GENReports: Market & Tech Analysis, Produced by Oosta and Razvi © 2015 GENengnews.com
> Enal Razvi, Ph.D. > Gary Oosta, Ph.D. Managing Director Select Biosciences, Inc. [email protected] Twitter: @enalrazvi
Biotechnology Analyst, Select Biosciences, Inc.
GENReports: Market & Tech Analysis
GENReports: Market & Tech Analysis, Produced by Oosta and Razvi © 2015 GENengnews.com
Deep Analysis of Exosomes Marketplace from the BoBom-‐Up
Scope of this Report: § There is the unmet need to characterize the dynamics of the exosomes and
broader extracellular vesicles marketplace as it is rapidly evolving and highly granular with lots of market segments
§ Select Biosciences has been tracking this field for the past several years and our conEnuing industry coverage allows us to pinpoint trends in this space
§ In this report, we present a snapshot of this complex space and map its evoluEon—this is part I of a three-‐part report—in this part I we present the “macro landscape” of exosomes
We Present Here:
§ An overall landscape of Exosome publicaEon acEvity § Trends in specific segments within the exosome landscape § An idenEficaEon of segments (disease classes, tools and methods in exosome
research) that are responsible for growth § Data and Analysis are up-‐to-‐date as of June 2015
GENReports: Market & Tech Analysis, Produced by Oosta and Razvi © 2015 GENengnews.com
Based on PublicaUon AcUvity, Interest in Exosomes is Growing at a Nearly ExponenUal Pace
We will focus the analysis presented here on the years 2000-‐2015, where the publicaEon rates are highest.
GENReports: Market & Tech Analysis, Produced by Oosta and Razvi © 2015 GENengnews.com
The Exosome Space is Composed of 35,730 PublicaUons
The Exosomes Word Cloud: A Picture is Worth a Thousand Words
GENReports: Market & Tech Analysis, Produced by Oosta and Razvi © 2015 GENengnews.com
Trends in Exosome Terminology suggests that the Overlapping Terminology Star%ng to Clarify
Exosome
Extracellular Vesicle
One Metric for the EvoluEon/MaturaEon of the Exosomes Field is the Clarity of Nomenclature
GENReports: Market & Tech Analysis, Produced by Oosta and Razvi © 2015 GENengnews.com
Trends in DetecUon Methods for Exosome Research in the Academic Literature.
§ Flow Cytometry: Growing in Penetrance in the Exosomes Space § Analysis of Individual Exosomes and Exosome Subsets Defined by Surface Phenotype
GENReports: Market & Tech Analysis, Produced by Oosta and Razvi © 2015 GENengnews.com
Trends in Tool Usage for Exosome Research in the Academic Literature
Expanding Segments § Flow Cytometry § Western BloYng § Imaging § Mass Spectrometry § UltracentrifugaEon
GENReports: Market & Tech Analysis, Produced by Oosta and Razvi © 2015 GENengnews.com
PCR remains a Key Tool: qPCR is an Emerging trend in Exosome Research
The InterrogaUon of RNA Cargo in Exosomes
GENReports: Market & Tech Analysis, Produced by Oosta and Razvi © 2015 GENengnews.com
Micro-‐ & Nano-‐ in Exosomes
• The Impact of Microfluidics on Exosome Research is SEll Small
• We however believe that the
InterrogaEon of CirculaUng Biomarkers via Microfluidics, Lab-‐on-‐a-‐Chip Approaches will ConsEtute an Emerging Theme Going Forward
GENReports: Market & Tech Analysis, Produced by Oosta and Razvi © 2015 GENengnews.com
Exosome Research Market SegmentaUon by Biofluid Class
Emerging Biofluid Classes
Various Biofluid Classes Enable the Development of Biofluid Biopsies (Liquid Biopsies)
Top Classes § Blood § Plasma § Serum
GENReports: Market & Tech Analysis, Produced by Oosta and Razvi © 2015 GENengnews.com
Next-‐Gen Sequencing & Whole Genome Amp. Surprisingly Limited Impact on Exosome Research to Date
§ NGS: Only Beginning to Impact Exosome Research § Whole Genome Analysis: Not Applicable since Exosomes Don’t Carry the Whole Genome
GENReports: Market & Tech Analysis, Produced by Oosta and Razvi © 2015 GENengnews.com
Classes of Cargo Analyzed in Exosomes
§ Nucleic Acids and Proteins are the Top Currently § EpigeneEc Analyses and Lipid Analyses are Nascent
GENReports: Market & Tech Analysis, Produced by Oosta and Razvi © 2015 GENengnews.com
Conclusions and Outlook for the Field
§ The analysis presented here is the most up-‐to-‐date market analysis of the exosomes space—this is the first of 3 reports we will be publishing on this topic
§ Given the fact that the exosomes field is highly-‐fragmented across several thousand researchers over several conEnents, the only way to analyze the field en bloc is to study the enEre current academic literature in the field and then draw conclusions based on trends operaEve therein
§ Our system has enabled us to analyze all of the 35,730 publicaEons that together comprise the extracellular vesicles (EV) field – therefore, we can view major trends as well as minuEae as they are developing
§ We document the expansion of specific methodologies such as flow cytometry that are expanding in penetrance in the exosomes field
§ We also analyze here the various analyte classes that are being studied in the exosomes space – some of these analytes today represent circulaEng biomarkers of the future
GENReports: Market & Tech Analysis, Produced by Oosta and Razvi © 2015 GENengnews.com
Select Biosciences bring all the key opinion leaders (KOLs) in the Liquid Biopsies Space Together
Focus on Exosomes, CirculaUng DNA, CirculaUng RNA, CirculaUng Tumor Cells (CTCs)
For More InformaEon About the Conference,
Please Scan the QR Code to the Right with your Mobile Device
(iPhone, iPad, Android)
For More InformaUon, Please Contact: [email protected]
