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Full Automation, True Random Access For IHC and ISH Tissue-Tek Genie ® Advanced Staining System continuous innovation for pathology
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Full Automation, True Random Access For IHC and ISH

Tissue-Tek Genie®

Advanced Staining System

continuous innovation for pathology

Tissue-Tek Genie Brochure Jan2017 Update.indd 1 1/29/2017 8:42:22 PM

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Page is color controlled with Prinect Printready ColorCarver 15.00.046 Copyright 2014 Heidelberger Druckmaschinen AG http://www.heidelberg.com You can view actual document colors and color spaces, with the free Color Editor (Viewer), a Plug-In from the Prinect PDF Toolbox. Please request a PDF Toolbox CD from your local Heidelberg office in order to install it on your computer. Applied Color Management Settings: Output Intent (Press Profile): GRACoL2006_Coated1v2.icc RGB Image: Profile: AdobeRGB1998.icc Rendering Intent: Perceptual Black Point Compensation: no RGB Graphic: Profile: AdobeRGB1998.icc Rendering Intent: Perceptual Black Point Compensation: no Device Independent RGB/Lab Image: Rendering Intent: Perceptual Black Point Compensation: no Device Independent RGB/Lab Graphic: Rendering Intent: Perceptual Black Point Compensation: no Device Independent CMYK/Gray Image: Rendering Intent: Perceptual Black Point Compensation: no Device Independent CMYK/Gray Graphic: Rendering Intent: Perceptual Black Point Compensation: no Turn R=G=B (Tolerance 0.5%) Graphic into Gray: yes Turn C=M=Y,K=0 (Tolerance 0.5%) Graphic into Gray: yes CMM for overprinting CMYK graphic: no Gray Image: Apply CMYK Profile: no Gray Graphic: Apply CMYK Profile: no Treat Calibrated RGB as Device RGB: no Treat Calibrated Gray as Device Gray: yes Remove embedded non-CMYK Profiles: yes Remove embedded CMYK Profiles: yes Applied Miscellaneous Settings: Colors to knockout: no Gray to knockout: no Pure black to overprint: no Turn Overprint CMYK White to Knockout: yes Turn Overprinting Device Gray to K: yes CMYK Overprint mode: set to OPM1 if not set Create "All" from 4x100% CMYK: yes Delete "All" Colors: no Convert "All" to K: no

Predictable Speed with Maximum Flexibility

Introducing the Tissue-Tek Genie Advanced Staining System: the first and only fully automated, true random access stainer for IHC and ISH featuring 30 completely independent slide stations for uncompromised fast and predictable TAT with 5 antibody and probe dispensing options for unprecedented staining quality.

Online, remote diagnostic monitoring using Tissue-Tek® iSupport™

Easy-to-learn and simple-to-operate User Interface

Carousel with peristaltic pump for high volume reagent, antibody, and probe Cartridge dispensing

Single-use Capsules for high or low volume dispensing of antibodies and probes

30 completely independent slide stations

Bottles for separating non-hazardous from hazardous waste with weight scales

On-board bulk bottles with

weight scales

LEDs to indicate independent slide station

status

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Tissue-Tek Genie Brochure Jan2017 Update.indd 2 1/29/2017 8:42:25 PM

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Page is color controlled with Prinect Printready ColorCarver 15.00.046 Copyright 2014 Heidelberger Druckmaschinen AG http://www.heidelberg.com You can view actual document colors and color spaces, with the free Color Editor (Viewer), a Plug-In from the Prinect PDF Toolbox. Please request a PDF Toolbox CD from your local Heidelberg office in order to install it on your computer. Applied Color Management Settings: Output Intent (Press Profile): GRACoL2006_Coated1v2.icc RGB Image: Profile: AdobeRGB1998.icc Rendering Intent: Perceptual Black Point Compensation: no RGB Graphic: Profile: AdobeRGB1998.icc Rendering Intent: Perceptual Black Point Compensation: no Device Independent RGB/Lab Image: Rendering Intent: Perceptual Black Point Compensation: no Device Independent RGB/Lab Graphic: Rendering Intent: Perceptual Black Point Compensation: no Device Independent CMYK/Gray Image: Rendering Intent: Perceptual Black Point Compensation: no Device Independent CMYK/Gray Graphic: Rendering Intent: Perceptual Black Point Compensation: no Turn R=G=B (Tolerance 0.5%) Graphic into Gray: yes Turn C=M=Y,K=0 (Tolerance 0.5%) Graphic into Gray: yes CMM for overprinting CMYK graphic: no Gray Image: Apply CMYK Profile: no Gray Graphic: Apply CMYK Profile: no Treat Calibrated RGB as Device RGB: no Treat Calibrated Gray as Device Gray: yes Remove embedded non-CMYK Profiles: yes Remove embedded CMYK Profiles: yes Applied Miscellaneous Settings: Colors to knockout: no Gray to knockout: no Pure black to overprint: no Turn Overprint CMYK White to Knockout: yes Turn Overprinting Device Gray to K: yes CMYK Overprint mode: set to OPM1 if not set Create "All" from 4x100% CMYK: yes Delete "All" Colors: no Convert "All" to K: no

Key Features

30 completely independent slide stations, true random access, and predictable TAT

5 antibody and probe dispensing options, high on-board capacity

Proven Sakura reliability with minimal maintenance

Convenient, Safe, and Economical

1 2 3 4

Ability to run 30 different protocols simultaneously without compromising TAT for any slide

Single slide loading or unloading for LEAN, batch-free staining

Walkaway automation (from Dewaxing through Counterstaining)

Unique Advanced Gap Technology for optimized whole slide coverage

Open protocol setup for user-defined antibodies

Fast and predictable TAT for IHC, delivering same- day case management

Wide range of Ready-to-Use (RTU) antibodies and probes with predefined optimized protocols

Single-use RTU Capsules for high or low volume antibodies or probes

250-use RTU Cartridges for high volume antibodies or probes

User-Fillable Capsules or Cartridges available for antibodies or probes

Manual pipetting for quick antibody or probe titrations

Total on-board capacity for up to 42 different antibodies or probes

Mean time between repairs exceeds 52 weeks

On-board mixing of chromogen and substrate just-in-time

Online, remote diagnostic monitoring using Tissue-Tek iSupport

No aspirating or dispensing probes to clean

Weight scales for monitoring bulk reagents

Full-service support network of professional and experienced application specialists and service engineers

Minimum daily setup time

One gallon bottles for convenient strain-free handling

On-board, easily accessible bulk reagent storage

Separation of non-hazardous from hazardous waste

Low total volume waste generation

Weight scales for monitoring waste generation

Substantial savings in waste disposal

Tissue-Tek Genie®

3

Tissue-Tek Genie Brochure Jan2017 Update.indd 3 1/29/2017 8:42:28 PM

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Page is color controlled with Prinect Printready ColorCarver 15.00.046 Copyright 2014 Heidelberger Druckmaschinen AG http://www.heidelberg.com You can view actual document colors and color spaces, with the free Color Editor (Viewer), a Plug-In from the Prinect PDF Toolbox. Please request a PDF Toolbox CD from your local Heidelberg office in order to install it on your computer. Applied Color Management Settings: Output Intent (Press Profile): GRACoL2006_Coated1v2.icc RGB Image: Profile: AdobeRGB1998.icc Rendering Intent: Perceptual Black Point Compensation: no RGB Graphic: Profile: AdobeRGB1998.icc Rendering Intent: Perceptual Black Point Compensation: no Device Independent RGB/Lab Image: Rendering Intent: Perceptual Black Point Compensation: no Device Independent RGB/Lab Graphic: Rendering Intent: Perceptual Black Point Compensation: no Device Independent CMYK/Gray Image: Rendering Intent: Perceptual Black Point Compensation: no Device Independent CMYK/Gray Graphic: Rendering Intent: Perceptual Black Point Compensation: no Turn R=G=B (Tolerance 0.5%) Graphic into Gray: yes Turn C=M=Y,K=0 (Tolerance 0.5%) Graphic into Gray: yes CMM for overprinting CMYK graphic: no Gray Image: Apply CMYK Profile: no Gray Graphic: Apply CMYK Profile: no Treat Calibrated RGB as Device RGB: no Treat Calibrated Gray as Device Gray: yes Remove embedded non-CMYK Profiles: yes Remove embedded CMYK Profiles: yes Applied Miscellaneous Settings: Colors to knockout: no Gray to knockout: no Pure black to overprint: no Turn Overprint CMYK White to Knockout: yes Turn Overprinting Device Gray to K: yes CMYK Overprint mode: set to OPM1 if not set Create "All" from 4x100% CMYK: yes Delete "All" Colors: no Convert "All" to K: no

Tissue-Tek Genie®

Predictable TAT with True Random AccessScheduler-free, single slide staining operations

Accommodates STAT specimens for expedited processing without impacting other slides

Efficient, LEAN slide management to ensure predictabledelivery time to Pathologists

True Walkaway Automation 30 completely independent slide stations to handle 30slides with up to 30 different protocols simultaneously

Easy, single slide loading and unloading for batch-free operation

Ability to run IHC and ISH simultaneously without prolonging TAT

LEAN, Efficient, Optimized WorkflowSingle piece (slide) workflow, eliminates the wait timeto group slides

No unused slide positions; no need for slide trays; no need to match slide protocols

Ability to stain individual slides or entire cases simultaneously

Run STAT or add-on slides without affecting otherrunning slides

Flexibility to load and unload slides without impactingworkflow and TAT

Run IHC and ISH simultaneously for case-centric, same- day delivery

Responsive to changes in workflow

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Tissue-Tek Genie Brochure Jan2017 Update.indd 4 1/29/2017 8:42:29 PM

Prinect Printready ColorCarver
Page is color controlled with Prinect Printready ColorCarver 15.00.046 Copyright 2014 Heidelberger Druckmaschinen AG http://www.heidelberg.com You can view actual document colors and color spaces, with the free Color Editor (Viewer), a Plug-In from the Prinect PDF Toolbox. Please request a PDF Toolbox CD from your local Heidelberg office in order to install it on your computer. Applied Color Management Settings: Output Intent (Press Profile): GRACoL2006_Coated1v2.icc RGB Image: Profile: AdobeRGB1998.icc Rendering Intent: Perceptual Black Point Compensation: no RGB Graphic: Profile: AdobeRGB1998.icc Rendering Intent: Perceptual Black Point Compensation: no Device Independent RGB/Lab Image: Rendering Intent: Perceptual Black Point Compensation: no Device Independent RGB/Lab Graphic: Rendering Intent: Perceptual Black Point Compensation: no Device Independent CMYK/Gray Image: Rendering Intent: Perceptual Black Point Compensation: no Device Independent CMYK/Gray Graphic: Rendering Intent: Perceptual Black Point Compensation: no Turn R=G=B (Tolerance 0.5%) Graphic into Gray: yes Turn C=M=Y,K=0 (Tolerance 0.5%) Graphic into Gray: yes CMM for overprinting CMYK graphic: no Gray Image: Apply CMYK Profile: no Gray Graphic: Apply CMYK Profile: no Treat Calibrated RGB as Device RGB: no Treat Calibrated Gray as Device Gray: yes Remove embedded non-CMYK Profiles: yes Remove embedded CMYK Profiles: yes Applied Miscellaneous Settings: Colors to knockout: no Gray to knockout: no Pure black to overprint: no Turn Overprint CMYK White to Knockout: yes Turn Overprinting Device Gray to K: yes CMYK Overprint mode: set to OPM1 if not set Create "All" from 4x100% CMYK: yes Delete "All" Colors: no Convert "All" to K: no

System and Slide Status at a GlanceFast-to-learn and easy-to-operate user interface

Graphics and icons for visual management of system and slide status at a glance

Visual and audio alerts to notify user that system interaction is required

User interface provides customizable process control and traceability

Uniform, Reproducible Staining, FullSlide CoverageSakura’s Advanced Gap Technology allows uniform full slide coverage, eliminates “rail” artifacts, and allows tissue sections to be placed anywhere on the slide

Innovative, rapid, optimized reagent exchange in the Gap reduces TAT and eliminates drying artifacts

Fine-tuned, asymmetric Gap design optimized for fast and complete liquid exchange, reducing time and waste production

Eliminates purchasing or washing tiles or coverlids, or using oily-reagents to limit evaporation

Improved Staining withReduced BackgroundEach individual slide station has a built-in temperaturecontrolling system for fast and efficient temperature changes

The Peltier elements unprecedented fast heating and “ACTIVE fast cooling” for shorter incubation times and reduced background

Direct heating and cooling of reagents (not slides) for shortest response time to temperature changes with no risk of overheating tissue or sensitive reagents

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Tissue-Tek Genie®

Tissue-Tek Genie Brochure Jan2017 Update.indd 5 1/29/2017 8:42:31 PM

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Page is color controlled with Prinect Printready ColorCarver 15.00.046 Copyright 2014 Heidelberger Druckmaschinen AG http://www.heidelberg.com You can view actual document colors and color spaces, with the free Color Editor (Viewer), a Plug-In from the Prinect PDF Toolbox. Please request a PDF Toolbox CD from your local Heidelberg office in order to install it on your computer. Applied Color Management Settings: Output Intent (Press Profile): GRACoL2006_Coated1v2.icc RGB Image: Profile: AdobeRGB1998.icc Rendering Intent: Perceptual Black Point Compensation: no RGB Graphic: Profile: AdobeRGB1998.icc Rendering Intent: Perceptual Black Point Compensation: no Device Independent RGB/Lab Image: Rendering Intent: Perceptual Black Point Compensation: no Device Independent RGB/Lab Graphic: Rendering Intent: Perceptual Black Point Compensation: no Device Independent CMYK/Gray Image: Rendering Intent: Perceptual Black Point Compensation: no Device Independent CMYK/Gray Graphic: Rendering Intent: Perceptual Black Point Compensation: no Turn R=G=B (Tolerance 0.5%) Graphic into Gray: yes Turn C=M=Y,K=0 (Tolerance 0.5%) Graphic into Gray: yes CMM for overprinting CMYK graphic: no Gray Image: Apply CMYK Profile: no Gray Graphic: Apply CMYK Profile: no Treat Calibrated RGB as Device RGB: no Treat Calibrated Gray as Device Gray: yes Remove embedded non-CMYK Profiles: yes Remove embedded CMYK Profiles: yes Applied Miscellaneous Settings: Colors to knockout: no Gray to knockout: no Pure black to overprint: no Turn Overprint CMYK White to Knockout: yes Turn Overprinting Device Gray to K: yes CMYK Overprint mode: set to OPM1 if not set Create "All" from 4x100% CMYK: yes Delete "All" Colors: no Convert "All" to K: no

Cost Saving RTU Capsule Packaging Optimizes WorkflowExclusive, single-use Capsule allows flexible continuous automation for both high-and low-volume antibodies or probes

Efficient Capsule packaging for cost saving by preventing waste from expired antibodies and probes

RTU antibodies and probes reduce human errors and save preparation time by eliminating dilution, mixing, and titration

Capsules eliminate the disruption of manually adding antibodies or probes

Flexibility of Using User-Fillable Empty Capsules Empty, User-Fillable Capsules are available for user-defined antibodies and probes

User-Fillable Capsules can be loaded onto Tissue-Tek Genie for walkaway automation

Capsule Filling Block available for preparing User-Fillable Capsules

Progesterone Receptor Expression

Tissue-Tek Genie®

6

Tissue-Tek Genie Brochure Jan2017 Update.indd 6 1/29/2017 8:42:31 PM

Prinect Printready ColorCarver
Page is color controlled with Prinect Printready ColorCarver 15.00.046 Copyright 2014 Heidelberger Druckmaschinen AG http://www.heidelberg.com You can view actual document colors and color spaces, with the free Color Editor (Viewer), a Plug-In from the Prinect PDF Toolbox. Please request a PDF Toolbox CD from your local Heidelberg office in order to install it on your computer. Applied Color Management Settings: Output Intent (Press Profile): GRACoL2006_Coated1v2.icc RGB Image: Profile: AdobeRGB1998.icc Rendering Intent: Perceptual Black Point Compensation: no RGB Graphic: Profile: AdobeRGB1998.icc Rendering Intent: Perceptual Black Point Compensation: no Device Independent RGB/Lab Image: Rendering Intent: Perceptual Black Point Compensation: no Device Independent RGB/Lab Graphic: Rendering Intent: Perceptual Black Point Compensation: no Device Independent CMYK/Gray Image: Rendering Intent: Perceptual Black Point Compensation: no Device Independent CMYK/Gray Graphic: Rendering Intent: Perceptual Black Point Compensation: no Turn R=G=B (Tolerance 0.5%) Graphic into Gray: yes Turn C=M=Y,K=0 (Tolerance 0.5%) Graphic into Gray: yes CMM for overprinting CMYK graphic: no Gray Image: Apply CMYK Profile: no Gray Graphic: Apply CMYK Profile: no Treat Calibrated RGB as Device RGB: no Treat Calibrated Gray as Device Gray: yes Remove embedded non-CMYK Profiles: yes Remove embedded CMYK Profiles: yes Applied Miscellaneous Settings: Colors to knockout: no Gray to knockout: no Pure black to overprint: no Turn Overprint CMYK White to Knockout: yes Turn Overprinting Device Gray to K: yes CMYK Overprint mode: set to OPM1 if not set Create "All" from 4x100% CMYK: yes Delete "All" Colors: no Convert "All" to K: no

No Reagent Carryover UsingCartridge Dispenser Novel peristaltic Cartridge dispense mechanism ensures no carryover and consistent reagent common with syringe dispensing

Peristaltic Cartridge dispense action ensures accurate, precise volume delivery through dispense funnels

Cartridge dispense design eliminates the need and time to clean syringes and lines

Comprehensive Test Menu, OpenAntibodies, and ProbesWide range of Tissue-Tek Genie antibodies and probes provided in two RTU formats

Tissue-Tek Genie RTU antibodies, probes and ancillary reagents with pre-defined and optimized protocols ensure reproducible and standardized results

The Tissue-Tek Genie platform is open to allow user-defined antibodies and probes with flexible protocol setup

No Reagent Carryover UsingCapsule DispenserInnovative Capsule piercing system eliminates any reagent carryover seen with syringe dispensing

Double plunging Capsule dispensing technology ensures accurate, precise volume delivery through dispense funnels

Capsule dispense design eliminates the need and time to clean syringes and lines

7

Tissue-Tek Genie®

Tissue-Tek Genie Brochure Jan2017 Update.indd 7 1/29/2017 8:42:32 PM

Prinect Printready ColorCarver
Page is color controlled with Prinect Printready ColorCarver 15.00.046 Copyright 2014 Heidelberger Druckmaschinen AG http://www.heidelberg.com You can view actual document colors and color spaces, with the free Color Editor (Viewer), a Plug-In from the Prinect PDF Toolbox. Please request a PDF Toolbox CD from your local Heidelberg office in order to install it on your computer. Applied Color Management Settings: Output Intent (Press Profile): GRACoL2006_Coated1v2.icc RGB Image: Profile: AdobeRGB1998.icc Rendering Intent: Perceptual Black Point Compensation: no RGB Graphic: Profile: AdobeRGB1998.icc Rendering Intent: Perceptual Black Point Compensation: no Device Independent RGB/Lab Image: Rendering Intent: Perceptual Black Point Compensation: no Device Independent RGB/Lab Graphic: Rendering Intent: Perceptual Black Point Compensation: no Device Independent CMYK/Gray Image: Rendering Intent: Perceptual Black Point Compensation: no Device Independent CMYK/Gray Graphic: Rendering Intent: Perceptual Black Point Compensation: no Turn R=G=B (Tolerance 0.5%) Graphic into Gray: yes Turn C=M=Y,K=0 (Tolerance 0.5%) Graphic into Gray: yes CMM for overprinting CMYK graphic: no Gray Image: Apply CMYK Profile: no Gray Graphic: Apply CMYK Profile: no Treat Calibrated RGB as Device RGB: no Treat Calibrated Gray as Device Gray: yes Remove embedded non-CMYK Profiles: yes Remove embedded CMYK Profiles: yes Applied Miscellaneous Settings: Colors to knockout: no Gray to knockout: no Pure black to overprint: no Turn Overprint CMYK White to Knockout: yes Turn Overprinting Device Gray to K: yes CMYK Overprint mode: set to OPM1 if not set Create "All" from 4x100% CMYK: yes Delete "All" Colors: no Convert "All" to K: no

Flexibility of Using Empty Refillable CartridgesEmpty, User-Fillable Cartridges are available for user-defined antibodies and probes

User-Fillable Cartridges can be loaded onto Tissue-Tek Genie for walkaway automation

Empty Cartridges can be refilled up to 4 times

Economical RTU Cartridge Packaging Optimizes Workflow 250-use Cartridges for high volume antibodies or probes for maximal cost effectiveness

RTU reagents reduce human errors and save preparation time by eliminating dilution, mixing and titration

RTU ensures reproducible and high quality staining for advancing standardization

High Quality Detection ChemistryFast and clean polymer system for use in both IHC and ISH

Optimized for Tissue-Tek Genie Advanced Staining System to obtain definitive staining results

High specificity for maximal signal-to-noise ratio facilitating fast slide review

High sensitivity for amplification of low expression targets using mouse and rabbit antibodies

Biotin-free detection system reduces endogenous background

Small, multi-functional linkers enhance tissue penetration

Dual Cartridge dispensing format ensures on-board, fresh chromogen mixing

Tissue-Tek Genie®

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Tissue-Tek Genie Brochure Jan2017 Update.indd 8 1/29/2017 8:42:34 PM

Prinect Printready ColorCarver
Page is color controlled with Prinect Printready ColorCarver 15.00.046 Copyright 2014 Heidelberger Druckmaschinen AG http://www.heidelberg.com You can view actual document colors and color spaces, with the free Color Editor (Viewer), a Plug-In from the Prinect PDF Toolbox. Please request a PDF Toolbox CD from your local Heidelberg office in order to install it on your computer. Applied Color Management Settings: Output Intent (Press Profile): GRACoL2006_Coated1v2.icc RGB Image: Profile: AdobeRGB1998.icc Rendering Intent: Perceptual Black Point Compensation: no RGB Graphic: Profile: AdobeRGB1998.icc Rendering Intent: Perceptual Black Point Compensation: no Device Independent RGB/Lab Image: Rendering Intent: Perceptual Black Point Compensation: no Device Independent RGB/Lab Graphic: Rendering Intent: Perceptual Black Point Compensation: no Device Independent CMYK/Gray Image: Rendering Intent: Perceptual Black Point Compensation: no Device Independent CMYK/Gray Graphic: Rendering Intent: Perceptual Black Point Compensation: no Turn R=G=B (Tolerance 0.5%) Graphic into Gray: yes Turn C=M=Y,K=0 (Tolerance 0.5%) Graphic into Gray: yes CMM for overprinting CMYK graphic: no Gray Image: Apply CMYK Profile: no Gray Graphic: Apply CMYK Profile: no Treat Calibrated RGB as Device RGB: no Treat Calibrated Gray as Device Gray: yes Remove embedded non-CMYK Profiles: yes Remove embedded CMYK Profiles: yes Applied Miscellaneous Settings: Colors to knockout: no Gray to knockout: no Pure black to overprint: no Turn Overprint CMYK White to Knockout: yes Turn Overprinting Device Gray to K: yes CMYK Overprint mode: set to OPM1 if not set Create "All" from 4x100% CMYK: yes Delete "All" Colors: no Convert "All" to K: no

Maximize Uptime with Tissue-Tek iSupportSakura Tissue-Tek iSupport ensures continuous online, remote monitoring of the Tissue-Tek Genie Advanced Staining System, components and functions, thus providing less downtime and increased productivity

The latest in advanced remote diagnostics and monitoring technology for efficient and secure communication

Faster remote interventions and on-site repairs, providing the right tools for the correct solution

Minimize downtime, maximize system uptime

Sakura’s Predictable Product ReliabilityWorld-renowned Japanese design, engineering and manufacturing

Minimal system maintenance for high uptime

Professional and highly-trained applications support

Factory trained, experienced service engineers

Industry-leading in overall customer satisfaction

Cost-Efficient Waste Management User-defined separation of hazardous from non-hazardous waste

Very low volume waste generation minimizes user interaction to only once per day

Low waste generation reduces costs for hazard waste disposal

One gallon bottles for convenient, strain-free handling

Minimal hands-on daily maintenance

9

Tissue-Tek Genie®

Tissue-Tek Genie Brochure Jan2017 Update.indd 9 1/29/2017 8:42:36 PM

Prinect Printready ColorCarver
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Product Name Tissue-Tek Genie® Advanced Staining System

Item Codes 8201 (115VAC, 20A for USA)8202 (230VAC, 15A for Europe and Latin America)

ApplicationsAutomated IHC and ISH, Dewaxing, Antigen Retrieval, Rehydration, Digestion, Denaturation, Hybridization, Stringent Wash, Staining, Counterstaining

Turn-Around Time 1 hour 44 minutes to 2 hours 44 minutes IHC including dewaxing, antigen retrieval to counterstaining

Throughput Up to 90 IHC slides in 8 hours

Temperature Control of Reagent on Slides 50°F to 208°F (10°C to 98°C)

Slide Capacity 30 independent slide stations

Slide Requirements 1 x 3 in., 25 x 75 mm or 26 x 76 mm Positively Charged Slides

Modularity Up to 5 Tissue-Tek Genie instruments may be controlled from 1 PC

Configuration Free standing, floor model

User Access Levels 3, user-defined

Water Supply Not required

Dimensions W x D x H: 65 x 30 x 63 in. (165 x 75 x 160 cm)

Weight (Dry) 1,280 lbs. (580 kg)

Instrument Operating Conditions

Temperature Range: 59°F to 86°F (15°C to 30°C)

Relative Humidity Range 30 ~ 80% R.H., Non-Condensing

Noise Level <65 dB (Operating) at 3 ft. (1 m)

General Instrument Specifications

Physical Specifications

Environmental Specifications

Specifications

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Tissue-Tek Genie Brochure Jan2017 Update.indd 10 1/29/2017 8:42:36 PM

Prinect Printready ColorCarver
Page is color controlled with Prinect Printready ColorCarver 15.00.046 Copyright 2014 Heidelberger Druckmaschinen AG http://www.heidelberg.com You can view actual document colors and color spaces, with the free Color Editor (Viewer), a Plug-In from the Prinect PDF Toolbox. Please request a PDF Toolbox CD from your local Heidelberg office in order to install it on your computer. Applied Color Management Settings: Output Intent (Press Profile): GRACoL2006_Coated1v2.icc RGB Image: Profile: AdobeRGB1998.icc Rendering Intent: Perceptual Black Point Compensation: no RGB Graphic: Profile: AdobeRGB1998.icc Rendering Intent: Perceptual Black Point Compensation: no Device Independent RGB/Lab Image: Rendering Intent: Perceptual Black Point Compensation: no Device Independent RGB/Lab Graphic: Rendering Intent: Perceptual Black Point Compensation: no Device Independent CMYK/Gray Image: Rendering Intent: Perceptual Black Point Compensation: no Device Independent CMYK/Gray Graphic: Rendering Intent: Perceptual Black Point Compensation: no Turn R=G=B (Tolerance 0.5%) Graphic into Gray: yes Turn C=M=Y,K=0 (Tolerance 0.5%) Graphic into Gray: yes CMM for overprinting CMYK graphic: no Gray Image: Apply CMYK Profile: no Gray Graphic: Apply CMYK Profile: no Treat Calibrated RGB as Device RGB: no Treat Calibrated Gray as Device Gray: yes Remove embedded non-CMYK Profiles: yes Remove embedded CMYK Profiles: yes Applied Miscellaneous Settings: Colors to knockout: no Gray to knockout: no Pure black to overprint: no Turn Overprint CMYK White to Knockout: yes Turn Overprinting Device Gray to K: yes CMYK Overprint mode: set to OPM1 if not set Create "All" from 4x100% CMYK: yes Delete "All" Colors: no Convert "All" to K: no

IHC and ISH Menus See Sakura Advanced Staining Catalog

Capsule Capacity On-Board 30

Cartridge Capacity On-Board 19

Bulk Reagent Container Capacity 6 x 1 gallon

Bulk Waste Container Capacity 2 x 1 gallon

Antibody and ProbeDispensing Options

Prefilled RTU Capsules Prefilled RTU Cartridges User-Fillable Capsules User-Fillable CartridgesManual Pipetting

Power Required

115VAC ± 10%, 50/60Hz, Single phase, 20A;230VAC ± 10%, 50/60Hz, Single Phase, 15A

Power Rating

115VAC, 50/60Hz, Single phase, 18A;230VAC, 50/60Hz, Single Phase, 9A

Power Connection

Power Cord Suited to Country. For USA, Standard 3 Prong, Grounded

Interface USB; 1 port, Type B

Connectivity LIMS, LIS, Middleware

Barcode 1D (code 93) and 2D (Datamatrix, QR code)

Certifications ETL

Remote Diagnostics Basic Internet Connection

Control PC with Mouse, Keyboard, Monitor, and 2 Label Printers (1 printer for Tag Labels and 1 printer for Slide Labels)

Starter Kit (1 bottle Dewax Solution, 1 bottle Citrate Antigen Retrieval Solution, 1 bottle High pH Antigen Re-trieval Solution, 4 bottles Wash Buffer, 2 Waste bottles, 1 Cleaning bottle (with 1 tube adapter), 1 Water Rinse bottle, 90 RDA, 90 RDA-Tags, Slide Label Kit, RDA-Tag Label Kit)

Power Cable for the Stainer Module

USB 2.0 Cable 9 ft. (3 m)

Uninterrupted Power Supply (UPS)

8217 Tissue-Tek Genie® Waste Bottles, 3.8L; 4/Case

8616 Tissue-Tek Genie® Reagent Dispense Area (RDA); 90/Box

8618 Tissue-Tek Genie® Reagent Dispense Area Tag (RDA-Tag); 90/Box

8637Tissue-Tek Genie® RDA-Tag Label Kit; 1 Ribbon and 2 Rolls for 2,400 RDA-Tag Labels

8636 Tissue-Tek Genie® Slide Label Kit; 1 Ribbon and 3 Rolls for 3,000 Slide Labels

8622 Tissue-Tek Genie® Antibody Cartridge, User-Fillable; 6/Box

8624 Tissue-Tek Genie® Enzyme Cartridge, User-Fillable; 6/Box

Reagent Specifications

Electrical Specifications

Accessories

Consumables

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Tissue-Tek Genie®

Tissue-Tek Genie Brochure Jan2017 Update.indd 11 1/29/2017 8:42:36 PM

Prinect Printready ColorCarver
Page is color controlled with Prinect Printready ColorCarver 15.00.046 Copyright 2014 Heidelberger Druckmaschinen AG http://www.heidelberg.com You can view actual document colors and color spaces, with the free Color Editor (Viewer), a Plug-In from the Prinect PDF Toolbox. Please request a PDF Toolbox CD from your local Heidelberg office in order to install it on your computer. Applied Color Management Settings: Output Intent (Press Profile): GRACoL2006_Coated1v2.icc RGB Image: Profile: AdobeRGB1998.icc Rendering Intent: Perceptual Black Point Compensation: no RGB Graphic: Profile: AdobeRGB1998.icc Rendering Intent: Perceptual Black Point Compensation: no Device Independent RGB/Lab Image: Rendering Intent: Perceptual Black Point Compensation: no Device Independent RGB/Lab Graphic: Rendering Intent: Perceptual Black Point Compensation: no Device Independent CMYK/Gray Image: Rendering Intent: Perceptual Black Point Compensation: no Device Independent CMYK/Gray Graphic: Rendering Intent: Perceptual Black Point Compensation: no Turn R=G=B (Tolerance 0.5%) Graphic into Gray: yes Turn C=M=Y,K=0 (Tolerance 0.5%) Graphic into Gray: yes CMM for overprinting CMYK graphic: no Gray Image: Apply CMYK Profile: no Gray Graphic: Apply CMYK Profile: no Treat Calibrated RGB as Device RGB: no Treat Calibrated Gray as Device Gray: yes Remove embedded non-CMYK Profiles: yes Remove embedded CMYK Profiles: yes Applied Miscellaneous Settings: Colors to knockout: no Gray to knockout: no Pure black to overprint: no Turn Overprint CMYK White to Knockout: yes Turn Overprinting Device Gray to K: yes CMYK Overprint mode: set to OPM1 if not set Create "All" from 4x100% CMYK: yes Delete "All" Colors: no Convert "All" to K: no

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Sakura Finetek USA, Inc.1750 W. 214th StreetTorrance, CA 90501Phone (800) 725-8723

2016 Sakura Finetek USA, Inc.0007991-01 Rev. B

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Tissue-Tek Genie Brochure Jan2017 Update.indd 12 1/29/2017 8:42:36 PM

Prinect Printready ColorCarver
Page is color controlled with Prinect Printready ColorCarver 15.00.046 Copyright 2014 Heidelberger Druckmaschinen AG http://www.heidelberg.com You can view actual document colors and color spaces, with the free Color Editor (Viewer), a Plug-In from the Prinect PDF Toolbox. Please request a PDF Toolbox CD from your local Heidelberg office in order to install it on your computer. Applied Color Management Settings: Output Intent (Press Profile): GRACoL2006_Coated1v2.icc RGB Image: Profile: AdobeRGB1998.icc Rendering Intent: Perceptual Black Point Compensation: no RGB Graphic: Profile: AdobeRGB1998.icc Rendering Intent: Perceptual Black Point Compensation: no Device Independent RGB/Lab Image: Rendering Intent: Perceptual Black Point Compensation: no Device Independent RGB/Lab Graphic: Rendering Intent: Perceptual Black Point Compensation: no Device Independent CMYK/Gray Image: Rendering Intent: Perceptual Black Point Compensation: no Device Independent CMYK/Gray Graphic: Rendering Intent: Perceptual Black Point Compensation: no Turn R=G=B (Tolerance 0.5%) Graphic into Gray: yes Turn C=M=Y,K=0 (Tolerance 0.5%) Graphic into Gray: yes CMM for overprinting CMYK graphic: no Gray Image: Apply CMYK Profile: no Gray Graphic: Apply CMYK Profile: no Treat Calibrated RGB as Device RGB: no Treat Calibrated Gray as Device Gray: yes Remove embedded non-CMYK Profiles: yes Remove embedded CMYK Profiles: yes Applied Miscellaneous Settings: Colors to knockout: no Gray to knockout: no Pure black to overprint: no Turn Overprint CMYK White to Knockout: yes Turn Overprinting Device Gray to K: yes CMYK Overprint mode: set to OPM1 if not set Create "All" from 4x100% CMYK: yes Delete "All" Colors: no Convert "All" to K: no

Prinect PDF Report 15.00.046 - 1 - 01/30/2017 08:41:19 AM

Document overviewFile name: Tissue-Tek Genie Brochure Jan2017 Update.pdfTitle: -Creator: Adobe InDesign CC 2015 (Windows)Producer: Adobe PDF Library 15.0Author: -Creation Date: 01/29/2017 08:42:19 PMModification Date: 01/29/2017 08:42:36 PMFile size: 4.4 MByte / 4479.0 KByteTrapped: NoOutput Intent: -PDF/X Version: -PDF Version: 1.4Number of pages: 12Media Box: 9.32 x 11.82 inchTrim Box: 8.50 x 11.00 inch

Summary Error Warning Fixed InfoDocument - - - -PDF/X - - - -Pages - - - -Colors - 80 - -Fonts - 210 - 62Images - 25 - -Content - - - -

ColorsColor space: Device RGB #80 (1-12)

FontsHelveticaNeue: Character is not defined correctly #116 (2-12)HelveticaNeue-Bold: Character is not defined correctly #77 (1-12)HelveticaNeue-Light: Character is not defined correctly #17 (1-11)HelveticaNeue-Bold (5.2 pt) uses 2 separations #5 (3,5,7,9,11)HelveticaNeue-Bold (9.0 pt) uses 2 separations #5 (3,5,7,9,11)HelveticaNeue-Bold (9.9 pt) uses 2 separations #1 (1)HelveticaNeue-Bold (10.5 pt) uses 2 separations #3 (4,6,8)HelveticaNeue-Bold (12.0 pt) uses 2 separations #1 (1)HelveticaNeue-Bold (13.0 pt) uses 4 separations #35 (4-11)HelveticaNeue-Bold (17.0 pt) uses 2 separations #1 (1)HelveticaNeue-Bold (18.0 pt) uses 2 separations #5 (4,6,8,10,12)HelveticaNeue-Light (15.0 pt) uses 2 separations #3 (1)TimesTen-BoldItalic (13.0 pt) uses 4 separations #1 (9)

Prinect PDF Report 15.00.046 - 2 - 01/30/2017 08:41:19 AM

SchulbuchNord-Normal (11.0 pt) uses 4 separations #2 (1,12)Images

Color image resolution 168 dpi is below 300 dpi #1 (12)Color image resolution 211 dpi is below 300 dpi #1 (9)Color image resolution 258 dpi is below 300 dpi #1 (5)Images using lossy JPEG compression are present #22 (1-9,12)

Additional informationSettings used: Qualify_Offset

Color separations: 4CMYK

Color spacesDeviceCMYK / SeparationDeviceRGB

Fonts: 10Helvetica Type1 / WinAnsi / embedded subsetHelveticaNeue TrueType / WinAnsi / embedded subsetHelveticaNeue TrueType (CID) / Identity-H / embedded subsetHelveticaNeue-Bold TrueType / WinAnsi / embedded subsetHelveticaNeue-Bold TrueType (CID) / Identity-H / embedded subsetHelveticaNeue-Light TrueType / WinAnsi / embedded subsetHelveticaNeue-Thin TrueType / WinAnsi / embedded subsetSchulbuchNord-Normal Type1 / WinAnsi / embedded subsetTimesTen-BoldItalic Type1 / WinAnsi / embedded subsetTimesTen-Italic Type1 / WinAnsi / embedded subset


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