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2006-2007 w w w. d u q . e d u

D u q u e s n e U n i v e r s i t y6 0 0 F o r b e s A v e n u eP i t t s b u r g h , P A 1 5 2 8 2

G R A D U A T E S C H O O L O F

Pharmaceutical Sciences

DIRECTORY

(When on campus, students only need todial the last four digits of these numbers).

Mylan School of PharmacyBayer Learning Center, Room 306Telephone: (412) 396-6380

Graduate School ofPharmaceutical SciencesTelephone: (412) 396-5662

AdmissionsTelephone: (412) 396-1172

CAREER SERVICES CENTERRockwell HallTelephone: (412) 396-6644

CASHIER – Payment of Tuition and FeesGround Floor, Administration BuildingTelephone: (412) 396-6585/6587/6588

COMMUTER AFFAIRS117 Duquesne UnionTelephone: (412) 396-6660

FINANCIAL AIDGround Floor, Administration BuildingTelephone: (412) 396-6607

HEALTH SERVICEDuquesne Towers, Second FloorTelephone: (412) 396-1650

IDENTIFICATION CARDS203 Duquesne UnionTelephone: (412) 396-6191

INFORMATION CENTERFor University ActivitiesDuquesne Union, Third FloorTelephone: (412) 396-6632/6633

OFFICE OF INTERNATIONAL AFFAIRSDuquesne Union, Sixth FloorTelephone: (412) 396-6113

PUBLIC SAFETYPublic Safety BuildingTelephone: (412) 396-6002For Emergency, call (412) 396-4747

REGISTRARAdministration Building, Ground FloorTelephone: (412) 396-6212 – General Office

(412) 396-5623 – Transcripts

RESIDENCE LIFEDirector of Residence Life, Assumption HallTelephone: (412) 396-6655/5028 – Housing Contract

(412) 396-6655/5028 – Room Assignments for Graduate Students

STUDENT ACCOUNTSAdministration Building, Room 208Telephone: (412) 396-6585/6587/6588

UNIVERSITY COUNSELING CENTERAdministration Building, Room 308Telephone: (412) 396-6204/6208

DUQUESNE UNIVERSITYPITTSBURGH, PENNSYLVANIA

Graduate School ofPharmaceutical Sciences

Master of Science andDoctor of PhilosophyDegree Programs

Medicinal ChemistryPharmaceuticsMBA/MS in Industrial PharmacyPharmacology-ToxicologyMS In Pharmacy Administration

2006-2007

RIGHT TO AMENDAs the educational process from admission through graduation requires continuingreview and appropriate approval by University officials, the provisions of this catalogare to be considered directive in character. The University, therefore, reserves theright to change requirements and regulations contained herein, including fees, tuition,and board and room, and to determine whether an individual has satisfactorily metthe requirements for admission or graduation. The material contained herein issubject to change from time to time and this publication cannot be considered anagreement or contract between individual students and the University. TheUniversity reserves the right to alter or amend the terms, conditions, andrequirements herein, and to eliminate programs or courses as necessary.

NOTICE OF NONDISCRIMINATION AND NONHARASSMENT POLICYDuquesne University, motivated by its Catholic identity, values equality ofopportunity, human dignity, racial, cultural and ethnic diversity, both as aneducational institution and as an employer. Accordingly, the Universityprohibits and does not engage in discrimination or harassment on the basis ofrace, color, religion, national origin, sex, age, disability or status as a veteran ordisabled veteran. Further, Duquesne University will continue to take affirmativesteps to support and advance these values consistent with the University’s missionstatement. This policy applies to all educational programs and activities of theUniversity, including, but not limited to, admission, educational policies, scholarshipand loan programs and athletic or other University-sponsored programs. This is acommitment by the University in accordance with its religious values and applicablefederal, state and local laws and regulations. Nothing herein, however, should beinterpreted as a waiver by the University of its own Constitutional and legal rightsbased upon its religious affiliation. The person responsible for coordinating its effortsunder this policy is Dr. Judith Griggs, Affirmative Action Officer, ground floor,Administration Building, university extension 6661.

SECURITY STATISTICS, POLICIES AND PROCEDURESIn accordance with the College and University Security Information Act(Pennsylvania Act 73 of 1988) and the U.S. Student Right to Know and Security Act.(P.C. 101-542), information regarding Duquesne University’s crime statistics,security policies and procedures is available in the Admission’s Office, and dailycrime logs are available for review in the Public Safety Department.

Information contained in this catalog is accurate to the date of publication.Published by Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282.

Graduate School of


Contents

Directory (inside front cover)

Campus Map (inside back cover)

Contents

Preface ........................................................................................................ 1The City ...................................................................................................... 1

The University ............................................................................................ 2

Summary Statement of University Mission and Goals .............................. 3

Summary Statement of School of Pharmacy Vision, Mission and Goals .... 4Academic and Research Resources and Facilities .................................. 4

Application Policies and Procedures ........................................................ 6

Academic Policies and Procedures ........................................................... 8

Master of Science Degree Programs ...................................................... 14

Doctor of Philosophy Degree Programs ................................................ 18

Course Descriptions ................................................................................. 24

Directors and Officers ............................................................................. 32

Administration .......................................................................................... 34

Faculty ...................................................................................................... 34

PrefaceThe Graduate School of Pharmaceutical Sciences was established in 1990

when the faculty in the Pharmaceutical Sciences of the School of Pharmacyrequested and was granted permission to separate from the reorganizedCollege and Graduate School of Arts and Sciences. The Graduate School ofPharmaceutical Sciences offers the Doctor of Philosophy and Master of Sciencedegrees in pharmaceutics, medicinal chemistry, and pharmacology-toxicology,and the Master of Science in Pharmacy Administration. In conjunction with theGraduate School of Business Administration, the Graduate School ofPharmaceutical Sciences offers an M.B.A./M.S. in Industrial Pharmacy.Typically, 70 students are enrolled in graduate programs in the Graduate Schoolof Pharmaceutical Sciences. Most recent M.S. graduates have continued studiesat the doctoral level or are employed in a variety of research laboratory settings.Graduates of Ph.D. programs are employed in research and administrativepositions in industry and in research and teaching in academia.

The CitySurrounded by the Monongahela, Allegheny, and Ohio rivers, the downtown

“Golden Triangle” of the City of Pittsburgh is a corporate headquarters and thehub of numerous cultural activities. This “most livable city in the UnitedStates” supports an internationally renowned symphony orchestra and ballet,opera and numerous dramatic companies. Technology and education flourish inthis city of highly esteemed colleges, universities, and trade and technicalschools. Pittsburgh supports professional teams in football (Steelers), baseball(Pirates) and hockey (Penguins). Perhaps the most engaging quality of thismetropolitan area is the “hometown” flavor of the many individualneighborhoods that comprise the “City of Pittsburgh.”

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The UniversityDuquesne University first opened its doors as the Pittsburgh Catholic

College of the Holy Ghost in October 1878 with an enrollment of 40 studentsand a faculty of seven. From a humble original location on Wylie Avenue inthe City’s Uptown section to its present beautifully self-contained campus,Duquesne provides a hilltop vista overlooking one of the nation’s mostattractive cities.

Today Duquesne University is a progressive educational facility which hasmore than tripled from its early 12.5 acres to its present, self-enclosed 48-acrecampus overlooking the city of Pittsburgh. Tree-lined brick walkways lead toacademic buildings, living-learning centers, research and recreational facilities.

Duquesne’s academics are recognized both nationally and internationally.Almost every state in the Union and more than 75 countries are represented inthe Duquesne family, and our mission of service drives our outreach across thecountry and the globe.

Duquesne’s recent growth has been tremendous with students in tenschools of study, including the College and Graduate School of Liberal Arts(1878); and the Schools of Law (1911); Business Administration (1913);Pharmacy (1925); Music (1926); Education (1929); Nursing (1937); HealthSciences (1990); School of Natural and Environmental Sciences (1994) and theSchool of Leadership and Professional Advancement (2001). Duquesne’s tenschools offer degree programs on the baccalaureate, professional, master’s anddoctoral levels.

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Summary Statement of University Mission and GoalsDuquesne University of the Holy Spirit is a Catholic university, founded by

members of the Spiritan Congregation, and sustained through a partnership oflaity and religious.

The motto of Duquesne University is Spiritus est qui vivificat, “It is theSpirit who gives life.” Enriching the life of the mind and the life of the spirit ofevery member of its community is the mission of Duquesne.

It is Duquesne University’s special trust to seek truth and to disseminateknowledge within a moral and spiritual framework in order to prepare leadersdistinguished not only by their academic and professional expertise but also bytheir ethics, and guided by consciences sensitive to the needs of society.

Therefore, Duquesne is a community of students, faculty, administrators, andothers who are willing to make these commitments:

■ To create undergraduate and graduate education of the highest qualityin liberal and professional disciplines.

■ To examine the moral and ethical foundations of their thought and action,and to develop their personal values and ethical commitment.

■ To participate in an ecumenical dialogue open to all beliefs.■ To extend educational opportunities to those with special financial,

educational, and physical needs.■ To promote world community through the development of an international

and intercultural vision of the global needs and international responsibilitiesfor peace, justice, and freedom.Duquesne serves God by serving students—through an academic commu-

nity dedicated to excellence in liberal and professional education, throughprofound concern for moral and spiritual values, through the maintenance of anecumenical atmosphere open to diversity, and through service to the Church, thecommunity, the nation, and the world.

Complemented by a broad spectrum of nonacademic activities andprograms, the curriculum at Duquesne University is designed to prepare youngmen and women who, upon entering their chosen careers, will possess a broad,well-balanced and fully integrated education and perspective of themselves andthe world.

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Summary Statement of School of Pharmacy and GraduateSchool of Pharmaceutical Sciences Vision, Mission and Goals

The School of Pharmacy is committed to providing excellence inpharmaceutical education.

The mission of the school of Pharmacy is to prepare students for careers inthe profession of pharmacy. Consistent with the University Mission, the valuesthat guide the School are an appreciation for ethical and spiritual values, and asense of personal, professional, and social responsibility.

The goals of the School of Pharmacy are:■ To prepare graduates of the professional program to apply the

pharmaceutical, social, administrative, and clinical sciences todeliver pharmaceutical care in a manner which promotes positivehealth outcomes.

■ To provide programs, services and resources that foster an environment forthe personal and professional growth of students, alumni, practitionersand faculty.

The goals of the Graduate School of Pharmaceutical Sciences are:■ To prepare graduates of the Graduate School of Pharmaceutical Sciences to

serve as pharmaceutical scientists and educators, and making contributionsto the body of scientific knowledge through research and scholarship.

Academic and Research Resources and FacilitiesThe Graduate School of Pharmaceutical Sciences is located in the Richard

King Mellon Hall of Science. Laboratory instrumentation includes nuclear magneticresonance spectrometers, infrared spectrometers, near-infrared spectrometers,ultraviolet-visible spectrophotometers, atomic absorption spectrophotometers, gaschromatographs, high-pressure liquid chromatographs, rheometers, dissolution anddisintegration testing equipment, a benchtop quadrupole GC-mass spectrometerwith electron impact, positive ion and negative ion chemical ionizations, liquidchromatograph with UV diode array detector, gel permeation chromatograph withlaser light scattering, differential pressure viscometry and refractive index detectors,capillary electrophoresis with UV diode array detector, DNA synthesizer, automaticfilm developer, gamma counter, and image analyzer.

Mellon Hall facilities include a fully equipped manufacturing laboratory/pilot plant with slant cone and high shear mixers, a micro fluidizer, fluid bedand spray dryers, coaters, a capsule filling machine, and fully computer

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controlled/ monitored 38-station Hata tablet press. Modern animal facilitiesin adjacent Bayer Hall provide the opportunity for physiological,pharmacological, and toxicological evaluations of drugs and chemicals.Graduate students in the Pharmaceutical Sciences have access to computersin research laboratories and the Pharmacy Computer Center.

The Gumberg Library opened in 1978 and was rededicated in 1995. Thefive-story structure holds an extensive collection which serves the Duquesnecommunity on campus and at a distance, offering access to a collection thatincludes both print and electronic resources. The Library’s collection has grown

to more than 700,000 volumes.The Library makes available more than 190 research databases that index

newspapers, research journals, and other publications. It provides access tomore than 12,000 electronic journals, newspapers, and other periodicals as wellas electronic versions of books, reference works, poems, plays and more.

The Library catalog provides links to many electronic resources and tocatalogs of other regional libraries. Students have several options for obtainingmaterials not available at Gumberg Library including E-ZBorrow and ILLiad.The Library is committed to using evolving technology to deliver the informa-tion that students need in the most cost-effective manner.

The Library participates in local, regional, and state consortia whichsupport reciprocal borrowing. It also maintains agreements with regionalacademic libraries and hospitals that allow students to borrow books onsiteat participating institutions.

Professional librarians are available for on-site and remote consultation andassistance. In addition, the Library designed a course to assist students indeveloping the research and information literacy skills needed to succeed atDuquesne University. The course focuses on basic skills needed by everystudent regardless of major, and examines selected ethical issues surroundingcomputing and using information.

The Library offers computers in the reference area, electronic classroom, andAssistive Technology Center for research needs. The Assistive Technology Centerhas computers equipped for the visually impaired, blind, hearing impaired,learning disabled, and students with limited English.

Wireless access is available throughout the Library. Students can connecttheir personal laptops or loaner laptops anywhere in the Library.

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Within the Gumberg Library, there is the Maureen P. Sullivan CurriculumCenter and other prestigious collections that are recognized locally, regionally,nationally and also internationally. One of these collections, The SimonSilverman Phenomenology Center, promotes the advancement of phenomeno-logy by collecting and making available in one place all the literature onphenomenology and sponsors continuing research and original scholarship. Theother special collections include the Cardinal Wright Collection, the RabbiHerman Hailperin Collection, and the Honorable Michael A. MusmannoCollection. The University Archives is also part of the Library and is the centerfor the documented history of Duquesne University.

In keeping with its mission and by supporting the traditions of academicexcellence and the Spiritan identity of Duquesne University, the GumbergLibrary is the primary locus for distinctive intellectual resources, informationliteracy instruction, and related library services for students. The Library isopen more than 100 hours per week for research and study. However, theelectronic resources are available 24/7 anywhere on campus and remotely.

For more information about the Library’s collections, services, policies,departments, and facilities go to www.library.duq.edu. The website alsoprovides access to the Library’s online catalog, research databases, electronicjournals and texts, and Library newsletter.

Application Policies and ProceduresThe Graduate School of Pharmaceutical Sciences welcomes applications

from individuals who have earned a baccalaureate degree in chemistry, biology,pharmacy, allied health sciences, or social/behavioral or business sciences,depending on the proposed field of study. Students are admitted for the fall orspring semester of the academic year. Applications must be received insufficient time to permit processing and evaluation before enrollment for thepreferred semester. Applications for the fall semester which are received priorto February 1 will be given primary consideration.

Application forms and materials may be obtained from the Director ofGraduate Studies. The completed application and supporting documents (officialtranscripts of all undergraduate and graduate course work, a brief statement ofpurpose and intent with regard to the specific area of graduate study chosen, threeletters of recommendation from persons acquainted with the academic abilities ofthe applicant, and results of the GRE General Test) must be sent to the Director. Allapplicants whose native language or principal language of instruction is not Englishare required to submit their TOEFL scores to the Graduate School. Internationalstudents who are applying for a teaching assistantship are required to submit theirTSE scores to the Graduate School.

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TYPES OF ADMISSIONOn graduate faculty evaluation of an applicant’s credentials for admission

to an M.S. and/or Ph.D. program, students will be admitted as:1. Regular. This is a full and unconditional admission into a graduate

degree program.2. Provisional. Subject to the fulfillment of a specific requirement normally

stated in the letter of acceptance. When the requirement has been fulfilled,the student must submit a request for a change in status, in writing, to theDirector of Graduate Studies.

3. Special Students. A qualified student who does not wish to become adegree candidate may, with the approval of the department or professorconcerned, enroll for a particular course or courses. The student mayreceive official credit for the course. Special Students must be enrolledin another program within the University or submit to the Director ofGraduate Studies a written request to attend graduate classes and evidenceof a Bachelor’s degree from an accredited academic institution. Theapplication fee is five dollars.

4. Temporary Transfer. This is granted to a student in good standing in anyrecognized graduate school who wishes to enroll in the GraduateSchool of Pharmaceutical Sciences of Duquesne University for oneterm or summer session and who plans to return thereafter to his/herformer college or university. The student will not be required to submita full transcript of credits, but must present a statement signed by theGraduate Director of his/ her institution indicating that the student is ingood standing at that institution.

5. Combined Degree Programs. Doctor of Pharmacy students (P III, IV, V)may begin graduate study early with the approval of the Director ofGraduate Studies. Interested students should be referred to the Pharm.D.(with the B.S. in Pharmaceutical Sciences) / M.S. / Ph.D. program policiesand procedures. These students may take only courses numbered 500to 599.

Student Health InsuranceEffective for the 2006 - 2007 academic year, Duquesne University will

require all full time students to have health insurance. This requirementrecognizes the increasing importance of health insurance to every individual.Those who do not otherwise have coverage will be required to purchase apolicy offered by the University at the beginning of the academic year.This requirement, or Hard Waiver, will allow the University to offer ascomprehensive and cost effective plan as possible to all full time students.Those students who demonstrate that they have coverage from any other sourcewill not be required to purchase the University-sponsored plan.

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ASSISTANTSHIPSTeaching and research assistantships, which may include full remission of

tuition and fees, are available to qualified applicants. Assistantships arenormally awarded in the spring for the following academic year.

Eligibility for assistantships is based on academic records, qualificationsand financial need. These assistantships are granted in return for serving in thecapacity of a laboratory teaching assistant and/or research assistant on asemester-to-semester basis. To be eligible for consideration for an assistantship,the student must complete the appropriate section on the official application.

An international student seeking a teaching assistantship is advised thatDuquesne University institutional policy and Pennsylvania state law requiresthat all instructional teaching assistants who are non-native speakers ofEnglish, be certified by the University as meeting acceptable standards ofEnglish language fluency.

Candidates for teaching assistantships are required to submit TSE(Test of Spoken English) scores to the Graduate School of PharmaceuticalSciences. Also, candidates must sit for on-campus language tests conductedfor such certification.

If results of the on-campus language testing for such certification indicatethat the candidate requires assistance with the English language, that candidatewill be responsible for the cost of providing assistance until that individual’slanguage proficiency improves to acceptable standards. Also, testing resultsmay affect the nature and/or limits of the candidate’s assistantship andinstructional duties.

Academic Policies and Procedures

REGISTRATIONPrior Advisement — After a student has been admitted to the Graduate

School of Pharmaceutical Sciences, the student must contact the facultyadvisor within the discipline in which the student will be studying foradvisement as to the exact program requirements. Written approval of thefaculty advisor is required in advance for each registration for any coursecreditable toward a graduate degree.

Official Registration — Registration is considered complete and officialonly when all charges are paid or when satisfactory arrangements have been

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made with the Student Accounts Office of the University. Admission to anyclass is permitted only to those students who have officially registered forthat class.

Continuous Registration — All graduate students who are not registeredfor a course, but who are working toward a degree, must register eachsemester for Continuous Registration and pay the assigned fees. If thestudent is planning to receive a degree in August, the student must registerfor Continuous Registration during the summer session in which the degreecompletion is expected.

Cross Registration — Full-time Duquesne University students maycross-register in the Graduate Schools (Carnegie Mellon University andThe University of Pittsburgh) of the Pittsburgh Council on Higher Education(PCHE) on a space-available basis for one course per semester. Students shouldcheck with their faculty advisor concerning departmental cross-registrationregulations. Duquesne University students who are participating in thisprogram are charged by Duquesne University; however, students areresponsible for paying any special course fees to the host institution. Thereis no cross-registration during the summer sessions.

Cross-registration is subject to the approval of the appropriate officials ofthe institutions involved and must be recommended by the student’s facultyadvisor and approved by the professor in charge of the course. Full credit andthe grade will be posted on the student’s transcript; the academic regulations ofthe host institution will prevail. The cross-registration forms are available fromthe Graduate School Office.

Degree Registration — Graduate students should register for their degreein the semester or summer session in which they expect to complete all of thedegree requirements. If the degree is not completed in the intended semester orsummer session, degree registration is required in the subsequent semesters orsummer sessions until the degree requirements are completed.

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GRADINGThe following grading system is in effect in the

Graduate School of Pharmaceutical Sciences:

A Distinguished scholarly workA-B+B Normal progress toward degreeB-C Warning: Student subject to faculty action!F Failure: Course must be repeated; student subject to

faculty action!I Incomplete: Grade is deferred because of

incomplete work and must be removed within therequired time frame of one academic year.

W Official WithdrawalP Pass: Used in certain courses and is independent of

the quality point system.N Not Passing: Used in courses graded on a Pass/ Fail

basis and is independent of the quality point system.

The above plus and minus grades may be used at the discretion of theinstructor and with notification to students at the beginning of each course.

ACADEMIC STANDARDSAll graduate students must maintain a grade average not lower than B

(3.00 Q.P.A.). Students failing to meet this standard may be subject tofaculty action, including dismissal, for failure to maintain normal progresstoward a degree. Decisions on student academic standing are made by theGraduate School of Pharmaceutical Sciences Council, after an initial reviewand recommendation by the Director of Graduate Studies. Any studenthaving less than 3.00 as a final grade average at the conclusion of coursework will be ineligible for the granting of a graduate degree.

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QUALITY POINT SYSTEMThe student’s overall academic quality point average (Q.P.A.) is

calculated by dividing the total quality points earned by the total numberof semester hours attempted.

Points PerGrade Credits AttemptedA 4.0A- 3.7B+ 3.3B 3.0B- 2.7C 2.0F 0.0

Courses in which grades P, I and W were given are not used incalculating the quality point average.

SEMESTER GRADE REPORTSEvery registered student may access grades through the University

WebAdvisor soon after the close of each semester.

TRANSCRIPTSEach student will receive an unofficial transcript at the close of each

academic year. Students should examine their records carefully foraccuracy and immediately report errors to the Registrar of the Universityand the Director of Graduate Studies.

To obtain additional copies of their academic records, students mustrequest transcripts from the Office of the University Registrar. All officialtranscripts issued by the Office of the Registrar bear the signature of theRegistrar and are printed on secured paper. Whenever an official transcriptis released directly to the student, it will also bear the stamped designation,Issued to Student.

No transcript will be issued unless all financial obligations owed bythe student to the University have been fulfilled. A fee is charged for theissuance of each transcript.

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CONFIDENTIALITY OF STUDENT RECORDSThe University regards the student’s personal information and academic

record as a matter of confidence between the student and the University. Thecontents of either may be revealed only in accordance with the FamilyEducational Rights and Privacy Act of 1974 (Public Law 93-380, Section 438,as amended) and with the Health Insurance Portability and Accountability Actof 1996. A form outlining the policies and procedures of the Graduate School ofPharmaceutical Sciences in observance of the provisions of this law is availablein the Graduate School Office. Each graduate student should complete one ofthese documents upon matriculation to the Graduate School.

AUDITING COURSESTo audit courses, a student must be officially registered and pay the same

charges for courses that are taken for credit. Enrollment in a course for audit issubject to approval of the student’s faculty advisor. Registration in a course asauditor must be declared at registration and is irrevocable after the mid-termexamination period.

CANCELLATION OF COURSESThe University makes every reasonable effort to offer courses as

announced in the Semester Schedule of Courses and Summer SessionBulletin. It reserves the right to make changes or cancel courses in theacademic schedule because of insufficient enrollment or for any otherequally valid reason.

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CHANGE OF SCHEDULEStudents requiring a Change-of-Class Schedule, to add or drop a class, are

permitted to do so during the pre-registration period, the final registrationperiod, and the first class week of the semester (late registration). Change ofclass schedule is not permitted after the last date for change of schedule asannounced in the Semester Academic Calendar.

All schedule changes must be approved by the graduate student’sfaculty advisor and processed with the Graduate School and the Registrar.Schedule change requests processed with the Registrar during the first weekof classes must have the approval of the instructors whose classes are beingadded or dropped.

Students who tardily process change forms are not entitled to a refund forthe course credits dropped. Courses dropped after the deadline for makingschedule changes are classified as course withdrawals.

WITHDRAWAL FROM A COURSEIf a student wishes to withdraw from a course, the student may do so with

the approval of the student‘s faculty advisor and by processing the proper formup to the day prior to final examinations.

If a student wishes to withdraw from a course after that date, the studentmust present valid reasons and seek approval of the student’s faculty advisorand the Director of Graduate Studies. If approval is granted, the student thenobtains and completes the appropriate forms.

A student who is not granted approval of the request and withdraws from thecourse unofficially will receive an F grade for the course.

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Master of Science Degree Programs

PROGRAM REQUIREMENTSCourses — Master of Science degree programs in Medicinal

Chemistry, Pharmaceutics, and Pharmacology/ Toxicology require aminimum of 30 post-baccalaureate semester hours. This includes 24 creditsof course work, including 2 credits of seminar, and an additional 6 creditsof thesis research. The M.S. in Pharmacy Administration, thesis optionrequires 27 credits of course work, including 2 credits of seminar and 9credits of thesis research; non-thesis option, 33 credits of course work,including 2 credits of seminar. Core course requirements are listed for thevarious programs in the Pharmaceutical Sciences. Optional graduatecourses in the Pharmaceutical Sciences or in other disciplines may beacceptable for credit, subject to faculty advisor approval.

In conjunction with the Graduate School of Business Administration, aM.B.A./M.S. in Industrial Pharmacy is offered. This program is an 85-credit (without course work waivers and advanced standing credits), non-thesis program, requiring concurrent graduate-level enrollment in theGraduate School of Business Administration and the Graduate School ofPharmaceutical Sciences. Fifty-seven credits in core graduate BusinessAdministration course work and 28 credits of course work in thePharmaceutical Sciences are required.

A maximum of six credits of graduate course work completed (B orbetter grade) at other accredited academic institutions may be appliedtoward the partial fulfillment of requirements for the Master’s degree. Themajor advisor and the Director of Graduate Studies must approve anytransfer credits applicable toward the M.S. degree.

For all M.S. programs, any deficiencies in undergraduate course workmust be resolved without the granting of graduate credit. Challengeexaminations are not accepted for graduate credit by the Graduate Schoolof Pharmaceutical Sciences. All graduate students are required to maintaingood academic standing, which is defined as a quality point average of 3.0or better.

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Thesis — The student will select a major faculty advisor no later than theend of the second semester of full-time matriculation, and in conjunction withthe advisor, will select a thesis committee. The purpose of the committee is toreview periodically the progress of the research project and to make appropriaterecommendations to the student. The student will submit a thesis proposaldescribing the proposed research to the Director of Graduate Studies, accordingto the guidelines published in the Electronic Thesis and Dissertation Manual.Upon successful completion of the research, the candidate is required toprepare and defend a thesis on the approved topic before the faculty of thediscipline, according to the guidelines set forth in the current Electronic Thesisand Dissertation Manual. Other requirements are outlined in the ElectronicThesis and Dissertation Manual.

RESIDENCYThe candidate must spend at least two consecutive semesters in the

Graduate School of Pharmaceutical Sciences and must take a minimum of 18approved credit hours in residence in the Graduate School of PharmaceuticalSciences. The statue of limitations for the Master of Science degree is fiveyears, M.S. in Pharmacy Administration four years, from the date ofmatriculation in the program. A leave of absence from a degree program mustbe obtained by a student who interrupts the course of study. On request by thestudent, such a leave will be reviewed and a decision rendered by the Directorof Graduate Studies.

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PROGRAM DESCRIPTIONSMedicinal Chemistry — The core curriculum required for the Master ofScience degree in Medicinal Chemistry comprises the following courses:GPHSC 522 Spectral Methods 3 crs.GPHSC 513 Principles of Drug Action,

Design, and Delivery 3 crs.Chem. 501 Biochemistry I 3 crs.Chem. 502 Biochemistry II 3 crs.GPHSC 527 Advanced Medicinal Chemistry 4 crs.Chem. 503 Advanced Organic Chemistry 3 crs.GPHSC 691, 692 Seminar 2 crs.GPHSC 700 Thesis 6 crs.

Additional courses applicable to the M.S. degree program in MedicinalChemistry include the following:GPHSC 528 Heterocycles 3 crs.GPHSC 623 Selected Topics in Medicinal Chemistry 3 crs.

Pharmaceutics — The core curriculum required for the Master of Sciencedegree in Pharmaceutics consists of the following courses:GPHSC 513 Principles of Drug Action,

Design, and Delivery 3 crs.Math 525 OR Applied Statistics 3 crs.Math 555 Biostatistics II 3 crs.GPHSC 501 Manufacturing Pharmacy 4 crs.GPHSC 502 Pharmaceutical Formulation & Development 4 crs.GPHSC 504 Regulatory Aspects of Industrial Practice 2 crs.GPHSC 507 Exploratory Data Analysis 3 crs.GPHSC 510 OR Errors and Assumptions in Pharmacokinetic/

Pharmacodynamic Data Analysis 3 crs.GPHSC 511 Compartmental Modeling of Pharmacokinetic/

Pharmacodynamic Data 3 crs.GPHSC 615 Advanced Pharmaceutics I 3 crs.GPHSC 691, 692 Seminar 2 crs.GPHSC 700 Thesis 6 crs.

A minimum of 3 credits in analytical aspects of pharmaceutics is requiredfor the M.S. degree in Pharmaceutics. Currently GPHSC 521 or 522 maybe selected.

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M.B.A./M.S. In Industrial PharmacyGPHSC 501 Manufacturing Pharmacy 4 crs.GPHSC 502 Pharmaceutical Formulation

& Development 4 crs.GPHSC 504 Regulatory Aspects of Industrial Practice 2 crs.GPHSC 507 Exploratory Data Analysis 3 crs.GPHSC 510 Errors and Assumptions in Pharmacokinetic/


Pharmacodynamic Data 3 crs.GPHSC 522 OR Spectral MethodsGPHSC 521 Analytical Separation Methods 3 crs.GPHSC 615 Advanced Pharmaceutics I 3 crs.GPHSC 616 Advanced Pharmaceutics II 3 crs.

Part B - Graduate School of Business AdministrationCore IA Foundation Skills and Knowledge Courses 20 crs.Core IB Management-specific Knowledge Skills 22 crs.Core II Electives Courses 15 crs.

(Including Regulatory Aspects ofIndustrial Practice 2 credits)

The M.B.A./M.S. in Industrial Pharmacy program is an 85 credit (withoutcourse waivers and advanced standing credits), non-thesis program requiringconcurrent graduate-level enrollment in the Graduate School of BusinessAdministration and the Graduate School of Pharmaceutical Sciences.

Pharmacology-Toxicology — The core curriculum required for the Master ofScience degree in Pharmacology-Toxicology consists of the following courses:GPHSC 513 Principles of Drug Action,

Design, and Delivery 3 crs.Chem. 501 Biochemistry I 3 crs.GPHSC 561 General Toxicology 3 crs.GPHSC 570 Drug Mechanisms 3 crs.GPHSC 572 Methods of Evaluation of Drug Action

and Toxicity 4 crs.GPHSC 672 Advanced Pharmacology I 3 crs.GPHSC 673 Advanced Pharmacology II 3 crs.GPHSC 693, 694 Seminar 2 crs.GPHSC 700 Thesis 6 crs.

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See the Ph.D. in Pharmacology-Toxicology listing for recommended electives.

Pharmacy Administration — The core curriculum for the Master ofScience degree in Pharmacy Administration includes:GPHSC 584 Health Care Economics 3 crs.GPHSC 583 Marketing/ Customer Service 3 crs.GPHSC 586 Managed Care Principles and Policies 2 crs.GPHSC 588 Social and Behavioral Aspects of Pharmacy 3 crs.GPHSC 585 Health Care Financial Management 2 crs.GPHSC 589 Research Methods in Pharmacy Administration 3 crs.GREV 610 Educational Statistics II 3 crs.GPHSC 697, 698 Seminar 1 cr.

Available elective courses are: Pharmacoeconomic Evaluations, Patient-Reported Health Outcomes, Regulatory Aspects of Industrial Practice,and graduate courses in Social and Public Policy, Communication, andBusiness Administration.

Doctor of Philosophy Degree Programs

PROGRAM REQUIREMENTSMatriculation into Doctoral Programs — The disciplines within the

Graduate School of Pharmaceutical Sciences will recommend to the Directorof Graduate Studies and the Dean of the Graduate School, for the matriculationintrodoctoral degree programs, those students who have satisfied requirements.Unless the student has previously earned a Master of Science degree from anapproved program of study, the Ph.D. Qualifying Examination requirementsmust be met before the student can officially matriculate into the Ph.D.programs.

Qualifying for Matriculation into Ph.D. programs — An examination is tobe administered at a time determined by the faculty in the specific discipline,but not before twenty credit hours of approved course work has beencompleted. The intent of this examination is to test the student’s ability to apply

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information, interpret and analyze data, to propose approaches to researchproblems, and general background understanding and knowledge in thearea of the student’s major field of study.

Alternatively, a student may be allowed to matriculate into the Ph.D.programs if (1) the student has earned an acceptable Master of Sciencedegree, or (2) a student, who has taken 20 credit hours and has a minimumQPA of 3.50, petitions a Graduate School review committee to evaluate thestudent’s academic credentials. This committee will consist of the majoradvisor, one or two other faculty members within the discipline of study,and one outside reviewer. Upon review of the student’s credentials, thecommittee will make its recommendation for the student’s matriculationinto the Ph.D. program to the Director of Graduate Studies and the Dean ofthe Graduate School.

Courses — Students pursuing the Ph.D. are required to take aminimum of 60 post-baccalaureate semester hours, including 12 creditsof dissertation research and 48 credits of course work, including core(required) courses, approved electives, and 4 credits of seminar. Eachdiscipline requires the completion of specific Ph.D. core curriculumrequirements. Core course requirements are listed for the variousprograms in the Pharmaceutical Sciences. All advanced standingfor previous course work is at the discretion of the faculty withinthe discipline.

The transfer of graduate course work completed (B or better grade) atother accredited academic institutions, which may be applicable toward thepartial fulfillment of the doctoral degree requirements, is determined byGraduate School review committee action in each individual student case.The awarding of transfer credit for doctoral students must be approved bythe Director of Graduate Studies.

For all Ph.D. programs, any deficiencies in undergraduate course workmust be resolved without the granting of graduate credit. Challengeexaminations are not accepted for graduate credit by the Graduate Schoolof Pharmaceutical Sciences. All graduate students are required to maintaingood academic standing, which is defined as a quality point average of 3.0or better.

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EXAMINATION AND EVALUATIONS FOR THE DOCTOR OFPHILOSOPHY DEGREE

Comprehensive Evaluation — This three-part evaluation is intended toprovide evidence that the student has attained a level of preparednessappropriate to the degree. The comprehensive evaluation process mustbegin after 24 credits of course work have been completed and at leasttwelve months prior to the expected date of graduation. The threecomponents of the comprehensive evaluation process include:a) Comprehensive Examination for Ph.D. Candidacy —

Purpose: The purpose of this examination is to test the student’sscientific approach to problem solving in their area of specialization.The primary intent of this examination is to test the student’s ability toapply information, interpret and analyze data, and propose approachesto research problems. The exam will require general backgroundunderstanding and knowledge in the area of the student’s major fieldof study.Eligibility: After the student has taken a minimum of 24 credits ofgraduate courses toward the Ph.D., and no later than the end of the thirdyear of the Ph.D. program.Offered: The examination will be offered by all disciplines at the sametime during the third week in January and the first week of August.Students who wish to take the exam must complete and submit thecomprehensive examination request form to the Graduate Schoolof Pharmaceutical Sciences not less than two months prior tothe examination.

b) Research Proposal — Each candidate will be required to submit briefsto the faculty, within the specific discipline, on three topics of potentialresearch, but not to include the topic chosen as the dissertation research.The faculty within the specific area will select one of the topicssubmitted to be developed by the student into a complete researchproposal. The student will submit the written research proposal to thefaculty of the specific area of study and will be required to defend theproposal in an oral presentation to faculty of the specific discipline andinvited guests. A copy of the research proposal and the results of thefaculty evaluation of the candidate will be forwarded to the Director ofGraduate Studies. Successful completion of the Research Proposal mustoccur at least twelve months prior to the expected date of graduation.

c) General Evaluation — The candidate’s overall performance willbe evaluated annually by the Director of Graduate Studies based onfaculty evaluations.

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Language Examinations — If required by the discipline, eachcandidate must demonstrate the ability to read technical literature inat least one approved foreign language. No course taken to satisfy thelanguage requirements may be counted toward the credits for thePh.D. Degree.

d) Oral Dissertation Examination — This examination is taken at theend of the doctoral program and essentially represents a defense of thedissertation research.

DISSERTATIONThe student will select a major faculty advisor for the dissertation

research project no later than the second semester of full timematriculation, and in conjunction with the advisor, will select aDissertation Committee. The purpose of the committee is to periodically(at least two meetings per semester) review the progress of the DissertationResearch Project and to make appropriate written recommendations tothe student.

The student will submit an electronic dissertation proposal describing theintended research to the Director of Graduate Studies, according to theguidelines published in the Electronic Thesis and Dissertation Manual.Upon successful completion of the approved research project, thecandidate is required to prepare and defend a dissertation, according to theguidelines in the current Electronic Thesis and Dissertation Manual. Otherrequirements are outlined in the Electronic Thesis and DissertationManual. The defense date for the dissertation should be confirmed onemonth before the defense. The document must be in committee members’possession at least one week prior to the defense.

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RESIDENCYCandidates for the doctoral degree are expected to spend at least one

full year of full-time residency in the Graduate School of PharmaceuticalSciences. In addition, all candidates are required to take a minimum of 24credit hours, 12 dissertation credits, and 4 seminar credits in the GraduateSchool of Pharmaceutical Sciences. Unless a leave of absence from thegraduate program is submitted to the Director of Graduate Studies, andapproved by the Dean of the Graduate School, continuous registration isrequired for each semester and summer session, if applicable, for allmatriculating graduate students. The statute of limitations for the Doctor ofPhilosophy degree programs in the Graduate School of PharmaceuticalSciences is seven years following completion of the Ph.D. candidacyrequirement (comprehensive examination).

PROGRAM DESCRIPTIONSMedicinal Chemistry — The core curriculum required for the Doctorof Philosophy degree in Medicinal Chemistry comprises the followingcourses:GPHSC 513 Principles of Drug Action,

Design, and Delivery 3 crs.GPHSC 522 Spectral Methods 3 crs.Chem. 501 Biochemistry I 3 crs.Chem. 502 Biochemistry II 3 crs.GPHSC 527 Advanced Medicinal Chemistry 4 crs.Chem. 503 Advanced Organic Chemistry 3 crs.GPHSC 623 Selected Topics in

Medicinal Chemistry 3 crs.GPHSC 691, 692 Seminar 4 crs.GPHSC 701 Dissertation 12 crs.

In addition, the Ph.D. candidate will be required to complete 12 crs. ingraduate level courses. Strongly recommended courses are:GPHSC 528 Heterocycles 3 crs.

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Pharmaceutics — The core curriculum required for the Doctor of Philosophydegree in Pharmaceutics consists of the following courses:GPHSC 513 Principles of Drug Action,

Design, and Delivery 3 crs.GPHSC 501 Manufacturing Pharmacy 4 crs.GPHSC 502 Pharmaceutical Formulation

& Development 4 crs.GPHSC 504 Regulatory Aspects of

Industrial Practice 2 crs.GPHSC 507 Exploratory Data Analysis 3 crs.GPHSC 510 Errors and Assumptions in Pharmacokinetic/


Pharmacodynamic Data 3 crs.GPHSC 615 Advanced Pharmaceutics 1 3 crs.GPHSC 616 Advanced Pharmaceutics II 3 crs.GPHSC 691, 692 Seminar 4 crs.GPHSC 701 Dissertation 12 crs.

A minimum of 6 credits in analytical aspects of Pharmaceutics is required forthe Ph.D. degree in Pharmaceutics. Currently, GPHSC 521 and 522 maybe selected.

Basic courses in Mathematics (through Math 215 Calculus III or itsequivalent) and Experimental Design (through Math 555 or its equivalent) arerequired. The following courses are recommended electives:GPHSC 505 Cosmetic Science and Technology 2 crs.GPHSC 506 Cosmetic Science and Technology Lab 1 cr.GPHSC 509 Pharmaceutical Unit

Operations - Solids 3 crs.GPHSC 512 Pharmaceutical Unit

Operations - Liquids 3 crs.GPHSC 518 Fundamentals of Pharmaceutical Solids 3 crs.GPHSC 526 Chemometrics 3 crs.GPHSC 570 Drug Mechanisms 3 crs.Chem. 501 Biochemistry I 3 crs.Chem. 502 Biochemistry II 3 crs.

Other graduate courses in Chemistry may be recommended as electives.

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Pharmacology-Toxicology — The core curriculum required for the Doctorof Philosophy degree in Pharmacology-Toxicology consists of thefollowing courses:GPHSC 513 Principles of Drug Action,

Design, and Delivery 3 crs.Chem. 501 Biochemistry I 3 crs.Chem. 502 Biochemistry II 3 crs.GPHSC 561 General Toxicology 3 crs.GPHSC 566 Clinical Toxicology 3 crs.GPHSC 570 Drug Mechanisms 3 crs.GPHSC 572 Methods of Evaluation of

Drug Action and Toxicity 4 crs.GPHSC 672, 673 Advanced Pharmacology I and II 6 crs.GPHSC 693, 694 Seminar 4 crs.GPHSC 701 Dissertation 12 crs.

With approval, GPHSC 667 or may be substituted for Clinical Toxicology.

The following courses are recommended electives; other electives inMolecular Biology, Biochemistry and Analytical Chemistry may also beappropriate.GPHSC 574 Neuronal Biochemistry 2 crs.GPHSC 667 Forensic Toxicology 3 crs.GPHSC 507 Exploratory Data Analysis 3 crs.GPHSC 521 Analytical Separation Methods 3 crs.

Course Descriptions501. Manufacturing Pharmacy. 4 crs. A comprehensive courseaddressing the techniques and equipment utilized in the large scaleprocessing of solids. Lectures and laboratory experience is provided in theprocessing of solids (such as tablets and hard gelatin capsules). Specialemphasis is placed on methods of quality control, tablet tooling andmanufacture and characterization, fluid-bed precessing, and sterileprocessing of parenteral medication. Student presentations on currenttopics of good manufacturing practices and current industry emphases arerequired. Lecture, two hours; laboratory, eight hours.

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502. Pharmaceutical Formulation and Development. 4 crs. A coursedesigned to introduce and apply the principles of formulation anddevelopment of pharmaceutical products. Emphasis is on prolonged orcontrolled release of drugs. Independent student research projects are usedto evaluate student research management and problem solving skills.Student presentations on current topics of drug delivery and formulationand development are required. Lecture, two hours; laboratory, eight hours.

504. Regulatory Aspects of Industrial Practice. 2 crs. The principal fociof this course are the Federal government’s regulation of thepharmaceutical and biotechnology industries research and development,manufacturing, approval, and marketing of drugs and drug products and, toa lesser extent, diagnostic agents and devices, cosmetic, and foods; theconcept of intellectual property (i.e., patents, trade secrets, etc.) and its rolein the pharmaceutical and related industries. Lecture, two hours.

505. Cosmetic Science and Technology. 2 crs. An overview of cosmeticproducts embracing their rationale, historical development anddermatologic aspects. Stress is placed on product formulation althoughmethods of product evaluation are discussed as well. Lecture, two hours.

506. Cosmetic Science and Technology Laboratory. 1 cr. The focusof the laboratory is on the formulation and bench-scale preparation ofcosmetic and dermatologic products using a wide range of adjuvantsunique to the cosmetic industry. Product categories include makeup, eyeshadow, mascara, and lipstick, as well as preparations for the skin and hair.Laboratory, four hours.

507. Exploratory Data Analysis. 3 crs. The course addresses in depthexploratory data analysis as a prelude to mathematical modeling withemphasis on data transformation and graphical or data visualizationmethodologies. Lecture, three hours

509. Pharmaceutical Unit Operations — Solids. 3 crs. A course designedto introduce the principles and concepts of pharmaceutical unit operationsof solid dosage forms using a thermodynamic approach. Lecture materialswill be supplemented by visual interactive computer simulations ofpharmaceutical unit operations, guest lecturers from the pharmaceuticalindustry, and visits to pharmaceutical companies. Lecture-computer lab,three hours.

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510. Errors and Assumptions in Pharmacokinetic/PharmacodynamicData Analysis. 3 crs. The fundamental concepts and assumptions thatunderpin biopharmaceutics and pharmacokinetics are explored in depth inthis course and examined in terms of the errors that can be incurred whenthese concepts and assumptions are invalidated, inapplicable, or limited intheir relevance. Lecture, three hours.

511. Compartmental Modeling of Pharmacokinetic/PharmacodynamicData. 3 crs. This course encompasses the mathematical models that havebeen used to characterize systemic drug concentrations and effects as afunction of time, along with the models’ corresponding biopharmaceuticand pharmacokinetic assumptions. The latter assumptions include theinfluence of drug dose, formulation, route of administration, andpatient/volunteer characteristics on the model and its parameters.Lecture, three hours.

512. Pharmaceutical Unit Operations — Liquids. 3 crs. This courseaddresses unit operation principles in the manufacturing of liquids andsemisolids. Emphasis is given to formulation parameters such as process,equipment, rheology, materials/excipients, and scale up. Course lectureswill be supplemented by guest lecturers from the pharmaceutical industryand special projects. Lecture, three hours.

513. Principals of Drug Action, Design, and Delivery. 3 crs. This courseaddresses the basic theoretical background essential to the drug design anddevelopment processes and describes the interrelationships among thedisciplines of the Pharmaceutical Sciences. Lecture, three hours

518. Fundamentals of Pharmaceutical Solids. 3 crs. The purpose of thiscourse is to foster basic understanding of the solid state and relevantanalytical techniques for its characterization. Theory will begin byaddressing atomic solids, with an eventual emphasis on small molecularorganic materials. Topics within this course include solidification,nucleation and growth, surface properties, diffusion processes andsolid state reactions/reactivity, crystalline polymorphism, the amorphoussolid state, deformation processes, and mechanical properties ofconsolidated bodies. Lecture, three hours.

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521. Analytical Separation Methods. 3 crs. A course concerned with basictheoretical principles and their application to chemical and pharmaceuticalsystems of chromatographic methods of analysis. Discussion is focused onthe use of the various instruments according to the students’ past experienceand pharmaceutical discipline. Lecture, three hours.

522. Spectral Methods. 3 crs. A course designed to introduce students tothe molecules given the ultraviolet, infrared, nuclear magnetic resonanceand mass spectra data. Demonstration and laboratory practice of ultraviolet,infrared and nuclear magnetic resonance spectrometry application isincluded. Lecture, three hours; laboratory, one hour.

526. Chemometrics. 3 crs. A course which introduces commonchemometric routines used for evaluation of multivariate data and theapplication of these methods in the solution of practical chemical andspectroscopic problems arising from actual laboratory results. Lecture-computer lab, three hours.

527. Advanced Medicinal Chemistry. 4 crs. This course applies theconcepts covered in Principles of Drug Action, Design, and Delivery toissues concerning drug solubility, drug-receptor interactions,stereochemical aspects of drug action, and basic concepts in molecularmodification (homolagation, fragmentation, molecular hybridization,isosteric substitutions). Advanced concepts discussed include: receptorinteractioins, QSAR, approaches to the rational design of enzymeinhibitors, the relationship of drug metabolism to drug design, the design ofprodrugs, the design, execution and analysis of combinational libraries.Recent advances in specific areas relating to molecular modeling as appliedto the design of drugs, direct and indirect computer-aided ligand design, thepharmacophore concept and its use, the receptor-excluded and receptor-essential volumes, solvation effects, and examples of 3D-pharmacophoresand their use, will be presented. Lecture, four hours.

528. Heterocycles. 3 crs. This course presents the physical, chemical, andmedicinal chemical aspects of aromatic heterocyclic compounds, based ona prior understanding of modern structure identification techniques and ofmechanistic organic chemistry. An emphasis will be placed onnomenclature, organic chemistry, and relevance to drug action. Lecture,three hours.

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561. General Toxicology. 3 crs. A lecture and laboratory demonstration coursedealing with the multidisciplinary aspects of toxicology with emphasis on thebiological test methods for toxic substances and the general clinical andanalytical procedures used by the toxicologist. Food and Drug Administrationregulations and suggested tests are also considered. Lecture, three hours.Alternate years.

566. Clinical Toxicology. 3 crs. A course which outlines the basic principles ofmanagement of the poisoned patient. Emphasis is placed on the underlyingmechanism of toxicity, toxicological changes, clinical manifestations, relatedlaboratory tests and treatment of drugs and chemical toxicity. Prerequisites:Pharmacology or permission of the instructor. Lecture, three hours.

570. Drug Mechanisms. 3 crs. A course designed to introduce the molecularand biochemical basis of pharmacologic selectivity and drug actions. Theseprinciples will be discussed in areas such as receptor theory, receptor regulationand signal transduction, and receptor classification. Lecture, three hours.Alternate years.

572. Methods of Evaluation of Drug Action and Toxicity. 4 crs. A lecture-laboratory course, which encompasses the use of physiological and analyticalmethods, used in determining the site, mechanism of action, and toxicity ofdrugs and chemicals. The sequence of laboratory experiments involves aninterdisciplinary approach incorporating the various areas of pharmacology andtoxicology. This includes basic techniques used to monitor drug action andtoxicity, in vitro biochemical methods used to determine pharmacologic andtoxicologic actions, teratogenicity and reproductive toxicity. The analyticaltechniques include spectrophotometry, gas-liquid chromatography, GC-massspectrometry, high-pressure liquid chromatography, atomic absorptionspectrometry, immunoassays, gel electrophoresis, and tissue cell techniques.Lecture, two hours; laboratory, four hours. Alternate years.

574. Neuronal Biochemistry. 2 crs. A course designed to examine the cellularand biochemical foundations of neuronal function. Emphasis is given toexperimental paradigms of the membrane actions of drugs, transmitters,modulators, and trophic factors on neuronal biochemistry, anatomy andphysiology. The study of neuronal signaling, receptor classification andinteraction, second messenger function and metabolism will provide anunderstanding and appreciation for neuronal function at the cellular and sub-cellular level. Lecture, two hours.

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583. Marketing and Customer Service. 3 crs. The course recognizes the uniquedifferences, which arise from the intangible nature of services, in marketing andmanaging service operations. While general service operations will be considered,the primary focus will be on pharmacy and health related organizations. Theperspective is marketing and managing services for a competitive marketingadvantage. Lecture-discussion, three hours.

584. Health Care Economics. 3 crs. The course is designed to foster anunderstanding of the economic principles that drive the demand for and supplyof health care in the United States. Course content will focus on the logicbehind the decisions made by the physicians, hospitals, managed careorganizations, and government and the choices made by consumers onindividual and aggregate levels. Emphasis will be on economic theory, with theapplications of the theory to real situations that have occurred and/or arepredicted to occur. Lecture-discussion, three hours.

585. Health Care Financial Management. 2 crs. The course is designed tofoster understanding of financial management and accounting principles asapplied to pharmacy and health care. Financial concepts presented includefinancial statements, ratio analysis, cost of money, budgeting, the pricing ofservices, differential analysis, capital investment decisions, cost managementand trends, business plan development for health care services, taxation, andcash flow. The topics covered will enhance the financial decision makingabilities of health care practitioners. Lecture-discussion, two hours.

586. Managed Care Principles and Policies. 2 crs. The course presents anoverview of the impact of managed care on the administration and delivery ofhealth care services and pharmaceutical care. Course topics include Federallegislation, designing prescription drug benefits, medical policy and technologyassessment and patient care management. Lectures will be delivered bypractitioners who work in managed care organizations or consulting practices.Lecture-discussion, two hours.

587. Pharmacoeconomics. 2 crs. The purpose of the course is to supportstudents’ development of competence in population-based, health care decision-making using an integrated assessment of economic, clinical, and humanisticoutcomes. Students will learn through didactic lecture, critical analysis ofapplicable pharmacoeconomic literature, and the presentation of a group projectthat addresses a pertinent and contemporary pharmacoeconomic issue. Lecture-discussion, two hours.

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588. Social and Behavioral Aspects of Pharmacy. 3 crs. The focus will be onconfronting issues, recognizing potential threats, and resolving problems facingpractitioners’ practices at individual and professional levels. The courseemphasizes current administrative topics in pharmacy management from abehavioral perspective. Various current and accepted models will be used toexplain and predict behaviors of pharmacists, other health care practitioners,insurers, and consumers of drugs and pharmacy services. Lecture-discussion,three hours.

589. Research Methods in Pharmacy Administration. 3 crs. The courseexamines the issues and problems associated with research and seeks to developresearch guidelines using the methods, design, and statistical analysis common tosocial and behavioral research. The preparation and defense of a thoroughresearch proposal/project is a requirement for completion of the course. Lecture-discussion, three hours.

590. Pharmacoeconomic Evaluations. 3 crs. This course provides an overviewof the role of economic evaluation in health care with a special emphasis onpharmacy-related issues. Specific areas covered include the need for economicevaluations, different types of economic analyses, sources of data, quality-of-lifevaluations, assessment of utility, and current approaches to pharmacoeconomicsand outcomes research. Lecture, readings, participatory discussions, and studentpresentations, three hours.

591. Patient-Reported Health Outcomes. 3 crs. This course presents an over-view of health outcomes research as reported in Patient-Reported Outcome(PROs) studies which evaluate the impact of disease, medical care and treatmentfrom the patient’s perspective. The focus is on PROs which measure quality oflife, self-reported health status, patient satisfaction, health state preferences, andadherence to therapy. Principles of measurement, reliability, validity, responsive-ness, analysis and interpretation will be discussed using examples drawn fromspecific quality-of-life instruments and their applications. An appreciation of themeasurement and evaluation of PROs and their importance in new drug applica-tions and in drug labeling and advertising is stressed. Lecture, readings, participa-tory discussion, and presentations, three hours.

615. Advanced Pharmaceutics I. 3 crs. Topics of current interest in pharmaceu-tics are presented in depth. Currently, these include chemical and physicalstability evaluation of pharmaceutical formulations and the theory and predictionof solubility. Lecture, three hours.

616. Advanced Pharmaceutics II. 3 crs. Topics of current interest inpharmaceutics are presented in depth. These include mass transport phenomena,with emphasis on diffusion in continual and multiphase system, physical andphysiochemical test methods for drugs and drug delivery systems. Lecture,three hours.

623. Selected Topics in Medicinal Chemistry. 3 crs. Topics of currentinterest in the field of Medicinal Chemistry will be presented. The choiceof subjects will vary from year to year, but may include such topics as CNScompounds, antitumor agents, cancer chemotherapy, carcinogenesis andcarcinogenic compounds, mechanism of bio-organic reactions, drug designand modern theories of drug action. Lecture, three hours.

666. Special Projects in Toxicology. 3 crs. A special, minor researchproblem is assigned involving specialized equipment or a subject of currentinterest. A lecture or discussion period is provided each week during thecourse. Lecture, one hour; laboratory, eight hours.

667. Forensic Toxicology. 3 crs. The drugs and chemicals of forensicinterest are described in a “case presentation” format. Tissue distribution,metabolic fate and excretion of forensically important chemicals and theanalytical methods for their determination are presented. The medico-legalimplications of each group of toxicants are discussed. Lecture, three hours.Alternate years.

668. Special Problems in Pharmacology. 3 crs. A minor research problemis assigned, involving specialized equipment or a subject of current interestrelated to Pharmacology or Pharmacotherapy. Lecture, one hour;laboratory, eight hours.

672, 673. Advanced Pharmacology I and II. 6 crs. A course designed topresent the student with a basic research-oriented understanding of themechanism involved in the areas of autonomic cardiovascular, endocrine,and central nervous system pharmacology. This is accomplished bystudent-driven presentation and discussion of the topics assigned withineach major area. Lecture, three hours each course.

689. Independent Study and Research. 1-3 crs. Independent Study andResearch is structured to provide the student with an opportunity to pursuea meaningful academic experience beyond the required course work andspecific thesis/ dissertation research of the graduate degree program. Thecourse requires that the student demonstrate the capacity to analyze, judge,and discriminate in the solution of a scientific problem.

691, 692; 693, 694; 697, 698. Seminar. 1 cr. each. Oral presentationby graduate students, faculty, and invited speakers on topics of currentresearch. Participation is required of all graduate students during eachsemester of matriculation.

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32

Directors and Officers*

THE MEMBERSHIP OF THE DUQUESNE UNIVERSITY CORPORATIONVery Rev. Jeffrey T. Duaime, C.S.Sp. .................................................................................. ChairRev. Timothy J. Hickey, C.S.Sp. .................................................................................. Vice ChairRev. John A. Sawicki, C.S.Sp. ....................................................................... Secretary/TreasurerRev. Christopher H. McDermott, C.S.Sp.Rev. John P. Skaj, C.S.Sp.Rev. Freddy J. Washington, C.S.Sp.

BOARD OF DIRECTORSOfficersJohn J. Connelly ............................................................................................. Chair of the BoardP. David Pappert ......................................................................................Vice Chair of the BoardMarie Milie Jones .................................................................................... Vice Chair of the BoardLinda S. Drago ............................................................................................. University Secretary

TERM MEMBERSGregory S. BabeJohn J. ConnellyJames N. CrutchfieldSr. Mary Dacey, S.S.J.Thomas R. DonahueRobert Z. GussinJoseph C. GuyauxRev. Francis X. Hanley, C.S.Sp.Marie Milie JonesSamuel P. KaminRev. Sean P. Kealy, C.S.Sp.William J. LyonsGlenn R. MahoneEdward G. O’ConnorJames F. O’DayP. David PappertPatricia D. Yoder

EX-OFFICIO MEMBERSMost Rev. Paul BradleyCharles J. Dougherty, Ph.D.Very Rev. Jeffrey T. Duaime, C.S.Sp.Rev. Timothy J. Hickey, C.S.Sp.Shelley L. KobuckRev. John A. Sawicki, C.S.Sp.

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EMERITI MEMBERSCynthia A. BaldwinAnthony L. BucciJohn E. ConnellyJoseph W. DeNardoJohn F. DonahueFloyd R. GanassiCharles D. HorneDaniel R. LacknerMaurice V. PeconiJohn G. RangosArthur J. Rooney IIWilliam C. SpringerJohn A. Staley IVAlbert C. Van DusenSr. Linda Yankoski, CSFN

OFFICERS OF THE UNIVERSITYCharles J. Dougherty, Ph.D. ....................................................................................... PresidentRalph L. Pearson, Ph.D. ............................... Provost and Vice President for Academic AffairsStephen A. Schillo, M.S. ................................... Vice President for Management and BusinessRev. Sean Hogan, C.S.Sp. ........................................ Executive Vice President for Student LifeLinda S. Drago, J.D. ..................................................... General Counsel/University Secretary

*This information has been provided by the Office of the University Secretary.

ADMINISTRATIONJ. DOUGLAS BRICKER, Ph.D., DeanMylan School of Pharmacy and the Graduate School ofPharmaceutical Sciences

DAVID A. JOHNSON, Ph.D., Director of Graduate StudiesGraduate School of Pharmaceutical Sciences

THE FACULTY AND THEIR RESEARCH

MEDICINAL CHEMISTRY

ALEEM GANGJEE, Professor of Medicinal Chemistry; Mylan School ofPharmacy Distinguished Professor; Ph.D., Iowa. Synthetic medicinalchemistry, computer-assisted drug design, inhibitors of folate metabolizingenzymes, receptor tyrosine kinase inhibitors, antimitotic agents, antitumoragents, antiopportunistic infection agents, heterocyclic chemistry andstereochemistry.

PATRICK FLAHERTY, Assistant Professor of Medicinal Chemistry; Ph.D.,Iowa. Synthetic medicinal chemistry and rational drug design, emphasis onemerging biochemical targets relevant to human disease states, modernsynthetic methodology, and iterative rounds of computation, synthesis, thenbiochemical analysis; general therapeutic areas of interest—CNS agents(CDK5 and alpha-synuclein) and anti-cancer agents.

MARC W. HARROLD, Professor of Medicinal Chemistry; Ph.D., Ohio State.Development of computer-based educational tools, instructional strategies inmedicinal chemistry, drug design.

PHARMACEUTICS

MOJI CHRISTIANAH ADEYEYE, Professor of Pharmaceutics; Ph.D.,Georgia. Preformulation, development, stability and bioavailability evaluationof immediate and sustained release liquid, semi-solid, and solid dosage forms;excipient characterization; biopharmaceutical product technology; unitprocess optimization; anti-retroviral pediatric dosage forms.

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CARL A. ANDERSON, Assistant Professor of Pharmaceutical Sciences;Ph.D., Texas (Austin). Sensor technology for the study and control ofpharmaceutical manufacturing, employing technologies such as acoustic andnear-infrared spectroscopy processed by chemometric methods.

LAWRENCE H. BLOCK, Professor of Pharmaceutics; Ph.D., Maryland.Theoretical aspects of pharmacokinetics and pharmacodynamics; controlledand modified release drug and cosmetic delivery system development;excipient characterization; pharmaceutic aspects of chitin, chitosan, andchitinosans; pharmaceutical engineering, especially scale-up of processingof non-parenteral liquids and semi-solids; and hydrophilic gels as drugdelivery systems.

JAMES K. DRENNEN III, Associate Professor of Pharmaceutics; Ph.D.,Kentucky. Pharmaceutical and medical applications of near-infraredspectroscopy, process control, chemometrics, process analytical technology.

PETER WILDFONG, Assistant Professor of Pharmaceutics; Ph.D., Purdue.Pharmaceutical materials science, with current research projects exploring howspecific physico-chemical and structural properties of pharmaceutically relevantmaterials impact large-scale manufacturing and final dosage form performance;emphasis on mechanically activated solid state phase transformations of APIsand excipients; investigating the potential of high-shear induction ofpolymorphism and amorphization.

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PHARMACOLOGY TOXICOLOGY

J. DOUGLAS BRICKER, Associate Professor of Pharmacology-Toxicology;Ph.D., Duquesne. Effects of drugs, chemicals, and disease states on the regula-tion of calcium uptake mechanisms, development and screening of antidotalagents for clinical use, in vitro toxicity testing methods.

VICKI L. DAVIS, Assistant Professor of Pharmacology; Ph.D., North Carolina.Effects of pharmaceutical, environmental, plant and natural estrogens exposureon the development of breast cancer and cataracts in women, with emphasison using various techniques to determine potential methods of decreasing therisk factors.

DAVID A. JOHNSON, Associate Professor of Pharmacology-Toxicology;Ph.D., Massachusetts College of Pharmacy and Allied Health Sciences. Drugswhich enhance the function of neuronal pathways involved with learning andmemory, neuropathology and the treatment of eating disorders.

WILSON S. MENG, Assistant Professor of Pharmaceutical Sciences(Pharmacology-Toxicology and Pharmaceutics); Ph.D., Southern California.Structure-based design of tumor reactive T-cell epitopes and development ofparticle-based DNA delivery systems.

CHRISTOPHER K. SURRATT, Associate Professor of Pharmacology; Ph.D.,Virginia. Structure-function studies on brain receptors that recognizepsychostimulant and opiate drugs of abuse.

PAULA A. WITT-ENDERBY, Associate Professor of Pharmacology-Toxicol-ogy; Ph.D., Arizona. Molecular pharmacology of melatonin receptors and itsassociated signaling cascades, with emphasis on the role of melatonin in stemcell differentiation.

PHARMACEUTICAL ADMINISTRATION

SHANE P. DESSELLE, Associate Professor of Pharmaceutical Administration;Ph.D., Louisiana-Monroe. Financial, economic, and human resources manage-ment of community pharmacies, prescription drug benefit design issues,direct-to-consumer prescription drug advertising, Web-based pharmacyservices, pharmacy education issues.

VINCENT J. GIANNETTI, Professor of Pharmaceutical Administration; Ph.D.,Pittsburgh. Prescription drug adherence, mental health, substance abuse,pharmacist counseling behaviors, health care policy and ethics, coping withmedication errors.

KHALID M. KAMAL, Assistant Professor of Pharmaceutical Administration;Ph.D., West Virginia. Application of decision and cost-effectiveness analysisin health policy and medicine; heath outcomes assessment in chronicconditions as rheumatoid arthritis, ankylosing spondylitis, chronic obstructivepulmonary disease.

DAVID J. TIPTON, Associate Professor of Pharmaceutical Administration;Ph.D., St. Louis. Medication errors, services marketing, emotional intelligence.

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60

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15282

Date post:	22-Feb-2016
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