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FRESHMEN YEAR PROGRAM MEDICAL

SCHOOL UNIVERSITAS PADJADJARAN

Transport of Oxygen and Carbon

Dioxide

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Oxygen Content of Systemic Arterial

Blood at Sea Level

1 L arterial blood contain

3 ml O2physically dissolved (1.5%)

197 ml O2bound to Hemoglobin

(98.5%)Total 200 ml O2

Cardiac output = 5 L/min

O2carried to tissue/min = 5L/min x 200 ml O2/L

= 1000 ml O2/min

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Hemoglobin and Oxygen Partial

Pressure

O2Hb

dissociation

curve at normal

body

temperature

As pO2increase,

more O2

combines withhemoglobin

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Hemoglobin saturation and pH

The effect pH on

affinity ofhemoglobin foroxygen

As pH decrease,

the affinity ofhemoglobin forO2is less, soless O2combines

with hemoglobinand more isavailable totissue

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Hemoglobin Saturation and PCO2

As pCO2

increase , the

affinity of

hemoglobinfor O2

decrease

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Hemoglobin saturation and

Temperature

As temperature

increase, the

affinity of

hemoglobin for O2

decreases

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Fetal Hemoglobin

Oxygen

hemoglobin

dissociation

curve

comparingfetal and

maternal

hemoglobin

Fetal Hb has ahigher affinity

for O2than

does adult Hb

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TRANSPOR OF HYDROGEN IONS

BETWEEN TISSUES AND LUNGS

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Hypoxia

Hypoxic hypoxia Low pO2 in arterial blood: high altitude, airways

obstruction, fluid in lung

Anemic hypoxia Low Hb: hemorrhage, anemia, CO poisoning

Stagnant (ischemic) hypoxia Low tissue blood flow

Histotoxic hypoxia Tissue unable uses O2 properly

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Carbon Dioxide Transport

1. Dissolved CO2: 7% dissolved in plasma

2. Carbaminohemoglobin

Hb + CO2 HbCO2

3. Bicarbonate ions

CO2+ H2O H2CO

3 H+

+ HCO3-

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Carbon Dioxide Transport (cont)

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Carbon Dioxide Transport (cont)

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Summary of Gas Exchange and Transport in Lung and Tissue

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Thanks for Your Attention