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Copyright © 2016 Sirio Pharma Co., LtdCopyright © 2017 Sirio Pharma Co., Ltd 2017/11/171
Gummy Vitamins
——An Innovative Solution for Human Nutrition
Danny Gan, PhD
Delivering Value for Health
Outline
2017/11/172
1. Global VDS Market Overview
2. Dosage Format Introduction of Gummy
3. Market and Product Trend of Gummy Vitamins
4. Innovation Makes Gummy Vitamins Different
5. Comprehensive Gummy Vitamins Offering
Delivering Value for Health4Reference:
Nutrition Business Journal, Global
Supplement Business Report 2016
Global Dietary Supplement Market Overview
Global Supplement Industry Sales and Growth, 2004-2020e
“NBJ forecasts that the global supplement market will grow at a
CAGR of 6.1% from 2015 to 2020. Market will be boosted by strong
growth in Rest of Asia and Eastern Europe where growth is
expected to be in the 9% range annually”
(unit: Million, USD)
1
2
3
Global Supplement Industry Sales by Country or Region
Total western Europe take 15% market share of global VDS market,
while total eastern Europe account for 5% market share which
represent one of the highest growth in future.
Delivering Value for Health5Reference:
Nutrition Business Journal, Global
Supplement Business Report 2016
Global Vitamin & Mineral Market Overview
Note: size of each bubble represents the respective
sales volume in 2014
USA
China
Canada
Mexico
Australia & New
Zealand
Latin America
Rest of Asia
Japan
Western Europe
Low growth High growth
High spend per capita
Low spend per capita
East Europe & Russia
■ US leads the global supplement market with the highest per capita expenditure, while China
represents one of the highest market growth in supplement.
Delivering Value for Health 2017/11/176
■ Top trends lists below are from international market research organizations.
■ Get Real: The allure of Authenticity
■ Personalize It
■ Extraordinary
■ Aging: A changing Narrative
■ Faster Shopping
■ Identity in Flux
■ Consumers in Training
■ Post-purchase
■ Privacy and Security
■ Wellness As Status Symbol
■ In Tradition We Trust
■ Power to the Plants
■ Beauty Supplements
■ Waste Not
■ Time is of the Essence
■ The Night Shift
■ Balancing the Scales –
Health for Everyone
■ Blurring with food/drink
■ Clean Supreme
■ Disruptive Green
■ Sweeter Balance
■ Kitchen Symphony
■ Body in Tune
■ Plain Sophistication
■ Encapsulating Moments
■ Beyond Pester Power
■ Fuzzy Borders
■ Seeds of Change
2017 Food & Nutritional Product Trends
Reference:
1. Euromonitor International, ‘Top 10 Global Consumer Trends for 2017’
2. Mintel, ‘Global Food and Drink Trends 2017’
3. Mintel, ‘Category Insight: Vitamins & Dietary Supplements’
4. Innova Market insights, ‘Food and Drink Top 10 Trends for 2017’
Delivering Value for Health
2011 2013 2015
I would prefer to get all my daily nutritional requirements in the food I eat, rather than take additional supplements.
The percentage of customers that prefer to get nutrients in the food rater than pills and capsules is increasing every year (figure 1).
54%60%
78%
figure 1
Consumer insight for Vitamin & Mineral Supplement
Source: NMI 2015 Nature Marketing Institute7
Delivering Value for Health
Top 3 VDS Dosage Format in US
Dose FormatSales Volume
& % ShareVolume growth Value growth
Share value % change
Tablet$1,631 million, 28%
Softgel$1,212 million, 21%
Gummy Vitamin
$821 million, 14%
-0.9%
vs. YA
+0.23%
vs. YA
-1.03%
vs. YA
+1.30%
vs. YA+2.49%
vs. YA
+8.71%
vs. YA+13.02%
vs. YA+1.21%
vs. YA
-0.27%
vs. YA
Source: NMI 2015 Nature Marketing Institute9
Delivering Value for Health 2017/11/1710
42%
41%
29%
28%
26%
Capsule
Tablet
Gummy-type
Softgel
Chewable
US
46%
36%
32%
24%
21%
15%
Tablet
Capsule
Effervescent/Dissolving…
Lozenge
Liquid
Gummy-type
Germany
45%
38%
36%
34%
33%
Capsule
Nutritional bars
RTD Bev
Tablet
Gummy-type
Mexico
42%
27%
27%
26%
24%
16%
Softgel
Tablet
Capsule
Lozenge
Dripping pill
Gummy-type
France
42%
33%
31%
29%
27%
11%
Chewable
Capsule
Tablet
Sachet
RTD Bev
Gummy-type
China
44%
42%
41%
37%
36%
5%
Tablet
Capsule
Nutritional bars
RTD Bev
Fast dissolve tablet
Gummy-type
Brazil
Source: NMI, 2016 Supplements/OTC/Rx Consumer Trends Report
Preference of Supplement Dosage Format
Delivering Value for Health 2017/11/1711
In US, you can find gummy products
everywhere on shelves in the vitamin
supplement category in modern trade
US Gummy Vitamin Product
Delivering Value for Health 2017/11/1712
In UK, gummy products were well accepted in
the children’s health category
UK Gummy Vitamin Product
Delivering Value for Health
Gelatin and Pectin based Gummies
2017/11/1713
Gelatin
• Contained in the cell walls of plants,
mainly extracted from citrus fruits
and apple.
• Tender
• Melting temperature: 40℃
• Derived from collagen obtained
from animal by-products such as
pigskin, cattle bones, cattle skin
• Tough chewiness
• Melting temperature: 35℃
Pectin
Vegetable
81%
19%
Gelatin
Pectin
Source: 2013 NMI database
Global Production Volume
• Gelatin is the major gelling
agents used
• Pectin is of vegetarian source, a
potential trend
Delivering Value for Health
Gummy Vitamin is Happy Nutrition
2017/11/1714
Sweet, delicious
while nutritionalEasy to swallow,
no need water
More food-like,
less medicine
image
Portable and
convenient
Delivering Value for Health
Research & DevelopmentGrowth Maturity Decline
Sale
s
Overview of Global Gummy Vitamin Market
2017/11/1716 Source: Innova database; 2015-2016 IRI
• 2016, the gummy retail market is $821m in total, and the overall sales growth rate is 13%;• In which gummy vitamin for children is $179m;• 2017, total sales forecast is more than $1,000M .
Delivering Value for Health
The Gummy Vitamin Categories Trend
2017/11/1717
1
10
100
1,000
10,000
100,000
1,000,000
Unit: thousand
2015 2016
The multivitamin is the largest category in US. In 2016, multivitamin gummies reached $531m sales. Probiotic gummy became the second largest category, $54m sales. Calcium the 3rd, $44m sales. Vitamin C $43m, Biotin $41m.
68%5%
6%21%
Multivitamin
Probiotic
Calcium
Others
65%7%
5%
23%Multivitamin
Probiotic
Calcium
Others
2015 US market reached $732M, 68% is Multivitamin category
2016 US market reached $831M, 65% is Multivitamin category
The retail sales value of VMS gummy vitamin in 2015-16 in different categories
Source: IRI 2016
Delivering Value for Health
Adult Gummy Generates The Big
2017/11/1718
2962.586 2674.293
529499.8633184.6
0
200000
400000
600000
800000
1000000
2015-Value Sales 2016-Value Sales
Adult 50+ Teen Kid All (age>2/4)
20% increase in value &
4% increase in share
42% decrease in value &
0.7% decline in share
19% increase in value &
0.2% increase in share;
4% decrease in value &
3.4% decline in share;
10% decrease in value &
0.1% decline in shareAdult is the largest and growing segment
A new and rising segmentation is teen’s group
Source: IRI 2016
Gummy Segmentation by Users’ Age
Adult
50+
Teen
Kid
All age
Gummy Market Changes by Users’ Age
Delivering Value for Health
Gummy Expansion for Women
2017/11/1719
543202.2 597615.3
122024.6151021.461453.03
72681.84
0
200000
400000
600000
800000
1000000
2015-Value Sales 2016-Value Sales
Men Women Not specified
(unit:$1,000)
1,Gummy market segmentation was growing stronger,
differentiated products for women & men grew more.
2,In women, age 50+ is dropping significantly.
Source: IRI 2016
Gummy Segmentation by Users’ Gender
18.3% increase in value &
0.3% increase in share
23.8% increase in value &
1.8% increase in share
10% increase in value &
2% decline in share
Men
Women
Overall
Gummy Market Changes by Users’ Gender
2015-Value
Sales in 000
USD
2016-Value
Sales in 000
USD
% Value Sales
Change YA
Women 50+ 7606.594 3444.286 -54.72%
Teen girls 7424.091 8410.525 13.29%
Women 106993.9 139166.5 30.07%
Gummy Segmentation by users’ age (Female)
Delivering Value for Health
Gummy Dominates the Children’s VDS Market
2017/11/17
300
211
104
38 30 23 18 8 5 4 20
50
100
150
200
250
300
350
Source: IRI 2016; Product images are from brand websites
SKUs
Market Value
56.11%16.56%
9.61%
7.52%10.20%
GUMMY
TABLET
LIQUID
DROP
Others
2016 US Children’s VDS Market Overall :
$370m2016 US Children VDS Market
•More than 56% of VDS market value is
generated by the gummy format
•The gummy vitamin is the No.1 popular format in
children’s VDS category.
20
Delivering Value for Health 2017/11/1721
1.07%
0.38%
0.32%
0.31%
0.27%
0.24%
0.23%
0.21%
0.19%
0.19%
1
2
3
4
5
6
7
8
9
10
CAPSULE
LIQUID
GUMMY
GUMMY
GUMMY
GUMMY
GUMMY
GUMMY
GUMMY
CAPSULE
Top-10 New Launches by Market shareDosage forms
2016 US top10 Children’s VDS Products
4.77%
4.07%
3.37%
3.21%
2.99%
2.71%
2.68%
2.68%
2.41%
2.29%
1
2
3
4
5
6
7
8
9
10
CAPSULE
GUMMY
GUMMY
GUMMY
TABLET
GUMMY
TABLET
GUMMY
TABLET
DROP
Top-10 Products by Market shareDosage forms
P
r
i
v
a
t
e
l
a
b
e
l
Source: IRI 2016;
Product images are from brand websites
Delivering Value for Health
US No.1 Gummy Brand - Vitafusion
2017/11/1722
Classic products
Featured Products
Delivering Value for Health
US Most Popular Children’s Gummy Brand
2017/11/1723
Multivitamin Vitamin C Omega3 Calcium&D3 D3 Fiber ProbioticFruit & Veggie
Classic products
High-end Product Line with New & Innovative
concept
Exclusive Product Line with Cartoon
Image
Multivitamin
•Twisting two
gummies
•33% less sugar
Multivitamin
•Clover honey
and fruit juice
Immunity (C+D+Zinc)
•Clover honey and
fruit juice
Multivitamin Multivitamin Multivitamin
Source: http://www.gummyvites.com/en/Lil-Critters
Delivering Value for Health
Integrated R&D Force for Sirio’s Gummy
2017/11/1725
• Tasting experts to engage all
senses to taste gummies, flavors of
happiness
• Technology to mask unpleasant
odors from special ingredients
c-GMP standards
Heavy mental analysis, microbial
analysis… • Stability test(18-24 months) for appearance and
efficacy / texture analysis …
• Formulation designed based on
pharmaceutical standards
• Nutrients meet RDA guideline
You can choose an existing formula, or our R&D lab
can create custom prototypes for you.
Delivering Value for Health26
Optimization of Detection Method
Detection of biotin in gummy by HPLC before and after method optimization
Data Source: Sirio Pharma R&D Center
Before After
Delivering Value for Health27
Optimization of Detectable Rate
0
20
40
60
80
100
120
0 6 12 24
Detectable rate (Before) %
Detectable rate (After) %
0
20
40
60
80
100
120
0 6 12 24
Detectable rate (Before) %
Detectable rate (After) %
Detectable rate of vitamin D3 in gummyDetectable rate of vitamin A in gummy
Month Month
Data Source: Sirio Pharma R&D Center
Delivering Value for Health28
Stability Testing Method Setup
0%
20%
40%
60%
80%
100%
120%
0 3 6 9 12 18month
Dete
cta
ble
Rate
Vitamin A
Vitamin D
Vitamin E
Vitamin B1
Vitamin B2
Vitamin B3
Vitamin B5
Vitamin B6
Vitamin B12
Vitamin C
Biotin
Folic Acid0%
20%
40%
60%
80%
100%
120%
0 1 2 3 month
Dete
cta
ble
Rate
Vitamin A
Vitamin D
Vitamin E
Vitamin B1
Vitamin B3
Vitamin B5
Vitamin B6
Vitamin B12
Vitamin C
Folic Acid
Degradation Rate of Vitamin During the Shelf Life
Degradation Rate of Vitamin Under Acceleration Conditions
Data Source: Sirio Pharma R&D Center
Delivering Value for Health29
Effect of different packaging materials for gummy
Effect of different process-treated packaging for gummy
Packaging materials: for sample A
and B are aluminized plastic and pure
aluminum, respectively;
Storage condition: Room
temperature for 3 months, 30
pieces/packaging.A B
A B C D E
Process-treated packaging : for sample A
- E are fulfilled with different content of
nitrogen, respectively;
Storage condition: Room temperature for
18 months, 30 pieces/PET bottle.
Packaging Study
Data Source: Sirio Pharma R&D Center
Delivering Value for Health
38
35 3534
32
30.5
40
3635
34 34
30.7
0 3 6 9 12 18
Vitamin C
Batch 1303002 Batch 1303022
Tested product: Multiviatmins Gummy 025 (sugar coated)
Ingredients: Vit C 30mg, Vit A 50 μgRE , B6 1.4mg; conditions: 25℃, 60%RH;
Standard: Vit C ≥30mg; Vit B6 ≥1.4mg; Vit A ≥50μg RE
Sharing of Stability Data
2017/11/1730 Source: Sirio Pharma (internal stability data)
1.9
1.8
1.9
1.8
1.7
1.9
2.2
1.9
1.8
1.9
1.7
1.8
0 3 6 9 12 18
Vitamin B6
Batch 1303002 Batch 1303022
56 56
54 5453
51
56 5655
5455
51
0 3 6 9 12 18
Vitamin A
Batch 1303002 Batch 1303022
(month)(month)
(month)
Data Source: Sirio Pharma R&D Center
Delivering Value for Health 2017/11/1733
Bright, Happy, Unlimited Flavors, Colors
Natural: extracted directly from its natural source or mixed with other natural flavors.
Oil/Polished Sugar CoatedSurface
SugarLow
SugarSugar Free
Reducing Sugar≥10%≈ 8 Kcal per 2.5g
Gummy
Sugar (Reducing sugar
+ Sucrose) ≤5.0%≈ 3-5 Kcal per 2.5g
gummy
Sugar (Reducing sugar
+ Sucrose) ≤0.5%≈ 3-5 Kcal per 2.5g
gummy
Sirio’s Comprehensive Offering of Gummy
Delivering Value for Health 2017/11/1734
We can manufacture any shape depending on the customer’s needs. These are some
examples of mold shapes used for gummies.
Production Size: 2-4g (1-6.5g in Y2018) for all shapes
Panda2.5-3g
Round2-3g
Smiling
face2-3g
Square3-4g
Fish2-3g
Orange
slice2-4g
Shell2.5-3g
Strawberry2.5-3.5g
Dinosaur2-3g
Happy
bear3-4g
Sea star2-3g
Round2-3g
Koala2-4g
More molds are under the
process of development...
Sirio’s Comprehensive Offering of Gummy
Delivering Value for Health
Immunity and Antioxidant
Circulatory and Heart Health
Cognitive and Memory
Eye Health
Digestive Health
Throat Cooling
Multivitamin/ Vitamin C/ Astaxanthin
Omega 3/ CoQ10/ Krill oil
DHA/ Phosphatidylserine
Lutein / Blueberry
Inulin/ GOS/ FOS
Eucalyptus-mint
35
Protein/ B complex / B12/ Caffeine
Prenatal multivitamin
Calcium/ D3/ Mushroom powder
Melatonin / GABA / Theanine
Garcinia cambogia / Green coffee bean
Collagen / Biotin
Sports nutrition
Weight Management
Mood and Sleep Health
Bone Health
Prenatal Health
Beauty Aids
Sirio’s Comprehensive Offering of Gummy
Delivering Value for Health
Claims for Children’s Gummy Vitamins
Non-GMO ingredients
Natural colors and natural flavors
No preservative added
With no hydrogenated fat
Gluten free
Lactose free
Dairy free
Nut free
Soy free
Vegetarian/Vegan
Sugar free
2017/11/1736
Delivering Value for Health
New Products
Sirio keeps improving manufacturing and product development capabilities…
2017/11/1737
Center-filled Multi-colored Swirl-colored