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Controlled Environment Laboratory and Cleanroom Equipment Solutions for Life Science, Pharmaceutical, Biomedical and Industrial Research Applications Worldwide Edition, 2010/2011 Guide to Esco Products and Services
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Controlled Environment Laboratory and Cleanroom Equipment Solutions for Life Science, Pharmaceutical, Biomedical and Industrial Research Applications

Worldwide Edition, 2010/2011

Guide to Esco Products and Services

Esco Product Guide

Guide to Esco Products and Services

Table of Contents:

Corporate Profile ......................................................................... 2

Biological Safety Cabinets ........................................................... 5

Cleanroom Products .................................................................... 6

Compounding Pharmacy Equipment ......................................... 7

Containment / Pharma Products ................................................. 8

CO2 Incubators ............................................................................. 9

Ductless Fume Hoods ................................................................. 10

In Vitro Fertilization Workstations ........................................... 11

Lab Animal Research Products .................................................. 12

Laboratory Fume Hoods ............................................................ 13

Laboratory Ovens and Incubators ............................................ 14

Laminar Flow Clean Benches .................................................... 15

PCR Products .............................................................................. 16

Ultralow Freezers ....................................................................... 17

After Sales Services .................................................................... 18

1

• A leader in the development of controlled environment,

laboratory and cleanroom equipment solutions.

• A world leader in biological safety cabinets.

• Headquartered in Singapore.

• North American facilities in Pennsylvania and Ohio

Sales, service, logistics for US & Canada.

• Other Esco locations in Bahrain, China, India, Malaysia,

Netherlands, UK.

• Group total of more than 500 employees.

• Distributors in more than 100 countries.

• Products independently tested to international standards.

• Large R&D investments, world leading technologies.

• State-of-the-art production, vertically integrated, 300,000

sq. ft. floor space.

• Worldwide service.

Welcome to Esco

Pictured: Esco Micro Pte. Ltd. is headquartered in Singapore, a modern city state located in Southeast Asia with a population of more than 4 million. From Singapore, Esco manages operations throughout the world.

Esco’s Vision is to provide enabling technologies for scientific discoveries to make human lives healthier and safer.

Pictured: Esco operates 300,000 sq. ft. of state-of-the-art manufacturing space.

2

Esco Product Guide

Global Network

Products and Application

Esco Controlled Environment Equipment Solutions

Laboratory Equipment

Biosafety and Laminar Flow

•ClassIITypeA2Biological Safety

Cabinets

•ClassIITypeB2Biological Safety

Cabinets

•ClassIIIBiologicalSafety Cabinets

•HorizontalLaminarFlow Clean Benches

•InVitroFertilizationWorkstations

•LaboratoryAnimalResearch Workstations

•PCRCabinets

•VerticalLaminarFlow Clean Benches

Fume Hoods

•DuctlessFumeHoods

•ExhaustBlowers

•FumeHoodAirflowMonitors

•FumeScrubbers

•LaboratoryFumeHoods

Incubators and Ovens

•CO2 Incubators

•ForcedConvectionLaboratory Incubators

•ForcedConvectionLaboratory Ovens

•LowTemperatureBOD Incubators

•NaturalConvectionLaboratory Incubators

•RemoteMonitoring,DataLogging,

and Programming Software

Life Science

•PCRThermalCyclers

Not Available in North America

Cold Chain Storage

•UltraLowTemperatureFreezers

Cleanroom Equipment•AirShowers

•GarmentStorageCabinets

•PassBoxes

•SoftCapsuleCleanrooms

•StraddleUnits

•TransferHatches

Pharmaceutical Equipment•CytotoxicSafetyCabinets

•DownflowBooths

•PharmacyIsolators

•PowderWeighingBalanceEnclosures

3

An integral part of our business plan-ning effort is based on managing a robust research and development pro-gram in Singapore, Shanghai and the USA, balanced against an investment in service support, training and cus-tomer education. Compared to indus-try averages, Esco invests a significant percentage of annual revenues in research and development. As a result of our investment, and with continuous

feedback and idea evaluation among our

research, global sales, marketing, pur-

chasing and manufacturing teams; Esco

products reflect the best contemporary

designs in performance, ergonomics and

customer satisfaction.

• 70 Engineers located in Technology

centers in Singapore, China, Indonesia

and USA

•Growing patent portfolio

•Core competencies:

- Embedded system, sensor and soft-

ware development and integration

- Containment engineering for bio-

hazards, chemical vapors and haz-

ardous powders

- Temperature, humidity, gas and en-

vironmental control

- Computational fluid dynamics

- And many more

Continuous Research and Development

Product Development and Innovation

Esco's manufacturing advantage stems from our extensive degree of vertical in-tegration, enabled by our world-leading throughput. All processes, with few ex-ceptions, are performed in-house. This allows us to achieve quality and reliability that is truly world-class. Our plant capa-bilities include:• Incoming materials inspection and

warehousing•CNC-controlled sheet metal fabrication

and welding• Environmentally-friendly powder coat-

ing lines• Electromechanical final product

assembly

• Electrical / electronics sub-assembly•Multi-step electrical and physical per-

formance testing• Independent quality control at each

step in the production cycle•Microbiology, chemistry, containment

test labs• Production output of more than 10,000

units per year

Esco's focus on quality and timeliness is relentless. Continuous improvement is a mantra. Cross functional teams from Esco Production, R&D, Quality Assurance, Senior Management, are regularly assem-bled to review and implement areas for improvement.

Quality,Cost,Productivity,Effectiveness,Timeliness

Manufacturing 4

Esco Product Guide

Esco Biological Safety Cabinets represent more than 20 locally, regionally and internationally-recognized certifications. These accreditations testify to the enhanced performance of Esco products in biological and microbiological applications.

Esco is a world leader in biological safety

cabinets, offering the industry's widest

product range, with thousands of instal-

lations in leading laboratories in more

than 95 countries around the globe.

Esco's biological safety cabinets have

earned more independent certifications,

in more countries, in more languages,

than any other product, demonstrating

our commitment to the industry's best

safety and quality.

Features:

•ULPA filters with >99.999% effi-

ciency for particle size between 0.1

to 0.3 microns.

• Low noise level.

• Energy savings.

• Ergonomic design.

Product lines:

•Class II, Type A2 Biological Safety

Cabinets.

•Class II, Type B2 Biological Safety

Cabinets.

•Class III Biological Safety Cabinets.

• Formalin Vaporizers.

•Options and Accessories.

Pictured: Esco Biological Safety Cabinets

TheSafetySolutionforLifeScienceLaboratories

Biological Safety Cabinets

5

Solutions for Cleanroom Applications

Cleanroom Products

Since 1978, Esco has been a pioneer in the development of cleanroom technology.

Today, Esco operates 300,000 square feet

of state-of-the-art cleanroom equipment

manufacturing floor space with more

than 400 employees. Our vertically in-

tegrated capabilities include CNC sheet

metal fabrication, stainless steel fabrica-

tion, electro-mechanical assembly, and

complete performance testing of all prod-

ucts before shipment.

Integrated sourcing from the world’s

leading component suppliers including

Swedish Camfil-Farr® HEPA/ULPA filters,

German ebm-papst blowers and fans,

enables us to meet your Cleanroom

Equipment requirements at a competi-

tive price with rapid delivery.

Esco Cleanroom products include fan

filter units, air showers for cleanroom

environments, as well as modular clean-

rooms designed for small laboratories.

Backed by decades of experience, Esco

Cleanroom Products offer state-of-the-

art designs compliant to the latest inter-

national standards.

Product lines:

•Air Showers.

• Pass Box and Transfer Hatches.

• Soft Wall Cleanrooms.

• Laminar Flow Straddle Units, Single

and Double.

•Garment Storage Cabinets.

•Cleanroom Apparel and Clothing.

Pictured: Esco Cleanroom Products

6

Esco Product Guide

Esco compounding pharmacy equipment includes a complete range of barrier isolators, NSF listed biological safety cabinets and clean benches.

Esco Compounding Pharmacy Equipment

provides a safe and clean environment

for compounding of sterile drug prepa-

rations and IV admixtures in compliance

with USP 797 criteria. Depending on the

nature of compounds being processed,

Esco Compounding Pharmacy Equipment

can be selected for any of two work zone

relative pressure options, all of which fea-

ture vertical laminar airflow across the

work surface to assure ISO Class 3 level

cleanliness within the work area.

Only Esco offers:

•ULPA filters tested to a typical efficiency

of >99.999% for 0.1 to 0.3 micron

particles. ULPA filters last as long as

conventional HEPA filters and have

similar replacement costs.

• ISOCIDE™ antimicrobial coating on

all powder coated surfaces eliminates

99.9% of surface bacteria within 24

hours of exposure.

• Barrier isolators and biological safety

cabinets utilize stainless steel interiors

with coved corners.

• Barrier isolators feature built-in digital

airflow and pressure displays.

Product lines:

•Cytotoxic Safety Cabinets.

•Compounding Aseptic Isolators.

•Compounding Aseptic Containment

Isolators (Recirculating).Pictured: Esco Compounding Pharmacy Equipment

ThePremiumSolutionforSterileDrugCompounding

Compounding Pharmacy Equipment

7

Esco Solution for Containment / Pharma Applications

Containment / Pharma Products

Esco offers a complete range of solutions designed for pharmaceutical processing in both the containment and aseptic processing fields.

The increasing potency of today's phar-

maceutical compounds, as well as de-

manding health and safety requirements,

have led to a greater need for contain-

ment equipment in the manufacture of

pharmaceuticals. Rapid regulatory devel-

opments have also occured in the aseptic

processing field, pushing manufacturers

of parenterals and aseptic products to

meet ever-increasing quality criteria.

Pharmaceutical dispensing, sampling

and charging operations are now safer

and more efficient with the Esco range

of Pharmacon™ Downflow Booths.

Harnessing Esco's experience of close

to 30 years in clean air and containment

equipment design for the pharmaceuti-

cal industry, these booths offer depend-

able performance in compliance with the

latest environmental and operator safety

standards.

Laboratory operations involving weigh-

ing, mixing and dispensing hazardous

or nuisance powders can now be per-

formed safely and economically with the

Esco Powdermax 1 Powder Weighing

Balance Enclosure.

Product lines:

•Downflow Booths.

• Powder Weighing Balance Enclosures.

•Aseptic and Containment Isolators.

Pictured: Esco Containment / Pharma Products

8

Esco Product Guide

Sleek, reliable and intuitive, Esco CelCulture CO2 incubators

provide comprehensive sample protection that brings your

scientific dreams one step closer to reality.

Introducing Esco CelCulture® - world class CO2 incubators from Esco with the technologies and compliance to prove it. Precise parameter control, robust contam-ination control with ULPA filtration system and 90°C moist heat decon.

CO2 incubators are widely used in scien-tific research to grow and maintain cell

cultures. Typical fields of application in-

clude tissue engineering, in vitro fertiliza-

tion, neuroscience, cancer research and

other mammalian cell research.

Features:

• Stable, uniform distribution.

•ULPA filters.

• Full stainless steel interior, ISOCIDE

antimicrobial coating on exterior

surface.

• Intelligent data & event Logger.

•Alarm system.

• 90˚C moist heat overnight decontami-

nation cycle. Pictured: Esco CelCulture® CO2 Incubators

Cradle for Beautiful Cells

CO2 Incubators

9

TheSafe,EnergyEfficientSolutionforModernChemistry

Ductless Fume Hoods

Esco Ascent Ductless Fume Hoods provide protection to

both laboratory personnel and the environment from toxic

fumes.

Esco Ascent Ductless Fume Hoods are

quickly becoming a viable alternative to

conventional fume hoods. Unlike conven-

tional fume hoods, these hoods filter out

chemical fumes and recycle air directly

back to the laboratory, providing energy

savings, personnel and environmental

protection, convenience as you do not

have to deal with complicated ducting

systems, and mobility, since ductless

hoods are independent systems which

do not require connection to extraction

systems.

Esco ductless fume hoods are inde-

pendently tested by INVENT-UK for

the ability to filter contaminated air

with efficiency and retention capac-

ity as required by the British Standard

BS 7989 and French Standard AFNOR

NF X 15-211. Fume containment and

airflow uniformity meet the require-

ments of ASHRAE 110-1995, BS 7258,

EN 14175-3 and AFNOR NF X 15-203.

The Esco combination of high perfor-

mance and carbon filtration opens new,

cost effective applications for fume hood

technology in schools, classrooms and

laboratories. Associated products include

Esco chemical storage cabinets.

Pictured: Esco Ductless Fume Hoods

10

Esco Product Guide

Esco IVF workstations are specially designed for use in

fertility laboratories in the fields of human and animal

reproduction.

Pictured: Esco IVF Workstations

Esco In Vitro Fertilization Workstations

In Vitro Fertilization Workstations

A controlled work environment is of high

priority due to the complexity of the pro-

cess. This includes hygienic conditions

to minimize microbial contamination, a

warmed work surface for the sustenance

of biological matter and provisions for the

use of microscopes.

The Labculture IVF workstation in-

corporates a number of features to

ensure operator comfort and enhanced

productivity:

• Theworkstationinteriorisconstructed

of stainless steel, making the work zone

easy to clean. The interior surface will

not chip, rust or generate particles.

• The ergonomically designedwork

surface with a curved front edge

is designed for maximum operator

comfort.

• Built-inwarmwhite,electronicallybal-

lasted, 5000k lighting provides excel-

lent illumination of the work zone and

reduces operator fatigue. The reliable

lighting system is zero-flicker and in-

stant start.

• Theremovableperforatedfilterdiffuser

provides protection to the filter and im-

proves airflow uniformity.

11

Esco Solution for Animal Research Laboratories

Lab Animal Research Products

Animal research, cage changing and bedding disposal

procedures are now simpler, safer and more productive with

the Esco range of VIVA® Lab Animal Research Products.

Esco experience in clean air and contain-

ment technologies extends to lab animal

research products to help protect the

investigator, animal technicians, animals

and the environment during research,

cage changing and bedding disposal

procedures. Esco lab animal research

products help laboratories comply with

NIOSH recommendations to create a

safer, more productive and healthier work

environment.

Esco applies decades of experience in

clean air technologies to the animal re-

search laboratory, protecting personnel

and the laboratory environment from

hazards related to the equipment, ma-

terials and practices used in performing

routine animal husbandry; hazards relat-

ing directly or indirectly to animal con-

tact; hazards related to the technique

or materials or biohazardous substances

that may be used during the course of

animal research.

Product lines:

•Universal Access Animal Containment

Workstations.

•Dual Access Animal Containment

Workstations.

• B e d d i n g D i s p o s a l A n i m a l

Containment Workstations.

•Air Showers.

Pictured: Esco Lab Animal Research Products

12

Esco Product Guide

Laboratory fume hoods serve to control exposure to toxic, offensive or flammable vapors, gases and aerosols.

Pictured: Esco Laboratory Fume Hoods

LaminarTopographyandPerfectProtectionPerimeter

Laboratory Fume Hoods

The laboratory fume hood is a type of local exhaust ventilation system (engineer-ing control). A typical fume hood is a cabi-net with a moveable front sash (window) made out of safety glass. A properly used and functioning fume hood exhausts haz-ardous gases, dusts, mists, and vapors from a confined location and helps pro-tect workers from inhalation exposure.

Esco fume hoods have been indepen-dently tested by INVENT-UK to pass the American standard ASHRAE 110-1995 and British Standard BS 7258 (deter-mining fume containment capability). They have also been successfully tested for fume containment specified in the European Standard EN 14175-3.

Product lines:

•General Purpose Benchtop Hoods.

•Acid Digestion Hoods.

• Perchloric Acid Hoods.

• Radioisotope Hoods.

• Floor Mounted Hoods.

•High Performance, Low Flow Hoods.

• Educational Hoods.

• Polypropylene Hoods.

•Chemical Fume Scrubbers.

• Exhaust Blowers.

13

Reliable Performance For Universal Applications

Laboratory Ovens and Incubators

Introducing Esco Isotherm® - world class laboratory ovens

and incubators from Esco with the technologies and

compliance to prove it.

Esco Isotherm® - world class laboratory

ovens and incubators encompass ergo-

nomics, intuitive interfaces, microproc-

essor PID controls with programming

options, a 4-zone heated air jacket and

a precisely tuned and tested ventilation

and insulation package, all supported by

Esco’s solutions - based sales and service

representatives worldwide.

Product lines:

• Forced Convect ion Laboratory

Ovens.

• Forced Convect ion Laboratory

Incubators.

•Natural Convect ion Laboratory

Incubators.

• Low Temperature BOD Incubators.

•Voyage r Remote Mon i to r ing ,

D a t a l o g g i n g , P r o g r a m m i n g

Software.

Pictured: Esco Laboratory Ovens and Incubators

14

Esco Product Guide

Esco is the world leader in premium laminar flow cabinets for the global life sciences market.

Pictured: Esco Laminar Flow Clean Benches

TheLeadingSolutionforResearchLaboratories

Laminar Flow Clean Benches

Esco is an industry leader in the develop-ment of professional quality laminar flow clean bench cabinets. With tens of thou-sands sold throughout the life sciences market worldwide, Esco has reinforced its reputation for dependability by providing reliable protection for samples and work processes in a multitude of applications.

Our selection of Vertical, Horizontal and Specialty clean bench cabinets offers a variety of choices for installations where high quality construction is essential. Our clean bench cabinets are aerodynamically engineered and use only premium quality ULPA filters with integrated motor/blower assemblies for quiet operation and long service life.

Since 1978, Esco has emerged as the industry leader producing laminar flow cabinets that are the premium selection

for the discerning researcher and offer-ing a combination of value, high qual-ity construction, low operating noise levels, and a wide product range to suit all budgets.

15

Esco Reliable Solution for PCR Process

PCR Products

Esco PCR products are used in genomics, proteomics, molecular biology and forensic sciences where DNA amplification is required.

Polymerase Chain Reaction (PCR) is an

in vitro method of nucleic acid synthe-

sis useful in the detection and analysis

of DNA and RNA in cell and molecular

biology investigations. Through PCR, a

small, unique segment of DNA can be

specifically replicated, exponentially am-

plified and easily analyzed. Because PCR

depends on repeated cycles of heating

and cooling within a sample block, rapid

temperature ramping, precise tempera-

ture control, block uniformity and flex-

ible segment programming are essential

performance attributes of a Thermal

Cycler.

Esco offers a choice of Conventional

Thermal Cycler and Real Time Thermal

Cycler models designed to meet critical

requirements for all kinds of PCR pro-

cesses, such as, Gradient PCR, Touch

down PCR, High throughput PCR, in

situ PCR and so on, using a variety of

PCR tubes, strips, plates and slides. The

Swift thermal cyclers use state of the art

Peltier temperature control technology

to achieve and maintain precise control

and fast ramp rates with minimal over

or under-shoot for process speed and

accuracy.

Esco real-time and programmable ther-

mal cyclers, shaking micro incubators and

accessories fulfill an emerging demand

for complementary products found in

the same laboratory environments as

the company’s clean air and laminar flow

line.

Not available in North AmericaPictured: Esco PCR Products

16

Esco Product Guide

The Perfect Storage Environment for Beautiful Cells.

Pictured: Esco Lexicon® Ultralow Temperature Freezers

EscoUltralowTemperatureFreezers

Ultralow Temperature Freezers

• Energy Eff ic ient - 130mm (5")

foamed polyurethane insulation,

triple gasket seal, full wrap copper

evaporator, balanced system design.

•Quiet - extremely low operating

noise levels ensure a perfect working

environment.

• Reliable - proven components, dual

condenser fans; clean, dry and leak-

free refrigeration systems.

• Balanced Design - thermodynami -

cally engineered for precise balance

between high and low stages, improves

operating efficiency and reliability.

•Warranty - 5 years on compressors, 2

years on complete system.

•Capacity - larger volumes than the

competition in the same class.

17

Esco After Sales Services

After Sales Services

Parts Availability

Whenever service is needed and parts are required, minimizing downtime is a critical objective. Statistical usage analysis helps

Esco predict parts life, permitting Esco to manage logistics and stage proper inventories around the world. The combination of

predictive maintenance, historical data and geospecific proximity assures our customers that parts and labor are available when-

ever service is scheduled through the local sales organization.

Registration, Documentation and Instruction

Quality control at Esco extends from research and development through engineer-

ing, manufacturing, shipment, delivery and customer feedback. Esco maintains an

aggressive program to encourage warranty card registration by mail, email or online

submittal so that we know where Esco products are located and how they are being

used. Data from our warranty registration program is confidential and provides us

with valuable contact information should we ever need to notify you about your

Esco product.

All Esco products include unique serial numbers for identification.

Documentation for all performance tests is archived and maintained for customer

reference.

Online Technical Information

Site preparation instructions are useful before product arrival and installation.

Installation and start-up manuals, operations manuals and quick reference guides

are available anytime from the Esco Library online. An interactive online LiveSupport™

concierge center accessible through the Esco Web site offers extended hours of opera-

tion. LiveSupport permits users to dialogue directly with Esco personnel.

References and Links

For more about Esco products, markets, employment opportunities, history, edu-

cation, information resources, and Singapore, visit our information portal at

www.escoglobal.com.

LIVE SUPPORTescoglobal.com

LIVE SUPPORTescoglobal.com

18

EscoTechnologies,Inc.•2940TurnpikeDrive,Units15-16•Hatboro,PA19040,USAToll-FreeUSAandCanada877-479-3726•Tel215-441-9661•Fax215-441-9660us.escoglobal.com•[email protected]

EscoMicroPte.Ltd.•21ChangiSouthStreet1•Singapore486777Tel+6565420833•Fax+6565426920•[email protected]

Esco Global Offices | Breukelen, The Netherlands | Kuala Lumpur, Malaysia | Manama, Bahrain | Mumbai, India | Philadelphia, USA | Salisbury, UK | Shanghai, China | Singapore ©20

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