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BIO Industry in JapanBIO Industry in Japan

+Market Size++Market Size+　　 12.5 billion USD 12.5 billion USD

（（ 20012001 ））240.3 billion USD240.3 billion USD

（（ 20102010 ））

2001 2005 2010 2025

Japan 12.5 billion US$

Europe 　 19.2 trillion US$

USA 28.8 trillion US$

Europe 115.3 billion US$Japan 240.3 billion US$

Worldwide 2211.5 billion US$

USA 2884.6 billion US$

2003

Japan 16.3 billion US$

Source: Overview of Biotechnology Strategy Council

Hokkaido the number of bio-ventures

45

Kanto Region the number of bio-

ventures 　

１９４Kansai Region

the number of bio-ventures

7７

　　　　　　　　　　

Source: ‘The number of bio- venture companies in 2003’

by Japan Bioindustry Association

The Bio Clusters in JapanThe Bio Clusters in Japan

Biotechnology Industry in Biotechnology Industry in the the Kansai RegionKansai Region

Key Sectors:

■Pharmaceuticals

■Medical Instruments

■Functional Food

■Pharmas in Kansai are concentrated in Osaka ‘Doshomachi’, the center of Osaka City.

■30% of Japan’s pharmaceutical-related companies and employees are concentrated in Kansai.

■Number of pharmas in Kansai, are equivalent to that of U.K. or France.

■Among the top 18 pharmas for sales in Japan, 8 have their headquarters in Kansai.

Potential for the Potential for the Pharmaceutical Sector in Pharmaceutical Sector in KansaiKansai

The Top 18 Pharmas in The Top 18 Pharmas in JapanJapan

1. Takeda Pharmaceutical 2. Astellas (Yamanouchi + Fujisawa)

3. Sankyo + Daiichi 4. Eisai 5. Shionogi 6. * Chugai Pharmaceutical 7. Taisho Pharmaceutical 8. * Banyu Pharmaceutical 9. Tanabe Seiyaku10. Otsuka Pharmaceutical11. Novartis Pharma12. Kyowa Hakko Kogyo

13. Ono Pharmaceutical14. Mitsubishi Pharma15. Sumitomo Pharmaceuticals16. GlaxoSmithKline17. Dainippon Pharmaceutical18. TAIHO Pharmaceutical

By Amount of sales for drugs:2003By Amount of sales for drugs:2003

■AstraZeneca Japan

■Eli Lilly Japan

■Schering-Plough K.K.

■Bayer Japan

■Boehringer Ingelheim

■Schering

■Organon Japan

■Nihon Medi-Physics

■Proctor & Gamble

Foreign Affiliated Bio-Foreign Affiliated Bio-related companies in related companies in KansaiKansai

Concentration of Bio Research Institutions

■Osaka University (2,100 science researchers)

■Osaka University Hospital and Faculty of Medicine (advanced medical care:1,000beds)

■National Cardiovascular Center (100 researchers, 700beds)

■Osaka City University Medical School■Osaka City University Medical School Hospital■Osaka Bioscience Institute　 (40 researchers)

■Biomolecular Engineering Research Institute (60 researchers)

■Fundamental Technology Research Center for 　　　 Studies on the Creation of New Medicines (more than 50 researchers)

High-leveled Researches 1. Osaka University

2. Kyoto University

3. Okazaki National Research Institutes

4. Kobe University

5. Nagoya University

6. National Institute of Genetics

7. Tokyo University

8. Kyushu University

9. JICHI Medical School

10. Kyoto Prefectural University of Medicine

Distinguished Researchers Distinguished Researchers in Osakain Osaka

＜ Immunology, Oncology ＞ Tadamitsu KISHIMOTO, Osaka University

Toshio HIRANO, Osaka University

Shigekazu NAGATA, Osaka University

＜ Biochemistry Neuroscience ＞ Shigetada NAKANISHI, Kyoto University

＜ Biochemistry ＞ Yasutomi NISHIZUKA, Osaka University

Masashi YANAGISAWA, Texas University (former Kyoto University)

＜ Immunology Molecular Cell ＞ Tetsuya TAGA, Kumamoto University (former Osaka University Professor)

＜ Pharmacology Physiology ＞ Tomoh MASAKI, Tsukuba University (former Kyoto University)

■ 　 Arterial sclerosis

■ 　 Ischemic heart disease

■ 　 High-blood pressure

■ 　 Arthritis rheumatoides

■ 　 Asthma

■ 　 Atopic dermatitis

■ 　 Obesity

■ 　 Diabetes

Focused DiseasesFocused Diseases

Market for the Medical Market for the Medical Instrument SectorInstrument Sector

■Market Size in Japan 20 billion US$ (year 2002)

　⇒　 2nd largest market in the world.

80 billion US$ (year 2010)

Breakdown: ●medical-treatment related equipments 44.7% (PTCA catheter, pacemaker) ●diagnostic device 　　　 31.3% (endoscope, CT, MRI) ●others 　　　 24.0%

Source: Ministry of Health, Labor and Welfare

■Changes in the Population Structure

Aging Society

■Changes in the Disease Structure Acute Disease (infection)

Chronic Disease (cancer, cardiac disorder,

cerebrovascular disease, diabetes)

Trends for Medical CareTrends for Medical Care

■Changes in the quality of medical care examination & treatment prevention of disease

curing technology Quality of Life

Trends in Medical CareTrends in Medical Care

Focused types of medical Focused types of medical instrumentsinstruments

Regeneration related Cardiovascular related

Minimally invasive

treatment

Bio- ImagingAutomotive diagnostic system

Medical examination

■Partnership with overseas companies technical tie-ups

joint research and development

InternationalizationInternationalization

Application for patents for Application for patents for medical instrumentsmedical instruments

0%

10%

20%

30%

40%

50%

60%

70%

Number of applications for patents: 11,537 (year 2000)

USA 64%USA 64%

Europe 27%Europe 27%

Japan 9%Japan 9%

Nipro Corporation

SANYO Electric Biomedical

Toyobo Co., Ltd.

Teijin

Kaneka Corporation

Matsushita Electric Industrial Co., Ltd.

Shimadzu Corporation OMRON Corporation Kyocera Corporation

Companies in KansaiCompanies in Kansai

Market for the Market for the Functional Food SectorFunctional Food Sector

■Market Size in Japan

4.2 billion USD (year 2003)

60 billion USD (year 2010)

Source: Ministry of Economy, Trade and Industry

Potential Market for Potential Market for the the Functional Food SectorFunctional Food Sector

0 1 2 3 4 5 6 7 8 9 10

High blood pressure

Cerebrovascular disease

Ischemic heart disease

Diabetes

Chronic arthritis

Osteoporosis

Gastric and duodenal ulcer

Hepatitis

Asthma

Bronchitis

Cataract

Prostate- gland enlargement

Glomerular disease

Cancer

Alzheimer

Skin Aging

Companies in KansaiCompanies in Kansai

Suntory Limited

Gekkeikan

Glico

Ikari Sauce

Kaneka

OCCI Activities for promotion of Bio-industry■Study Group on Development of Functional Food

■Japan Bio-technology Business Competition

■BIO-Business School

■FORUM for Industrialization of Next Generation Medical Systems, Medical Treatment Systems

■NANO-BIO Industrialization Seminars

■BIO Information Highway Plan-Phase II

■Bio-Delegation to USA (June 20-26, 2005)

Only Business Partnering event for foreign Only Business Partnering event for foreign companies in Japancompanies in Japan

September 12September 12thth and 13 and 13thth

The Simple The Simple ConceptConcept+CONNECT++CONNECT+

Business Partnering Business Partnering ServiceService

GVF Secretariat Pre-Arranges GVF Secretariat Pre-Arranges individual business meetings individual business meetings before the event.before the event.

Search and contact the best Search and contact the best suited suited company -> division -> company -> division -> personnelpersonnel for the presenting for the presenting technology.technology.

Nation-Wide promotionNation-Wide promotion 12. 2 meetings12. 2 meetings per per company company (8.0 pre-arranged) (8.0 pre-arranged)

Who’s in the Audience?Who’s in the Audience?

List of Participants from the past event Asahi Chemical Industry Co.,Ltd. Shimadzu Corporation SUNTORY LTD. Sekisui Chemical Co.,Ltd. KANEKA Corporation Sumitomo Chemical Co.,Ltd. Hitachi Chemical Co.,Ltd. Toyobo Co.,Ltd. Kuraray Co.,Ltd. Nippon Paint Co.,Ltd.

161161 Companies, Companies, 345345 People (2004) People (2004)

Nippon Shokubai Co.,Ltd Takeda Chemical Industri

es,LTD. SHIONOGI & Co.,LTD. Fujisawa Pharmaceutical

Co.,Ltd. Otsuka pharmaceutical C

o.,Ltd.

Result of Individual Result of Individual MeetingsMeetings 7 companies concluded or about

to conclude Contracts. ( Technology tie ups, Joint

Research, Joint Development, Finance, etc)

10 companies continues their business discussions.

0 company had no specific result

Quality FirstQuality First

Only Companies with excellent Only Companies with excellent technology are allowed to technology are allowed to participate after the evaluation participate after the evaluation by Nominating Committee.by Nominating Committee.

Main criteria :Main criteria :

Creativity of Technology and Creativity of Technology and Marketability of Products in Marketability of Products in Japan.Japan.

■Software company from USA made a distribution agreement with a major software distributor in Japan

■Agribio company from Japan, producing UBS Soil Activator received investment from an industrial promotion organization in Japan.

■A bio-tech company from Japan, developing innovative technology to develop oral agents for drugs considered difficult for oral absorption, received investment from an investment firm.

Success Stories from Success Stories from GVF03GVF03

ProcessProcess

Application Deadline Screening Committee Meeting &

Notification to Presenters Audience Recruiting Payment Deadline for Participation Fee Presenter’s Orientation

GVF05-BIO

June June 20th20th

Mid-JulyMid-JulyJuly July 29th29th

May May 20th20th

September September 11th11th

September 12September 12thth--13th13th

Participation FeeParticipation Fee

-Business Match-making Service

-Individual Booth ( W3.0 x L1.5 x H1.5 in meters )

-Simultaneous Interpretation for Presentation

-A Professional Interpreter for business talks for 2days

-Invitation to all GVF related events

-Nation wide promotion

US$1,500-US$1,500-----The Fee Covers----

■Incentives by the Osaka City Government (tentative)

For companies planning to set up a business base in Osaka City, there is a chance to receive refund of the GVF05 Participation Fee from the IBPC Osaka Investment Promotion Center.

■ 1-Day Industrial Trip by METI-Kansai (tentative) The METI-Kansai is planning to hold another industrial trip again for the GVF Participants after the GVF05-BIO event.

Incentives and a 1-Day Incentives and a 1-Day Industrial Trip in KansaiIndustrial Trip in Kansai

How to ApplyHow to Apply Submit necessary documentations to Submit necessary documentations to

appropriate secretariat or coordinator appropriate secretariat or coordinator via E-mailvia E-mail

Template file of Application form can Template file of Application form can be downloaded from the WEB be downloaded from the WEB http://www.gvf.ne.jp/

Attachment of Presentation helpsAttachment of Presentation helps

Thank you very much!!Thank you very much!!

Ryoichi NakanoRyoichi Nakanotel: +81-6-6944-6403tel: +81-6-6944-6403

e-mail: gvf@osaka.cci.or.jpe-mail: gvf@osaka.cci.or.jp

http://www.gvf.or.jp/http://www.gvf.or.jp/ee

For further details and For further details and questionsquestions

Please contactPlease contact