Front Matter Source: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, No. 5 (Mar. 2, 1999), pp. i-x Published by: National Academy of Sciences Stable URL: http://www.jstor.org/stable/46966 . Accessed: 06/05/2014 00:18 Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at . http://www.jstor.org/page/info/about/policies/terms.jsp . JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact [email protected]. . National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access to Proceedings of the National Academy of Sciences of the United States of America. http://www.jstor.org This content downloaded from 130.132.123.28 on Tue, 6 May 2014 00:18:30 AM All use subject to JSTOR Terms and Conditions
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Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 96, No. 5 (Mar. 2, 1999), pp. i-xPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/46966 .
Accessed: 06/05/2014 00:18
Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at .http://www.jstor.org/page/info/about/policies/terms.jsp
.JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range ofcontent in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new formsof scholarship. For more information about JSTOR, please contact [email protected].
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PNAS Proceedings of the National Academy of Sciences of the United States of America
March 2, 1999 j vol. 96 no. 5 pp. 1811-2570 www.pnas.org
p:- 0~
Complete exchange of rRNA genes between bacteria Deafness dystonia syndrome is a mitochondrial disease Extinctions on a large Melanesian island Osmosensory transcription factor Potential new treatment for phenylketonuria
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Overexpression of the Bacillus thuringiensis (Bt) 1840-1845 Cry2Aa2 protein in chloroplasts confers resistance to plants against susceptible and Bt-resistant insects
Madhuri Kota, Henry Daniell, Sam Varma, Stephen F. Garczynski, Fred Gould, and William J. Moar
APPLIED BIOLOGICAL SCIENCES
Multiple genetic modifications of the erythromycin 1846-1851 polyketide synthase to produce a library of novel "unnatural" natural products
Robert McDaniel, Arinthip Thamchaipenet, Claes Gustafsson, Hong Fu, Melanie Betlach, Mary Betlach, and Gary Ashley
BIOCHEMISTRY
Unexpected crucial role of residue 225 in 1852-1857 serine proteases
Enriqueta R. Guinto, Sonia Caccia, Thierry Rose, Klaus Fiitterer, Gabriel Waksman, and Enrico Di Cera
Proteasome-dependent degradation of the human 1858-1862 estrogen receptor
Zafar Nawaz, David M. Lonard, Andrew P. Dennis, Carolyn L. Smith, and Bert W. O'Malley
Structure of a cytochrome P450-redox partner 1863-1868 electron-transfer complex
Irina F. Sevrioukova, Huiying Li, Hong Zhang, Julian A. Peterson, and Thomas L. Poulos
Studies on the interactions between human replication 1869-1874 factor C and human proliferating cell nuclear antigen
Gang Zhang, Emma Gibbs, Zvi Kelman, Michael O'Donnell, and Jerard Hurwitz
p53-induced DNA bending and twisting: p53 1875-1880 tetramer binds on the outer side of a DNA loop and increases DNA twisting
Akhilesh K. Nagaich, Victor B. Zhurkin, Stewart R. Durell, Robert L. Jernigan, Ettore Appella, and Rodney E. Harrington
Interaction of 5-lipoxygenase with cellular proteins 1881-1,885 Patrick Provost, Bengt Samuelsson, and Olof Radmark
tRNAV1-heterodimeric maxizymes with high potential 1886-1891 as gene-inactivating agents: Simultaneous cleavage at two sites in HIV-1 tat mRNA in cultured cells
Tomoko Kuwabara, Masaki Warashina, Aya Nakayama, Jun Ohkawa, and Kazunari Taira
Fibroblast growth factors 1 and 2 are distinct in 1892-1897 oligomerization in the presence of heparin-like glycosaminoglycans
Ganesh Venkataraman, Zachary Shriver, Joseph C. Davis, and Ram Sasisekharan
Small antibody-like proteins with prescribed ligand 1898-1903 specificities derived from the lipocalin fold
Gerald Beste, Frank S. Schmidt, Thomas Stibora, and Arne Skerra
Angiopoietins 3 and 4: Diverging gene counterparts 1904-1909 in mice and humans
David M. Valenzuela, Jennifer A. Griffiths, Jose Rojas, Thomas H. Aldrich, Pamela F. Jones, Hao Zhou, Joyce McClain, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Tammy Huang, Nick Papadopoulos, Peter C. Maisonpierre, Samuel Davis, and George D. Yancopoulos
Selenium redox biochemistry of zinc-sulfur 1910-1914 coordination sites in proteins and enzymes
Claus Jacob, Wolfgang Maret, and Bert L. Vallee
Native display of complete foreign protein domains 1915-1920 on the surface of hepatitis B virus capsids
Peter A. Kratz, Bettina B13ttcher, and Michael Nassal
Nuclear foci of mammalian recombination proteins 1921-1926 are located at single-stranded DNA regions formed after DNA damage
Elke Raderschall, Efim I. Golub, and Thomas Haaf
Structure and function in rhodopsin: Kinetic studies 1927-1931 of retinal binding to purified opsin mutants in defined phospholipid-detergent mixtures serve as probes of the retinal binding pocket
Philip J. Reeves, John Hwa, and H. Gobind Khorana
Structure and function in rhodopsin: Further 1932-1935 elucidation of the role of the intradiscal cysteines, Cys-110, -185, and -187, in rhodopsin folding and function
John Hwa, Philip J. Reeves, Judith Klein-Seetharaman, Florence Davidson, and H. Gobind Khorana
Inhibitory sites in enzymes: Zinc removal and 1936-1940 reactivation by thionein
Wolfgang Maret, Claus Jacob, Bert L. Vallee, and Edmond H. Fischer
Mg-chelatase of tobacco: The role of the subunit 1941-1.946 CHL D in the chelation step of protoporphyrin IX
Susanna Grafe, Hans-Peter Saluz, Bernhard Grimm, and Frank Hanel
The GTPase activating factor for transducin in rod 1947-1952 photoreceptors is the complex between RGS9 and type 5 G protein / subunit
Elina R. Makino, Jason W. Handy, Tiansen Li, and Vadim Y. Arshavsky
Affinity modulation of small-molecule ligands by 1953-1958 borrowing endogenous protein surfaces
Roger Briesewitz, Gregory T. Ray, Thomas J. Wandless, and Gerald R. Crabtree V See Commentary on page 1826
iv
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Contents Thyroid hormone receptor-associated proteins and 1959-1964 general positive cofactors mediate thyroid hormone receptor function in the absence of the TATA box-binding protein-associated factors of TFIID
Joseph D. Fondell, Mohamed Guermah, Sohail Malik, and Robert G. Roeder
The crayfish plasma clotting protein: A 1965-1970 vitellogenin-related protein responsible for clot formation in crustacean blood
Martin Hall, Ruigong Wang, Rik van Antwerpen, Lars Sottrup-Jensen, and Kenneth Soderhall
An Escherichia coli strain with all chromosomal 1971-1976 rRNA operons inactivated: Complete exchange of rRNA genes between bacteria
Tsuneaki Asai, Dmitry Zaporojets, Craig Squires, and Catherine L. Squires i See Commentary on page 1820
Cytochrome P450 CYPIBI determines susceptibility 1977-1982 to 7,12-dimethylbenz[a]anthracene-induced lymphomas
Jeroen T. M. Buters, Shuichi Sakai, Thomas Richter, Thierry Pineau, David L. Alexander, Uzen Savas, Johannes Doehmer, Jerrold M. Ward, Colin R. Jefcoate, and Frank J. Gonzalez
Tolerance of Arc repressor to 1983-1988 multiple-alanine substitutions
Bronwen M. Brown and Robert T. Sauer
Direct interaction of lignin and lignin peroxidase 1989-1994 from Phanerochaete chrysosporium
Toru Johjima, Noriyuki Itoh, Mari Kabuto, Fusayo Tokimura, Tamon Nakagawa, Hiroyuki Wariishi, and Hiroo Tanaka
Ligand-dependent activation of transcription in vitro 1995-2000 by retinoic acid receptor a/retinoid X receptor a heterodimers that mimics transactivation by retinoids in vivo
F. Jeffrey Dilworth, Catherine Fromental-Ramain, Eumorphia Remboutsika, Arndt Benecke, and Pierre Chambon
The vacuolating toxin from Helicobacter pylori forms 2001-2006 hexameric pores in lipid bilayers at low pH
Daniel M. Czajkowsky, Hideki Iwamoto, Timothy L. Cover, and Zhifeng Shao
Specificity of native-like interhelical hydrophobic 2007-2012 contacts in the apomyoglobin intermediate
Michael S. Kay, Carlos H. I. Ramos, and Robert L. Baldwin
Cryptocyanin, a crustacean molting protein: 2013--2018 Evolutionary link with arthropod hemocyanins and insect hexamerins
Nora B. Terwilliger, Lawrence Dangott, and Margaret Ryan
BIOPHYSICS
A specific transition state for S-peptide combining 2019-2024 with folded S-protein and then refolding
Jonathan M. Goldberg and Robert L. Baldwin
Energy-based de novo protein folding by 2025-2030 conformational space annealing and an off-lattice united-residue force field: Application to the 10-55 fragment of staphylococcal protein A and to apo calbindin D9K
Jooyoung Lee, Adam Liwo, and Harold A. Scheraga
Stretching lattice models of protein folding 2031-2035 Nicholas D. Socci, Jos6 Nelson Onuchic, and Peter G. Wolynes
The two-dimensional IR nonlinear spectroscopy of 2036-2041 a cyclic penta-peptide in relation to its three-dimensional structure
Peter Hamm, Manho Lim, William F. DeGrado, and Robin M. Hochstrasser
Copper binding to the prion protein: Structural 2042-2047 implications of four identical cooperative binding sites
John H. Viles, Fred E. Cohen, Stanley B. Prusiner, David B. Goodin, Peter E. Wright, and H. Jane Dyson
Protrusive growth from giant liposomes driven by 2048-2053 actin polymerization
Hidetake Miyata, Shuji Nishiyama, Ken-ichirou Akashi, and Kazuhiko Kinosita, Jr.
Multiple pathways for ultrafast transduction of light 2054-2059 energy in the photosynthetic reaction center of Rhodobacter sphaeroides
Marion E. van Brederode, Frank van Mourik, Ivo H. M. van Stokkum, Michael R. Jones, and Rienk van Grondelle
CELL BIOLOGY
Mouse trp2, the homologue of the human trpc2 2060-2064 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca2+ entry channel
Brigitte Vannier, Michael Peyton, Gulain Boulay, Darren Brown, Ning Qin, Meisheng Jiang, Xi Zhu, and Lutz Birnbaumer
Tumor suppression in human skin carcinoma cells 2065-2070 by chromosome 15 transfer or thrombospondin-1 overexpression through halted tumor vascularization
Kerstin Bleuel, Susanne Popp, Norbert E. Fusenig, Eric J. Stanbridge, and Petra Boukamp
The conserved SOCS box motif in suppressors of 2071-2076 cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
Jian-Guo Zhang, Alison Farley, Sandra E. Nicholson, Tracy A. Willson, Lisa M. Zugaro, Richard J. Simpson, Robert L. Moritz, Dale Cary, Rachael Richardson, George Hausmann, Benjamin J. Kile, Stephen B. H. Kent, Warren S. Alexander, Donald Metcalf, Douglas J. Hilton, Nicos A. Nicola, and Manuel Baca
Myogenic signaling of phosphatidylinositol 3-kinase 2077-2081 requires the serine-threonine kinase Akt/protein kinase B
Bing-Hua Jiang, Masahiro Aoki, Jenny Z. Zheng, Jian Li, and Peter K. Vogt
Interferon-induced human MxA GTPase blocks 2082-2086 nuclear import of Thogoto virus nucleocapsids
Georg Kochs and Otto Haller
v
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Immunophilins, Refsum disease, and lupus nephritis: 2104-2109 The peroxisomal enzyme phytanoyl-COA a-hydroxylase is a new FKBP-associated protein
B6atrice Chambraud, Christine Radanyi, Jacques H. Camonis, Krzysztof Rajkowski, Michael Schumacher, and Etienne-Emile Baulieu
Regulation of GI progression by the PTEN tumor 2110-2115 suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway
Shivapriya Ramaswamy, Noriaki Nakamura, Francisca Vazquez, David B. Batt, Sauni Perera, Thomas M. Roberts, and William R. Sellers
Human PEX19: cDNA cloning by functional 2116-2121 complementation, mutation analysis in a patient with Zeliweger syndrome, and potential role in peroxisomal membrane assembly
Yuji Matsuzono, Naohiko Kinoshita, Shigehiko Tamura, Nobuyuki Shimozawa, Maho Hamasaki, Kamran Ghaedi, Ronald J. A. Wanders, Yasuyuki Suzuki, Naomi Kondo, and Yukio Fujiki
The small GTPase RalA targets filamin to 2122-2128 induce filopodia
Yasutaka Ohta, Nobuchika Suzuki, Shun Nakamura, John H. Hartwig, and Thomas P. Stossel
The RD114/simian type D retrovirus receptor is a 2129-2134 neutral amino acid transporter
John E. J. Rasko, Jean-Luc Battini, Rebecca J. Gottschalk, Ilya Mazo, and A. Dusty Miller
Dynamic and quantitative Ca2+ measurements using 2135-2140 improved cameleons
Atsushi Miyawaki, Oliver Griesbeck, Roger Heim, and Roger Y. Tsien
Human deafness dystonia syndrome is a 2141-2146 mitochondrial disease
Carla M. Koehler, Danielle Leuenberger, Sabeeha Merchant, Anja Renold, Tina Junne, and Gottfried Schatz * See Commentary on page 1817
pS3 regulates a G2 checkpoint through cyclin Bi 2147-2152 Steven A. Innocente, John L. A. Abrahamson, John P. Cogswell, and Jonathan M. Lee
Dynamics and elasticity of the fibronectin matrix in 2153-2158 living cell culture visualized by fibronectin-green fluorescent protein
Tomoo Ohashi, Daniel P. Kiehart, and Harold P. Erickson
DEVELOPMENTAL BIOLOGY
In vitro hematopoietic and endothelial potential of 2159-2164 flk-1-/- embryonic stem cells and embryos
Andre C. Schuh, Patrick Faloon, Qing-Long Hu, Munsif Bhimani, and Kyunghee Choi
Conservation of the expression and function of 2165-2170 apterous orthologs in Drosophila and mammals
Diego E. Rinc6n-Limas, Cheng-Hsin Lu, Inmaculada Canal, Manuel Calleja, Concepci6n Rodriguez-Esteban, Juan Carlos Izpisua-Belmonte, and Juan Botas
EVOLUTION
Spontaneous heterosis in larval life-history traits of 2171-2176 hemiclonal frog hybrids
Hansjuirg Hotz, Raymond D. Semlitsch, Eva Gutmann, Gaston-Denis Guex, and Peter Beerli
Molecular studies suggest that cartilaginous fishes 2177-2182 have a terminal position in the piscine tree
Ann-Sofie Rasmussen and Ulfur Arnason
Expression of a Hox gene, Cnox-2, and the division 2183-2186 of labor in a colonial hydroid
Paulyn Cartwright, Julia Bowsher, and Leo W. Buss
Coalescent estimates of HIV-1 generation time in vivo 2187-2191 Allen G. Rodrigo, Eugene G. Shpaer, Eric L. Delwart, Astrid K. N. Iversen, Michael V. Gallo, Jurgen Brojatsch, Martin S. Hirsch, Bruce D. Walker, and James I. Mullins
Evolutionary relationships among diverse 2192-2197 bacteriophages and prophages: All the world's a phage
Roger W. Hendrix, Margaret C. M. Smith, R. Neil Burns, Michael E. Ford, and Graham F. Hatfull
Prehistoric birds from New Ireland, Papua New 2563-2568 Guinea: Extinctions on a large Melanesian island
David W. Steadman, J. Peter White, and Jim Allen
GENETICS
Type 2 diabetes: Evidence for linkage on chromosome 2198-2203 20 in 716 Finnish affected sib pairs
Soumitra Ghosh, Richard M. Watanabe, Elizabeth R. Hauser, Timo Valle, Victoria L. Magnuson, Michael R. Erdos, Carl D. Langefeld, James Balow, Jr., Delphine S. Ally, Kimmo Kohtamaki, Peter Chines, Gunther Birznieks, Hong-Shi Kaleta, Anjene Musick, Catherine Te, Joyce Tannenbaum, William Eldridge, Shane Shapiro, Colin Martin, Alyson Witt, Alistair So, Jennie Chang, Ben Shurtleff, Rachel Porter, Kristina Kudelko, Arun Unni, Leonid Segal, Ravi Sharaf, Jillian Blaschak-Harvan, Johan Eriksson, Tuula Tenkula, Gabriele Vidgren, Christian Ehnholm, Eva Tuomilehto-Wolf, William Hagopian, Thomas A. Buchanan, Jaakko Tuomilehto, Richard N. Bergman, Francis S. Collins, and Michael Boehnke
vi
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Yeast and human genes that affect the Escherichia 2204-2209 coli SOS response
Edward L. Perkins, Joan F. Sterling, Vera I. Hashem, and Michael A. Resnick
Localization of non-Mhc collagen-induced arthritis 2210-2214 susceptibility loci in DBA/lj mice
Richard A. Mclndoe, Beverly Bohlman, Emil Chi, Eugene Schuster, Molly Lindhardt, and Leroy Hood
IMMUNOLOGY
Conformational changes in tertiary structure near the 2215-2220 ligand binding site of an integrin I domain
Claus Oxvig, Chafen Lu, and Timothy A. Springer
In situ detection of activated Bruton's tyrosine kinase 2221-2226 in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies
Sazuku Nisitani, Roberta M. Kato, David J. Rawlings, Owen N. Witte, and Matthew I. Wahl
Terreic acid, a quinone epoxide inhibitor of Bruton's 2227-2232 tyrosine kinase
Yuko Kawakami, Stephen E. Hartman, Eiji Kinoshita, Hidefumi Suzuki, Jiro Kitaura, Libo Yao, Naoki Inagaki, Alessandra Franco, Daisuke Hata, Mari Maeda-Yamamoto, Hiromi Fukamachi, Hiroichi Nagai, and Toshiaki Kawakami
Immune surveillance against a solid tumor fails 2233-2238 because of immunological ignorance
Adrian F. Ochsenbein, Paul Klenerman, Urs Karrer, Burkhard Ludewig, Marcus Pericin, Hans Hengartner, and Rolf M. Zinkernagel
Induction of Ig light chain gene rearrangement in 2239-2243 heavy chain-deficient B cells by activated Ras
Albert C. Shaw, Wojciech Swat, Laurie Davidson, and Frederick W. Alt
Efficient IgG-mediated suppression of primary 2244-2249 antibody responses in Fcy receptor-deficient mice
Mikael C. I. Karlsson, Sara Wernersson, Teresita Diaz de Stahl, Susanne Gustavsson, and Birgitta Heyman
Innate and acquired humoral immunities to influenza 2250-2255 virus are mediated by distinct arms of the immune system
Nicole Baumgarth, Ometa C. Herman, Gina C. Jager, Lorena Brown, Leonard A. Herzenberg, and Leonore A. Herzenberg
Gene expression, synthesis, and secretion of 2256-2261 interleukin 18 and interleukin 1f3 are differentially regulated in human blood mononuclear cells and mouse spleen cells
Adrian J. Puren, Giamila Fantuzzi, and Charles A. Dinarello
Predominant VH genes expressed in innate antibodies 2262-2267 are associated with distinctive antigen-binding sites
Katherine J. Seidl, Jennifer A. Wilshire, John D. MacKenzie, Aaron B. Kantor, Leonard A. Herzenberg, and Leonore A. Herzenberg
Systemic administration of interleukin 2 enhances 2268-2273 the therapeutic efficacy of dendritic cell-based tumor vaccines
K. Shimizu, R. C. Fields, M. Giedlin, and J. J. Mul6
Robert C. Alaniz, Steven A. Thomas, Mercedes Perez-Melgosa, Kai Mueller, Andrew G. Farr, Richard D. Palmiter, and Christopher B. Wilson
Crossreactive recognition of viral, self, and bacterial 2279-2284 peptide ligands by human class I-restricted cytotoxic T lymphocyte clonotypes: Implications for molecular mimicry in autoimmune disease
Ihor S. Misko, Simone M. Cross, Rajiv Khanna, Suzanne L. Elliott, Christopher Schmidt, Stephanie J. Pye, and Sharon L. Silins
Activation of target-tissue immune-recognition 2285-2290 molecules by double-stranded polynucleotides
Koichi Suzuki, Atsumi Mori, Ken J. Ishii, Jun Saito, Dinah S. Singer, Dennis M. Klinman, Philip R. Krause, and Leonard D. Kohn
MEDICAL SCIENCES
In vivo analysis of the 3' untranslated region of the 2291-2295 hepatitis C virus after in vitro mutagenesis of an infectious cDNA clone
Masayuki Yanagi, Marisa St. Claire, Suzanne U. Emerson, Robert H. Purcell, and Jens Bukh
Neonatal gene transfer leads to widespread 2296-2300 correction of pathology in a murine model of lysosomal storage disease
Thomas M. Daly, Carole Vogler, Beth Levy, Mark E. Haskins, and Mark S. Sands
Mutations in the nebulin gene associated with 2305-2310 autosomal recessive nemaline myopathy
Katarina Pelin, Pirta Hilpela, Kati Donner, Caroline Sewry, Patrick A. Akkari, Stephen D. Wilton, Duangrurdee Wattanasirichaigoon, Marie-Louise Bang, Thomas Centner, Folker Hanefeld, Sylvie Odent, Michel Fardeau, J. Andoni Urtizberea, Francesco Muntoni, Victor Dubowitz, Alan H. Beggs, Nigel G. Laing, Siegfried Labeit, Albert de la Chapelle, and Carina Wallgren-Pettersson
Blood-borne tissue factor: Another view of thrombosis 2311-2315 Peter L. A. Giesen, Ursula Rauch, Bernd Bohrmann, Dorothee Kling, Merce Roque, John T. Fallon, Juan J. Badimon, Jacques Himber, Markus A. Riederer, and Yale Nemerson
Vii
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Mutated epithelial cadherin is associated with 23 16-2321 increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells
J. A. Efstathiou, D. Liu, J. M. D. Wlheeler, H. C. Kim, N. E. Beck, M. Ilyas, A. J. Karayiannakis, N. J. McC. Mortensen, W. Kmiot, R. J. Playford, M. Pignatelli, and W. F. Bodmer
Analysis of masked mutations in familial 2322-2326 adenomatous polyposis
Steven J. Laken, Nickolas Papadopoulos, Gloria M. Petersen, Stephen B. Gruber, Stanley R. Hamilton, Francis M. Giardiello, Jill D. Brensinger, Bert Vogelstein, and Kenneth W. Kinzler
Regulation of fatty acid homeostasis in cells: Novel 2327-2332 role of leptin
Roger H. Unger, Yan-Ting Zhou, and Lelio Orci
Imaging adenoviral-directed reporter gene expression 2333-2338 in living animals with positron emission tomography
Sanjiv S. Gambhir, Jorge R. Barrio, Michael E. Phelps, Meera Iyer, Mohammad Namavari, Nagichettiar Satyamurthy, Lily Wu, Leeta A. Green, Eileen Bauer, Duncan C. MacLaren, Khoi Nguyen, Arnold J. Berk, Simon R. Cherry, and Harvey R. Herschman
A different approach to treatment of phenylketonuria: 2339-2344 Phenylalanine degradation with recombinant phenylalanine ammonia lyase
Christineh N. Sarkissian, Zhongqi Shao, Frangoise Blain, Rosalie Peevers, Hongsheng Su, Robert Heft, Thomas M. S. Chang, and Charles R. Scriver * See Commentary on page 1811
Blockade of type a transforming growth factor 2345-2349 signaling prevents liver fibrosis and dysfunction in the rat
Ex vivo evaluation of a Taylor-Couette flow, 2350-2355 immobilized heparinase I device for clinical application
Guillermo A. Ameer, Gilda Barabino, Ram Sasisekharan, William Harmon, Charles L. Cooney, and Robert Langer
Mutations in the organic cation/carnitine transporter 2356-2360 OCTN2 in primary carnitine deficiency
Yuhuan Wang, Jing Ye, Vadivel Ganapathy, and Nicola Longo
Gonadotropin-releasing hormone analogue conjugates 2361-2366 with strong selective antitumor activity
I. Palyi, B. Vincze, S. Lovas, I. Mezo, J. Pat6, A. Kalnay, G. Turi, D. Gaal, R. Mihalik, I. Peter, I. Teplan, and R. F. Murphy
Interferon y expressed hy a recomhinant respiratory 2367-2372 syncytial virus attenuates virus replication in mice without compromising immunogenicity
Alexander Bukreyev, Stephen S. Whitehead, Natalya Bukreyeva, Brian R. Murphy, and Peter L. Collins
Induction of autoantibodies to mouse CCR5 with 2373-2378 riecombinant papillomavirus particles
Bryce Chackerian, Douglas R. Lowy, and John T. Schiller
Streptavidin facilitates internalization and pulmonary 2379-2384 targeting of an anti-endothelial cell antibody (platelet-endothelial cell adhesion molecule 1): A strategy for vascular immunotargeting of drugs
Vladimir R. Muzykantov, Melpo Christofidou-Solomidou, Irina Balyasnikova, David W. Harshaw, Linda Schultz, Aron B. Fisher, and Steven M. Albelda
Inhibition of advanced glycation endproduct 2385-2390 formation by acetaldehyde: Role in the cardioprotective effect of ethanol
Yousef Al-Abed, Tomoko Mitsuhashi, Hongwei Li, John A. Lawson, Garret A. FitzGerald, Hank Founds, Thomas Donnelly, Anthony Cerami, Peter Ulrich, and Richard Bucala
Reversing adipocyte differentiation: Implications for 2391-2395 treatment of obesity
Yan-Ting Zhou, Zhuo-Wei Wang, Moritake Higa, Christopher B. Newgard, and Roger H. Unger
MICROBIOLOGY
The Scalnmonella invasin SipB induces macrophage 2396-2401 apoptosis by binding to caspase-1
David Hersh, Denise M. Monack, Mark R. Smith, Nafisa Ghori, Stanley Falkow, and Arturo Zychlinsky
Continuous axenic cultivation of Pneumocystis carinii 2402-2407 Salim Merali, Ute Frevert, Jonathan H. Williams, Kevin Chin, Richard Bryan, and Allen B. Clarkson, Jr.
Pseudconionas aerutginosa killing of Caenorhabditis 2408-2413 elegans used to identify P. aerutginosa virulence factors
Man-Wah Tan, Laurence G. Rahme, Jeffrey A. Sternberg, Ronald G. Tompkins, and Frederick M. Ausubel
NEUROBIOLOGY
Preferential Zn2+ influx through Ca2+-permeable 2414-2419 AMPA/kainate channels triggers prolonged mitochondrial superoxide production
Stefano L. Sensi, Hong Z. Yin, Sean G. Carriedo, Shyam S. Rao, and John H. Weiss
A binding site for homeodomain and Pax proteins is 2420-2425 necessary for LI cell adhesion molecule gene expression by Pax-6 and bone morphogenetic proteins
Robyn Meech, Pekka Kallunki, Gerald M. Edelman, and Frederick S. Jones
The biological clock of very premature primate infants 2426-2429 is responsive to light
Haiping Hao and Scott A. Rivkees
Retinotopic mapping of lateral geniculate nucleus in 2430-2434 humans using functional magnetic resonance imaging
Wei Chen, Xiao-Hong Zhu, Keith R. Thulborn, and Kamil Ugurbil
vi.i.
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Mako Narisawa-Saito, Alcino J. Silva, Tsuyoshi Yamaguchi, Takashi Hayashi, Tadashi Yamamoto, and Hiroyuki Nawa
Molecular identification of human G-substrate, a 2467-2472 possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cells
Shogo Endo, Masako Suzuki, Mariko Sumi, Angus C. Nairn, Ryoji Morita, Kazuhiro Yamakawa, Paul Greengard, and Masao Ito
Autoinhibition of serotonin cells: An intrinsic 2473-2478 regulatory mechanism sensitive to the pattern of usage of the cells
Ralf Heinrich, Stuart I. Cromarty, Michael Horner, Donald H. Edwards, and Edward A. Kravitz
A neomorphic syntaxin mutation blocks 2479-2484 volatile-anesthetic action in Caenorhabditis elegans
Bruno van Swinderen, Owais Saifee, Laynie Shebester, Russell Roberson, Michael L. Nonet, and C. Michael Crowder
Blockade of N-methyl-D-aspartate receptor activation 2485-2490 suppresses learning-induced synaptic elimination
Jorg Bock and Katharina Braun
Cloning, expression, and genetic mapping of 2491-2496 Sema W, a member of the semaphorin family
Jeffrey A. Encinas, Kaoru Kikuchi, Alain Chedotal, Fernando de Castro, Corey S. Goodman, and Toru Kimura
Reverse genetic analysis of Caenorhabditis elegans 2497-2502 presenilins reveals redundant but unequal roles for sel-12 and hop-i in Notch-pathway signaling
Bethany Westlund, Dianne Parry, Ralph Clover, Michael Basson, and Carl D. Johnson
PHARMACOLOGY
G35 prevents the RGS7-Gao interaction through 2503-2507 binding to a distinct Gy-like domain found in RGS7 and other RGS proteins
Konstantin Levay, Jorge L. Cabrera, Daulet K. Satpaev, and Vladlen Z. Slepak
N-Methyl-l1-aspartate antagonists and apoptotic cell 2508-25 13 death triggered by head trauma in developing rat brain
D. Pohl, P. Bittigau, M. J. Ishimaru, D. Stadthaus, C. Hubner, J. W. Olney, L. Turski, and C. Ikonomidou
PHYSIOLOGY
Epithelial sodium channel regulated by 2514-2519 aldosterone-induced protein sgk
Sei-yu Chen, Aditi Bhargava, Luca Mastroberardino, Onno C. Meijer, Jian Wang, Patricia Buse, Gary L. Firestone, Francois Verrey, and David Pearce
Hormonal prevention of breast cancer: Mimicking 2520-2525 the protective effect of pregnancy
Raphael C. Guzman, Jason Yang, Lakshmanaswamy Rajkumar, Gudmundur Thordarson, Xiaoyan Chen, and Satyabrata Nandi
Two gonadotropin-releasing hormone receptor 2526-2531 subtypes with distinct ligand selectivity and differential distribution in brain and pituitary in the goldfish (Car-assius aur-atus)
Nicola Illing, Brigitte E. Troskie, Carol S. Nahorniak, Janet P. Hapgood, Richard E. Peter, and Robert P. Millar
Correlation of regional cerebral blood flow and 2532-2537 change of plasma sodium concentration during genesis and satiation of thirst
Derek Denton, Robert Shade, Frank Zamarippa, Gary Egan, John Blair-West, Michael McKinley, and Peter Fox
Tonicity-responsive enhancer binding protein, a 2538-2542 Rel-like protein that stimulates transcription in response to hypertonicity
Hiroshi Miyakawa, Seung Kyoon Woo, Stephen C. Dahl, Joseph S. Handler, and H. Moo Kwon * See Comnmentary on page 1814
Modulation of the baboon (Papio anlubis) uterine 2543-2548 endometrium by chorionic gonadotrophin during the period of uterine receptivity
Asgerally T. Fazleabas, Kathleen M. Donnelly, Sudha Srinivasan, Jeffrey D. Fortman, and Josephine B. Miller
ix
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Expression of alfalfa mosaic virus coat protein in 2549-2553 tobacco mosaic virus (TMV) deficient in the production of its native coat protein supports long-distance movement of a chimeric TMV
S. Spitsin, K. Steplewski, N. Fleysh, H. Belanger, T. Mikheeva, S. Shivprasad, W. Dawson, H. Koprowski, and V. Yusibov
Male gametic cell-specific gene expression in 2554-2558 flowering plants
Huiling Xu, Ines Swoboda, Prem L. Bhalla, and Mohan B. Singh
Social Sciences
ANTHROPOLOGY
Canine sexual dimorphism in Egyptian Eocene 2559-2562 anthropoid primates: Catopithecus and Pr-oteopithecus
Elwyn L. Simons, J. Michael Plavcan, and John G. Fleagle
Prehistoric birds from New Ireland, Papua New 2563-2568 Guinea: Extinctions on a large Melanesian island
David W. Steadman, J. Peter White, and Jim Allen
CORRECTIONS
CELL BIOLOGY
ADP-ribosylation factor and phosphatidic acid levels 2569 in Golgi membranes during budding of coatomer-coated vesicles
Mark Stamnes, Giampietro Schiavo, Gudrun Stenbeck, Thomas H. S1llner, and James E. Rothman
MEDICAL SCIENCES Gadolinium(III) texaphyrin: A tumor selective 2569 radiation sensitizer that is detectable by MRI
Stuart W. Young, Fan Qing, Anthony Harriman, Jonathan L. Sessler, William C. Dow, Tarak D. Mody, Gregory W. Hemmi, Yunpeng Hao, and Richard A. Miller
Production of f-defensins by human airway epithelia 2569 Pradeep K. Singh, Hong Peng Jia, Kerry Wiles, Jay Hesselberth, Lide Liu, Barbara-Ann D. Conway, Everett P. Greenberg, Erika V. Valore, Michael J. Welsh, Tomas Ganz, Brian F. Tack, and Paul B. McCray, Jr.
A multidrug resistance transporter from human 2569 MCF-7 breast cancer cells
Austin Doyle, Weidong Yang, Lynne V. Abruzzo, Tammy Krogmann, Yongming Gao, Arun K. Rishi, and Douglas D. Ross
AUTHOR INDEX xi-xiv
INFORMATION FOR AUTHORS xv-xvii
SIZING WORKSHEET xviii
DOCUMENTATION REPORT xix
COPYRIGHT ASSIGNMENT FORM xx
SUBSCRIPTION FORM xxi
CLASSIFIED ADVERTISEMENTS xxii
Cover photograph: The Great Hall at the National Academy of Sciences has a central dome with eight radial panels. Each panel contains a figure symbolizing one of the principal divisions of science. The cover photograph features Botany.
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