Genetics evolution

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10,000 BC 2016

Genetic evolution

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MU announces PRRS resistant pig

Selective breeding Directed recombination? Domestication

1900 AD 2000 2010 2015 10,000 BC

Relationship Based Genomics

Efficiency & sustainability prolificacy, feed efficiency, health & robustness

Meat quality taste, leanness, yield

Gene editing ‘invented’

Darwin develops evolution theory

First transgenic Crop introduced

Shull describes heterosis

Cost to sequence drops factor 1000 in 3 years

Mendel ‘invents’ genetic science

Watson & Crick describe DNA molecule

Human Genome Project completed

Selective breeding

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Genetic Improvement (ΔG)

Parents Children

Selective breeding works

Prolificacy

1960s 2010s

14 pigs Per year

28 pigs Per year

+100%

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900 lbs of feed each pig

550 lbs of feed each pig

-40%

Selective breeding works

Feed conversion

1960s 2010s

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Manure per lbs of lean meat reduced by more than 60%

350 lbs of feed x 1 bln hogs = …

Meat quality

75 lbs of lean each pig

120 lbs of lean each pig

+60%

Selective breeding works

1960s 2010s

Selective breeding works

Prolificacy

Feed conversion

Meat quality

1960s 2010s

14 pigs Per year

28 pigs Per year

900 lbs of feed each pig

550 lbs of feed each pig

75 lbs of lean each pig

120 lbs of lean each pig

+100%

-40%

+60%

Manure reduced per lb of lean meat by more than 60%

Accelerating genetic gain: what’s next?

Gene Editing

The next frontier…

The blight of PRRS

PRRSv has challenged the swine industry for ~30 years There is no cure, existing treatment has limited effect PRRSv cost global pork over $4bln each year

Waste of animal well-being, feed, and human emotion

Delivering unique value

PRRS resistance A high level overview

•  Pigs were created with minor nucleotide edits within their existing DNA

•  No new or foreign DNA was inserted into the pigs

Genetics revolution

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10,000 BC 2016 2020

Evolution Revolution?

Realizing the future

•  We don’t have the perfect pig but that simple possibility excites and drives us

•  Genetic improvement is accelerating at a faster pace than ever before

•  Breakthrough technologies will further accelerate this pace of change

•  Continued investment in service and support creates the greatest focus on opportunities and probability of success

PIC is dedicated to the responsible exploration of innovations that benefit the well-being of animals, farmers, and society

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