Brain•••
2004 Sinauer Associates, Inc.
(1ms )(1ms )
(~0.1ms)
2004 Sinauer Associates, Inc.
7
2004 Sinauer Associates, Inc.
http://www.nobelprize.org/nobel_prizes/medicine/laureates/2013/
Ach
(mV)
2004 Sinauer Associates, Inc.
pA)
Neher and Sakmann 1976
Hodgkin, A. & Huxley, A.1963
(Eccles, J.C. )
(stellate ganglion)
2004 Sinauer Associates, Inc.
Ca2+
(mV)
CaA/cm2
(mV)
2004 Sinauer Associates, Inc.
Ca2+EP
SP
EPSP
(mV)
(mV)
(mS) (mS)
(mV
)
(mV
)
AP K:
Ca2+
2004 Sinauer Associates, Inc.
-100mV -60mV 0mV +50mV
Na K
(mV)
(nA
)(n
A)
)( EPSPmEPSPEPSP EVgI
2004 Sinauer Associates, Inc.
EEPSP Takeuchi and Takeuchi,1960
)
)( EPSPmEPSPEPSP EVgIEEPSP
K+ Na+
K+ Na+
(EEPSP)
mVEmVEggE
gg
EEgg
ggEgEgE
EEgEEgII
KNaK
NaEPSP
K
Na
KNaK
Na
KNa
KKNaNaEPSP
KEPSPKNaEPSPNa
KNa
80,55,45.1( 0mV
1
)()(
Ia
Ia
EEPSP
Ia
ENa
EEPSP
ECl
EK
K+ Na+
IPSP
(EIPSP=ECl)
IPSP
EPSP
Ia
Ia
IPSP
EPSP
EPSP
)( IPSPmIPSPIPSP EVgI
Ia
EPSP)
GABA
GABAGABA
EPSP GABA
GABA
IPSP
(mV
)
EPSP (Synapse E1 or E2)
EPSP (Synapse E1 +
E2)IPSP (Synapse
I)
EPSPIPSP (Synapse
E1 + I)
EPSPIPSP (Synapse E1 +
I + E2)
2004 Sinauer Associates, Inc.
AC
Glu
Asp
γGABA
Gly
Ach, Glu, GABA
2004 Sinauer Associates, Inc.
(A) (B)
1
2
3
1
2 3
4
5
2004 Sinauer Associates, Inc.
: mGluR: AMPA
M1~M4
M
2004 Sinauer Associates, Inc.
G
1 GTP2
G G3
G
2004 Sinauer Associates, Inc.
http://sites.sinauer.com/neuroscience5e/animations05.
03.html
IP3
IP3cAMP
D2
2004 Sinauer Associates, Inc.
1
cAMP
2
cAMP3
RNA2004 Sinauer Associates, Inc.
Ca
Ca
1
2
3
45
1 2 3
5
(A)
(B)
(C)
1 2 3
4
4
2004 Sinauer Associates, Inc.
GABA
GABA
GABA
GABA
2004 Sinauer Associates, Inc.
Declarative memorySpatial learning
Procedural memoryMotor learning
A B
EPSP
EPSP
LTP
LTP
Science, 2001
Two synaptic delivery pathways for AMPARs.Both pathways depend on the subunit compositionof AMPA-Rs. To establish plasticity,GluR1/GluR2 heteromers are delivered tosynapses to potentiate synaptic transmission. Tomaintain synaptic transmission, GluR2/GluR3heteromers replace existing synaptic AMPA-Rsindependent of neuronal activity.
• "Neuroscience“ Editors: Dale Purves et al., Sinauer, (ISBN: 978-0-87893-695-3)Hardcover 5th edition (2012)
• Companion Website (free)http://sites.sinauer.com/neuroscience5e
•
• http://www.biol.s.u-tokyo.ac.jp/users/naibunpi/Lecture_Index.html
•20121212 (ISBN9787878-88-4-44-4444--2747474-444-211959595-55-9)
• http://ssl.ohmsha.co.jp/cgi-bin/menu.cgi?&ISBN=978-4-274-21195-9
•2006
•
•
• From Neuron To Brain. 4th Ed. Nicholls, J.G., et al., Sinauer, 2001 (ISBN 0-87893-439-1)
• Ion Channels of Excitable Membranes. 3rd
Ed. Hille, B. Sinauer, Associates, 2001 (ISBN 0-87893-321-2)
,
•
••
••• e-mail: [email protected]• http://www.biol.s.u-tokyo.ac.jp/users/naibunpi/