Graduiertenkolleg 2162/1:“Neurodevelopment and CNS Vulnerability”
Scientific Background
Einrichtungsbegutachtung 3. Juni 2015 2(Courtesy of F.H. Gage)
MalformationsIntellectual DisabilityAutism Spectrum Disorders
MalformationsIntellectual DisabilityAutism Spectrum Disorders
CNS DevelopmentCNS Development
Scientific Background
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Scientific Background
MalformationsIntellectual DisabilityAutism Spectrum Disorders
MalformationsIntellectual DisabilityAutism Spectrum Disorders
CNS DevelopmentCNS Development
Adult neuropsychiatric /-degenerative diseasesAdult neuropsychiatric /-degenerative diseases
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Novel Concept: Developmental Impact onadult-onset CNS Diseases
MalformationsIntellectual DisabilityAutism Spectrum Disorders
MalformationsIntellectual DisabilityAutism Spectrum Disorders
CNS DevelopmentCNS Development
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Adult neuropsychiatric /‐degenerative diseasesAdult neuropsychiatric /‐degenerative diseases
Novel Concept: Developmental Impact onadult-onset CNS Diseases
MalformationsIntellectual DisabilityAutism Spectrum Disorders
MalformationsIntellectual DisabilityAutism Spectrum Disorders
CNS DevelopmentCNS Development
Disease SusceptibilityDisease Susceptibility
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MalformationsIntellectual DisabilityAutism Spectrum Disorders
MalformationsIntellectual DisabilityAutism Spectrum Disorders
CNS DevelopmentCNS Development
Disease SusceptibilityDisease Susceptibility
Adult neuropsychiatric /-degenerative diseasesAdult neuropsychiatric /-degenerative diseases
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Novel Concept: Developmental Impact onadult-onset CNS Diseases
Rethinking pathogenesis of adult-onset diseases:Common genetics and pathways with developmental disorders
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Adult-onsetCNS diseases
Developmental disorders
Genes &Pathways
Rethinking pathogenesis of adult-onset diseases:Common genetics and pathways w/ developmental disorders
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(Endele, ... Reis, et al., Nat. Genet. 2010)
(Gregor, ... Reis,...Zweier; BMC Medical Genetics, 2011)
(Zweier..., Reis, et al., AJHG, 2007)
TCF4
CNTNAP2
GRIN2B
Rethinking pathogenesis of adult onset diseases:Developmental genes as risk factors
(Stolt...and Wegner, Development, 2004)
(Sawcer et al., Nature, 2011)
(Lill et al., Brain, 2013)
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MalformationsIntellectual DisabilityAutism Spectrum Disorders
MalformationsIntellectual DisabilityAutism Spectrum Disorders
CNS DevelopmentCNS Development
Disease SusceptibilityDisease Susceptibility
Adult neuropsychiatric /-degenerative diseasesAdult neuropsychiatric /-degenerative diseases
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Aim of the RTG
Faculty
Faculty of SciencesHelmut Brandstätter Department of BiologyHanna Regus-Leidig Department of BiologyKristina Friedland Department of Chemistry and Pharmacy
Faculty of Medicine (Basic Sciences)Christian Alzheimer Institute of PhysiologyChichung Lie Institute of BiochemistryMichael Wegner Institute of Biochemistry
Faculty of Medicine (Clinics)Johannes Kornhuber Clinic for PsychiatryRalf Linker Clinic for NeurologyAndré Reis Institute of Human GeneticsJürgen Winkler Division of Molecular NeurologyBeate Winner IZKF Junior GroupChristiane Zweier Institute of Human Genetics
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Junior Faculty
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Faculty of SciencesHelmut Brandstätter Department of BiologyHanna Regus-Leidig Department of BiologyKristina Friedland Department of Chemistry and Pharmacy
Faculty of Medicine (Basic Sciences)Christian Alzheimer Institute of PhysiologyChichung Lie Institute of BiochemistryMichael Wegner Institute of Biochemistry
Faculty of Medicine (Clinics)Johannes Kornhuber Clinic for PsychiatryRalf Linker Clinic for NeurologyAndré Reis Institute of Human GeneticsJürgen Winkler Division of Molecular NeurologyBeate Winner IZKF Junior GroupChristiane Zweier Institute of Human Genetics
Interdisciplinarity of the RTGExpertise in
• Psychiatry and Neurology• Human Genetics• Molecular Biology• Cell & Developmental Biology• Biochemistry• Neurophysiology• Behavioral Neurobiology• Genomics• Disease models• Pharmacology
Qualification program Research projects Supervision
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Interdisciplinarity of the RTG
Cell Biological Processes
Cell Biological Processes
Neural CircuitsNeural Circuits
Disease modelsDisease models
Experimental Therapies
Experimental Therapies
Clinical Neurobiology &
Human Genetics
Clinical Neurobiology &
Human Genetics
MolecularPathwaysMolecularPathways
Expertise in
• Psychiatry and Neurology• Human Genetics• Molecular Biology• Cell & Developmental Biology• Biochemistry• Neurophysiology• Behavioral Neurobiology• Genomics• Disease models• Pharmacology
Qualification program Research projects Supervision
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RTG Research Areas:
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Alzheimer, Friedland, Kornhuber(ASM-Pathway in development & neuropsychiatric disease)
Winkler, Winner(Neurodegenerative disease genesin development)
Linker, Wegner(Developmental Genes in Dys- and Demyelination)
Lie, Reis, Zweier, Postdoctoral Project(Common pathways intellectual disability & neuropsychiatric disease)
Brandstätter, Regus-Leidig(Synapse and neurodegeneration)
Promoting Clinician-Scientist Careers:
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MD StudentExperimental
Thesis
ResidentDevelopment of Scientific Expertise
Clinician-Scientist
Independent Research
Clinician-Scientists are important cornerstones for• Communication between basic and clinical research• Development of new treatment strategies
CL4
Folie 17
CL4 Quality assurance könnte man weglassen, da wir hier nicht darauf eingehen? Hier der Link für das DFG Statementhttp://www.dfg.de/download/pdf/dfg_im_profil/reden_stellungnahmen/2015/empfehlungen_clinician_scientists_0415.pdfChichung Lie; 22.05.2015
MD StudentExperimental
Thesis
ResidentTranslational
Expertise
Clinician-Scientist
Independent Research
Promoting Clinician-Scientist Careers:
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Clinician-Scientist in the RTG:
● 6 clinician-scientist principal investigators (50%)
● 1 associated clinician-scientist ● 2 MD rotation positions
● 13 MD thesis fellowships
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Clinical Neuroscientists
Clinical Neuroscientists
Basic Neuroscientists
Basic Neuroscientists
Promoting Clinician-Scientist Careers:
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MD StudentExperimental
Thesis
ResidentDevelopment of Scientific Expertise
Clinician-Scientist
Independent Research
Recruitment: RTG meets MD student seminar Lab internships Doctoral fellowships
Promoting Clinician-Scientist Careers:
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MD StudentExperimental
Thesis
ResidentDevelopment of Scientific Expertise
Clinician-Scientist
Independent Research
Clinician-scientist fellowships Research infrastructure Mentoring Training Methods and Soft-Skills
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Mandatory
• Lectures• Colloquium / Retreat / Conference
Facultative
• Neuroscience Lecture• Career Options and Excursions• Method Courses• Soft Skill Courses
Methods, Theory, Concepts in Neuroscience
Qualification Program
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Daten
GRK Start 1. Juli 2016
Rekrutierung 1. Kohorte MD Studenten Spätsommer 2016 (2-3 Plätze)
7-monatiges Stipendium
www.grk2162.med.fau.deEmail: [email protected]