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Global & usa cancer immunotherapy market analysis to 2020

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YRH: GLOBAL & USA CANCER IMMUNOTHERAPY MARKET ANALYSIS TO 2020 Market Overview, Size, Share, Analysis, Technology Developments, Development Status, Trends, Structure, Production Value and Forecast Research Report Summary This report provides a comprehensive overview of the size of cancer immunotherapy market, the segmentation of the market, key players and the vast potential of therapies that are in clinical trials. Oncologic therapeutics cannot cure cancer and yet in 2014, the overall market for cancer therapeutics stood at about $84.3 billion. Any drug that can provide a reasonable survival of more than five years for the cancer patients can achieve a blockbuster status. Within the cancer therapeutics, the immunotherapeutic drugs have gained worldwide acceptance, because they are targeted drugs targeting only the cancer cells. Today, cancer immunotherapy drugs have captured nearly 50% of the overall oncology drugs market, generating about $41.0 billion in 2014 alone. This report describes the evolution of such a huge market in 11 chapters supported by 114 tables and 41 figures over 256 pages. • An overview of cancer immunotherapy that includes: monoclonal antibodies, cancer vaccines and non-specific cancer immunotherapies. • Focus on current trends in cancer immunotherapies that include: anti-PD-1 drugs, Dendritic cell vaccines, T-cell therapies and cancer vaccines. • Insight into the challenges faced by drug developers, particularly about the success vs. failure ratios in developing cancer immunotherapy drugs. • Descriptions about 23 cancer immunotherapeutics approved and used as targeted drugs (some of these products have already been withdrawn from the market). • Insight into the various immunotherapeutics available for specific cancer types. • Description and data for the prevalence of cancer types that are addressed by cancer immunotherapeutics. • Overall global cancer therapeutics market, leading market players and the bestselling cancer drugs. • Detailed account of the market for cancer immunotherapeutics by geography, indication, company and individual drugs. • Profiles, marketed products and products in pipeline of 76 companies that are mostly located in the U.S. and Europe. • Summary table to identify the category of immunotherapy drug offered by the 76 companies.
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Page 1: Global & usa cancer immunotherapy market analysis to 2020

YRH: GLOBAL & USA CANCER IMMUNOTHERAPY MARKET ANALYSIS TO 2020 Market Overview, Size, Share, Analysis, Technology Developments, Development Status, Trends, Structure, Production Value and Forecast Research Report Summary This report provides a comprehensive overview of the size of cancer immunotherapy market, the segmentation of the market, key players and the vast potential of therapies that are in clinical trials. Oncologic therapeutics cannot cure cancer and yet in 2014, the overall market for cancer therapeutics stood at about $84.3 billion. Any drug that can provide a reasonable survival of more than five years for the cancer patients can achieve a blockbuster status. Within the cancer therapeutics, the immunotherapeutic drugs have gained worldwide acceptance, because they are targeted drugs targeting only the cancer cells. Today, cancer immunotherapy drugs have captured nearly 50% of the overall oncology drugs market, generating about $41.0 billion in 2014 alone. This report describes the evolution of such a huge market in 11 chapters supported by 114 tables and 41 figures over 256 pages. • An overview of cancer immunotherapy that includes: monoclonal antibodies, cancer vaccines and non-specific cancer immunotherapies. • Focus on current trends in cancer immunotherapies that include: anti-PD-1 drugs, Dendritic cell vaccines, T-cell therapies and cancer vaccines. • Insight into the challenges faced by drug developers, particularly about the success vs. failure ratios in developing cancer immunotherapy drugs. • Descriptions about 23 cancer immunotherapeutics approved and used as targeted drugs (some of these products have already been withdrawn from the market). • Insight into the various immunotherapeutics available for specific cancer types. • Description and data for the prevalence of cancer types that are addressed by cancer immunotherapeutics. • Overall global cancer therapeutics market, leading market players and the bestselling cancer drugs. • Detailed account of the market for cancer immunotherapeutics by geography, indication, company and individual drugs. • Profiles, marketed products and products in pipeline of 76 companies that are mostly located in the U.S. and Europe. • Summary table to identify the category of immunotherapy drug offered by the 76 companies.

Page 2: Global & usa cancer immunotherapy market analysis to 2020

The report is supported by 155 tables & figures over 246 pages. This report is presented as follows: The global market for cancer immunotherapy by the following sub-categories are presented: • By Segment (Monoclonal Antibodies, Cancer Vaccines, Non-Specific Therapies, Checkpoint Inhibitors) • By Product Segment (Antibody Drug Conjugates (ADCs), Bispecific Monoclonal Antibodies, Cytokines, Interferons, Chimeric Antigen Receptor (CAR) T-Cell Therapy, PD-1/PD-L1 inhibitors, Dendritic Cells, Adopted Cell Therapy (ACT) & IDO Inhibitors • By Company (e.g Amgen, Merck, Eli Lilly, GlaxoSmithKline, Janssen, Genentech, Roche, Bristol Myers Squibb) A comprehensive account of company product portfolios are provided for 78 Cancer Immunotherapy pharma and biotech companies including: • Amgen Inc. • Biogen Idec Inc.x • Bristol-Myers Squibb Co. • Cellectis • Cellerant Therapeutics Inc. • Celldex Therapeutics • Eli Lilly and Co. • EMD Serono Inc. • Genentech Inc. • Genmab AS • GlaxoSmithKline • ImmunoGen Inc. • Immunomedics Inc. • Janssen Biotech Inc. • Juno Therapeutics Inc. • Merck & Co., Inc. • Oxford BioTherapeutics Ltd. • Progenics Pharmaceuticals Inc. • Roche Holdings Inc. • Seattle Genetics Inc. • Sorrento Therapeutics Inc. Key Questions Answered in this Report • What are the three types of cancer immunotherapies? • What are the immunotherapies approved between 1986 and 2014? • What are the monoclonal antibodies (MAbs) approved by FDA to treat different types of cancers? • What are naked MAbs and how many of them have been approved by FDA? • What are antibody-drug conjugates (ADCs) and how many of them are available in the market? • What are the common cytotoxic “warheads” used in ADCs?

Page 3: Global & usa cancer immunotherapy market analysis to 2020

• What are the important clinical assets in ADCs? • How many bispecific MAbs are in late-stage development? • What are the common side effects of MAbs in cancer immunotherapy? • What are cancer vaccines and how many of them have been licensed to be marketed? • How many cytokines have been approved for being used in cancer immunotherapy? • What are the major checkpoint inhibitors in clinical development? • What is the current status of anti-PD-1 drugs, dendritic cell therapies, T-cell therapies and cancer vaccines? • What are the most valuable R&D projects in cancer immunotherapy and what would be their approximate sales revenues in 2020? • Number of melanoma drugs approved between 1998 and 2014? • Number of lung cancer drugs approved between 1998 and 2014? • Number of brain cancer drugs approved between 1998 and 2014? • What is the global market for cancer immunotherapeutics by geography, through 2020? • What is the global market for cancer immunotherapeutics by product class such as MAbs, vaccines and non-specific immunotherapies, through 2020? • What is the global market for cancer immunotherapeutics by indication, through 2020? • What is the global market for MAbs by type such as naked MAbs and ADCs, through 2020? • What are the market values for Herceptin, Avastin, Erbitux, Yervoy, Mabthera, Adectris, and Keytruda? • What is the global market for cancer vaccines? Get Full Report With Table Of Contents at

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Table of contents

1.0 Executive Summary 13

1.1 Objectives of Report 14

1.1 Key Questions Answered in this Report 14

1.2 Data Sources and Methodology 15

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2.0 Cancer Immunotherapy: An Overview 16

Page 4: Global & usa cancer immunotherapy market analysis to 2020

2.1 Human Immune System 16

2.1.1 Components of Human Immune System 17

2.2 Types of Cancer Immunotherapy 18

2.3 Monoclonal Antibodies (Mabs) to Treat Cancer 19

2.3.1 Most Frequently Targeted Antigens by MAbs 19

2.4 Types of Monoclonal Antibodies (MAbs) 21

2.4.1 Naked MAbs 21

2.4.2 Conjugated Monoclonal Antibodies 22

2.4.2.1 Components of an Antibody Drug Conjugate (ADC) 22

2.4.2.2 Mechanism of Action of Antibody Drug Conjugate (ADC) 23

2.4.2.3 The Cytotoxic Warheads used in ADCs 23

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2.4.2.4 Successful Cytotoxin Warheads 24

2.4.2.5 Developmental Timeline of ADCs 25

2.4.2.6 Target Antigens for ADCs in Preclinical and Clinical Development 26

2.4.2.7 Important Clinical Assets in ADCs 26

2.4.3 Bispecific Monoclonal Antibodies 28

2.4.3.1 Technology Platforms for the Production of Bispecific MAbs 29

2.4.4 Safety and Side Effects of MAbs in Cancer Immunotherapy 29

2.5 Cancer Vaccines 30

2.5.1 Cancer Vaccines in Development 31

2.6 Non-Specific Cancer Immunotherapies and Adjuvants 34

2.6.1 Cytokines 34

2.6.1 Interferon (IFN) 34

2.7 New Frontiers in Cancer Immunotherapy Research 35

2.7.1 Drugs for Targeting Immune Checkpoints 35

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2.7.1.1 Cytotoxic T-Lymphocyte-Associated Protein-4 (CTLA-4) 35

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2.7.1.2 Programmed Death 1 (PD-1) and Programmed Death Ligand 1 (PD-L1) 35

2.7.1.3 Major Checkpoint Inhibitors in Clinical Development 35

2.7.2 Chimeric Antigen Receptor (CAR) T Cell Therapy 36

2.7.3 Tumor-Infiltrating Lymphocytes (TILs) and Interleukin-2 (IL-2) 36

2.8 Cancer Immunotherapy: Timeline of Progress 36

3.0 Current Status of Cancer Immunotherapy: An Overview 40

3.1 Programmed Death (PD-1) Inhibitors 40

3.1.1 Important Events and Advantages for Nivolumab in Melanoma Indication 41

3.1.2 Important Events and Advantages for Nivolumab in Non-Small Cell Lung Cancer 42

3.1.3 Important Events and Advantages for Nivolumab in Renal Cell Cancer 42

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3.1.4 Nivolumab Studies for Melanoma 42

3.1.5 Nivolumab Studies for Non-Small Cell Lung Cancer (NSCLC) 43

3.1.6 Nivolumab Studies for Renal Cell Cancer (RCC) 43

3.2 MK-3475 (Pembrolizumab) 43

3.2.1 Important Events and Advantages for MK-3475 in Melanoma 43

3.2.2 Important Events and Advantages for MK-3475 in NSCLC 44

3.2.3 Important Events for MK-3475 in RCC 44

3.3 RG7446 from Roche 45

3.3.1 Important Events for RG7446 in Melanoma 45

3.3.2 Important Events and Advantages for RG7446 in NSCLC 45

3.3.3 Important Event for RG7446 in RCC 46

3.3.4 RG7446 Studies in NSCLC 46

3.3.5 RG7446 Studies in RCC 46

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3.3.6 RG7446 Study in RCC 47

3.4 Pidilizumab from CureTech 48

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3.5 An Overview of Anti-PD-1 Clinical Development 48

3.5.1 Other Checkpoint Inhibitors in Development 50

3.6 Studies with Yervoy (Ipilimumab) 50

3.7 Studies with Tremelimumab 52

3.8 KAHR-102 52

3.9 TIM3 Antibody 52

3.10 BMS-989016 52

3.11 ImmuTune IMP701 and ImmuFact IMP321 53

3.12 Dendritic Cell Therapies 53

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3.12.1 Provenge (Sipuleucel-T) 54

3.12.2 AGS-003 from Argos Therapeutics 54

3.12.3 DCP-001 from DCPrime 55

3.12.4 DC-Vax from Northwest Biotherapeutics 55

3.13 Chimeric Antigen Receptor T-Cells (CAR-T) Therapies 55

3.13.1 CLT109 55

3.13.2 Chimeric Antigen Receptors (CAR) Program by Juno 56

3.13.3 Chimeric Antigen Receptor (CAR) T-Cell Program by Bluebird Bio 56

3.13.4 UCART19 from Cellectis 56

3.13.5 Chimeric Immune Receptor (CIR) T-Cells from Abramson Cancer Center 57

3.13.6 CD19 eACT CAR-T Therapy from Kite Pharma 57

3.13.7 Autologous CAR-T Program for Breast Cancer from Adaptimmune 57

3.14 Cancer Vaccines 57

3.14.1 HyperAcute 59

3.14.2 MAGE-A3 Antigen-Specific Cancer Immunotherapeutic 59

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3.14.3 ADXS-HPV 59

3.14.4 IDO Inhibitors 60

3.14.5 Indoximod and NLG-919 (INCY) 60

3.14.6 INCB24360 (INCY) 60

3.14.7 deCellVax (BMSN) 60

3.15 Miscellaneous Immunotherapies 61

3.15.1 Contego (Lion Biotechnologies) 61

3.15.2 TG4010 (Transgene) 61

3.16 Most Valuable R&D Projects in Cancer Immunotherapy 61

3.16.1 Nivolumab (Opdivo) 62

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3.16.2 MK-3475 62

3.16.3 RG7446 62

3.16.4 Palbociclib 63

3.16.5 DCVax-L 63

3.16.6 MEDI4736 63

4.0 Challenges in Cancer Medicine Research: An Overview 64

4.1 Years of Failures and Emerging Successes in Melanoma Medicine Research 64

4.1.1 Future Outlook for Melanoma Drugs 65

4.2 A New Era for Lung Cancer Medicines 66

4.2.1 Progresses Made in Lung Cancer Medicine Research 66

4.2.2 Successes and Failures in Lung Cancer Medicine Development 67

4.2.3 Future Outlook for Lung Cancer Medicines 67

4.3 Ray of Hope for Brain Cancer Patients 68

4.3.1 Progress made for Brain Cancer Treatment in Recent Years 68

4.3.2 Successes and Failures in Brain Cancer Drug Development 68

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5.0 Cancer Immunotherapeutic Products: An Overview 70

5.1 I-Labelled Tositumomab (Bexxar) 70

5.2 Y-Labelled Ibritumomab (Zevalin) 70

5.3 Alemtuzumab (Campath) 71

5.4 Adotrastuzumab Emtansine (Kadcyla) 71

5.5 Bacillus Calmette-Guerin (BCG) 72

5.6 Bevacizumab (Avastin) 72

5.7 Brentuximab Vedotin (Adcetris) 72

5.8 Cetuximab (Erbitux) 73

5.9 Cervarix 73

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5.10 Denileukin Diftitox (Ontak) 74

5.11 Gardasil 74

5.12 Gemtuzumab (Mylotarg) 74

5.13 Hepatitis B Vaccine 74

5.14 Interferon Alfa (IFN-alfa) 74

5.15 Interleukin-2 (IL-2) 75

5.16 Ipilimumab (Yervoy) 75

5.17 Ofatumumab (Arzerra) 75

5.18 Panitumumab (Vectibix) 75

5.19 Pembrolizumab (Keytruda) 75

5.20 Rituximab (Mabthera) 76

5.21 Sargramostim (Leukine) 76

5.22 Sipuleucel-T (Provenge) 76

5.23 Trastuzumab (Herceptin) 76

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6.0 Available Immunotherapies for Cancer by Disease Type: An Overview 78

6.1 Melanoma Skin Cancer and Immunotherapy 79

6.1.1 Ipilimumab (Yervoy) for Advanced Melanoma 79

6.1.2 PD-1 Inhibitors (Keytruda and Opdivo) for Advanced Melanoma 79

6.1.3 Cytokines for Advanced Melanoma 79

6.1.4 Interferon Alfa as Adjuvant Therapy for Melanoma 79

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6.1.5 Bacille Calmette-Guerin (BCG) Vaccine for Melanoma 80

6.1.6 Imiquimod (zyclara) Cream for Melanoma 80

6.2 Breast Cancer and Immunotherapy 80

6.2.1 Promising Therapeutic Vaccine Product Candidates for Breast Cancer 80

6.2.2 Promising Checkpoint Inhibiting Product Candidates for Breast Cancer 81

6.2.3 Promising Adoptive T Cell Therapy Product Candidates for Breast Cancer 81

6.2.4 Promising Antibody Product Candidates for Breast Cancer 81

6.3 Immunotherapy for Prostate Cancer 81

6.3.1 Therapeutic Vaccines for Prostate Cancer 82

6.3.2 Checkpoint Inhibitors for Prostate Cancer 83

6.3.3 Adoptive Cell Therapy for Prostate Cancer 84

6.4 Immunotherapy for Lung Cancer 84

6.4.1 Monoclonal Antibodies for Lung Cancer 84

6.4.1.1 Promising MAb Product Candidates for Lung Cancer 84

6.4.1.2 Checkpoint Inhibitors for Lung Cancer 85

6.4.1.3 Therapeutic Vaccines for Lung Cancer 87

6.4.1.4 Promising Adoptive T Cell Transfer Product Candidates for Lung Cancer 87

6.5 Immunotherapy for Colorectal Cancer 88

6.5.1 Promising Monoclonal Antibody Product Candidates for Colorectal Cancer 88

6.5.2 Trials Using Checkpoint Inhibitors and Immune Modulators for Colorectal Cancer 88

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6.5.3 Clinical Trials for Vaccines Indicated for Colorectal Cancer 89

6.5.4 Adoptive Cell Therapy for Colorectal Cancer 90

6.5.5 Oncolytic Virus Therapy for Colorectal Cancer 90

6.5.6 Adjuvant Immunotherapy for Colorectal Cancer 90

6.5.7 Cytokines for Colorectal Cancer 90

6.6 Immunotherapies in Development for Lymphoma 91

6.6.1 Therapeutic Vaccines in Development for Lymphoma 91

6.6.2 Checkpoint Inhibitors for Lymphoma 91

6.6.3 Adoptive T Cell Transfer for Lymphoma 91

6.6.4 Monoclonal Antibodies for Lymphoma 92

6.7 Immunotherapy for Kidney Cancer 92

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6.7.1 Checkpoint Inhibitors for Kidney Cancer 92

6.7.2 Vaccines for Kidney Cancer 92

6.7.3 Adoptive Cell Therapy for Kidney Cancer 93

6.8 Dominance of MAbs and Vaccines in Cancer Clinical Research 93

6.9 Oncology Biologics Losing Patent Protection 93

7.0 Cancer Incidence and Mortality: An Overview 95

7.1 Global Economic Burden of Cancer 95

7.2 Global Burden of Cancer 96

7.3 Top Five Most Frequent Cancers, Globally 96

7.3.1 Global Prevalence of Colorectal, Breast and Lung Cancers 97

7.3.2 Percentage of Top Three Cancers Diagnosed Globally 97

7.3.2.1 Mortality due to Lung, Liver and Stomach Cancers 98

7.3.2.2 Percentage of Death due to Lung, Liver and Stomach Cancers 99

7.4 Cancer Deaths in Women 99

7.5 Prevalence and Mortality for Cancer Types Addressed by Immunotherapy 100

7.5.1 Breast Cancer 100

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7.5.1.1 Worldwide Incidence of Breast Cancer and Mortality Rate by Geography 101

7.5.1.2 Female Breast Cancer Incidence in the U.S. 101

7.5.1.3 Five Year Breast Cancer Survival Rates by Stage at Diagnosis and Age in the U.S. 102

7.5.1.4 Breast Cancer Incidence in Canada 103

7.5.1.5 Breast Cancer Incidence and Mortality in Latin America 103

7.5.1.6 Breast Cancer Incidence and Mortality in Europe 104

7.5.1.7 Breast Cancer Incidence in Asia/Pacific 105

7.5.1.8 Breast Cancer Incidence by Country 106

7.5.2 Gastric Cancer (Stomach Cancer) 110

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7.5.2.1 Incidence of Gastric Cancer in Top 15 Countries 110

7.5.3 Colorectal Cancer 111

7.5.3.1 Global Incidence of Colorectal Cancer 111

7.5.3.2 Worldwide Variations in the Incidence of Colorectal Cancer 112

7.5.3.3 Risk Factors for Colorectal Cancer 113

7.5.3.4 Colorectal Cancer Screening in the U.S. 114

7.5.3.5 Colorectal Cancer Incidence Rates in the U.S. by State 114

7.5.3.6 Colorectal Cancer Mortality Rates (per 100,000) in the U.S. by States 115

7.5.4 Lung Cancer 116

7.5.4.1 Non-Small Cell Lung Cancer (NSCLC) 117

7.5.4.2 Global NSCLC Incidence 118

7.5.4.3 Lung Cancer in Americas by Gender 118

7.5.4.4 Tobacco Use and Lung Cancer 119

7.5.4.5 Current Therapeutic Options for Lung Cancer 120

7.5.5 Glioblastoma 122

7.5.5.1 Global Incidence of Glioblastoma 122

7.5.6 Kidney Cancer 123

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7.5.6.1 Global Incidence of Kidney Cancer 124

7.5.7 Blood Cancer 125

7.5.7.1 Leukemia 125

7.5.7.2 Blood Cancer in the U.S. 126

7.5.8 Cervical Cancer 128

7.5.8.1 Global Incidence of Cervical Cancer 128

7.5.9 Prostate Cancer 129

7.5.9.1 Global Incidence of Prostate Cancer 129

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7.5.9.2 Prostate Cancer Incidence and Mortality by Geography 130

7.5.9.3 Prostrate Cancer in the U.S. 131

7.5.10 Melanoma 132

7.5.10.1 Skin Cancer in the U.S. 133

8.0 Market Analysis 134

8.1 Global Oncology Market 134

8.2 Top Ten Companies in Oncology Drug Sales 135

8.3 Top Five Oncology Drugs 136

8.4 Global Oncology Therapeutics Market by Cancer Type 137

9.0 Market for Cancer Immunotherapy 139

9.1 Key Drivers 139

9.2 Global Market for Cancer Immunotherapeutics 139

9.3 Global Market for Cancer Immunotherapy by Product Class 141

9.4 Global Market for Immunotherapy Drugs by Cancer Type 142

9.5 Global Market for Monoclonal Antibodies for Cancer by Type 143

9.5.1 Best Selling MAbs 144

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9.5.1.1 Market Forecast for Herceptin 144

9.5.1.2 Market Value and Forecast for Avastin 145

9.5.1.3 Global Market for Erbitux 146

9.5.1.4 Global Market for Yervoy 147

9.5.1.5 Global Market for Mabthera 148

9.5.2 Global Market for Antibody Drug Conjugates (ADCs) 149

9.5.2.1 MGlobal Market for Adcetris 149

9.5.2.1 Global Market for Keytruda 150

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9.6 Global Market for Cancer Vaccines 151

9.6.1 Global Market for Cancer Vaccines by Type 152

9.7 Global Market for Non-Specific Cancer Immunotherapeutics 154

9.8 Market Values for Selected Forthcoming Cancer Immunotherapeutics 155

9.8.1 Market Value for Nivolumab (Opdivo) 155

9.8.2 Market Value for RG7446 155

9.8.3 Market Value for DCVax-L 155

9.8.4 Market Value for MEDI4736 156

9.8.5 High Cost of MAbs 156

10.0 Company Profiles 157

10.1 Ablynx NV 157

10.2 Activartis Biotech GmbH 158

10.2.1 GBM Vax Study 158

10.3 Advaxis Inc. 158

10.3.1 Advaxis’ Technology 159

10.3.2 Advaxis’ Product Pipeline 159

10.3.2.1 ADXS-HPV 159

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10.3.2.2 ADXS-PSA 159

10.3.2.3 ADXS-cHER2 159

10.4 Aduro BioTech Inc. 160

10.4.1 Aduro’s Technology 160

10.4.1.1 CRS-207 161

10.4.1.2 AUD-623 161

10.4.1.3 ADU-741 161

10.4.1.4 ADU-S100 161

10.5 Agenus Inc. 162

10.5.1 QS-21 Stimulon 162

10.6 AlphaVax Inc. 163

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10.6.1 Alpha Vax’s Technology 163

10.7 A. Menarini Industrie Farmaceutiche Riunite Srl 163

10.7.1 MEN1112 164

10.8 Amgen Inc. 164

10.8.1 Vectibix (panitumumab) 164

10.8.2 Blinatumomab (Blincyto) 164

10.8.3 Rilotumumab 165

10.9 Antigen Express Inc. 165

10.9.1 Li-Key Hybrid Vaccines (AE37) 165

10.10 Argos Therapeutics Inc. 166

10.10.1 AGS-003 166

10.11 Bavarian Nordic A/S 167

10.11.1 Prostvac 167

10.11.2 CV-301 167

10.11.3 MVA-BN PRP 168

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10.11.4 MVA-BN HER2 168

10.11.4 MVA-BN Brachyury 168

10.12 Bellicum Pharmaceuticals Inc. 168

10.12.1 BPX-501 168

10.12.2 BPX-201 169

10.12.3 BPX-401 169

10.12.4 BPX-601 169

10.12.5 BPX-701 169

10.13 Biogen Idec Inc. 170

10.13.1 Rituxan (Rituximab) 170

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10.13.2 Gazyva (Obinutuzumab) 170

10.14 Biovest International Inc. 171

10.14.1 BiovaxID 171

10.15 Bristol-Myers Squibb Company 171

10.15.1 Erbitux (cetuximab) 172

10.15.2 OPDIVO (nivolumab) 172

10.15.3 Yervoy (ipilimumab) 172

10.16 Cellectis 172

10.17 Cellerant Therapeutics Inc. 173

10.17.1 CLT-008 174

10.17.2 CLT-009 174

10.18 Celldex Therapeutics 174

10.18.1 Rindopepimut 174

10.18.2 Glembatumumab vedotin (CDX-011) 175

10.18.3 Varlilumab (CDX-1127) 175

10.18.4 CDX-1401 175

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10.18.5 CDX-301 175

10.19 CEL-SCI Corp. 175

10.19.1 Multikine 176

10.20 CureTech Ltd. 176

10.20.1 Pidilizumab (CT-011) 176

10.21 Delta-Vir GmbH 177

10.21.1 Treatment 177

10.22 Dendreon Corp. 177

10.22.1 Provenge (Sipuleucel-T) 177

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10.23 DenDrit Biotech USA 178

10.23.1 MelCancerVac 178

10.24 DNAtrix Inc. 178

10.24.1 DNX-2401 178

10.25 Eli Lilly and Co. 179

10.25.1 Erbitux (Cetuximab) 179

10.26 EMD Serono Inc. 179

10.27 Etubics Corp. 180

10.28 Galena Biopharma Inc. 181

10.29 Genentech Inc. 181

10.29.1 Avastin (bevacizumab) for Metastatic Colorectal Cancer 182

10.29.1.1 Avastin and Interferon Alfa for Metastatic Kidney Cancer 182

10.29.1.2 Avastin for Metastatic NLCLC 182

10.29.2 Gazyva (obinutuzumab) for Chronic Lymphocytic Leukemia 182

10.29.3 Herceptin (trastuzumab) for Breast Cancer 182

10.29.3.1 Herceptin and Chemotherapy for Gastric Cancer 183

10.29.4 Kadcyla (ado-trastuzumab emtansine) 183

10.29.5 Perjeta (pertuzumab) 183

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10.29.6 Rituxan (rituximab) 183

10.29.7 Genentech’s Cancer Immunotherapy Pipeline Products 184

10.30 Genmab AS 185

10.30.1 Ofatumumab 185

10.31 GlaxoSmithKline 186

10.31.1 Arzerra (Ofatumumab) 186

10.31.2 Cervarix 186

10.32 Gliknik Inc. 186

10.33 GlobeImmune Inc. 187

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10.34 Heat Biologics Inc. 188

10.35 Immatics Biotechnologies GmbH 188

10.36 ImmunoCellular Therapeutics Ltd. 189

10.37 Immunocore Ltd. 190

10.37.1 Product Pipeline 190

10.38 ImmunoFrontier Inc. 190

10.39 ImmunoGen Inc. 191

10.39.1 IMGN853 191

10.39.2 IMGN529 191

10.39.3 IMGN289 191

10.39.4 IMGN779 191

10.40 Immunomedics Inc. 192

10.41 Immunotope Inc. 192

10.41.1 IMT-1012 Immunotherapeutic Vaccine 193

10.42 Immunovaccine Inc. 193

10.43 Inovio Pharmaceuticals Inc. 194

10.44 Janssen Biotech Inc. 194

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10.44.1 Doxil 194

10.44.2 Procrit 195

10.44.3 Zytiga 195

10.44.4 Imbruvicia 195

10.45 Juno Therapeutics Inc. 195

10.46 Kite Pharma Inc. 196

10.46.1 Kite Pharma’s Technology 196

10.46.1.1 eACT (engineered Autologous Cell Therapy) 196

10.46.1.2 DC-Ad GM-CAIX 196

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10.47 MabVax Therapeutics Holdings Inc. 197

10.48 MedImmune LLC 198

10.49 Merck & Co., Inc. 199

10.49.1 Gardasil (Human Papillomavirus Quadrivalent (Types 6, 11, 16 and 18) Vaccine 199

10.49.2 Keytruda (Pembrolizumab) 199

10.50 Merrimack Pharmaceuticals Inc. 200

10.51 Morphotek Inc. 200

10.51.1 Farletuzumab (MORAb-003) 201

10.51.2 Amatuximab (MORAb-009) 201

10.51.3 Ontuxizumab (MORAb-004) 201

10.51.4 MORAb-066 201

10.52 NewLink Genetics Corp. 201

10.53 Northwest Biotherapeutics Inc. 202

10.54 NovaRx Corp. 203

10.55 OncoPep Inc. 203

10.55.1 PVX-410 203

10.56 Oncothyreon Inc. 204

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10.57 OSE Pharma SA 204

10.58 Oxford BioTherapeutics Ltd. 205

10.58.1 Technologies 205

10.58.1.1 OGAP – Cancer Targeting 205

10.58.1.2 Antibody Development 205

10.58.1.3 Antibody “arming” 206

10.58.2 Lead Programs 206

10.58.2.1 OX001/MEN1112 206

10.58.2.2 OX002 206

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10.58.2.3 OX003 206

10.58.2.4 OX004 206

10.59 Pique Therapeutics 207

10.60 Polynoma LLC 207

10.60.1 MAVIS Trial 207

10.61 Prima BioMed Ltd. 208

10.62 Progenics Pharmaceuticals Inc. 208

10.62.1 PSMA Targeted Imaging Compound (1404) 209

10.62.2 PSMA ADC Therapeutic 209

10.62.3 Small Molecule Therapeutic (1095) 209

10.62.4 Azedra 209

10.63 Regen Biopharma Inc. 210

10.63.1 HemaXellerate 210

10.63.2 dCellVax 210

10.63.3 Diffron C 210

10.64 Roche Holdings Inc. 211

10.64.1 Avastin (Bevacizumab) 211

10.64.2 Gazyva/Gazyvaro (Obinutuzumab; GA101) 211

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10.64.3 Herceptin (Trastuzumab) 211

10.64.4 Kadcyla (Trastuzumabum emtansinum) 211

10.64.5 Mabthera (Rituximab) 211

10.64.6 Perjeta (Pertuzumab) 212

10.65 Seattle Genetics Inc. 213

10.65.1 Adcetris (Brentuximab vedotin) 214

10.65.2 Seattle Genetics’ Collaborarator Pipeline 214

10.66 Sorrento Therapeutics Inc. 215

10.66.1 Sorrento’s Antibody Technologies 216

10.66.1.1 G-MAB 216

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10.66.1.2 Antibody Drug Conjugates (ADCs) 216

10.67 Spectrum Pharmaceuticals Inc. 216

10.67.1 Zevalin 216

10.68 Synthon Pharmaceuticals Inc. 217

10.69 TapImmune Inc. 217

10.70 ThioLogics Ltd. 218

10.71 Transgene SA 219

10.72 TVAX Biomedical Inc. 219

10.72.1 TVI-Brain-1 220

10.72.2 TVI-Kidney-1 220

10.73 Vaccinogen Inc. 220

10.74 Viventia Biotechnologies Inc. 221

10.75 Wilex AG 221

10.76 Ziopharm Oncology Inc. 222

11.0 Cancer Immunotherapy Market Participants by Product Segment 223

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INDEX OF FIGURES

Figure 2.1: Components of an Antibody Drug Conjugate (ADC) .

Figure 2.2: Mechanism of Action of Antibody Drug Conjugates .

Figure 2.3: Ranking of Commonly Used Cytotoxin Warheads .

Figure 4.1: Number of Successful and Unsuccessful Melanoma Drugs, 1998-2014 .

Figure 4.2: Successes and Failures in Lung Cancer Medicine Development, 1998-2014 .

Figure 4.3: Successes and Failures in Brain Cancer Drug Development, 1998-2014 .

Figure 5.1: Ibritumomab Linked to Yttrium Radfionucleotide .

Figure 5.2: Kadcyla (Trastuzumab + DMI) .

Figure 6.1: Dominance of MAbs and Vaccines in Cancer Clinical Research .

Figure 7.1: Global Economic Burden of Cancer .

Figure 7.2: Number of Colorectal, Breast and Lung Cancer Cases Diagnosed Globally, 2012 .

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Figure 7.3 Percentage of Top Three Cancers Diagnosed Globally, 2012 .

Figure 7.4: Number of Deaths due to Lung, Liver and Stomach Cancers Globally, 2012 .

Figure 7.5: Percentage of Deaths due to Lung, Liver and Stomach Cancers, 2012 .

Figure 7.6: Global Cancer Deaths in Women by Type of Cancer .

Figure 7.7: Worldwide Incidence of Female Breast Cancer and Mortality Rate by Geography .

Figure 7.8: Five Year Relative Breast Cancer Survival Rates by Stage at Diagnosis and Age in

theU.S. .

Figure 7.9: Breast Cancer Incidence and Mortality in Latin America .

Figure 7.10: Breast Cancer Incidence and Mortality in Europe .

Figure 7.11: Breast Cancer Incidence Rates in Asia/Pacific Region .

Figure 7.12: Top 15 Countries in Gastric Cancer Incidence .

Figure 7.13: Top 15 Countries in Colorectal Cancer Incidence .

Figure 7.14: Adults Aged 50-75 Years (%) That are Up-to-Date with Colorectal Screening Tests

by State in the U.S. .

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Figure 7.15 Colorectal Cancer Incidence Rates (per 100,000) by State in the U.S. .

Figure 7.16: Colorectal Cancer Mortality Rates (per 100,000) in the U.S. by States .

Figure 7.17: Top 15 Countries with Lung Cancer .

Figure 7.18: Global NSCLC Incidence .

Figure 7.19: Number of Smokers in China, India, Russia, the U.K. ans U.S. .

Figure 7.20: Global Incidence of Glioblastoma .

Figure 7.21: Global Incidence of Kidney Cancer .

Figure 7.22: Top 15 Countries in Leukemia Mortality .

Figure 7.23: Five Year Survival Rates in the U.S. for Blood Cancer Patients .

Figure 7.24 Top 15 Countries in Cervical Cancer .

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Figure 7.25: Top 15 Countries with Prostate Cancer .

Figure 7.26: Skin Cancer Death Rates for Top 15 Countries .

Figure 8.1: Global Market for Oncology Drugs by Geography/Country, Through 2020 .

Figure 8.2: Global Oncology Drug Sales by Top Five Companies, Through 2020 .

Figure 8.3: Top Five Oncology Drugs, Through 2020 .

Figure 8.4: Global Oncology Therapeutics Market by Cancer Type, 2014 .

Figure 9.1: Global Cancer Immunotherapy Market, Through 2020 .

Figure 9.2: Global Market for Immunotherapy by Product Class, Through 2020 .

Figure 9.3: Global Market for Immunotherapy Drugs by Cancer Type, Through 2020 .

Figure 9.4: Global Market for Monoclonal Antibodies for Cancer by Type, Through 2020 .

Figure 9.5: Global and U.S. Market for Herceptin, Through 2020 .

Figure 9.6: Global and U.S. Market for Avastin, Through 2020 .

Table 9.7: Global Market for Erbitux, Through 2020 .

Figure 9.8: Global Market for Yervoy, Through 2020 .

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Figure 9.9: Global Market for Mabthera, Through 2020 .

Figure 9.10: Global Market for Adcetris, Through 2020 .

Figure 9.11: Global Market for Keytruda, Through 2020 .

Figure 9.12: Global Market for Cancer Vaccines, Through 2020 .

Figure 9.13: Global Market for Cancer Vaccines by Type, Through 2020 .

Figure 9.14: Global Market for Cytokine Drugs for Cancer, Through 2020 .

INDEX OF TABLES

Table 2.1: Types of Immune Cells and their Functions .

Table 2.2: FDA-Approved Cancer Immunotherapies, 1986-2014 .

Table 2.3: FDA-Approved Monoclonal Antibodies (MAbs) to Treat Cancer .

Table 2.4: Most Frequently Targeted Antigens by MAbs .

Table 2.5: FDA-Approved Monoclonal Antibodies .

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Table 2.6: Cytotoxic Warheads Used in ADCs .

Table 2.7: Targeted Indications for ADCs .

Table 2.8: Antibody Drug Conjugates: Developmental Tmeline .

Table 2.9: Target Antigens for ADCs in Preclinical and Clinical Development .

Table 2.10: Current ADCs Launched, Withdrawn and in Phase I/II/III Trials by Sponsor,

Indication, Antigen, Cytotoxin and Linker .

Table 2.11: MAb Products and Candidates that Recruit T Cells .

Table 2.12: Bispecific MAbs in Clinical Trials Targeting Cancer by Indication and Company .

Table 2.13: Bispecific Antibody Technology Platforms .

Table 2.14: Side Effects of Some of the Approved Cancer Immunotherapy MAbs .

Table 2.15: FDA-Approved Cancer Vaccines .

Table 2.16: Cancer Vaccines in Development .

Table 2.17: FDA-Approved Cytokines for Cancer Immunotherapy .

Table 2.18: Cancer Indications Approved for IFN-alfa .

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Table 2.19: FDA-Approved Immune Checkpoint Modulators .

Table 2.20: Immune Checkpoint Inhibitors in Clinical Development .

Table 2.21: Cancer Immunotherapy: Timeline of Progress .

Table 3.1: PD-1 Therapies Targeting either the PD-L1/L2 or PD-1 Receptor .

Table 3.2: Overview of Clinical Trial Landscape for Top Five Anti-PD-1 and Anti-PD-L1 Drug

Table 3.3: Nivolumab Efficacy from Expansion Coharts of Study 003 .

Table 3.4: Phase I Data of MK-3475 in Melanoma .

Table 3.5: Phase I Data of RG7446 in NSCLC Patients .

Table 3.6: RG7446 Phase I Data from RCC Patients .

Table 3.7: Phase I Melanoma Data for RG7446 .

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Table 3.8: Phase II Data for Pidilizumab in Diffuse Large B Cell Lymphoma (DLBCL) .

Table 3.9: Phase II Melanoma Data for Pidilizumab .

Table 3.10: An Overview of Anti-PD-1 Development by Company, Drug Candidate, Indication

and Clinical Phase .

Table 3.11: Clinical Development of CTLA-4, TIM3, and LAG3 Checkpoint Inhibitors by

Company, Drug Candidate, Indication and Clinical Trial Stage .

Table 3.12: Pivotal Phase III Results for Yervoy in Second-Line Patients with Metastatic

Melanoma

Table 3.13: Updated Data from Phase III Clinical Study 024 for Yervoy .

Table 3.14: Data from the Failed Phase III Study of Tremelimumab for Melanoma .

Table 3.15: An Overview of Clinical Development of Dendritic Cell Therapies by Company,

Drug Candidate, Indication and Clinical Phase .

Table 3.16: Pivotal Phase III Rwesults for Yervoy in Second-Line Patients with Metastatic

Melanoma .

Table 3.17: Phase I/Iia Results from Kite Pharma’s CAR-T Therapy .

Table 3.18: Cancer Vaccines in Development by Company, Drug Candidate, Indication and

Clinical Phase .

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Table 3.19: Advaxis Phase II Results for Cervical Cancer Patients in India .

Table 3.20: Phase II Data for Contego .

Table 3.21: Valuable R&D Projects in Cancer Immunotherapy .

Table 6.1: Cancer Types Addressed by Immunotherapies by Drug, Trade Name and Company .

Table 6.2: Oncology Drugs Losing Patent Protection by 2020 by Product, U.S. Expiry Date and

E.U. Expiry Date .

Table 7.1: Global Cancer Statistics – Key Facts .

Table 7.2: Top Five Most Frequent Cancers, Globally .

Table 7.3: Estimated Breast Cancer Cases and Deaths in the U.S. by Age, 2013 .

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Table 7.4: Estimated Canadian Breast Cancer Statistics for 2014 .

Table 7.5: Age-Standardized Breast Cancer Incidence Rate per 100,000 Women by Country .

Table 7.6: Global Colorectal Cancer Incidence and Mortality Rates by Gender per 100,000

people .

Table 7.7: Risk Factors for Colorectal Cancer .

Table 7.8: Lung Cancer Incidence and Mortality Rate in Americas by Gender .

Table 7.9: Current Therapeutic Options for Lung Cancer .

Table 7.10: Estimated Number of New Leukemia Cases in the U.S., 2014 .

Table 7.11: Estimated Deaths in the U.S. from Leukemia, 2014 .

Table 7.12: Estimated Deaths from HL and NHL in the U.S., 2014 .

Table 7.13: Estimated Incidence and Deaths for Myeloma in the U.S., 2014 .

Table 7.14 Global Prostate Cancer Incidence and Mortality Rates by Geography .

Table 7.15: Incidence and Mortality Rates of Prostate Cancer in Americas .

Table 7.16: Incidence and Mortality Rates for Melanoma in Americas .

Table 8.1: Global Market for Oncology Drugs by Geography/Country, Through 2020 .

Table 8.2: Top Ten Companies in Oncology Sales, Through 2020 .

Table 8.3: Top Five Oncology Drugs, Through 2020 .

Table 9.1: Global Cancer Immunotherapy Market, Through 2020 .

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Table 9.2: Global Market for Immunotherapy by Product Class, Through 2020 .

Table 9.3: Global Market for Immunotherapy Drugs by Cancer Type, Through 2020 .

Table 9.4: Global Market for Monoclonal Antibodies for Cancer by Type, Through 2020 .

Table 9.5: Global and U.S. Market for Herceptin, Through 2020 .

Table 9.6: Global and U.S. Market for Avastin, Through 2020 .

Table 9.7: Global Market for Cancer Vaccines, Through 2020 .

Table 9.8: Global Market for Cancer Vaccines by Type, Through 2020 .

Table 9.9: Projected Market for the Forthcoming Nivolumab, RG7446, DCVax-L and MEDI4736

.

Table 9.10: Annual Cost of MAbs in the U.S. by Product, Indication and Biomarker .

Table 10.1: Ablynx’s Product Pipeline .

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Table 10.2: Aduro’s Product Pipeline .

Table 10.3: Agenus’ Product Pipeline .

Table 10.4: AlphaVax Cancer Immunology Product Pipeline .

Table 10.5: Amgen’s Product Pipeline .

Table 10.6: Antigen Express’ Cancer Therapeutic Pipeline .

Table 10.7: Argos’ Cancer Product Pipeline .

Table 10.8: Bavarian Nordic’s Product Pipenine .

Table 10.9: Bellicum’s Pipeline Product Candidatea .

Table 10.10: Biogen’s Oncology Pipeline .

Table 10.11: Bristol-Myers Squibb’s Pipeline Products in Cancer Immunotherapy .

Table 10.12: Cellectis’ Products in Development .

Table 10.13: Cellerant’s Product Pipeline .

Table 10.14: Celldex’s Therapeutic Pipeline .

Table 10.15: CEL-SCI’s Immunotherapy Products in Development .

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Table 10.16: EMD Serono’s Product Pipeline .

Table 10.17: Etubic’s Product Pipeline .

Table 10.18: Galena’s Product Pipeline .

Table 10.19: Genentech’s Cancer Immunotherapy Pipel

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