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Pathology(2007/2008)- For Pharmacy Pathophysiology(2007/2008) -For Nursing
.M.B., Ch.B., Ph.D
- -
October 2007Amman-Jordan
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Assessment Examinations:
Tutorials During Lectures 10 marksFirst Examination 20 marksSecond Examination 20 marks
Final Examination 50 marks
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:Recommended Books
Muir`s Textbook of Pathology .1-2008
(Pathophysiology (By: C.M.Porth 2004 .2 ISBN: 0-7817-4645-0
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Course Outline
Neoplasm6Inflammations & Infections5
Disturbances of Hemostasis ))Hemorrhage, Thrombosis & Embolisms4Disturbances of Acid-Base Balance ))Acidosis & Alkalosis3
Disturbances of Homeostasis ) ) Dehydration & Edema2Introduction, Etiology ,Cell Damage1
General Pathology
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Pathology/Pathophysiology Study of abnormal variations in:
Development, Function & Structure of Tissues
Disease is:Abnormal Tissue ChangesResulting in:
Clinical Signs & Symptoms
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Pathogenic .M.O
Cellulitis ( Diffuse Subcutaneous Streptococcal Infection )
Abscess )Localized Staphylococcal Infection )
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Harmful Effects of Smoke
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Tutorials (Explain following photographs)
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Hypertrophy is Enlargement of Tissue by increase in size of cells
Normal Heart Cardiac Hypertrophy
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Normal Distribution of Body Water Physiology of Body Fluids:Normal Adult Weight = 70 Kg. Normal Adult Body Water = 60 %
Intracellular water 43 % 30 litersExtracellular water
Intercellular water ( interstitial )
13 % 9 litersIntravascular water = 4 % 3 liters________ ___________
60 % 42 liters
Microcirculation
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Control of Normal Body Water Distribution1. Capillary Hydrostatic Pressure of ( 32-12 mm Hg )
( Plasma Osmotic Pressure of ( 22 mm Hg .2
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: Disturbances of Hemostasis
Hemorrhage (Bleeding Disorder)
Thrombosis (Gradual Vascular Occlusion)
3. Embolism (Sudden Arterial Occlusion)
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Pathological Thrombosis
Useful Thrombus leads to Arrest Bleeding Harmful Thrombus leads to vascular occlusion
Gradual Formation of Semi-Solid Mass from Blood Constituents( Platelets + Fibrin )
Inside Cardio Vascular System
DURING LIFE
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Causes of Thrombosis1. Endothelial damage ( Atheroma )
3. Slow blood flow..
6. Varicose veins
10.Tobacco smoking
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:Fate of Thrombosis Resolution by Fibrinolysis
Occlusion of blood vessels ( Gradual Process )
Embolism ( Sudden Process )
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:Effects of Embolisms
Sudden Arterialocclusion Sudden Tissue Ischemia Followed by Tissue Infarction ___________________________________________________
Blocked by embolus
Tissue ischemia
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LocalizedArterial DisturbancesHyperemia : Increased arterial blood flow to localized Microcirculation
Abscess Cellulitis