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LET’S DISCUSS HOW TO
Differentiate delirium, depression &
dementia.
Describe the etiology and signs and
symptoms of delirium, depression, and
dementia.
Identify risk factors for delirium,
depression, and dementia.
LET’S DISCUSS HOW TO
Identify types of medications that may
cause depression.
Communicate and care for people
experiencing delirium.
Explain non-pharmacologic interventions
for treating dementia.
DELIRIUM
Cholinergic/dopaminergic excess
Cascade of events
Complicates hospitalizations
Is a medical emergency
Durso, S. C. & et al. (2010).
Sometimes preventable by minimizing medication use and adequate hydration
Glutamate
Activation
GABA
Activation
Reduced
GABA
Activity
Cholinergic Inhibition
Dopamine
Activation
Cytokine Excess
Serotonin
Activation
Serotonin
Deficiency
Cortisol
ExcessHepatic
Failure
&
Alcohol
Withdrawal
Benzo’s
&
Hepatic
Failure
Benzo’s &
ETOH
Withdrawal
Medications
Surgical &
Medical Illness
Cholinergic Activation
Medications
Alcohol
Withdrawal
Medications
Substance
Withdrawal
Glucocorticoids
Stroke
Surgery
Surgical &
Medical Illness
Medications
Stroke
COMMUNICATION IN DELIRIUM
Know the person’s
patterns
Look at nonverbal
signs
Speak slowly
Explain all actions
Be calm
Face the person
keep eye contact
Get to the level of
the person, don’t
stand over them
Touhy, T. & Jett, K. (2012).
COMMUNICATION IN DELIRIUM
Smile
Use simple familiar
words
Allow adequate time
for response
Repeat if needed
BE Consistent
Tell the person what
you want them to do
One-step directions
Reassure safety
Do not assume they
cannot understand
Touhy, T. & Jett, K. (2012).
REVERSIBLE FACTORS
Drugs
Electrolyte imbalance
Lack of drugs
Infection
Reduced sensory input
Intracranial
Urinary retention/fecal impaction
Myocardial/Pulmonary
DEPRESSION
Not a normal part of aging
Most common mental health problem of late life
Among the most treatable
Often co-occurs illness “unwanted cotraveler”
Up to 1 in 4 primary care clients suffer from
depression
Touhy, T. & Jett, K. (2012).
MEDICATIONS MAY RESULT IN DEPRESSIVE SYMPTOMS
Antihypertensives
Angiotensin-
Converting Enzyme
Inhibitors
Antidysrhythmics
Anticholesteremics
Antibiotics
Analgesics
Corticosteroids
Touhy, T. & Jett, K. (2012).
DEPRESSION
Two simple questions effectively
screen:
Over the past 2 weeks, have you felt
down, depressed or hopeless?
Have you experienced a loss of
interest or pleasure in most things?
Durso, S. C. & et al. (2010).
DEPRESSIONSupportive treatment
Counseling, relief of loneliness
Treat physical symptoms and pain
Address anxiety, financial, dependency
Consider stopping contributory drugs
Psychotherapy effective as antidepressants
Cognitive-behavioral therapy
comprehension
DEMENTIA
The term dementia describes a syndrome
Chronic and progressive brain disease
Affects higher cortical functions
memory
language
judgment
learning
capacity
thinking orientation
calculation
Bereczki, D. & Szatmári, S. (2009).
IMPACT
35.6 million with dementia
Nearly doubles every 20 years
Alzheimer’s in the USA will
ALMOST TRIPLE BY 2050
World Alzheimer Report 2011.
28 million of the world’s 35.6 million people with
dementia have yet to receive a
diagnosis…
World Alzheimer Report 2011.
Annual dementia
care costs
$32,865
per person
With a quality
dementia diagnosis
annual dementia cost
decreases to $5,000
per person
Improved health & quality of life
even more cost-effective
Impact of a Quality Dementia Diagnosis
World Alzheimer Report 2011.
Earlier diagnosis allows people with dementia to…
plan ahead while
they still have the
capacity, receive
timely practical
information, advice
and support
get access to available
drug and non-drug
therapies
participate in
research for the
benefit of future
generations
World Alzheimer Report 2011.
7.7 million new cases yearly.New case of dementia every?
A. 18 minutes
B. 23 hours
C. 4 seconds
D. 23 minutes
E. 30 seconds
C. 4 seconds
0 1 2 3 4 5 6
DEMENTIA
WAL-MART
EXXON MOBIL
100 BILLION US DOLLARS
Dementia Costs More Than 1% Gross Domestic Product
Borson, S. & et al. (2013).
If dementia were a company, it would be the world’s largest by annual revenue.
RISKAge
Family history and genetics
Psychiatric disorders
Cardiovascular disease – related factors
Head trauma
Alcohol, drugs & toxins
Vasculitis, Endocrine & Infectious disorders
Neoplastic & Respiratory disorders
Brain lesions, normal pressure hydrocephalus
Fillit, H. M. & et al. (2010) & Patterson, C. & et al. (2007).
MILD COGNITIVE IMPAIRMENT
NOT the result of normal aging
Forgetfulness is hallmark symptom
Sometimes called a transitional phase
Conversion rate 2 - 15% per year
Up to 80% conversion at 6 years
Fillit, H. M. & et al. (2010).
MAJOR DEMENTIA TYPES
AD Alzheimer’s disease
VaD Vascular dementia
FTD Frontotemporal dementia
PDD Parkinson’s disease dementia
DLB Dementia with Lewy bodies
Others: SD Semantic dementia, Progressive
nonfluent aphasia, etc.
NEUROPSYCHOLOGICAL DOMAINS
Premorbid ability: review of
educational, occupation
Verbal memory: verbal and
memory learning tests
Visual memory: visual
reproduction, figure drawing
Simple attention: digit span
Language: animal naming, oral
word association test
Executive function: card
sort test, similarities
Visuospatial: digit symbol
test, clock drawing
Motor: finger tapping
Cognitive screening:
MMSE, SLUMS, MoCA, etc.
Fillit, H. M. & et al. (2010).
OTHER DOMAINS
FunctionKatz Index of Activities of Daily Living ADL
Lawton Instrumental Activities of Daily Living Scale IADL
Get-up and go
Caregiver Input
DepressionHamilton Depression Rating Scale HDRS
Geriatric Depression Scale GDS
Fillit, H. M. & et al. (2010).
DIAGNOSTIC
LABORATORYCBC, CMP, Thyroid, B12, Folate, CRP, RPR, Lipids, HIV, SED rate, etc.
May need to rule out delirium urine sample, blood cultures, chest x-ray, CSF
NeuroimagingMRI or CT - Choice depends on availability, cost, patient acceptability, contraindicationMRI is preferred. SPECT & PET scanning, Pittsburgh Compound-B ligand for PET
Fillit, H. M. & et al. (2010).
Reports of progressive
change in cognition or ADL
Clinical assessment
Is cognitive impairment
confirmed on formal testing?
Is ADL impaired
Is onset relatively sudden
with disturbed attention?
Investigations, including
neuroimaging
Is a non-vascular etiology for
dementia identified?
Is a vascular etiology for
dementia identified?
Is parkinsonism, visual hallucinations
or fluctuating cognition present?
Is presentation with isolated
language and/or executive deficits?
Is episodic memory deficit prominent?
Consider depression,
anxiety, normal agingNO
NOMild Cognitive
Impairment
YES Delirium
Is cognitive impairment
persistent despite
appropriate treatment YES
YESToxic, NPH, tumor, Huntington, head
injury, MS, HIV, Neurosyphilis, CJD,
metabolic – thyroid, B12 deficiency
YESVascular dementia,
SDH, vasculitis
YESDementia with Lewy bodies,
Parkinson’s disease dementia
YES Frontotemporal dementia
YES Alzheimer’s disease
DIAGNOSTIC PROCESS F
illi
t, H
. M
. &
et
al.
(2
010
).
ALZHEIMER’S DISEASEImpairment in memory
Functional impairment social
or vocational
And impairment in one other
cognitive areaAgnosia - impaired ability recognize objects
Aphasia - language disturbances in expressing,
understanding
Apraxia - inability to carry out motor activities
Attention
Executive function
Visuospatial ability
Other criteria:
Progression is
insidious and
other diseases that
could cause
cognitive decline
have been ruled
out, diagnosis is
primarily based on
clinical judgment.
Fillit, H. M. & et al. (2010).
AD - Damage to plaque and neurofibrillary tangles, synapse
loss, atrophy starts medial temporal lobe
SIGNS AND SYMPTOMSUnderstanding Language
Processing Auditory Information
Organizing InformationMemory Learning
JILL, 86 YO CAUCASIAN FEMALE, COMPLETED SOME COLLEGE
CAM: negative
ADLs: Independent in eating & transfer
IADLs: Dependent in ALL
GDS: 4/15, negative
Labs: not remarkable
Brain Imaging: Diffuse atrophy
PMH: HTN, DM II, CAD
Physical Exam: Confabulates
Increasingly more forgetful for the past 6 months…
CAM - negative
No Feature 1: Acute Onset or Fluctuating Course
No Feature 2: Inattention
No Feature 3: Disorganized thinking
No Feature 4: Altered Level of consciousness
The diagnosis of delirium by CAM requires the presence of features 1 and 2 and either 3 or 4.
Inouye, S. & et al. (1990).
Feature Delirium Dementia Depression
Onset Sudden Insidious Recent
Course over 24 Hours
Fluctuates, often worse at night
Fairly stable Fairly stable, may be worse in
the morning
Consciousness Reduced Clear Clear
Alertness Variable Normal Normal
Psychomotor Activity
Variable, mixed Normal Variable, mixed
Attention Concentration
Disordered Normal LittleImpairment
Orientation Impaired, fluctuates
Impaired, tries to answer,
confabulates
Usually normal,“I don’t know” may try not to
answer
Speech Often incoherent, slow
or raid
Word finding, perseveration
May be slow
Touhy, T. & Jett, K. (2012).
VASCULAR DEMENTIA
Second most prevalent dementia 1/3
Also know as multi-infarct dementia
The brain has multiple vascular lesions in the cortex and subcortical areas, sometimes called “small strokes”
Memory loss most common complaint
The cognitive changes that occur are directly related to the location of the lesions
Working memory more likely to be impaired more than delayed recall
Fillit, H. M. & et al. (2010).
VASCULAR DEMENTIA
Cued recall
recognition
previously
learned
material
generally
intact
Executive
dysfunction
more
commonly
reported than
in AD
Depression
common
Fillit, H. M. & et al. (2010).
JOHN, 70 YO CAUCASIAN MALE, RETIRED PHARMACIST
CAM: negative
ADLs: Independent in ALL
IADLs: Dependent in ALL
GDS: 3/15, negative
Labs: ESRD
PMH: Insulin dependent diabetic
Physical Exam: gait imbalance, due
worsening vision/peripheral neuropathy
Reports he trusts his wife to make all his decisions as he no longer can, “I do whatever
she wants…”
JOHN’S MRI
MRI Brain:
Small punctate acute ischemic lesion
in the right hippocampus, diffuse
extensive chronic white matter
microvascular ischemic changes and
volume loss advanced for age.
Functional Assessment Staging (FAST)
Stage 1 Normal adult.
No functional decline.
Stage 2 Normal older adult.
Personal awareness of some functional
decline.
Stage 3 Early AD. Noticeable deficits
in demanding job situations.
Stage 4 Mild AD. Requires assistance
in complicated tasks such as handling
finances, planning parties, etc.
Stage 5 Moderate AD.
Requires assistance in choosing proper attire.
Stage 6 Moderately Severe AD.
Requires assistance dressing, bathing, and toileting. Experiences urinary and fecal incontinence.
Stage 7 Severe AD.
Speech ability declines to about a half-dozen intelligible words. Progressive loss of the ability to walk, sit-up, smile, and hold head up.
maintaining reestablishing independence
Improving andstabilizing cognitive
ability and mood
TREATMENT GOALS
effective future planning
symptom management
orientating redirecting
pharmacologic therapies
daily caresafety as needed
Fillit, H. M. & et al. (2010) & Bereczki, D. & Szatmári, S. (2009).
caregiver interventions
nonpharmacologic
promoting autonomy
NON-PHARMACOLOGIC INTERVENTIONS
DEMENTIAPerson-Centered Care
Structure the environment and relationships to
maintain stability – Stable & Predictable
Establish a caring relationship
Provide unconditional positive regard
Find causes of behavior, identify triggers
Provide as much control as possible
Touhy, T. & Jett, K. (2012).
NON-PHARMACOLOGIC INTERVENTIONS
DEMENTIAReduce environmental distractions
Approach from the front, make eye contact,
address person by name, speak in calm voice
To reduce sense of threat, talk first, then touch
Avoid verbal testing or questioning beyond the
person’s ability
Do not argue or insist they accept your reality
PHARMACOLOGIC INTERVENTIONS
Considerable
variation in clinical
practice regarding
pharmacological
treatment of
dementias
Bereczki, D. & Szatmári, S. (2009).
DEMENTIA KEY FINDINGS
Most people wish to be told of their diagnosis
Improving the likelihood of earlier diagnosis:
medical practice-based educational programs,
introduction of accessible dementia care services,
promoting effective interaction in the health system
Early therapeutic interventions:
improving cognitive function, treating depression,
improving caregiver mood, delaying
institutionalization
World Alzheimer Report 2011
What’s Your Story?"ElderlyWomanInGlasses". Licensed under CC BY-SA 3.0 via Wikimedia Commons -http://commons.wikimedia.org/wiki/File:ElderlyWomanInGlasses.jpg#mediaviewer
/File:ElderlyWomanInGlasses.jpg
Bereczki D, Szatmári S. Treatment of dementia and cognitive impairment:
What can we learn from the Cochrane library. J Neurol Sci [Internet]. 2009
8/15;283(1–2):207-10.
Borson S, Frank L, Bayley PJ, Boustani M, Dean M, Lin P, McCarten JR,
Morris JC, Salmon DP, Schmitt FA, Stefanacci RG, Mendiondo MS, Peschin S,
Hall EJ, Fillit H, Ashford JW. Improving dementia care: The role of screening
and detection of cognitive impairment. Alzheimer's & Dementia [Internet].
2013 3;9(2):151-9.
de Vugt ME, Verhey FRJ. The impact of early dementia diagnosis and
intervention on informal caregivers. Prog Neurobiol [Internet]. 2013 In Press.
Durso, S. C., Bowker, L. K., Price, J. D., & Smith, S. C. (Eds.). (2010). Oxford
American handbook of geriatric medicine (First ed.). New York, New York:
Oxford University Press Inc.
REFERENCES
Fillit HM, Rockwood K, Woodhouse K. The nervous system In:
Brocklehurst's textbook of geriatric medicine and gerontology. 7th ed.
Philadelphia: Elsevier; 2010; p. 385-432.
Inouye, S., van Dyck, C., Alessi, C., Balkin, S., Siegal, A. & Horwitz, R. (1990).
Clarifying confusion: The confusion assessment method. Annals of
Internal Medicine, 113(12), 941-948.
Patterson C, Feightner J, Garcia A, MacKnight C. General risk factors for
dementia: A systematic evidence review. Alzheimer's & Dementia [Internet].
2007 10;3(4):341-7.
Touhy, T. & Jett, K. (2012). Ebersole & Hess’ Toward healthy aging: Human
needs and nursing response, 8th edition. St. Louis: Elsevier Mosby.
Special Thank You: Department of Veterans Affairs, Saint Louis University, SLUMS Examination. World Alzheimer Report 2009 & 2011.
REFERENCES