2018
The 9th PKU-UC Davis plus
Bilateral Symposium of the
10+10 Alliance
Global Frontiers in Chemistry
and Chemical Biology
Beijing, P. R. China
May 12-15
Organized by
College of Chemistry and Molecular Engineering, PKU
Center for Soft Matter Science and Engineering, PKU
Key Laboratory of Polymer Chemistry & Physics of the
Ministry of Education, PKU
第9届中美10+10双边研讨会
Symposium Program
Monday, May 14, 2018
08︰00-08︰30 Registration (CCME)
08︰30-09︰00 Opening Ceremony and Photo Time.
Chair: Prof. Wen-Bin Zhang & Prof. Peter Kelly
Speakers: Prof. Yiqin Gao, Prof. Yuguo Ma,
Prof. Alexandra Navrotsky
Group Photo at the Lobby of Building A of CCME
09︰00-12︰05 Lectures (CCME Central Multifunctional Room)
Time Lectures
Chair Prof. Peng Chen
09:00-09:25 Alexandra Navrotsky, UC-Davis, (IL-01)
Thermochemical studies of metal organic frameworks
09:25-09:50 Li-Tang Yan, Tsinghua University, (IL-02)
Transport of Two-Dimensional Nanomaterials Sandwiched inside Cell Membrane
09:50-10:15 Kristie Koski, UC-Davis, (IL-03)
Chemically tunable 2D Materials
10:15-10:35 Student Posters’ Elevator Pitch (P-1 to P-5, 3 min each)
10:35-10:50 Coffee Break & Poster & Discussions
Chair Prof. Gang-yu Liu
10:50-11:15
Jared T. Shaw, UC-Davis, (IL-04)
New Stereoselective Reactions of Rhodium Carbenes for the Assembly of Complex Organic
Molecules
11:15-11:40 Yongquan Qu, Xi’an Jiaotong University, (IL-05)
Surface Regulations of CeO2 for Heterogeneous Catalysis
11:40-12:05 Davide Donadio, UC-Davis, (IL-06)
Characterization of the surface of ice: an atmospheric chemistry catalyst
12︰05-14︰00 Lunch and discussions (CCME A917)
14︰00-17︰15 Lecture (CCME Central Multifunctional Room)
Time Lectures
Chair Prof. Wen-Bin Zhang
14:00-14:25 Shu Wang, ICCAS, (IL-07)
Conjugated Polymer-Based Assembly Materials for Biomedical Applications
14:25-14:50 James Link, Princeton, (IL-08)
Mining Genomes for Lasso Peptides
14:50-15:15 Hua Lu, PKU, (IL-09)
Macrocyclization of Site-Specific Protein-Poly(α-amino acid) Conjugates
15:15-15:35 Student Posters’ Elevator Pitch (P-6 to P-10, 3 min each)
15:35-16:00 Coffee Break & Poster & Discussions
Chair Prof. Peter Kelly
16:00-16:25 Guoqiang Yang, ICCAS, (IL-10)
Organic boron compounds as novel fluorescent probes
16:25-16:50 Matthew P. Augustine, UC-Davis, (IL-11)
Using Mobile NMR Spectroscopy to Study Chemical Problems in a Factory Environment
16:50-17:15 Wen-Bin Zhang, PKU, (IL-12)
Genetically Encoded Click Chemistry: New Tools for Protein-based Materials
18︰00-20︰00 Banquet
Tuesday, May 15, 2018
08︰30-12︰15 Lecture (CCME Central Multifunctional Room)
Time Lectures
Chair Prof. Hua Lu
08:30-08:55 Peng Chen, PKU, (IL-13)
Bioorthogonal Cleavage Reactions in Living Systems
08:55-09:20 Sheila S. David, UC-Davis, (IL-14)
The Secret Life of the Genome: Repair of DNA base modifications
09:20-09:45 Guifang Jia, PKU, (IL-15)
Reversible RNA Adenosine Methylation in Plant Biological Regulation
09:45-10:10 Annaliese Franz, UC-Davis, (IL-16)
Sustainable Production of Biofuels and Bioproducts from Microalgae
10:10-10:30 Student Posters’ Elevator Pitch (P-11 to P-14, 3 min each)
10:35-10:50 Coffee Break & Poster & discussions
Chair Prof. Sheila S. David
10:50-11:15 Dehai Liang, PKU, (IL-17)
Non-equilibrium protocell models with “living” features
11:15-11:40 Kyle N. Crabtree, UC-Davis, (IL-18)
Microwave spectroscopy for chemical kinetics and laboratory astrophysics
11:40-12:05 Ting Guo, UC-Davis, (IL-19)
Energy Transfer in the X-ray Regime: X-ray Induced Energy Transfer (XIET)
12︰15-14︰00 Lunch and Discussions (CCME A917)
14︰00-17︰15 Lecture (CCME Central Multifunctional Room)
Time Lectures
Chair Prof. Peng Zou
14:00-14:25 Xuefeng Guo, PKU, (IL-20)
Single-Molecule Electrical Detection
14:25-14:50 Wei Xiong, UCSD, (IL-21)
Ultrafast Direct Electron Transfer at Organic Semiconductor and Metal Interfaces
14:50-15:15 Ying Jiang, PKU, (IL-22)
Probing interfacial water at submolecular level by scanning probe microscopy
15:15-15:35 Student Posters’ Elevator Pitch (P-15 to P-17, 3 min each)
15:35-16:00 Coffee Break & Poster & Discussions
Chair Prof. Kyle N. Crabtree
16:00-16:25 Gang-yu Liu, UC-Davis, (IL-23)
New Advances in 3D Nanoprinting
16:25-16:50 Peng Zou, PKU, (IL-24)
Hybrid Voltage Indicators for Imaging Neural Activity
16:50-17:15 Peter B. Kelly, UC-Davis, (IL-25)
Chemistry of atmospheric particles
16︰50-17︰10 Poster Award & Closing Remarks
Prof. Wei Xiong (UCSD to host next 10+10 in 2020)
Prof. Peng Zou (next PKU organizer)
18︰00-20︰00 Dinner
Student Posters
Number Presenter & Title
May 14, 2018, Morning Session
P-1 Wei Tang, Spatially specific RNA profiling via Chromophore-assisted proximity tagging (CAP-tag)
P-2 Jinsong Yuan, Salt- and pH-Triggered Helix−Coil Transition of Ionic Polypeptides under Physiology
Conditions
P-3 Yajie Liu, Tuning SpyTag-SpyCatcher reaction toward orthogonal reactivity encryption
P-4 Yongxian Xu, Hybrid Indicators for Fast and Sensitive Voltage Imaging
P-5 Pengfei Jin, Janus [3:5] polystyrene-polydimethylsiloxane star polymers with a cubic core
May 14, 2018, Afternoon Session
P-6 Wenhao Wu, Topology engineering of proteins in vivo using SpyX interlocking modules
P-7 Ruixuan Wang, Local Transcriptome Analysis via Chemical Activated Proximity-specific Ribosome
Profiling
P-8 Guangzhong Yin, Synthesis of water-soluble and clickable fullerene derivatives: Ready access to C60-
Protein conjugates
P-9 Yuguang Chen, Self-Divided Droplets on Liquid Surface
P-10 Zhongyu Zou, Analysis of Transcriptome on the Spatial and Temporal Dimensions
May 15, 2018, Morning Session
P-11 Lianhuan Wei, The m6A Reader ECT2 Controls Arabidopsis Trichome Morphology by Affecting mRNA
Stability
P-12 Xiaodi Da, Concise synthesis of protein heterocatenanes via “active template” strategy
P-13 Nan Chen, Chemical Proteomic Profiling of N-homocysteinylation with a Thioester Probe
P-14 Han Wu, Tiling Structures from Shape Amphiphiles
May 15, 2018, Afternoon Session
P-15 Chenmaya Xia, Non-blinking single molecule detection in a carbon nanotube by surface-enhanced
raman scattering
P-16 Wei Chen, Enrichment and detection of low-abundance mutations based on an artificial specific
endonuclease
P-17 Yu Shao, Synthesis and self-assembly of tri-block shape amphiphile regio-isomers
P-18 Yuxin Fang, Glycosylase Engineering for The Detection of Oxidative Lesions in DNA (Poster only)
P-19 Yi Li, Proximity-dependent labeling in yeast cell via engineered ascorbate peroxidase II (Poster only)
P-1 to P-10 are displayed on May 14, 2018; P11-P19 are displayed on May 15, 2018.
IL-01
Thermochemical studies of metal organic frameworks
Alexandra Navrotsky
Peter A. Rock Thermochemistry Laboratory, University of California Davis
Abstract
The thermodynamic stability of new hybrid organic-inorganic materials, including
metal organic frameworks (MOF) and hybrid perovskites for solar applications must be
known to assess their long-term behavior in use. Recent acid solution calorimetric
studies in our laboratory have emphasized MOF polymorphs and hybrid halide
perovskites. A series of MOF polymorphs prepared by grinding confirms that the
energetics depend on the molar volume and mechanochemical treatment enables
transformation barriers to be overcome, producing a sequence of denser and more stable
phases. We are studying their vibrational density of states by cryogenic heat capacity
measurements and inelastic neutron scattering. Hybrid halide perovskites are of limited
thermodynamic stability, not just for reaction with water and air but with respect to
intrinsic decomposition; thus, tetramethylammonium lead iodide can spontaneously
disproportionate to tetramethyl ammonium iodide and lead iodide. Introducing
organic layers to form 2D perovskites aids stability, but there are thermodynamic limits
to the number of perovskite layers that can be incorporated.
Biography
Dr. Alexandra Navrotsky’s research focuses on relating atomic-
level structure and bonding characteristics to macroscopic
thermodynamic behavior in minerals, ceramics and other complex
materials. Advancing high- and low-temperature reaction
calorimetry as a research tool, she has contributed to a broad
spectrum of applications, from mineral thermodynamics to
ceramic processing to zeolites. She has published more than 880
scientific papers. Dr. Navrotsky has received many top honors, including the Benjamin
Franklin Medal in Earth Sciences, the Harry Hess Medal, the Goldschmidt Medal, and
the Kingery Award. She serves on numerous advisory committees and panels in
government and academia, promoting interdisciplinary and collaborative research.
IL-02
Transport of Two-Dimensional Nanomaterials Sandwiched inside
Cell Membrane
Li-Tang Yan
Department of Chemical Engineering, Tsinghua University, Beijing 100084, China
Abstract
The transport of nanoparticles at the bio-nano interfaces is essential for many cellular
responses and biomedical applications. How two-dimensional nanomaterials, such as
graphene and transition-metal dichalcogenides, diffuse along the cell membrane is,
however, unknown, posing an urgent-important issue to promoting their applications in
biomedicine. Here we show experimentally and theoretically that the diffusive transport
of graphene nanosheets (GNs) sandwiched inside cell membrane varies from Brownian
dynamics to Lévy walks and even directional motion. Specifically, experiments
evidence the sandwiched graphene-cell membrane superstructures predicted by
simulations. Combined simulations and experiments identify sandwiched-GN-induced
pore in the leaflets of cell membrane, spanning unstable, metastable, and stable states.
Analytical model that rationalizes the regimes of these membrane-pore states fits the
simulations quantitatively, leading to a mechanistic interpretation of the emergence of
Lévy and directional dynamics. Our findings inform approaches to program
intramembrane transport of two-dimensional nanomaterials, and suggest design
principles for novel composite systems integrating such emerging nanomaterials inside
biological membranes.
Biography
Prof. Li-Tang Yan obtained his PhD in polymer physics and
chemistry at Tsinghua University in 2007. Then he went to
Bayreuth University in Germany as a Humboldt Research
Fellowship. In 2010, he joined Prof. Anna Balazs’ group at
University of Pittsburgh in USA as a Postdoctoral Research
Fellowship. He returned to Tsinghua University as a faculty in
Department of Chemical Engineering from May 2011. In 2014,
he obtained the “NSFC Award” for Excellent Young Scholar.
His research interests focus on computational and theoretical
aspects of soft matter systems, including nanoparticle cellular
interactions and nano-engineer materials that are self-assembling and self-regulating.
IL-03
Chemically tunable 2D Materials
Kristie J. Koski
Department of Chemistry, University of California Davis, Davis CA USA 95616
Abstract
Two-dimensional (2D) materials, such as layered chalcogenides, graphene, and oxides,
are an exciting new class of materials with extraordinary physical and chemical
behaviors. These high-performance materials have the potential to enable an entire fleet
of new technological applications ranging from electronics to photonics. To realize this
potential requires (i) the synthesis of novel, high-quality 2D materials, (ii) a broad
spectrum of chemical modification techniques, and (iii) a thorough understanding of
how these modifications control the material physics. In this presentation, I will show
new synthetic growth methods to create high-quality 2D chalcogenide materials
including a new semiconductor, Si2Te3. I will present a novel chemical method to
reversibly intercalate and deintercalate high concentrations of multiple, zero-valent
atoms into 2D materials. The zero-valent nature of the intercalant species allows for
high-density intercalation of metal atoms (Ag, Au, Co, Cu, Fe, In, Ni, and Sn)
effectively doubling the number of atoms of the material. This method achieves unique
physics including Pokrovsky-Talapov transitions, sliding charge density waves, and
modified phononic behaviors. Finally, I will show how this work achieves opto-
electronic application such as color-changing Smart Materials.
Biography
Dr. Kristie J Koski graduated from the University of
Wyoming in 2002 with a B.S. in Physics and a B.S. in
Chemistry. She attended graduate school at the University of
California: Berkeley followed by a postdoctoral position at
Arizona State University and a second position at
Stanford University. Her research currently focuses on 2D
materials and on Brillouin spectroscopy. Dr. Koski has
received the NSF CAREER Award and is funded by the
Office of Naval Research. When not doing science, Professor
Koski is an adrenaline junky known for surfing massive
waves, rock-climbing, and driving her over-powered muscle car way too fast.
IL-04
New Stereoselective Reactions of Rhodium Carbenes for the
Assembly of Complex Organic Molecules
Jared T. Shaw
Department of Chemistry, University of California, Davis, CA, USA
Abstract
Rhodium complexes catalyze the reactions of a wide variety of metal carbenes. We
have discovered that carbenes that lack electron-withdrawing groups, also known as
“donor/donor” carbenes, exhibit unique reactivity for enantioselective catalysis. We
have used this strategy for the synthesis of variety of 5- and 6-membered ring
products that are useful for the synthesis of drug discovery lead molecules and natural
products.
Biography
Jared Shaw received his B.S. in chemistry from UC
Berkeley (1993), during which time he conducted
undergraduate research with Prof. Clayton
Heathcock. After working as an associate at Gilead
Sciences for one year, Jared entered the Ph.D.
program at UC Irvine and worked with Prof. Keith
Woerpel, graduating in 1999. Jared then moved to
Harvard as an NIH postdoctoral fellow with David
Evans. Dr. Shaw became an institute fellow at the
Institute for Chemistry and Cell Biology (ICCB) at
Harvard Medical School in 2002 where he helped
found the Center for Chemical Methodology and
Library Development (CMLD) in 2003, which later
became part of the Broad Institute of Harvard and
MIT. In July of 2007, Jared joined the faculty of the University of California, Davis
as an assistant professor. He was promoted to associate professor in 2012 and to full
Professor in 2016. He currently works on the development of new methods for the
synthesis of natural products and other complex molecules that modulate biological
phenomena, with a specific emphasis on the discovery of new compounds with the
potential to become antibiotics to treat infections that are resistant to current therapies.
IL-05
Surface Regulations of CeO2 for Heterogeneous Catalysis
Yongquan Qu*
Center for Applied Chemical Research, Frontier Institute of Science and Technology, Xi’an
Jiaotong University, Xi’an, 710049, P. R. China
Abstract
Ceria (CeO2) as a support, additive, and active component for heterogeneous catalysis
has been demonstrated with the great catalytic performance, which includes the
excellent thermal structural stability, catalytic efficiency, and chemoselectivity.1,2 In
general, the reversible Ce3+/Ce4+ redox pair and the surface acid-base properties
contribute to the superior intrinsic catalytic capability of CeO2, and hence yield the
enhanced catalytic phenomenon in many reactions. Particularly, nanostructured CeO2
is characterized by a large number of surface-bound defects, which are primarily
oxygen vacancies, as the surface active catalytic sites. Many efforts have therefore been
made on controlling the surface defects and properties of CeO2 by various synthetic
strategies and post-treatments. In this talk, I will give a brief overview of our efforts on
the surface regulations of CeO2 by wet chemical redox etching3 and synthetic pressure4
as well as their catalytic applications.5-7 The strong electronic metal-support
interactions between the metal and CeO2 with the abandant surface defects of oxygen
vacancy enable high catalytic activity and chemoselectivity for hydrogenation of
nitroarenes8 and quinolines9 and C-C coupling reaction.10
References
(1) J. Paier, C. Penschke, J. Sauer, Chem. Rev. 2013, 113, 3949.
(2) Y. Ma, G. Wei, Z. Y. Zhang, S. Zhang, Z. Tian, Y. Liu, J. C. Ho, Y. Qu, Surf. Sci.
Rep. 2018, In Press.
(3) W. Gao, Z. Zhang, J. Li, Y. Ma, Y. Qu, Nanoscale, 2015, 7, 11686.
(4) J. Li, W. Gao, Z. Zhang, S. Zhang, Y. Ma, Y. Qu, ACS App. Mater. Interfaces, 2016,
8, 22988.
(5) J. Li, Z. Tian, Z. Zhang, X. Zhou, Z. Zheng, Y. Ma, Y. Qu, J. Mater. Chem. A 2014,
2, 16459.
(6) Z. Tian, J. Li, Z. Zhang, W. Gao, X. Zhou, Y. Qu, Biomaterials, 2015, 59, 116.
(7) S. Zhang, Z. Q. Huang, Y. Ma, W. Gao, J. Li, F. X. Cao, L. Li, C. R. Chang, Y. Qu,
Nature Commun. 2017, 8, 15266.
(8) S. Zhang, C. R. Chang, Z. Q. Huang, J. Li, Z. Wu, Y. Ma, Z. Zhang, Y. Wang, Y. Qu,
J. Am. Chem. Soc., 2016, 138, 2629.
(9) S. Zhang, Z. Xia, T. Ni, Z. Zhang, Y. Ma, Y. Qu, J. Catal., 2018, In press.
(10) S. Zhang, C. R. Chang, Z. Q. Huang, Y. Ma, W. Gao, J. Li, Y. Qu, ACS Catal.,
2015, 5, 6481.
Biography
Yongquan Qu received his B.S. from Nanjing University at 2001,
M.S. from Dalian Institute of Chemical Physics at 2004 and Ph.D.
from the University of California, Davis under the supervision of
Prof. Ting Guo at 2009. He moved to the University of California,
Los Angeles for the postdoctoral training with Prof. Xiangfeng
Duan in Department of Chemistry and Biochemistry. He became
a faulty member of Center for Applied Chemical Research,
Frontier Institute of Science and Technology, Xi’an Jiaotong
University, China at 2012. His current research interests include
the heterogeneous catalysis in areas of organic synthesis, clean energy production and
environmental remediation.
IL-06
Characterization of the surface of ice: an atmospheric chemistry catalyst
Davide Donadio
Department of Chemistry, University of California, Davis, Davis, CA, 95616
Abstract
As Faraday realized by microscopic observations already in 1850, the surface of ice is
covered by a thin layer of liquid water even at temperatures far below melting. In spite
of the importance of ice surfaces in terrestrial and atmospheric physical and chemical
processes, the microscopic structure and dynamics of the disordered surface layer of
ice, commonly dubbed quasi liquid layer, is still largely unknown. In this work we use
classical and ab initio molecular dynamics simulations to characterize the structure and
dynamics of the quasi liquid layer at the low-index surfaces of hexagonal ice in the
temperature range that extends from 200 K to the melting temperature, and we
investigate how these properties are modified by the interaction with trace gasses or
ions. Our simulations identify a bilayer-by-bilayer discrete surface melting as a
function of temperature in pure ice models. Such melting behavior determines the shape
of the OH stretching band in infrared and non-linear sum frequency generation spectra
as a function of temperature. The adsorption of HCl induces further disordering at
stratospheric conditions. Ab initio MD simulations are combined with enhanced
sampling to discover the molecular mechanisms of ozone depletion reactions catalyzed
by the surface of ice.
Biography
Dr. Davide Donadio is a theoretical materials scientist. He earned
his Ph.D. in Materials Science in 2003 at the University of Milan
with a thesis on the optical and structural properties of silicate
glasses. As a postdoctoral fellow at ETH Zurich and UC Davis he
studied crystal nucleation and phase transitions, materials at
extreme conditions and nanoscale heat transport. From 2010 to
2015 he lead the Max Planck Research Group of “Theory of
nanostructures” at the MPI for Polymer Research (Mainz,
Germany), investigating non-equilibrium processes at the
nanoscale by molecular simulations. In 2014 he was appointed Ikerbasque professor at
the Donostia International Physics Center (San Sebastian, Spain) and in 2015 he
became assistant professor of Chemistry at UC Davis, where he continues his activity
on surface chemistry, energy materials, thermal transport and development of new
simulation methods. He has published 102 peer-reviewed articles and two book
chapters.
IL-07
Conjugated Polymer-Based Assembly Materials for Biomedical
Applications
Shu Wang*
Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
Abstract
In recent years, conjugated polymers (CPs) integrating recognition, imaging and therapeutic
functions have attracted more and more attention. A novel photodynamic therapy (PDT) system
was developed in which the photosensitizer is activated by chemical molecules instead of outer
light source. In this system, luminal, hydrogen peroxide and horseradish peroxidase (HRP)
were used as bioluminescent molecules and a cationic oligo (p-phenylene vinylene) (OPV) was
used as the photosensitizer. The excited OPV by BRET from luminol sensitizes oxygen
molecule in the surrounding to produce ROS that kill the adjacent cancer cells and pathogenic
microbes. The BRET system can work in vivo even in the deeper tissue, which comes over the
drawback of the deep tissue penetration for PDT with light irradiation. We designed an oligo(p-
phenylenevinylene) unit with thiol groups and a paclitaxelunit (OPV-S-PTX). The OPV-S-PTX
is capable of diffusing into cells, where π-π interactions lead to aggregation. Crosslinking of
the aggregates via oxidation of thiol groups preferentially occurs inside tumor cells because of
their higher internal reactive oxygen species (ROS) concentration. Crosslinked aggregates
effectively “chemically lock” the multichromophore particle inside the cells and this process
decreases the diffusion of the molecules out of the cell. The formation of the chemically locked
particles enhances drug efficacy and helps in reducing resistance. Recently, we have also
described a supramolecular antibiotic switch to reversibly “turn-on” and “turn-off” its
antibacterial activity, which provides a proof-of-concept to regulate antibacterial activity and
avoid accumulation of active antibiotics in the environment. The antibiotic switch relies on
supramolecular assembly and dis-assembly of cationic poly(phenylene vinylene) derivative
(PPV) with cucurbit[7]uril (CB[7]), which regulates their different interaction manners toward
bacteria. This supramolecular antibiotic switch could be a potential strategy to fight bacterial
infections and drug-resistance.
References
(1) H. Bai, H. Yuan, C. Nie, B. Wang, F. Lv, L. Liu, S. Wang, Angew. Chem. Int. Ed. 2015, 54,
13208.
(2) C. Nie, S. Li, B. Wang, L. Liu, R. Hu, H. Chen, F. Lv, Z. Dai, S. Wang, Adv. Mater. 2016,
28, 3749.
(3) Y. Wang, S. Li, L. Liu, F. Lv, S. Wang, Angew. Chem. Int. Ed. 2017, 56, 5308-5311.
S. Li, T. Chen,Y. Wang, L. Liu, F. Lv, Z. Li, Y. Huang, K. S. Schanze, S. Wang, Angew. Chem.
Int. Ed. 2017, 56, 13455-13458.
(4) S. Liu, H. Yuan, H. Bai, P. Zhang, F. Lv, L. Liu, Z. Dai, J. Bao, S. Wang, J. Am. Chem. Soc.
2018, DOI: 10.1021/jacs.7b12140.
(5) L. Zhou, F. Lv, L. Liu, G. Shen, X. Yan, G. C. Bazan, S. Wang, Adv. Mater. 2018, 30,
1704888.
(6) Y. Wang, S. Li, P. Zhang, H. Bai, L. Feng, F. Lv, L. Liu, S. Wang, Adv. Mater. 2018, 30,
1705418
Biography
Shu Wang is currently a professor of Key Laboratory of Organic
Solids, Institute of Chemistry, Chinese Academy of Sciences. He
earned his B.S. in Chemistry from Hebei University in 1994 and
his Ph.D. from Peking University in 1999. He was a postdoctoral
researcher at Institute of Chemistry, Chinese Academy of
Sciences from 1999 to 2001 and then at Institute of Polymers and
Organic Solids, University of California at Santa Barbara from
2001 to 2004. His current research interest is focused on design,
synthesis of optical functional organic conjugated molecules for
biosensors, cell imaging and disease therapeutics. He has
authored or co-authored more than 200 peer-reviewed articles, and is named in 30 patents or
disclosures. Now he is Executive Editor of ACS Applied Materials & Interfaces.
IL-08
Mining Genomes for Lasso Peptides
James Link
Department of Chemical Engineering & Bioengineering, Princeton University
Abstract
Lasso peptides are a class of ribosomally synthesized and post-translationally modified
peptides (RiPPs) with diverse bioactivities including antimicrobial activity, receptor
binding, and enzyme inhibition. As their name indicates, they are defined by their
unique threaded structure that resembles a lasso or a slipknot. This talk will describe
our work in genome mining for novel lasso peptides. We have developed new
algorithms to rapidly identify lasso peptides from sequenced genome, growing the class
of lasso peptides from a dozen examples in 2012 to several thousand predicted peptides
today. I will discuss our structural and functional studies on several new lasso
peptides. In particular, our lab has discovered a novel enzyme, lasso peptide
isopeptidase, which specifically recognizes the knotted structure of the lasso peptide
and cleaves it into a linear form. The role of this enzyme in the biological function of
lasso peptides will be discussed.
Biography
James Link grew up in Massachusetts. He attended Princeton
University as an undergraduate, earning a Bachelor’s of Science
in Engineering in Chemical Engineering with High Honors in
2000. He then moved to the California Institute of Technology
(Caltech) in Fall 2000 to begin his PhD in the lab of David Tirrell
as an NSF Graduate Research Fellow. During his PhD, Prof.
Link worked on azide-bearing unnatural amino acids with
applications in protein engineering and proteomics. Prof. Link
moved to the University of Texas at Austin for an NIH
postdoctoral fellowship with George Georgiou. In 2007, Prof.
Link moved back to Princeton as an assistant professor in the department of Chemical
Engineering, now named the department of Chemical and Biological Engineering. He
was promoted to associate professor in 2013. Prof. Link’s work at Princeton has been
recognized with awards including an NSF CAREER award, a DuPont Young Professor
Award, and a Sloan Fellowship in Chemistry.
IL-09
Macrocyclization of Site-Specific Protein-Poly(α-amino acid) Conjugates
Hua Lu*
College of Chemistry, Peking University, Beijing, 100871, P. R. China
Abstract
Cyclization and polymer conjugation are two commonly used approaches for enhancing
the pharmacological properties of protein drugs. However, cyclization of parental
proteins often only affords a modest improvement in biochemical or cell-based in
vitro assays. Moreover, very few studies have included a systematic pharmacological
evaluation of cyclized protein-based therapeutics in live animals. On the other hand,
polymer-conjugated proteins have longer circulation half-lives but usually show poor
tumor penetration and suboptimal pharmacodynamics due to increased steric hindrance.
We herein report the generation of a head-to-tail interferon–poly (α-amino acid)
macrocycle conjugate circ-P(EG3Glu)20-IFN by combining the aforementioned two
approaches. We then compared the antitumor pharmacological activity of this
macrocycle conjugate against its linear counterparts, N-P(EG3Glu)20-IFN, C-IFN-
P(EG3Glu)20, and C-IFN-PEG. Our results found circ-P(EG3Glu)20-IFN to show
considerably greater stability, binding affinity, and in vitro antiproliferative activity
toward OVCAR3 cells than the three linear conjugates. More importantly, circ-
P(EG3Glu)20-IFN exhibited longer circulation half-life, remarkably higher tumor
retention, and deeper tumor penetration in vivo. As a result, administration of the
macrocyclic conjugate could effectively inhibit tumor progression and extend survival
in mice bearing established xenograft human OVCAR3 or SKOV3 tumors without
causing severe paraneoplastic syndromes. Taken together, our study provided until now
the most relevant experimental evidence in strong support of the in vivo benefit of
macrocyclization of protein–polymer conjugates and for its application in next-
generation therapeutics.
References
(1) Hou, Y.; et al. and Lu, H. J. Am. Chem. Soc. 2018, 140, 1170-1178.
(2) Yuan, J.; Sun, Y.; Wang, J.; Lu, H. Biomacromolecules 2016, 17, 891-896.
(3) Hou, Y.; Yuan, J.; Zhou, Y.; Yu, J.; Lu, H. J. Am. Chem. Soc. 2016, 138, 10995-
11000.
Biography
Prof. Hua Lu is an assist professor in the College of Chemistry
and Molecular Engineering, Peking University. He obtained his
B.S. from Peking University in 2006 and PH.D. from the
University of Illinois at Urbana-Champaign in 2011. He worked
as a Damon Runyon Cancer Research Foundation postdoctoral
fellow at The Scripps Research Institute (TSRI, La Jolla, CA)
before he started his independent research in Peking University in
2014. His research focuses on the development of methodologies
for the controlled synthesis and medical applications of poly (α-
amino acid) s, sustainable polymers, and protein-polymer hybrids. He is a recipient of
ACS AkzoNobel Award for Outstanding Graduate Research in Polymer Chemistry
(2013), Excellent Young Investigator Grant of NSFC (2017), and Young Investigator
Award of the Chinese Chemical Society (2017).
IL-10
Organic boron compounds as novel fluorescent probes
Guoqiang Yang*
Institute of Chemistry, University of Chinese Academy of Sciences,
Chinese Academy of Sciences, Beijing, 100101, P. R. China
Organic boron compounds with electronic donor and/or acceptor group show sensitive
fluorescence with their environment. For the triaryl boron compounds, they give fluorescent
emission of typical intramolecular charge transfer (ICT) compounds due to the electron affinity
of the boron atom. These compounds have two emissive excited states and the energy difference
between them is small, so that a significant temperature effect is observed. Meanwhile, they
have relatively high fluorescence quantum yield due to the small size of the boron atom and its
crowed aryl surroundings. For their good stability and unique luminescent properties, triaryl
boron compounds are studied as novel luminescent probes for the detection of temperature, pH
value and special component in solutions and in bio-cells.
References
(1) Dehui Hu, Tao Zhang, Shayu Li, Tianjun Yu, Xiaohui Zhang, Rui Hu, Jiao Feng,
Shuangqing Wang, Tongling Liang, Jianming Chen, Lyubov N. Sobenina, Boris A. Trofimov,
Yi Li, Jinshi Ma, and Guoqiang Yang, Nature Comm. 2018, 9: 362，DOI: 10.1038/s41467-
017-02270-0.
(2) Jun Liu, Shilu Zhang, Chenghua Zhang, Jun Dong, Chengyi Shen, Jiang Zhu, Huajun Xu,
Mingkai Fu, Guoqiang Yang, Xiaoming Zhang. Chem. Commun., 2017, 53, 11476-11479.
(3) Jun Liu, Xudong Guo, Rui Hu, Jian Xu, Shuangqing Wang, Shayu Li,, Yi Li, and
Guoqiang Yang, Anal. Chem. 2015, 87, 3694−3698.
(4) Xuan Liu, Shayu Li, Jiao Feng, Yi Li and Guoqiang Yang, Chem. Commun., 2014, 50,
2778 – 2780.
(5) Xiaoyan Li, Xudong Guo, Lixia Cao, Zhiqing Xun, Shuangqing Wang, Shayu Li, Yi Li,
and Guoqiang Yang, Angew. Chem. Int. Ed., 2014, 53, 7809-7813.
Biography
Guoqiang Yang (born in 1963) received a BS degree (1985) in
chemistry from Peking University and a PhD degree (1991) from the
Institute of Photographic Chemistry, Chinese Academy of Sciences.
He was working in the Institute of Photographic Chemistry as an
Assistant (1991) and Associate Professor (1993), in the Kyoto
University of Japan (1992-1993, with Professor T. Shimizu) as a
Post-doc researcher of Japan Society for the Promotion of Science,
in the Ecole Nationale Superieure de Chimie de Mulhouse,
Universite de Haute-Alsace, France as a Visiting Professor (1995,
2001, 2003), and in the University of Illinois at Urbana-Champaign as a research associate
(1996-1999, with Professor H. G. Drickamer). From 1999, he has been working in the Institute
of Chemistry, Chinese Academy of Sciences as a full professor, and served as the Deputy
Director of the institute, Director of the Key Laboratory of Photochemistry. He is currently the
Vice President of the University of Chinese Academy of Sciences and Vice President of Chinese
Photochemistry Association. He is one of the Councilors of the Asian and Oceanian
Photochemistry Association, Assistant Editor for the Journal of Photochemistry and
Photobiology A: Chemistry and the member of the editorial committee of the Journal of
Photochemistry and Photobiology C: Review. His research interests include photo-functional
materials, electronic structure of the luminescent materials, novel fluorescent probes and effect
factors on the luminescent properties of the material. He has published 221 research papers and
has authorized 25 patents.
IL-11
Using Mobile NMR Spectroscopy to Study Chemical Problems in a Factory
Environment
Matthew P. Augustine
Department of Chemistry, University of California, Davis, California 95616, United
States
Abstract
Modern permanent magnet and radio frequency electronics technology now make
NMR spectroscopy amenable to process control in real factory environments. In
comparison to large, expensive, laboratory anchored superconducting magnet-based
spectrometers, it is the decreased size and durability of systems based on these
technological advances that now allows NMR to provide real time feedback during
industrial processes. The factory environment presents an interesting spectrometer
building challenge as standard 5 mm diameter, glass tubes containing pure compounds
or simple mixtures are rarely encountered. Samples are typically well defined,
reproducible complex mixtures presented in metal pipes at ambient or elevated pressure
or in large aseptic metal containers. Early work involving the NMR study of industry
standard sealed “Coke” cans is extended here to study tomato spoilage in 1,000 liter, 1
ton aseptic containers with single sided magnets of varied construction and coil
arrangement. The design and construction of the recently deployed NMR based
tomato spoilage detector will be described. Other early NMR work involving the
study of aqueous geochemistry at up to 3 GPa pressure is also extended here to study
both food and biomass in a high-pressure processing (0.5 GPa) situation for the first
time.
Biography
Matt Augustine is a Professor and Vice – Chair of
Chemistry at UC Davis. He received his BS in
Chemistry from Penn State University, focused on the
application of NMR to problems in Physical Chemistry
as a graduate student with Kurt Zilm at Yale University,
and refined his spectroscopic and theoretical skills as a
National Science Foundation post-doctoral scholar in
Alex Pines lab at UC Berkeley. Matt has spent his
entire career at UC Davis beginning as an Alfred P. Sloan
and David and Lucile Packard fellow, serving the
campus community as a member of the College of
Letters and Science Executive Council, a Faculty
Assistant to the Math and Physical Science Dean, and
more recently a Vice – Chair of the Chemistry Department, and receiving the UC Davis
Distinguished Teaching Award. His research is not conventional, has led to several
patents and a wine analysis company. His primary interest is to make the outdoor
environment his laboratory by developing field-deployable, rugged instruments to
perform spectroscopic measurements and solve chemical problems at the point of care
– a factory, a wine cellar, a mountain, etc.
IL-12
Genetically Encoded Click Chemistry: New Tools for Protein-based
Materials
Wen-Bin Zhang*
College of Chemistry, Peking University, Beijing, 100871, P. R. China
Abstract
Genetically encoded chemistry provides versatile control over the process of
chemical reactions and the resulting materials. The spontaneous formation of an
isopeptide bond between a peptide tag and its protein partner is a genetically encoded,
cell-compatible, highly specific and efficient chemistry for protein/peptide conjugation,
as demonstrated in the chemically reactive pair of SpyTag/SpyCatcher.1 In this talk, I
will give a brief overview of our work in the development of genetically encoded
protein chemistry tools (especially those possessing features of click chemistry) and the
use of such tools to create bioactive materials. Through protein engineering, we have
successfully developed a chemical toolbox of genetically encoded chemical reactions.
The possibility to encode chemical information into protein sequences has allowed the
direct cellular synthesis of cyclic proteins, tadpole proteins, star proteins, and other
branched topologies.2 The reaction between proteins bearing multiple reactive groups
also lead to all-protein-based bioactive hydrogels, whose macroscopic properties are
fully genetically encodable.3 By combining this chemistry with protein folding, protein
catenanes and other complex protein topologies can be prepared.4,5 In general,
catenation was found to increase proteins’ stability toward proteolytic digestion and
thermal denaturation.6 It has thus opened new ways to engineer protein’s properties,
both in vivo and in vitro, which has general implications for protein-based materials.
References
(1) B. Zakeri, J.O. Fierer, E. Celik, E. C. Chittock, U. Schwarz-Linek, V. T. Moy, M.
Howarth, Proc. Natl. Acad. Sci. USA 2012, 109, E690.
(2) W. B. Zhang, F. Sun, D. A. Tirrell, F. H. Arnold, J. Am. Chem. Soc. 2013, 135, 13988.
(3) F. Sun, W. B. Zhang, A. Mahdavi, F. H. Arnold, D. A. Tirrell, Proc. Natl. Acad. Sci.
USA 2014, 111, 11269.
(4) X. W. Wang, W. B. Zhang, W.-B. Angew. Chem. Int. Ed. 2016, 55, 3442.
(5) Liu, D.; Wu, W.-H.; Liu, Y.-J.; Wu, X.-L.; Cao, Y.; Song, B.; Li, X.; Zhang, W.-B.
ACS Cent. Sci. 2017, 3, 473.
(6) X. W. Wang, W. B. Zhang, W.-B. Angew. Chem. Int. Ed. 2017, 56, 15014.
Biography
Wen-Bin Zhang is currently an Assistant Professor at the
Department of Polymer Science and Engineering, College of
Chemistry and Molecular Engineering of Peking University.
He received his B.S. in Organic Chemistry from Peking
University in 2004 and his Ph.D. in Polymer Science from
the University of Akron in 2010. He continued at the
University of Akron for his postdoctoral research under the
supervision of Prof. Stephen Cheng for one year, before he
moved to Caltech for a second postdoctoral training with
Prof. David Tirrell in Protein Engineering and Biomaterials. His current research
interests include the rational development of materials that bridges synthetic systems
and biological systems for energy and health-related applications. In particular, he is
interested in developing genetically encoded protein click chemistry and the use of such
tools for protein topology engineering and protein-based bioactive materials.
IL-13
Bioorthogonal Cleavage Reactions in Living Systems
Peng Chen*
College of Chemistry, Peking University, Beijing, 100871, P. R. China
Abstract
Employing small molecules or chemical reagents to modulate the function of an intracellular
protein of interest, particularly in a gain-of-function fashion, remains a challenge. In this talk,
I will introduce a “chemical decaging” strategy that relies on our developed Bioorthogonal
Elimination Reactions to control protein activation in living cells. These reactions exhibited
high efficiency and low toxicity for chemical decaging of the masked-lysine residue on
intracellular proteins, which is complementary to the previously used photo-decaging reactions.
In certain applications, particularly within live animals, small-molecule mediated chemical
decaging is highly desired and advantageous. We are currently employing this method to block
specific kinase’s activity in living cells, which allowed the subsequent gain-of-function study
of each kinase within the intracellular signaling transduction network. Together, our strategy
expanded the view of Bioorthogonal chemistry beyond ligation reactions, which may be
generally applicable for chemically rescuing of a given protein, thus manipulating its activity
within a native cellular context.
References
1. Li J, Chen P. “Development and application of bond-cleavage reactions in bioorthogonal
chemistry” Nat. Chem. Biol. 2016, 12, 129-37.
2. Zhang G, Li J, Xie R, Fan X, Liu Y, Zheng S, Ge Y, Chen P. “Bioorthogonal chemical
activation of kinases in living systems”, ACS Cent. Sci. 2016, 2, 325-31.
3. Wang J, Zheng S, Liu Y, Zhang Z, Lin Z, Li J, Zhang G, Wang X, Li J, Chen P. “Palladium-
triggered chemical rescue of intracellular proteins via genetically encoded allene-caged
tyrosine”, J. Am. Chem. Soc. 2016, 138, 15118-21.
4. Li J, Jia S, Chen P “Diels-Alder reaction-triggered bioorthogonal protein activation in
living cells”, Nat. Chem. Biol., 2014, 10, 1003-5.
5. Li J, Yu J, Zhao J , Wang J, Zheng S, Lin S, Chen L, Yang M, Jia S, Zhang X, Chen P.
“Palladium-triggered deprotection chemistry for protein activation in living cells”, Nat.
Chem. 2014, 6, 352-61.
Biography
Professor Peng Chen is now the Chairman of Department of Chemical
Biology at Peking University. He obtained BS degree in Chemistry at
Peking University in 2002 and Ph.D in Chemistry at The University of
Chicago in 2007. After a postdoctoral training at The Scripps Research
Institute, he started his independent career as an Investigator at Peking
University in July 2009 and has been promoted to Full Professor with
tenure in 2014. His research focuses on developing and applying novel
chemistry tools to investigate protein-based interactions and activities
in living cells. His lab is best known for the creation of versatile genetically encoded
photocrosslinkers for studying protein-protein interactions, as well as the development of
bioorthogonal cleavage reactions for protein activation in living systems. He received many
awards including NSFC Distinguished Young Scholar Award (2012), RSC Chemical Society
Review Emerging Investigator lectureship (2014), The Chemical Society of Japan
Distinguished Lectureship Award (2015), Young Scientist Award from Ministry of Education
in China (2016), Tan Kah Kee Young Scientist Award (2016), and Society of Biological
Inorganic Chemistry Early Career Award (SBIC award, 2017).
IL-14
The Secret Life of the Genome: Repair of DNA base modifications
Sheila David
Department of Chemistry, University of California, Davis, California 95616, United States
Abstract
The DNA bases hold the informational content of DNA. Modified DNA bases are
considered “DNA damage” and have the potential to alter the coding properties and
cause deleterious DNA mutations. There is also a growing appreciation that DNA base
modifications may influence a broad range of cellular processes beyond mediating
permanent DNA mutations. DNA glycosylases play a key role in removing damaged
DNA bases as an initiating step in base excision repair (BER). We have focused
extensively on the repair of oxidized guanines, and the BER glycosylases MUTYH and
NEIL1. MUTYH is the human homolog of MutY and is a [4Fe-4S] cluster glycosylase
that targets removal of an undamaged adenine from 8-oxoguanine (OG):A mismatches.
In contrast, NEIL1 removes a broad range of oxidized guanine lesions, as well as
oxidized pyrimidines, and also is capable of removing lesions in a wide variety of
contexts including ssDNA and G-quadruplexes. Using a multi-pronged approach
including enzyme kinetics, structural studies and cellular assays, we have revealed key
features involved in the recognition and base excision activity of these two distinct
glycosylases. For example, we have recently revealed that the 2-amino group of OG
is a key feature for the initial detection of OG:A over T:A base pairs. My laboratory
also played an important role in the discovery of MUTYH-associated polyposis (MAP),
an inherited form of colorectal cancer, by revealing that the two most common MAP
variants have a hampered ability to recognize OG. We have continued to reveal
interesting features of MAP variants, and the location and dysfunction of disease-
associated variants has provided a window for revealing new features of MUTYH. We
also have shown that the hydantoin lesions Gh and Sp are the best-documented
substrates for NEIL1. In addition, we uncovered that there are two forms of the NEIL1
glycosylase resulting from mRNA editing (recoding) that have distinct differences in
enzymatic processing of DNA base lesions. More recently, we have revealed features
of the repair that are unique to a given NEIL1 substrate and the consequences of NEIL1
recoding. Comparing and contrasting the two glycosylases illustrates the “fine-tuning”
provided by DNA repair glycosylases to detect, mediate and respond to DNA base
modifications.
Biography
Sheila David received her Ph.D. from the University of
Minnesota in 1989. She was an NIH Postdoctoral Fellow
from 1990-1992 at the California Institute of Technology.
She became an assistant professor at the University of
California, Santa Cruz in Fall of 1992, and then
subsequently moved to the University of Utah in 1996,
where she rose through the ranks to Full Professor in 2002.
In 2006, she joined the Chemistry Department, University
of California, Davis. She has received several prestigious
awards, including a UCD ADVANCE Scholar Award for
excellence in research and mentoring, ACS Fellow in 2011,
AAAS Fellow in 2010, A. P. Sloan Research Fellow Award
for 1998-2002, Arnold and Mable Beckman Young Investigator Award (1992-1994).
She serves on editorial advisory boards for DNA repair, (2005-Present) and Cell
Chemical Biology. (2015-present). Her research focuses on using chemical biology
approaches to study DNA repair.
IL-15
Reversible RNA Adenosine Methylation in Plant Biological
Regulation
Guifang Jia*
Synthetic and Functional Biomolecules Center, Beijing National Laboratory for
Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular
Engineering of Ministry of Education, College of Chemistry and Molecular
Engineering, Peking University, Beijing 100871, China
Abstract
m6A is the most prevalent internal modification in eukaryotic mRNA and preferentially occurs
at the consensus sequence [G/A/U][G>A]m6AC[U>A>C] with a non-stoichiometric ratio.
Although it was first found in 1970s, relative to DNA modifications, the research on m6A
lagged behind due to the lack of detection techniques for RNA modifications. Until 2011, the
discovery of FTO as an m6A-demethylase demonstrates m6A is a reversible and dynamic RNA
modification and reignites investigation of m6A. In 2012, two research group developed m6A
antibody immunoprecipitation-based sequencing method (termed m6A-seq or MeRIP) and
reported the whole-transcriptomic m6A maps. m6A is installed by a methyltransferase complex
(writer) with key subunits identified as METTL3 (Methyltransferase-like 3), METTL14 and
WTAP (Wilms tumour 1-associating protein). So far only two m6A demethylases (eraser), FTO
and ALKBH5 (AlkB homolog 5), have been characterized. m6A is recognized by reader
proteins (such as YTH family proteins) to regulate RNA fate, including mRNA stability,
splicing, nuclear export, translation, primary microRNA processing, and RNA-protein
interactions. These processes affect circadian rhythms, stem cell pluripotency, cancer stem cell
proliferation, RNA virus infection, sex determination in Drosophila, and so on, revealing that
m6A plays critical roles in various biological processes. However, the study of m6A methylation
in Arabidopsis thaliana has been limited to the m6A methyltransferase. Here we will discuss
our discovery and characterization of reversible m6A methylation mediated by demethylase and
read by m6A-binding protein in A. thaliana, and noticeable regulatory roles of these RNA
demethylase a reader in plant development especially floral transition. Our findings reveal
potential broad functions of reversible mRNA methylation in plants.
Keywords: Epitranscriptome; RNA modification; N6-methyladenosine (m6A); m6A
demethylase; m6A-binding protein (m6A reader)
References:
1. Jia, G.#, Fu, Y.#, Zhao, X.#, Dai, Q., Zheng, G., Yang, Y., Yi, C., Lindahl, T., Pan, T.,
Yang, Y. G., He, C.* Nat. Chem. Biol., 7, 885-7, 2011.
2. Jia, G., Fu, Y., He, C.* Trends Genet., 29, 108-15, 2013.
3. Luo, G.Z., MacQueen, A., Zheng, G., Duan, H., Dore, L.C., Lu, Z., Liu, J., Chen, K., Jia,
G.*, Bergelson, J.*, He, C.* Nat. Commun., 5, 5630, 2014.
4. Liu, J.Z., Yue, Y., Han, D., Wang, X., Fu, Y., Zhang, L., Jia, G., Yu, M., Lu, Z., Deng, X.,
Dai, Q., Chen, W., He, C. *Nat. Chem. Biol., 10, 93-5, 2014.
5. Wang, X., Lu, Z., Gomez, A., Hon, G. C., Yue, Y., Han, D., Fu, Y., Parisien, M., Dai, Q.,
Jia, G., Ren, B., Pan, T., He, C.* Nature, 505, 117-20, 2014.
6. Duan, H-C., Wei, L-H., Zhang, C., Wang, Y., Chen, L., Lu, Z., Chen, P., He, C.*, Jia, G.*
Plant Cell, 29, 2995-3011, 2017.
Biography
Guifang Jia is currently an Associated Professor at Department of
Chemical Biology, College of Chemistry and Molecular
Engineering of Peking University since 2012. She received her B.S.
in Chemistry from China Agricultural University in 2002 and her
Ph.D. in Pesticide Residue Analysis from China Agricultural
University in 2008. She became a visiting student at the University
of Chicago to study chemical biology under the supervision of Prof. Chuan He in 2007,
and continued her postdoctoral research in the laboratory of Prof. Chuan He at the
University of Chicago. Her current research interests including the biological functions
of epitranscriptomics/RNA modifications in human health and plant developments, and
the devlopment of small molecule tuning of epitranscriptomic regulation.
IL-16
Sustainable Production of Biofuels and Bioproducts from Microalgae
Annaliese Franz
Department of Chemistry, University of California, Davis, 95618, USA
Abstract
Microalgae is a promising feedstock for sustainable production of biofuels and biochemicals;
However, production of fuel feedstocks from microalgae remains prohibitively expensive despite
significant advances in the field. The high costs of nutrients needed for cultivation is a challenge for
large-scale production. To address these challenges, we have investigated the use of nutrient-rich
wastewaters as well as the co-production of value added chemicals from microalgae-based biofuel
production systems. We have investigated the production of one class of valuable co-product;
bioactive lipids with. that can regulate diverse biological functions and are important to human
health. Bioactive lipids are expensive to produce using synthetic means or enzymatically by
fermentation so this provides a valuable opportunity to access these molecules while also using a
co-product strategy to reduce the cost of fuel feedstocks. We describe the development of analytical
methods to measure various lipids in microalgae, including bioactive lipids, and make the first report
of treatment conditions that induce the production of bioactive lipids. Several industrially relevant
microalgae strains have been investigated in this study to compare the production of bioactive lipids
under treatment conditions. Treatment of one strain of microalgae with a chemical trigger under
environmental nutrient stress increased the accumulation of a class of bioactive lipids by up to 400%.
The synergistic approach of utilizing a chemical trigger to enrich the content of bioactive lipids in
microalgae biomass uses methods congruent with current industrial cultivation practices. This
system provides a foundation for studying the mechanisms of formation for bioactive lipids in
microalgae and the development of a biological production route for specific classes of bioactive
lipids.
Biography
Annaliese Franz is an associate Professor in the Department of
Chemistry, and Faculty Director of the Undergraduate Research
Center at UC Davis. She received her B.S. degree in Chemistry from
Trinity University in San Antonio, TX, and her Ph.D. in Organic
Chemistry at UC Irvine in 2002 (Advisor: Keith Woerpel). Then she
moved to Harvard University where she was awarded an NIH
Postdoctoral Fellowship (2002-2005) working under the guidance of
Prof. Stuart Schreiber and then continued her research at the Broad
Institute of Harvard and MIT from 2005-2007. In 2007, Annaliese started as an Assistant Professor
in the Chemistry Department at UC Davis aestablished a research program focused on organic
synthesis, catalysis, bioanalytical chemistry and production of biofuels and bioactive lipids from
microalgae. She has received several awards, including an NSF CAREER award, the American
Chemical Society WCC Rising Star Award, the Outstanding Mentor Award from the Consortium
for Women & Research at UC Davis and an ADVANCE Scholar at UC Davis.
IL-17
Non-equilibrium protocell models with “living” features
Dehai Liang*
Key Laboratory of Polymer Chemistry and Physics of the Ministry of Education, College of
Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
Numerous strategies are now available to generate rudimentary forms of synthetic cell-like
entities; however, minimal progress has been made in the sustained excitation of artificial
protocells under non-equilibrium conditions to achieve dynamic features with life-like
properties. As a consequence, even the most highly integrated protocellular systems are
functionally compromised compared with basic life processes, which occur under a continuous
flux of energy and matter exchange. Thus, a major challenge in synthetic protocell research
involves the development of methodologies that enable the sustained activation of chemical
micro-ensembles such that they persist and function under non-equilibrium conditions.
Since electric fields exist both extracellularly and intracellularly, and play a role in
dynamical processes such as tissue morphogenesis and regeneration, we explore the
possibilities of creating non-equilibrium protocells in the presence of electric field. The
coacervate micro-droplets comprising polylysine and short single strands of DNA are formed
within a microfluidic channel. When electric field is applied, the protocells exhibit two dynamic
features: repetitive cycles of vacuolarization and fluid circulation. By taking advantage of the
interplay between vacuolization and circulation, we achieve dynamical fluctuations in size and
shape, chaotic growth and fusion, spontaneous ejection and sequestration of matter, directional
capture of solute molecules, and dynamic localization of an enzyme cascade reaction at specific
droplet locations. Our work represents a novel strategy to couple complex hydrodynamics,
matter exchange, and chemical reactivity within the interior of molecularly crowded coacervate
micro-droplets, and as such provides a step towards the non-equilibrium functionalization of
synthetic protocells capable of biomimetic operations.
References
(1) Jaffe, L. F. Proc. Natl. Acad. Sci. USA 1966, 56, 1102.
(2) Tyner, K. M., Kopelman, R., Philbert, M. A. Biophys. J. 2007, 93, 1163.
(3) Ojingwa, J. C.,Isseroff, R. R., J. Invest. Dermatol. 2003, 121, 1.
(4)Yin, Y. D., Niu, L., Zhu, X. C., Zhao, M. P., Zhang, Z. X., Mann, S., Liang, D. H. Nature
Communications 2016, 7, 10658
Biography
Dehai Liang (born in 1971) received his BS degree (1994) in
chemistry from Nankai University and PhD degree (2001) from the
State University of New York (SUNY) at Stony Brook in USA.
From 2005, he has been working in the college of chemistry,
Peking Unversity as an assciate professor, and promoted as
Professor in 2012. His research interests include electric field
excitation and non-equilibrium dynamics in protocells, anisotropic
assembly regulated by macromolecular crowding and confinement,
peptide mediated endocytosis of biomembrane, enzyme reaction in
polyelectrolyte complex, and lung-targeting siRNA delivery vehicles. He has published more
than 120 research papers and has authorized 5 patents.
IL-18
Microwave spectroscopy for chemical kinetics and laboratory
astrophysics
Kyle N. Crabtree
Department of Chemistry, University of California, Davis, Davis, CA 95616 USA
Abstract
Over 200 molecules have been detected to date in the interstellar medium and in
circumstellar shells. Yet despite considerable advances in the capabilities of
astronomical telescopes, a detailed understanding of the formation and destruction of
molecules in space remains elusive. Accurate modeling of astrochemical processes
requires laboratory measurements of molecular spectra and of chemical reactions under
conditions relevant for astrophysical environments. Developments in broadband
microwave technology over the past decade have enabled rotational spectroscopy to
become a highly versatile technique for molecular identification and quantitation in the
gas phase. We have combined a Ka-band chirped-pulse Fourier transform microwave
spectrometer with the uniform supersonic flow generated by a pulsed Laval nozzle to
investigate the kinetics of astrophysically important chemical reactions between
radicals (formed by pulsed laser photolysis of a suitable precursor) and neutral polar
molecules. The current status and prospects of the technique are discussed.
Biography
Kyle Crabtree has been an Assistant Professor at the University of
California, Davis, since 2014. He earned his B.S. in Chemistry
from Ball State University in 2006 and his Ph.D. in Chemistry
from the University of Illinois in 2012. From 2012-2014 he was a
CfA Postdoctoral Fellow at the Harvard-Smithsonian Center for
Astrophysics, where he worked in the laboratory of Dr. Michael C.
McCarthy. His current research involves application of microwave
spectroscopy for studying chemical kinetics of astrochemically
important reactions, developing automated analysis tools for
microwave spectroscopy, and measuring VUV photodissociation of transient diatomic
species for UV photochemical models of the interstellar medium.
IL-19
Energy Transfer in the X-ray Regime: X-ray Induced Energy Transfer (XIET)
Ting Guo
Department of Chemistry, University of California, Davis, CA 95616
Abstract
In this talk, the results of a systematic theoretical study of a new phenomenon of X-
ray Induced Energy Transfer (XIET) within the purview of X-ray nanochemistry are
presented. X-ray nanochemistry explores utilization of nanostructures for the purpose
of absorbing X-rays to drive actions such as catalytic DNA strand breaks or
polymerization enabled at locations buried deep in opaque objects. XIET occurs
between a strongly X-ray absorbing nanomaterial such as one or more gold
nanoparticles and a weakly X-ray absorbing nanomaterial such as a hollow silica
nanoparticle filled with water; part of the energy absorbed by the former can be
transferred to the latter when the two are positioned sufficiently close together. The
strongly X-ray absorbing nanomaterial which releases energy after X-ray absorption
are called donors and the weakly X-ray absorbing nanomaterial receiving energy from
the donors are called acceptors. XIET related concepts were studied in the past, but in
a more general sense of energy deposition in theoretically defined volumes surrounding
donors, rather than in nanoscale acceptors as explored in this work. The results of
theoretical study of XIET as a function of dimension, composition, configuration and
orientation of donors and acceptors, number of donors, and X-ray energy are given.
Results of relative and percentage XIET efficiencies are discussed. The results
presented in this talk provide a theoretical framework to guide future experimental
XIET studies.
Biography
Professor Ting Guo obtained his Ph.D. in chemistry at Rice
University in 1995. He pursued a postdoctoral training in the
Department of Chemistry at University of California at San Diego.
He joined the faculty of the Department of Chemistry at
University of California, Davis in 1999. Currently he is professor
of Chemistry and Chair of the Department of Chemistry. His
group works on understanding energy flow between molecules
and nanostructures. The main focus of his research is developing nanochemical systems
to harvest X-ray photons and convert the absorbed energy to chemical, optical, electric
energy. Other projects include using fluorescence quenching as sensors, developing
methods to remove water from surface, and delivering genetic content into plants.
IL-20
Single-Molecule Electrical Detection
Xuefeng Guo*
College of Chemistry, Peking University, Beijing 100871, P. R. China
Abstract
A universal lithographic methodology for creating single-molecule devices based on
carbon nanomaterials as point contacts has been developed. In this talk, I will detail our
rational bioassay techniques by using molecular bridges with functional side groups
capable of subsequent biocompatible assembly. We have tested this approach in
chemical/biological systems, including DNA hybridization, aptamer-protein interaction,
host-guest interaction, hydrogen-bond dynamics and basic chemical reactions. Because
it is constructed from a single molecule, each device can monitor individual binding
events in real time. This methodology demonstrates a connection between electrical
conduction and chemistry/biology that offers a glimpse into the future of integrated
multifunctional sensors and devices.
Figure 1. Schematic of single-molecule detection using molecular electronic devices.
References：
[1] C. Jia, X. Guo, et al., Science 352, 1443 (2016).
[2] D. Xiang, X, Wang, C. Jia, T. Lee, X. Guo, Chem. Rev. 116, 4318 (2016).
[3] C. Jia, B. Ma, N. Xin, X. Guo, Acc. Chem. Res. 48, 2565 (2015).
[4] X. Guo, C. Nuckolls, et al., Nat. Nanotech. 3, 163 (2008).
[5] X. Guo, Adv. Mater. 25, 3397 (2013).
[6] A. Feldmen, X. Guo, C. Nuckolls, et al., Acc. Chem. Res. 41, 1731 (2008).
[7] X. Guo, P. Kim, C. Nuckolls, et al., Science 311, 356 (2006).
[8] Y. Cao, X. Guo, et al., Angew. Chem. Int. Ed. 51, 12228 (2012).
[9] J. Wang, X. Guo, et al., Angew. Chem. Int. Ed. 53, 5038 (2014).
[10] G. He, J. Li, C. Qi, X. Guo, Angew. Chem. Int. Ed. 55, 9036 (2016).
Biography
Xuefeng Guo received his Ph.D. degree in Organic Chemistry in
2004 from the Institute of Chemistry, Chinese Academy of
Science, Beijing. In 2006, he was awarded the National Top 100
Excellent Ph. D. Thesis Award in China. From 2004 to 2007, he
was a joint postdoctoral scientist at the Columbia University
Nanocenter. He joined the faculty as a professor under “Peking
100-Talent” Program at College of Chemistry and Molecular
Engineering, Peking University in January 2008. In 2012, he won the National Science
Fund for Distinguished Young Scholars in China. His research interests are focused on
single-molecule devices and device physics, flexible/organic electronics, single-
molecule detection and dynamics, etc.
IL-21
Ultrafast Direct Electron Transfer at Organic Semiconductor and
Metal Interfaces
Wei Xiong
University of California- San Diego, 92093
Abstract
In this talk, I will give an overview of a few state-of-the-art ultrafast nonlinear
spectroscopy works in my group, spanning from model electrochemical catalysis,
optoelectronic devices to novel molecular photonic materials. I will particularly focus
on a recent study on ultrafast direct interfacial charge transfer. The ability to control
direct electron transfer can facilitate the development of new molecular electronics,
light-harvesting materials and photocatalysis. However, it has been rarely reported and
the molecular conformation-electron dynamics relationships remain unclear. Here, we
describe direct electron-transfer at buried interfaces between an organic polymer
semiconductor film and a gold substrate, by observing the first dynamical electric-field-
induced vibrational sum frequency generation (VSFG). In transient electric-field-
induced VSFG measurements on this system, we observe dynamical responses (<150
fs) that depend on photon-energy and polarization, evidencing that electrons are directly
transferred from Fermi level of gold to LUMO of organic semiconductor. Transient
spectra further reveal that, although the interfaces are prepared without deliberate
alignment control, a sub-ensemble of surface molecules can adopt conformations for
direct electron transfer. DFT calculations support the experimental results and ascribe
the observed electron transfer to a flat-lying polymer configuration in which electronic
orbitals are found to be delocalized across the interface. The present observation of
direct electron transfer at complex interfaces as well as the insights gained into the
relationship between molecular conformations and electron dynamics will have
implications for implementing novel direct electron transfer in energy materials.
References：
1. B. Xiang, Y. Li, C.H. Pham, F. Paesani, W. Xiong, “Ultrafast Direct Electron Transfer at
Organic Semiconductor and Metal Interfaces”, Science Advances 2017, 3: e1701508.
Biography
Wei Xiong is an assistant professor of Chemistry and Biochemistry
at University of California- San Diego. He received his B.S.
degree in Chemistry from Peking University in 2006, then his Ph.D.
degrees in Chemistry from University of Wisconsin-Madison in
2011, under the supervision of Prof. Martin t. Zanni. Since 2011,
he was a postdoctoral researcher in the Kapteyn-Murnane group, at
JILA, University of Colorado-Boulder. Wei joined the Department
of Chemistry and Biochemistry at UCSD at 2014. Wei is a
recipient of prestigious awards including 2015 DARPA YFA, 2016 AFOSR YIP, and
2017 DARPA Director’s Fellowship. His research focuses on developing novel ultrafast,
interfacial sensitive, optical spectroscopies and microscopies, in order to both space-
and time-resolve charge and molecular dynamics in complex materials and biological
interfaces. Lab website: http://ultrafast.ucsd.edu.
IL-22
Probing interfacial water at submolecular level by scanning probe microscopy
Ying Jiang*
International Center for Quantum Materials, Peking University, Beijing, 100871, P.
R. China
Abstract
Interfacial water is ubiquitous in nature and plays an essential role in a broad spectrum
of physics, chemistry, biology, energy and material sciences. One of the most
fundamental issues is the characterization of H-bonding configuration formed on
surfaces and H-atom transfer through hydrogen bonds. Ideally, attacking this problem
requires the access to the internal degrees of freedom of water molecules, i.e. the
directionality of OH bonds. However, it remains a great challenge due to the small size
of hydrgen. In this talk, I will present our recent progress on the development of new-
generation scanning probe microscopy/spectroscopy (SPM/S) with ultrahigh sensitivity
and resolution, and its application to surface water. I will foucus on how to achieve
submolecular-resolution imaging [1,2] and single-bond vibrational spectroscopy [3] of
single water molecules via controlling tip-water coupling. Those technical advances
provide us unprecedented opportunity to identify the topology of H-bonding
configuration [4], track the proton dynamics [5], and assess quantitatively the nuclear
quantum effects (NQEs) of H bond [3,5]. The submoleuclar-level studies of ion
hydrates and two-dimensional ice structures will be also briefly introduced in the end.
References
1. J. Guo, X. Z. Meng, J. Chen, J. B. Peng, J. M. Sheng, X. Z. Li, L. M. Xu, J. R.
Shi, E. G. Wang*, Y. Jiang*, Nature Materials 13, 184 (2014).
2. J. Peng, J. Guo, P. Hapala, D. Cao, R. Ma, B. Cheng, L. Xu, M. Ondráček, P.
Jelínek*, E. G. Wang*, and Y. Jiang*, Nature Communications 9, 122 (2018).
3. J. Guo, J.-T. Lü, Y. Feng, J. Chen, J. Peng, Z. Lin, X. Meng, Z. Wang, X.-Z. Li*,
E.-G. Wang* and Y. Jiang*, Science 352, 321 (2016).
4. J. Chen, J. Guo, X. Z. Meng, J. B. Peng, J. M. Sheng, L. M. Xu, Y. Jiang*, X. Z.
Li*, E. G. Wang, Nature Communications 5, 4056 (2014).
5. X. Meng, J. Guo, J. Peng, J. Chen, Z. Wang, J. R. Shi, X. Z. Li, E. G. Wang*, Y.
Jiang*, Nature Physics, 11, 235 (2015).
Biography
Ying Jiang received his Bachelor’s degree from Beijing Normal
University in 2003 and his PhD from Institute of Physics,
Chinese Academy of Sciences (CAS) in 2008. He has been a
visiting scientist in Forschungszentrum Jülich GmbH in
Germany (2006-2007). After working as a Postdoctoral
Associate in University of California, Irvine (2008-2010), he
joined International Center for Quantum Materials, Peking University as a tenure-track
assistant professor. He was promoted to associate professor with tenure in 2016 and full
professor in 2018. He has published over 30 peer-reviewed papers, including 2 in
Science and 6 in Nature Journals. He has delivered over 40 invited talks (including 5
plenary talks) in a number of international conferences. He was awarded Outstanding
Young Scientist (2012), Cheung Kong Young Scholar (2016), Emerging Leader (IOP,
2016), Distinguished Young Scholars of NSFC (2017). His research works were
selected as Top-ten Progresses of Science and Technology of China (2016) and Top-ten
Progresses of Basic Research of China (2017). He is an expert in advanced scanning
probe microscopy and spectroscopy. His current interests are focused on the atomic-
scale properties and ultrafast dynamics in single molecules and low-dimensional
materials.
IL-23
New Advances in 3D Nanoprinting
Gang-yu Liu
Department of Chemistry, University of California, Davis, California 95616, United States
3D printing has been a very active area of research and development (R&D) in the context of
additive manufacture, due to its capability to produce 3D objects by design. Current 3D nanoprinting
technology pushes the spatial limit to micrometer scale. Further miniaturization represents a major
challenge in current R&D effort in 3D printing. This work reports new advances in miniaturizing
3D printing to nanometer scale using scanning probe microscopy in conjunction with local material
delivery such as nanofluidics.[1] Using various materials, the concept of layer-by-layer nanoprinting
by design have been demonstrated.[1-2] Nanometer precision is achieved in all three dimensions,
as well as in inter-layer registry, as shown in Figure 1. The approach and results provide a new and
general platform for conducting scientific research in designed 3D nano-environments, as well as
enabling production of new nanomaterials and scaffolds for photonics, devices, biomedicine and
tissue engineering.[3-4]
Figure 1. An atomic force microscopy
based 3D nanoprinting using a
nanofluidic probe (A). The
dendrimers self-assembled into
nanoline arrays with carters (B), while
star-polymers form arrays of bamboos. The former represents weak inter-molecular interaction,
while the later represents strong interaction.
References:
1. Zhao, J.; Swartz, L.; Lin, W. F.; Schlenoff, P.; Frommer, J.; Schlenoff, J.; Liu,
G. Y. 3D Nanoprinting via Scanning Probe Lithography in Conjunction with
Layer-by-Layer Deposition, ACS Nano 2016, 10, 5656−5662.
2. Ventrici de Souza, J.F., Y. Liu, S. Wang, P. Dorig, T. Kuhl, J. Frommer and G.-y.
Liu. Three-Dimensional Nanoprinting via Direct Delivery. J. Phys. Chem. B.,
2018, In press.
3. Li, J. R.; Ross, R. S.; Liu, Y.; Liu, Y. X.; Wang, K. H.; Chen, H.-Y.; Liu, F. T.;
Laurence, T. A.; and Liu, G. Y. Engineered Nanostructures of Haptens Lead to
Unexpected Formation of Membrane Nanotubes Connecting Rat Basophilic
Leukemia Cells, ACS Nano, 2015, 9, 6738–6746.
4. Deng, Z., I.C. Weng, J.R. Li, H.Y. Chen, T.T. Liu and G.Y. Liu. Engineered
Nanostructures of Antigen Provide an Effective Means for Regulating Mast Cell
Activation. ACS Nano, 2011, 5(11), 8672–8683.
Biography:
Gang-yu Liu received her Ph.D. from Princeton
University in 1992. Following a two-year
postdoctoral research at University of California,
Berkeley, under a Miller Research Fellowship, she
became an assistant professor at Wayne State
University, where she received a tenure in 1999. In
2001, she joined the Chemistry Department,
University of California, Davis. She has received
several prestigious awards, including an ACS Fellow
in 2010, AAAS Fellow in 2007, Sloan Faculty
Recognition Award in 2007, NSF-CAREER Award
(1997), Arnold and Mable Beckman Young
Investigator Award (1996-1998), and the Camille and Henry Dreyfus New Faculty Award (1994-
1999). She has been a senior editor for the J. Phys. Chem. since 2005. She serves on editorial
advisory boards for ACS Nano, (2007-Present) and ACS Applied Nanomaterials. (2017-present).
Her research focuses on advanced technology development for 3D nanoprinting, bioimaging, and
applications in biomedical research.
IL-24
Hybrid Voltage Indicators for Imaging Neural Activity
Peng Zou*
College of Chemistry, Peking University, Beijing, 100871, P. R. China
Abstract
Membrane voltage is an important biophysical signal. Optical mapping of membrane voltage
enables investigation of electrical signaling at high spatial resolutions and with high throughput.
In this talk, I will describe a recently developed fluorescent voltage indicator scaffold (Flare1)
that builds upon the site-specific modification of microbial rhodopsin with organic fluorophores.
Flare1 achieved 36% ΔF/F per 100 mV voltage change with sub-millisecond response kinetics,
thus representing one of the most sensitive and fastest orange-colored voltage indicators. This
technique has enabled observation of long-range electrical coupling among mammalian cells
that was mediated via gap-junctions. Combining the superior brightness and photostability of
small molecules with genetic targeting of microbial rhodopsin proteins, this design strategy can
be extended for developing novel fluorescent indicators.
References
(1) Y. Xu, P. Zou*, A. E. Cohen*. Curr. Opin. Chem. Biol. 2017, 39, 1-10.
(2) P. Zou#, Y. Zhao#, A. D. Douglass, D. R. Hochbaum, D. Brinks, C. A. Werley, D. J. Harrison,
R. E. Campbell, A. E. Cohen. Nat. Commun., 2014, 5, 4625.
Biography
Peng Zou is currently an Assistant Professor at the Department of
Chemical Biology, College of Chemistry and Molecular
Engineering of Peking University (PKU). He received his
Bachelor’s degree in Chemistry and in Physics from PKU in 2007,
and his PhD in Biological Chemistry (with Alice Ting) from MIT
in 2012. He was a postdoc fellow at Harvard University (with
Adam Cohen) from 2013 to 2015, before returning to PKU to start
his faculty appointment. He is affiliated with the Synthetic and
Functional Biomolecules Center, Peking-Tsinghua Center for Life Sciences and the PKU-
IDG/McGovern Institute for Brain Research as Principle Investigators. His research focuses on
developing chemistry-enabled tools for studying the structure, dynamics, and function of
neurons.
IL-25
Chemistry of atmospheric particles
Peter B. Kelly
Department of Chemistry, UC Davis, Davis, CA 95616
Abstract
Aerosols collected in Oslo with an aerodynamic size below 2.5 µm were
gravimetrically weighed to acquire mass concentrations and analyzed by Accelerated
Mass Spectrometry to separate the particulate bound carbon as biogenic or fossil
derived. Results were compared to levoglucosan measurements and were associated
with meteorological factors, human population behavior patterns and diurnal variations.
Overall colder temperatures lead to higher concentrations of particle bound carbon and
the biogenic fraction nearly doubles as the temperature is lowered and inversion layers
are formed compared to the fossil carbon levels. BC had the highest linear correlation
coefficient with temperature indicating the strong temperature dependence of aerosol
mass from wood burning. Non-carbon species were not linearly dependent on
temperature. 12C/14C isotopic analysis of PM2.5 gave on average a biogenic carbon
fraction of 20 +/- 5 %, which is estimated to equal 43 - 53 % total wood burning
contribution. The conversion factor between BC mass and the total wood burning mass
was estimated to be between 2.1 – 2.4. At night all the aerosol fractions are linearly
dependent on the average temperature and during the day the relationship is non-linear.
Radiocarbon and levoglucosan measurements measured in Oslo during the sampling
period agree well. Further examination of the linear correlation between decreasing
temperature and carbon revealed that total carbon concentrations for each sample could
be modeled as a function of the hours below -4 oC as a critical temperature reflecting
all the parameters playing a part in aerosol formation in Oslo during the winter.
Biography
Prof. Peter B. Kelly graduated from Dartmouth College Cum Laude in
1976. Prof. Kelly received his PhD from the Pennsylvania State
University in 1981. He joined Prof. Herschel Rabitz and Prof. Richard
Miles at Princeton University as a post-doctoral researcher. In 1983 he
joined the research effort of Prof. Bruce S. Hudson at the University of
Oregon. Prof. Kelly joined the faculty at UC Davis in 1986. His
research interests focus on spectroscopy of small organic radicals,
analysis of combustion species, carbon-14 analysis methodology, and atmospheric chemistry.
General Information
CONFERENCE VENUE
CCME Central Multifunctional Room, College of Chemistry and Molecular
Engineering, Peking University
北京大学化学与分子工程学院 中区多功能厅
PRESENTATIONS
• The conference will be equipped with (1) window notebook with Microsoft
PowerPoint and Adobe Acrobat Reader, (2) LCD projector, (3) Laser pointer.
• Time Limit
Each presentation time indicated on the Program includes speech (~15 min) and Q&A
session (~10 min). Each student’s elevator pitch presentation is 3 min.
Please have a strict time control on your speech.
HOTEL INFORMATION
北京大学中关新园
Name: Zhongguanxinyuan Global Village of Peking University
Address: No. 126 North Zhongguancun Road, Hai Dian, 100871 Beijing, China
Phone: +86-10-62752288
EMERGENCY CONTACT
Prof. Wen-Bin Zhang Mobile: +86-13810312322
Dr. Guangzhong Yin Mobile: +86-13811992131
Direction to walk from the hotel to the meeting room:
Acknowledgements
We appreciate the funding supporting from the following agencies:
(1) The 111 project;
(2) ICAM;
(3) College of Chemistry and Molecular Engineering, Peking University;
(4) Center for Soft Matter Science and Engineering, Peking University;
(5) Daddy’s Choice Company.
