake

Rongchen Wang, Dong Liu, and Nigel M. Crawford

Social Sciences

ANTHROPOLOGY

Social transmission of reproductive behavior 15140-15144 increases frequency of inherited disorders in a young-expanding population

Fr6d6ric Austerlitz and Evelyne Heyer

Patterns of prehistoric human mobility in Polynesia 15145-15150 indicated by mtDNA from the Pacific rat

E. Matisoo-Smith, R. M. Roberts, G. J. Irwin, J. S. Allen, D. Penny, and D. M. Lambert

PSYCHOLOGY

Memory fields of neurons in the primate 15008-15013 prefrontal cortex

Gregor Rainer, Wael F. Asaad, and Earl K. Miller

CORRECTION

DEVELOPMENTAL BIOLOGY Endothelin-induced conversion of embryonic heart 15151 muscle cells into impulse-conducting Purkinje fibers

Robert G. Gourdie, Yan Wei, Darlene Kim, Sandra C. Klatt, and Takashi Mikawa

AUTHOR INDEX xiii-xv

INFORMATION FOR AUTHORS xvi-xviii

SIZING WORKSHEET xix

DOCUMENTATION REPORT xx

COPYRIGHT ASSIGNMENT FORM xxi

SUBSCRIPTION FORM xxii

CLASSIFIED ADVERTISEMENTS xxiii-xxiv

Cover photograph: Bronze embossed doors at the entrance to the National Academy of Sciences depicting major figures in science. This section features Galileo, Newton, Lyell, Darwin, Watt, and Pasteur. Created by Lee Lawrie (1923).

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