Harold D. Schultz, Ph.D. · Curriculum Vitae Harold D. Schultz, Ph.D. 4 Translational Research...

Curriculum Vitae Harold D. Schultz, Ph.D.

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Harold D. Schultz, Ph.D.

Biography

CAMPUS ADDRESS: Department of Cellular & Integrative Physiology

University of Nebraska College of Medicine

985850 Nebraska Medical Center

Omaha, NE, 68198-5850

OFFICE TELEPHONE: (402) 559-7167

(402) 559-4438 (FAX)

EMAIL : [email protected]

Predoctoral Education

Ph.D. September, 1977 to June, 1979 Physiology, University of Illinois, Urbana, Illinois.

NIH Trainee in Systems and Integrative Biology.

M.S. September, 1974 to June, 1976 Physiology, University of Illinois, Urbana, Illinois.

B.S September, 1972 to June, 1974 cum laude, Distinction in Physiology, University of

Illinois,Urbana, Illinois.

Postdoctoral Education

NRSA Trainee in Heart and Vascular Diseases (3/1/82 - 4/30/85).

Cardiovascular Research Institute, University of California, San Francisco, CA.

Advisors: John C.G. Coleridge, M.E., Ch.E. Hazel M. Coleridge, M.E., Ch.E.

Training: Sensory and reflex properties of afferent nerves in the heart, lungs, airways, and major

vessels. Reflex regulation of cardiovascular and respiratory function.

Postdoctoral Research Trainee (7/1/79 - 12/31/81).

St. Luke's Foundation for Medical Research. St. Luke's Hospital, Kansas City, MO.

Advisor: Kenneth L. Goetz, M.D., Ph.D.

Training: Reflex regulation of cardiovascular and renal function by cardiac receptors. Neural and

osmotic control of vasopressin secretion.

Responsibilities: Laboratory investigator in cardiovascular-renal research. Laboratory instructor of

cardiovascular physiology for graduate students.

Academic Appointments

Professor of Physiology (7/1/96 - present)

Department of Cellular & Integrative Physiology, University of Nebraska Med Center, Omaha, NE

Chairman: Irving H. Zucker, Ph.D.

Teaching responsibilities: Lecturer of respiratory physiology for medical, graduate, and allied-

health students.

Research interests: Sensory and reflex properties of afferent nerves in the heart, lungs, airways,

and major vessels. Reflex regulation of cardiovascular, respiratory, and renal function. Central

integration of cardiovascular-respiratory reflexes affecting sympathetic and parasympathetic


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nerve activities. Reflex autonomic effects of neuropeptides, natriuretic peptides and vasoactive

peptides. Autonomic dysfunction in heart failure and myocardial ischemia/reperfusion.

Associate Professor of Physiology (6/1/90 - 6/30/96)

Department of Physiology and Biophysics, University of Nebraska Med Center, Omaha, NE

Chairman: Irving H. Zucker, Ph.D.

Adjunct Assistant Professor of Physiology (3/1/88 - 5/31/90).

Department of Physiology, University of California, San Francisco, CA.

Chairman: Zach W. Hall, Ph.D.

Teaching responsibilities: Lecturer, conference leader, and laboratory instructor of cardiovascular,

respiratory, and renal physiology for medical and graduate students.

Associate staff member, Cardiovascular Research Institute (9/26/88 - 5/31/90).

Assistant Research Physiologist (5/1/85 - 3/1/88)

Cardiovascular Research Institute, University of California, San Francisco, CA.

Director: Richard J. Havel, M.D.

Recipient of New Investigator Research Award from National Heart, Lung, and Blood Institute.

Research interests: Sensory and reflex properties of afferent nerves in the heart, lungs, airways,

and major vessels. Reflex regulation of cardiovascular, respiratory, and renal function.Central

integration of cardiovascular-respiratory reflexes affecting sympathetic and parasympathetic

nerve activities. Reflex autonomic effects of atrial natriuretic peptide and other vasoactive

peptides.

Adjunct Instructor of Physiology (7/1/80 - 9/30/81).

Department of Physiology, University of Kansas, Kansas City, KS.

Chairman: Gilbert S. Greenwald, Ph.D..

Responsibilities: Laboratory instructor of cardiovascular physiology for medical students.

Instructor of Pathophysiology (3/1/81 - 9/3/81).

Webster College of Baccalaureate Nursing, St. Luke's Hospital, Kansas City, MO.

Director: Katherine Wendorff, M.S.

Responsibilities: Course director and instructor of pathophysiology for nursing students

Honors, Scholarships, Fellowships

Fellow of the American Physiological Society (FAPS), 2017-present

President Elect, Nebraska Physiological Society, 2017-2018

Senior Editor, The Journal of Physiology, 2016-present

Councilor, Amercian Physiology Society 2016-2019

Golden Heart Member of American Heart Association, 2015-present

UNMC Distinguished Scientist Award, 2014

Chairman, Neural Control and Autonomic Regulation Section, American Physiological Society,

2012-2015

Secretary/Treasurer, Neural Control and Autonomic Regulation Section, American Physiological

Society, 2009-2012

President, Nebraska Physiological Society, 2006-2007

Member, Nebraska Redox Biology Center, Univ. Nebraska Lincoln, 2006- present

Silver "U" Award, Chancellor's Council, University of Nebraska Medical Center, Omaha, 1999

Invited participant, UNMC Research in the 21st Century, retreat, UNMC, 1999

Fellow of the Councils for Circulation and for High Blood Pressure Research, American Heart


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Association (FAHA), 1995-present

Fellow of the Cardiovascular Section, American Physiological Society, 1994-present

Joseph P. Gilmore, Ph.D. Distinguished Basic Scientist Award, University of Nebraska College of

Medicine, Omaha, 1993

Graduate Faculty Fellow, Graduate College, University of Nebraska, Omaha, 1990 - present

Award for outstanding small group instruction, University of Califomia, San Francisco, 1988

Established Investigator, American Heart Association, 1990 - 1995

NRSA Trainee in Heart and Vascular Diseases, 1982 - 1985

NIH Trainee in Systems and Integrative Biology, 1975 - 1978

Who's Who in American Colleges, 1972

James Scholar, Phi Beta Kappa, University of Illinois, 1972 - 1974

Professional Organizations

The Physiology Society, UK (2011- present)

American Physiological Society (1980 - present) (Fellow)

Neural Control and Autonomic Regulation (Primary affiliation)

Cardiovascular (Fellow)

Respiration

Nebraska Physiological Society (1998-present)

American Heart Association (1980 - present)

Basic Science Council

Circulation Council (Fellow)

Hypertension Council

American Autonomic Society (2013- present)

International Society of Autonmic Neuroscience (2015- present)

American Thoracic Society (2015- present)

Society for Free Radical Biology & Medicine (2010-present)

American Heart Association, Midwest Affiliate (1999- present)

American Heart Association, Nebraska Affiliate (1990 - 1999)

International Association of Medical Science Educators (1996-2009)

Phi Beta Kappa (1973 - present)

Phi Theta Kappa (1972 - present)

Phi Kappa Phi (1972 - present)

Sigma Xi (1981 - present)

Professional Service Activities

COMMITTEE ASSIGNMENTS

A. AMERICAN HEART ASSOCIATION

National Peer Review Group, Vascular Biology and Blood Pressure Regulation (2009- present)

Abstract Selection Committee: 68th Scientific Sessions, American Heart Association, 11/95.

Research Committee: Nebraska Affiliate (1992 -1993)

B. NATIONAL INSTITUTES OF HEALTH

NATIONAL HEART, LUNG, AND BLOOD INSTITUTE: Respiratory Integrative Biology and


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Translational Research Study Section (regular member 2011-2015; Ad hoc 2016-present).

Cardiovascular and Respiratory Sciences Integrated Review Group (ad hoc, 2009-2015). Clinical

and Integrative Cardiovascular Sciences (ad hoc 2016-present).

COMMON FUND U18: Stimulating Peripheral Activity to Relieve Condtions (SPARC) peer

review group (July 2015)

C. AMERICAN PHYSIOLOGICAL SOCIETY

President, Nebraska Physiological Society Chapter (2019-2020)

Amercian Physiological Society Task Force on Conferences (2017)

Councilor, Amercian Physiological Society (2016-2019)

Council Liason to the Animal Care and Experimentation Committee, APS (2016-2019)

Beverly Petterson Bishop Award for Excellence in Neuroscience Committee (2014-2017)

Chairman, Neural Control Autonomic Regulation Section, APS (2012-2015)

Section Advisory Committee member, APS (2012-2015)

Nominated Chair, Chapter Advisory Committee, APS (2013)

Secretary/Treasurer, Neural Control Autonomic Regulation, APS (2009-2012)

Chapter Advisory Committee member, APS (2008- 2011)

President, Nebraska Physiological Society Chapter (2006-2007)

President Elect, Nebraska Physiological Society Chapter (2005-2006)

Secretary-Treasurer, Nebraska Physiological Society Chapter (2004-2006)

Councilor, Nebraska Physiological Society Chapter (2002-2004)

D. INTERNATIONAL SOCIETY of ARTERIAL CHEMORECPTION

XXth Meeting of the International Society of Arterial Chemoreception (ISAC)

Organizing committee chair, ISAC XX 2017, July 23-27, 2017, Baltimore, MD

E. AMERICAN AUTONOMIC SOCIETY

APS Advisory Liason to Board of Directors (2013-2014)

F. UNlVERSITY OF NEBRASKA MEDICAL CENTER

Comparative Medicine Advisory Group, UNMC, (2007-present)

Co-Chairman, Teaching, Learning, and Technology Round Table, UNMC, (1999-2003)

UNMC Honors Program Development Committee and Honors Program Research-Track

Subcommittee, representative of the College of Medicine, (1999-2000)

"UNMC Research in the 21st Century", UNMC retreat, 1999

Lied Space Ad Hoc Committee, Reviewed proposals for faculty applications to occupy College of

Medicine research space in the Lied Transplant Center. (1998)

Learning Environment Task Force (1995-1997). Chair: Edwin Rejda

Cluster Review Work Group. Chair: Dr. Harold Schultz

Faculty Development Center Work Group. Chair: Dr. James Newland

G. UNIVERSITY OF NEBRASKA COLLEGE OF MEDICINE

Co-director, Respiratory Block, Phase 1, Training Physicians of Tomorrow Medical Curriculum,

University of Nebraska College of Medicine, (2016- present)

Member Pulmonary Teaching Circle in the College of Medicine, a bi-weekly small group

discussion of educational activities related to pulmonary medicine (1997—present)


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Scholastic Evaluation Committee (1993-1999) Chair: Dr. Harold Schultz

LCME Self Study Task Force, Review of student evaluation procedures. (1998)

Curriculum Committee Task Force for Vertical Integration of Cardiovascular Sciences (1997)

COM Task Force on revising student advisor system.

College of Medicine Strategic Planning Committee (1993). Chair: Dr. Rodney Markin.

Informatics Subcommittee Vice-chairman: Dr. Harold Schultz

Curriculum Subcommittee (1991-1992). Chair: Dr. Gerald Moore.

Participated in Phase 1a and 1b in the development of the new curriculum for the College of

Medicine.

COM Curriculum retreat(1995) Chair: Dr. James Linder.

Participated in subcommittee to evaluate "The role of technology in the curriculum, and

curricular content for the future practice environment". Subcommittee chair: Dr. Thomas Lynch

H. DEPARTMENT OF CELLULAR & INTEGRATIVE PHYSIOLOGY

Search Committee, C&I Physiology Department faculty position (2012) Chair: H. Schultz

Promotion and Tenure Committee, (2006- present)

Outstanding Performance Committee (2007-2009)

Search Committee (2005) Chair: Kaushik Patel

Graduate Committee (1995 - 2003) Chair: George Rozanski

Search Committee (1995) Chair: H. Schultz

PEER REVIEW OF PUBLICATIONS

Senior Editor (Cardiovacular-Respiratory), The Journal of Physiology (2016-present)

Senior Editor The Journal of Physiology special edition: Advances in cellular and integrative

control of oxygen and carbon dioxide homeostasis (2018)

Senior Editor The Journal of Physiology special edition: Pulmonary Vascular Function in Health

and Disease (2018)

Reviewing Editor, The Journal of Physiology (2011-2016)

Editorial Board, American Journal Of Physiology: Heart and Circulatory Physiology (2009-

present)

Editorial Board, American Journal of Physiology: Regulatory, Integrative, and Comparative

Physiology (2009-present)

ad hoc, Nature

ad hoc, Neuroscience Letters

ad hoc, Cardiovascular Research

ad hoc, Circulation Research

ad hoc, Hypertension

ad hoc, Journal of Applied Physiology

ad hoc, Respiratory Physiology and Neurobiology

ad hoc, Experimental Physiology

ad hoc, The FASEB Letters

ad hoc, European Journal of Physiology

ad hoc, other misc journal


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PEER REVIEW OF GRANTS

Active

National Heart, Lung, and Blood Institute: Clinical and Integrative Cardiovascular Sciences Study

Section (ad hoc 2016- present)

National Heart, Lung, and Blood Institute: Respiratory Integrative Biology and Translational

Research Study Section (regular member Oct 2011- 2015, ad hoc 2016-present);

National Heart, Lung, and Blood Institute: Cardiovascular and Respiratory Sciences Integrated

Review Group (ad hoc, 2009-present)

American Heart Association: Peer Review Study Group; Vascular Biology and Blood Pressure

Regulation 2 (2009- present)

Health Research Council of New Zealand, (2007, 2018)

Completed

National Institute of Health Common Fund U18: Stimulating Peripheral Activity to Relieve

Condtions (SPARC) peer review group (July 2015)

External Advisory Group: 5P01 HL096570-04: Acute and Chronic Affernt Engagement:

Sympathetic and End Organ Responses. Project Leader: Larry Sinoway, MD. Penn State Univ.

Hershey Medical Center

American Heart Association: Peer Review Study Group; Region 4 Cardiac Biology/Regulation 1

(2007- 2009)

National Heart, Lung, and Blood Institute: Program Project Grant Special Review Committee

(5/3/07, 12/11/07)

National Heart, Lung, and Blood Institute: Program Project Grant Special Review Committee

(5/2/07, 1/08/08) (separate grant review from 5/3/07)

Health Research Council of New Zealand, (2007)

Heart & Stroke Foundation of Canada, (2007)

Alberta Heritage Foundation for Medical Research, Alberta, Canada, (2006-2007)

American Heart Association: National, CV Regulation (2000-2002)

American Heart Association: MidAmerica Consortium (1999-2002)

Department of Veterans Affairs: Merit Review (1994-1995, 1999-2002)

National Institute of Health: Experimental Cardiovascular Sciences , Special Study Section (1993)

American Heart Association: Great Plains Consortium (3/12//92 - 3/14/92)

National Heart, Lung, and Blood Institute: Program Project Grant (6/3/91 - 6/5/91)

SCIENTIFIC SESSION CHAIRMAN/MODERATOR

Organized and chair 2 symposium selected for the Pan Amercian Conference May 2019, Havana

Cuba. "Exercise training and cardiovascular autonomic function: friend or foe?" and "Neuroinflammation and autonomic dysfunction in cardio-respiratory diseases"

Organizing symposium chairman for IUPS 38th World Congress 2017 Rio de Janeiro. “Polymodal

Properties of Carotid Body Chemoreceptors Beyond Hypoxia: Relation to Health and Disease”

Organizing co-chairman for XXth Meeting of the International Society of Arterial Chemoreception,

July 2017, Baltimore, MD.

“Automatic nervous system as a therapeutic target in heart failure” Heart Failure Association of the

European Society of Cardiology, Translational Research Committee Workshop on ‘Brussels,

March 2016.

Organizing symposium chairman for Meeting of the International Society for Autonomic

Neuroscience. Stressa, Italy, September 2015. “Targeting Autonomic Imbalance in

Pathophysiology: Is the Carotid Body the New Nirvana?”


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Co-organizer: APS conference “Autonomic Regulation of Cardiovascular Function in Health and

Disease” July 7-10, 2012 Omaha, Nebraska

Organizing symposium chairman for XVIIIth Meeting of the International Society for Arterial

Chemoreception. McMaster University, Hamilton ON, July 2011. “Translational Impact of O2

Sensing"

Co-organizing symposium Beijing Joint Conference of Physiological Sciences, Beijing, China,

October 20, 2008. “Oxygen Sensing: Function and Dysfunction"

Organizer for Combined Meeting of the Iowa and Nebraska Physiological Societies, Master of

Ceremony, Nebraska City, September 9, 2007.

Participant FASEB Summer Conference, Neural Mechanisms in Cardiovascular Regulation, Sydney,

AU. 2007 “Chemoreflex and Sympathetic Activity in Heart Failure Gone Awry”

Participant FASEB Summer Conference, Snowmass Co., 2002. “Mechanisms of sensory

transduction”

“Chemoreflex Control of Cardiovascular Function in Health and Disease”, Featured Topic,

Experimental Biology 2002

Oral Presentations, UNMC Second Cardiovascular Research Symposium 2/13/98

"ATP-dependent K Channels and Myocardial Protection", 68th Scientific Sessions, American

Heart Association, 11/14/95.

"Reflex Effects of Hypoxemia and Ischemia", 65th Scientific Sessions, American Heart

Association,11/18/93.

"Arterial Baroreflexes", Federation of American Societies for Experimental Biology, 4/5/92.

CONTINUING EDUCATION

American Autonomic Society, CME workshops, Big Island, HI, 10/13

Faculty Development Workshop: Speak Easy: What Faculty Need to Know About Lecturing and

Presenting, UNMC, 9-22-2010

Annual Cardiovascular Research Symposium, UNMC, 2/97 – 2/09

Career Development Senior Faculty Institute, UNMC, 3/18/99-3/19/99

Educational Development Institute Basic Teaching Skills,UNMC, 1/21/99-1/22/99.

Educational Development Institute, University of Nebraska Medical Center, 9/10/98-9/11/98.

Mentoring Institute, University of Nebraska Medical Center, 3/12/98-3/13/98



Educational Development workshops, UNMC:

Writing Multiple Choice Questions: 7/8/98

Understanding People: 10/7/98

Copyright Issues: 12/2/98

OTHER PROFESSIONAL SERVICE

Abstract judge, Annual Midwest Student Biomedical Research Forum, Omaha, NE (2010-2017)

Poster judge, Annual Nebraska Physiolgical Society Meeting (annual)

Phun Day Event for American Indian youth, Marina Inn Events Center, Sioux City, NE, 3/ 3/2015

Phun Day Event Faculty participant, APS Phun Week, Omaha, NE, 2012- present

Reviewer, grant application, Diabetes UK, London (2010)

Reviewer, final reports, Health Effects Institute, Boston, MA (2008-2009)

Reviewer, faculty promotion, United Arab Emirates University Medicine and Health Sciences. (2008)


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Reviewer, grant application, Alberta Heritage Foundation for Medical Research, Edmond, Aberta, CA

(2007-2008)

Reviewer, grant application, Catalan Agency for Health Technology Assessment and Research,

Barcelona, Span ( 2007-2008)

Reviewer, grant application, National Health and Medical Research Council, Canberra, AU (2006)

COMMUNITY SERVICE

Fund raising for William Syndrome Association, 2015-present

North High School Pep Club (2008- 2011)

Central High School Pep Club (2004 - 2008)

McMillan Middle School Parent Advisory Board (2006 - 2007)

Dundee/Memorial Park Neighborhood Association, member (1992 - present)

Dundee Presbyterian Church, (1995 - present)

Boy Scouts of America, Troop 365, Den Assistant, 1999-2003

4-H, SOS club, Omaha, group leader, 1999-2000

American Heart Association, Nebraska, volunteer (1990- present)

American Diabetes Association, volunteer (1990 - present)

Alumni Association, University of California, San Francisco, member (1991 - present)

St. Luke's Hospital, Kansas Clty, MO, volunteer (1979 – 1980.


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Teaching Activities

A. LECTURES GIVEN IN TEAM-TAUGHT COURSES

University of Nebraska College of Medicine:

Co-direcotr of Respiratory Block, TPOT College of Medicine curriculum (2016- present).

Lecturer of Respiratory Physiology in Function of the Human Body Core 3 (1992 -present). Nine

to ten hours of lectures presented, yearly, to first year medical students concerning the

physiology of the respiratory system. Topics included: pulmonary circulation, ventilation, lung

mechanics, gas exchange in the lung, ventilation/perfusion inequalities, control of ventilation,

respiratory insufficiencies, high altitude adjustments, pulmonary defense, and acid-base

regulation. Examination format multiple choice/essay.

Organizer and participant of a cardiovascular demonstration in Function of the Human Body Core

(1994 -2005). A cardiovascular demonstration on a chronically instrumented dog presented

during 2 hr sessions to 8 groups of first year medical students. Developed a computer program

to aid in the presentation of the material.

Organizer and participant of a pulmonary demonstration in Function of the Human Body Core

(1997 -present). A two hour demonstration on pulmonary function testing presented to first year

medical students. Developed a computer program to aid in the presentation of the material.

Pulmonary Fellows (2000-2006): Presented a 1 hr lecture to Pulmonary Fellows on neural control

of breathing.

Tutor for Medical Students with academic difficulty (1993- present): Individual instruction to 1- 2

students yearly over respiratory topics presented in lectures. Average 10-20 hrs/year.

Problem-Based Learning Facilitator, student orientation (1992 and 1993). Participated as a group

facilitator for a practice case during new student week. The purpose of the exercise was to

introduce problem based learning techniques to the freshmen students.

University of Nebraska College of Allied Health Sciences:

Perfusionist course (2003-2004): Presented a 4 hr lecture to perfusionist students on principals of

gas exchange.

University of Nebraska Redox Biology Center, Lincoln, NE:

Redox Regulation, Oxidative Stress and Selenoproteins: graduate course 2214 (2009): Presented a

one hour lecture on cellular mechanisms of oxygen sensing.

Department of Cellular & Integrative Physiology, University of Nebraska College of Medicine:

Lecturer of Respiratory Physiology in Physiology 306/806 (1999-present). Nine to ten hours of

lectures presented, yearly, to graduate, PT, and PA students concerning the physiology of the


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respiratory system. Topics included: pulmonary circulation, ventilation, lung mechanics, gas

exchange in the lung, ventilation/perfusion inequalities, control of ventilation, respiratory

insufficiencies, high altitude adjustments, pulmonary defense, and acid-base regulation.

Examination format was multiple choice.

Oversight over student-facilitated group discussion (one-two topics) for recitaiton course for

Physiology graduate students as part of the IPMM 916 course. (2011- present)

Guest Lecturer Cardiopulmonary Function in Health and Disease 916 (2011-2013). One hr lecture

on neural control of breathing, and fascilitaed student lead journal article discussion

Guest Lecturer Redox Biology in Human Disease 922 (2010). One hr lecture on reactive nitrogen

species, and fascilitaed student lead journal article discussion.

Tutor for 806 Students with academic difficulty (1993- present): Individual instruction to 1- 2

students yearly over respiratory topics presented in lectures. Average 10-20 hrs/year.

Lecturer of Respiratory Physiology in Physiology 810 (1992-1994). Eight to seventeen hours of

lectures were presented, yearly, to graduate students (4 to 15 per class) concerning the

physiology of the respiratory system. Topics included: pulmonary circulation, ventilation, lung

mechanics, gas exchange in the lung, ventilation/perfusion inequalities, control of ventilation,

respiratory insufficiencies, high altitude adjustments, pulmonary defense, and acid-base

regulation. Examination format was multiple choice and essay.

Lecturer of Respiratory Physiology in Human Physiology 510 (1991- 1992). Twelve to fourteen

hours of lectures were presented, yearly, to freshmen medical students (125 - 137) concerning

the physiology of the respiratory system. Topics included: functions of the lung, pulmonary

circulation, ventilation, lung mechanics, gas exchange in the lung, control of

ventilation,respiratory insufficiencies, high altitude adjustments, pulmonary defense, and acid-

base regulation. Examination formats included multiple choice, short answer, and essay.

B. COURSE ORGANIZER/SUPERVISOR

Director of Scientific Writing CIP/PHAR 817 (2016-present)(Co-director 2011-2014). Direct a 16

week course (1 hours/wk class time), twice per year, in the art of scientific writing for graduate

students. Students interact weekly in small groups on writing their manuscripts. Graded weekly

homework assignments.

Director of Scientific Writing CIP/PHAR 814 (2015-present)(Co-director 2011-2014). Direct a 16

week course (1 hours/wk class time), twice per year, in the art of scientific writing for graduate

students. Presented 8 hrs of lecture. Lecture based course on best particies on writing a scientific

mansucript for journal publication. Weekly homework assignments are given.

Co-director of Advanced Cardiopulmonary Physiology 916 (2005 - 2009). Co-direct a 16 week

course (2 hours/wk class time), every other year, in advanced topics in cardiopulmonary

physiology for graduate students. Presented 4 hrs of lecture. Students were graded weekly on

journal presentations and on 2 formal debates.


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Co-director of Function of the Human Body Core (1992 - 1994)1 Assistant Director (1996 - 1999).

A 10 week course in integrated physiology, biochemistry, histology, and nutrition of the human

body for freshmen medical students. Responsibilities as Core Director were shared with Dr.

Margaret Heidrick from the Department of Biochemistry and Molecular Biology.

Responsibilities were: coordination of lectures, problem-based-learning cases, laboratories, and

help sessions for the basic science section of the Core. Forty-six faculty from 14 different basic

science and clinical departments participate in the course as lecturers, lab instructors, and PBL

facilitators. Duties included determination of schedules, lecturers, topics, examination

formats,and evaluation procedures for the course, and implementation of summer remediation

for the core.

Coauthor of Problem-Based-Learning Case, Armen Hammer, for Function of the Human Body

Core (1993). A clinical case study was developed that emphasized the physiology of acid/base

and fluid volume regulation. The authors provided the students with a detailed case summary

and classroom review at the end of the case.

Coauthor of Problem-Based-Learning Case, Ralph Sneider, for Function of the Human Body Core

(1998). A clinical case study was developed that emphasized the physiology of acid/base and

fluid volume regulation. The authors provided the students with a detailed case summary and

classroom review at the end of the case.

C. COURSES TAUGHT AS SOLE INSTRUCTOR

Lecturer of Advanced Respiratory Physiology 918 for graduate students (Spring 1991, Fall 1995,

Spring 1997, Fall 1999, Fall 2002). Lectured a 16 week course (2 hours/wk) in advanced topics

in respiratory physiology (neural control of respiratory function) for graduate students. Four

group discussions were led by the students who selected individual topics. A research paper was

required as the examination.

D. GRADUATE/POSTDOCTORAL ADVISOR

Post-doctoral advisor for Nikolay Karpuk, (2018-present). Position started March 1, 2018.

Post-doctoral advisor for Bryan Hackfort, (2017-2017). Position started April 2017. Promoted to

director of ultrsound imaging core at UNMC in October 2017

Post-doctoral advisor for Robert Lewis, (2016-2018). Position started April 2016. Obtained a

position in undergraduate teaching in April 2018.

Post-doctoral advisor for Noah Marcus, (2010-2015). Noah Marcus received a postdoctoral

fellowship from the American Heart Association and a National Research Science Award to

study the role of chemoreflex function in Cheyne-Stokes breathing in heart failure.

Post-doctoral advisor for Rodrigo Del Rio, (2011-2013). Rodrigo submitted an AHA fellowship

application that narrowly missed funding. In teh process of resubmitting, he obtained a faculty

postion at the Universidad Autónoma de Chile, Santiago, Chile. He is studying autonomic

abnormalities in heart failure and hypertension.

Post-doctoral advisor for Drs. Aijie Huang (2010). Dr. Huang was not productive in the lab and

decided to move to another area of study.

Post-doctoral advisor for Dr. Yan Feng Ding (2005 - 2009). Dr. Ding received a postdoctoral

fellowship from the American Heart Association to influence of reduced carotid body blood flow

on chemorelfex function in heart failure. He is now an Instructor at Univeristy of Texas.


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Post-doctoral advisor for Dr. Nermien Waly (2005 - 2006).

Post-doctoral advisor for Dr. Yu-Long Li (2002 - 2004) and mentor as junior faculty member in

the Depart. C&I Physiology, UNMC. Dr. Li submitted a Scientific Development Grant from the

American Heart Association to study hyperpolarizing cation (HCN) channel function in aortic

baroreceptors in diabetic rats. He is now an Assistant Professor in the Depart. of Emergency

Medicine, UNMC.

Post-doctoral advisor for Dr. Maram K. Reddy (2001 - 2003). Dr. Reddy submitted a postdoctoral

fellowship to the American Heart Association to study CNS pathways of chemoreflex function

in heart failure. He returned to India with a research position in the India miliatry.

Post-doctoral advisor for Dr. Yong-Chun Zeng (2000 - 2005). Dr. Zeng received a postdoctoral

fellowship from the American Heart Association to study ion channel function in cardiac sensory

neurons in heart failure and diabetes. He advanced to another post-doc at Mayo Clinic.

Post-doctoral advisor for Dr. Xia-Hong Xia (1999 - 2004). Dr. Xia received a postdoctoral

fellowship from the American Heart Association to study the function of chemoreflex function

in heart failure. She became director of research in univerity in Beijing China.

Post-doctoral advisor for Dr. Shu-Yu Sun (1996 - 1999). Dr. Sun received a new investigator

award from the American Heart Association to study the function of chemoreceptor afferent

nerve endings in heart failure. He is now senior research admnistrator for Merck.

Post-doctoral advisor for Dr. Carolyn Barrett (1997 - 1999). Dr. Barrett was awarded a

postdoctoral fellowship from the American Heart Association to study the function of cardiac

chemoreceptor afferent nerve endings in diabete. She is now Associate Professor at Ackland

University in New Zealand.

Post-doctoral advisor for Dr. Elena Ustinova (1991 - 1995). Dr. Ustinova received a postdoctoral

fellowship from the American Heart Association, and a National Research Service Award from

theNational Institute of Health to study the function of cardiac afferent nerve endings in

myocardial ischemia. Dr. Ustinova was selected as one of five finalists for the Melvin Marcus

Award in Integrative Physiology, sponsored by the American Heart Association, 1993. She

became inactive to advance spouse career.

Predoctoral advisor for Margaret Hicken (1993 - 1995). Ms. Hicken was enrolled in the Masters

Program in the Department of Biology at the University of Nebraska, Omaha. Ms.Hicken's thesis

project addressed the effect of natriuretic peptides on cardiopulmonary reflexes. Current status

unknown.

Summer Research advisor for undergraduate students: I have supervised summer research projects

for 9 students to date: Nicholas Jesse (2015), Bradley Hall (2011), John Majerus (1995), and

Jeff Nienaber (1999) who received medical student summer research fellowships; Richard

Akromis, Katherine Palmisano (2007); Chad Agnew (2005), Ozgur Ozkan (1991 - 1992), Kai

Wilken (1993), and William Nienaber (1999) who were sponsored by the UNMC Summer

Research Program; Navasha McGlothan (1993-94) and Dusty Friedman (1997) who obtained a

Summer Research Fellowship from the American Heart Association, Nebraska Affiliate)

Supervisory Committee, UNMC Graduate College:

Peter Pellegrino, M.D Ph.D. College of Medicine, 2013- present

Andrew Gard, College of Medicine, M.D. Honors Thesis Review, 2009


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Allison Kleiber, Department of Cellular & Integrative Physiology, obtained 2008

Jun-Li Liu, Department of Physiology and Biophysics, Ph.D. obtained 1999

Ma Rong, Department of Physiology and Biophysics, Ph.D. obtained 1999

E. PREVIOUS TEACHING EXPERIENCE

Department of Physiology, University of California, San Francisco. CA.

Conference leader and laboratory instructor for Physiology 100 (1987 -1990). Leader of

smallgroup discussions two hours/week for a II week course on the physiology of the

cardiovascular,respiratory, and renal systems for year 1 medical students (125 students/class).

The conferences were devoted to practice in solving physiological problems. Instructed

laboratory exercises (3 hrs each) on ECG, Wigger's diagram, control of breathing, and renal

function labs in humans, and a lab on cardiovascular events and drugs in dogs. Other

responsibilities included writing and grading exam questions on lecture and laboratory material.

Coauthor of a Computer-Aided Instruction Program, HyperCardiac (1990). Working with

Dr.Goerke, we developed three Hypercard-based computer applications for the Macintosh

computer. These animated teaching tools combine recordings of actual heart sounds with

dynamics visual effects to illustrate the time relationships of the events and phases of the cardiac

cycle. The applications are provided as freeware to medical students and are available on

BITNET and at the Sievers Facility in the McGoogan Library, UNMC.

Laboratory instructor for Physiology 125 (1986-1990). Instructed laboratory exercises (3 hrs each)

on ECG, Wigger's diagram, control of breathing for Pharmacy students (120/class average).

Lecturer of Advanced Cardiovascular Physiology 221 for graduate students (1989). Provided a

guest lecture (2 hours) on neural control of the circulation and baroreceptor reflex function for

Physiology graduates students.

Department of Physiology, University of California. Berkeley, CA.

Lecturer of cardiovascular physiology for Physiology 100 (1988). Provided five lectures an

examination on principles of hemodynamics and cardiovascular regulation for an undergraduate

course in human physiology (150 students).

Department of Physiology, University of Kansas. Kansas City, KS.

Laboratory instructor of a cardiovascular events laboratory in dogs (3 hours) for medical students

(1980).

Webster College of Baccalaureate Nursing, St. Luke's Hospital, Kansas City, MO.

Course director and instructor of pathophysiology for nursing students. Directed and lectured (36

lecture hours) a twelve week comprehensive course in pathophysiology for nursing (1981).


14

Research Activities

GRANT AWARDS

A. PRINCIPAL INVESTIGATOR

Active Principle Investigator

2 P01 HL062222-16 Zucker- PD (H.D. Schultz PI of Project III) 9/01/15-07/31/20

DHHS/NIH/NHLBI

Neuro-Circulatory Function in Chronic Heart Failure

To understand the interaction between neurohumoral substances and the regulation of sympathetic

activity in animal models of chronic heart failure (CHF). Experiments are carried out in three

projects and three cores. These studies evaluate baroreflex, chemoreflex and cardiopulmonary

reflexes, the roles of angiotensin II and nitric oxide on the sympatho-excitatory process in CHF.

Role: Project Leader for Project III and Co-Investigator on Project I and II.

1R01HL124992-01 (Schultz) 7/01/14

Carotid Body in Pathophysiology of Heart Failure: Afferent-Efferent Mechanisms

DHHS/NIH/NHLBI

The proposed studies are designed to determine to the role of the carotid body chemoreflex on

sympathetic and ventilator function in two models of chronic heart failure contrasted by differences in

systemic blood flow. Funded but administratively converted to R56.

Role: Principal Investigator

1R56HL124992-01 (Schultz) 09/01/14-08/31/15

Carotid Body in Pathophysiology of Heart Failure: Afferent-Efferent Mechanisms

DHHS/NIH/NHLBI

The proposed studies are designed to determine to the role of the carotid body chemoreflex on

sympathetic and ventilator function in two models of chronic heart failure contrasted by differences in

systemic blood flow. This funded R56 was rolled over into the PPG above.


16CSA28580000 (Schultz) 07/01/16 - 06/30/19

American Heart Association - National

Exploring the Neurological Basis of Dyspnea and its Impact on Exercise Intolerance in Heart Failure

To identify regions of the human brain that are activated by dyspnea induced by specific sensations

and by exercise using noninvasive brain imaging; 2) to determine if differences exist in the intensity

and patterns of neural activity between heart failure (HF) and healthy subjects. 3) to explore the

cellular basis of exaggerated dyspnea in HF rats and test if it can be reversed to improve function and

exercise ability in HF.


Pending PI Grants

1 R21 AR072140-01 (Gao/Schultz ) 10/20/16-6/30/19

DHHS/NIH/NIAMS

Pending resubmission: Exercise Intolerance in Chronic Heart Failure and Skeletal Muscle Nrf2


15

The proposed studeis are designed to deteminr the role of altered Nrf2 control of antioxdant pathways

in skeletal muscle in heart failure mice and its contribution to impaired exercise capacity.

Role of Project: Co-Principal Investigator

1 R01 AR073812 9 (Gao/Schultz) 09/01/2018 - 08/31/2023

Pending resubmission: Keap1-Nrf2 signaling in skeletal muscle in Chronic Heart Failure

The proposed studeis are designed to deteminr the role of altered Nrf2 control of antioxdant pathways

in skeletal muscle in heart failure mice and its contribution to impaired exercise capacity.

Role of Project: Co-Principal Investigator

Previous PI Grants

1R01HL124992-01 7/01/14- Carotid Body in Pathophysiology of Heart Failure: Afferent-Efferent

Mechanisms $1,879,865 (direct costs). Score 26 (13%). Converted to R56 HL124992-01.

R01 HL096755-01. 7/1/2009-6/30/14, Role of Blood Flow on Carotiod Chemoreflex Dysfunction in

Heart Failure. $1,752,079. Score: 137 (9.5%) Relinquished to allow funding of duplicate grant

PO1 HL062222

Coridea NCI, 1/3/2012-1/1/2013, Therapeutic Efficacy of Carotid Body Denervation in Progression

of Heart Failure. $113,000.

PO1 HL062222-06, 7/1/99 to 6/30/09, Neuro-Circulatory function in chronic heart failure: Project 3:

Chemoreflex function in heart failure. National Heart, Lung, and Blood Institute. $846,467. Score:

150.

PO1 HL062222-01, 7/1/99 to 6/30/09, Neuro-Circulatory function in chronic heart failure: Project 4:

Enhanced cardiac sympathetic afferent reflex in heart failure. (Co-Investigator) National Heart,

Lung, and Blood Institute. $846,467.

UNL Redox Biology Grant: 3/1/04-3/1/06, O2 Sensing in the Carotid Body: In Search of a Membrane

Hemoproteic Sensor That Modulates K+ Channel Function.$50,000.

R01 HL52190-01A2 ,7/1/95 to 6/30/00, Cardiac afferents, free radicals, and ischemia. National Heart,

Lung, and Blood Institute. $583,864. Score: 128

R01 HL54586-01, 7/1/95 to 6/30/00, Role of neuropeptides in protection of the myocardium.

Individual Research Award, National Heart, Lung, and Blood Institute. $323,644. Score: 150

American Heart Association Grant-in-Aid Award, Mechanism of lmpaired Cardiac Chemoreflex

Function in Diabetes 1/1/00- 12/31/02 no cost extension 12/31/03

Indirect Cost Award, 4/1/2001-3/30/2003, Ion Channels in Diabetic Complications. Univeristy of

Nebraska College of Medicine $24,000.

Grant-in-Aid, American Heart Association, National. Mechanisms of impaired cardiac chemoreflex

function in diabetes. $214,500. Score 13'th percentile.

Grant-in-Aid, 8/1/97 to 7/31/99, Enhanced Chemoreflex Function in Heart Failure: Role of Central

Angiotensin II, American Heart Association, Nebraska Affiliate. $40,000.

UNMC traditional seed grant, 7/1/98 to 6/30/99.Mechanisms of altered carotid body function in heart

failure. $15,000.

Educational grant. College of Medicine, 1999, UNMC. $2500.

Educational grant. College of Medicine, 1997, UNMC. $2500.

Grant-in-Aid Award, 7/1/95 to 6/30/97 Cardiac afferents, free radicals, and ischemia. American

Heart Association, Nebraska Affiliate. $40,000. Score: 1.5 Relinquished due to overlap.

Nebraska Banker's Association, Small equipment application for Radiometer blood gas analyzer

$9780.

Grant-in-Aid Award (7/1/92 - 6/30/95), American Heart Association, National. Afferent and reflex


16

properties of arterial C-fiber endings.

Grant-in-Aid Award (7/1/92 - 7/1/94), American Heart Association, Nebraska Affiliate. Effect of

atrial natriuretic peptide on sensory endings with vagal afferents.

UNMC seed grant (7/1/93 - 6/30/94). Cardiac Afferent Responses During Myocardial Ischemia and

Reperfusion: Role of Free Radicals.

Nebraska Public Health Service Award (7/1/90-6/30/92). Reflex control of airway secretion in lung

disease.

Individual Research Award (4/1/89-3/31/93), National Heart, Lung, and Blood Institute C-fiber

baroreceptors: Afferent and reflex properties.

Established Investigator Award (7/1/89-6/30/94), American Heart Association, National . Afferent

and reflex properties of carotid C-fiber endings.

Grant-in-Aid Award (7/1/89-6/30/92), American Heart Association, National. Afferent and reflex

properties of carotid C-fiber endings. Awarded and declined due to alternative funding.

Instructional Use of Computers Award (7/1/88-6/30/89), University of California, San Francisco.

Teaching dynamic physiological systems on the Macintosh computer.

Instructional Improvement Grant (8/1/88-7/30/89), University of California, San Francisco .

Echocardiography meets the Wigger's diagram: Illustrating form and function of the heart in the

classroom.

Grant-in-Aid Award (7/1/86 - 7/1/89), American Heart Association, California Affiliate . Afferent

and reflex properties of C-fiber baroreceptors.

New Investigator Research Award (5/1/85 - 5/1/88). National Heart, Lung, and Blood Institute.

Afferent and reflex properties of arterial C-fibers.

University of California, San Francisco Research Evaluation and Allocation Award (8/1/85 –

3/30/87). Function of C-fiber baroreceptors in the carotid sinus.

Grant-in-Aid Award (7/1/80 - 7/1/81), American Heart Association, Missouri Affiliate . Effect of

angiotensin on the baroreceptor reflex.

B. COINVESTIGATOR

Active Co-Investigator

1OT2OD023848-01 University of California - Los Angeles Subcontract (Zucker) 10/01/16 -

09/30/19

National Institutes of Health

Mapping of cardiac spinal afferents to dorsal root ganglia

The proposed mechanistic research studies will provide much needed knowledge about the anatomy

and function of the nerves that control the heart. These studies can have an immediate clinical impact,

by guiding treatments to reduce mortality by controlling life threatening abnormal heart rhythms, and

improving quality of life for patients with heart failure by preventing the progression of heart disease

and reducing hospitalization.

Role of Project: Co-Investigator

Pending Co-Investigator

Previous Coinvestigator Grants

R56 HLK124104-01 09/01/14-08/31/15 Role of HIF-1 alpha and Renal afferents in Activation of the

PVN in Heart Failure. DHHS/NIH/NHLBI K. Patel, P.I.


17

R01 HL098503-01A1. 07/01/10 to 06/30/15, Dysfunction of Baroreceptor Neurons in Heart Failure:

Cellular and Molecular Mechanisms. DHHS/NIH/NHLBI. Y.L. Li P.I.

R01 HL103942-03. 07/01/10 to 06/30/15, Mitochondrial Redox Systems in Neurogenic Hypertension.

DHHS/NIH/NHLBI. M. Zimmerman P.I.

1F32HL108592-01A1 (Marcus) 07/01/12-06/30/15 Peripheral Chemoreflex Hypersensitivity and

Periodic Breathing in Heart Failure. DHHS/NIH/NHLBI Role: Sponsor

UNMC Free Radicals in Medicine Program (FRMP) pilot project. 07/01/13 to 6/30/15, Free Radical

Biology and Ventricular Assist Devices. Brian D. Lowes, P.I.

Sova Pharmaceuticals, Inc. 1/6/2012-3/31/2012, Pharmacologic Modulation of Peripheral

Chemosensitivity and Ventilation in a Rat Heart Failure Model. $14,489.

American Heart Association Scientist Development Grant, 0930204N. 01/01/2009 – 12/31/2012,

(consultant) Role of superoxide vs. hydrogen peroxide in the redox regulation of angiotensin II-

induced sympathoexcitation. M. Zimmerman P.I.

Individual Research Award, 6/1/92 to 5/31/99, National Heart, Lung, and Blood Institute.

Cardiopulmonary reflexes in congestive heart failure. Irving H. Zucker, Ph.D., Principal

Investigator, $159,590.

Indirect Cost Award, 6/1/97 to 6/30/99, Role of nitric oxide on the neural control of circulation during

heart failure. College of Medicine Irving H. Zucker, Ph.D., Program Director. $17,000.

UNMC traditional seed grant 7/1/97 to 6/30/98. Effectiveness of Percutaneous Transtracheal

Ventilation in the Canine Model of Experimental Asthma Paul T. Tran, M.D., Principal

Investigator $14,774.

UNMC Interactive Seed Grant. The Role of Nitric Oxide and Angiotensin II on the Neural Control of

the Circulation in Heart Failure. Project I. $10,913. Nebraska Public Health Service Award, 7/1/95

to 6/30/96.Effect of nicotine on cardiac vagal afferents during ischemia/reperfusion $48,315. Score:

2.0

Program Project Participant (7/1/89-6/30/90), National Heart, Lung, and Blood Institute.

Myocardial Ischemia. University of California, San Fransciso.

B. SPONSORING INVESTIGATOR (FELLOWSHIP PRIMARY MENTOR)

Summer Research Program (6/1/2018 - 8/1/2018), University of Nebraska College of Medicine

Summer research stipend for undergraduate students. Wenxian Zhou

Summer Research Program (6/1/2017 - 8/1/2017), University of Nebraska College of Medicine

Summer research stipend for undergraduate students. Wenxian Zhou

Medical Student Research Fellowship (6/17 - 8/17), University of Nebraska College of

Medicine. Identify the Neuro-anatomical Basis of Heightened Dyspnea Sensation in Humans with

Chronic Heart Failure and How this Changes with Exercise. Benadette Ngamelue

Medical Student Research Fellowship (6/15 - 8/15), University of Nebraska College of

Medicine. Vetilatory Efficieny in LVAD Patients. Nicholas Jesse, recipient.

National Research Science Award. Role of Altered Chemoreflex Function on Cheyne-Stokes

Respiration in Heart Failure. Fellowship application for Dr. Noah Marcus.

Postdoctoral Fellowship, American Heart Association. Role of Altered Chemoreflex Function on

Cheyne-Stokes Respiration in Heart Failure. Fellowship application for Dr. Noah Marcus.

Scientific Development Award, American Heart Association. Role of HCN channels in blunted

excitability of baroreceptor neurons in diabetes and potential signaling pathways. Dr. Yu Li.

Postdoctoral Fellowship, American Heart Association. Does Reduced Blood Flow Trigger Peripheral

Chemoreflex Hypersensitivity in Chronic Heart Failure Rabbits? Fellowship application for Dr.

Yanfeng Ding.


18

Medical Student Research Fellowship (6/1/07 - 8/30/07), University of Nebraska College of

Medicine. HIF1alpha in the carotid body in heart failure. Chad Agnew, recipient.

Summer Research Program (6/1/07 - 8/1/07), BRIN Scholar Summer research stipend for

undergraduate students. Katie Langenfeld

Summer Research Program (6/1/07 - 8/1/07), University of Nebraska College of Medicine Summer

research stipend for undergraduate students. Richard Akromis


research stipend for undergraduate students. Chad Agnew

Postdoctoral Fellowship, American Heart Association, Ion Channel Function of cardiac Afferent

Neurons in Diabetes. Fellowship application for Dr. Yong Chun Zheng.

New Investigator Award, American Heart Association, Nebraska Affiliate. Effect of Exercise

Training on Chemoreflex Function in Heart Failure: Role of Nitric Oxide. application for Dr.

Shu-Yu Sun, $34,978.

Predoctoral Fellowship, American Heart Association, Nebraska Affiliate, Cardiac Afferent

Function in Diabetes: The Role of the Polyol Pathway. Fellowship for Yi-Ming Zhang, $36,000.

Postdoctoral Fellowship, American Heart Association, Nebraska Affiliate, Role of Carotid Body

Chemoreceptors on Cheyne-Stokes Respiration in Heart Failure. Fellowship application for Dr.

Xiao-Hong Xia, $56,000.

Postdoctoral Fellowship, American Heart Association, Nebraska Affiliate, Cardiac Afferent

Function in Diabetes: The Role of the Polyol Pathway. Fellowship application for Dr. Carolyn

Barrett, $20,000.

Postdoctoral Fellowship, American Heart Association, Nebraska Affiliate. Effect of Exercise

Training on Chemoreflex Function in heart Failure: role of Nitric Oxide. Fellowship application

for Dr. Shu-Yu Sun, $20,000.

Postdoctoral Fellowship, American Heart Association, Nebraska Affiliate. Does Oxidative Stress

Result in Irreversible Damage to cardiac Afferents In Diabetes mellitus ? Fellowship application

for Dr. Carolyn Barrett, $20,000.

Postdoctoral Fellowship (7/1/97 - 6/30/98), American Heart Association, Nebraska Affiliate.

Enhanced Peripheral Chemoreceptor Function in Heart Failure: Role of Nitric Oxide Fellowship

application for Dr. Shu-Yu Sun, $20,000.

Student Research Fellowship (6/1/97 - 8/30/97), American Heart Association, Nebraska Affiliate.

Role of nitric oxide in enhanced chemoreflex sensitivity in heart failure. Dustin Friedman.

National Research Service Award (7/1/93 - 7/1/96), National lnstitute of Health. Function of Cardiac

afferents in postischemia. Elena Ustinova, recipient.*

Medical Student Research Fellowship (6/1/95 - 9/21/95), University of Nebraska College of Medicine.

Protective effect of CGRP on the ischemic myocardium. John P. Majerus.


research stipend for undergraduate students. Ozgur Oskan, Kai Wilken, Navasha McGlothan

recipients.

Student Research Fellowship (6/1/93 - 8/30/93), American Heart Association, Nebraska Affiliate. Do

the Natriuretic Peptides Inhibit Sympathetic Outflow by Activating Cardiac Chemosensitive Nerve

Endings? Kai Wilken, recipient (relinquished with acceptance of UNMC award).

Medical Student Research Fellowship (6/1/93 - 8/30/93), University of Nebraska College of

Medicine. Effects of Cardiac Autonomic neuropathy on Cardiac Dysfunction. Ozgur Ozkan,

recipient.

Postdoctoral Fellowship (7/1/92 - 7/1/93), American Heart Association, Nebraska Affiliate.Cardiac

afferent responses during myocardial ischemia and reperfusion: role of free radicals. Elena

Ustinova, recipient.


19

PUBLICATIONS

A. DOCTORAL THESIS

"An analysis of carotid sinus baroreceptor control of renin release". Department of Physiology and

Biophysics, University of lllinois, Urbana, Illinois, July, 1979.

B. ARTICLES

1. Zehr, JE, Kurz, KD, Seymour, AA and Schultz, HD. Mechanisms controlling renin release. Adv

Exp Med Biol. 130:135-70, 1980. Epub 1980/01/01. PubMed PMID: 6996458.

2. Schultz, HD and Zehr, JE. Alteration of the baroreceptor reflex by an effect of propranolol on the

isolated carotid sinus. J Pharmacol Exp Ther. 216(1):111-7, 1981. Epub 1981/01/01. PubMed PMID:

7452497.

3. Fater, DC, Schultz, HD, Sundet, WD, Mapes, JS and Goetz, KL. Effects of left atrial stretch in

cardiac-denervated and intact conscious dogs. Am J Physiol. 242(6):H1056-64, 1982. Epub

1982/06/01. PubMed PMID: 7091346.

4. Schultz, HD, Fater, DC, Sundet, WD, Geer, PG and Goetz, KL. Reflexes elicited by acute stretch

of atrial vs. pulmonary receptors in conscious dogs. Am J Physiol. 242(6):H1065-76, 1982. Epub

1982/06/01. PubMed PMID: 7046467.

5. Schultz, HD, Zehr, JE and Livnat, A. Central and peripheral adrenergic modulation of carotid

sinus-induced renin release. Am J Physiol. 242(3):R318-25, 1982. Epub 1982/03/01. PubMed

PMID: 7039357.

6. Fater, DC, Sundet, WD, Schultz, HD and Goetz, KL. Arterial baroreceptors have minimal

physiological effects on adrenal medullary secretion. Am J Physiol. 244(2):H194-200, 1983. Epub

1983/02/01. PubMed PMID: 6401939.

7. Green, JF, Schmidt, ND, Schultz, HD, Roberts, AM, Coleridge, HM and Coleridge, JC. Pulmonary

C-fibers evoke both apnea and tachypnea of pulmonary chemoreflex. J Appl Physiol Respir Environ

Exerc Physiol. 57(2):562-7, 1984. Epub 1984/08/01. PubMed PMID: 6469822.

8. Coleridge, HM, Coleridge, JC, Poore, ER, Roberts, AM and Schultz, HD. Aortic wall properties

and baroreceptor behaviour at normal arterial pressure and in acute hypertensive resetting in dogs. J

Physiol. 350:309-26, 1984. Epub 1984/05/01. PubMed PMID: 6747852; PubMed Central PMCID:

PMC1199271.

9. Roberts, AM, Schultz, HD, Green, JF, Armstrong, DJ, Kaufman, MP, Coleridge, HM and

Coleridge, JC. Reflex tracheal contraction evoked in dogs by bronchodilator prostaglandins E2 and

I2. J Appl Physiol. 58(6):1823-31, 1985. Epub 1985/06/01. PubMed PMID: 3891715.

10. Schultz, HD, Roberts, AM, Bratcher, C, Coleridge, HM, Coleridge, JC and Davis, B. Pulmonary

C-fibers reflexly increase secretion by tracheal submucosal glands in dogs. J Appl Physiol.

58(3):907-10, 1985. Epub 1985/03/01. PubMed PMID: 3980392.

11. Roberts, AM, Bhattacharya, J, Schultz, HD, Coleridge, HM and Coleridge, JC. Stimulation of

pulmonary vagal afferent C-fibers by lung edema in dogs. Circ Res. 58(4):512-22, 1986. Epub

1986/04/01. PubMed PMID: 3698217.


20

12. Coleridge, HM, Coleridge, JC, Poore, ER, Roberts, AM and Schultz, HD. Aortic wall creep and

acute baroreceptor resetting. Am J Physiol. 250(1 Pt 2):H149-50, 1986. Epub 1986/01/01. PubMed

PMID: 3942233.

13. Coleridge, HM, Coleridge, JC and Schultz, HD. Characteristics of C fibre baroreceptors in the

carotid sinus of dogs. J Physiol. 394:291-313, 1987. Epub 1987/12/01. PubMed PMID: 3443968;

PubMed Central PMCID: PMC1191962.

14. Schultz, HD, Pisarri, TE, Coleridge, HM and Coleridge, JC. Carotid sinus baroreceptors modulate

tracheal smooth muscle tension in dogs. Circ Res. 60(3):337-45, 1987. Epub 1987/03/01. PubMed

PMID: 3581443.

15. Schultz, HD, Gardner, DG, Deschepper, CF, Coleridge, HM and Coleridge, JC. Vagal C-fiber

blockade abolishes sympathetic inhibition by atrial natriuretic factor. Am J Physiol. 255(1 Pt 2):R6-

13, 1988. Epub 1988/07/01. PubMed PMID: 2969196.

16. Coleridge, HM, Coleridge, JC and Schultz, HD. Afferent pathways involved in reflex regulation

of airway smooth muscle. Pharmacol Ther. 42(1):1-63, 1989. Epub 1989/01/01. PubMed PMID:

2657805.

17. Yu, J, Schultz, HD, Goodman, J, Coleridge, JC, Coleridge, HM and Davis, B. Pulmonary rapidly

adapting receptors reflexly increase airway secretion in dogs. J Appl Physiol. 67(2):682-7, 1989.

Epub 1989/08/01. PubMed PMID: 2793670.

18. Gardner, DG and Schultz, HD. Prostaglandins regulate the synthesis and secretion of the atrial

natriuretic peptide. J Clin Invest. 86(1):52-9, 1990. Epub 1990/07/01. doi: 10.1172/JCI114714.

PubMed PMID: 2142168; PubMed Central PMCID: PMC296689.

19. Rotto, DM, Schultz, HD, Longhurst, JC and Kaufman, MP. Sensitization of group III muscle

afferents to static contraction by arachidonic acid. J Appl Physiol. 68(3):861-7, 1990. Epub

1990/03/01. PubMed PMID: 2111312.

20. Schultz, HD, Steele, MK and Gardner, DG. Central administration of atrial peptide decreases

sympathetic outflow in rats. Am J Physiol. 258(5 Pt 2):R1250-6, 1990. Epub 1990/05/01. PubMed

PMID: 2140027.

21. Rotto, DM, Hill, JM, Schultz, HD and Kaufman, MP. Cyclooxygenase blockade attenuates

responses of group IV muscle afferents to static contraction. Am J Physiol. 259(3 Pt 2):H745-50,

1990. Epub 1990/09/01. PubMed PMID: 2118727.

22. Steele, MK, Gardner, DG, Xie, PL and Schultz, HD. Interactions between ANP and ANG II in

regulating blood pressure and sympathetic outflow. Am J Physiol. 260(6 Pt 2):R1145-51, 1991.

Epub 1991/06/01. PubMed PMID: 1829337.

23. Kovacic-Milivojevic, B, Schultz, HD and Gardner, DG. Arachidonic acid metabolites regulate the

secretion of atrial natriuretic peptide in cultured rat atrial cardiocytes. Can J Physiol Pharmacol.

69(10):1493-9, 1991. Epub 1991/10/01. PubMed PMID: 1723348.

24. Schultz, HD, Davis, B, Coleridge, HM and Coleridge, JC. Cigarette smoke in lungs evokes reflex

increase in tracheal submucosal gland secretion in dogs. J Appl Physiol (1985). 71(3):900-9, 1991.

Epub 1991/09/01. PubMed PMID: 1757327.

25. Ustinova, EE and Schultz, HD. Activation of cardiac vagal afferents in ischemia and reperfusion.

Prostaglandins versus oxygen-derived free radicals. Circ Res. 74(5):904-11, 1994. Epub 1994/05/01.

PubMed PMID: 8156637.


21

26. Ustinova, EE and Schultz, HD. Activation of cardiac vagal afferents by oxygen-derived free

radicals in rats. Circ Res. 74(5):895-903, 1994. Epub 1994/05/01. PubMed PMID: 8156636.

27. Zucker, IH, Wang, W and Schultz, HD. Cardiac receptor activity in heart failure: implications for

the control of sympathetic nervous outflow. Adv Exp Med Biol. 381:109-24, 1995. Epub

1995/01/01. PubMed PMID: 8867828.

28. Ustinova, EE, Bergren, D and Schultz, HD. Neuropeptide depletion impairs postischemic

recovery of the isolated rat heart: role of substance P. Cardiovasc Res. 30(1):55-63, 1995. Epub

1995/07/01. PubMed PMID: 7553724.

29. Zucker, IH, Wang, W, Brandle, M, Schultz, HD and Patel, KP. Neural regulation of sympathetic

nerve activity in heart failure. Prog Cardiovasc Dis. 37(6):397-414, 1995. Epub 1995/05/01. PubMed

PMID: 7777669.

30. Haselton, JR, Reynolds, AY and Schultz, HD. Vagal neuroeffector mechanisms affecting

transpulmonary pressure in the intact rat. J Appl Physiol. 79(4):1233-41, 1995. Epub 1995/10/01.


31. Schultz, HD and Ustinova, EE. Cardiac vagal afferent stimulation by free radicals during

ischaemia and reperfusion. Clin Exp Pharmacol Physiol. 23(8):700-8, 1996. Epub 1996/08/01.


32. Ustinova, EE and Schultz, HD. Renal sympathetic nerve activity during cardiac ischemia and

reperfusion in rats. Am J Physiol. 271(4 Pt 2):R1033-40, 1996. Epub 1996/10/01. PubMed PMID:

8897997.

33. Schultz, HD, Wang, W, Ustinova, EE and Zucker, IH. Enhanced responsiveness of cardiac vagal

chemosensitive endings to bradykinin in heart failure. Am J Physiol. 273(2 Pt 2):R637-45, 1997.

Epub 1997/08/01. PubMed PMID: 9277549.

34. Bergren, DR, Ustinova, EE and Schultz, HD. Pulmonary C-fiber activation before and after

peptidase inhibition in rats. Respir Physiol. 107(2):99-109, 1997. Epub 1997/02/01. PubMed PMID:

9108624.

35. Toews, ML, Ustinova, EE and Schultz, HD. Lysophosphatidic acid enhances contractility of

isolated airway smooth muscle. J Appl Physiol. 83(4):1216-22, 1997. Epub 1997/10/24. PubMed

PMID: 9338431.

36. Tran, TP, Rhee, KJ, Schultz, HD and Carl, ML. Gas exchange and lung mechanics during

percutaneous transtracheal ventilation in an unparalyzed canine model. Acad Emerg Med. 5(4):320-

4, 1998. Epub 1998/04/30. PubMed PMID: 9562195.

37. Schultz, HD and Ustinova, EE. Capsaicin receptors mediate free radical-induced activation of

cardiac afferent endings. Cardiovasc Res. 38(2):348-55, 1998. Epub 1998/08/26. PubMed PMID:

9709395.

38. Sun, SY, Wang, W, Zucker, IH and Schultz, HD. Enhanced activity of carotid body

chemoreceptors in rabbits with heart failure: role of nitric oxide. J Appl Physiol. 86(4):1273-82,

1999. Epub 1999/04/08. PubMed PMID: 10194213.

39. Sun, SY, Wang, W, Zucker, IH and Schultz, HD. Enhanced peripheral chemoreflex function in

conscious rabbits with pacing-induced heart failure. J Appl Physiol. 86(4):1264-72, 1999. Epub

1999/04/08. PubMed PMID: 10194212.


22

40. Wang, W, Schultz, HD and Ma, R. Cardiac sympathetic afferent sensitivity is enhanced in heart

failure. Am J Physiol. 277(2 Pt 2):H812-7, 1999. Epub 1999/08/13. PubMed PMID: 10444509.

41. Barrett, CJ and Schultz, HD. Sympathoinhibitory effects of atrial natriuretic peptide in rats with

heart failure. J Card Fail. 5(4):316-23, 1999. Epub 2000/01/14. PubMed PMID: 10634673.

42. Ma, R, Schultz, HD and Wang, W. Chronic central infusion of ANG II potentiates cardiac

sympathetic afferent reflex in dogs. Am J Physiol. 277(1 Pt 2):H15-22, 1999. Epub 1999/07/17.


43. Schultz, HD and Sun, SY. Chemoreflex function in heart failure. Heart Fail Rev. 5(1):45-56,

2000. Epub 2005/10/18. doi: 10.1023/A:1009846123893. PubMed PMID: 16228915.

44. Ustinova, EE, Barrett, CJ, Sun, SY and Schultz, HD. Oxidative stress impairs cardiac

chemoreflexes in diabetic rats. Am J Physiol Heart Circ Physiol. 279(5):H2176-87, 2000. Epub

2000/10/25. PubMed PMID: 11045951.

45. Wang, W, Schultz, HD and Ma, R. Volume expansion potentiates cardiac sympathetic afferent

reflex in dogs. Am J Physiol Heart Circ Physiol. 280(2):H576-81, 2001. Epub 2001/02/13. PubMed

PMID: 11158954.

46. Sun, SY, Wang, W and Schultz, HD. Activation of cardiac afferents by arachidonic acid: relative

contributions of metabolic pathways. Am J Physiol Heart Circ Physiol. 281(1):H93-H104, 2001.

Epub 2001/06/19. PubMed PMID: 11406473.

47. Schultz, HD. Cardiac vagal chemosensory afferents. Function in pathophysiological states. Ann N

Y Acad Sci. 940:59-73, 2001. Epub 2001/07/19. PubMed PMID: 11458708.

48. Pliquett, RU, Cornish, KG, Patel, KP, Schultz, HD, Peuler, JD and Zucker, IH. Amelioration of

depressed cardiopulmonary reflex control of sympathetic nerve activity by short-term exercise

training in male rabbits with heart failure. J Appl Physiol. 95(5):1883-8, 2003. Epub 2003/07/15.

doi: 10.1152/japplphysiol.00486.2003. PubMed PMID: 12857767.

49. Schultz, HD. The spice of life is at the root of cardiac pain. J Physiol. 551(Pt 2):400, 2003. Epub

2003/07/24. doi: 10.1113/jphysiol.2003.050104. PubMed PMID: 12876213; PubMed Central

PMCID: PMC2343222.

50. Li, YL, Sun, SY, Overholt, JL, Prabhakar, NR, Rozanski, GJ, Zucker, IH and Schultz, HD.

Attenuated outward potassium currents in carotid body glomus cells of heart failure rabbit:

involvement of nitric oxide. J Physiol. 555(Pt 1):219-29, 2004. Epub 2003/12/16. doi:

10.1113/jphysiol.2003.057422. PubMed PMID: 14673183; PubMed Central PMCID: PMC1664828.

51. Zucker, IH, Schultz, HD, Li, YF, Wang, Y, Wang, W and Patel, KP. The origin of sympathetic

outflow in heart failure: the roles of angiotensin II and nitric oxide. Prog Biophys Mol Biol. 84(2-

3):217-32, 2004. Epub 2004/02/11. doi: 10.1016/j.pbiomolbio.2003.11.010. PubMed PMID:

14769437.

52. Zucker, IH, Patel, KP, Schultz, HD, Li, YF, Wang, W and Pliquett, RU. Exercise training and

sympathetic regulation in experimental heart failure. Exerc Sport Sci Rev. 32(3):107-11, 2004. Epub

2004/07/10. PubMed PMID: 15243206.

53. Gao, L, Wang, W, Li, YL, Schultz, HD, Liu, D, Cornish, KG and Zucker, IH. Superoxide

mediates sympathoexcitation in heart failure: roles of angiotensin II and NAD(P)H oxidase. Circ

Res. 95(9):937-44, 2004. Epub 2004/10/02. doi: 10.1161/01.RES.0000146676.04359.64. PubMed

PMID: 15459075.


23

54. Li, YF, Wang, Y, Channon, KM, Schultz, HD, Zucker, IH and Patel, KP. Manipulation of

neuronal nitric oxide synthase within the paraventricular nucleus using adenovirus and antisense

technology. Methods Mol Med. 112:59-79, 2005. Epub 2005/07/13. PubMed PMID: 16010011.

*55. Li, YL, Li, YF, Liu, D, Cornish, KG, Patel, KP, Zucker, IH, . . . Schultz, HD. Gene transfer of

neuronal nitric oxide synthase to carotid body reverses enhanced chemoreceptor function in heart

failure rabbits. Circ Res. 97(3):260-7, 2005. Epub 2005/07/05. doi:

10.1161/01.RES.0000175722.21555.55. PubMed PMID: 15994433.

56. Gao, L, Schultz, HD, Patel, KP, Zucker, IH and Wang, W. Augmented input from cardiac

sympathetic afferents inhibits baroreflex in rats with heart failure. Hypertension. 45(6):1173-81,

2005. Epub 2005/05/18. doi: 10.1161/01.HYP.0000168056.66981.c2. PubMed PMID: 15897358.

57. Gao, L, Wang, W, Li, YL, Schultz, HD, Liu, D, Cornish, KG and Zucker, IH. Sympathoexcitation

by central ANG II: roles for AT1 receptor upregulation and NAD(P)H oxidase in RVLM. Am J

Physiol Heart Circ Physiol. 288(5):H2271-9, 2005. Epub 2005/01/08. doi:

10.1152/ajpheart.00949.2004. PubMed PMID: 15637113.

*58. Reddy, MK, Patel, KP and Schultz, HD. Differential role of the paraventricular nucleus of the

hypothalamus in modulating the sympathoexcitatory component of peripheral and central

chemoreflexes. Am J Physiol Regul Integr Comp Physiol. 289(3):R789-97, 2005. Epub 2005/05/28.

doi: 10.1152/ajpregu.00222.2005. PubMed PMID: 15919733.

59. Gao, L, Wang, W, Li, YL, Schultz, HD, Liu, D, Cornish, KG and Zucker, IH. Simvastatin therapy

normalizes sympathetic neural control in experimental heart failure: roles of angiotensin II type 1

receptors and NAD(P)H oxidase. Circulation. 112(12):1763-70, 2005. Epub 2005/09/15. doi:

10.1161/CIRCULATIONAHA.105.552174. PubMed PMID: 16157767.

*60. Li, YL and Schultz, HD. Enhanced sensitivity of Kv channels to hypoxia in the rabbit carotid

body in heart failure: role of angiotensin II. J Physiol. 575(Pt 1):215-27, 2006. Epub 2006/06/17.

doi: 10.1113/jphysiol.2006.110700. PubMed PMID: 16777942; PubMed Central PMCID:

PMC1819433.

61. Li, YL, Xia, XH, Zheng, H, Gao, L, Li, YF, Liu, D, . . . Schultz, HD. Angiotensin II enhances

carotid body chemoreflex control of sympathetic outflow in chronic heart failure rabbits. Cardiovasc

Res. 71(1):129-38, 2006. Epub 2006/05/03. doi: 10.1016/j.cardiores.2006.03.017. PubMed PMID:

16650840.

62. Li, YL, Gao, L, Zucker, IH and Schultz, HD. NADPH oxidase-derived superoxide anion mediates

angiotensin II-enhanced carotid body chemoreceptor sensitivity in heart failure rabbits. Cardiovasc

Res. 75(3):546-54, 2007. Epub 2007/05/15. doi: 10.1016/j.cardiores.2007.04.006. PubMed PMID:

17499230; PubMed Central PMCID: PMC2062532.

63. Gao, L, Pan, YX, Wang, WZ, Li, YL, Schultz, HD, Zucker, IH and Wang, W. Cardiac

sympathetic afferent stimulation augments the arterial chemoreceptor reflex in anesthetized rats. J

Appl Physiol. 102(1):37-43, 2007. Epub 2006/08/12. doi: 10.1152/japplphysiol.00681.2006.


64. Reddy, MK, Schultz, HD, Zheng, H and Patel, KP. Altered nitric oxide mechanism within the

paraventricular nucleus contributes to the augmented carotid body chemoreflex in heart failure. Am J

Physiol Heart Circ Physiol. 292(1):H149-57, 2007. Epub 2006/08/08. doi:

10.1152/ajpheart.00117.2006. PubMed PMID: 16891408.


24

65. Zucker, IH, Schultz, HD and Wang, W. Increased mechanoreceptor/metaboreceptor stimulation

explains the exaggerated exercise pressor reflex seen in heart failure. J Appl Physiol. 102(1):498;

author reply 504-5, 2007. Epub 2007/01/09. doi: 10.1152/japplphysiol.01247.2006. PubMed PMID:

17209163.

*66. Schultz, HD, Li, YL and Ding, Y. Arterial chemoreceptors and sympathetic nerve activity:

implications for hypertension and heart failure. Hypertension. 50(1):6-13, 2007. Epub 2007/05/16.

doi: 10.1161/HYPERTENSIONAHA.106.076083. PubMed PMID: 17502495.

67. Schultz, HD and Li, YL. Carotid body function in heart failure. Respir Physiol Neurobiol.

157(1):171-85, 2007. Epub 2007/03/22. doi: 10.1016/j.resp.2007.02.011. PubMed PMID: 17374517;


*68. Ding, Y, Li, YL and Schultz, HD. Downregulation of carbon monoxide as well as nitric oxide

contributes to peripheral chemoreflex hypersensitivity in heart failure rabbits. J Appl Physiol.

105(1):14-23, 2008. Epub 2008/03/22. doi: 10.1152/japplphysiol.01345.2007. PubMed PMID:


69. Kleiber, AC, Zheng, H, Schultz, HD, Peuler, JD and Patel, KP. Exercise training normalizes

enhanced glutamate-mediated sympathetic activation from the PVN in heart failure. Am J Physiol

Regul Integr Comp Physiol. 294(6):R1863-72, 2008. Epub 2008/04/04. doi:

10.1152/ajpregu.00757.2007. PubMed PMID: 18385465.

*70. Li, YL, Ding, Y, Agnew, C and Schultz, HD. Exercise training improves peripheral chemoreflex

function in heart failure rabbits. 105(3):782-90, 2008. Epub 2008/06/28. doi:

10.1152/japplphysiol.90533.2008. PubMed PMID: 18583379; PubMed Central PMCID:

PMC2536814.

71. Li, YL, Tran, TP, Muelleman, R and Schultz, HD. Blunted excitability of aortic baroreceptor

neurons in diabetic rats: involvement of hyperpolarization-activated channel. Cardiovasc Res.

79(4):715-21, 2008. Epub 2008/06/06. doi: 10.1093/cvr/cvn141. PubMed PMID: 18524809.

72. Schultz, HD. Nitric oxide regulation of autonomic function in heart failure. Curr Heart Fail Rep.

6(2):71-80, 2009. Epub 2009/06/03. PubMed PMID: 19486590; PubMed Central PMCID:

PMC2804940.

*73. Ding, Y, Li, YL, Zimmerman, MC, Davisson, RL and Schultz, HD. Role of CuZn superoxide

dismutase on carotid body function in heart failure rabbits. Cardiovasc Res. 81(4):678-85, 2009.

Epub 2008/12/19. doi: 10.1093/cvr/cvn350. PubMed PMID: 19091790; PubMed Central PMCID:

PMC2642603.

74. Zucker, IH, Schultz, HD, Patel, KP, Wang, W and Gao, L. Regulation of central angiotensin type

1 receptors and sympathetic outflow in heart failure. Am J Physiol Heart Circ Physiol.

297(5):H1557-66, 2009. Epub 2009/09/01. doi: 10.1152/ajpheart.00073.2009. PubMed PMID:


75. Yin, JX, Yang, RF, Li, S, Renshaw, AO, Li, YL, Schultz, HD and Zimmerman, MC.

Mitochondria-produced superoxide mediates angiotensin II-induced inhibition of neuronal potassium

current. Am J Physiol Cell Physiol. 298(4):C857-65, 2010. Epub 2010/01/22. doi:

10.1152/ajpcell.00313.2009. PubMed PMID: 20089930; PubMed Central PMCID: PMC3115892.

76. Marcus, NJ, Li, YL, Bird, CE, Schultz, HD and Morgan, BJ. Chronic intermittent hypoxia

augments chemoreflex control of sympathetic activity: role of the angiotensin II type 1 receptor.


25

Respir Physiol Neurobiol. 171(1):36-45, 2010. Epub 2010/02/16. doi: 10.1016/j.resp.2010.02.003.


*77. Ding, Y, Li, YL, Zimmerman, MC and Schultz, HD. Elevated mitochondrial superoxide

contributes to enhanced chemoreflex in heart failure rabbits. Am J Physiol Regul Integr Comp

Physiol. 298(2):R303-11, 2010. Epub 2009/11/20. doi: 10.1152/ajpregu.00629.2009. PubMed

PMID: 19923358; PubMed Central PMCID: PMC2828171.

78. Rosenbaugh, EG, Roat, JW, Gao, L, Yang, RF, Manickam, DS, Yin, JX, . . . Zimmerman, MC.

The attenuation of central angiotensin II-dependent pressor response and intra-neuronal signaling by

intracarotid injection of nanoformulated copper/zinc superoxide dismutase. Biomaterials.

31(19):5218-26, 2010. Epub 2010/04/10. doi: 10.1016/j.biomaterials.2010.03.026. PubMed PMID:


79. Li, YL, Zheng, H, Ding, Y and Schultz, HD. Expression of neuronal nitric oxide synthase in

rabbit carotid body glomus cells regulates large-conductance Ca2+-activated potassium currents. J

Neurophysiol. 103(6):3027-33, 2010. Epub 2010/04/02. doi: 10.1152/jn.01138.2009. PubMed


80. Gao, L, Li, Y, Schultz, HD, Wang, WZ, Wang, W, Finch, M, . . . Zucker, IH. Downregulated

Kv4.3 expression in the RVLM as a potential mechanism for sympathoexcitation in rats with chronic

heart failure. Am J Physiol Heart Circ Physiol. 298(3):H945-55, 2010. Epub 2010/01/02. doi:

10.1152/ajpheart.00145.2009. PubMed PMID: 20044444; PubMed Central PMCID: PMC2838543.

81. Schultz, HD. Angiotensin and carotid body chemoreception in heart failure. Curr Opin

Pharmacol. 11(2):144-9, 2011. Epub 2011/01/19. doi: 10.1016/j.coph.2010.12.004. PubMed PMID:


82. Yang, RF, Yin, JX, Li, YL, Zimmerman, MC and Schultz, HD. Angiotensin-(1-7) increases

neuronal potassium current via a nitric oxide-dependent mechanism. Am J Physiol Cell Physiol.

300(1):C58-64, 2011. Epub 2010/10/29. doi: 10.1152/ajpcell.00369.2010. PubMed PMID:


*83. Ding, Y, Li, YL and Schultz, HD. Role of blood flow in carotid body chemoreflex function in

heart failure. J Physiol. 589(Pt 1):245-58, 2011. Epub 2010/11/17. doi:


84. Schlenker, EH and Schultz, HD. Hypothyroidism attenuates SCH 23390-mediated depression of

breathing and decreases D1 receptor expression in carotid bodies, PVN and striatum of hamsters.

Brain Res. 1401:40-51, 2011. Epub 2011/06/15. doi: 10.1016/j.brainres.2011.05.034. PubMed


85. Schultz, HD and Marcus, NJ. Heart failure and carotid body chemoreception. Adv Exp Med Biol.

758:387-95, 2012. Epub 2012/10/20. doi: 10.1007/978-94-007-4584-1_52. PubMed PMID:

23080187.

86. Marcus, NJ, Philippi, NR, Bird, CE, Li, YL, Schultz, HD and Morgan, BJ. Effect of AT1 receptor

blockade on intermittent hypoxia-induced endothelial dysfunction. Respir Physiol Neurobiol.

183(2):67-74, 2012. Epub 2012/06/26. doi: 10.1016/j.resp.2012.05.025. PubMed PMID: 22728949;


87. Zucker, IH, Patel, KP and Schultz, HD. Neurohumoral stimulation. Heart Fail Clin. 8(1):87-99,

2012. Epub 2011/11/24. doi: 10.1016/j.hfc.2011.08.007. PubMed PMID: 22108729; PubMed

Central PMCID: PMC3224981.


26

88. Schlenker, EH and Schultz, HD. Hypothyroidism stimulates D2 receptor-mediated breathing in

response to acute hypoxia and alters D2 receptors levels in carotid bodies and brain. Respir Physiol

Neurobiol. 180(1):69-78, 2012. Epub 2011/11/05. doi: 10.1016/j.resp.2011.10.013. PubMed PMID:


89. Patel, KP and Schultz, HD. Angiotensin peptides and nitric oxide in cardiovascular disease.

Antioxid Redox Signal. 19(10):1121-32, 2012. Epub 2012/04/03. doi: 10.1089/ars.2012.4614.


90. Schultz, HD, Del Rio, R, Ding, Y and Marcus, NJ. Role of neurotransmitter gases in the control

of the carotid body in heart failure. Respir Physiol Neurobiol. 184(2):197-203, 2012. Epub

2012/07/31. doi: 10.1016/j.resp.2012.07.010. PubMed PMID: 22842006; PubMed Central PMCID:

PMC3483421.

91. Schultz, HD. The paradox of carbon monoxide and the heart. Am J Respir Crit Care Med.

186(7):582-3, 2012. Epub 2012/10/03. doi: 10.1164/rccm.201207-1341ED. PubMed PMID:

23027850.

92. Zucker, IH, Patel, KP and Schultz, HD. Be sympathetic to your nervous system. J Appl Physiol.

113(8):1292-3, 2012. Epub 2012/08/04. doi: 10.1152/japplphysiol.00911.2012. PubMed PMID:

22858623.

93. Schultz, HD, Marcus, NJ and Del Rio, R. Role of the carotid body in the pathophysiology of heart

failure. Curr Hypertens Rep. 15(4):356-62, 2013. Epub 2013/07/05. doi: 10.1007/s11906-013-0368-

x. PubMed PMID: 23824499; PubMed Central PMCID: PMC3801176.

94. Del Rio, R, Marcus, NJ and Schultz, HD. Carotid Chemoreceptor Ablation Improves Survival in

Heart Failure: Rescuing Autonomic Control of Cardiorespiratory Function. J Am Coll Cardiol.

2013;62(25):2422-30. Epub 2013/09/10. doi: 10.1016/j.jacc.2013.07.079. PubMed PMID:


*95. Del Rio, R, Marcus, NJ and Schultz, HD. Inhibition of hydrogen sulfide restores normal

breathing stability and improves autonomic control during experimental heart failure. J Appl

Physiol. 114(9):1141-50, 2013. Epub 2013/03/02. doi: 10.1152/japplphysiol.01503.2012. PubMed


96. Li S, Case AJ, Yang RF, Schultz HD, Zimmerman MC. Over-expressed copper/zinc superoxide

dismutase localizes to mitochondria in neurons inhibiting the angiotensin II-mediated increase in

mitochondrial superoxide. Redox biology. 2:8-14, 2013;. Epub 2013/12/24. doi:

10.1016/j.redox.2013.11.002. PubMed PMID: 24363997; PubMed Central PMCID: PMC3863132.

*97. Marcus, NJ, Del Rio, R, Schultz, EP, Xia, XH and Schultz, HD. Carotid Body Denervation

Improves Autonomic and Cardiac Function and Attenuates Disordered Breathing in Congestive

Heart Failure. J Physiol. 592(Pt 2):391-408, 2014. Epub 2013/11/20. doi:


*98. Haack, KV, Marcus, NJ, Del Rio, R, Zucker, IH, Schultz, HD. Simvastatin treatment attenuates

increased respiratory variability and apnea/hyponea index in rats with chronic heart failure.

Hypertension. 63(5):1041-9, 2014. Epub 2014/02/12. doi:

10.1161/HYPERTENSIONAHA.113.02535. PubMed PMID: 24516105.

99. Schlenker EH, Del Rio R, Schultz HD. Hypothyroidism affects D2 receptor-mediated breathing

without altering D2 receptor expression. Respir Physiol Neurobiol. 193:29-37, 2014. Epub

2014/01/18. doi: 10.1016/j.resp.2014.01.005. PubMed PMID: 24434437.


27

100. Marcus NJ, Del Rio R, Schultz HD. Reply from Noah J. Marcus, Rodrigo Del Rio and Harold D.

Schultz. J Physiol. 592(Pt 8):1905-6, 2014. Epub 2014/04/17. doi: 10.1113/jphysiol.2014.273565.


101. Schultz HD. The arterial chemoreflex and cardiac stress in heart failure: nothing to be sheepish

about. Exp Physiol. 99(8):1029-30, 2014. Epub 2014/08/03. doi: 10.1113/expphysiol.2014.081299.


102. Schultz HD, Marcus NJ, Del Rio R. Mechanisms of carotid body chemoreflex dysfunction

during heart failure. Exp Physiol. 100(2):124-9, 2015. Epub 2014/11/16. doi:

10.1113/expphysiol.2014.079517. PubMed PMID: 25398713.

103. Del Rio R, Andrade DC, Marcus NJ, Schultz HD. Selective carotid body ablation in

experimental heart failure: a new therapeutic tool to improve cardiorespiratory control. Exp Physiol.

100(2):136-42, 2015. Epub 2014/11/16. doi: 10.1113/expphysiol.2014.079566. PubMed PMID:

25398714.

104. Marcus NJ, Del Rio R, Schultz HD. Central role of carotid body chemoreceptors in disordered

breathing and cardiorenal dysfunction in chronic heart failure. Front Physiol. 5:438, 2014. Epub

2014/12/17. doi: 10.3389/fphys.2014.00438. PubMed PMID: 25505417; PubMed Central PMCID:

PMC4241833.

105. Zucker IH, Schultz HD, Patel KP, Wang H. Modulation of angiotensin II signaling following

exercise training in heart failure. Am J Physiol Heart Circ Physiol. 308(8):H781-H91, 2015. Epub

2015/02/15. doi: 10.1152/ajpheart.00026.2015. PubMed PMID: 25681422; PubMed Central

PMCID: PMC4398865.

106. Schultz HD, Marcus NJ, Del Rio R. Role of the Carotid Body Chemoreflex in the

Pathophysiology of Heart Failure: A Perspective from Animal Studies. Adv Exp Med Biol. 860:167-

85, 2015;. Epub 2015/08/26. doi: 10.1007/978-3-319-18440-1_19. PubMed PMID: 26303479.

107. Marcus NJ, Pugge C, Mediratta JK, Schiller AM, Del Rio R, Zucker IH, et al. Exercise Training

Attenuates Chemoreflex-Mediated Reductions of Renal Blood Flow in Heart Failure. Am J Physiol

Heart Circ Physiol. 309(2):H259-66, 2015. doi: 10.1152/ajpheart.00268.2015. PubMed PMID:


108. Schlenker EH, Del Rio R, Schultz HD. In adult female hamsters hypothyroidism stimulates D1

receptor-mediated breathing without altering D1 receptor expression. Respir Physiol Neurobiol.

218:32-9. 2015. Epub 2015/08/02. doi: 10.1016/j.resp.2015.07.011. PubMed PMID: 26232642;


109. Del Rio R, Iturriaga R, Schultz HD. Editorial: Carotid body: a new target for rescuing neural

control of cardiorespiratory balance in disease. Frontiers in physiology. 6:181, 2015. Epub

2015/07/16. doi: 10.3389/fphys.2015.00181. PubMed PMID: 26175689; PubMed Central PMCID:

PMC4483515.

110. Torday JS, Zuo L, Chuang CC, Huszczuk A, Poon CS, Del Rio R, et al. Commentaries on

Viewpoint: Precedence and autocracy in breathing control. J Appl Physiol (1985). 118(12):1557-9,

2015. Epub 2015/06/17. doi: 10.1152/japplphysiol.00229.2015. PubMed PMID: 26078435.

111. Andrade DC, Lucero C, Toledo C, Madrid C, Marcus NJ, Schultz HD, Del Rio R. Relevance of

the Carotid Body Chemoreflex in the Progression of Heart Failure. Biomed Res Int. 2015:467597,


28

2015;. doi: 10.1155/2015/467597. Epub 2015 Dec 8. Review PMID: 26779536; PubMed Central

PMCID: PMC4686619.111.

112. Pugge C, Mediratta J, Marcus NJ, Schultz HD, Schiller AM, Zucker IH. Exercise training

normalizes renal blood flow responses to acute hypoxia in experimental heart failure: role of the

alpha1-adrenergic receptor. J Appl Physiol. 120(3):334-43, 2016. Epub 2015/11/27. doi:

10.1152/japplphysiol.00320.2015. PubMed PMID: 26607245; PubMed Central PMCID:

PMC4740500.

113. Ardell JL, Andresen MC, Armour JA, Billman GE, Chen PS, Foreman RD, et al. Translational

Neurocardiology: preclinical models and cardioneural integrative aspects. J Physiol. 594(14):3877-

909, 2016. Epub 2016/04/22. doi: 10.1113/JP271869. PubMed PMID: 27098459; PubMed Central

PMCID: PMC4945715.

114. Toledo C, Andrade DC, Lucero C, Schultz HD, Marcus N, Retamal M, et al. Contribution of

peripheral and central chemoreceptors to sympatho-excitation in heart failure. J Physiol. 595 : 43-51.

2017. Epub 2016/05/25. doi: 10.1113/JP272075. PubMed PMID: 27218485.

115. Toledo C, Andrade DC, Lucero C, Arce-Alvarez A, Diaz HS, Aliaga V, Schultz HD, Marcus NJ,

Manriquez M, Faundez M, Del Rio R. Cardiac diastolic and autonomic dysfunction are aggravated

by central chemoreflex activation in heart failure with preserved ejection fraction rats. J Physiol.

595(8):2479-2495, 2017. doi: 10.1113/JP273558. Epub 2017 Mar 19. PubMed PMID: 28181258;


116. Schultz HD. Epigenetic influences on carotid body function: a new snag in the road to treating

sleep apnoea. J Physiol. 595(3):629-630, 2017. doi:10.1113/JP273289. PubMed PMID: 28145012;


117. van Bilsen M, Patel H, Bauersachs J, Böhm M, Borggreve M, Brutsaert D, Coats AJS, de

Keulenaer, Filippatos GS, Floras J, Grassi G, Jankowska J, Kornet L, Lunde IG, Maack C, Pollesello

P, Ponikowski P, Ruschitzka F, Sabbah H, Schultz HD, Severovic P, Slart RJHA, Taggart P,

Tocchetti CG, van Laake LW, Zannad F, Heymans S and Lyon AR. The autonomic nervous system

as a therapeutic target in heart failure: a scientific position statement from the Translational Research

Committee of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail.

19(11):1361-1378, 2017. doi: 10.1002/ejhf.921. [Epub ahead of print] PMID: 28949064

118. Andrade DC, Arce-Alvarez A, Toledo C, Diaz HS, Lucero C, Schultz HD, Marcus NJ, Del Rio

R. Exercise training improves cardiac autonomic control, cardiac function, and arrhythmogenesis in

rats with preserved-ejection fraction heart failure. J Appl Physiol (1985). 123(3):567-577, 2017. doi:

10.1152/japplphysiol.00189.2017. Epub 2017 Jun 15. PubMed PMID: 28620053.

119. Del Rio R, Andrade DC, Toledo C, Diaz HS, Lucero C, Arce-Alvarez A, Marcus NJ, Schultz

HD. Carotid Body-Mediated Chemoreflex Drive in The Setting of low and High Output Heart

Failure. Sci Rep. 7(1):8035, 2017. doi: 10.1038/s41598-017-08142-3. PubMed PMID: 28808320;


120. Marcus NJ, Del Rio R, Ding Y, Schultz HD. KLF2 mediates enhanced chemoreflex sensitivity,

disordered breathing and autonomic dysregulation in heart failure. J Physiol. 596(15):3171-3185,

2018. doi: 10.1113/JP273805. PubMed PMID: 29023738; PubMed Central PMCID: PMC6068211.

121. Andrade, DC, Arce-Alvarez, A, Toledo, C, Diaz, HS, Lucero, C, Quintanilla, RA, . . . Del Rio,

R. Revisiting the physiological effects of exercise training on autonomic regulation and chemoreflex


29

control in heart failure: does ejection fraction matter? Am J Physiol Heart Circ Physiol. 314(3):H464-

H474, 2018. doi: 10.1152/ajpheart.00407.2017. PubMedPMID: 29167119; PubMed Central PMCID:

PMC6048457.

122. Schultz HD. Visualizing data in research articles. J Physiol. 96(16):3431-3432, 2018. doi:

10.1113/JP276501. PubMed PMID: 30133812; PubMed Central PMCID: PMC6092274.

123. Shanks J, Xia Z, Lisco SJ, Rozanski GJ, Schultz HD, Zucker IH, Wang HJ. Sympatho-excitatory

response to pulmonary chemosensitive spinal afferent activation in anesthetized, vagotomized rats.

Physiol Rep. 6(12):e13742, 2018. doi: 10.14814/phy2.13742. PubMed PMID: 29906340; PubMed

Central PMCID: PMC6003656.

124. Schultz HD. Advances in cellular and integrative control of oxygen and carbon dioxide

homeostasis. J Physiol. 596(15):2933-2934, 2018. doi: 10.1113/JP276326. PubMed PMID:


125. Lewis R, Hackfort BT, Schultz HD. Chronic Heart Failure Abolishes Circadian Rhythms in

Resting and Chemoreflex Breathing. Adv Exp Med Biol. 1071:129-136, 2108. doi: 10.1007/978-3-

319-91137-3_16. PubMed PMID: 30357743.

126. Wafi AM, Hong J, Rudebush TL, Yu L, Hackfort BT, Wang HJ, Schultz HD, Zucker IH, Gao L.

Curcumin Improves Exercise Performance of Mice with Coronary Artery Ligation Induced HFrEF:

Nrf2 and Antioxidant Mechanisms in Skeletal Muscle. J Appl Physiol (1985) in press Nov 21. 2018.

doi: 10.1152/japplphysiol.00654.2018. [Epub ahead of print] PubMed PMID: 30462567.

* Selected for editorial highlight

B. ARTICLES SUBMITTED

N/A

C. CHAPTERS IN BOOKS

Zehr, J.E., H.D. Schultz, and A. Livnat. Modification of the carotid sinus reflex by a direct action of

propranolol. In: Proceedings of a Symposium on Anti-Hypertensive Mechanisms of Propranolol, ed.

H. Sokabe, Life Science Publishing Co., Japan, pp. 61-69, 1981.

Thompson, A.B., H.D. Schultz, J.H. Sisson, and S.I. Rennard. Airway Mucociliary Clearance, in:

Pulmonary and Critical Care Medicine, eds. R.C. Bone et al., Mosby Year Book Inc., Part E,

Chapter 3, pp 1-12, 1993.

Zucker, I.H., W. Wang, and H.D. Schultz. Cardiac receptor activity in heart failure: Implications for

the control of sympathetic nerve activity. In Control of the Cardiovascular and Respiratory Systems

in Health and Disease, eds. M.C. Kaufman and C.T. Kappagoda, Plenum Pub. Co., pp. 109-124,

1995.

Zucker, I.H., W. Wang, M. Brandle, and H.D. Schultz. Baroreflex and cardiac reflex control of the

circulation in pacing-induced heart failure. In Pathophysiology of Tachycardia-lnduced Heart

Failure, ed. F.G. Spinale, Futura Pub. Co., Chapter 11, pp. 193-226, 1996.


30

Schultz, H.D. Cardiac vagal chemosensory function in patho-physiological states. In: Annals of the

New york Academy of Sciences ed. M. Chapleau. Vol 940 pp 59-73, 2001.

Li, Y-F., Wang Y, Channon KM, Schultz, HD, Zucker, IH, Patel KP. Manipulation of Neuronal

Nitric Oxide Synthase within the Paraventricular Nucleus using Adenovirus and Antisens

Technology. IN: Methods in Molecular Medicine, vol. 112: Molecular cardiology: Methods and

Protocols. ed. Z. Sun. Humana Press, 2004.

Schultz, H.D. Cardiac Vagal Afferent Nerves. In: Advances in Vagal Afferent Neurobiology eds. B.

J. Undem, D. Weinreich. Frontiers in Neuroscience. CRC Press. Pp. 351-375, 2005.

Schultz, H.D. Specialized Methods: Electrophysiology. In: Redox Biochemistry. ed. R. Banerjee.

Wiley & Sons, Inc., pp. 263-272, 2008.

D. ABSTRACTS

Schultz, H.D. and J.E. Zehr. Effect of central and peripheral beta adrenergic blockade on renin release

during hemorrhage. The Physiologist 20:84, 1977.

Schultz, H.D. and J.E. Zehr. Effect of propranolol on the isolated carotid sinus baroreceptor. The

Physiologist 21:105, 1978.

Schultz, H.D. A. Livnat, and J.E. Zehr. Afferent, efferent, and central neural influences on plasma

renin activity (PRA) during activation of the carotid sinus reflex. Fed. Proc. 38:1232, 1979.

Schultz, H.D. D.C. Fater, W.D. Sundet, and K.L. Goetz. Renal responses to partial obstruction at

various points of the intrathoracic circulation of conscious dogs. The Physiologist 23:129, 1980.

Fater, D.C., W.D. Sundet, H.D. Schultz, and K.L. Goetz. Cardiac denervation eliminates the diuretic

response elicited by increasing left atrial pressure with a balloon. Fed. Proc. 39:951, 1980.

Goetz, K.L., D.C. Fater, H.D. Schultz, and W.D. Sundet. Diuretic response to left atrial distension is

eliminated after cardiac denervation. Adv. Physiol. Sci., Vol. II, Kidney and Body Fluids, L. Takacs

(ed.), pp. 643-646, 1981.

Schultz, H.D., A.M. Roberts, H.L. Hahn, J.A. Nadel, H.M. Coleridge, and J.C.G. Coleridge.

Mechanism of airway constriction and secretion evoked by laryngeal administration of S02 in dogs.

The Physiologist 25:226, 1982.

Roberts, A.M., H.L. Hahn, H.D. Schultz, J.A. Nadel, H.M. Coleridge, and J.C.G.Coleridge. Afferent

vagal C-fibers are responsible for the reflex airway constriction and secretion evoked by pulmonary

administration of S02 in dogs. The Physiologist 25: 226, 1982.

Roberts, A.M., H.D. Schultz, T.E. Pisarri, H.M. Coleridge, and J.C.G. Coleridge. Contraction of

airway smooth muscle evoked by activation of the coronary chemoreflex in dogs. The Physiologist

27: 223, 1984.

Roberts, A.M., J. Bhattacharya, H.D. Schultz, H.M. Coleridge, and J.C.G. Coleridge. Stimulation of

pulmonary and bronchial C-fibers by interstitial edema in dogs. The Physiologist 26:A-38, 1983.

Green, J.F., N.D. Schmidt, H.D. Schultz, A.M. Roberts, H.M. Coleridge, and J.C.G. Coleridge.

Evidence that pulmonary C-fibers trigger both the apnea and rapid shallow breathing of the

pulmonary chemoreflex. The Physiologist 26:A-39, 1983.


31

Schultz, H., A.M. Roberts, C. Bratcher, H.M. Coleridge, J.C.G. Coleridge, and B. Davis. Reflex

increase of canine tracheal gland secretion evoked by stimulation of pulmonary C-fibers. The

Physiologist 26:A-124, 1983.

Roberts, A.M., H.D. Schultz, T.E. Pisarri, H.M. Coleridge, and J.C.G. Coleridge. Contraction of

airway smooth muscle evoked by activation of the coronary chemoreflex in dogs. The Physiologist

27:223, 1984.

Schultz, H.D., T.E. Pisarri, H.M. Coleridge, and J.C.G. Coleridge. Cardiovascular reflexes evoked by

C-fiber baroreceptors in the carotid sinus of dog. The Physiologist 27:247,1984.

Roberts, A.M., T.E. Pisarri, H.D. Schultz, H.M. Coleridge, and J.C.G. Coleridge. Reflex relaxation of

airway smooth muscle evoked by chemical stimulation of cardiac sympathetic afferents in dogs.

Fed. Proc. 44: 837, 1985.

Schultz, H.D., T.E. Pisarri, H.M, Coleridge, and J.C.G. Coleridge. Absence of acute resetting by C-

fiber baroreceptors in the carotid sinus of dogs. Fed. Proc. 44: 1033, 1985.

Schultz, H.D., T.E. Pisarri, H.M. Coleridge, and J.C.G. Coleridge. Graded changes in airway smooth

muscle tone evoked by the carotid baroreflex in dogs. The Physiologist 28(4):305, 1985.

Schultz, H.D., H.M. Coleridge, and J.C.G. Coleridge. Graded changes in total lung resistance evoked

by the carotid baroreflex in dogs, The Physiologist 29: 143, 1986.

Davis, B., H.D. Schultz, J. Goodman, H.M. Coleridge, and J.C.G. Coleridge. Effect of carotid

baroreflex and coronary chemoreflex on tracheal smooth muscle and submucosal glands in dogs. The

PhysioIogist 29: 146, 1986.

Yu, J., H.D. Schultz, J. Goodman, and B. Davis. Pulmonary rapidly adapting receptors reflexly evoke

tracheal submucosal gland secretion in dog. The Physiologist 29: 146, 1986.

Pisarri, T.E., A. Jonzon, H.D. Schultz, H.M. Coleridge, and J.C.G. Coleridge. Effect of high

frequency oscillatory ventilation on pulmonary vagal afferent in dog. Fed.Proc. 46:662,1987.

Schultz, H.D., A. Jonzon, T.E. Pisarri, J. Goodman, B. Davis, H.M. Coleridge, and J.C.G. Coleridge.

High frequency oscillatory ventilation stimulates tracheal submucosal gland secretion in dogs. Fed.

Proc. 46: 661, 1987.

Schultz, H.D., H.M. Coleridge, and J.C.G. Coleridge. Relationship of carotid A- and C-fiber

baroreceptor activities to sinus wall mechanics. The Physiologist 30: 237, 1987.

Schultz, H.D., D. Gardner, C. Deschepper, and J.C.G. Coleridge. Vagal afferent C-fibers mediate the

reflex decrease in renal nerve activity evoked by atrial natriuretic factor in rats. Circulation Suppl.

Part II, 76: IV-207, 1987.

Schultz, H.D., M.K. Steele, and D.G. Gardner. Renal sympathetic and cardiovascular responses to

central administration of angiotensin II (AII) and atrial natriuretic peptide (ANP). The FASEB

Journal 3: A1008, 1989.

Rotto, D.M., H.D. Schultz, J.C. Longhurst, and M.P. Kaufman. Sensitization of group III afferents to

static contraction by products of arachidonic acid metabolism. The FASEB Journal 3: A856, 1989.

Steele, M.K., D.G. Gardner, and H.D. Schultz. Central interactions between atrial natriuretic peptide

(ANP) and angiotensin II (AII) on sympathetic outflow. The FASEB Journal 4: A1193, 1990.

Schultz, H.D., J.C.G. Coleridge, and H.M. Coleridge. Absence of acute resetting by carotid C-fiber

baroreceptors is not related to pulse pressure. The FASEB Journal 4: A707, 1990.


32

Coleridge, J.C.G., H.M. Coleridge, T.E. Pisarri, and H.D. Schultz. Stimulation of cardiac vagal

chemosensitive C-fibers by coronary occlusion in dogs The FASEB Journal 4: A707, 1990.

Coleridge, H.M., J.C.G. Coleridge, B. Davis, and HD Schultz. Reflex stimulation of tracheal

submucosal gland secretion by cigarette smoke in dogs. The FASEB Journal 4: A1093, 1990.

Schultz, H.D. Stimulation of chemosensitive endings by acetycholine in the carotid sinus of dogs is

mediated by the endothelium. The FASEB Journal 5: A383, 1991.

Schultz, H.D. Stimulation of chemosensitive endings by acetycholine in the carotid sinus of dogs is

mediated by an endothelial cyclooxygenase product. Circulation Suppl. 84: II-99, 1991.

Ustinova, E.E., T.C. Wilson, R.M. Snider, and H.D. Schultz. Effect of substance P and the NK-1

receptor antagonist, CP-96,345, on tracheal submucosal gland secretion in dogs. The FASEB Journal

6: A1269, 1992.

Schultz, H.D., E.E. Ustinova, and T.C. Wilson. Cigarette smoke increases tracheal submucosal gland

secretion via a nicotinic effect on airway ganglia. The FASEB Journal 6: A1268, 1992.

Bergren, D.R., E.E. Ustinova, and H.D. Schultz. Neutral endopeptidase inhibition potentiates the

effects of capsaicin on C-fiber activity in rats. The FASEB Journal 6: A1268, 1992.

Zucker, IH W. Wang, H.D. Schultz, and M. Brandle. Acute ethanol induces endothelial dependent

carotid artery constriction. The FASEB Journal 6: A1258, 1992.

Schultz, H.D., E.E. Ustinova, and J. Haselton. Selective stimulation of carotid C-fiber baroreceptors

by catecholamines mediated by the vascular endothelium. The FASEB Journal 7: A95, 1993.

Ustinova, E.E. and H.D. Schultz. Activation of cardiac vagal C-fiber afferents by reactive oxygen

species in rats. The FASEB Journal 7: A98, 1993.

Ustinova, E., D. Bergren, and H.D. Schultz. Neutral endopeptidase and angiotensin-converting

enzyme modulate pulmonary afferent C-fiber responses to endogenous and exogenous mediators.

Am. Rev. Resp. Dis. 147: A662, 1993.

Ozkan, 0., and H.D. Schultz. Acute resetting of slowly adapting pulmonary stretch receptors. Am.

Rev. Resp. Dis. 147: A164, 1993.

Schultz, H.D., and E. Ustinova. Activation of cardiac vagal C-fiber afferents by reactive oxygen

species in rats. XXXII Congress of the International Union of Physiological Sciences, 1993 .

Ustinova, E.E., and H.D. Schultz. Activation of cardiac vagal afferents in ischemia and reperfusion:

prostaglandins vs. oxygen free radicals. Circulation Suppl. 88: I-K, 1993.

Ustinova, E.E., D. Bergren, and H.D. Schultz. Neuropeptide depletion impairs postischemic recovery

of the isolated rat heart. The FASEB Journal, 8: A332, 1994.

Schultz, H.D., W. Wang, E. Ustinova, and I.H. Zucker. Altered responsiveness of cardiac vagal

chemosensitive endings to bradykinin in heart failure. The FASEB Joumal, 8: A859, 1994.

Toews, M.L., E.E. Ustinova, and H.D. Schultz. Lysophosphatidic acid potentiates cholinergic

contraction of isolated airway smooth muscle. The FASEB Journal, 9: A697, 1995.

Schultz, E.E. and E.E. Ustinova. Effect of antioxidant deferoxamine on the reflex changes in renal

sympathetic nerve activity during ischemia and reperfusion in the rat. The FASEB Journal, A900,

1995.


33

Ustinova, E.E. and H.D. Schultz. Reflex changes in renal sympathetic nerve activity during

myocardial ischemia and reperfusion in rats. The FASEB Journal, A901, 1995.

Wang, W., H.D. Schultz, and I.H. Zucker. Effects of hydrogen peroxide on the cardiac sympathetic

afferent reflex in dogs with heart failure. The FASEB Journal, A45, 1995.

Schultz, H.D., and E.E. Ustinova. Protective effect of neuropeptides during myocardial ischemia J.

Molecular and Cellular Cardiology, A44, 1995.

Schultz, H.D., and E.E. Ustinova. Blockade of capsaicin receptors abolishes free radical-induced

activation of cardiac afferent fibers in rats. The FASEB Journal, A16, 1996.

Ustinova, E.E., and H.D. Schultz. Oxygen radicals enhance the sensitivity of cardiac afferents to

chemical stimuli. The FASEB Journal 10: A61, 1996.

Ustinova, E.E., and H.D. Schultz. Protective effect of calcitonin gene-related peptide (CGRP) on the

postischemic recovery of the rat heart. J. Molecular and Cellular Cardiology 28: A190, 1996.

Zucker, I.H. H.D. Schultz, M.P. Olivari, and W. Wang. Cardiac denervation does not normalize

blunted baroreceptor reflex in heart failure. The FASEB Journal 11: A47, 1997.

Sun, S.Y., I.H. Zucker, and H.D. Schultz. Enhanced carotid body chemoreceptor activity in pacing-

induced heart failure rabbits: role of nitric oxide. Circulation Suppl 96: I-70, 1997.

Sun, S.Y., I.H. Zucker, and H.D. Schultz. Enhanced chemoreflex function contributes to sympathetic

hyperactivity and baroreflex deterioration in conscious heart failure rabbits. Circulation Suppl 96:I-

70, 1997.

Ustinova, E.E., and H.D. Schultz. Effect of streptozotocin-induced diabetes on the sensory and reflex

functions of cardiac vagal afferent nerves in rats. Circulation Suppl 96: I-70, 1997.

Tran, T.P., K.J. Rhee, H.D. Schultz, and M. Carl. Effects of neuromuscular blockade on gas exchange

and lung mechanics of dogs during percutaneous transtracheal ventilation. Acad Emerg. Med. 4:

4861 1997.

Sun, S.Y., W. Wang, and H.D. Schultz. Activation of cardiac afferents by arachidonic acid: Relative

contributions of the different metabolic pathways. The FASEB Journal 12:A689, 1998.

Ma, R., H.D. Schultz, and W. Wang. Chronic central infusion of angiotensin II potentiates cardiac

sympathetic afferent reflex. The FASEB Journal 12:A688, 1998.

Barrett, C.J., S.Y. Sun, W. Wang, and H.D. Schultz. Sympathoinhibitory effect of atrial natriuretic

peptide is preserved in rats with heart failure. The FASEB Journal 12:A397 1998.

Tran, T.P., K.J. Rhee, J.C. Stothert, H.D. Schultz, and M. Carl. Effectiveness of percutaneous

transtracheal ventilation (PTV) in a canine model of acute experimental asthma Acad Emerg Med In

press, 1998.

Tran, T.P., K.J. Rhee, and H.D. Schultz. Effectiveness of PTV using an 18 gauge needle and air for

emergency ventilation. Acad Emerg Med In press, 1998.

Barrett, C.J., and H.D. Schultz. Acute vitamin E treatment improves cardiac sympathetic reflex

function in streptozotocin-induced diabetic rats. The FASEB Journal 13:A444, 1999.

Sun, S.Y., W. Wang, I.H. Zucker, and H.D. Schultz. Alteration of peripheral chemoreflex and arterial

baroreflex in heart failure: Role of central angiotensin II. The FASEB Journal 13:A444, 1999.


34

Sun, S.Y., L, Wang, W. Wang, I.H. Zucker, and H.D. Schultz. Exercise training normalizes enhanced

peripheral chemoreflex function in rabbits with heart failure. The FASEB Journal 13:A444, 1999.

Barrett, C.J., and H.D. Schultz. Superoxide anion mediates impaired cardiac vagal reflex function in

streptozotocin-induced daibetic rats. Circulation Suppl. 100:I-130, 1999.

Sun, S.Y., and H.D. Schultz. Effects of arachidonic acid metabolites on the discharge of cardiac

afferents. FASEB Summer Conference: "Neural Mechanisms in Cardiovascular Regulation", 1999.

Wang, W. Cornish, K.G., Schultz, H.D., and I.H. Zucker. Microinjection of AT1 antagonist into the

PVN attenuates the enhanced cardiac sympathetic afferent reflex in dogs with heart failure. The

FASEB Journal 14:A377, 2000.

Sun, S.Y., Nienaber, J., X.-H. Xia, and H.D. Schultz. Peripheral chemoreflex contributes to periodic

breathing and sympathetic activation in heart failure. The FASEB Journal 14:A377, 2000.

Sun, S.Y., Wang, W., and H.D. Schultz. Activation of cardiac afferents by nicotine in rats: role of

oxygen free radicals. The FASEB Journal 14:A376, 2000.

Wang, W., Zhu, G.-Q., Schultz, H.D., and I.H. Zucker. nNOS inhibition potentiates the central effects

of angiotensin II on the cardiac sympathetic aferent reflex. Circulation Suppl. 102: II-350, 2000.

Zeng, Y-C., X-H. Xia, S-Y. Sun, and H.D. Schultz. Evidence for decreased nNOS in the carotid body

of heart failure rabbits. Circulation Suppl. 102: II-349, 2000.

Xia , X-H., S-Y. Sun, K. G. Cornish, Y-C. Zeng, W. Wang, and H.D. Schultz. Effect of carotid body

denervation on Cheyne-Stokes respiration and baroreflex function in heart failure. Circulation Suppl.

102: II-700, 2000.

Sun, S-Y., G. Rozanski, X-H. Xia, and H.D. Schultz. Attenuated potassium current of carotid body

glomus cells in heart failure rabbits. Circulation Suppl. 102: II-105, 2000.

Zeng, Y-C., X-H. Xia, S-Y. Sun, and H.D. Schultz. Attenuated INa in cardiac vagal chemosensory

neurons in diabetic rats. The FASEB Journal. 15:A106, 2001.

Xia , X-H., S-Y. Sun, , Y-C. Zeng, K. G. Cornish, and H.D. Schultz.Domperidone increases

sympathteic nerve activity and triggers Cheyne-Stokes respiration in normal rabbits. The FASEB

Journal.15: A151, 2001.

Sun S-Y., X-H. Xia, Y-C Zeng,.and H.D. Schultz.Exercise training normalizes peripheral

chemoreceptor sensitivity in heart failure: Role of nitric oxide. The FASEB Journal. 15: A780, 2001.

Barrett, C.J. and H.D. Schultz Cardiac afferent function in diabetes: Role of the polyol pathway.

XXXIV International Congress of Physiological Sciences., 2001.

Schultz, H.D., Sun, S-Y., and X-H. Xia. Angiotensin II contributes to the enhanced carotid body

chemoreceptor sensitivity in rabbits with heart failure. XXXIV International Congress of

Physiological Sciences. 2001.

Zeng, Y-C. S-Y Sun., X-H. Xia, P. Reddy, Y. Li, and H.D. Schultz. Effect of exercise and heart

failure on NOS isoforms in the carotid body of rabbits. The FASEB Journal. A829, 2002.

Xia , X-H., S-Y. Sun, K. G. Cornish, P. Reddy, Y-C. Zeng, and H.D. Schultz. Role of dopamine in

the enhancement of the peripheral chemoreflex function in heart failure. The FASEB Journal. 16:

A828, 2002.


35

Zeng, Y-C., S-Y. Sun, G.J. Rozanski, X-H. Xia, P. Reddy, and H.D. Schultz. Superoxide anion

attenuates INa in cardiac vagal chemosensory neurons from diabetic rats. The FASEB Journal. 16:

A829, 2002.

Zeng, Y-C, Li, Y-L, and H. D. Schultz. Oxidative stress and cardiac afferents in diabetes. The FASEB

Journal. 17: A886, 2003.

Li, Y-L, and H.D. Schultz. Blunted Ca++- dependent paotassium current in carotid body glomus cellls

of heart failure rabbit: involvement of nitric oxide. The FASEB Journal. 17: A401, 2003.

Reddy, MPK, Patel, K.P., and H.D. Schultz. Chemoreflex induced sympathoexcitation is modulated

by nitric oxide (NO) within the paraventricular hypothalamic nucleus (PVN). The FASEB Journal.

17: A402, 2003.

Li, Y-L, Xia XH, Li YF, Patel KP, and H.D. Schultz Upregulation of angiotensin II mediates the

enhanced peripheral chemoreceptor sensitivity in heart failure rabbits. Circulation Suppl. 106:IV-

241, 2003.

Gao, L., H.D. Schultz, K.P. Patel, I.H. Zucker and W. Wang. Cardiac sympathetic afferent

stimulation augments the arterial chemoreceptor reflex in normal rats. The FASEB Journal, 18:

A669, 2004.

Li, Y-L., Y. Li, W. Wang, K.G. Cornish, K.P. Patel, I.H. Zucker and H.D. Schultz. Attenuation of

chemoreceptor sensitivity by transfection of Ad.nNOS in carotid body of heart failure rabbits. The

FASEB Journal, 18:A1277, 2004.

Li, Y-L., Y. Li, W. Wang, K.G. Cornish, K.P. Patel, I.H. Zucker and H.D. Schultz. Effect of

Ad.nNOS transfection on outward potassium currents in carotid body glomus cells from heart failure

rabbits. The FASEB Journal, 18:A1277, 2004.

Zeng Y-C. and H.D. Schultz. Effects of oxidative stress on TTX-r Na v1.8 and Na v1.9 I Na in

cardiac afferent vagal neurons in diabetic rats. The FASEB Journal, 18:A1258, 2004.

Gao, L., W. Wang, H.D. Schultz, K.P. Patel and I.H. Zucker. Oxidative stress mediates the effects of

central angiotensin II on baroreflex function in conscious rabbits with heart failure. The FASEB

Journal, 18:A1258, 2004.

Li, Y-L., L. Gao, W. Wang, ,I.H. Zucker, and H.D. Schultz. NADPH oxidase-derived superoxide

anion mediates the angiotensin II-enhanced peripheral chemoreflex sensitivity in heart failure

rabbits. Circulation Suppl. 110: III-265, 2004.

Li, Y-L., H. Zheng, Y. Li, K. P. Patel, and H. D. Schultz. Angiotensin II-superoxide signaling

pathway potentiates the sensitivity of outward K+ channels to hypoxia in carotid body and NG108-15

cells. The FASEB Journal, 19: A1291, 2005.

Li, Y-L., H. Zheng, Y. Li, K. P. Patel, and H. D. Schultz. Involvement of superoxide production on

angiotensin II-blunted outward K+ currents in NG108-15 cells. The FASEB Journal, 19: A1291,

2005.

Gao, L.,W. Wang, Y-L. Li, H. D. Schultz, D. Liu, K. G. Cornish, and I.H Zucker. Simvastatin

therapy normalizes sympathetic neural control in experimental heart failure: the roles of AT1

receptors and NAD(P)H oxidase. The FASEB Journal 19; A1292, 2005.

Gao, L., I. H. Zucker, H. D. Schultz, and W. Wang. Augmented input from cardiac sympathetic

afferents enhances the chemoreceptor reflex in HF rats. The FASEB Journal 19: A1288, 2005.


36

Gao, L., W. Wang, Y.-L. Li, H. D. Schultz, K. G. Cornish, I. H Zucker. Chronic central infusion of

losartan down-regulates the expression of AT1 receptor and NAD(P)H oxidase subunits in RVLM in

rabbist with heart failure. The FASEB Journal 19: A1291, 2005.

Li, Y-L., V. Tek, H. Kim, S.W. Ragsdale, H.D. Schultz. Oxygen sensitivity of K+ channels in rat

carotid body type I cells: involvement of cGMP in a hemoxygenase-carbon monoxide signaling

pathway. Program No. 636.8. 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for

Neuroscience, 2005. Online.

Li, Y-L., and H. D. Schultz. Endogenous neuronal nitric oxide synthase and AT1 receptor do not

mediate the enhanced peripheral chemoreflex function in early stage of chronic heart failure in

rabbits. The FASEB Journal. 20: A1203-1204, 2006.

Ding, Y-F, Y-L Li, and H. D. Schultz. Downregulation of Carbon Monoxide as well as Nitric Oxide

Contributes to Peripheral Chemoreflex Hypersensitivity in Heart Failure Rabbits. The FASEB

Journal 20: Late Breaking Abstracts, 2006.

Gao L, Wang W, Mann E, Finch M, Li YL, Liu D, Schultz HD, Zucker IH. Sympathoexcitation in

chronic heart failure: Ang II induced inhibition of voltage-gated K+ channel, an in vivo and in vitro

study. The FASEB J 20: A1202-A1203, 2006.

Wang, W.-Z., Pan, Y.-X., Gao, L., , Zucker, I. H., Li, Y. L., Schultz, H. D., Wang, W. Activation of

the cardiac sympathetic afferent reflex enhances the neuronal chemosensitivity in the nucleus tractus

solitarius in rats with chronic heart failure. Circulation, 114 In press, 2006.

Ding, Y-F,,Y-L Li, K. G. Cornish, H.D. Schultz. Reduced Blood Flow in Carotid Arteries is a Trigger

Contributing to Peripheral Chemoreflex Hypersensitivity in Chronic Heart Failure Rabbits. The

FASEB J 21:A1268, 2007.

Li, Y-L, and H.D. Schultz. Role of NADPH oxidase-derived superoxide anion on angiotensin II-

enhanced sensitivity of potassium channels to hypoxia in carotid body of congestive heart failure

rabbits. The FASEB J 21:A1268, 2007.

Yin JX, Li YL, Xiao L, Schultz HD, Zimmerman MC. Cytoplasmic and mitochondrial-produced

superoxide mediates angiotensin II (AngII)-induced inhibition of K+ current in CATH.a neurons.

The FASEB J 22: lb150, 2008.

Ding YF, Li YL, Davisson R, Schulz HD. Gene transfer of Cu-Zn superoxide dismutase to the carotid

body reverses enhanced chemoreceptor function in heart failure rabbits. The FASEB J 22: 741.2,

2008.

Li YL, Ding YF, Agnew C, Schultz HD. Exercise training normalizes enhanced peripheral

chemoreflex function in chronic heart failure rabbits. The FASEB J 22: 952.10, 2008.

Li YL, Tran TP, Muelleman R, Schultz HD. Hyperpolarization-activated cyclic nucleotide-gated

channels mediate blunted excitability of aortic baroreceptor neurons in diabetic rats. The FASEB J

22: 1171.22, 2008.

Yin JX, Li YL, Ding YF, Schultz HD. Interplay of angiotensin 1-7 and angiotensin II in the

regulation of voltage-gated potassium current in the glomus cells of carotid body. FASEB Journal.

23:1009.12, 2009.

Ding YF, Li YL, Yin JX, Zimmerman MC, Schultz HD. Adenovirus-mediated gene transfer of Mn

superoxide dismutase to carotid body normalizes enhanced chemoreceptor function in heart failure

rabbits. FASEB Journal 23:957.2, 2009.


37

Marcus NJ, Li YL, Bird CB, Olson EB, Smith SS, Sorenson KI, Schultz HD, and Morgan BJ.

Chronic intermittent hypoxia alters chemoreflex control of lumbar sympathetic nerve activity and

carotid body protein expression. FASEB Journal 23:1008.1, 2009.

Schultz HD, Ding YF, Li YL, Yin JX, Zimmerman MC, Mechanisms of Enhanced Carotid Body

Function in Heart Failure: A Link to Vascular Endothelial Function. Clin Auton Res 19:307, 2009.

Schultz HD, Ding YF, Li YL, Yin JX, Zimmerman MC, Modulation of Oxygen Sensing in the

Carotid Body by Altered Vascular Endothelial Function in Heart Failure. Keystone Symposia on

Molecular and Cellular Biology: Hypoxia: Molecular Mechanisms of Oxygen Sensing and Response

Pathways. 2010

Yang RF, Yin JX, Li YL, Zimmerman MC, Schultz HD. Angiotensin-(1-7) increases neuronal

potassium current via a nitric oxide-dependent mechanism. FASEB Journal 24:809.19, 2010.

Yang RF, Yin JX, Li YL, Schultz HD, Zimmerman MC. Angiotensin-(1-7) inhibits angiotensin II

intra-neuronal signaling. FASEB Journal 24:1051.12, 2010.

Tang YH, Ding YF, Li YL, Zheng Y, Schultz HD. Enhanced Peripheral Chemoreflex Function in

Conscious Rats with Ligation-induced Heart Failure. FASEB Journal 24:1050.2, 2010.

Marcus NJ, Schultz HD. Role of Carotid Body Chemoreflex Function in the Development of Cheyne-

Stokes Respiration During Progression of Congestive Heart Failure FASEB J 25; 25:841.7. 2011:

Pügge C, Curry PL, Clayton SC, Marcus NJ, Schultz HD, Zucker IH. Exercise Training Normalizes

Renal Blood Flow Responses to Acute Hypoxia and Exercise in Experimental Heart Failure.

Circulation 124:A16533, 2011.

Marcus NJ, Haack KKV, Zucker IH, Schultz HD. Simvastatin Treatment Attenuates Enhanced

Carotid Body Chemoreflex Sensitivity in Rats with Heart Failure. Hypertension 58:e33-e183, 2011.

Marcus NJ, Haack KKV, Zucker IH, Schultz HD. Simvastatin Treatment Attenuates Increased

Respiratory Variability and Apnea/Hypopnea Index in Rats with Congestive Heart Failure FASEB

Journal 26:lb829 2012.

Marcus NJ, Li YL, Ding YF, Schultz HD. Role of the carotid body chemoreflex function in the

development of Cheyne-Stokes respiration during the progression of congestive heart failure.

XVIIIth Meeting of the International Society for Arterial Chemoreception. pg. 119. 2011.

Schultz HD. Heart Failure and Carotid Body Chemoreception. XVIIIth Meeting of the International

Society for Arterial Chemoreception. pg. 83. 2011.

Del Rio R, Marcus NJ, Stein G, Schultz HD. Hydrogen sulfide contributes to the enhanced

chemoreflex ventilatory response to acute hypoxia in heart failure rats. FASEB Journal 26;894.20

2012.

Del Rio R, Marcus NJ, Schultz HD. Selective carotid body chemosensory denervation improves

breathing instability and autonomic dysfunction in heart failure rats. The Physiologist 55: C-13,

2012.

Marcus NJ, Del Rio R, Schultz HD. Carotid Body Denervation attenuates increased sympathetic

nerve activity in congestive heart failure. The Physiologist 55: C-22, 2012.

Marcus NJ, Del Rio R, Schultz HD. Carotid body denervation attenuates oscillations in respiratory

rate and sympathetic nerve activity, and decreases apnea/hypopnea index in congestive heart failure.

FASEB Journal 27: 1137.7, 2013.


38

Del Rio R, Marcus NJ, Schultz HD. Carotid body ablation improves survival, breathing disorders and

autonomic control in heart failure rats. FASEB Journal 27: 699.6, 2013.

Marcus NJ, Del Rio R, Schultz HD. Carotid body denervation reduces renal sympathetic nerve

activity and fibrosis, and increases renal blood flow in congestive heart failure. FASEB Journal 28:

875.14, 2014.

Del Rio R, Marcus NJ, Schultz HD. Calorie restriction as a new approach for resetting carotid body

chemoreflex control in heart failure. FASEB Journal 28: 873.11, 2014.

Marcus NJ, Ding Y, Del Rio R, Schultz HD. Reduced Carotid Body KLF2 Expression Contributes to

Autonomic and Respiratory Dysfunction in Chronic Heart Failure. FASEB Journal 29: 2015

Schultz HD. Sympatho-excitatory reflexes in cardiovascular disease: The efficacy of restraining the

carotid body. Curr Res Cardiol 2: 120, 2015.

Schultz HD. Reduced Carotid Body KLF2 expression contributes to autonomic and respiratory

dysfunction in chronic heart failure. Autonomic Neuroscience 192: 17, 2015.

Jesse NE, Raichlin E, Schultz HD. Ventilatory efficiency and oscillatory breathing as clinical markers

of surgical outcomes in heart failure. FASEB Journal 30, 2016.

Hackfort BT, Lewis R, Diaphragm Muscle Function and Antioxidant Levels in Chronic Heart Failure

FASEB J 31:687.19, 2017.

Lewis R, Hackfort BT, Schultz HD. Increased circadian variations in chemoreflex sensitivity in

chronic heart failure FASEB J 31:687.20, 2017.

Gao L, Rudebush TL, Wafi AM, Zucker IH, Schultz HD. Nrf2 Activation by Curcumin Improves

Exercise Performance of Mice with Chronic Heart Failure FASEB J 31:1020.15, 2017.

Lewis R, Seo Y, Hackfort BT, Pozehl B, Schultz HD. Eight weeks of slow deep breathing training

alters cardiorespiratory function and improves functional exercise capacity in chronic heart failure

patients. FASEB J 32:903.16, 2018.

E. INVlTED PRESENTATIONS

Keynote address: “Chemoreflex Dysfunction in Heart Failure: Why It Should Not Be Ignored” 23rd

European Heart Disease and Heart Failure Congress February 19-21, 2018 Paris, France

“Transcriptional regulation of carotid body function by blood flow” International Union of

Physiological Sciences World Congress, Rio de Janeiro, Brazil, August 2017.

"Scientific Premise" one of four presentations/panel discussions at a workshop on Sceintific Rigor at

UNMC campus wide, March 2017.

The Carotid Body in Heart Failure: Awakening a Sleeping Dragon” 2016 Shanghai Cardiovacular

Regulation Symposium. Shanghai, China, October 2016.

“Molecular pathways contributing to carotid body dysfunction in heart failure: Insights for therapy”

Joint Meeting of the American Physiological Society and The Physiological Society, Dublin,

Ireland, July 2016

“Carotid body chemoreceptors: pathophysiology in heart failure” Heart Failure Association of the

European Society of Cardiology, Translational Research Committee Workshop on ‘Automatic

nervous system as a therapeutictarget in heart failure’ Brussels, March 2016.


39

“Reduced Carotid Body KLF2 expression contributes to autonomic and respiratory dysfuction in

chronic heart failure” International Society for Autonomic Neuroscience, Stresa, Italy, 9/27/2015.

“Sympatho-excitatory reflexes in cardiovascular disease: The efficacy of restraining the carotid

body.” Annual Meeting of the International Academy of Cardiovascular Sciences. Omaha, NE

9/10/2015

“The importance of the carotid body in the treatment of cardiovascular and metabolic disease.”

Wright State University, Daytona, Ohio, 9/11/2014.

“Mechanisms of carotid body chemoreflex dysfunction during heart failure.”1st PanAmerican

Congress of Physiological Sciences, Iguassa Falls, Brazil 8/4/2014.

“My Journey Into Heart Failure Research” Univeristy of Nebraska Summer Undergraduate Research

Program (SURP). UNMC, 7/22/2014.

Plenary Lecture: “Importance of the Carotid Body in the Assessment and Treatment of

Cardiovascular and Metabolic Diseases: The Evidence for Heart Failure”.XIXth Meeting of the

International Society of Arterial Chemoreception, Leeds UK, 7/3/2014.

Plenary Lecture: 24th International Symposium of the Autonomic Nervous System. “The Carotid

Body in Heart Failure: Why is it important?” American Autonomic Society, Big Island, HI, 10/24/

2013.

“Can the Carotid Body Really Be That Important in Cardiovascular Disease?” Penn State Hershey

Medical Center, Heart and Vascular Institute. Harrisburg, PA, 10/7/2013.

“Angiotensin and Carotid Body Function in Cardiovascular Disease” 23rd Annual Vascular Biology

and Hypertension Symposium, University of Alabama, Birmingham, AL 10/8/2012

“Carotid Body Denervation as a Potential Therapeutic Intervention in Heart Failure” 23rd Annual

Vascular Biology and Hypertension Symposium, University of Alabama, Birmingham, AL

10/9/2012

“Chemoreflex Function in Heart Failure and It's Clinical Impact” Department of Physiology &

Neurobiology, Dartmouth School of Medicine, Lebanon, NH, 10/3/2012

“Carotid Body Function in Heart Failure” 6th European Congress of Pharmacology, Granada Spain,

7/18/2012

“Redox Pathways in Chemoreflex Function.” Redox Biology Center Mini-Symposium, University of

Nebraska, Lincoln, 9/23/2011

“Heart Failure and Carotid Body Chemoreception.” XVIIIth Meeting of the International Society for

Arterial Chemoreception. McMaster University, Hamilton ON, 7/14/2011.

“Chemoreflex Function in Heart Failure: Go With the Flow.” American Heart Association Scientific

Sessions, Nov, 2010.

“Plasticity of Carotid Body in Heart Failure and Its Pathophysiological Consequences.” In

Neuroplasticity of Autonomic Behavior in Health and Disease, Featured Topic, Experimental

Biology 2009, New Orleans, LA, 4/20/2009.

“Chemoreflex Abnormalities in Heart Failure: A Link Between Vascular and Autonomic

Dysfunction” 12th Annual Cardiovascular Research Symposium, UNMC, 2/2009


40

“Chemoreflex Function in Heart Failure” Division of Basic Biomedical Sciences, Sanford School of

Medicine, University of South Dakota, Vermillion, SD, 11/09

“Chemoreflex Dysfunction in Heart Failure: Cellular Mechanisms” Beijing Joint Conference of

Physiological Sciences 2008, Beijing, China, 10/2008

“What Does the Chemoreceptor Reflex Have to Do With Heart Failure or Redox Biology?” Dept. of

Biochemistry, Redox Biology Center, Univ. Nebraska, Lincoln, NE. 5/22/2008.

“Chemoreflex Effects on Sympathetic Nerve Activity in Heart Failure: A Feedforward System Gone

Awry” Neural Mechanisms in Cardiovascular Regulation, FASEB Summer Research Conference,

Sydney, Australia, 7/2007.

“Chemoreflex Dysfunction in Heart Failure: Multiple Mechanisms and Sites of Action” Department

of Population Health Sciences, University of Wisconsin, Madison, WI, 10/2006

“Chemoreflex Dysfunction in Heart Failure: Multiple Mechanisms and Sites of Action” Department

of Pharmacology, University of Texas San Antonio, San Antonio, TX, 9/2006

“Globins and Goblins and Porphyrin Potions: the Magic of Sensing Oxygen. Department of Cellular

& Integrative Physiology, UNMC. 10/2005

"Chemoreflex Activation in Heart Failure: Contribution to Sympathetic Hyperreactivity and Periodic

breathing." Redox Biology Center, University of Nebraska, Lincoln NE, 4/2004

“Oxidative Stress and Cardiac Afferents in Diabetes.” International Conference on Chest Diseases

and Allied Sciences. Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, 01/12-14/03

“Carotid Body Chemoreflex: Metamorphosis From Good to Bad in Heart Failure.” International

Conference on Chest Diseases and Allied Sciences. Vallabhbhai Patel Chest Institute, University of

Delhi, Delhi, 01/12-14/03

“Oxidative Stress and Cardiac Afferents in Diabetes.” Symposium on mechanisms of sensory

transduction. FASEB Summer Research Conference, Snowmass Co., 2002.


breathing." Feature topic on Chemoreflex Control of Cardiovascular Function in Health and

Disease”, Experimental Biology 2002


breathing." Pulmonary and Critical Care Medicine and Department of Physiology, University of

Louisville School of Medicine, Louisville, KY, 1/19/01.

"Chemoreflex Function in Heart Failure: friend or Foe?" Departments of Biomedical Sciences and

Pharmacology, Creighton University, Omaha, NE, 9/19/00.


breathing." Pulmonary and Critical Care Medicine, Harvard Medical School, Boston, MA, 9/13/00

"Cardiac Vagal Chemosensory Afferents: Function in Pathophyiological States." 2000 American

Physiological Society Conference: Baroreceptor and Cardiopulmonary Receptor Reflexes, Iowa

City, IA, 8/23/00

"Cardiopulmonary Dynamics Using MacLab as a Teaching Tool." Nebraska Physiological Society

Third Annual Meeting, Omaha, NE, 8/15/00


41

"Sympathetic Dysfunction in Heart Failure: Is NO the Answer?" Veterans Administration Hospital,

Omaha, NE. 1/14/00

"Heart Failure Activates peripheral Chemoreceptor Afferents and Chemoreflex Activity in a Rabbit

Model." The Sixth lnternational Symposium on Sleep and Respiration. Banff, Alberta, Can. 3/29,

1999

"Vitamin E improves cardiac chemoreflex function in streptozotocin induced diabetic rats."

University of Nebraska Medical Center Second Cardiovascular research Symposium. February 13,

1998.

"Activation of cardiac vagal afferents in ischemia and reperfusion" Poster presentation at the

Coleridge Symposium. Sacramento, CA. April 9, 1994.

"Sensory Function of the Heart" Joseph P. Gilmore Distinguished Basic Scientist Award Lecturer

University of Nebraska College of Medicine, Omaha, NE. August 24, 1993.

"Functional characteristics of arterial C-fiber endings" Department of Anatomy, University of

Nebraska Medical Center, Omaha, NE. February 3, 1992.

"ANP: Role in reflex regulation of sympathetic outflow" Department of Physiology, Creighton

University, Omaha, NE. October 15, 1990.

"HyperCardiac: Illustrating the cardiac cycle on the Macintosh computer using Hypercard" Eighth

National Symposium on Computers in Medical Education. April 6-7, 1991, Omaha, NE

"How research will affect the way we treat heart disease in the future" American Heart Association,

Nebraska Affiliate Delegate Assembly, Lincoln, NE. May 30, 1992.

"The protective function of C-fiber endings in the heart" Department of Physiology & Biophysics,

University of Louisville School of Medicine, Louisville, KY. December 6, 1994.

"Cardiac vagal afferent stimulation by free radicals during ischemia and reperfusion" Symposium:

Neural Control of the Circulation in Heart Failure (Cardiovascular Biology Theme) Experimental

Biology '95, April 12, 1995, Atlanta Georgia.

"The effects of ischemia and reperfusion on cardiac sensory endings: Roles of prostaglandins and free

radicals." Neural Control of the Circulation, Novel Control Mechanisms. 69th Scientific Sessions,

American Heart Association, November 9, 1996, New Orleans, LA.

F. CONTINUING EDUCATION MATERlALS

Schultz, H.D., and K. G. Cornish. Using computer and multimedia technology to demonstrate

physiological principles in the lecture hall. International Association of Medical Science Educators,

Washington, D.C., July 17-20, 1999.

Heidrick, M.L., and H.D. Schultz. Function of the human body: An integrated basic science course

with problem based learning. Basic Science Education Forum, American Association of Medical

Colleges, 1997.

Heidrick, M.L., and H.D. Schultz, Function of the human body: An integrated basic science course

with problem based learning. Basic Science Education Forum, American Association of Medical

Colleges, 1993.

Schultz, H.D. Demonstrating cardiovascular events using a macintosh computer and a chronically

instrumented dog. International Association of Medical Science Educators, Chicago, IL. June 26-29,

1995.


42

G. COMPUTER SOFTWARE

Goerke, J., H.D. Schultz, and E.D. Hon. The animated cardiac cycle: Illustrating form and function of

the heart on the Macintosh computer. The FASEB Journal 3: A1371, 1989.

Hon, E.D., J. Goerke, and H.D. Schultz. Vectorlab: an interactive computer presentation of

electrocardiographic fundamentals. The FASEB Journal 3: A1371, 1989.

Schultz, Goerke, and Hon have developed Hypercardiac , a set of three Hypercard® applications for

the Macintosh® computer that illustrate the cardiac cycle, electrocardiogram, and vector analysis of

the heart. This software is being distributed as freeware to educational institutions via Internet.

Cardiovascular demonstration developed on the Macintosh® computer using HyperCard® and

MacLab® software. This software package in conjuction with experimental manipulations on a

chronically instrumented dog was used to demonstrate cardiovascular function to the first year

medical students during the "Function of the Human Body" core

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