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GI Summer Review -Answers- Bosch (2013)

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  • 8/11/2019 GI Summer Review -Answers- Bosch (2013)

    1/16

  • 8/11/2019 GI Summer Review -Answers- Bosch (2013)

    2/16

    2013

    Gl

    Summer

    Review;

    Barbara

    D

    Bosch.

    M D page 2

    A

    34 year-old

    man comes

    to

    the emergency

    department

    complaining

    of the

    sudden onset of

    vomiting

    an d epigastric

    abdominal

    pain

    radiating

    to

    the

    back.

    On

    physical

    examination,

    the patient is

    afebrile

    and has abdominal

    tenderness;

    decreased bowel sounds are

    noted,

    as is

    diffuse bruising that

    he

    describes as

    having appeared suddenly. He

    also reports continuous

    epistaxis.

    Laboratory tests

    show

    a slightly

    elevated

    WBC

    count,

    thrombocytopenia,

    increased

    amylase an d

    lipase activity,

    increased

    prothrombin time

    (PT)

    an d

    partial

    thromboplastin

    time (PTT), and the presence

    of fibrin split products.

    An

    abdominal

    ultrasound

    performed

    at

    the

    bedside

    shows a

    dilated common bile

    duc t. Wh ich

    of the

    following

    is the

    most likely etiology of

    this

    patient's

    abnormal

    coagulation

    profile?

    A. abdominal aortic

    aneurysm

    meag+ \

    ,

    20?

    acute pancreatitis

    Vv

    *

    y*

    *

    C.

    appendicitis

    FK?*>

    .

    V

    ?

    \

    '

    ,*

    D. gastric

    ulcer

    \

    2

    '*>

    .*,

    W

    E.

    gram-negative sepsis

    boA

    Jf?

    In the

    H&E-stained

    photomicrograph, the

    arrow points

    to which o f the

    following specific

    structures?

    central

    (hepatic)

    vein

    hepatic artery

    5?

    portal

    vein

    D.

    sinusoid

    E.

    space of Disse

    On

    the

    da y

    of the

    BaL*aaBrcafcQn-in

    pathology,

    a 26 year-old medical student notices that he r

    sclerae have a

    sfightyellowish

    color.

    She ha s never

    ha d

    a major illness. On physical exam,

    there

    are

    no

    significant

    findings other than the

    mild scleral icterus.

    Laboratory studies

    revea l a total bilirubin

    of

    4.9 mg/dL

    (normal

    0.1-1.0

    mg/dL)

    with a

    direct

    bilirubin of 0.8

    mg/dL (normal

    0.0-0.3

    mg/dL). The

    scleral icterus resolves within

    2

    days. Which

    of

    the following conditions

    is

    most

    likely

    to produce

    these

    findings?

    IV

    /

    A.

    acute

    hepatitis

    A

    virus

    infection

    y

    \

    B.

    Dubin-Johnson

    syndrome

    hST

    & n

    tQ)

    Gilbert

    syndrome

    T*

    D.

    ingestion of acetaminophen

    -

    o>

    A

    60

    year-old

    woman presents to

    the

    physician

    with

    painlesy?eddish-brown

    blood

    in

    heTstooT)

    Initial

    laboratory

    tests show

    the

    following

    results:

    hematocrit:

    33%

    (normal

    36-46%)

    hemoglobin:

    11

    g/d

    L

    (normal

    12-16

    g/dL)

    mean corpuscular volume: 73

    pm 3

    (normal

    80-100

    pm3)

    white blood

    cell count:

    8,000/mm3

    (normal

    4,500-1

    1

    ,000/mm3)

    platelet

    count:

    200,

    000/mm3

    (normal

    150,

    000-400,

    000/mm3)

    Which of

    the following

    is

    the

    most

    important next

    step

    in

    the

    management

    of

    this

    patient?

    A.

    abdominal plain

    films

    colonoscopy

    C.

    CT scan of

    the abdomen

    D.

    esophagoduodenoscopy

    E.

    pelvic

    ultrasound

    A patient

    presents to

    the

    emergency

    room

    withTpper

    Gl

    bleeding

    Administration

    of

    an agonist/

    analog

    of

    which of the

    following agents

    would inhibit

    gastric,

    ar.id

    spr.rpfinn?

    *

    /K.

    acetylcholine

    gastrin

    -6T

    histamine

    pepsin

    somatostatin

    i

  • 8/11/2019 GI Summer Review -Answers- Bosch (2013)

    3/16

    2013

    Gl

    Summer

    Review;

    Barbara

    D.

    Bosch, M.D.

    page

    3

    A2year-olchild

    presents

    with_a

    history

    ofeonataT

    )7nchT

    UJ1CV

    _

    _

    _

    _ _

    as

    well

    as

    aQhronic

    cougand

    SluincgFironirdiafrhea

    frjthliqhlcolored

    Joul-smelling

    stools.

    A

    deTiciency

    of

    which

    of

    the

    following

    vitamins could

    develop?

    A. ascorbic

    acid

    B. folate

    C.

    niacin

    retinolCvi*

    Ay

    E.

    riboflavin

    F.

    thiamine

    d\

    ~

    C-Vk-oAWLXj*

    You recommend a

    colonoscopy to

    a

    50

    year-old

    patient.

    He agrees, bu t

    wants

    you

    to

    describe

    the

    procedure

    an d

    potential

    risks and

    complications.

    You

    explain

    that the goal of

    the

    procedure

    is to

    look

    at

    the

    entire length

    of the

    large

    intestine with

    a

    flexible

    fiberoptic colonoscope

    and

    to biopsy

    any

    observable lesions.

    You tell him that

    there

    is

    a small risk of perforating the

    bowel,

    especially

    when

    the

    colon takes a sudden turn or

    twists

    on itself

    at

    regions

    where

    it

    is

    intraperitoneal

    rather

    than attached

    to the

    posterior

    abdominal

    wall

    (retroperitoneal). With your

    knowledge

    of

    anatomy,

    which

    of

    the

    following regions

    of the large

    intestine pose

    the

    greatest

    risk for

    perforation

    to

    the

    gastroenterologist?

    A . a sc en din g

    colon,

    transverse colon and descending colon

    B.

    descending

    colon,

    sigmoid

    colon an d

    rectum

    yC>

    hepatic

    flexure,

    splenic

    flexure

    and

    sigmoid

    colon

    D.

    hepatic

    flexure,

    transverse colon and

    splenic

    flexure

    E. splenic

    flexure,

    descending

    colon

    an d sigmoid

    colon

    A

    hepatitis panel

    is

    ordered

    for a

    27

    year-old

    woman as

    part

    of a routine workup for

    abdominal

    pain.

    Results

    of serologic testing

    are negative

    for HBeAg

    an d

    HBsAg,

    bu t

    positive

    for

    HBsAb and

    IgG

    HBcAb.

    Which

    of the following is the

    appropriate

    conclusion?

    The

    patient

    has been

    exposed

    to

    hepatitis

    B

    and has

    completely

    recovered.

    B.

    The

    patient

    has

    been

    exposed

    to

    hepatitis

    B

    an d is

    in

    the acute disease

    phase.

    C.

    The

    patient

    has been

    exposed

    to

    hepatitis

    B

    an d

    is in

    the window

    phase.

    D.

    The

    patient

    ha s

    been

    exposed

    to

    hepatitis B

    bu t was not

    infected.

    E.

    Th e

    patient

    has been

    exposed

    to

    hepatitis

    B

    and is now chronically

    infected.

    F.

    The

    patient

    ha s been successfully vaccinated for

    hepatitis

    B.

    An

    overweight, 46 year-old

    man has complained

    of heartburn

    for the

    past

    is

    pr

    ears.

    A photomicrograph from

    a

    biopsy

    of

    his lower esophagus

    vided. Which of

    the

    following

    is

    the most likely diagnosis?

    f

    Barrett

    esophagus

    Candida esophagitis

    C.

    herpes

    esophagitis

    D.

    Plummer-Vinson syndrome

    E.

    viral

    esophagitis

    A

    67 year-old woman

    has

    experienced

    severe

    nausea,

    vomiting,

    early

    satiety,

    and

    a

    9-kg weight

    loss over the

    past

    4

    months.

    On

    physical

    examination,

    she ha s mild muscle wasting.

    Upper gastrointestinal

    endoscopy shows

    that

    the

    entire gastric

    mucosa is eroded

    and erythematous.

    Upper

    gastrointestinal

    imaging

    studies reveal that the

    stomach is

    small

    and shrunken.

    Which

    of

    the following

    is most

    likely

    to

    tie

    founon

    histologic

    examination of a gastric biopsy

    specimen?

    jlffi

    chronic

    atrophic

    gastritis

    B.

    granulomatous

    inflammation

    t

    Q

    C.

    intestinal-type

    adenocarcinoma

    .

    parietal

    cell hyperplasia

    T

    V\r~*

    0

    signet-ring cell

    adenocarcinoma,

  • 8/11/2019 GI Summer Review -Answers- Bosch (2013)

    4/16

    2013

    Gl

    Summer

    Review;

    Barbara

    D.

    Bosch,

    M.D.

    page

    4

    Which

    one o f

    the

    following is

    most likely to be

    present

    within

    the

    smooth

    endoplasmic reticulum

    of

    hepatocytes?

    v

    --

    .

    albumin

    cholesterol

    _

    C. fibrinogen

    D.

    glycogen

    * ~'a

    E.

    hydrogen peroxide

    -

    lpcowitPWck

    t-Jr v\

    hemolytic

    anemia

    I

    ~

    pancreatic

    carcinoma

    lv

    I

  • 8/11/2019 GI Summer Review -Answers- Bosch (2013)

    5/16

    2013

    Gl

    Summer Review; Barbara

    D.

    Bosch,

    M.D.

    page 5

    In

    the

    accompanying photomicrograph

    of an H&E-stained

    tissue

    section,

    the

    structures

    indicated

    by

    arrows are which

    of

    the

    following?

    A.

    clusters

    of hepatocytes

    B.

    intralobular ducts

    C

    islets

    of Langerhans

    D.

    parasympathetic

    ganglia

    E.

    serous acini

    A

    19 year-old woman is

    bothered

    by

  • 8/11/2019 GI Summer Review -Answers- Bosch (2013)

    6/16

    2013 Gl Summer

    Review;

    Barbara D.

    Bosch,

    M.D. page

    6

    A

    45

    year-old

    woman

    presents

    with intermittent

    episodes

    of

    epigastric

    pain

    an d

    is found to have

    gallstones

    on ultrasound. However,

    she

    is no t

    jaundiced. During

    exploratory surgery, one stone

    is

    found to be

    obstructing

    a

    duct.

    In

    view of her

    symptoms,

    where is the most

    probable

    location of the

    obstruction?

    A. ampulla

    of

    \Zater~~p >

    0

    C.

    common

    heoatic duct

    .

    common

    hepatic

    duct

    D.

    cystic duct

    -t>duct

    of

    Santorini

    --

    x-rn

    Over the

    past 3

    months, a

    41 year-old man ha s

    noticed that h is

    skin

    has

    become progressively

    more

    ye llo w. O n physical exam,

    he

    is afebrile

    but has scleral icterus and

    generalized

    jaundice.

    Laboratory

    studies show

    a

    total

    serum

    bilirubin

    of 8.9 mg/dL

    (normal

    0.1-1.0

    mg/dL)

    with

    a

    direct bilirubin of 6.8

    mg/dL

    (normal

    0.0-0.3

    mg/dL).

    Serum

    ALT

    and AST levels

    are

    normal.

    A l iver biopsy

    shows

    histologic features

    of sclerosing cholangitis.

    Which

    of

    the following

    diseases

    is

    most

    likely

    to coexist

    with the liver

    disease?

    A. celiac

    sprue

    B.

    chronic pancreatitis

    C.

    Crohn

    disease

    D.

    diverticulosis

    ulcerative colitis

    A

    22

    year-old

    woman

    ha s

    ha d several

    episodes of aspiration

    of food

    associated with

    difficulty

    swallowing

    during the

    past

    year. A barium swallow shows markeoreiobhaaeal

    dilation

    abovS

    the

    leybl

    of

    thedower

    esophageal

    sphincteft

    A

    biopsy specimen

    from the lower esophagus shows an

    sence

    of

    the

    mventprir.

    gangTlgfTATHat

    js

    the

    most

    likely diagnosis?

    achalasia

    B.

    Barrett

    esophagus

    C.

    Boerhaave

    syndrome

    D.

    Plummer-Vinson

    syndrome

    E.

    Schatzki

    ring

    A

    55

    year-old

    man presents

    with general ized back

    pain. X-ray

    examination

    o f the

    spine reveals two wedged thoracic vertebrae,

    T7

    and T8.

    He

    is found to

    be anemic

    with a

    normal

    peripheral

    blood smear. However,

    examination of

    his bone marrow

    shows

    an

    increased

    number of

    the

    type

    of

    cells indicated

    by

    arrows

    in

    this

    photomicrograph of

    the

    small intestine.

    These cells

    synthesize

    which

    of the

    following?

    collagen

    B.

    heparin

    and histamine

    C. his taminase

    (> IgA

    E.

    myeloperoxidase

    A 3 week-old bo y

    presents

    to

    his pediatrician because

    his

    mother has noticed

    that

    he

    looks yellow .

    On

    questioning, she elaborates that

    the

    jaundice

    began several days

    after

    birth and has been

    associated with

    dark

    urine and

    acholic stools. Laboratory studies

    show

    a

    direct

    bilirubin

    leve l o f 5 .0

    mg/dL

    (normal

    0.0-0.3 mg/dL) and

    a

    total bilirubin

    level of 5.5 mg/dL

    (normal

    0.1-1.0

    mg/dL).

    Which

    of

    the

    following

    is the most likely diagnosis?

    \oMt\ihK\

    jQ/

  • 8/11/2019 GI Summer Review -Answers- Bosch (2013)

    7/16

    2013

    Gl Summer

    Review; Barbara D.

    Bosch,

    M.D.

    page

    7

    A 25

    year-old

    man with

    acquired

    immunodeficiency disease (AIDS)

    has

    malabsorption,

    chronic

    abdominal

    pain,

    low-grade

    fever,

    and

    nonbloody diarrhea.

    In

    fecal

    smears,

    large

    numbers

    of oocysts

    containing

    four

    sporozoites

    are

    observed.

    Which

    of the following

    organisms

    is

    the

    most

    likely

    etiologic

    agent?

    Cryptosporidium

    parrum

    / B.

    Entamoeba histolytica

    j

    C. Giardia lamblia

    \J

    D.

    Taenia

    solium

    E.

    Toxoplasma

    gondii

    A

    30

    year-old

    woman sees he r physician

    because she

    has had

    diarrhea

    an d

    fatigue,

    as

    well

    as a 3-kg

    weight

    loss over

    the

    past

    6 months.

    On

    physical

    examination,

    sh e

    is afebrile

    and has

    mild muscle

    wasting,

    but

    her

    motor

    strength

    is normal. Laboratory studies show no occult

    blood,

    ova

    or

    parasites

    in the

    stool.

    A biopsy

    specimen

    from

    the upper jejunum

    is

    obtained. The

    patient

    is

    placed

    on a

    special

    diet with

    no wheat

    or

    rye

    grain

    products.

    This

    dietary

    change produces

    dramatic

    improvement.

    Which of

    the following

    microscopic

    features was most likely seen on

    the

    biopsy

    specimen?

    A.

    crypt

    abscesses

    /

    B. foamy macrophages within the lamina

    propria

    I

    /

    C. lymphatic

    obstruction

    \y

    D.

    non-necrotizing

    granulomas

    villous

    blunting

    an d flattening

    A

    26

    year-old

    man

    has

    recently aten

    raw

    oystersjon

    three

    occasions1

    The

    patient

    ha s

    always

    been

    healthy,

    but now

    has the

    sudden onset of

    fatigue,

    loss of

    appetite,

    nausea,

    vomiting,

    abdominal

    pain,

    and fever. Which o f the following viral

    pathogens

    is

    most likely

    responsible

    for

    this

    clinical

    Presen,aj9~s

    /ff

    hepatitis B

    virus

    rotavirus

    A

    63

    year-old man

    who

    had worsening congestive

    heart

    failure with

    cardiac

    dysrhythmias in

    the last

    year of

    his

    life

    died

    of

    pneumonia.

    At

    autopsy,

    his

    pancreas

    is small an d hard.

    Microscopic

    examination shows

    extensive

    atrophy

    of the

    acini with abundant

    collagenous interstitial

    fibrosis,

    but

    the

    islets

    of Langerhans

    appear

    normal.

    Inspissated

    proteinaceous

    secretions

    are

    present

    in

    branches

    of the

    pancreatic

    duct.

    The

    heart

    weighs

    500

    g

    (normal

    300-350 g),

    and

    al l four chambers

    are dila ted. What

    condition is

    most

    likely to

    account for

    these

    findings?

    blunt trauma to the abdomen

    B.

    cholelithiasis

    t

    chronic alcoholism

    diabetes melli tus

    E. hypercholesterolemia

    A 42

    year-old

    woman

    has to

    undergo(emergency

    choiecystecto

    fo

    du e

    to

    intense

    surgery is indie

    wing

    arrows?

    $

    \

    .

    3

    /L

    T 4

    5

    'he

    structure to

    be

    removed during

    Accompanying radiograph

    by

    which of the

  • 8/11/2019 GI Summer Review -Answers- Bosch (2013)

    8/16

    2013

    Gl

    Summer

    Review;

    Barbara D

    Bosch,

    M .D. page

    8

    A

    full-term

    neonate

    presents to the

    pediatrician

    with failure

    to

    pass

    meconium.

    Digital examination

    of

    the rectum

    results

    in

    a gush

    of retained fecal material.

    Which of

    the

    following is the most

    likely

    diagnosis

    in

    this infant?

    carcinoma of the colon

    Chagas

    disease

    Hirschprung

    disease

    imperforate

    anus

    necrotizing

    enterocolitis

    of

    Plasma

    The figure to the

    right sh ows a

    gastric

    parietal

    cell with

    selected

    membrane transporters and

    channels.

    What

    do

    X,

    Y and Z

    represent?

    Y Z

    IT K+

    K* IT

    CI'

    hco3-

    Na+

    IT

    IT K+

    Prlliptrjt

    lll

    HCO-s

    atr

    Lume

    C. H

    D. K+

    E. Na+

    The

    symptoms

    of

    thiamine

    deficiency

    were

    first

    described

    over 4000

    years ago. In adults,

    these

    symptoms

    commonly

    include

    polyneuropathy

    of the

    distal extremities,

    resulting

    in

    paresthesias and

    motor dysfunction.

    In

    addition

    to neuropathy,

    how

    else can

    isolated

    thiamine

    deficiency

    present

    in

    adults?

    A.

    chronic infections

    .

    .

    diarrhea,

    dermatitis

    an d dementia

    C.

    Tjerirritability,

    seizures and

    jaundice

    peripheral

    edema an d congestive

    heart

    failure

    E.

    renal

    failure

    An obese

    43

    year-old white woman

    presents to

    the

    emergency

    department

    with

    right upper

    quadrant

    pain,

    fever and jaundice.

    Abdominal

    examination

    reveals

    right

    upper

    quadrant

    tenderness

    without

    peritoneal signs.

    Endoscopic

    retrograde

    cholangiopancreatography shows several stones

    in the

    common

    bile duct. Laboratory testing reveals a

    WBC

    count of

    14,200/mm3

    (normal

    4,500-

    11

    ,000/mm3),

    with

    74% segmented

    neutrophils,

    and a serum amylase level

    of 78 U/L

    (normal

    25-125

    U/L).

    Which

    of

    the

    following is the most likely

    diagnosis for

    this patient?

    A.

    acute

    appendicitis

    acute

    pancreatitis

    acute

    viral

    hepatitis

    bacterial

    cholangitis

    cholesterolosis

    .

    Recanalization

    of

    the bile duct

    after

    the 13th week

    of

    development

    allows

    for

    bile

    produced

    in

    the liver

    to

    reach the

    duodenum.

    However*juM

    C.

    midgut

    D. yfJIeuroperitoneal

    membrane

    /septum

    transversum

    5>

    I

  • 8/11/2019 GI Summer Review -Answers- Bosch (2013)

    9/16

    2013 Gl Summer

    Review;

    Barbara D.

    Bosch, M.D.

    page 9

    A 36

    year-old

    woman is

    in

    the sixth month

    of

    he r

    pregnancy,

    but she

    is

    unsure

    of

    her

    dates

    because

    she

    was taking

    oral

    contraceptives

    at

    the

    time sh e became

    pregnant.

    She

    experiences

    the

    sudden

    onset of severe

    abdominal

    pain.

    On

    physical

    exam,

    she is afebrile

    an d

    normotensive.

    There is right

    upper

    quadrant

    tenderness on

    palpation.

    An ult rasound scan of

    the abdomen shows

    a

    well-

    circumscribed,

    7-cm

    subcapsular

    hepatic

    mass. Paracentesis

    yields

    bloody fluid. At

    surgery,

    the

    mass

    in

    the

    liver,

    which has

    ruptured

    through

    the

    capsule,

    is

    removed. The

    remaining

    liver

    appears

    unremarkable.

    Which

    of

    the following is

    the

    most

    likely diagnosis?

    cholangiocarcinoma*

    3

    fibrolamellar

    hepatocellular

    carcinoma

    epatic

    adenoma

    osa

    hepatocellular

    carcinoma

    metastatic

    carcinoma

    testae.,

    \

    VvesfcH

    I

    C\r

    A

    32

    year-old

    man

    presents

    with diarrhea

    and

    symptoms

    of

    peptic

    ulcer disease. Endoscopy reveals

    two

    ulcers,

    one

    in

    the first

    portion

    of the duodenum and one in

    the

    mid-duodenum.

    However,

    they

    do

    not

    respond

    to the usual

    peptic

    ulcer

    treatment programs.

    The

    most likely

    explanation

    for

    the findings

    in

    this

    patient

    is which of

    the following?

    -autoantibodies

    to

    intrinsic

    factor

    ectopic

    hypersecretion

    of gastrin

    gastric mucosal

    atroohv

    _

    c.il

    Menetrier disease

    pressure

    ulceration from

    y.

    vascular

    abnormality

    A pathologist views the tissues

    in

    the

    accompanying photomicrographs

    in

    a

    biopsy

    specimen.

    She determines that

    the tissues are

    normal. The

    presence

    of

    both of these

    tissues indicates

    that

    the

    sample

    was

    taken from

    the

    region

    of the

    junction between

    which of the

    following?

    Ar mouth

    and

    esophagus

    /

    esophagus

    and

    stomach

    itomach

    and duodenum

    Ileum

    an d colon

    rectum an d anus

    A

    Syarlold

    manjresents

    to the

    clinic with

    ffieral

    icterusipatosplenomegaly$|scites>and

    a

    history

    of

    episodes

    of

    feundice

    over'the oast

    th'fgg vear&7

    He

    was involved

    in

    an

    auto

    accident

    when

    A

    LTrVteT

    he

    was

    21,

    fo r which he

    req

    u

    i

    re

  • 8/11/2019 GI Summer Review -Answers- Bosch (2013)

    10/16

  • 8/11/2019 GI Summer Review -Answers- Bosch (2013)

    11/16

    2013

    Gl

    Summer

    Review;

    Barbara

    D.

    Bosch, M.D. page 11

    A 56

    year-old man

    who is a health care

    worker

    presents

    to his

    physician

    with

    vague

    abdominal

    discomfort.

    A

    physical

    examination reveals a tender

    liver,

    palpable

    to

    6

    cm

    below

    the

    costal

    margin,

    and

    scleral icterus. His laboratory

    studies are significant

    for

    an

    aspartate

    aminotransferase (AST)

    level

    of

    20 0 U/L

    (normal

    8-20

    U/L),

    an

    alanine

    aminotransferase

    (ALT)

    level

    of

    450 U/L

    (normal

    8-20

    U/L),

    an d an alkaline

    phosphatase

    level of 24 5

    U/L

    (normal

    20-70

    U/L).

    A

    CT scan

    of the abdomen

    shows a dominant solid

    nodule

    in

    the liver. The tumor

    marker

    mjst

    likely to be

    elevated

    in

    this patient

    is

    also

    agobd

    indicator

    of

    which

    of the

    following malignancies?

    Sh.

    choriocarcinoma

    .

    //

    colorectal carcinoma

    clSK

    SCuroZstoma

    QtU,

    prostatic

    carcinoma

    -V-n

    n

    .

    Vo,k

    sac

    tUmor

    yf

    A

    28 year-old

    recently

    divorced man with

    no significant

    past

    medical history

    presents

    with progressive

    lower

    abdominal

    pain

    and cramping over

    the

    past

    4

    days,

    which are

    relieved

    by

    defecation.

    He

    has

    uVir

    suffered

    from

    substantigkgTooand

    mucoid

    diarrhea\jiring

    th'g

    time.

    His

    temperature

    is

    Lab

    studies

    reveal

    arylevited

    WBC

    courSt

    and'tgiTerythrocyte

    sedimentation

    Sigmoidoscopy

    reveaWextensrveTectaTand sigmoid hyperemia

    aTid

    edema,

    numerous

    superficial

    ulcerations,

    an d

    small focal mucosal

    hemorrhages, many

    of which have

    suppurative

    centers. These

    B.

    Crohn disease

    C.

    cytomegalovirus

    enterocolitis

    hP&

    9*0

    A

    pseudomembranous

    colitis

    -erative

    colitis

    A

    30

    year-old

    man seeks

    help

    because

    heJ]tesLiLrfeels(full

    afterating55lcsmal>

  • 8/11/2019 GI Summer Review -Answers- Bosch (2013)

    12/16

    2013 Gl Summer Review;

    Barbara

    D.

    Bosch.

    M.D.

    page

    12

    A 39 year-old woman

    presents

    with

    dyspnea,

    fatigue,

    pallor,

    and

    tachy

    cardia.

    Laboratory results reveal

    a

    hematocrit of

    32 %

    (normal

    36-44%),

    a red cell mean

    corpuscular

    volume of

    102

    fL (normal

    78-98

    fL),

    and a

    vitamin

    B12

    level of

    95

    pg/mL (normal

    200-900

    pg/mL) due to impaired

    absorption.

    Autoantibodies are

    detected

    to a cell

    type

    which

    produces

    intrinsic

    factor.

    Referring

    to the

    accompanying

    diagram,

    in

    which

    region

    woulft

    those

    cells be

    found?

    V

    A 44 year-old

    woman

    has noticed

    increasingly

    severe

    fatigue

    an d generalized

    pruritus

    for

    the past

    8

    months. Serum levels

    of

    alkaline

    phosphatase

    and cholesterol are elevated;

    antimitochondrial

    antibody titer

    is

    elevated, bu t

    ANAs are

    no t present.

    The

    serum

    total

    bilirubin

    concentration

    is

    slightly

    elevated.

    A

    l iver biopsy

    is

    performed

    revealing granulomatous

    destruction of

    small

    intrahepatic

    bile

    ducts.

    Which

    of

    the

    following

    conditions

    is most

    likely?

    _

    A.

    autoimmune

    hepatitis

    B.

    choledocholithiasis

    'n.rve'W.r.oA

    ft*

    C.

    hepatitis B

    primary biliary

    cirrhosis

    E. primary sclerosing

    cholangitis

    F.

    Wilson

    disease

    w

    VA

    A

    66

    year-old

    man

    presents with

    a 3-month

    history of intermittent

    dysphagia

    that ha s

    now

    become

    constant

    an d

    is

    accompanied

    by

    pain and

    weight

    loss.

    X-rays

    of

    the

    esophagus

    with barium

    swallow

    show

    structural and

    filling defects,

    and reduced

    peristalsis.

    A

    biopsy is

    taken, f rom which

    a

    representative

    photomicrograph

    is

    provided.

    The

    best

    diagnosis

    is which of the

    following?

    fd'

    adenocarcinomaCTT0*9

    -

    BrBarrett

    esophagus

    ~

    Candida

    esophagitis

    fibrous

    stricture

  • 8/11/2019 GI Summer Review -Answers- Bosch (2013)

    13/16

    2013

    Gl

    Summer

    Review;

    Barbara

    D.

    Bosch,

    M.D. page

    13

    inaseVsefes

    -

    **#*&*

    >,&

    1>.

    .

    J

    .

    v Iv

    r- '

    r

    -

    C-Jysozyme

    mucus

    an d

    HCOV

    pepsinogen

    A

    52

    year-old

    woman is

    referred to

    a

    gastroenterologist

    for

    persistent

    abdominal

    is

    performed.

    of normal

    tissue

    structures

    A.

    B.

    enterokina;

    An 1

    8

    year-old

    woman

    presents

    with

    a

    one-week history

    of

    fever

    an d

    malaise>She

    has

    mild

    jaundice

    and a

    (ffightly

    Hemoglobin

    is

    13.8 g/dL

    (normaM3M(fg/dL);

    WBC count is

    13,000/mm

    (normal

    4,500-1

    1,000/mm3).

    SeruiTLJubinJs

    mg/dL

    (normal

    0.1-1.0

    mg/dl_)

    an d is 95% unconjugated

    bilirubinLiver

    enzyme

    tests

    arenona

    Which

    of

    the following

    is

    the most likely cause

    of this

    patient's

    signs

    an d

    symptoms?

    jC

    alcohol

    abuse

    c\

    decreased

    glucuronyl

    transferase

    hemolysis

  • 8/11/2019 GI Summer Review -Answers- Bosch (2013)

    14/16

    2013 Gl Summer

    Review;

    Barbara

    D

    Bosch,

    M.D page 14

    Jaundice caused

    by common

    bile

    duct obstruction is usually

    characterized

    by

    which o f the

    following

    laboratory

    findings?

    Urine Urine

    Bilirubin Urobilinogen

    A.

    t

    B. T

    -gP

    T

    D.

    Normal

    E.

    Normal

    F.

    Normal

    T

    Normal

    1

    t

    Normal

    i

    A

    13

    month-old child is brought to

    the emergency department

    after

    his

    parents

    found blood

    in his

    stool.

    They

    state

    that

    he did

    no t

    appear

    distressed

    at the time,

    although

    he

    now displays

    some

    tenderness

    to

    abdominal

    pressure.

    Other

    than

    this

    tenderness,

    there

    are

    no significant findings

    on

    physical

    examination. After performing

    radionuclide imaging using

    mTc

    pertechnetate,

    the

    doctor

    makes a d iagnos is and

    recommends

    surgery

    to correct the problem. What

    is

    the probable source of

    this child's

    condition?

    A.

    blockage of the intestine

    du e

    to folding

    of the

    distal ileum into the

    proximal

    colon

    B. breakdown of

    the gastric

    mucosal

    barrier with

    erosion

    of

    the

    underlying

    mucosa

    damage

    to the

    intestinal

    epithelium

    due to ingestion of

    coins

    ectopic

    gastric

    epithelium

    in a

    persistent omphalomesenteric

    duct

    E.

    incomplete bowel

    rotation

    resulting

    in obstruction of

    the

    superior

    mesenteric artery

    A 2

    year-old girl

    with

    a

    lifelong

    history of malabsorptive

    an d

    foul-

    smell ing diarrhea,

    weakness an d

    general

    failure

    to thrive

    has

    just

    undergone

    a sma ll

    intestine biopsy

    (see

    accompanying

    photomicro

    graph).

    Her

    parents

    believe

    her problems began

    at 6 months of

    age,

    when

    she

    started

    eating

    solid

    foods, but have significantly

    worsened

    over

    the

    past few

    months.

    The only recent

    change in her

    diet

    is

    that she

    eats a

    bowl o f cereal

    every

    morning

    with

    her parents

    before

    they

    go

    to work.

    Sh e

    tried a dairy-free

    diet

    a

    month

    ago,

    bu t

    it did not improve

    her

    symptoms.

    Which

    of

    the

    following

    js

    the

    likely

    diagnosis?

    /yA.

    abetalipoproteinemia

    /

    >.

    celiac

    disease

    cystic fibrosis

    pQ-

    lactase

    deficiency

    viral

    enteritis

    F/Vhipple

    disease

    1

    'mmm

    '

    'MS

    s :v

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    15/16

    2013

    Gl Summer

    Review;

    Barbara D. Bosch,

    M.D.

    page

    15

    A

    healthy volunteer received a

    continuous

    infusion

    of physiological

    gastrin

    concentrations before an d after treatment

    with

    peptide X.

    The

    production

    of

    gastric

    acid an d

    pancreatic

    bicarbonate

    secretion

    was

    monitored before an d after administration of

    peptide

    X

    (at

    arrow).

    Peptide X

    is

    most likely to

    have been which

    of

    the

    following

    hormones?

    angiotensin

    II

    cholecystokinin

    motilin

    secretin

    somatostatin

    Last':

    =sf;i

    Js i

    FfcMhc

    HCDj

    B.

    C.

    E.

    aarc*Mlc

    HZO

    unrc

    H

    I r~

    i

    l

    Qutotfl :

  • 8/11/2019 GI Summer Review -Answers- Bosch (2013)

    16/16

    2013 Gl Summer

    Review;

    Barbara

    D.

    Bosch,

    M.D.

    page

    16

    A 23

    year-old

    man

    has been

    complaining

    of

    intermittent

    diarrhea,

    fever and

    abdominal pain for

    several

    months. A radiograph

    of

    the

    small

    bowel

    reveals

    several

    separatg_areas

    of

    luminal

    narrowing.

    A

    photomicrograph

    of this

    patienVCiieal

    bfopsy

    is shown.

    What

    is

    the

    most

    likely

    diagnosis?

    -r

    abetalipoproteinemia

    tvlvAvH

    carcinoid

    tumor

    A.

    B.

    E.

    F.

    celiac disease

    Crohn

    disease

    ulcerative

    colitis

    Whipple

    disease

    ,r>;

    /'

    l

    r

    .


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