Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 76, No. 1 (Jan., 1979), pp. v-xiiPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/69417 .

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JANUARY 1979

VOLUME 76

NUMBER 1

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THE PROCEEDINGS OF THE

National Academy of Sciences OF THE UNITED STATES OF AMERICA

Officers PHILIP HANDLER President of the SAUNDERS MAC LANE Vice President Academy DAVID R. GODDARD Home Secretary

THOMAS F. MALONE Foreign Secretary E. R. PIORE Treasurer

Editorial Board ROBERT L. SINSHEIMER Chairman of the HARRISON SHULL Vice Chairman Proceedings DAVID R. GODDARD Home Secretary

THOMAS F. MALONE Foreign Secretary E. R. PIORE Treasurer

K. FRANK AUSTEN JOHN R. BORCHERT P. D. BOYER JULIUS H. COMROE, JR. JOHN E. DOWLING HARRY EAGLE RICHARD M. HELD HENRY S. KAPLAN

DANIEL E. KOSHLAND, JR. S. M. LIPSETI NEVIN S. SCRIMSHAW

E. R. STADTMAN ELIAS M. STEIN HOWARD M. TEMIN JAMES TOBIN CHARLES H. TOWNES

JAMES B. WYNGAARDEN

Managing Editor: BERNARD K. FORSCHER Associate Editor: GARY T. COCKS Associate Editor: MURRIE W. BURGAN Associate Editor: SHEILA L. ROSENTHAL Assistant Managing Editor: STEPHANIE G. PASSMAN

Editorial correspondence: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, Washington, DC 20418.

Business correspondence: Circulation Office of the PROCEEDINGS, National Academy of Sciences, 2101 Constitution Avenue, Washington, DC 20418.

Copyright: The National Academy of Sciences has copyrighted this journal as a collective work and does not own copyrights for individual articles. For reprints of individual articles, requests should be addressed to the authors. Microforms of complete volumes are available to regular subscribers only and may be obtained from University Microfilms, Xerox Corporation, Ann Arbor, MI 48103.

Subscriptions: All correspondence concerning subscriptions should be addressed to the Circulation Office of the Proceedings. Subscriptions are entered on a calendar year basis only. The 1979 subscription rate is $60. Subscribers are requested to notify the Circulation Office of the Proceedings 6 weeks in advance of any change of address; also the local postmaster. The Academy is not responsible for nonreceipt of issues because of improper address unless a change of address is on file. The notice of address change should list both the old and new addresses. Claims for replacement copies will not be honored more than 60 days after the issue date for domestic subscribers and not more than 90 days after the issue date for foreign subscrib- ers.

Back Issues: Volumes 1-70, through December 1973, are available from Walter J. Johnson, Inc., 355 Chestnut Street, Nor- wood, NJ 07648. Prices are available from that organization upon request. Volumes 71-75, January 1974 and thereafter, are available from the Circulation Office of the Proceedings. The price of a single issue is $7.50.

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA is published monthly by THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, Washington, DC 20418.

? 1979 by THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.

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AUTHOR INDEX, JANUARY 1979

Ackers, G. K. 273 Adams, D. 0. 170 Adler, J. 260 Adler, M. 531 Agabian, N. 175 Ahrens, H. 66 Albuquerque, E. X. 531 Alvarado, J. 464 Anderegg, R. J. 227 Andersen, J. M. 165 Arntzen, C. J. 278 Axelrod, J. 368 Azbel, M. Y. 101 Bach, M.-L. 386 Baker, H. 509 Ball, C. B. 260 Barker, L. J. 179 Barnes, W. M. 546 Barranger, J. A. 481 Bartels, E. 256 Basu, S. K. 333 Bauer, C.-A. 96 Bechtol, K. B. 363 Benacerraf, B. 442 Bern, H. A. 536 Beutler, E. 473 Bhargava, H. N. 518 Biemann, K. 227 Biniaminov, M. 447 Bisbee, C. A. 536 Bissell, M. J. 348 Black, P. H. 246 Blake, D. A. 303 Blanchard, S. G. 81 Blobel, G. 343 Bloom, B. R. 476 Bloom, W. 116 Blumberg, B. M. 251 Bodemer, M. 430 Boersma, D. 415 Bolivar, F. 106 Boon, P. J. 61 Borisy, G. G. 293 Botstein, D. 386 Bottenstein, J. E. 514 Brady, R. 0. 481 Braughler, J. M. 219 Brayer, G. D. 96 Brewer, P. E. 278 Brezis, H. 38 Browder, F. E. 38 Brown, M. S. 333 Brown, S. C. 363 Bruns, R. R. 313 Bujard, H. 189 Bulinski, J. C. 293 Burakoff, S. J. 442 Cain, K. T. 435 Calvin, M. 348 Canuel, L. L. 24 Carrella, M. 338 Cascino, D. 288 Case, K. M. 1 Caspari, D. 494 Cavalli-Sforza, L. L. 420 Chesebro, B. 425 Chestier, A. 46 Chiu, C. C. 223 Christopher, C. W. 546 Chu, E. H. Y. 303 Chua, N.-H. 111 Cochran, B. C. 214 Cooper, A. D. 338 Correa, F. M. A. 521 Crea, R. 106 Cremer, K. J. 430

Crow, J. F. 396 Cuatrecasas, P. 121 Dabrowska, R. 184 Dale, G. L. 473 Darzynkiewicz, Z. 358 Das, M. 547 Delbaere, L. T. J. 96 Delepelaire, P. 111 Deutsch, W. A. 141 Dewey, M. J. 546 Dietschy, J. M. 165 Ditto, C. L. 278 Echols, H. 150 Edelman, I. 400 Eldefrawi, A. T. 531 Eldefrawi, M. E. 531 Enoch, H. G. 145 Erlanger, B. F. 256 Essigmann, J. M. 179 Evenson, D. 358 Evinger, M. 175 Eyring, G. 33 Fall, R. R. 214 Feldman, M. W. 420 Fellous, A. 86 Ferguson-Miller, S. 155 Fernandes, G. 457 Fiebig, K. 494 Fields, B. N. 442 Finberg, R. 442 Fischbach, G. D. 526 Fischer, R. 150 Flexner, L. B. 518 Floyd, R. 457 Fowler, K. W. 179 Fox, C. F. 547 Francisco, M. A. 179 Francon, J. 86 Frangione, B. 452 Franklin, E. C. 452 Fredericks, W. R. 481 Freier, S. M. 51 Gammon, M. T. 546 Gefter, M. L. 160 Generoso, W. M. 435 Gerber, G. E. 227 Gesteland, R. F. 430 Gevers, W. 353 Giesecke, K. 76 Goeddel, D. V. 106 Goldman, R. D. 184 Goldstein, I. J. 303 Goldstein, J. L. 333 Good, R. A. 457 Goodfellow, P. N. 377 Gospodarowicz, D. 464 Gottschalk, G. 494 Gray, C. P. 227 Greenburg, G. 464 Griffith, 0. W. 268 Groner, B. 76 Gross, J. 313 Gruss, A. D. 400 Hall, L. M. 499 Hall, Z. W. 504 Hamilton, T. A. 323 Hankinson, 0. 373 Hartshorne, D. J. 184 Hastings, J. W. 265 Hatie, C. 348 Heller, M. J. 51 Herlihy, W. C. 227 Herskowitz, I. 150 Heyneker, H. L. 106 Hildebrand, J. G. 499 Hildebrand, J. H. 194

Hill, T. L. 232 Hilmen, M. 391 Hippe, H. 494 Hirata, F. 368 Hirose, T. 106 Ho, Y. K. 333 Hori, H. 381 Huff, S. W. 435 Hulmes, D. J. S. 313 Imae, Y. 91 Innis, R. B. 521 Inouye, M. 209 Inouye, S. 209 Isselbacher, K. J. 546 Itakura, K. 106 Jaken, S. 246 James, M. N. G. 96 Joh, T. H. 509 Jones, M. 0. 150 Jones, P. A. 353 Jose, J. G. 469 Kaplan, B. E. 486 Karlin, S. 541 Karpatkin, M. 491 Karpatkin, S. 491 Kennett, R. H. 363 Kezdy, F. J. 251 Khorana, H. G. 227 Khoury, G. 71 Kimura, M. 396 Kimura, M. 486 Kleid, D. G. 106 Klotz, I. M. 51 Kochwa, S. 116 Kolodner, R. 41 Kondoh, H. 260 Kourides, I. A. 298 Kraszewski, A. 106 Krishna, M. 435 Kuhl, W. 473 Lacroute, F. 386 Lai, C.-J. 71 Lalazar, A. 318 Land, H. 76 Lapetina, E. G. 121 La Porte, D. C. 204 Lau, E. P. 214 Lau, Y. Y. 4 Leeman, S. E. 526 Lehman, I. R. 126 Lennon, A. M. 86 Letsinger, R. L. 51 Levinson, J. R. 377 Lightner, D. A. 29 Lin, P.-F. 405 Linn, S. 141 Loyter, A. 318 Maccecchini, M.-L. 343 McConnell, H. M. 15 MacDermot, K. D. 481 McDevitt, H. 0. 377 McDonagh, A. F. 29 McEntee, K. 126 McGill, S. M. 415 Machen, T. E. 536 Macino, G. 131 Maeda, K. 91 Magdoff-Fairchild, B.

223 Mandel, G. 236 Manley, J. L. 160 Margoliash, E. 155 Mathies, R. 33 Matranga, V. 288 Meister, A. 268 Melamed, M. R. 358

v

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AUTHOR INDEX, JANUARY 1979

Mellman, I. S. 405 Mills, F. C. 273 Mintz, B. 546 Mitelman, F. 462 Mittal, C. K. 219 Mollenkamp, J. W. 415 Mudge, A. W. 526 Munro, 1. 56 Munson, L. 214 Murad, F. 219 Nagy, B. 10 Nagylaki, T. 438 Nair, M. 457 Nakamoto, T. 251 Neighbour, P. A. 476 Ng, S. Y. 136 Nguyen-Huu, M. C. 76 Nishino, H. 546 Nivard, R. J. F. 61 Noll, H. 288 Novick, R. P. 400 Nunez, J. 86 Oliveira, A. C. 531 Onoe, K. 457 Ores, C. 116 Osawa, S. 381 Osheroff, N. 155 Osmnond, B. C. 499 Pannatoni, R. F. 4 Parker, C. S. 136 Patel, D. J. 24 Pattee, P. A. 400 Pecht, I. 56 Pentchev, P. G. 481 Pero, R. W. 462 Peters, B. P. 303 Petes, T. D. 410 Picard, B. 241 Pitot, H. C. 283 Prelli, F. 452 Puszkin, S. 116 Raftery, M. A. 81 Ramot, B. 447 Rapoport, S. I. 481 Reinhold, V. N. 179 Reis, D. J. 509 Reisner, Y. 447 Richards, W. 283

Riggs, A. D. 106 Riley, D. 328 Ritzmann, R. F. 518 Roeder, R. G. 136 Rosenberg, L. E. 405 Rosenthal, E. 447 Roufa, D. J. 415 Rubenstein, J. L. R. 15 Ruddle, F. H. 405 Rudin, Y. 343 Salemme, F. R. 19 Sato, G. H. 514 Sattler, C. A. 283 Schatz, G. 343 Schiller, R. M. 546 Schneider, B. 521 Schook, W. 116 Schutz, G. 76 Schwesinger, M. D. 400 Scott-Burden, T. 353 Seitz, W. A. 8 Shanker, G. 66 Sharma, R. K. 66 Sharon, N. 447 Sharp, P. A. 160 Sharpless, T. 358 Shier, W. T. 195 Silverman, M. 391 Simon, M. 391 Sippel, A. E. 76 Sirica, A. E. 283 Sklarew, D. S. 10 Smith, B. A. 15 Snyder, S. H. 521 Speck, S. H. 155 Staiano-Coico, L. 358 Stanford, E. 308 Stanley, W. S. 303 Steusing, J. K. 481 Storm, D. R. 204 Stratmann, M. 76 Strittmatter, P. 145 Strittmatter, W. J. 368 Stryer, L. 56 Summers, W. C. 430 Summers, W. P. 430 Sussman, H. H. 323 Swanson, E. C. 400

Tanaka, T. 457 Teitelman, G. 509 Tesser, G. I. 61 Tewari, K. K. 41 Therrien, S. F. 313 Thompson, R. C. 96 Tin, A. W. 323 Town, C. 308 Tsukada, Y. 283 Turley, S. D. 165 Tzagoloff, A. 131 Uhl, G. R. 521 Ulitzur, S. 265 Ullrey, D. 546 Uyenoyama, M. 420 Vittorelli, L. 288 von Gabain, A. 189 Walder, J. A. 51 Walder, R. Y. 51 Wall, F. T. 8 Walter, R. 518 Wang, J. C. 200 Wassermann, N. H. 256 Watanabe, T. 546 Weatherford, D. W. 19 Wegnez, M. 241 Wehrly, K. 425 Weinberg, C. B. 504 Weiner, H. L. 442 Weinstock, G. M. 126 Weintraub, B. D. 298 Weintraub, H. 328 Westcott, K. R. 204 Wickner, W. 236 Williams, V. E., II 377 Wogan, G. N. 179 Wooldridge, T. A. 29 Wurtz, T. 76 Yang, S. F. 170 Yaniv, M. 46 Yansura, D. G. 106 Yep, D. 303 Yerna, M.-J. 184 Yoshida, A. 486 Zieg, J. 391 Zusman, D. R. 209

vi

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Contents (Continued from page ix)

Antibodies from patients with myasthenia gravis recognize determinants unique Crispin B. Weinberg and Zach W. 504-508 to extrajunctional acetylcholine receptors (junctional acetylcholine Hall receptors/skeletal muscle/embryonic acetylcholine receptors)

Appearance of catecholamine-synthesizing enzymes during development of rat Gladys Teitelman, Harriet Baker, 509-513 sympathetic nervous system: Possible role of tissue environment Tong H. Joh, and Donald J. Reis [immunocytochemistry/tyrosine 3-monooxygenase (tyrosine hydroxylase)/ dopamine-j3-hydroxylase/phenylethanolamine N-methyltransferase]

Growth of a rat neuroblastoma cell line in serum-free supplemented medium Jane E. Bottenstein and Gordon H. 514-517 (growth regulation/B104 cells/neurite extension/central nervous system) Sato

Prolyl-leucyl-glycinamide, cyclo(leucylglycine), and derivatives block Roderich Walter, Ronald F. 518-520 development of physical dependence on morphine in mice (addiction/ Ritzmann, Hemendra N. Bhargava, withdrawal/peptides/structure-activity relationship/antagonist) and Louis B. Flexner

Cholecystokinin octapeptide-like immunoreactivity: Histochemical localization Robert B. Innis, Fernando M. A. 521-525 in rat brain (peptide/indirect immunofluorescence/central nervous system) Correa, George R. Uhl, Bruce

Schneider, and Solomon H. Snyder

Enkephalin inhibits release of substance P from sensory neurons in culture and Anne W. Mudge, Susan E. Leeman, 526-530 decreases action potential duration (peptides/opiates/calcium) and Gerald D. Fischbach

Tetraethylammonium: Voltage-dependent action on endplate conductance and Michael Adler, Antonio C. Oliveira, 531-535 inhibition of ligand binding to postsynaptic proteins (acetylcholine Mohyee E. Eldefrawi, Amira T. receptor/endplate channel/acetylcholine noise/perhydrohistrionicotoxin/ Eldefrawi, and Edson X. Torpedo electroplax) Albuquerque

PHYSIOLOGICAL SCIENCES

Mouse mammary epithelial cells on floating collagen gels: Transepithelial ion Chester A. Bisbee, Terry E. Machen, 536-540 transport and effects of prolactin (active Na+ transport/primary cell and Howard A. Bern culture/midpregnant cells/cell differentiation/milk ions)

POPULATION BIOLOGY

Principles of polymorphism and epistasis for multilocus systems (linkage/ Samuel Karlin 541-545 nonepistasis/symmetric selection/multilocus Hardy-Weinberg equilibrium/gametic and allelic polymorphisms)

Corrections

CELL BIOLOGY

Sodium-dependent amino acid transport by cultured hamster cells: Membrane Hoyoku Nishino, C. William 546 vesicles retain transport changes due to glucose starvation and Christopher, Robert M. Schiller, cycloheximide (Nil cells/a-aminoisobutyrate/fructose feeding/regulation) Maureen T. Gammon, Donna

Ullrey, and Kurt J. Isselbacher

GENETICS

Teratocarcinoma cells as vehicles for introducing specific mutant mitochondrial Tomomasa Watanabe, Michael J. 546 genes into mice (chloramphenicol resistance/cytoplasmic inheritance/ Dewey, and Beatrice Mintz melanoma/cybrid cells/hybrid cells)

BIOCHEMISTRY

DNA sequence from the histidine operon control region: Seven histidine codons Wayne M. Barnes 546 in a row (genetic regulation/transcription/attenuation)

Molecular mechanism of mitogen action: Processing of receptor induced by Manjusri Das and C. Fred Fox 547 epidermal growth factor (radiolabeled hormone receptors/down regulation of hormone receptors/receptor internalization/DNA synthesis/mitogenic hormone)

viii

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Contents (Continued from page x)

In vitro suppression of UAG and UGA mutants in the thymidine kinase gene Kenneth J. Cremer, Monika 430-434 of herpes simplex virus (nonsense/amber mutants/mammalian genetics) Bodemer, Wilma P. Summers,

William C. Summers, and Raymond F. Gesteland

Genetic lesions induced by chemicals in spermatozoa and spermatids of mice Walderico M. Generoso, Katherine 435-437 are repaired in the egg (repair in fertilized eggs/germ-cell mutagenesis/ T. Cain, Maryala Krishna, and dominant-lethal mutations) Sandra W. Huff

Dynamics of density- and frequency-dependent selection (population genetics/ Thomas Nagylaki 438-441 ecology/evolution/population regulation)

Teratocarcinoma cells as vehicles for introducing specific mutant mitochondrial Tomomasa Watanabe, Michael J. 546 genes into mice (Correction) (chloramphenicol resistance/cytoplasmic Dewey, and Beatrice Mintz inheritance/melanoma/cybrid cells/hybrid cells)

IMMUNOLOGY

Generation of cytolytic T lymphocytes after reovirus infection: Role of S1 gene Robert Finberg, Howard L. Weiner, 442-446 (viral immunity/recombinant viral clones/cell-mediated immunity) Bernard N. Fields, Baruj

Benacerraf, and Steven J. Burakoff

Interaction of peanut agglutinin with normal human lymphocytes and with Yair Reisner, Miriam Biniaminov, 447-451 leukemic cells (lectin/human thymocytgs/acute leukemia/chronic Esther Rosenthal, Nathan Sharon, leukemia) and Bracha Ramot

Human heavy chain disease protein WIS: Implications for the organization of Edward C. Franklin, Frances Prelli, 452-456 immunoglobulin genes (intervening sequences/gene splicing/mutations/ and Blas Frangione deletions)

Impairment of cell-mediated immunity functions by dietary zinc deficiency in Gabriel Fernandes, Madhavan Nair, 457-461 mice (thymic atrophy/T killer cells/natural killer cells) Kazunori Onoe, Toshio Tanaka,

Rachael Floyd, and Robert A. Good

MEDICAL SCIENCES

Another approach to in vivo estimation of genetic damage in humans (genetic Ronald W. Pero and Felix Mitelman 462-463 risk/unscheduled DNA synthesis/chromosome aberrations/N-acetoxy-2- acetylaminofluorene/DNA repair)

Transplantation of cultured bovine corneal endothelial cells to rabbit cornea: Denis Gospodarowicz, Gary 464-468 Clinical implications for human studies (keratoplasty/corneal endothelium/ Greenburg, and Jorge Alvarado fibroblast growth factor)

Photomutagenesis by chlorinated phenothiazine tranquilizers (cataracts/ Jule Griebrok Jose 469-472 photodermatitis/photodehalogenation/drug design)

Incorporation of glucocerebrosidase into Gaucher's disease monocytes in vitro G. L. Dale, W. Kuhl, and E. Beutler 473-475 (enzyme replacement therapy/l3-glucosidase/erythrocyte entrapment of enzyme)

Absence of virus-induced lymphocyte suppression and interferon production P. Andrew Neighbour and Barry R. 476-480 in multiple sclerosis (cell-mediated immunity/suppressor cell/viral Bloom antigens/slow neurologic diseases)

Modification of the blood-brain barrier: Increased concentration and fate of John A. Barranger, Stanley I. 481-485 enzymes entering the brain (arabinose/mannosidase/horseradish Rapoport, Wendy R. Fredericks, peroxidase/lysosomes) Peter G. Pentchev, Kaye D.

MacDermot, Jan K. Steusing, and Roscoe 0. Brady

Metal-binding and detoxification effect of synthetic oligopeptides containing Akira Yoshida, Bruce E. Kaplan, and 486-490 three cysteinyl residues (metallothionein/metal-binding peptide/metal Masami Kimura poisoning)

Humoral factor that specifically regulates prothrombin (Factor II) levels Margaret Karpatkin and Simon 491-493 (coagulopoietin-II) (rabbit prothrombin/in vitro liver system) Karpatkin

MICROBIOLOGY

Utilization of trimethylamine and other N-methyl compounds for growth and H. Hippe, D. Caspari, K. Fiebig, and 494-498 methane formation by Methanosarcina barkeri (methanogenesis/choline G. Gottschalk and betaine ferment ation/creatine/sarcosine/growth yields)

NEUROBIOLOGY

Distribution of binding sites for 1251-labeled a-bungarotoxin in normal and John G. Hildebrand, Linda M. Hall, 499-503 deafferented antennal lobes of Manduca sexta (acetylcholine receptors/ and BSarbara C. Osmond synaptic development/insect central nervous system)

l((ontinued on pagnfe viii)

ix

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Contents (Continued from page xi)

Import of proteins into mitochondria: Precursor forms of the Maria-Luisa Maccecchini, Yvonne 343-347 extramitochondrially made F1-ATPase subunits in yeast (translation in Rudin, Gunter Blobel, and reticulocyte cell-free system/immunoprecipitation/processing and Gottfried Schatz segregation by mitochondria/in vivo pulse-chase)

Is the product of the src gene a promoter? (Rous sarcoma virus/phorbol esters! M. J. Bissell, C. Hatie, and M. Calvin 348-352 chicken cells/collagen/viral carcinogenesis)

Glycoprotein, elastin, and collagen secretion by rat smooth muscle cells Peter A. Jones, Timothy 353-357 (differentiation/extracellular matrix/smooth muscle sublines) Scott-Burden, and Wieland Gevers

Relationship between RNA content and progression of lymphocytes through S Z. Darzynkiewicz, D. Evenson, L. 358-362 phase of cell cycle (flow cytometry/DNA synthesis rate/lymphocyte Staiano-Coico, T. Sharpless, and stimulation) M. R. Melamed

Recognition of differentiation antigens of spermatogenesis in the mouse by Kathleen B. Bechtol, Shannon C. 363-367 using antibodies from spleen cell-myeloma hybrids after syngeneic Brown, and Roger H. Kennett immunization (monoclonal antibodies/hybridomas/tissue-specific antigens)

f-Adrenergic receptor agonists increase phospholipid methylation, membrane Fusao Hirata, Warren J. 368-372 fluidity, and f3-adrenergic receptor-adenylate cyclase coupling (membrane Strittmatter, and Julius Axelrod translocation/fluidity/S-adenosylmethionine/reticulocytes)

Single-step selection of clones of a mouse hepatoma line deficient in aryl Oliver Hankinson 373-376 hydrocarbon hydroxylase (carcinogen/benzo[a]pyrene-resistant clones/ stability/fluctuation test)

Sodium-dependent amino acid transport by cultured hamster cells: Membrane Hoyoku Nishino, C. William 546 vesicles retain transport changes due to glucose starvation and Christopher, Robert M. Schiller, cycloheximide (Correction) (Nil cells/a-aminoisobutyrate/fructose feeding/ Maureen T. Gammon, Donna regulation) Ullrey, and Kurt J. Isselbacher

DEVELOPMENTAL BIOLOGY

Monoclonal antibodies reacting with murine teratocarcinoma cells Peter N. Goodfellow, John R. 377-380 (radioimmunoassay/cultured cells/adult tissues/preimplanation embryos) Levinson, Virginia E. Williams II,

and Hugh 0. McDevitt

EVOLUTION

Evolutionary change in 5S RNA secondary structure and a phylogenic tree of Hiroshi Hori and Syozo Osawa 381-385 54 5S RNA species (5S RNA models/nucleotide alignments/classification of 5S RNAs)

GENETICS

Evidence for transcriptional regulation of orotidine-5'-phosphate decarboxylase Marie-Louise Bach, Francois 386-390 in yeast by hybridization of mRNA to the yeast structural gene cloned in Lacroute, and David Botstein Escherichia coli (complementation/in vitro recombination/Saccharomyces cerevisiae/pyrimidine biosynthesis)

Phase variation in Salmonella: Genetic analysis of a recombinational switch Michael Silverman, Janine Zieg, 391-395 (gene expression/inversion/flagellar antigen) Marcia Hilmen, and Melvin Simon

Efficiency of truncation selection (rank-order selection/fitness potential/ James F. Crow and Motoo Kimura 396-399 mutation load/viability/fitness)

Genetic translocation in Staphylococcus aureus (transposon/erythromycin Richard P. Novick, Irit Edelman, 400-404 resistance/insertional inactivation/staphylococcal plasmids) Marjorie D. Schwesinger,

Alexandra D. Gruss, Evryll C. Swanson, and Peter A. Pattee

Genetic control of cobalamin binding in normal and mutant cells: Assignment Ira S. Mellman, Pin-Fang Lin, Frank 405-409 of the gene for 5-methyltetrahydrofolate:L-homocysteine H. Ruddle, and Leon E. Rosenberg S-methyltransferase to human chromosome 1 (gene mapping/ complementation analysis/vitamin B-12/human genetic disease/ tetrahydropteroylglutamate methyltransferase)

Yeast ribosomal DNA genes are located on chromosome XII (aneuploid Thomas D. Petes 410-414 mapping/mitotic recombination)

Emetine resistance in Chinese hamster cells is linked genetically with an altered D. Boersma, S. M. McGill, J. W. 415-419 40S ribosomal subunit protein, S20* (somatic cell genetics/two-dimensional Mollenkamp, and D. J. Roufa gel electrophoresis/mitotic segregation/hybrid cells)

Evolutionary effects of contagious and familial transmission (genetics/ M. Uyenoyama, M. W. Feldman, and 420-424 epidemics/population dynamics/polymorphism/cultural transmission) L. L. Cavalli-Sforza

Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and Bruce Chesebro and Kathy Wehrly 425-429 leukemia induced by Friend virus complex (murine leukemia virus/ erythroleukemia/immune response genes/H-2 and non-H-2 gene interactions)

(Continued on page ix )

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Contents (Continued from page xii)

Identification of a methyl-accepting chemotaxis protein for the ribose and Hisato Kondoh, Carl B. Ball, and 260-264 galactose chemoreceptors of Escherichia coli (binding proteins/trg- Julius Adler mutants)

Evidence for tetradecanal as the natural aldehyde in bacterial bioluminescence S. Ulitzur and J. W. Hastings 265-267 (fatty acids/luciferase/bacterial luminescence)

Translocation of intracellular glutathione to membrane-bound y-glutamyl Owen W. Griffith and Alton Meister 268-272 transpeptidase as a discrete step in the 'y-glutamyl cycle: Glutathionuria after inhibition of transpeptidase (prothionine sulfoximine/y-glutamyl hydrazides/6-diazo-5-oxonorleucine/kidney/glutathionemia)

DNA sequence from the histidine operon control region: Seven histidine codons Wayne M. Barnes 546 in a row (Correction) (genetic regulation/transcription/attenuation)

Molecular mechanism of mitogen action: Processing of receptor induced by Manjusri Das and C. Fred Fox 547 epidermal growth factor (Correction) (radiolabeled hormone receptors! down regulation of hormone receptors/receptor internalization/DNA synthesis/mitogenic hormone)

BIOPHYSICS

Quaternary enhancement in binding of oxygen by human hemoglobin Frederick C. Mills and Gary K. 273-277 (allostery/thermodynamics/proteins/linkage) Ackers

BOTANY

Chloroplast membrane alterations in triazine-resistant Amaranthus retroflexus Charles J. Arntzen, Cathy L. Ditto, 278-282 biotypes (triazine herbicides/diuron/photosystem II/pesticide resistance) and Philip E. Brewer

CELL BIOLOGY

Fetal phenotypic expression by adult rat hepatocytes on collagen gel/nylon Alphonse E. Sirica, William 283-287 meshes (y-glutamyl transpeptidase/al-fetoprotein/aldolase/DNA Richards, Yutaka Tsukada, Carol synthesis/microfilaments) A. Sattler, and Henry C. Pitot

Reconstitution of membranes and embryonic development in dissociated Hans Noll, Valeria Matranga, 288-292 blastula cells of the sea urchin by reinsertion of aggregation-promoting Domenico Cascino, and Letizia membrane proteins extracted with butanol (cell surface recognition Vittorelli proteins/cell-cell binding/change of phenotype)

Self-assembly of microtubules in extracts of cultured HeLa cells and the Jeannette Chloe Bulinski and Gary 293-297 identification of HeLa microtubule-associated proteins (polymerization/ G. Borisy tubulin)

mRNA-directed biosynthesis of a subunit of thyrotropin: Translation in Ione A. Kourides and Bruce D. 298-302 cell-free and whole-cell systems (secretory glycoprotein hormone/mouse Weintraub thyrotropic pituitary tumor/independent synthesis of thyrotropin subunits)

Interaction of wild-type and variant mouse 3T3 cells with lectins from Wayne S. Stanley, Barry P. Peters, 303-307 Bandeiraea simplicifolia seeds (lectin resistance/cell membrane Diane A. Blake, Dennis Yep, alterations/cytotoxicity) Ernest H. Y. Chu, and Irwin J.

Goldstein

An oligosaccharide-containing factor that induces cell differentiation in Chris Town and Eileen Stanford 308-312 Dictyostelium discoideum (cell interaction/cyclic AMP/pattern formation)

Procollagen segment-long-spacing crystallites: Their role in collagen Romaine R. Bruns, David J. S. 313-317 fibrillogenesis (macromolecular aggregates/exocytosis/cell culture/tissue Hulmes, Stephen F. Therrien, and homogenates/electron microscopy) Jerome Gross

Involvement of spectrin in membrane fusion: Induction of fusion in human Avraham Lalazar and Abraham 318-322 erythrocyte ghosts by proteolytic enzymes and its inhibition by antispectrin Loyter antibody (Sendai virus/cell agglutination/cell lysis/membrane proteins)

Regulation of alkaline phosphatase expression in human choriocarcinoma cell Thomas A. Hamilton, Agnes W. Tin, 323-327 lines (isoenzymes/two-dimensional electrophoresis) and Howard H. Sussman

Conservative segregation of parental histones during replication in the presence Donald Riley and Harold Weintraub 328-332 of cycloheximide (free DNA/Miller spreads/transcription units)

Binding site on macrophages that mediates uptake and degradation of Joseph L. Goldstein, Y. K. Ho, 333-337 acetylated low density lipoprotein, producing massive cholesterol deposition Sandip K. Basu, and Michael S. (cell surface receptor.s/denatured proteins/cultured cells/lysosomes/ Brown familial hypercholesterolemia)

High affinity binding of chylomicron remnants to rat liver plasma membranes Massimo Carrella and Allen D. 338-342 (lipoproteins/atherosclerosis/lipid metabolism) Cooper

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Contents (Continued from inside back cover)

RNA synthesis in isolated nuclei: In vitro initiation of adenovirus 2 major late James L. Manley, Philip A. Sharp, 160-164 mRNA precursor (transcription/mRNA "cap"/RNA polymerase IIIRNA and Malcolm L. Gefter processing)

Low and high density lipoproteins and chylomicrons as regulators of rate of John M. Andersen, Stephen D. 165-169 cholesterol synthesis in rat liver in vivo (cholesterol esters/lipoprotein Turley, and John M. Dietschy clearance/lipoprotein transport)

Ethylene biosynthesis: Identification of 1-aminocyclopropane-1-carboxylic acid D. 0. Adams and S. F. Yang 170-174 as an intermediate in the conversion of methionine to ethylene (S-adenosylmethionine/aminoethoxyvinylglycine/fruit ripening/apple)

Caulobacter crescentus nucleoid: Analysis of sedimentation behavior and Marian Evinger and Nina Agabian 175-178 protein composition during the cell cycle (prokaryotic differentiation! DNA-membrane interactions/envelope-associated chromosome complex! DNA replication)

Sterigmatocystin-DNA interactions: Identification of a major adduct formed J. M. Essigmann, L. J. Barker, K. W. 179-183 after metabolic activation in vitro (myocotoxins/chemical carcinogens! Fowler, M. A. Francisco, V. N. carcinogen-macromolecule interactions/DNA adducts/NMR spectroscopy) Reinhold, and G. N. Wogan

Calcium-sensitive regulation of actin-myosin interactions in baby hamster Marie-Jeanne Yerna, Renata 184-188 kidney (BHK-21) cells (nonmuscle contraction/phosphorylationl Dabrowska, David J. Hartshorne, adenosinetriphosphatase/myosin kinase/modulator) and Robert D. Goldman

Interaction of Escherichia coli RNA polymerase with promoters of several A. von Gabain and H. Bujard 189-193 coliphage and plasmid DNAs (complex formation/complex stability! promoter strength)

Is there a "hydrophobic effect"? Joel H. Hildebrand 194

Activation of high levels of endogenous phospholipase A2 in cultured cells W. Thomas Shier 195-199 (prostaglandin synthesis/melittin/direct lytic factor/calcium-dependent activity/cell membrane)

Helical repeat of DNA in solution (DNA structure/linking number/DNA James C. Wang 200-203 topoisomerase/closed circular DNA)

Resolution of adenylate cyclase sensitive and insensitive to Ca2+ and calcium- Keith R. Westcott, David C. La Porte, 204-208 dependent regulatory protein (CDR) by CDR-Sepharose affinity and Daniel R. Storm chromatography (brain cortex/cyclic AMP/modulator binding protein)

Biosynthesis and self-assembly of protein S, a development-specific protein of Masayori Inouye, Sumiko Inouye, 209-213 Myxococcus xanthus (spores/fruiting body/sodium dodecyl sulfate gel and David R. Zusman electrophoresis/calcium ion)

Bovine kidney 3-methylcrotonyl-CoA and propionyl-CoA carboxylases: Each Edward P. Lau, Bruce C. Cochran, 214-218 enzyme contains nonidentical subunits (mitochondria/immunoprecipitate/ Lianna Munson, and R. Ray Fall pig heart propionyl-CoA carboxylase)

Purification of soluble guanylate cyclase from rat liver (cyclic GMP/cyclic J. Mark Braughler, Chandra K. 219-222 AMP/nitroprusside/nitric oxide/fatty acids) Mittal, and Ferid Murad

X-ray diffraction studies of fibers and crystals of deoxygenated sickle cell Beatrice Magdoff-Fairchild and Celia 223-226 hemoglobin (polymer transformation into crystals/crystal model for C. Chiu polymer structure/pairs of staggered filaments/stabilization of double filaments by Val f36 contacts)

Partial primary structure of bacteriorhodopsin: Sequencing methods for Gerhard E. Gerber, Robert J. 227-231 membrane proteins (purple membrane/hydrophobic peptides/high- Anderegg, Walter C. Herlihy, pressure liquid chromatography/gas chromatographic mass spectrometryl Christopher P. Gray, Klaus sequencer analysis) Biemann, and H. Gobind Khorana

Coupled enzyme systems in a vesicular membrane: Oxidative phosphorylation Terrell L. Hill 232-235 as an example (ligand transport/steady-state kinetics/respiratory control)

Translational and post-translational cleavage of M13 procoat protein: Extracts Gail Mandel and William Wickner 236-240 of both the cytoplasmic and outer membranes of Escherichia coli contain leader peptidase activity (membrane assembly/M13 coat protein/signal hypothesis/membrane trigger hypothesis)

Isolation of a 7S particle from Xenopus laevis oocytes: A 5S RNA-protein Brigitte Picard and Maurice Wegnez 241-245 complex (oogenesis/ribonucleoprotein particles/ribosome unfolding)

Differences in intracellular distribution of plasminogen activator in growing, Susan Jaken and Paul H. Black 246-250 confluent, and transformed 3T3 cells (subcellular fractionation/protease/ cell surface)

Kinetics of initiation of bacterial protein synthesis (30S complex/mRNA/site BSenjamin M. Blumberg, Tokumasa 251-255 selection) Nakamoto, and Ferenc J. Kezdy

Conformational properties of the acetylcholine receptor as revealed by studies N. H. Wassermann, E. Bartels, and 256-259 with constrained depolarizing ligands (activators/inhibitors/dimensions of B@. F. Erlanger binding sites/binding site template/ligand flexibility)

(Conltinlued on pag,fe xi)

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