GIULIO CAVALLI Country: Italy Country of origin: Italy Contact e-mail: cavalli.giulio@hsr.it Year of birth: 1986 Mains diplomas: MD San Raffaele University, Milan; 2011 Allergy and Clinical Immunology San Raffaele University, Milan; 2016 PhD Radboud University, Nijmegen, The Netherlands; expected completion 2018 Current position and current hospital/university: Attending Physician, IRCCS San Raffaele Hospital, Milan, Italy Lecturer, Vita-Salute San Raffaele University, Milan, Italy Position within EULAR/international experience: EMEUNET Working group member, 2017 FDIME Awardee, 2016 Postdoctoral Researcher, University of Colorado, Denver, CO, 2014-2016 Researcher, Sanford-Burnham Medical Research Institute, La Jolla, CA, 2010 Volunteer, St. Mary’s Lachor Hospital, Gulu, Uganda, 2009 Volunteer, Sao Marcos Hospital, San Salvador de Bahia, Brazil, 2008 Role as EMEUNET working group member: Social Media Subgroup Areas of Research/Interest: Anti-inflammatory cytokines and molecules; IL-1-mediated inflammation; Genetic risk of developing autoimmunity; Rare and orphan diseases Keywords: Interleukin, cytokine, IL-1, IL-37, inflammation, metabolism, HLA Selected Publications:

1. Cavalli G, Justice JN, Boyle KE, D’Alessandro A, Eisenmesser EZ, Herrera JJ, Hansen KC, Nemkov T, Stienstra R, Garlanda C, Mantovani A, Dagna L, Seals DR, Joosten LAB, Ballak DB and Dinarello CA. Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration and improves exercise tolerance. Proc Natl Acad Sci U S A. 2017

2. Cavalli G, Hayashi M, Jin Y, Yorgov D, Santorico SA, Holcomb C, Rastrou M, Erlich H, Tengesdal IW, Dagna L, Neff CP, Palmer BE, Spritz RA, Dinarello CA. MHC class II super-enhancer increases surface expression of HLA-DR and HLA-

DQ and affects cytokine production in autoimmune vitiligo. Proc Natl Acad Sci U S A. 2016

3. Cavalli G, Dinarello CA. Treating rhematological diseases and comorbidities with Interleukin-1 blocking therapies. Rheumatology (Oxford). 2015

4. Diamond EL, Dagna L, Hyman DM, Cavalli G, Janku F, Estrada-Veras J, Ferrarini M, Abdel-Wahab O, Heaney ML, Scheel PJ, Feeley NK, Ferrero E, McClain KL, Vaglio A, Colby T, Arnaud L, Haroche J. Consensus Guidelines for the Diagnosis and Clinical Management of Erdheim-Chester Disease. Blood. 2014

5. Cavalli G, Guglielmi B, Berti A, Campochiaro C, Sabbadini MG, Dagna L. The multifaceted clinical presentations and manifestations of Erdheim-Chester disease: comprehensive review of the literature and of 10 new cases. Ann Rheum Dis. 2013

Date of last update of the CV: September 2017