8/12/2019 Genetica1 Studii Gemelare 2012

1/17

Studii gemelare i de adopien genetica comportamental

8/12/2019 Genetica1 Studii Gemelare 2012

2/17

Domenii relevante

Genetica comportamentala

Genetica psihiatrica (engl., psychiatricgenetics)

Farmacogenetica Neuroimagistica genetica (engl., genetic

neuroimaging)

Psihologie genomica?!

Epigenetica

Therapygenetics

8/12/2019 Genetica1 Studii Gemelare 2012

3/17

Generaliti

1960, J. L. Fuller & W. R. Thompson,

prima carte numitBehavior Genetics

1970, nfiinarea Behavior Genetics

Association i a jurnalului BehaviorGenetics

8/12/2019 Genetica1 Studii Gemelare 2012

4/17

Puncte de vedereI think I may say, that all the Men we meet with, nine parts of ten are

what they are, good or evil, useful or not, by their Education (John

Locke, An Essay Concerning Human Understanding, 1690)

There is no escape from the conclusion that nature prevailsenormously over nurture when the differences of nurture do notexceed what is commonly to be found among persons of the same

rank of society and in the same country. (Francis Galton, Inquiriesinto Human Faculty, 1883)

Give me a dozen healthy infants, well-formed, and my own specifiedworld to bring them up in and Ill guarantee to take any one at

random and train him to become any type of specialist I might select doctor, lawyer, artist, merchant-chief, and yes, even beggar-manand thief, regardless of his talents, penchants, tendencies, abilities,vocations, and race of his ancestors. (John B. Watson,Behaviorism, 1925)

8/12/2019 Genetica1 Studii Gemelare 2012

5/17

Metode

Agregare familiala

Studii gemelare

Linkaj

Studii de asociere genetica

8/12/2019 Genetica1 Studii Gemelare 2012

6/17

Studii de adopie

8/12/2019 Genetica1 Studii Gemelare 2012

7/17

Studii gemelare rMZ = h

2 + c2

rDZ = (1/2) h2 + c2

h2 = 2 (rMZ rDZ)

8/12/2019 Genetica1 Studii Gemelare 2012

8/17

Studii gemelare rMZ = h

2 + c2

rDZ = (1/2) h2 + c2

h2 = 2 (rMZ rDZ)

8/12/2019 Genetica1 Studii Gemelare 2012

9/17

8/12/2019 Genetica1 Studii Gemelare 2012

10/17

Exemple (studii gemelare)

Plomin, Owen, & McGuffin, Science, 1994

8/12/2019 Genetica1 Studii Gemelare 2012

11/17

Exemple (studii gemelare)

Plomin, Owen, & McGuffin, Science, 1994

8/12/2019 Genetica1 Studii Gemelare 2012

12/17

Exemple (studii gemelare)

8/12/2019 Genetica1 Studii Gemelare 2012

13/17

Minnesota Study of Twins Reared Apart

Tellegen et al., JPSP, 1988

8/12/2019 Genetica1 Studii Gemelare 2012

14/17

Minnesota Study of Twins Reared Apart

Tellegen et al., JPSP, 1988

8/12/2019 Genetica1 Studii Gemelare 2012

15/17

Minnesota Study of Twins Reared Apart

Bouchard et al., Science, 1990

8/12/2019 Genetica1 Studii Gemelare 2012

16/17

Minnesota Study of Twins Reared Apart

Bouchard et al., Science, 1990

8/12/2019 Genetica1 Studii Gemelare 2012

17/17

Psychologists have beensurprised by the evidence thatbeing reared by the sameparents in the same physicalenvironment does not, onaverage, make siblings more

alike as adults than they wouldhave been if reared separatelyin adoptive homes. It isobvious that parents canproduce shared effects if theygrossly deprive or mistreat all

their children. It seemsreasonable that charismatic,dedicated parents, determinedto make all their children sharecertain personal qualities,

interests, or values, maysometimes succeed.

Bouchard et al., 1990

Humans are exploring organismswhose innate abilities andpredispositions help themselect what is relevant and

adaptive from the range ofopportunities and stimulipresented in the environment.The effects of mobility andlearning, therefore, augmentrather than eradicate the

effects of the genotype onbehavior.

Martin et al., 1986