Front Matter Source: The Journal of Cell Biology, Vol. 177, No. 3 (May 7, 2007) Published by: The Rockefeller University Press Stable URL: http://www.jstor.org/stable/30049954 . Accessed: 25/06/2014 08:22 Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at . http://www.jstor.org/page/info/about/policies/terms.jsp . JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact [email protected]. . The Rockefeller University Press is collaborating with JSTOR to digitize, preserve and extend access to The Journal of Cell Biology. http://www.jstor.org This content downloaded from 188.72.126.47 on Wed, 25 Jun 2014 08:22:56 AM All use subject to JSTOR Terms and Conditions
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Front MatterSource: The Journal of Cell Biology, Vol. 177, No. 3 (May 7, 2007)Published by: The Rockefeller University PressStable URL: http://www.jstor.org/stable/30049954 .
Accessed: 25/06/2014 08:22
Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at .http://www.jstor.org/page/info/about/policies/terms.jsp
.JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range ofcontent in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new formsof scholarship. For more information about JSTOR, please contact [email protected].
.
The Rockefeller University Press is collaborating with JSTOR to digitize, preserve and extend access to TheJournal of Cell Biology.
http://www.jstor.org
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EDITORS PIER PAOLO DI FIORE ELAINE FUCHS ALAN HALL REBECCA HEALD LOUIS F. REICHARDT KENNETH M. YAMADA JUNYING YUAN
NEWS EDITORS NICOLE LEBRASSEUR WILLIAM A. WELLS RUTH WILLIAMS
REVIEWS EDITORS KAREN DELL LOUIS F. REICHARDT
EDITORIAL BOARD NORMA ANDREWS BEN BARRES HUGO BELLEN ANDREW BELMONT VANN BENNETT JEFFREY BENOVIC JUAN BONIFACINO TONY BRETSCHER MARIANNE BRONNER-FRASER ERIC J. BROWN DON W. CLEVELAND KENNETH CLINE PASCALE COSSART CAROLINE DAMSKY PIETRO DE CAMILLI ELISABETTA DEJANA RAY DESHAIES DAVID DRUBIN WILLIAM EARNSHAW ROBERT EISENMAN SCOTT EMR WERNER FRANKE HIRONORI FUNABIKI LARRY GERACE
MARK GINSBERG GILLIAN GRIFFITHS ULRICH HARTL NOBUTAKA HIROKAWA ERIKA HOLZBAUR ARTHUR HORWICH ALAN RICK HORWITZ M. ANDREW HOYT MARTIN HUMPHRIES ED HURT KENNETH JACOBSON GERARD KARSENTY TEYMURAS KURZCHALIA ARTHUR D. LANDER JEANNE LAWRENCE YURI LAZEBNIK VERONIQUE LEFEBVRE LESLIE LEINWAND RICHARD LEWIS LAURA MACHESKY JOAN MASSAGUE JACOPO MELDOLESI TOM MISTELI RANDALL T. MOON
SEAN MUNRO JODI NUNNARI ANDRE NUSSENZWEIG LESLIE PARISE MARK PEIFER ANNE RIDLEY CONLY RIEDER DANIEL B. RIFKIN DAVID RON MICHAEL RUDNICKI JOSHUA SANES TRINA SCHROER MARTIN SCHWARTZ JEAN SCHWARZBAUER RON VALE DAVID L. VAUX GRAHAM WARREN CLARE WATERMAN-STORER LOIS WEISMAN TIM YEN MARINO ZERIAL YIXIAN ZHENG
EXECUTIVE EDITOR EMMA HILL Phone: 212-327-8011 Fax: 212-327-8576 email: [email protected]
EDITORIAL ASSISTANTS LINDSEY HOLLANDER SATI MOTIERAM KARL RAMOS EMILY TAYLOR Phone: 21 2-327-8581 Fax: 21 2-327-8576 email: [email protected]
COPYEDITING AND PRODUCTION email: [email protected] PREFLIGHT COORDINATOR LAURA SMITH
THE APPEARANCE OF THE CODE AT THE BOTTOM OF THE FIRST PAGE OF AN ARTICLE IN THIS JOURNAL INDICATES THAT THE PUBLISHER GIVES CONSENT FOR INDIVIDUAL COPIES OF THAT ARTICLE TO BE MADE FOR PERSONAL OR INTERNAL USE. THIS CONSENT IS GIVEN ON THE CONDITION, HOWEVER, THAT-FOR COPYING BEYOND THE LIMITED QUANTITIES PERMITTED UNDER SECTIONS 107 OR 108 OF THE U.S. COPYRIGHT LAW-THE COPIER PAY THE STATED PER-COPY FEE, FOR THIS JOURNAL $15.00 PER ARTICLE, THROUGH THE COPYRIGHT CLEARANCE CENTER, INC., 222 ROSEWOOD DRIVE, DANVERS, MA 01923, PHONE: 978-750-8400, A NONPROFIT ORGANIZATION. THIS CONSENT DOES NOT EXTEND TO OTHER KINDS OF COPYING, SUCH AS COPYING FOR GENERAL DISTRIBUTION, FOR ADVERTISING OR PROMOTIONAL PURPOSES, FOR CREATING NEW COLLECTIVE WORKS, OR FOR RESALE.
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NEWS In This Issue 370 0 Emil ensures timely mitosis
* Hungry cells forget which way is up * The up side of a gas shortage * Breaking actin to rebuild it " When VEGF strays
M. Leslie
Research Roundup 372 S Motility from self-antigens
* Linking division and growth * Glycan growth switch * Immunity raises cholesterol * Cell fate depends on Golgi
N. LeBrasseur
People & Ideas 374 * Gero Miesenb6ck: instructing the nervous system
W.A. Wells
RESEARCH ARTICLES
Reports 377 The beginning of kinesin's force-generating cycle visualized
at 9-A resolution Charles V. Sindelar and Kenneth H. Downing
387 LKB 1 and AMPK maintain epithelial cell polarity under energetic stress Vincent Mirouse, Lance L. Swick, Nevzat Kazgan, Daniel StJohnston, and Jay E. Brenman
393 Molecular dissection of the myelin-associated glycoprotein receptor complex reveals cell type-specific mechanisms for neurite outgrowth inhibition Karthik Venkatesh, Onanong Chivatakarn, Shey-Shing Sheu, and Roman J. Giger
Articles 401 DNA methylation affects nuclear organization, histone modifications,
and linker histone binding but not chromatin compaction Nick Gilbert, Inga Thomson, Shelagh Boyle, James Allan, Bernard Ramsahoye, and Wendy A. Bickmore
413 Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments Haomin Huang, Jie Feng, Jakub Famulski, Jerome B. Rattner, Song Tao Liu, Gary D. Kao, Ruth Muschel, Gordon K.T. Chan, and TimJ. Yen
425 Emil is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C Barbara Di Fiore and Jonathon Pines
439 Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death Sylwia Wasiak, Rodolfo Zunino, and Heidi M. McBride
I I HaI THE J OYm11TOI I' TI I FuI CEL L BI [LO GYIc
On the cover Bones of the wrist are misshapen, dislocated, and partially fused in absence of Hif-1 o~. See page 451.
Articles with related stories in the IN THIS ISSUE section have page numbers in RED.
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Announcing Upcoming Keystone Symposia SEPTEMBER 2007 * The Transient Receptor Potential ion Channel Superfamily OCTOBER 2007 * Challenges of Global Vaccine Development * Frontiers in Gastrointestinal Cancer:
Molecular Genetics, Inflammation, Early Detection and Therapy JANUARY 2008 * Frontiers of Structural Biology * Structural Genomics and Its Applications to Chemistry,
Biology and Medicine * Eicosanoids and Other Mediators of Chronic Inflammation * Molecular Basis for Biological Membrane Organization * Forkhead Transcription Factor Networks in Development, Signaling, and Disease
* Pathological and Physiological Regulation of Cardiac Hypertrophy * Chemokines and Chemokine Receptors * Leukocyte Trafficking * Molecular Mechanisms of Angiogenesis in Development and Disease * Molecular, Cellular, Physiological, and Pathogenic Responses to Hypoxia
* Viral Immunity * Diabetes Mellitus, Insulin Action and Resistance * Translational Regulatory Mechanisms * Tolerance in Transplantation and Autoimmunity FEBRUARY 2008 * Biomarker Discovery, Validation and Applications * TGF-B Family in Homeostasis and Disease * Lymphocyte Activation and Signaling * Regulatory Mechanisms in Eukaryotic Transcription * Cell Death in the Immune System * Cell Death and Cellular Senescence * DNA Replication and Recombination * Plant Hormones and Signaling * Plant Innate Immunity * NF-kB * Cell Migration in Invasion and Inflammation * Wnt/b-Catenin Signaling in Development and Disease
* Cancer Genomics and Epigenomics * Molecular Control of Adipogenesis and Obesity * Neuronal Mechanisms Controlling Food Intake, Glucose Metabolism and Body Weight
* Towards Identifying the Pathophysiology of Autistic Syndromes * Tumor Suppressors and Stem Cell Biology * NK and NKT Cell Biology * Innate Immunity: Signaling Mechanisms * Complex Traits: Biologic and Therapeutic Insights MARCH 2008 * Genetics and Biochemistry of Sleep * Signaling Pathways in Cancer and Development * Alzheimer's Disease * RNAi, MicroRNA, and Non-Coding RNA * HIV Vaccines: Progress and Prospects * HIV Pathogenesis * Computer-Aided Drug Design * Inflammation, Microenvironment and Cancer * Nuclear Receptors: Orphan Brothers * Nuclear Receptors: Steroid Sisters * Metabolic Pathways of Longevity APRIL 2008 * Islet and Beta-Cell Biology * Islet and Beta Cell Development and Transplantation * Molecular Basis for Chromatin Modifications
and Epigenetic Phenomena * Molecular Evolution as a Driving Force in Infectious Diseases * Cell Biology of Virus Entry, Replication and Pathogenesis MAY 2008 * Translating New Technologies to Improve Public Health in Africa * G Protein-Coupled Receptors: New Insights in Functional Regulation and Clinical Application
JUNE 2008 * Malaria: Immunology, Pathogenesis and Vaccine Perspectives
For More Information, Please Visit www.keystonesymposia.org
Keystone Symposia 221 Summit Place #272, PO Box 1630 * Silverthorne, CO 80498
www.keystonesymposia.org * 800-253-0685 * 970-262-1230 Keystone Symposia on Molecular and Cellular Biology. a 501(c)(3) Nonprofit Organization
Directed and Supported by The Scientific Community
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451 Hif-la regulates differentiation of limb bud mesenchyme and joint development Sylvain Provot, Dawn Zinyk, Yasemin Gunes, Richa Kathri, Quynh Le, Henry M. Kronenberg, Randall S. Johnson, Michael T. Longaker, Amato J. Giaccia, and Ernestina Schipani
465 Cofilin promotes stimulus-induced lamellipodium formation by generating an abundant supply of actin monomers Tai Kiuchi, Kazumasa Ohashi, Souichi Kurita, and Kensaku Mizuno
477 v-SNARE cellubrevin is required for basolateral sorting of AP-1B-dependent cargo in polarized epithelial cells lan C. Fields, Elina Shteyn, Marc Pypaert, V6ronique Proux-Gillardeaux, Richard S. Kang, Thierry Galli, and Heike F61sch
489 Vascular endothelial growth factor can signal through platelet-derived growth factor receptors Stephen G. Ball, C. Adrian Shuttleworth, and Cay M. Kielty
501 Integrin-linked kinase is required for epidermal and hair follicle morphogenesis Katrin Lorenz, Carsten Grashoff, Robert Torka, Takao Sakai, Lutz Langbein, Wilhelm Bloch, Monique Aumailley, and Reinhard Fassler
515 oavP3 and ao5pl3 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration Dominic P. White, Patrick T. Caswell, and Jim C. Norman
527 Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix Mark D. Bass, Kirsty A. Roach, Mark R. Morgan, Zohreh Mostafavi-Pour, Tobias Schoen, Takashi Muramatsu, Ulrike Mayer, Christoph Ballestrem, Joachim P. Spatz, and Martin J. Humphries
539 Genetic alteration of endothelial heparan sulfate selectively inhibits tumor angiogenesis Mark M. Fuster, Lianchun Wang, Janice Castagnola, Lyudmila Sikora, Krisanavane Reddi, Phillip H.A. Lee, Katherine A. Radek, Manuela Schuksz, Joseph R. Bishop, Richard L. Gallo, P. Sriramarao, and Jeffrey D. Esko
551 Secreted gliomedin is a perinodal matrix component of peripheral nerves Yael Eshed, Konstantin Feinberg, David J. Carey, and Elior Peles
Retraction 563 FOXOla acts as a selective tumor suppressor
in alveolar rhabdomyosarcoma Philippe RJ. Bois, Kamel Izeradjene, PeterJ. Houghton, John L. Cleveland, Janet A. Houghton, and Gerard C. Grosveldz
SL5 Nucleotide Sit
Switch I L8 Switch II
Helix
Cryo-EM reconstructions of kinesin- decorated microtubules in the absence of nucleotide suggest that the switch I helix helps to eject ADP when kinesin initially binds to the filament. See page 377.
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Cytokines in Health and Disease 15TH INTERNATIONAL CONFERENCE ON CYTOKINES
The International Cytokine Society
October 26430, 2007
Hyatt Regency San Francisco San Francisco, California, USA
www.cytokines2 007.org
Deadline for Abstracts - June 11, 2007
Scientific Organizers Stephen Smale Richard A. Flavell HHMI UCLA HHMI Yale University
Christopher Hunter Abul Abbas University of Pennsylvania UCSF
Laurie Glimcher Harvard University
Confirmed Speakers Jeffrey Bluestone, Jean-Laurent Casanova, Robert Coffman, Daniel Cua, Vishva Dixit,
Sankar Ghosh, Charles Dinarello, Lionel Ivashkiv, Rob Kastelein, Vijay Kuchroo, Antonio Lanzavecchia, Warren Leonard, Foo Y. Liew, Dan Littman, Richard Locksley, Alberto Mantovani, Ruslan Medzhitov,
David Mosser, Peter Murray, Anne O'Garra, Luke O'Neill, John O'Shea, Keiko Ozato, William Paul, Fiona Powrie, Anjana Rao, David Raulet, Steven Reiner, Ellen Rothenberg, Alexander Rudensky,
Federica Sallusto, Robert Schreiber, Alan Sher, John Sims, Brigitta Stockinger, Tadatsugu Taniguchi, Giorgio Trinchieri, Jurg Tschopp, Carl Ware, Casey Weaver
Session Topics Th17 Responses in Host Defense, Autoimmunity and Cancer
Innate Recognition and Response T Cell Subsets
Cytokines, Chemokines, and Inflammation Inhibitory Receptors and Cytokines
Gene Regulation Inflammation and Cancer
Signal Transduction Regulation of Macrophage Activities and Responses
Clinical Progress
For more details on registration, abstracts, topics, hotel information, etc. visit us at www.cytokines2007.org
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Editor-in-Chief: Ira Mellman Yale University, New Haven, CT USA
he original international journal dedicated to cell biology, the Journal of Cell Biology, continues to
provide a rigorous forum for all the important topics in contemporary cell biological research. The JCB is one of the leading life sciences journals, with a high impact factor of 10.951* and a citation half-life of 7.7 years*. The JCB is a not-for-profit journal published by scientists that offers a free archive of full-text, searchable PDF versions of all articles dating back to 1955 (volume 1, issue 1).
JCB Online features: * Better searching: Instantly search the abstracts
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Cell Culture Tip #5
Media matters!
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