1 `Harvard Medical School Curriculum Vitae Date Prepared: December 26, 2017 Name: Alfred Eric Buxton Office Address: Beth Israel Deaconess Medical Center, 185 Pilgrim Road, West Campus-Baker 4 Work Phone: 617 632-9209 Work E-Mail: [email protected]Work FAX: 617 632-7620 Place of Birth: New York City, NY Education June,1969 AB Biology University of Rochester (High Distinction) May,1973 MD Medicine University of Pennsylvania Postdoctoral Training June1973-June1974 Intern Medicine Hospital of the Univ. of Pennsylvania July1974-June1975 Resident Medicine Hospital of the Univ. of Pennsylvania July1977-June1978 Resident Medicine Hospital of the Univ. of Pennsylvania July1978-June1980 Fellow Cardiology Hospital of the Univ. of Pennsylvania July1980-June1981 Fellow Cardiac Electrophysiology Hospital of the Univ. of Pennsylvania Faculty Academic Appointments July1974-June1975 Assistant Instructor in Medicine University of Pennsylvania Jan1976-June1977 Instructor in Medicine Emory University July1977-June1978 Assistant Instructor in Medicine University of Pennsylvania July1981-June1988 Assistant Professor of Medicine University of Pennsylvania July1988-Feb1993 Associate Professor of Medicine University of Pennsylvania Feb1993-July1999 Professor of Medicine and Cardiology Temple University Oct1999- April 2011 Professor of Medicine Brown University July2004-April 2011 Ruth and Paul Levinger Professor of Cardiology Brown University May 1, 2011- Lecturer on Medicine Harvard Medical School June 1, 2012- ` Associate Professor of Medicine Harvard Medical School February 1, 2014 Professor of Medicine Harvard Medical School Appointments at Hospitals/Affiliated Institutions
Transcript
1
`Harvard Medical School Curriculum Vitae
Date Prepared: December 26, 2017
Name: Alfred Eric Buxton
Office Address: Beth Israel Deaconess Medical Center, 185 Pilgrim Road, West Campus-Baker 4
Education June,1969 AB Biology University of Rochester (High Distinction) May,1973 MD Medicine University of Pennsylvania Postdoctoral Training June1973-June1974 Intern Medicine Hospital of the Univ. of Pennsylvania July1974-June1975 Resident Medicine Hospital of the Univ. of Pennsylvania July1977-June1978 Resident Medicine Hospital of the Univ. of Pennsylvania July1978-June1980 Fellow Cardiology Hospital of the Univ. of Pennsylvania July1980-June1981 Fellow Cardiac Electrophysiology Hospital of the Univ. of Pennsylvania
Faculty Academic Appointments July1974-June1975 Assistant Instructor in Medicine University of Pennsylvania
Jan1976-June1977 Instructor in Medicine Emory University
July1977-June1978 Assistant Instructor in Medicine University of Pennsylvania
July1981-June1988 Assistant Professor of Medicine University of Pennsylvania
July1988-Feb1993 Associate Professor of Medicine University of Pennsylvania
Feb1993-July1999 Professor of Medicine and Cardiology Temple University
Oct1999- April 2011 Professor of Medicine Brown University
July2004-April 2011 Ruth and Paul Levinger Professor of Cardiology Brown University
May 1, 2011- Lecturer on Medicine Harvard Medical School
June 1, 2012- ` Associate Professor of Medicine Harvard Medical School
February 1, 2014 Professor of Medicine Harvard Medical School
Appointments at Hospitals/Affiliated Institutions
2
Jan1976-June1977 Visiting Medical Staff -Cardiology Grady Memorial Hospital
July1977-June1979 Staff Physician in Student Health Hospital of the Univ. of Pennsylvania
July1981-Feb1993 Medical Staff Hospital of the Univ. of Pennsylvania
Feb1993-July1999 Medical Staff Temple University Hospital
Aug1999-April 2011 Medical Staff Rhode Island Hospital
Aug1999- April 2011 Medical Staff The Miriam Hospital
May 2011-present Medical Staff Beth Israel Deaconess Medical Center Other Professional Positions July1975-June1977 Epidemic Intelligence Service Officer, Centers for Disease Control, USPHS 1994-1999 Member, National Advisory Panel to National Institutes of Health CARD PORT “Sudden Cardiac Death” Stanford University School of Medicine (Mark Hlatky, PI) 2001 Workshop, “Sharing a Commitment to Improve ACC/FDA Cardiovascular Devices” – Chairperson, Committee on Postmarket Surveillance of ICDs 2003 Member, Medicare Coverage Advisory CMS Committee on ICD Utilization 2006-2007 Member, Global Advisory Board GE Healthcare 2006 Invited Reviewer - Scientific Statement on AHA/ACC/HRS Noninvasive Risk Stratification Techniques for Identifying Patients at Risk for Sudden Cardiac Death 2006- Member, Clinical Events Committee Cryocath/Medtronic Randomized Trial of Catheter Cryoablation to Treat Paroxysmal Atrial Fibrillation (“Stop AF”) 2009 Lead Reviewer, Expert Consensus Statement EHRA/HRS on Catheter Ablation for Ventricular Arrhythmias 2009 Member, Clinical Science Committee, NHLBI Workshop on Prediction and Prevention of Sudden Cardiac Death 2009-2017 Chairman, Data and Safety Monitoring Board, NHLBI CABANA Trial (Catheter Ablation Versus Anti-arrhythmic Drug Therapy for Atrial Fibrillation) 2011 Outside Quality Reviewer, University of New Mexico Electrophysiology Program Major Administrative Leadership Positions 1982-1983 Director, Arrhythmia Evaluation Center Hospital of the University of Pennsylvania (Cardiology Division) 1983-1993 Director, Clinical Electrophysiology Laboratory Hospital of the University of Pennsylvania
3
(Cardiology Division) 1993-1999 Associate Chief of Cardiology Temple University School of Medicine 1994-1999 Associate Director, Clinical Research Center Temple University School of Medicine 1997-1999 Director, Cardiology Fellowship Program Temple University School of Medicine 1998-1999 Director, Clinical Electrophysiology Laboratory Temple University School of Medicine 1999-April 2011 Director, Arrhythmia Services and Rhode Island and Miriam Hospitals Electrophysiology Laboratory 1999-April 2011 Director, Clinical Electrophysiology Fellowship Rhode Island Hospital Program 2004-April 2011 Director, Cardiology Division Rhode Island and Miriam Hospitals 2004-April 2011 Executive Director, Cardiology Division VA Medical Center, Providence, RI 2004-April 2011 Executive Director, Cardiology Division Memorial Hospital of Rhode Island May 2011- Director, Clinical Electrophysiology Laboratory Beth Israel Deaconess Medical Center May 2011- Director, Clinical Electrophysiology Fellowship Beth Israel Deaconess Medical Center Program July 2015- Director, ECG Laboratory Beth Israel Deaconess Medical Center Committee Service
1984-85, 87-88 Member, Admissions Interview Panel University of Pennsylvania School of Medicine
1994-1999 Member, Department of Medicine Committee Temple University School of Medicine on Appointments & Promotions 1994–1999 Member, Liaison Committee for Medical Temple University School of Medicine Education, Subcommittee on Clinical Science Departments 1995-1999 Member, General Clinical Research Center Temple University School of Medicine Advisory Committee 1996-1997 Member, Medical School Committee on Temple University School of Medicine Curriculum, Biostatistics and Epidemiology 1996-1997 Member, Medical School Strategic Temple University School of Medicine Planning Committee, Research 1997-1999 Member, Research Enterprise Advisory Temple University School of Medicine Committee 2002-2003 Member, Department of Medicine Brown Medical School Research Review Committee 2003-April 2011 Member, Department of Medicine Brown Medical School Promotions Committee 2005 Member, Search Committee for Director, Brown Medical School Department of Emergency Medicine 2008 Member, Search Committee for Director, Brown Medical School Cardiothoracic Surgery Program
4
Professional Societies 1983- Fellow, American College of Physicians (ACP) 1992 Author "Cardiac Arrhythmias", Cardiovascular Medicine Subcommittee, Medical Knowledge Self-Assessment Program (MKSAP X) 1983- Fellow, American College of Cardiology (ACC)
1999-2002 Member, ACC/AHA/ACP-ASIM Committee to Revise the 1995 Statement on Electrocardiography
2003-2006 Member, ACC/AHA/ESC Ventricular Arrhythmias and Sudden Cardiac Death Guidelines Writing Committee 2003- Chairman, ACC/AHA/HRS Committee on Electrophysiology Data
Standards 2005-2006 Chairman, ACC/HRS National ICD Registry Database Committee 2006-2013 Member, ACC/HRS National (CMS) ICD Registry Research and Publications Subcommittee
2009-2010 Member, ACCF/AHA Writing Committee Methods Paper on Developing Quality Indicators for Cardiovascular Technology
2009- Member, ACC/AHA Writing Committee on Data Standards and Definitions for Cardiovascular Electronic Health Record 2012-2013 External Reviewer, ACCF/HRS/AHA 2013 Appropriate Use Criteria
For Implantable Cardioverter-Defibrillators and Cardiac Resynchronization Therapy
2013-2014 AHA Representative to HRS/ACC/AHA Expert Consensus Statement on ICD Indications Outside of Current Guidelines Writing Group
2014 HRS Representative to Nuclear Cardiology Society Guidelines Committee for Use of MIBG Scanning
1985- Fellow, American Heart Association (AHA)
1994-1995 Member, Committee on Electrocardiography and Electrophysiology 1995-1997 Member, Committee on Electrocardiography and Arrhythmias
1996-1998 Council Representative for Southeast Pennsylvania-Council on Clinical Cardiology
1992-2002 Member, American Federation for Clinical Research 1990- Member, Heart Rhythm Society (HRS) (formerly North American
Society of Pacing and Electrophysiology) 1977- Diplomate, American Board of Internal Medicine
1998-2000 Member, Self Evaluation Process Committee for Clinical Cardiac Electrophysiology 2002-2004 Member, Recent Advances in Cardiology Self Evaluation Process Committee 2004-2005 Member, Self Evaluation Process Committee for Cardiology 2006-2012 Member, Test Writing Committee on Clinical Cardiac Electrophysiology
5
Grant Review Activities Year(s) of Membership Name of Committee Organization 1992 Ad hoc reviewer – Clinical Trials Board-ICD Trial NHLBI
2009 Ad hoc reviewer – Challenge Grants NHLBI
2009-2010 Ad hoc reviewer – K Award NHLBI
2010 Grant review member-Special Emphasis Panel NHLBI (SEP; ZRG1 BDCN-Y-02) 2013 Grant review member-Special Emphasis Panel NHLBI
(SEP – BMIT-A Committee)
2013 Clinical Trials Grant Reviewer Canadian Institutes of Health Research
Open Operating Grant Program, Randomized Controlled Trials Peer Review Committee
Editorial Activities
• Ad hoc Reviewer American Journal of Cardiology American Heart Journal
Annals of Internal Medicine Chest Circulation
Heart Rhythm Internal Medicine (Australia)
Journal of the American College of Cardiology Journal of the American College of Cardiology - Cardiovascular Imaging
Journal of the American Medical Association Journal of Cardiovascular Electrophysiology New England Journal of Medicine Pacing and Clinical Electrophysiology • Other Editorial Roles 1985-1990 Associate Editor Annals of Internal Medicine 1986-2008 Associate Editor American Journal of Cardiology 1991-1993 Editorial Board Member Circulation 1998- Editorial Board Member Journal of Cardiovascular Electrophysiology 2000-2005, 2011- Editorial Board Member Journal of the American College of Cardiology 2004- Editorial Board Member Heart Rhythm 2005- Editorial Board Member American Heart Journal 2007 Guest Editor Heart Rhythm 2007 Guest Editor Journal of the American College of Cardiology
6
2007, 2008 Guest Editor American Heart Journal 2014- Associate Editor Heart Rhythm (As one of 6 Associate
Editors I am responsible for managing review, revision, acceptance/rejection of 6-12 manuscripts submitted every week)
Honors and Prizes 1969 Phi Beta Kappa 1971 Alpha Omega Alpha 1973 Saunders Prize University of Pennsylvania School of Medicine Graduation 2002 Chairman’s Award for Outstanding Teaching Brown Medical School, Dept of Medicine 2002 Department of Medicine Beckwith Family Award for Outstanding Teaching Brown Medical School 2003 Dean’s Teaching Excellence Award – Brown Medical School Pathophysiology/Cardiovascular 2004 Dean’s Teaching Excellence Award – Brown Medical School Pathophysiology/Cardiovascular 2006 Outstanding Contribution Award ACC/HRS ICD Registry (Data Elements and Definitions) 2006 Dean’s Teaching Excellence Award – Brown Medical School Pathophysiology/Cardiovascular 2007 Dean’s Teaching Excellence Award – Brown Medical School Pathophysiology/Cardiovascular (Small Group) 2008 “Development Mission of the Heart” Award American Heart Association 2009 Certificate of Recognition-Exemplary Teaching in Brown Medical School CV Pathophysiology BIOL 3662 IMS III:Small Group 2010 Dean’s Excellence in Teaching Award Brown Medical School CV Pathophysiology BIOL 3662 IMS III:Small Group 2011 Certificate of Recognition-Exemplary Teaching in Brown Medical School CV Pathophysiology BIOL 3662 IMS III:Small Group 2012 Simon Dack Award for Outstanding Scholarship – American College of Cardiology 2012 First Year Cardiology Fellows’ Excellence in Teaching Award Beth Israel Deaconess Medical Center 2014 Elite Reviewer, Journal of the American College of Cardiology 2014 Harvard University, Master of Arts, Honorary 2016 First Year Cardiology Fellows’ Excellence in Teaching Award Beth Israel Deaconess Medical Center 2017 First Year Cardiology Fellows’ Excellence in Teaching Award Beth Israel Deaconess Medical Center Report of Funded and Unfunded Projects Funding Information Past Funding 1980-81 PI NIH F32 HL06201-01
7
Mechanisms of Nonsustained Ventricular Tachycardia
Electrophysiologic testing was performed in patients with spontaneous non-sustained ventricular tachycardia using a variety of stimulation techniques and pharmacologic manipulation to elucidate mechanisms underlying tachycardia. I performed this study.
Electrophysiologic testing and mapping of right and left ventricular endocardium was performed during sinus rhythm and ventricular tachycardia. Patients with a variety of clinical arrhythmias were studied to characterize substrate requirements to support ventricular tachycardia and fibrillation.
This was a training grant devoted to training clinical electrophysiologists.
1993-1998 Site PI NIH N01-HC-25117 aproximately $8000/yr
Implantable Cardiac Defibrillators versus Antiarrhythmic Drug Therapy
This was a multicenter randomized, controlled clinical trial comparing effects of ICDs versus amiodarone or sotalol on total survival in patients with spontaneous ventricular fibrillation and other life-threatening arrhythmias (the AVID Trial).
1991-1998 PI NIH 1 UO1-HL45700 $7,460,386. total award.
Randomized Trial of Electrophysiologically Guided Therapy in Patients with Nonsustained Ventricular Tachycardia, Left Ventricular Dysfunction and Coronary Artery Disease
This was a randomized controlled clinical trial evaluating the utility of clinical electrophysiologic studies to guide therapy of patients with coronary disease, ejection fraction ≤40% and spontaneous non-sustained ventricular tachycardia (The MUSTT Trial).
1999-2001 Site PI NIH
Sudden Cardiac Death in Heart Failure: Trial of Prophylactic Amiodarone or Implantable Defibrillator Therapy vs. Placebo (SCD-HeFT)
2001-2003 Site PI Medtronic, Inc.
PainFreeRxII Trial – A randomized controlled trial comparing efficacy of antitachycardia pacing to shock therapy for patients with ICDs.
8
2001-2007 Member Executive Committee and Site PI CIHR MCT41552
Rhythm control versus rate control for atrial fibrillation and heart failure (AF-CHF)
This was a multicenter, randomized controlled trial comparing mortality in patients with atrial fibrillation and heart failure treated with either rate control or rhythm control.
2003-2007 Site PI St. Jude Medical
The dual chamber and VVI implantable defibrillator trial II (DAVID II) – A randomized controlled trial outcomes in patients receiving ICDs comparing atrial pacing to backup ventricular pacing.
2004-2006 PI Medtronic, Inc. $20,000/yr
INSIGHT Registry of ICD Utilization
This was a prospective multicenter registry evaluating factors relating to ICD implant in general practice.
2006-2011 Site PI Bristol-Myers Squibb
ARISTOTLE – Randomized controlled trial of apixaban vs. warfarin in patients with atrial fibrillation at high risk of stroke.
2008-2010 Site PI C.R. Bard,Inc.
MAGELLAN – Trial of a novel MESH catheter for ablation of atrial fibrillation
Effects of Exercise on Autonomic Nervous System Tone in Patients with Implanted Defibrillators
This is a single center randomized trial to study effects of an exercise training program on measures of autonomic nervous system tone in patients with structural heart disease and implanted ICDs.
2008-2010 PI Rhode Island Medical Imaging Society $30,000.
Structure-function relations in ventricular tachyarrhythmias in patients with coronary disease
This was a study using cardiac MR to characterize the anatomic substrate underlying ventricular tachycardia and fibrillation in patients with prior MI.
Preventing Sudden Cardiac Death: Harnessing the Power of Decision Analysis, Bayesian Techniques, and Clinical Trials To enhance the ability of the AHRQ to provide evidence-based decision making tools to aid providers and policymakers in the prevention of sudden cardiac death.
9
This was a study devoted to developing an improved model(s) to predict patients at risk for sudden death.
2013 PI Medtronic, Biosense-Webster $115,000 Endocardial Mapping to Predict Response To Cardiac Resynchronization Therapy A prospective study characterizing ventricular activation in patients with left bundle branch block who meet current criteria for cardiac resynchronization therapy (CRT). The purpose is to correlate left ventricular activation patterns with response to CRT.
2013 Co-I NHLBI R34 HL107733-01A1 5% FTE Positive Psychotherapy to Improve Autonomic Function and Mood in ICD Patients This is a randomized controlled trial (Pilot phase) to assess the feasibility and acceptability of a 3-month quality of life, positive cognitive behavioral therapy intervention among a sample of cardiac patients with ICDs. Endpoints are quality of life, and incidence of ventricular arrhythmias.
Current Funding 2016-19 Co-I DHHS Agency for Health Care Policy and Research R01 HS024520-01 5% FTE Novel Statistical Methods to Study Heterogeneity in Treatment Effect This is an analysis of outcome events of patients enrolled in the MADIT-II and MUSTT trials and the Regenstreif Database at Indiana University. The major purpose of the study is to help develop a risk stratification model to describe and predict mortality of recipients of implantable cardioverter-defibrillators. 2016-2020 Co-I NHLBI 5R21HL127650 5% FTE MRI Characterization of arrhythmogenic scar in ventricular tachycardia In this study we will use CMR to analyze characteristics of scar in patients with sustained VT, using advanced CMR imaging protocols in order to better understand anatomic correlates of functional abnormalities underlying (mostly) reentrant VT.
This is a prospective study of patients receiving ICDs for primary prevention of sudden death to develop a model to identify patients most likely to exhibit survival benefits from ICDs. It’s previous score was 22. We submitted a revised application March 5, 2016, that was not funded. I am preparing a new application for a randomized controlled trial.
Current Unfunded Projects
10
2012 – ongoing PI Supervising Jakub Sroubek, MD ((BIDMC Cardiology Fellow) -prospective study of contribution of BNP and LV remodeling (as measured by a novel echocardiographic measure of LV remodeling we have developed – sphericity index) to development of spontaneous VT and VF in patients with abnormal LV function receiving ICDs for the primary prevention of sudden cardiac death 2016- ongoing PI Supervising Derin Tugal, MD (BIDMC Cardiac EP Fellow) on a comparison of sphericity index measured by MRI versus echocardiography Report of Local Teaching and Training Teaching of Students in Courses 1975-1976 Introductory Physical Diagnosis – Emory University School of Medicine Medical Students -1st year Instructor 4 students, 4 months, 1 day/week 1983-1990 ID 205, Applied Physiology – University of Pennsylvania School of Medicine Medical Students - 2nd year Instructor Approximately 30 students per year 1981-1986 Medicine 314A – Elective - University of Pennsylvania School of Medicine Medical Students – 3rd,4th year Instructor 3-4 students throughout each year
1984-1992 AE-250 Advanced Cardiac Life Support- University of Pennsylvania School of Medicine
Medical Students - 3rd, 4th year Lecturer 1 hour yearly, approximately 30 students 1992 Bridge Curriculum- Pathophysiology- Mechanisms of Tachyarrhythmias University of Pennsylvania School of Medicine Medical Students-2nd year Lecturer 1 hour 1994-1995 Introductory Physical Diagnosis Course - Temple University School of Medicine Medical Students-1st year Instructor 5 months/year, 4 students 1999 Mechanisms of Cardiac Arrhythmias - Temple University School of Medicine Medical Students-2nd year Lecturer 2 hours 2001-2011 Intro to Electrophysiology, the ECG, and Arrhythmias – Brown Medical School Medical Students-2nd year Lecturer total 6-8 hours lecture/year 2005 Doctoring Course – Ventricular Premature Complexes- Brown Medical School Medical Students-1st year Lecturer 1 hour 2006 Special Lecture: VT/VF and Implanted Defibrillators- Brown Medical School Medical Students-2nd year Lecturer 1.5 hours 2005--2010 Biol 3662-Pathophysiology – Small Group Sessions - Brown Medical School Medical Students-2nd year Small Group Leader 4 sessions of 3 hours, 8 students
11
2007-2010 Biol 0126 - Physiological Pharmacology Brown University Undergraduate Students Lecturer 1.5 hours/year August 2011 Intro to the ECG and Arrhythmias Brown Medical School Medical Students-2nd year Lecturer 2 hours lecture 2011-2012 Intro.Human Physiology – Electrophysiology 2 Harvard Medical
School Medical Students -1st year Lecturer 1.2 hours/year
2013 Introduction to Medicine-Cardiovascular Physical Exam Harvard Medical School Medical Students-2nd year Small Group Leader 2.5 hours/year 2015 – ongoing I mentor/supervise 2-3 2nd year HMS student every year in my clinical EP clinic
Formal Teaching of Residents, Clinical Fellows and Research Fellows (post-docs) 1995-1999 ECG Interpretation Lecture Series - Temple University Hospital 12 fellows 10 months/year, 1 hour weekly 2000-April 2011 Lecturer – Medicine Housestaff Training Program-Brown Medical School Medical Interns, Residents 9 lectures yearly, 1 hour each 1999-2005, 2008-2009 Lecturer- Rhode Island Hospital Emergency Department Residents 3 lectures yearly, 1 hour each 2002-April 2011 Lecturer - Cardiology Training Program- Rhode Island Hospital Cardiology Fellows 3 one hour lectures yearly 2002- April 2011 Instructor ECG Interpretation – Cardiology Training Program – Rhode Island
Hospital Cardiology Fellows 1 hour weekly 2011- Instructor ECG Interpretation –Beth Israel Deaconess Medical Center Cardiology Fellows 1 hour weekly 2011- Lecturer-Arrhythmias - Beth Israel Deaconess Medical Center Cardiology Fellows 3 hours yearly 2011- Lecturer-Arrhythmias- Beth Israel Deaconess Medical Center Clinical electrophysiology Fellows 6 hours yearly
12
Clinical Supervisory and Training Responsibilities 1981-1993 Director, Arrhythmia Evaluation Center-Hospital of the Univ. of Pennsylvania Supervise Clinic ½ day weekly 1981-1993 Attending – Cardiology Consult Service-Hospital of the Univ. of Pennsylvania 2 months/year, daily teaching rounds 1981-1993 Attending – Clinical Electrophysiology Lab-Hospital of the Univ. of Pennsylvania 9 months/year, daily Provide hands-on procedure training for clinical EP fellows 1993-1999 Attending-Cardiology Clinic – Temple University Hospital Supervise Clinic ½ day weekly 1993-1999 Attending – Clinical Electrophysiology Lab- Temple University Hospital 9 months/year, daily Provide hands-on procedure training for clinical EP fellows 1995-1999 Attending – Cardiology Consult Service- Temple University Hospital 3 months/year, daily teaching rounds 2006-2008 Teaching Attending, General Medical Service-Rhode Island Hospital daily teaching rounds, 1 month yearly 1999-April 2011 Attending – Clinical Electrophysiology Lab- Rhode Island Hospital 10 months/year, 1-2 days/week Provide hands-on procedure training for clinical EP fellows May 2011- Attending - Clinical Electrophysiology Lab –Beth Israel Deaconess Medical
Center 2 days/week Provide hands-on procedure training for clinical EP fellows May 2011-2013 Attending physician- CCU – Beth Israel Deaconess Medical Center Medicine Residents and Cardiology Fellows 3-4 weeks/year May 2011- Attending physician – Clinical Electrophysiology Inpatient Consult Service Clinical EP fellows, Cardiology Fellows, Medical Residents, Students 8 weeks/yr May 2011- Attending – Clinical Electrophysiology Clinic Beth Israel Deaconess Medical
Center Clinical EP Fellows ½ day/week 2011 - Attending physician- Electrophysiology Consult Service – Beth Israel Deaconess
Medical Center Medicine Residents and Cardiology Fellows 8 weeks yearly 2014- Attending physician- Zoll Inpatient Service – Beth Israel Deaconess Medical
Center
13
Medicine Residents and Cardiology Fellows 2 weeks yearly 2014- Attending physician- Cardiology Consult Service – Beth Israel Deaconess
Medical Center Medicine Residents and Cardiology Fellows 2 weeks yearly Formally Supervised Trainees
Since 1981 I have formally supervised and mentored 2-4 clinical cardiac electrophysiology fellows every year. I have trained approximately 50 fellows. While the majority of these have taken positions in practice, a number have gone on to successful academic careers in which they are recognized nationally and internationally, including Denis Roy, MD (Montreal Heart Institute); Jesus Almendral, MD (Madrid); Bruce Lerman, MD (Cornell Medical Center); John Miller, MD (Indiana University); David Callans, MD (University of Pennsylvania); William Balke (University of Maryland; Ohad Ziv, MD (Case Western Reserve (Metro Health); Daniel Kramer, MD (BIDMC/HMS); Yehoshua Levine, MD (Univ. of Tennessee), Jonathan Waks, MD (BIDMC/HMS), Fernando Contreras, MD (BIDMC/HMS), Daniel Steinhaus, MD (University of Kansas/Mid-America Heart Institute).
Formal Teaching of Peers (e.g., CME and other continuing education courses)
I delivered lectures at Medical Grand Rounds at Rhode Island Hospital approximately twice every year. I delivered 1-2 lectures at Cardiology Grand Rounds Rhode Island Hospital every year from 2000-April 2011 April, 1982 Philadelphia, PA Lecturer Tachycardias: Mechanisms, Diagnosis, and Treatment, sponsored by The University of Pennsylvania School of Medicine and the University of Limburg, Maastricht November, 2011 Boston, MA Lecturer Medical Grand Rounds – Beth Israel Deaconess Medical Center Current Epidemiology and Mechanisms of Sudden Cardiac Death December 2014 Boston, MA Lecturer Medical Grand Rounds – Beth Israel Deaconess Medical Center Current Approaches to Risk Stratification for Sudden Cardiac Death
Local Invited Presentations
1. December 2,1983 “Antiarrhythmic drugs-present and future” Coatesville, PA Cardiology Rounds, Brandywine Hospital 2. May 12, 1984 “The role of electrophysiologic techniques in the selection of
antiarrhythmic
14
Reading, PA agents for ventricular arrhythmias” Cardiology Rounds, St. Joseph’s Hospital 3. December 10, 1985 "Surgical approaches to Ventricular Tachycardia." Philadelphia, PA Cardiology Conference Medical College of Pennsylvania 4. December 18, 1985 "Sudden Death." Philadelphia, PA Clinical Pathologic Conference Temple University Hospital 5. January 29, 1986 "Rationale for treatment of Ventricular Tachycardia." Philadelphia, PA Cardiology Conference Albert Einstein Medical Center 6. October 17, 1986 "Sudden Death." Philadelphia, PA Medical Grand Rounds Graduate Hospital 7. October 17, 1986 "Sudden Death." Hazleton, PA Cardiology Grand Rounds St. Joseph's Medical Center 8. February 3, 1988 "Life threatening arrhythmias." Reading, PA Grand Rounds Reading Hospital 9. October 14, 1988 "Identification of patients at risk for sudden cardiac death." Caln Township, PA Medical Grand Rounds Brandywine Hospital 10. July 3, 1991 "Management of Nonsustained Ventricular Tachycardia." Philadelphia, PA Medical Grand Rounds University of Pennsylvania 11. December 3, 1991 "Electrophysiology of the Heart." Abington, PA Medical Grand Rounds Abington Memorial Hospital 12. January 4, 1992. "Therapy: Non-Pharmacological."
Philadelphia, PA Symposium: Supraventricular Arrhythmias: Clinical Perspectives and Management
13. February 21, 1992 "Treatment of Ventricular Arrhythmias." Reading, PA Medical Grand Rounds St. Joseph's Hospital 14. February 21, 1992 “Mechanisms of Nonsustained Ventricular Tachycardia." Philadelphia, PA Medical Grand Rounds Temple University Hospital 15. April 22, 1992 "Treatment Methods and Modalities for Supraventricular Arrhythmias.” Philadelphia, PA Cardiology Grand Rounds, Albert Einstein Medical Center 16. September, 1992 Clinical Electrophysiology: Cardiovascular Board Review, presented by Philadelphia, PA The American College of Cardiology, Pennsylvania Chapter Likoff Cardiovascular Institute, and Hahnemann University Hospital 17. October 8, 1992 "Treatment of Ventricular Tachycardia - Post Myocardial Infarction." Philadelphia, PA Medical Grand Rounds, Episcopal Hospital 18. December 8, 1992 "NSVT: What is its Clinical Significance." Philadelphia, PA Cardiology Grand Rounds, Medical College of Pennsylvania 19. January 5, 1993 "Ventricular Tachycardia." Philadelphia, PA Visiting Professor, Methodist Hospital 20. November 24, 1993 "Evaluation of the Patient with Nonsustained VT." Philadelphia, PA Cardiology Grand Rounds, Lankenau Hospital 21. March 10, 1994 "The relation of nonsustained VT to Sudden Death after Myocardial Bryn Mawr, PA Infarction." Medical Grand Rounds, Bryn Mawr Hospital 22. March 18, 1994 "Arrhythmias in the Elderly" Lancaster, PA Temple University Geriatric Board Review Course 23. December 10, 1994 "Management of Arrhythmias in Patients with Congestive Heart Failure." Philadelphia, PA Symposium: Cardiac Transplantation and the Management of End-Stage Heart
15
Failure in the 1990s, Temple University School of Medicine 24. April 12, 1995 "Mechanisms of Sudden Death in Ischemic Heart Disease" Philadelphia, PA Cardiology Grand Rounds, Presbyterian Medical Center 25. March 8, 1996 "The spectrum of ventricular arrhythmias in coronary artery disease." Camden, NJ Cardiology Grand Rounds, Cooper Hospital/University Medical Center 26. April 12, 1996 "Approach to the Patient with Coronary Disease and Ventricular Philadelphia, PA Tachycardia." Cardiology Grand Rounds, Hahnemann University 27. November 13, 1996 "Treatment of Ventricular Arrhythmias in Patients with Coronary Artery Philadelphia, PA Disease." Medical Grand Rounds, Temple University School of Medicine 28. December 10, 1996 "Mechanisms of Sudden Death in Patients with Coronary Artery Langhorne, PA Disease." Medical Grand Rounds, St. Mary’s Medical Center 29. April 3, 1998 "Management of Atrial Fibrillation." Philadelphia, PA Medical Grand Rounds, Germantown Hospital 30. November 17, 2011 “Sudden Cardiac Death – Mechanisms, Risk Stratification” Boston, MA Medical Grand Rounds Beth Israel Deaconess Medical Center 31. November 15, 2012 “Risk Stratification - Sudden Death” Boston, MA Electrophysiology Teaching Conference Brigham & Women’s Hospital 32. August 28, 2013 “Arrhythmias and the Anesthesiologist” Boston, MA Anesthesia Grand Rounds Beth Israel Deaconess Medical Center 33. September 5, 2013 “Risk Stratification for Sudden Cardiac Death” Burlington, MA Cardiology Grand Rounds Lahey Clinic 34. October 7, 2013 “Sudden Cardiac Death-Historical Perspectives on Risk Stratification”” Boston, MA Electrophysiology Conference Massachusetts General Hospital 35. October 16, 2013 “Recognition of Risk for Sudden Death-Current Perspectives” Boston, MA Cardiology Grand Rounds Massachusetts General Hospital 36. April 15, 2015 “Approach to Management of Sudden Cardiac Death” Brockton, MA Signature Healthcare Brockton Hospital 37. December 11, 2014 “Sudden Cardiac Death” Boston, MA Update in Internal Medicine, sponsored by BIDMC 38. December 10, 2015 “Sudden Cardiac Death” Boston, MA Update in Internal Medicine, sponsored by BIDMC 38. March 22, 2017 “Arrhythmias and Sudden Death in End-Stage Renal Disease” Boston, MA Nephrology-2017, sponsored by BIDMC Report of Regional, National and International Invited Teaching and Presentations Regional Invited Presentations 1. April 13, 1983 "Electrophysiological approach to the management of ventricular tachycardia." Newark, NJ Medical Grand Rounds St. Michael's Medical Center 2. October 26, 1984 "Ventricular tachycardia." Lansdale, PA Medical Grand Rounds North Penn Hospital
16
3. December 5, 1984 "Cardiac mapping." Harrisburg, PA Annual Meeting, American College of Cardiology, Pennsylvania Affiliate 4. December 18, 1984 "The Long QT Syndrome." Bethlehem, PA Cardiology Grand Rounds, St. Luke's Hospital 5. March 20, 1985 "Ventricular Tachycardia." Medical Grand Rounds Reading, PA Cardiology Grand Rounds, The Reading Hospital and Medical Center 6. March 28, 1985, "Arrhythmias in the geriatric patient: new concepts and current therapy."
Lancaster, PA Cardiology Grand Rounds, Lancaster General Hospital 7. November 6, 1990 "Nonsustained ventricular tachycardia."
Princeton, NJ Medical Grand Rounds, The Medical Center at Princeton 8. January 22, 1991 "Current perspectives in antiarrhythmic therapy"
Doylestown, PA Medical Grand Rounds, Doylestown Hospital 9. May 7, 1992 "Treatment Methods and Modalities for Supraventricular Arrhythmias." Browns Mills, NJ Grand Rounds Deborah Heart & Lung Center 10. May 14, 1992 "Management of NSVT." Wayne, NJ Medical Grand Rounds Wayne General Hospital 11. October 23, 1993 "The Management of Patients with Nonsustained VT." Wilmington, DE Annual Scientific Sessions AHA, Delaware Affiliate 12. February 24, 1994 "Prevention of Sudden Death After Myocardial Infarction." Long Branch, NJ Medical Grand Rounds, Monmouth Medical Center 13. April 20, 1995 "The Relationship of Nonsustained VT to Sudden Death in Ischemic Pittsburgh, PA Heart Disease." Allegheny General Hospital 14. December 11, 1996 "Ventricular Arrhythmias After Myocardial Infarction - Contrasts and Johnstown, PA Comparisons." Medical Grand Rounds, Conemaugh Memorial Medical Center 15. December 22, 1999 “Prevention of Sudden Death in Patients with Coronary Artery Disease.” Boston, MA Cardiology Grand Rounds, Massachusetts General Hospital 16. February 8, 2000 “Primary Prevention of Sudden Death in Patients with CAD.” Hartford, CT Visiting Professor, Hartford Hospital 17. February 10, 2000 “Prevention of Sudden Death - Clinical Approaches.” Hartford, CT Cardiology Conference, St. Francis Hospital 18. March 29, 2000 “Primary Prevention of Sudden Death” Portland, ME Medical Grand Rounds, Maine Medical Center 19. March 31, 2000. “Primary Prevention of Sudden Death in 2000: ICDs? Drugs?” Springfield, MA Annual Symposium, Baystate Medical Center 20. February 22, 2001 “Prevention of Sudden Death After MI – Results of recent Trials” West Roxbury, MA Cardiology Grand Rounds, Veterans Administration Hospital 21. October 24, 2003 “Mechanisms and Prevention of Sudden Death in Patients with Coronary Boston, MA Artery Disease”. Cardiology Grand Rounds, Beth Israel/Deaconess Medical Center 22. January 27, 2005 “Does Everyone with Heart Disease Need an ICD?” Boston, MA Cardiology Grand Rounds, Brigham and Womens’ Hospital 23. February 2, 2009 “Current Approaches to Risk Stratification for Sudden Death” Boston, MA Electrophysiology Conference, Massachusetts General Hospital 24. May 19, 2010 “Evaluation of Risk for Sudden Death.” Worchester, MA Cardiology Grand Rounds, University of Massachusetts Medical Center 25. June 1, 2010 “Update on prevention of sudden cardiac death – structure/function
17
Boston, MA relations” Electrophysiology Conference, Massachusetts General Hospital 26. October 22, 2010 “Risk Stratification for Sudden Cardiac Death.” Boston, MA Mark E. Josephson Guest Lecture, Beth Israel Deaconess Medical Center 27. October 18, 2011 “Risk Stratification for Sudden Death – Current Approaches” Hartford, CT Cardiology Grand Rounds, Hartford Hospital 28. 2012 - Risk Stratification for Sudden death – annual lecture to Massachusetts
General Hospital Clinical Electrophysiology Service National Invited Presentations 1. March 23, 1982 “Sudden cardiac death”, and “Reentrant cardiac arrhythmias” Louisville, KY Kentucky Medical Association and Kentucky Chapter, American College
of Physicians 2. April 7, 1983 “Electrophysiologic approach to ventricular tachycardia” Brooklyn, NY Medical Grand Rounds, Coney Island Hospital, 3. December 8, 1983 “Management of intractable ventricular arrhythmias” Syracuse, NY Cardiology Grand Rounds Upstate Medical Center, 4. September 6, 1984 “Role of electrophysiologic studies in identifying arrhythmogenic Bethesda, MD properties of antiarrhythmic drugs.”
National Institutes of Health Symposium 5. October 5, 1984 “Nonsustained ventricular tachycardia: prognosis and treatment” Hartford, CT Cardiology Grand Rounds, Hartford Hospital 6. October 19, 1984 “Cardiac arrhythmias: New perspectives in assessment and treatment – St. Louis, MO 1984 Update” Cardiology Grand Rounds, St. Louis University Medical Center 7. February 26, 1985 “Surgery for ventricular tachycardia.” Valhalla, NY Cardiology Grand Rounds, New York Medical College 8. April 30, 1985 “Surgery for Ventricular Tachycardia.” New Orleans, LA Annual Meeting American Association for Thoracic Surgery 9. December 4, 1985 “Ventricular Tachycardia.” Portland, ME Medical Grand Rounds Maine Medical Center 10. January 14, 1986 “Nonsustained ventricular tachycardia - mechanism & Valhalla, NY Management.” Medical Grand Rounds New York Medical College 11. June 18-19, 1986 “Cardiac electrophysiologic studies in patients with nonsustained Iowa City, IA ventricular tachycardia” and “Atrial fibrillation and flutter: Insights from the clinical EP lab.” Cardiology Conference University of Iowa 12. November 8, 1986 “Nonsustained ventricular tachycardia” and “Non-pharmacologic Washington, DC treatment of ventricular arrhythmias.” Cardiology Conference, George Washington University Medical Center 13. December 2, 1986 “Sudden Death.” Valhalla, NY Cardiology Grand Rounds New York Medical College 14. February 6-7, 1987 “The role of the electrophysiologic test in the diagnosis and management
18
Dallas, TX of ventricular tachyarrhythmias.” Ventricular Tachycardia Arrhythmia Update Symposium 15. September 10, 1987 “Ventricular Tachycardia.” Brooklyn, NY Medical Grand Rounds Coney Island Hospital 16. January 12, 1988 “Evaluation of risk for sudden death.” Oceanside, NY Medical Grand Rounds South Nassau Community Hospital 17 May 17, 1988 “Ventricular tachycardia.” Valhalla, NY Grand Rounds West Chester County Medical Center 18. September 15, 1988 “Sudden Cardiac Death.” Bethesda, MD Medical Grand Rounds Bethesda Naval Hospital 19. April 6, 1990 “Nonsustained ventricular tachycardia.” Hartford, CT Cardiology Grand Rounds Hartford Hospital 20. May 10, 1990 “Identification of patients at risk for sudden cardiac death.” Green Bay, WI Eighth Annual Cardiology Seminar Bellin Memorial Hospital 21. February 4, 1991 “Ventricular arrhythmias.” Springfield, MA Medical Grand Rounds, Bay State University Medical Center 22. March 19, 1991 “Pharmacologic therapy for ventricular tachyarrhythmias and patients at Springfield, IL risk for sudden cardiac death.” Medical Grand Rounds, Southern Illinois University Hospital 23. May 4, 1991 “Management of Nonsustained Ventricular Tachycardia.” Bronx, NY Medical Grand Rounds, Montefiore Medical Center 24. May 8, 1991 “When and how to treat nonsustained ventricular tachycardia.” Worchester, MA Cardiology Grand Rounds, University of Massachusetts 25. May 16, 1991 “Nonsustained ventricular tachycardia - Co-conspirator or innocent New York, NY bystander” New York Cardiology Fellows Society Debate 26. December 4, 1991 “Therapy for SVA: Treatment Methods and Modalities.” Washington, DC Medical Grand Rounds Washington Hospital Center 27. December 7, 1991 “Mechanisms and Non-Pharmacological Therapy.” New York, NY Symposium - Supraventricular Arrhythmias: Clinical Perspectives and
Management Columbia University 28. February 7, 1992 “Nonsustained Ventricular Tachycardia - Significance, Management and Boston, MA Current Clinical Trials. » Symposium: Future Directions in the Treatment of Cardiac Arrhythmias 29. February 25, 1992 “The MUSTT Study.” Bronx, NY Cardiology Grand Rounds Montefiore Medical Center 30. March 11, 1992 “Sudden Cardiac Death After Myocardial Infarction: Who is at risk, What Garden City, NY can we do?” Cardiology Update American Heart Association, Nassau Region 31. April 3, 1992. “Nonsustained ventricular tachycardia - clinical significance, Providence, RI mechanisms, and management.” Cardiology Grand Rounds, Rhode Island Hospital - Brown University 32. April 24, 25, 1992 “Implantable Cardioverter Defibrillators: Era of Improved Technology Sacramento, CA. and Expanded Indications, Role of Anti-arrhythmic Medications – Amiodarone Prolongs Survival.”
Fifth Annual Scientific Session of Advances in Arrhythmia Management and Cardiac Pacing Mercy Heart Institute
33. May 6, 1992 “Arrhythmias - To treat or not to treat.”
19
Brooklyn, NY Samuel Epstein Lecture Coney Island Hospital 34. May 13, 1992 “The MUSTT Study.” Chicago, IL AICD Clinical Symposium 35. June 2, 1992 “Nonsustained VT: Who and How to Treat.” Chicago, IL Clinical Tutorial, North American Society of Pacing and Electrophysiology 36. June 3, 1992 “Drug Therapy for Ventricular Arrhythmias.” Cromwell, CT Pacing & Electrophysiology Symposium 37. June 26, 1992 “Treatment Methods and Modalities for Supraventricular Arrhythmias.” New Haven, CT Cardiology Grand Rounds, Yale University School of Medicine 38. August 22, 1992 “Issues in Arrhythmia Management: What Constitutes Appropriate Lake George, NY Therapy in 1992? - What Constitutes Prognostically Significant Ventricular Ectopy?” Columbia University Symposium 39. September 9, 1992 “Non-Sustained VentricularTachycardia.” Burlington, VT Cardiology Grand Rounds, University of Vermont 40. October 3, 1992 “Post Infarction Ventricular Ectopy: Who to Treat.” Waterville Valley, NH Annual Scientific Session: AHA, New Hampshire Affiliate 41. October 22, 1992 “From PVC To Sudden Death.” Brooklyn, NY Medical Grand Rounds, Coney Island Hospital 42. December 3, 1992 “The Significance of Nonsustained Ventricular Tachycardia after New York, NY Myocardial Infarction.” Cardiology Grand Rounds, New York University Medical Center 43. February 9, 1993 “Standardized Reporting of of ICD Patient Outcome” , “An Appropriate Bronx, NY Definition of Sudden Death.”
North American Society of Pacing and Electrophysiology Policy Conference Montefiore Medical Center
44. March 16, 1993 “Monomorphic VT in Chronic CAD.” Anaheim, CA American College of Cardiology, Symposium on Ventricular Tachycardia
Mechanisms and Therapy 45. May 7, 1993 “The Spectrum of Approaches to Nonsustained VT.”
San Diego, CA Meet the Experts Panel North American Society of Pacing and Electrophysiology 46. May 8, 1993 “The MUST Trial.” San Diego, CA North American Society of Pacing and Electrophysiology 47. May 15, 1993 “Mechanisms of Sudden Death in Patients with Coronary Artery Omaha, NE Disease.” Cardiology Grand Rounds University of Nebraska Medical Center 48. June 3, 1993 “Mechanisms and Significance of Nonsustained VT in the Post-infarction Boston, MA Patient.” Cardiology Grand Rounds, Beth Israel Hospital 49. June 10, 1993 “Mechanisms and Treatment of Supraventricular Tachycardia. Worchester, MA Cardiology Grand Rounds, University of Massachusetts 50. July 8, 1993 “Approaches to Prevention of Sudden Cardiac Death after Acute Albuquerque, NM Myocardial Infarction.” Medical Grand Rounds, University of New Mexico 51. July 16, 1993 “The MUSTT Trial.” Albany, NY Cardiology Conference, Albany Medical College
20
52. September 9, 1993 “Mechanisms of Sudden Cardiac Death”, “Methods to screen for risk of Boston, MA Sudden Death.” Symposium on Sudden Cardiac Death, Beth Israel Medical Center 53. September 30, 1993 “Prevention of Sudden Death After Myocardial Infarction – The MUST Trial” Mineola, NY Cardiology Conference, Winthrop University Hospital 54. October 20, 1993 “Mechanisms and Clinical Significance of Nonsustained VT.” Houston, TX Houston EP Society 55. October 21, 1993 “Mechanisms and Pharmacological Treatment of Supraventricular Houston, TX Tachycardia.” Cardiology Grand Rounds, University of Texas Medical Center 56. November 9, 1993 “Electrophysiologic Studies in the Evaluation of Syncope.” Atlanta, GA American Heart Association Cardiovascular Conference 57. December 15, 1993 “Prediction of Risk for Sudden Death in the Patient with Coronary Artery Valhalla, NY Disease.” Medical Grand Rounds New York Medical College 58. January 29, 1994 “Mechanisms and Management of Nonsustained Ventricular Portland, ME Tachycardia” Annual Scientific Sessions AHA Maine Affiliate 59. March 15, 1994 “Ongoing Clinical Trials with Antiarrhythmic Drugs and Defibrillators.” Atlanta, GA Symposium on Prevention of Sudden Death, American College of Cardiology 60. May 10, 1994 “The Relationship Between Non-sustained Ventricular Tachycardia and Lexington, KY Sudden Death.” Cardiology Grand Rounds University of Kentucky 61. September 21-24, 1994 “Interpretation of Intracardiac Tracings in Patients with Bypass Tracts.”
Philadelphia, PA Clinical Electrophysiology: Cardiovascular Board Review, presented by The American College of Cardiology 62. September 21-24, 1994 “Atypical Ventricular Tachycardias.” Philadelphia, PA Clinical Electrophysiology: Cardiovascular Board Review, presented by
The American College of Cardiology 63. September 26-29, 1994 “Nonsustained Ventricular Tachycardia: Significance, Mechanisms, Boston, MA Management.” Clinical Electrophysiology Board Review, presented by Harvard Medical
School 64. September 26-29, 1994 “Ventricular Tachycardias Associated with Nonischemic Heart Disease.” Boston, MA Clinical Electrophysiology Board Review, presented by Harvard medical School 65. October 5, 1994 “Primary Prevention of Sudden Cardiac Death.” Detroit, MI Symposium on Current Cardiac Therapy, Oakwood Hospital 66 November 15, 1994 “Nonsustained Ventricular Tachycardia in Ischemic Heart Disease.” Dallas, TX Plenary Session VII American Heart Association 67th Scientific Sessions 67. March 22, 1995 "Primary Prevention of Sudden Death in Patients with Ischemic Heart Dallas, TX Disease." Medical Grand Rounds, Presbyterian Medical Center 68. May 6, 1995 "The Multicenter UnSustained Tachycardia Trial." Boston, MA North American Society of Pacing and Electrophysiology, Core Curriculum - The Major Multicenter Trials 69. June 16, 1995 "Approach to Management of the Patient with Non-sustained Ventricular
21
Albany, NY Tachycardia." Cardiology Grand Rounds, Albany Medical College 70. November 8, 1995 "The Primary Prevention of Sudden Death in Patients with Coronary Nashville, TN Artery Disease." Cardiology Grand Rounds , Vanderbilt University 71. January 16, 1996 "Mechanisms of Sudden Death in Patients with Coronary Artery Ann Arbor, MI Disease." Cardiology Grand Rounds, University of Michigan 72. March 20, 1996 "Sudden Death in Patients with Coronary Artery Disease – Ongoing Louisville, KY Trials." Cardiology Grand Rounds, University of Louisville 73. April 20, 1996 "Sudden Cardiac Death: Past, Present and Future", - "Prospective Washington, DC Identification of the Problem." Basic Science and Nursing Symposium AHA, Council on Clinical Cardiology 74. May 15, 1996 "The MUSTT Trial: Rationale and Status." Seattle, WA Mini-Course, "Prevention of Cardiac Arrest in High Risk Individuals” North American Society of Pacing and Electrophysiology 75. May 17, 1996 "Who Needs Electrophysiologic Testing for Ventricular Tachycardia- Seattle, WA Ventricular Fibrillation?" Meet the Experts Luncheon, North American Society of Pacing and Electrophysiology 76. October 11, 1996 "Arrhythmias Complicating Acute Myocardial Infarction." Santa Fe, NM Colloquium on Cardiovascular Therapy, American College of Cardiology 77. October 24, 1996 "Prevention of Sudden Death after Myocardial Infarction." Houston, TX Cardiology Grand Rounds, University of Texas - Houston 78. November 9, 1996 "Nonsustained Ventricular Tachycardia in Coronary Artery Disease - To New Orleans, LA Treat or Not to Treat." Cardiology Symposium, Tulane University 79. November 21, 1996 "Mechanisms and Therapy of Atrial Arrhythmias" Chicago, IL Cardiology Rounds, Cook County Hospital 80. November 21, 1996 "Treatment of Supraventricular Arrhythmias - Drugs versus Ablation." Chicago, IL Cardiology Grand Rounds, Rush-Presbyterian Medical Center 81. April 14, 1997 "The Primary Prevention of Sudden Cardiac Death-Impact of Recent Boston, MA Trials." Cardiology Grand Rounds, Beth Israel Hospital, 82. September 18, 1997 "Current Treatment of Atrial Fibrillation." Binghamton, NY Krembs Cardiac Teaching Day, United Health Services Hospitals 83. October 17, 1997 "Acute & Chronic Therapy of Atrial Fibrillation." Chicago, IL Cardiology Rounds, Cook County Hospital 84. October 17, 1997 "The Primary Prevention of Sudden Death in Ischemic Heart Disease." Chicago, IL Cardiology Grand Rounds, Northwestern University Medical Center 85. November 10, 1997 "Drug Therapy and ICD Placement for Ventricular Arrhythmias – Orlando, FL Randomized Trials." Cardiovascular Seminar, AHA Council on Clinical Cardiology 86. March 18, 1998 "Mechanisms of Sudden Cardiac Death" Louisville, KY Cardiology Grand Rounds, University of Louisville 87. May 6, 1998 "Risk Stratification for Sudden Cardiac Death, Noninvasive vs. Invasive – San Diego, CA Electrophysiologic Studies." MiniCourse, North American Society of Pacing and Electrophysiology 88. May 7, 1998 "Recent Clinical Trials – MUSTT."
22
San Diego, CA Core Curriculum, North American Society of Pacing and Electrophysiology
89. December 3,1998 “Electrophysiologic Characterization of Patients with Ventricular Baltimore, MD Arrhythmias Complicating Coronary Artery Disease.” Cardiology Grand Rounds, University of Maryland 90. March 8, 1999 “The Multicenter UnSustained Tachycardia Trial” (“Late breaking clinical New Orleans, LA trials”). Annual Scientific Meeting, American College of Cardiology 91. May 12, 1999 “Clinical Trials – Results of the MUSTT Trial.” Toronto, Ontario Mini-Course, North American Society of Pacing and Electrophysiology 92. May 13, 1999 “An Update on the Recent Clinical Trials – New Results of the MUSTT Toronto, Ontario Trial” Core Curriculum, North American Society of Pacing and
Electrophysiology 93. May 15, 1999 “Primary Prevention Trials in Patients with Congestive Heart Failure.” Toronto, Ontario Core Curriculum, North American Society of Pacing and
Electrophysiology 94. November 16, 1999 “Electrophysiologic and Clinical Characteristics of Patients with Coronary Chicago, IL Artery Disease and Ventricular Tachyarrhythmias.” Cardiology Conference, Northwestern University 95. November 16,1999 “The Multicenter Unsustained Tachycardia Trial.” Chicago, IL Chicago Electrophysiological Society Annual Meeting 96. March 1, 2000 “What has the MUSTT Taught Us?” Portland, OR Cardiac Visiting Professor, Legacy Heart Institute 97. April 5, 2000 “New Findings from the MUSTT Study” Miami, FL Cardiology Grand Rounds, University of Miami 98. April 26, 2000 “Prevention of Sudden Death in Patients with Coronary Disease.” Cleveland, OH Visiting Professor - Heart Center Grand Rounds, Cleveland Clinic 99. April 15, 2000 “Antiarrhythmic Therapy: Drugs, Devices, and Ablation.” Philadelphia, PA Annual Session Workshop, American College of Physicians 100. May 18, 2000 “MUSTT Substudies.” Washington, DC Core Curriculum, North American Society of Pacing and
Electrophysiology 101. May 19, 2000 “Risk Stratification for Sudden Death.” Washington, DC Featured Symposium, North American Society of Pacing and Electrophys. 102. September 13, 2000 “ICD Clinical Trials and their Relevance in Heart Failure” Boca Raton, FL 4th Annual Scientific Meeting, Heart Failure Society of America 103. October 14, 2000 “Identification of Patients at Risk for Sudden Death” Traverse City, MI Michigan Chapter Annual Meeting, American College of Cardiology 104. November 13, 2000 "Who Needs an ICD the Week After MI?” New Orleans, LA 73rd Scientific Sessions, Plenary Session II, American Heart Association 105. November 20, 2000 “How to Prevent Sudden Death After MI – Results of Recent Trials.” Hershey, PA Cardiology Grand Rounds, Penn State College of Medicine 106. December 6, 2000 “Utility of the Signal-Averaged ECG to Predict Sudden Death – Results New York, NY of the MUSTT Trial.” Cardiology Grand Rounds, St. Luke’s-Roosevelt Hospital Center 107. January 11, 2001 “Primary and Secondary Prevention of Sudden Cardiac Death.”
23
Norfolk, VA Conference on Sudden Cardiac Death Prevention and Treatment Eastern Virginia Medical School 108. April 11, 2001 “Risk Stratification and Prevention of Sudden Death After MI” San Diego, CA Cardiology Grand Rounds, University of California at San Diego 109. May 2, 2001 “Risk Stratification in Patients with Ischemic Heart Disease: Should we Boston, MA Resuscitate the Signal-Averaged ECG?” Mini-Course - Advances in Non-Invasive Risk Stratification North American Society of Pacing and Electrophysiology, 110. May 10, 2001 “Identification of Patients with Coronary Artery Disease at Risk for Cleveland, OH Sudden Death.” Cardiology Grand Rounds, Case Western Reserve University 111. May 24, 2001 “Prevention of Sudden Death in Patients with Ischemic Heart Disease.” Philadelphia, PA Cardiology Grand Rounds, University of Pennsylvania 112 Sept.11, 2001 “Prevention of Sudden Death in Patients with Heart Failure- Evidence Washington, DC from Recent Clinical Trials.” 5th Annual Scientific Meeting Heart Failure Society of America 113. May 9, 2002 “The MUSTT Study – Recent Substudies.” San Diego, CA Core Curriculum – Update on Clinical Trials North American Society of Pacing and Electrophysiology, Annual Meeting 114. May 10, 2002 “Lessons from Primary Prevention Trials in Patients with Coronary Artery San Diego, CA Disease”
Featured Symposium – Impact of Device Therapy on the Management of Patients with Ventricular Arrhythmias
North American Society of Pacing and Electrophysiology, Annual Meeting 115. July 15, 2002 “Prevention of Sudden Death in Patients with Coronary Artery Disease”
Indianapolis, IN Cardiology Grand Rounds, Indiana University School of Medicine 116. December 11, 2002 “Prevention of Sudden Death in Patients with Coronary Artery Disease” Minneapolis, MN Cardiology Grand Rounds, University of Minnesota 117. January 8, 2003 “Prevention of Sudden death in Patients with Ischemic Heart Disease.” Philadelphia, PA Medical Grand Rounds, Temple University School of Medicine 118. April 8, 2003 “Prevention of Sudden death in Patients with Ischemic Heart Disease.” Chicago, IL Cardiology Research Conference, Northwestern University School of Medicine 119. April 12, 2003 “Primary Prevention of Sudden Death.” New York, NY Update on Cardiac Arrhythmias, Cornell Medical School 120. May 15, 2003 ”Risk stratification in coronary disease: All you need is EF – Antagonist.” Washington, DC Controversies Electrophysiology, North American Society of Pacing and Electrophysiology, 24th Annual Meeting 121. May 16, 2003 ”Noninvasive risk stratification in coronary disease – data from the Washington, DC MUSTT study.” Core Curriculum-North American Society of Pacing and Electrophysiology 122. November 9, 2003 “Prevention of Sudden Cardiac Death – Role of Devices.” Orlando, FL Cardiovascular Seminar – Electrophysiology of Sudden Cardiac Death American Heart Association 76th Annual Scientific Sessions 123. March 8, 2004 “New Implantable Cardioverter Defibrillator Indications” New Orleans, LA Chair, Panel - American College of Cardiology Annual Scientific Session 124. May 1, 2004 “Advances in Management of Heart Failure – Interventional Treatment of
24
Philadelphia, PA Heart Failure – ICDs and Pacemakers” Medcine Grand Rounds, Temple University School of Medicine 125. May 12, 2004 “Prevention of Sudden Death – How Should Recent Trials Affect New Orleans, LA management?” Medicine Grand Rounds, Tulane University School of Medicine 126. May 12, 2004 “Prevention of Sudden Death in Patients with Coronary Disease – A New New Orleans, LA Paradigm” Cardiology Grand Rounds, Tulane University School of Medicine 127. May 21, 2004 “Sudden Cardiac Death – An Evolving Paradigm” San Francisco, CA Chair, Featured Symposium - Heart Rhythm Society Annual Meeting 128. May 21, 2004 “Risk Stratification for VT by Noninvasive Methods is Possible – San Francisco, CA Antagonist” Featured Debate, Heart Rhythm Society Annual Meeting 129. September 27, 2004 “Does Everyone with Heart Disease Need an ICD? Can We Identify the Philadelphia, PA Low Risk Patient?” Leonard Horowitz Memorial Lecture, University of Pennsylvania School
of Medicine 130. October 20, 2004 “Prevention of Sudden Death – Who Benefits from the ICD?” Nashville, TN Cardiology Grand Rounds, Vanderbilt University 131. October 22, 2004 “The Current State of Clinical Trials for Prevention of Sudden Death. Seattle, WA Where are we now? Where Do we Go?” Keynote Address - DAVID II Trial Steering Committee Meeting 132. November 8, 2004 “Controversies in Clinical Cardiology: Everyone with an Ejection Fraction New Orleans, LA of <0.40 Should Receive an AICD: Con” Annual Scientific Sessions, American Heart Association 133. February 9, 2005 “Identifying Patients with Coronary Disease Who Need an ICD” Camden, NJ Cardiology Grand Rounds, UMDNJ, Cooper Hospital 134. March 6, 2005 “Patients with Idiopathic Dilated Cardiomyopathy Should Now Undergo Orlando, FL Implanted Cardioverter Defibrillator Implantation When the Ejection Fraction Is Less Thank 35%-- Antagonist.”
Great Debates in Electrophysiology, American College of Cardiology Annual Scientific Session 135. May 6, 2005 “Electrophysiologic Testing Should be Performed in All Coronary New Orleans, LA Disease Patients with EF 30-40% - Protagonist.” Featured Debate Heart Rhythm Society Annual Meeting 136. November 16, 2005 “Primary Prevention of Sudden Death in Ischemic Heart Disease.” Dallas, TX Plenary Session, American Heart Association Annual Scientific Sessions 137. March 11, 2006 “Interventions Such as ICDs Should be Used in the Elderly” (Pro) Atlanta, GA Debate - Society of Geriatric Cardiology, 12th Annual Scientific Session 138. March 12, 2006 “Great Debates in Electrophysiology” Atlanta, GA Co-Chair, American College of Cardiology, Annual Scientific Session 139. March 12, 2006 “Analysis of Complex Arrhythmias.” Atlanta, GA Panelist, American College of Cardiology, Annual Scientific Session 140. April 21, 2006 “Prevention of Sudden Death – Does Everyone Need an ICD?” Albuquerque, NM Cardiology Grand Rounds, University of New Mexico 141. April 26, 2006 “Identification of Patients with CAD at Risk of Sudden Death.”
25
San Diego, CA Cardiology Grand Rounds, University of California at San Diego 142. May 18, 2006 “How Can Physicians Use the ICD Registry?” Boston, MA Clinical Tutorial - Heart Rhythm Society Annual Scientific Sessions 143. May 19, 2006 “CMS Guidelines for ICD Implant Reflect Good Clinical Practice – Boston, MA Protagonist” Debate - Heart Rhythm Society Annual Scientific Sessions 144. October 26, 2006 “The New Guidelines on Prevention of Sudden Death. Do They Help or Philadelphia, PA Hinder?” Cardiology Grand Rounds, University of Pennsylvania 145. April 11, 2007 “Prediction of Sudden Cardiac Death – Limited Role of Ejection Fraction” Cleveland, OH Cardiology Grand Rounds, Case Western Reserve University Metrohealth Medical Center 146. May 11, 2007 “Electrophysiology Evaluation of VT” Denver, CO Expert Commentator, Abstract Session - Heart Rhythm Society Annual Scientific Sessions 147. October 27, 2007 “Debate – Prophylactic VT Ablation – Too Early for Standard of Care.”
Philadelphia, PA Second International Symposium on Ventricular Arrhythmias: 148. November 5, 2007 “Identifying the High Risk Post-MI Patient” Orlando, FL Cardiovascular Seminar - American Heart Association Annual Scientific Sessions 149. April 10, 2008 “Risk stratification for sudden death in coronary disease. Cleveland, OH Cardiology Grand Rounds, Case Western Reserve University 150. May 16, 2008 “Potential Adverse Effects of Inappropriate Shocks on the Heart” San Francisco, CA Core Curriculum - Heart Rhythm Society Annual Scientific Sessions 151. May 17, 2008 “Who Needs an ICD – Coronary Artery Disease.” San Francisco, CA Featured Symposium Heart Rhythm Society Annual Scientific Sessions 152. September 12, 2008 “Overview of Mechanisms of Cardiac Arrhythmias.” Boston, MA Advanced Track, American Society of Nuclear Cardiology Annual
Scientific Session 153. September 22, 2008 “Ventricular Arrhythmia Risk Stratifiers – State of the Art 2008.” Toronto, Ontario Heart Failure Society of America, Annual Scientific Session 154. October 24, 2008 “Debate – Indication for Prophylactic ICD Early After MI – Current are Miami,FL Appropriate.” Third International Symposium Ventricular Arrhythmias 155. March 31, 2009 “Clinical Electrophysiology-Supraventricular Arrhythmias.” Orlando, FL Poster Discussant - American College of Cardiology, 58th Annual Scientific Session 156. March 31, 2009 “Controversies in the Treatment of Ventricular Tachycardia.” Orlando, FL Meet the Experts Panelist - American College of Cardiology, 58th Annual Scientific Session 157. May 14, 2009 “Non-invasive risk stratification for SCD in Structural Heart Disease.” Boston, MA Ideas on Trial Debate - Heart Rhythm Society Annual Scientific
Sessions 158. May 14, 2009 “New Insights for treatment of ventricular arrhythmias.” Boston, MA Abstract Session Commentator - Heart Rhythm Society Annual Scientific Sessions 159. May 16, 2009 “ICD Implantation for EF >30%.”
26
Boston, MA Heart Rhythm Society Annual Scientific Sessions 160. October 9, 2009 “Clinical and Electrical Markers for Sudden Death Risk Assessment.” Philadelphia, PA Fourth International Symposium on Ventricular Arrhythmias 161. January 20, 2010 “Prediction of Sudden Death Risk.” New York, NY Cardiology Grand Rounds, St. Lukes-Roosevelt Hospital 162. May 12, 2010 “VT: From Basic Physiology to Clinical Management.” Denver, CO Senior Chair, VT/VF/Heart Failure Summit - Heart Rhythm Society
Annual Scientific Sessions 163. May 13, 2010 “Risk Assessment Using Programmed Ventricular Stimulation.” Denver, CO Core Curriculum - Heart Rhythm Society Annual Scientific Sessions 164. May 13, 2010 “Controversies in Indications and Timing of ICD Implantation.” Denver, CO Commentator, Abstract Session Heart Rhythm Society Annual Scientific Sessions 165. May 13, 2010 “Controversies in ICD/CRT Implantation: What to do When the Denver, CO Guidelines Don’t Apply.” Quality Commentator, Core Curriculum Heart Rhythm Society Annual Scientific Sessions 166. May 14, 2010 “QRS Duration >130msec is Sufficient Criteria for CRT Therapy- Denver, CO Antagonist.” Debate - Heart Rhythm Society Annual Scientific Sessions 167. May 14, 2010 “Under-Referral for Primary Prevention ICDs: Who, Where, and Why?” Denver, CO Senior Chair, Core Curriculum Heart Rhythm Society Annual Scientific Sessions 168. September 13, 2010 “Epidemiology and risk stratification for sudden cardiac death.” San Diego, CA Heart Failure Society of America, Annual Scientific Session 169. October 8, 2010 “What is the Future of Sudden Death Risk Stratification-Imaging, EP NYC, NY Testing, Multifactorial Schemes?” Fifth Annual International Symposium on Ventricular Arrhythmias 170. November 4, 2010 “Risk Stratification for Sudden Death – Role of Imaging and other Milwaukee, WI Techniques.” Cardiology Grand Rounds, Medical College of Wisconsin 171.January 18, 2011 “Risk Stratification for Sudden Death: Where Have we Been? Where are Indianapolis, IN we Going?” Visiting Professor, Indiana University School of Medicine 172. April 3, 2011 “Uncommon ICD Implant Considerations.” Expert Panel New Orleans, LA Panelist, American College of Cardiology, Annual Scientific Session 173. April 5, 2011 “Stroke Prevention in Atrial Fibrillation.” Expert Panel New Orleans, LA Panelist, American College of Cardiology, Annual Scientific Session 174. May 5, 2011 “Risk Stratification for SCD-Are MADIT-II and SCD-HeFT Enough?” San Francisco, CA Debate, Heart Rhythm Society Annual Scientific Sessions 175. May 6, 2011 “EP Testing–Risk Stratification for SCD in Patients with Ischemic San Francisco, CA Cardiomyopathy” Core Curriculum Lecture, Heart Rhythm Society Annual Scientific
Sessions 176. Sept 19, 2011 “Arrhythmias in Heart Failure: Low Ejection Fraction vs. Preserved
Boston, MA Ejection Fraction” Heart Failure Society of America Annual Scientific Meeting
27
177. March 26, 2012 “ICDs Should be Used More Judiciously in the Primary Prevention Chicago, IL Population”
Joint Session of the Japanese College of Cardiology and the American College of Cardiology
American College of Cardiology 61st Annual Scientific Session 178. March 26, 2012 Co-Chair ACC Symposium “Challenges in the Management of Ventricular
Chicago, IL Arrhythmias” American College of Cardiology 61st Annual Scientific Session 179. May 09, 2012 “Relevance of Multicenter Adult Trials to Pediatric and Congenital Patients.” Boston, MA Heart Rhythm Society Annual Scientific Sessions - Minicourse 180. May 09, 2012 “Is There a Role For EP Testing In Identifying Patients Who Benefit From
ICD Implantation?” Boston, MA Heart Rhythm Society Annual Scientific Sessions - Minicourse 181. May 10, 2012 Factors Associated With Mortality Following ICD Implantation - Abstract
Commentator Boston, MA Heart Rhythm Society Annual Scientific Sessions 182. May 11, 2012 “EP Testing for Risk Stratification: Is There a Role?” Boston, MA Heart Rhythm Society Annual Scientific Sessions - Minicourse 183. May 11, 2012 “Is sudden death always caused by VT/VF?” – Abstract Commentator Boston, MA Heart Rhythm Society Annual Scientific Sessions 184. October 22, 2012 “Risk Stratification for Sudden Death” Cleveland, OH Electrophysiology Teaching Conference Cleveland Clinic 185. May 8, 2013 MiniCourse Invited Speaker – “Should Patients With Primary Prevention
ICDs and Improved LV Function Undergo Generator Replacement?” Denver, CO Heart Rhythm Society Annual Scientific Sessions 186. May 9, 2013 Chair - Debate: “At ERI, Primary Prevention CRT-ICDs Should Be
Replaced With CRT-Pacemakers if LVEF >35%” Denver, CO Heart Rhythm Society Annual Scientific Sessions 187. May 9, 2013 Abstract Session Commentator, “Contemporary Complications of Cardiac
Implantable Electronic Devices” Denver, CO Heart Rhythm Society Annual Scientific Sessions 188. October 18, 2013 Chair, Panel Discussion “Why is ICD Use Declining?” Philadelphia, PA 8th International Symposium on Ventricular Arrhythmias/ Univ of Penna. 189. November 22, 2013 “The Conventional ICD is Here to Stay” – Debate Beverly Hills, CA Controversies and Advances in Cardiovascular Disease Symposium,
Cedars-Sinai Medical Center 190. November 4, 2014 “Sudden Cardiac Death – Personalization of Risk” Indianapolis, IN Indiana University School of Medicine, Cardiology Grand Rounds 191. December 3, 2014 Roy W. Scott Distinguished Visiting Professor – Cleveland, OH Case-Western Reserve University - Metro Health 192. April 16-17, 2015 “Potential opportunities linking CV imaging to clinical action” Washington, DC Cardiovascular Molecular Imaging Think Tank: Devising Strategies to
Bridge the Translational Divide 193. May 5, 2015 “Improving Use of ICDs to Prevent Sudden Death” New York, NY Lenox Hill Hospital, Visiting Professor, Cardiology Grand Rounds
28
194. May 15, 2015 “Mark Josephson: The Man - in a Special Session entitled History Session: Mark E. Josephson, MD - Arrhythmia Investigator, Pioneer, Innovator, Mentor”
Boston, MA Heart Rhythm Society Annual Scientific Sessions 195. May 15, 2015 “Chair in a Special Session entitled HeartRhythm Journal Presents: New
Advances in the Management of Heart Failure” Boston, MA Heart Rhythm Society Annual Scientific Sessions 196. May 16, 2015 Invited Speaker—“EKG Tracings, in a Mini Board Review entitled Mini
Board Review for Fellows” Boston, MA Heart Rhythm Society Annual Scientific Sessions 197. June 29, 2015 Invited Speaker—“Progress in the MEUSE-D Study” Washington, DC Path to Improved Risk Stratification – Working Group/Think Tank 198. October 10, 2015 Invited Speaker – “Do We Implant Too Many ICDs?” Philadelphia, PA 10th International Symposium on Ventricular Arrhythmias 199. November 8, 2015 “New directions in risk stratification of sudden cardiac death: present
challenges and future solutions” Orlando, FL American Heart Association Annual Scientific Sessions 200. November 10, 2015 Debate – “Ablation as First-Line Therapy for VT” (Con) Orlando, FL American Heart Association Annual Scientific Sessions 201. December 4, 2015 Role of ICDs in End Stage Renal Failure Washington, DC Cardiovascular Clinical Trialists Annual Scientific Forum 202. April 2016 “Current Status of Risk Stratification for Sudden Death – North American
Perspective” – Annual Scientific Meeting of the International Society for Computerized Electrocardiography
203. June 15, 2016 Invited Speaker—“Progress in Risk Stratification for Sudden Cardiac Death”
Washington, DC Path to Improved Risk Stratification – Working Group/Think Tank 204. May 11, 2017 Mark E. Josephson, MD – A Perspective Chicago, IL Annual Scientific Meeting of the Cardiac Electrophysiology Society 205. May 13, 2017 “Role of Cardiac Implantable Device Therapy in Special Patient
Populations: A Case-Based Approach – History Commentator” Chicago, IL Heart Rhythm Society Annual Scientific Sessions 206. June 6, 2017 Invited Speaker—“The Protect-ICD Study” Washington, DC Path to Improved Risk Stratification – Working Group/Think Tank 207. November 1, 2017 “Novel Methods to Stratify Sudden Death Risk” Minneapolis,MN Univ. of Minnesota Visiting Professor, Cardiology Grand Rounds Speaker 208. February 5, 2018 Sudden Death Risk Stratification St. Louis, MO Washington University, Visiting Professor, Cardiology Electrophysiology
Research Group Spkr International Invited Presentations 1. June 3-4, 1982 "Electrical stimulation to predict and assess antiarrhythmic efficacy"
Ghent,Belgium Symposium on Chronic Antiarrhythmic Therapy 2. August 31, 1983 “Role of Programmed Stimulation for Evaluation of Ventricular Altenberg, Germany Tachycardia” International workshop on New progress in the identification of patients at
29
risk of ventricular tachyarrhythmias 3. May 5-8, 1985 "Surgical therapy of ventricular tachycardia."
Cologne, Germany International symposium on invasive cardiovascular therapy--recent advances and future developments
4. September 23-26, 1986 "Arrhythmogenic effects of antiarrhythmic drugs: Role of Munich, Germany electrophysiologic studies." Symposium on Cardiac Arrhythmias 5. May 4, 1989 "Electrophysiologic Core Curriculum: Symposium - Evaluation and Toronto, Canada management of patients with Ventricular Tachyarrhythmias."
Annual Scientific Sessions, North American Society of Pacing and Electrophysiology
6. October 3, 1990 "Ventricular arrhythmias -- How should we treat them?" Ottawa, Canada Post Graduate Cardiology Rounds, Ottawa Heart Institute 7. October 4, 1990 "Sudden cardiac death." Ottawa, Canada Medical Grand Rounds, Ottawa Heart Institute 8. October 4, 1990 "Treatment of nonsustained ventricular tachycardia." Montreal, Canada Medical Grand Rounds, Hopital du Sacre-Cœur 9. October 5, 1990 "Treatment of nonsustained ventricular tachycardia." Montreal, Canada Medical Grand Rounds, Hotel-Dieu de Montreal 10. October 5, 1990 "Ventricular tachycardia and surgical approach for ventricular
tachycardia." Montreal, Canada Medical Grand Rounds, Royal Victoria Hospital 11. March 25-27, 1993 "Current Status and Preliminary Results of the MUST Trial." Vienna, Austria European Society of Cardiology - Update in Sudden Cardiac Death 12. June 20, 1998 "The Multicenter Unsustained Tachycardia Trial." Nice, France Cardiostim, Eleventh World Congress of Electrophysiology 13. July 10, 1998 ”The Multicenter Unsustained Tachycardia Trial" Madrid, Spain Madrid Interventional Cardiology Course 14. April 15, 1999 “The MUSTT Trial.” Madrid, Spain Tenth Madrid Arrhythmia Course 15. February 17, 2000 “Results of the MUSTT Trial” Montreal, Canada Cardiology Grand Rounds, Montreal Heart Institute 16. April 16, 2000 “The Role of ICD Therapy in the Primary Prevention of VT/VF” Maastricht, Netherlands Congress - 2000: Future of Arrhythmology 17. June 14, 2000 “The Multicenter Unsustained Tachycardia Trial and Its Implications.” Nice, France Cardiostim 2000 - 12th International Congress 18. June 15, 2000 “Risk Stratification for Sudden Death: Is There a Role for Nice, France Electrophysiologic Study?” Cardiostim 2000 - 12th International Congress 19. June 16, 2000 “Has MADIT Made It? Can We Trust MUSTT?” Nice, France Cardiostim 2000 - 12th International Congress 20. June 16, 2000 “Nonsustained VT from Holter: Diagnostic Value Revisited by MADIT Nice, France and MUSTT.” Cardiostim 2000 - 12th International Congress 21. May 21, 2002 “Management of Ventricular Arrhythmias.” Montreal, Canada 11th International Congress on Cardiovascular Pharmacotherapy 22. June 14, 2006 “Which Patients with an EF <40% Should Have EPS?”
30
Nice, France Cardiostim - 15th International Congress 23. June 8, 2007 “Prediction and Prevention of Sudden Cardiac Death in Patients with Oulu, Finland Heart Failure/LV Dysfunction” XXI Nordic Congress of Cardiology 24. June 8, 2007 “Debate – Implantable Device Therapy is Indicated for the Majority of Oulu, Finland Patients with Heart Failure/LV Dysfunction – Con” XXI Nordic Congress of Cardiology 25. June 17, 2008 “Sudden Cardiac Death and Depressed EF – the Regulatory Agencies
Nice,France Point of View.” Cardiostim – 16th International Congress 26. March 5, 2010 “Current Status of Risk Stratification for Sudden Death.” Kyoto, Japan Plenary Speaker - Japanese Circulation Society, 74th Annual Scientific Meeting 27. June 16, 2010. “Approach to prevention of sudden death in patients with CAD and EF Nice, France >40%.” Cardiostim – 17th International Congress 28. June 16, 2010 "Current Recommendations for ICDs in Patient Groups not subjected to Nice, France Randomized Trials.” Co-Chair, Symposium, Cardiostim – 17th International Congress 29. June 16, 2010 “Inappropriate ICD Shocks: Can we Better Predict and Reduce the Nice, France Incidence?” Co-Chair, Abstract Session, Cardiostim – 17th International Congress 30. April 8, 2011 “The Appropriate Roles of ICD vs. Catheter Ablation for VT: Who Really Needs an ICD?” Guangzhou, China Guest Speaker, 13th South China International Congress of Cardiology 31. Dec 7, 2012 “Identification of Individuals at Risk for Sudden Cardiac Death” New Delhi, India 64th Annual Cardiological Society of India Conference, SAARC Cardiac
Congress 32. Dec 8, 2012 “Growing Indications for Dysrhythmia Management” New Delhi, India 64th Annual Cardiological Society of India Conference, SAARC Cardiac
Congress 33. Apr 24-26, 2013 “Role of Ventricular Function in Risk Stratification for Sudden Death” Maastricht, NL International Symposium on Risk Stratification for Sudden Death 34. October 23, 2014 “Possible steps in individualizing ICD benefit” Utrecht, NL EU-CERT-ICD Trial Investigator Meeting 35. December 4, 2015 “Use of ICDs in Patients with End-Stage Renal Disease” Washington, DC 12th Global Cardiovascular Clinical Trialists Forum 36. September 8, 2016 “Moving Risk Stratification Forward Following the DANISH Trial” Barcelona, SP EU-CERT-ICD Trial Investigator Meeting 37. March 31, 2017 “Sudden death in ischemic heart disease” Prague, CZ Sudden Cardiac Death International Symposium 38. September 8, 2017 “VT Ablation: What are we Missing-How Will We Get There?”
Boston, MA Second Annual Signals Summit – International Meeting on Electrogram Interpretation
31
32
Report of Clinical Activities and Innovations Current Licensure and Certification
Year Type of License or Certification
1999- Rhode Island, General Medical License
2011- Massachusetts, Medical License Practice Activities Type of activity Setting of practice Name and location of practice
• Since 1981 I have practiced clinical cardiac electrophysiology. This involves outpatient ambulatory office practice .5-1 day per week, inpatient attending and consultative practice for patients with cardiac arrhythmias, and performing invasive cardiac electrophysiology studies and catheter ablation. I conducted this practice at the Hospital of the University of Pennsylvania from 1981-1993, Temple University Hospital from 1993-1999, and at Rhode Island and Miriam Hospitals from 1999 to April 2011. On May 1, 2011 I moved my practice to Beth Israel Deaconess Medical Center, Boston.
Report of Education of Patients and Service to the Community
Activities 2000-2010 Lecturer and organizer Rhode Island and Miriam Hospitals I organized and lectured at an average of 2 community educational programs yearly.
2008 “Heart of Our Mission Award” AHA-RI Chapter 2003-2004,2009-2010, 2011-2012 “Best Doctors in America” 2010, 2011 “Who’s Who in America” 2012-2017 Boston Magazine “Top Doctor”
33
Report of Scholarship Publications ORIGINAL PUBLICATIONS IN PEER-REVIEWED JOURNALS RESEARCH PUBLICATIONS 1. Ryder RW, Wachsmuth IK, Buxton AE, Evans DG, DuPont HL, Mason E, Barret FF: Infantile
diarrhea produced by heat - stable enterotoxigenic Escherichia coli. N Engl J Med 295: 849-853, 1976.
Escherichia coli and necrotizing enterocolitis: lack of an association. J. Pediatr 91:302-303, 1977 3. Abrutyn E, Goodhart GL, Roos K, Anderson R, Buxton AE: Acinetobacter calcoaceticus outbreak
associated with peritoneal dialysis. Am J Epidem 107:328-335, 1978. 4. Buxton AE, Anderson RL, Werdegar D, Atlas E: Nosocomial respiratory tract infection and
colonization with Acinetobacter calcoaceticus. Epidemiologic characteristics. Am J Med 65:507-513, 1978.
5. Buxton AE, Anderson RL, Klimek J, Quintiliani R: Failure of disposable domes to prevent
multiply resistant Klebsiella pneumoniae: Epidemiology of an outbreak of apparent index case origin. Antimicrobial Agents and Chemotherapy 15:608-615, 1979.
7. Buxton AE, Highsmith AK, Garner JS, West CM, Stamm WE, Dixon RE, McGowan JE:
Contamination of intravenous infusion fluid: Effects of changing administration sets. Ann Int Med 90:764-768, 1979.
8. Buxton AE, Goldberg S, Hirshfeld JW, Wilson J, Mann T, Williams DO, Oliva P: Refractory
ergonovine induced coronary vasospasm: Importance of intracoronary nitroglycerin. Am J Cardiol 46:329-334, 1980.
9. Buxton AE, Josephson ME: Role of P wave duration as a predictor of post-operative atrial
ME, Kastor JA: Amiodarone for control of sustained ventricular tachyarrhythmias: Clinical and electrophysiologic effects in 51 patients. Am J Cardiol 50:1066-1074, 1982.
electrophysiologic effects and clinical efficacy in patients with sustained ventricular tachycardia or ventricular fibrillation. Am J Cardiol 51:759-765, 1983.
18. Roy D, Waxman HL, Buxton AE, Josephson ME: Horizontal and Longitudinal dissociation of the
A-V node during atrial tachycardia. PACE 6:569-576, 1983. 19. Waspe LE, Waxman HL, Buxton AE, Josephson ME: Mexiletine for control of drug-resistant
ventricular tachycardia: Clinical and electrophysiologic results in 44 patients. Am J Cardiol 51:1176-1181, 1983.
characteristics and long-term follow-up in 119 survivors of cardiac arrest: Relation to inducibility at electrophysiologic testing. Am J Cardiol 52:969-974, 1983.
Programmed ventricular stimulation at a second right ventricular site: An analysis of 100 patients, with special reference to sensitivity, specificity and characteristics of patients with induced ventricular tachycardia. Am J Cardiol 52:1184-1189, 1983.
28. Marchlinski FE, Buxton AE, Waxman HL, Josephson ME: Identifying patients at risk of sudden
death after myocardial infarction: Value of the response to programmed stimulation, degree of ventricular ectopic activity and severity of left ventricular dysfunction. Am J Cardiol 52:1190-1196, 1983.
factors in nonsustained ventricular tachycardia. Am J Cardiol 53:1275-1279, 1984. 33. Buxton AE, Waxman HL, Marchlinski FE, Untereker WJ, Waspe LE, Josephson ME: Role of
triple extrastimuli during electrophysiologic study of patients with documented sustained ventricular tachyarrhythmias. Circulation 69:532-540, 1984.
ventricular tachycardia in patients with idiopathic dilated cardiomyopathy: Electrophysiologic testing and lack of response to antiarrhythmic drug therapy. Circulation 70:451-456, 1984.
Endocardial mapping in humans in sinus rhythm with normal left ventricles: Activation patterns and characteristics of electrograms. Circulation 70:37-42, 1984.
ME: Limited role of intravenous propafenone hydrochloride in the treatment of sustained ventricular tachycardia: Electrophysiologic effects and results of programmed ventricular stimulation. J Am Coll Cardiol 4:378-381, 1984.
extrastimuli with and without atrial dysrhythmias. Am J Cardiol 54:755-761, 1984. 42. Buxton AE, Marchlinski FE, Doherty JU, Cassidy DM, Vassallo JA, Flores BT, Josephson ME:
Repetitive, monomorphic ventricular tachycardia: Clinical and electrophysiologic characteristics in patients with and patients without organic heart disease. Am J Cardiol 54:997-1002, 1984.
Josephson ME: Timing of the right ventricular apical electrogram during sustained ventricular tachycardia: Relation to surface QRS morphology and potential clinical implications. Am J Cardiol 54:1003-1007, 1984.
Comparative electrophysiologic effects of intravenous and oral procainamide in patients with sustained ventricular arrhythmias. J Am Coll Cardiol 4:1247-1254, 1984.
Limited role of intravenous propafenone hydrochloride in the treatment of sustained ventricular tachycardia: Electrophysiologic effects and results of programmed ventricular stimulation. J Am Coll Cardiol 4:378-81, 1984.
Kienzle MG, Almendral JM, Josephson ME: Electrophysiologic evaluation and follow-up characteristics of patients with recurrent unexplained syncope or presyncope. Am J Cardiol 55:703-708, 1985.
AH, Doherty JU, Grogan EW, Josephson ME: The automatic implantable cardioverter-defibrillator: Efficacy, complications, and device failures. Ann Int Med 104:481-488, 1986.
of endocardial activation pattern in patients with previous healed myocardial infarction and ventricular tachycardia. Am J Cardiol 58:479-484, 1986.
57. Poll DS, Marchlinski FE, Buxton AE, Josephson ME: Usefulness of programmed stimulation in idiopathic dilated cardiomyopathy. Am J Cardiol 58:992-997, 1986. 58. Almendral JM, Rosenthal ME, Stamato NJ, Marchlinski FE, Buxton AE, Frame LH, Miller JM,
Josephson ME: An analysis of the resetting phenomenon in sustained uniform ventricular tachycardia: incidence and the relation to termination. J Am Coll Cardiol 8:294-300, 1986.
59. Kadish AH, Marchlinski FE, Josephson ME, Buxton AE: Amiodarone: Correlation of early and
late electrophysiologic studies with outcome. Am Heart J 112:1134-1140, 1986.
38
60. Kienzle MG, Doherty JU, Cassidy DM, Buxton AE, Marchlinski FE, Waxman HL, Josephson ME: Electrophysiologic sequelae of chronic myocardial infarction: Local refractoriness and electrogram characteristics of the left ventricle. Am J Cardiol 58:63-69, 1986.
signal-averaged electrocardiography and electrophysiologic study in patients with nonsustained ventricular tachycardia after healing of acute myocardial infarction. Am J Cardiol 60:8085, 1987.
electrophysiologic study to determine the clinical tolerance of arrhythmia recurrences during amiodarone therapy. J Am Coll Cardiol 10:90-6, 1987.
67. Marchlinski FE, Buxton AE, Miller JM, Josephson ME: Prevention of ventricular tachycardia
induction during right ventricular programmed stimulation by high current strength pacing at the site of origin. Circulation 76:332-342, 1987.
68. Miller JM, Marchlinski FE, Buxton AE, Josephson ME: Relationship between the 12-lead
electrocardiogram during ventricular tachycardia and endocardial site of origin in patients with coronary artery disease. Circulation 77, 4:759-766, 1988.
69. Kleiman RB, Miller JM, Buxton AE, Josephson ME, Marchlinski FE: Prognosis following
sustained ventricular tachycardia occurring early after myocardial infarction. Am J Cardiol 62:528-533, 1988.
70. Marchlinski FE, Buxton AE, Kindwall KE, Miller JM, Rosenthal ME, Gottlieb CD, Bloom RB,
Josephson ME: Comparison of individual and combined effects of procainamide and amiodarone in patients with sustained ventricular tachyarrhythmias. Circulation 78, 3:583-591, 1988.
with induced onset of sustained ventricular tachycardia. Circulation 78, 4:885-892, 1988.
39
72. Vassallo JA, Marchlinski FE, Cassidy DM, Buxton AE, Josephson ME: Shortening of ventricular refractoriness with extrastimuli: Role of the degree of prematurity and number of extrastimuli. J Electrophysiol 2:227-236, 1988.
73. Buxton AE, Britton N, Simson MB: Application of the signal-averaged electrocardiogram in
patients with nonsustained ventricular tachycardia after myocardial infarction: Implications for prediction of sudden cardiac death risk. J Electrocardiology 21:S40-45, 1988.
74. Almendral JM, Gottlieb CD, Rosenthal ME, Stamato NJ, Buxton AE, Marchlinski FE, Miller JM,
Josephson ME: Entrainment of ventricular tachycardia: Explanation for surface electrocardiographic phenomena by analysis of electrograms recorded within the tachycardia circuit. Circulation 77:569-580,1988.
75. Schmitt CG, Kadish AH, Marchlinski FE, Miller JM, Buxton AE, Josephson ME: Effects of
lidocaine and procainamide on normal and abnormal intraventricular electrograms during sinus rhythm. Circulation 77:1030-1037, 1988.
electrophysiological testing and long-term follow-up in patients sustaining cardiac arrest only while receiving type IA antiarrhythmic agents. PACE 15:324-333,1991..
85. Hook BG, Marchlinski FE, Josephson ME, Buxton AE: Effect of high current stimulation in
patients with sustained ventricular tachycardia rendered noninducible by antiarrhythmic drugs. Am J Cardiol 70:752-757, 1992
induced by programmed stimulation: Response to Procainamide. J Am Coll Cardiol 21:90-8,1993. 87. Buxton, AE, Kleiman RB, Kindwall KE, Josephson ME: Endocardial Mapping During Sinus
Rhythm in Patients with Coronary Artery Disease and Nonsustained Ventricular Tachycardia. Am J Cardiol 71:695-698, 1993.
88. Vaitkus PT, Miller JM, Buxton AE, Josephson ME, Laskey WK: Ischemia-induced changes in
human endocardial electrograms during percutaneous transluminal coronary angioplasty. Am Heart J 127:1481-1490, 1994.
89. Hopson JR, Buxton AE, Rinkenberger RL, Nademanee K, Heilman JM, Kienzle MG, for the
Flecainide Supraventricular Tachycardia Study Group: Safety and Utility of flecainide acetate in the routine care of patients with supraventricular tachyarrhythmias: results of a multicenter trial. Am J Cardiol 77:72A-82A, 1996.
Prystowsky EN, Talajic M, for the Multicenter Unsustained Tachycardia Trial Investigators: Nonsustained ventricular tachycardia in patients with coronary artery disease: relationship to inducible sustained ventricular tachycardia. Ann Intern Med 125:35-39, 1996.
91. Sarter BH, Finkle JK, Gerszten RE, Buxton AE: What is the risk of sudden cardiac death in
patients presenting with hemodynamically stable sustained ventricular tachycardia after myocardial infarction? J Am Coll Cardiol 28:122-129, 1996.
92. Rothman SA, Jeevanandam V, Combs WG, Furukawa S, Hsia HH, Eisen HJ, Buxton AE, Miller
93. Cossu SF, Rothman SA, Chmielewski IL, Hsia HH, Vogel RL, Miller JM, Buxton AE: The effects
of isoproterenol on the cardiac conduction system: site-specific dose dependence. J Cardiovasc Electrophysiol 8:847-853, 1997.
94. Rothman SA, Hsia HH, Cossu SF, Chmielewski IL, Buxton AE, Miller JM: Radiofrequency
catheter ablation of postinfarction ventricular tachycardia. Long-term success and the significance of inducible nonclinical arrhythmias. Circulation 96:3499-3508, 1997.
41
95. Buxton AE, Hafley GE, Lehmann MH, Gold M, O'Toole M, Tang A, Coromilas J, Hook B,
Stamato NJ, Lee KL, for the Multicenter Unsustained Tachycardia Trial (MUSTT) Investigators. Prediction of sustained ventricular tachycardia inducible by programmed stimulation in patients with coronary artery disease: Utility of clinical variables. Circulation 1999;99:1843-1850.
96. Buxton AE, Lee KL, Fisher JD, Josephson ME, Prystowsky EN, Hafley GE, for the Multicenter
Unsustained Tachycardia Trial Investigators: A randomized study of the prevention of sudden death in patients with coronary artery disease. N Engl J Med 1999; 341:1882-90.
97. Buxton AE, Lee KL, DiCarlo L, Gold MR, Greer GS, Prystowsky EN, O’Toole MF, Tang A,
Fisher JD, Coromilas J, Talajic M, Hafley G, for the Multicenter Unsustained Tachycardia Trial Investigators: Electrophysiologic testing to Identify Patients with Coronary Artery Disease Who are at Risk for Sudden Death. N Engl J Med 2000;342:1937-45.
98. Singh SN, Karasik P, Hafley GE, Pieper KS, Lee KL, Wyse DG, Buxton AE, for the MUSTT
Investigators. Electrophysiologic and clinical effects of angiotensin-converting enzyme inhibitors in patients with prior myocardial infarction, nonsustained ventricular tachycardia, and depressed left ventricular function. Am J Cardiol 2001;87:716-720.
99. Gomes JA, Cain ME, Buxton AE, Josephson ME, Lee KL, Hafley GE. Prediction of long-term
outcomes by signal-averaged electrocardiography in patients with unsustained ventricular tachycardia, coronary artery disease, and left ventricular dysfunction. Circulation 2001; 104: 436-441.
100. Wyse DG, Talajic M, Hafley GE, Buxton AE, Mitchell LB, Kus TK, Packer DL, Kou WH,
Lemery R, Santucci P, Grimes D, Hickey K, Stevens C, Singh SN, for the MUSTT Investigators. Antiarrhythmic drug therapy in the Multicenter UnSustained Tachycardia Trial (MUSTT): drug testing and as-treated analysis. J Am Coll Cardiol 2001;38:344-351.
101. Pires LA, Lehmann MH, Buxton AE, Hafley GE, Lee KL, the Multicenter Unsustained
Tachycardia Trial Investigators. Differences in inducibility and prognosis of in-hospital versus out-of-hospital identified nonsustained ventricular tachycardia in patients with coronary artery disease: clinical and trial design implications. J Am Coll Cardiol 2001;38:1156-1162.
102. Lee KL; Hafley G; Fisher JD; Gold MR; Prystowsky EN, Talajic M, Josephson ME; Packer DL,
Buxton AE, for the Multicenter Unsustained Tachycardia Trial Investigators. Effect of Implantable Defibrillators on Arrhythmic Events and Mortality in the Multicenter Unsustained Tachycardia Trial. Circulation. 2002;106:233-238.
103. Pires LA, Hafley GE, Lee KL, Fisher JD, Josephson ME, Prystowsky EN, Buxton AE, for the
Multicenter Unsustained Tachycardia Trial Investigators. Significance of Nonsustained Ventricular Tachycardia Identified Postoperatively after Coronary Bypass Surgery in Patients with Left Ventricular Dysfunction. J Cardiovasc Electrophysiology. 2002;13:757-763.
Fisher JD, Prystowsky EN, Talajic MR, Pires LA, for the MUSTT Investigators. Relation of
42
Ejection Fraction and Inducible Ventricular Tachycardia to Mode of Death in Patients with Coronary Artery Disease. An Analysis of Patients Enrolled in the Multicenter Unsustained Tachycardia Trial. Circulation 2002;106:2466-2472.
105. Ellison KE, Hafley GE, Hickey K, Kellen J, Coromilas J, Stein KM, Lee KL, Buxton AE, for the
MUSTT Investigators. Effect of β-blocking Therapy on Outcome in the Multicenter UnSustained Tachycardia Trial (MUSTT). Circulation. 2002;106:2694-2699.
106. Russo AM, Hafley GE, Lee KL, Stamato NJ, Lehmann MH, Page RL, Kus T, Buxton AE. Racial
Differences in Outcome in the Multicenter UnSustained Tachycardia Trial (MUSTT): A Comparison of Whites Versus Blacks. Circulation 2003;108:67-72.
Reynolds M, Josephson ME. Electrocardiographic predictors of arrhythmic death and total mortality in the Multicenter Unsustained Tachycardia Trial. Circulation 2004;110:766-769.
108. Russo AM, Stamato NJ, Lehmann MH, Hafley GE, Lee KL, Pieper K, Buxton AE and the
MUSTT Investigators. Influence of gender on arrhythmia characteristics and outcome in the Multicenter Unsustained Tachycardia Trial. J Cardiovasc Electrophysiol 2004;15:993-998.
109. Buxton AE, Sweeney MO, Wathen MS, Josephson ME, Otterness MF, Hogan-Miller E, Stark AJ,
DeGroot PJ, for the PainFREE RXII Investigators. QRS Duration Does Not Predict Occurrence of Ventricular Tachyarrhythmias in Patients with Implanted Cardioverter-Defibrillators. J Amer Coll Card. 2005;46:310-316.
leads have increased sensing latency and threshold compared with the integrated bipolar configuration. J Cardiovasc Electrophysiol. 2007;18:192-196.
111. Ott P, Kirk MM, Koo C, He DS, Bhattacharya B, Buxton A. Coronary sinus and fossa ovalis
ablation: Effect on interatrial conduction and atrial fibrillation. J Cardiovasc Electrophysiol. 2007;18:310-317.
112. Fisher JD, Buxton AE, Lee KL, Packer DL, Echt DS, Denes P, Lehmann MH, DiMarco JP, Roy D,
Hafley GE; MUSTT Events Committee. Designation and distribution of events in the Multicenter UnSustained Tachycardia Trial (MUSTT). Am J Cardiol. 2007;100:76-83.
113. Stanchina ML, Ellison K, Malhotra A, Anderson M, Kirk M, Benser ME, Tosi C, Carlisle C,
Millman RP, Buxton A. The impact of cardiac resynchronization therapy on obstructive sleep apnea in heart failure patients: a pilot study. Chest. 2007;132:433-9.
Zimetbaum P. Sex differences in the relationship between amiodarone use and the need for permanent pacing in patients with atrial fibrillation. Arch Intern Med. 2007; 167:1648-1653.
sudden death risk in patients with coronary artery disease. Lessons from the MUSTT study. J Am Coll Cardiol 2007;50:1150-1157.
116. Roy D, Talajic M, Nattel S, Wyse DG, Dorian P, Lee KL, Bourassa MG, Arnold JMO, Buxton
AE, et al. Rhythm Control versus Rate Control for Atrial Fibrillation and Heart Failure. N Engl J Med 2008;358:2667-2677.
117. Bax JJ, Kraft O, Buxton AE, Fjeld JG, Parizek P, Agostini D, Knuuti J, Flotats A, Arrighi J, Muxi
A, Alibelli M-J, Banerjee G, Jacobson AF. 123I-mIBG Scintigraphy to predict inducibility of ventricular arrhythmias on cardiac electrophysiology testing. A prospective pilot study. Circ Cardiovasc Imaging. 2008;1:131-140.
118. Wilkoff BL, Kudenchuk PJ, Buxton AE, Sharma A, Cook JR, Bhandari AK, Biehl M, Tomassoni
G, Leonen A, Klevan LR, Hallstrom AP, for the DAVID II Investigators. The DAVID (Dual Chamber and VVI Implantable Defibrillator) II Trial. J Am Coll Cardiol 2009;53:872-880.
119. Piccini JP, Hafley GE, Lee KL, Fisher JD, Josephson ME, Prystowsky EN, Buxton AE, for the
MUSTT Investigators. Mode of Induction of Ventricular Tachycardia and Prognosis in Patients with Coronary Disease: The Multicenter UnSustained Tachycardia Trial (MUSTT). J Cardiovasc Electrophysiol; 2009;20:850-855.
120. Ziv O, Morales E, Song Y-K, Peng X, Odening K, Buxton AE, Karma A, Koren G, Choi BR.
Origin of Complex Behavior of Spatially Discordant Alternans in Transgenic Rabbit Model of LQT2. J Physiol. 2009;587:4661-4680.
Optimal Timing of Implantable Cardioverter-Defibrillator Implantation After Myocardial Infarction: A Decision Analysis. J Cardiovasc Electrophysiol 2010;21:791-798.
122. Al-Khatib SM, Hafley G, Lee KL, Buxton AE. Relation between time from myocardial infarction
to enrolment and patient outcomes in the Multicenter UnSustained Tachycardia Trial. Europace. 2010;12:1112-1118.
123. Mellion ML, Buxton AE, Iyer V, Almahameed S, Lorvidhaya P, Gilchrist JM. Safety of nerve
conduction studies in patients with peripheral intravenous lines. Muscle Nerve 42;2010:189-191. 124. AlMahameed ST, Buxton AE, Michaud GF. New criteria during right ventricular pacing to
determine the mechanism of supraventricular tachycardia. Circ Arrhythm Electrophysiol. 2010;3:578-584.
125. Wadehra V, Buxton AE, Antoniadis AP, McCready JW, Redpath CJ, Segal OR, Rowland E, Lowe MD, Lambiase PD, Chow AW. The use of a novel nitinol guidewire to facilitate transseptal puncture and left atrial catheterization for catheter ablation procedures. Europace. 2011;13:1401-5.
126. Miller AL, Wang Y, Curtis J, Masoudi FA, Buxton AE, Wang TY. Optimal Medical Therapy Use Among Patients Receiving Implantable Cardioverter/Defibrillators. Insights From the National Cardiovascular Data Registry. Arch Intern Med. 2012;172:64-67.
originating from the moderator band. J Cardiovasc Electrophysiol 2013;24:97-100. 129. Rayatzadeh H, Tan A, Chan RH, Patel SJ, Hauser TH, Ngo L, Shaw JL, Hong SN, Zimetbaum P,
Buxton AE, Josephson ME, Manning WJ, Nezafat R. Scar heterogeneity on cardiovascular magnetic resonance as a predictor of appropriate implantable cardioverter-defibrillator therapy. J Cardiovasc Magn Reson. 2013;15:31[Epub ahead of print]
130. Fein AS, Shvilkin A, Shah D, Haffajee CI, Das S, Kumar K, Kramer DB, Zimetbaum PJ, Buxton AE, Josephson ME, Anter E. Treatment of obstructive sleep apnea reduces the risk of atrial fibrillation recurrence following catheter ablation. J Am Coll Cardiol. 2013;62:300-305. PMID: 23623910
131. Kramer DB, Kennedy KF, Noseworthy PA, Buxton AE, Josephson ME, Normand S-L, Spertus JA, Zimetbaum PJ, Reynolds MR, Mitchell SL. Characteristics and Outcomes of Patients Receiving New and Replacement Implantable Cardioverter-Defibrillators: Results From the NCDR. Circ Cardiovasc Qual Outcomes. 111.000054published online before print June 11 2013, doi:10.1161/CIRCOUTCOMES.111.000054
132. Shen C, Jeong J, Li X, Chen P-S, Buxton A. Treatment benefit and treatment harm rate to
Siscovick DS, Alonso A, Buxton A, Folsom AR, Mukamal KJ. Height and risk of sudden cardiac death: the Atherosclerosis Risk in Communities and Cardiovascular Health Studies. Ann Epidemiol. 2013 Nov 26. PMID: 24360853.
Zimetbaum PJ, Mitchell SL, Reynolds MR. Mortality risk following replacement implantable cardioverter-defibrillator implantation at end of battery life: Results from the NCDR. Heart Rhythm. 2014;11:216-221.
135. Hoang A, Shen C, Zheng J, Taylor S, Groh WJ, Rosenman M, Buxton AE, Chen PS. Utilization
rates of implantable cardioverter-defibrillators for primary prevention of sudden cardiac death: A 2012 calculation for a Midwestern health referral region. Heart Rhythm. 2014;11:849-855. PMID: 24566233
136. Anter E, Tschabrunn CM, Contreras-Valdes FM, Buxton AE, Josephson ME. Radiofrequency
ablation annotation algorithm reduces the incidence of linear gaps and reconnection following pulmonary vein isolation: Ablation annotation algorithm to improve electrical contiguity during PVI. Heart Rhythm. 2014;11:783-790. PMID: 24583098.
45
137. Levine YC, Rosenberg MA, Mittleman M, Samuel M, Methachittiphan N, Link M, Josephson ME, Buxton AE. B-type natriuretic peptide is a major predictor of ventricular tachyarrhythmias. Heart Rhythm 2014;11:1109-1116. PMID: 24837348
138. Anter E, Silverstein J, Tschabrunn CM, Shvilkin A, Haffajee CI, Zimetbaum PJ, Buxton AE,
Josephson ME, Gelfand E, Manning WJ. Comparison of Intracardiac Echocardiography and Transesophageal Echocardiography for Imaging of the Right and Left Atrial Appendages. Heart Rhythm. 2014 Jul 14. pii: S1547-5271(14)00764-4. doi: 10.1016/j.hrthm.2014.07.015. [Epub ahead of print]. PMID: 25034183
139. Tschabrunn CM, Silverstein J, Berzin T, Ellis E, Buxton AE, Josephson ME, Anter E. Comparison
between single- and multi-sensor oesophageal temperature probes during atrial fibrillation ablation: thermodynamic characteristics. Europace. 2015 Jun;17(6):891-7. doi: 10.1093/europace/euu356. Epub 2015 Mar 15. PMID: 25777771
140. Waks JW, Higgins AY, Mittleman MA, Buxton AE. Influence of Renal Function on Mortality and
Ventricular Arrhythmias in Patients Undergoing First Implantable Cardioverter-Defibrillator Generator Replacement. J Cardiovasc Electrophysiol. 2015;26:282-290. PMID: 25431143
Calkins H, Morady F, Josephson ME. Coexistent Types of Atrioventricular Nodal Reentrant Tachycardia: Implications for the Tachycardia Circuit. Circ Arrhythm Electrophysiol. 2015 Jul 8. pii: CIRCEP.115.002971. [Epub ahead of print] PMID: 26155802
142. Contreras-Valdes FM, Buxton AE, Josephson ME, Anter E. Atrial fibrillation ablation in patients
with hypertrophic cardiomyopathy: long-term outcomes and clinical predictors. J Am Coll Cardiol. 2015 Apr 14;65(14):1485-7. doi: 10.1016/j.jacc.2014.12.063. PMID: 25857916
143. Levine YC, Tuttle MK, Rosenberg MA, Goldberg R, Matos J, Samuel M, Kramer DB, Buxton AE.
Prevalence and outcomes of patients receiving implantable cardioverter-defibrillators for primary prevention not based on guidelines. Am J Cardiol. 2015 Jun 1;115(11):1539-44. doi: 10.1016/j.amjcard.2015.02.056. Epub 2015 Mar 12. PMID: 25840578
144. Tschabrunn CM, Roujol S, Nezafat R, Faulkner-Jones B, Buxton AE, Josephson ME, Anter E. A
Swine Model of Infarct-Related Reentrant Ventricular Tachycardia: Electroanatomic, Magnetic Resonance, and Histopathologic Characterization. Heart Rhythm. 2015 Jul 27. PMID: 26226214
and risk factors for symptomatic heart failure after catheter ablation of atrial fibrillation and atrial flutter. Europace. 2015 Aug 26. pii: euv215. [Epub ahead of print] PMID: 26311563
146. Shvilkin A, Ellis ER, Gervino EV, Litvak AD, Buxton AE, Josephson ME. Painful left bundle
branch block syndrome: Clinical and electrocardiographic features and further directions for evaluation and treatment. Heart Rhythm. 2015 Aug 30. pii: S1547-5271(15)01015-2. doi: 10.1016/j.hrthm.2015.08.001. [Epub ahead of print]. PMID: 26331973
148. Serber ER, Fava JL, Christon LM, Buxton AE, Goldberger JJ, Gold MR, Rodrigue JR, Frisch MB. Positive Psychotherapy to Improve Autonomic Function and Mood in ICD Patients (PAM-ICD):
Rationale and Design of an RCT Currently Underway. Pacing Clin Electrophysiol. 2016 Jan 26. doi: 10.1111/pace 12820 [Epub ahead of print] PMID: 26813033
149. Madhavan M, Waks JW, Friedman PA, Kramer DB, Buxton AE, Noseworthy PA, Mehta RA, Hodge DO, Higgins AY, Webster TL, Witt CM, Cha YM, Gersh BJ. Outcomes after Implantable Cardioverter-Defibrillator Generator Replacement for Primary Prevention of Sudden Cardiac Death. Circ Arrhythm Electrophysiol. 2016 Mar;9(3):e003283. doi: 10.1161/CIRCEP.115.003283. PMID 26921377
150. Brooks GC, Lee BK, Rao R, Lin F, Morin DP, Zweibel SL, Buxton AE, Pletcher MJ, Vittinghoff E, Olgin JE; PREDICTS Investigators. Predicting Persistent Left Ventricular Dysfunction Following Myocardial Infarction: The PREDICTS Study. J Am Coll Cardiol. 2016;67:1186-96. PMID: 26965540
151. Waks JW, Sitlani CM, Soliman EZ, Kabir M, Ghafoori E, Biggs ML, Henrikson CA, Sotoodehnia N, Biering-Sørensen T, Agarwal SK, Siscovick DS, Post WS, Solomon SD, Buxton AE, Josephson ME, Tereshchenko LG. Global Electrical Heterogeneity Risk Score for Prediction of Sudden Cardiac Death in the General Population: The Atherosclerosis Risk in Communities (ARIC) and Cardiovascular Health (CHS) Studies. Circulation. 2016 pii: CIRCULATIONAHA.116.021306. [Epub ahead of print] PMID:27081116
152. Shen C, Hu Y, Li X, Wang Y, Chen PS, Buxton AE. Identification of subpopulations with distinct treatment benefit rate using the Bayesian tree. Biom J. 2016 Nov;58(6):1357-1375. PMID: 27356196
153. Anter E, Tschabrunn CM, Buxton AE, Josephson ME. High-Resolution Mapping of Postinfarction Reentrant Ventricular Tachycardia: Electrophysiological Characterization of the Circuit. Circulation. 2016 Jul 26;134(4):314-27. PMID:27440005
154. Katritsis DG, Marine JE, Contreras FM, Fujii A, Latchamsetty R, Siontis KC, Katritsis GD, Zografos TA, John RM, Epstein LM, Michaud GF, Anter E, Sepahpour A, Rowland E, Buxton AE, Calkins H, Morady F, Stevenson WG, Josephson ME. Catheter Ablation of Atypical Atrioventricular Nodal Reentrant Tachycardia. Circulation. 2016 134:1655-1663. PMID:27754882
155. Shen C, Hu Y, Li X, Wang Y, Chen PS, Buxton AE. Identification of subpopulations with distinct treatment benefit rate using the Bayesian tree. Biom J. 2016;58:1357-1375 PMID: 27356196
156. Adabag S, Patton KK, Buxton AE, Rector TS, Ensrud KE, Vakil K, Levy WC, Poole JE. Association of Implantable Cardioverter Defibrillators With Survival in Patients With and Without Improved Ejection Fraction: Secondary Analysis of the Sudden Cardiac Death in Heart Failure Trial. JAMA Cardiol. 2017; 2:767-774. PMID: 28724134
157. Anter E, Di Biase L, Contreras-Valdes FM, Gianni C, Mohanty S, Tschabrunn CM, Viles-Gonzalez JF, Leshem E, Buxton AE, Kulbak G, Halaby RN, Zimetbaum PJ, Waks JW, Thomas RJ, Natale A, Josephson ME. Atrial Substrate and Triggers of Paroxysmal Atrial Fibrillation in Patients With Obstructive Sleep Apnea. Circ Arrhythm Electrophysiol. 2017;10(11). pii: e005407. doi: 10.1161/CIRCEP.117.005407. PMID: 29133380
OTHER PEER-REVIEWED PUBLICATIONS 1. Buxton AE, Fisher JD, Josephson ME, Lee KL, Pryor DB, Prystowsky EN, Simson MB, DiCarlo
L, Echt DS, Packer D, Greer GS, Talajic M, et al: Prevention of Sudden Death in Patients with Coronary Artery Disease: The Multicenter Unsustained Tachycardia Trial (MUSTT). Prog Cardiovasc Dis 36: 215-226, 1993.
2. Al-Khatib SM, Sanders GD, Mark DB, Lee KL, Bardy GH, Bigger JT, Buxton AE, Connolly S,
Kadsh A, Moss A, Feldman AM, Ellenbogen KA, Singh S, Califf RM, Expert panel participating in a Duke Clinical Research Institute-sponsored conference. Implantable cardioverter defibrillators and cardiac resynchronization therapy in patients with left ventricular dysfunction: randomized trial evidence through 2004. Am Heart J. 2005;149:1020-34.
3. Sanders GD, Al-Khatib SM, Berliner E, Bigger JT, Buxton AE, Califf RM, Carlson M, Curtis AB,
Curtis JP, Domanski M, Fain E, Gersh BJ, Gold MR, Goldberger J, Haghighi-Mood A, Hammill SC, Harder JHealey J, Hlatky M, Hohnloser S, Kim RJ, Lee K, Mark D, Mianulli M, Mitchell B, Prystowsky EN, Smith J, Steinhaus D, Zareba W. Preventing tomorrow’s sudden cardiac death today: Part I: Current data on risk stratification for sudden cardiac death. Am Heart J 2007; 153:941-950.
4. Al-Khatib SM, Sanders GD, Bigger JT, Buxton AE, Califf RM, Carlson M, Curtis A, Curtis J, Fain E, Gersh BJ, Gold MR, Haghighi-Mood A, Hammill SC, Harder J, Healey J, Hlatky MA, Hohnloser SH, Lee KL, Mark DB, Mitchell B, Phurrough S, Prystowsky E, Smith JM, Stockbridge N, Temple R. Preventing tomorrow’s sudden cardiac death today: Part II: Translating sudden cardiac death risk assessment strategies into practice and policy. Am Heart J 2007; 153:951-959.
4. Pun PH, Al-Khatib SM, Edwards R, Bardy G, Bigger JT, Buxton A, Moss A, Lee K, Steinmann R,
Dorian P, Hallstrom A, Cappato R, Kadish A, Kudenchuk P, Mark D, Inoue LYT, Sanders GD. Influence of chronic kidney disease on the efficacy of primary prevention implantable cardioverter defibrillators: A meta-analysis of three randomized trials. J Am Coll Cardiol. 2013;61(10_S):. doi:10.1016/S0735-1097(13)60393-9
5. Hess PL, Laird A, Edwards R, Bardy GH, Bigger JT, Buxton AE, Moss AJ, Lee KL, Hall WJ,
Steinman R, Dorian P, Hallstrom A, Cappato R, Kadish AH, Kudenchuk PJ, Mark DB, Al-Khatib SM, Piccini JP, Inoue LYT, Sanders GD. Survival benefit of primary prevention implantable cardioverter-defibrillator therapy after myocardial infarction: Does time to implant matter? A meta-analysis using patient-level data from 4 clinical trials. Heart Rhythm 2013;10:828-835.
Hallstrom A, Kadish AH, Kudenchuk PJ, Lee KL, Mark DB, Moss AJ, Steinman R, Inoue LY, Sanders GD. Do patients with a left ventricular ejection fraction between 30% and 35% benefit from a primary prevention implantable cardioverter defibrillator? Int J Cardiol. 2014;172:253-254
7. Pun PH, Al-Khatib SM, Han JY, Edwards R, Bardy GH, Bigger JT, Buxton AE, Moss AJ, Lee KL,
Steinman R, Dorian P, Hallstrom A, Cappato R, Kadish AH, Kudenchuk PJ, Mark DB, Hess PL, Inoue LY, Sanders GD. Implantable cardioverter-defibrillators for primary prevention of sudden cardiac death in patients with CKD: a meta-analysis of patient-level data from 3 randomized trials. Am J Kidney Dis. 2014 Feb 8. pii: S0272-6386(14)00021-3. doi: 10.1053/j.ajkd.2013.12.009. [Epub ahead of print].
8. Hess PL, Al-Khatib SM, Han JY, Edwards R, Bardy GH, Bigger JT, Buxton A, Cappato R, Dorian
P, Hallstrom A, Kadish AH, Kudenchuk PJ, Lee KL, Mark DB, Moss AJ, Steinman R, Inoue LY, Sanders G. Survival Benefit of the Primary Prevention Implantable Cardioverter-Defibrillator Among Older Patients: Does Age Matter? An Analysis of Pooled Data From 5 Clinical Trials. Circ Cardiovasc Qual Outcomes. 2015 Feb 10; PMID: 25669833
9. Steinberg BA, Al-Khatib SM, Edwards R, Han J, Bardy GH, Bigger JT, Buxton AE, Moss AJ, Lee
KL, Steinman R, Dorian P, Hallstrom A, Cappato R, Kadish AH, Kudenchuk PJ, Mark DB, Inoue LY, Sanders GD. Outcomes of implantable cardioverter-defibrillator use in patients with comorbidities: results from a combined analysis of 4 randomized clinical trials. JACC Heart Fail. 2014 Dec;2(6):623-9. doi: 10.1016/j.jchf.2014.06.007. Epub 2014 Oct 8. PMID:25306452
Knoepke C, Lampert R, Mueller PS, Reynolds MR, Spertus JA, Stevenson LW, Mitchell SL. Implantable Cardioverter-Defibrillator Use in Older Adults: Proceedings of a Hartford Change AGEnts Symposium. Circ Cardiovasc Qual Outcomes. 2015 Jun 2. pii: CIRCOUTCOMES.114.001660. [Epub ahead of print] No abstract available. PMID: 26038525
11. Zeitler EP, Al-Khatib SM, Friedman DJ, Han JY, Poole JE, Bardy GH, Bigger JT, Buxton AE, Moss AJ, Lee KL, Dorian P, Cappato R, Kadish AH, Kudenchuk PJ, Mark DB, Inoue LYT, Sanders GD. Predicting appropriate shocks in patients with heart failure: Patient level meta-analysis from SCD-HeFT and MADIT II. J Cardiovasc Electrophysiol. 2017 Jul 26. doi: 10.1111/jce.13307. [Epub ahead of print]PMID: 28744959
12. Friedman DJ, Al-Khatib SM, Zeitler EP, Han J, Bardy GH, Poole JE, Bigger JT, Buxton AE, Moss AJ, Lee KL, Steinman R, Dorian P, Cappato R, Kadish AH, Kudenchuk PJ, Mark DB, Inoue LYT, Sanders GD. New York Heart Association class and the survival benefit from primary prevention implantable cardioverter defibrillators: A pooled analysis of 4 randomized controlled trials. Am Heart J. 2017 Sep;191:21-29. doi: 10.1016/j.ahj.2017.06.002. Epub 2017 Jun 9. PMID: 28888266
13. RESEARCH PUBLICATIONS WITHOUT NAMED AUTHORSHIP
1. Evans GT, Scheinman MM, Bardy G, et al: Predictors of in-hospital mortality after DC catheter ablation of atrioventricular junction: Results of a prospective, International, Multicenter Study. Circulation 84:1924-1937, 1991. (*member of the investigative team cited in the appendix of the manuscript).
2. The AVID Investigators: Antiarrhythmics versus defibrillators (AVID)-Rationale, design, and
methods. Am J Cardiol 75:470-475, 1995 3. The Antiarrhythmics versus Implantable Defibrillators (AVID) Investigators: A comparison of
antiarrhythmic-drug therapy with implantable defibrillators in patients resuscitated from near-fatal ventricular arrhythmias. N Engl J Med 1997;337:1576-1583.
4. Bardy GH, Lee KL, Mark DB et al. for the Sudden Cardiac Death in Heart Failure Trial (SCD-
HeFT) Investigators. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med 2005;352:225-237.
OTHER PEER-REVIEWED PUBLICATIONS EDITORIALS-INVITED: 1. Buxton AE, Josephson ME: Sudden cardiac death--A perspective. The Western J of Med
141:677-679, 1984. 2. Buxton AE. The use of multiple extrastimuli during programmed ventricular stimulation: how
many should be used? Int J Cardiol 7:86-91, 1985. . 3. Buxton AE. Sudden cardiac death--1986. Ann Int Med 104:716-718, 1986. 4. Buxton AE. Catheter ablation of atrioventricular bypass tracts: Still an investigational procedure.
Circulation 79:1388-1390,1989. 5. Buxton, AE. Antiarrhythmic Drugs: Good for premature ventricular complexes but bad for
patients? Ann Int Med 116:420-422, 1992. 6. Domanski MJ, Buxton AE. The Primary Prevention of Sudden Death in Patients with Coronary
Artery Disease. Ann Intern Med 119:1218-1220, 1993. 7. Buxton, AE. Programmed Stimulation of the Ventricles - Back to the Future. J Interventional
Cardiac Electrophysiology 1:282-285, 1997. 8. Buxton AE. The clinical use of implantable cardioverter defibrillators: Where are we now?
Where should we go? Ann Intern Med 138:512-514, 2003. 9. Buxton AE. Not everyone with an ejection fraction ≤30% should receive an implantable
10. Buxton AE. Sudden death after myocardial infarction – who needs prophylaxis and when? N Engl J Med. 352:2638-2640, 2005.
11. Buxton AE. Identifying the High Risk Patient with Coronary Artery Disease. Is Ejection
Fraction All You Need? J Cardiovasc Electrophysiology 16: S25-S27, Suppl I, 2005.
12. Buxton AE. Risk Stratification for Sudden Death in 2008: Where are we now? Where should we go? Editorial Comment on “Non-Invasive Risk Stratification Guidelines” Available in: American Heart Association Learning Library http://pt.wkhealth.com/pt/re/aha/addcontent.8880044.htm;jsessionid=L8dZn0c76vdH1P2jHJtTTHSvQnhLQh6hn5HqhF1Qmn8fvp280TmT!1484581744!181195628!8091!-1!1220320761029. Pub Date Thursday August 28, 2008.
13. Buxton AE. Implantable loop recorder in survivors of acute myocardial infarction. A glimpse of reality? Circulation 2010;122:1255-1257.
14. Buxton AE. Sudden cardiac death won’t go away: What are we to do? Heart Rhythm
2011;8:1183-1184. 15. Kramer DB, Buxton AE, Zimetbaum PJ. Time for a change--a new approach to ICD
replacement. N Engl J Med. 2012;366:291-293. 16. Buxton AE. Implantable cardioverter-defibrillators for primary prevention of sudden death: The
quest to identify patients most likely to benefit. J Am Coll Cardiol. 2012;60:1656-1658. 17. Goldberger JJ, Buxton AE. Personalized medicine versus guideline-based medicine. JAMA
2013;309:2559-2560. 18. Buxton AE. Programmed ventricular stimulation: Not dead. Circulation. 2014;129:831-833. BOOKS, BOOK CHAPTERS, AND REVIEWS 1. Buxton AE. The intensive care unit (in): Bennett JV and Brachman PS, ed., Hospital Infections,
Little, Brown and Company, Boston, MA, 1979. 2. Buxton AE, Josephson ME. Sudden cardiac death: Approaches to prevention. Berlex
Laboratories, Inc., Cedar Knolls, NJ, 1981. 3. Buxton AE. Nosocomial infection in the intensive care unit. Crit Care Update 10:32-37, 1982. 4. Buxton AE, Josephson ME. Recurrent sustained ventricular tachycardia. Cardiac Impulse Vol. 3,
No. 1, January 1982, Searle Laboratories. 5. Buxton AE, Waxman HL, Josephson ME. Electrical stimulation techniques to predict and assess
antiarrhythmic drug efficacy in patients with ventricular arrhythmias (in), Chronic Antiarrhythmic
edited by Rosen KM. Chicago, IL, Robert B. Morden, Inc. pp. 1-6 ,1982. 8. Josephson ME, Waxman HL, Buxton AE, Marchlinski FE. Electrophysiologically guided
approach to the pharmacologic treatment of ventricular tachycardia. (In) Proceedings from the Symposium on Tachycardia in Man. From Mechanism to Management, Madrid, Spain, October 28-29, 1982.
9. Josephson ME, Buxton AE, Waxman HL, Marchlinski FE. The mechanism of ventricular
tachycardia. (In) Proceedings from the Symposium on Tachycardia in Man. From Mechanism to Management. Madrid, Spain, October 28-29, 1982.
tachycardias: Role of intracardiac recording and pacing for therapeutic indications. (In) Cardiac Arrhythmias - From Diagnosis to Therapy, edited by Levy S, Scheinman MM. Mount Kisco, NY, Futura Publishing Company, Inc. pp. 391-419, 1984.
testing of survivors of cardiac arrest. (In) Sudden Cardiac Death, edited by Josephson ME. Philadelphia, PA, F.A. Davis Co., pp 171-178, 1985.
23. Roy D, Marchlinski FE, Doherty JU, Buxton AE, Josephson ME: Pharmacologic therapy for
survivors of sudden death based on programmed stimulation. (In) Sudden Cardiac Death, edited by Josephson ME. Philadelphia, PA, F.A. Davis Co., pp 179-186, 1985.
24. Buxton AE. Sudden death after MI--whose risk is greatest? DIAGNOSIS 7:70-76, 1985. 25. Buxton AE. Perioperative coronary spasm. (In) Advances in Cardiac Surgery, edited by Roberts
tachycardia. State-of-the-art consensus conference on electrophysiologic testing in the diagnosis and treatment of patients with cardiac arrhythmias. Circulation 75 (Supp III):III41-III47, 1987.
31. Josephson ME, Buxton AE, Marchlinski FE. The Tachyarrhythmias. (In) Harrison's Principles of
Internal Medicine edited by Braunwald E., New York, NY, McGraw-Hill Co., pp 923-938, 1987. 32. Buxton AE, Marchlinski FE, Rosenthal ME, Flores B, Miller JM, Josephson ME. Arrhythmogenic
effects of antiarrhythmic drugs: Role of electrophysiologic studies. Edited by Konrad Steinbach, Munich, Germany, pp 201-210, 1987.
33. Marchlinski FE, Almendral JM, Cassidy DM, Grogan EW, Miller JM, Vassallo JA, Buxton AE, Josephson ME. Localization of endocardial site for catheter ablation of ventricular
tachycardia. (In) Ablation in Cardiac Arrhythmias edited by Fontaine G, Scheinman MM. Mount Kisco, NY, Futura Publishing Co. Inc., Chapter 23, pp 289-309, 1987.
34. Simson MB, Kindwall KE, Buxton AE, Josephson ME: Signal-Averaging of the ECG in the
management of patients with ventricular tachycardia: Prediction of antiarrhythmic drug efficacy. From Brugada P., Wellens HJJ. Cardiac Arrhythmias: Where to Go From Here: Mount Kisco, NY, Futura Publishing Company, Inc., Chapter 17, pp 299-310, 1987.
35. Josephson ME, Miller JM, Vassallo JA, Almendral JM, Marchlinski FE, Buxton AE: The role of
electrophysiological studies in the management and therapy of recurrent ventricular tachycardias in patients with ischemic heart disease. (Chapter 23) (In) Aliot E, Lazzara R (Eds) Ventricular Tachycardias: From Mechanism to Therapy, Martinus Nijhoff/Dr W. Junk Publishers, Dordrecht/Boston/Lancaster, pp 309-328,1987.
Surgical therapy of ventricular tachycardia. (Eds) Hilger, Hombarh (In) Invasive Cardiovascular Therapy. Martinus Nijhoff Publishers, Cologne, Germany,pp. 555-566, 1987.
37. Josephson ME, Miller JM, Marchlinski FE, Buxton AE. Nonpharmacologic therapy of ventricular
tachycardia. Clin Cardiol 11:II-17-21, 1988. 38. Josephson ME, Buxton AE, Marchlinski FE, Miller JM, Orishimo TF: Therapy of ventricular
tachycardia: Role of electrophysiology studies 1987. Jpn J. Electrocardiology 8:2:121-139, 1988. 39. Josephson ME, Buxton AE, Almendral JM, Gottlieb CD: Electrophysiologic characteristics of
atrial flutter and their therapeutic implications. (Eds) Attuel P, Coumel P, Janse MJ (In) The Atruim in Health and Disease. Futura Publishing Company, Inc. Mount Kisco, NY. pp 95-132, 1989.
(In) Current Therapy in Internal Medicine, Third Edition. B.C. Decker, Inc. Philadelphia, PA, pp. 350-355, 1991.
43. Josephson ME, Marchlinski FE, Buxton AE. The bradyarrhythmias: Disorders of sinus node
function and AV conduction disturbances. (In) Wilson JD, Braunwald E, Fauci AS, Isselbacher KJ, Martin JB, Petersdorf RB, Root RK (Eds), Harrison's Principles of Internal Medicine, 12 Edition. New York, McGraw-Hill Book Company, pp. 902-908, 1991.
44. Josephson ME, Buxton AE, Marchlinski FE. The tachyarrhythmias, (In) Wilson JD, Braunwald
E, Fauci AS, Isselbacher KJ, Martin JB, Petersdorf RB, Root RK (Eds), Harrison's Principles of Internal Medicine, 12th Edition. New York, McGraw-Hill Book Company, pp. 908-923, 1991.
45. Buxton, AE. Late potentials and syncope. (In) El-Sherif N, Turitto G (eds), High-Resolution
Electrocardiography, Mount Kisco, NY, Futura Publishing Co., Inc., pp. 521-532, 1992 46. Grayboys TB, Buxton AE, Reiffel JA, Waldo AL: "Challenges in arrhythmia management: The
changing role of Class IA antiarrhythmics" A roundtable discussion. Hospital Formulary, Vol 27, Supplement 1, September 1992.
47. Hsia HH, Buxton AE: Workup and Management of Patients with sustained and nonsustained
monomorphic ventricular tachycardia. (In) Akhtar, M (ed.), Cardiology Clinics, Cardiac Arrhythmias and Related Syndromes: Current Diagnosis and Management, Volume 11, No. 1, February, 1993, Philadelphia, PA, W.B. Saunders Company, pp. 21-37
Josephson, ME and Wellens HJJ (ed.), Tachycardias: Mechanisms and Management, Mount Kisco, NY, Futura Publishing Co, Inc. pp 257-272, 1993
49. Buxton AE, Hurwitz JL: Disorders of cardiac rhythm and conduction in the medical intensive care
unit. (In) Carlson RW, Geheb MA (Eds) The Principles and Practices of Medical Intensive Care. Philadelphia, PA, W.B. Saunders Company, pp. 1049-1078, 1993.
50. Mitra RL, Buxton AE: The clinical significance of nonsustained ventricular tachycardia. Journal
of Cardiovascular Electrophysiology. 4:490-496,1993. 51. Buxton AE: The signal-averaged ECG in patients with nonsustained ventricular tachycardia - a
perspective. (In) Gomes JA (Ed). Signal Averaged Electrocardiography, Concepts, Methods, and Applications. Boston, MA, Kluwer Academic Publishers, pp.433-440, 1993.
Company, Philadelphia, pp. 363-375, 1994. 54. Buxton AE: Work-up and Assessment of Risk for Sudden Cardiac Death: Patients with
Nonsustained Ventricular Tachycardia. (In) Akhtar M, Myerburg RJ, Ruskin JN (eds), Sudden Cardiac Death, Prevalence, Mechanisms, and Approaches to Diagnosis and Management, Malvern PA, Williams and Wilkins, 1994.
55. Josephson ME, Marchlinski FE, Buxton AE: The bradyarrhythmias: Disorders of sinus node
function and AV conduction disturbances. (In) Wilson JD, Braunwald E, Fauci AS, Isselbacher KJ, Martin JB, Petersdorf RB, Root RK (Eds), Harrison's Principles of Internal Medicine, 13 Edition. New York, McGraw-Hill Book Company, 1994.
56. Josephson ME, Buxton AE, Marchlinski FE: The tachyarrhythmias. (In) Wilson JD, Braunwald
E, Fauci AS, Isselbacher KJ, Martin JB, Petersdorf RB, Root RK (Eds), Harrison's Principles of Internal Medicine, 13th Edition. New York, McGraw-Hill Book Company, 1994.
Podrid PJ and Kowey PR (Eds), Cardiac Arrhythmia. Mechanisms, Diagnosis, and Management. Baltimore, Williams & Wilkins, 1995.
58. Cossu SF, Buxton AE: The Clinical Spectrum of Ventricular Tachyarrhythmias in Patients with
Coronary Artery Disease: Relationship Between Clinical and Electrophysiologic Characteristics in Patients with Nonsustained and Sustained Ventricular Tachycardia and Cardiac Arrest. Cardiology in Review. 3:240-250, 1995.
59. Buxton AE : Ongoing Risk Stratification Trials: The Primary Prevention of Sudden Death.
Controlled Clinical Trials 17:S47-51, 1996. 60. Miller JM, Cossu SF, Chmielewski IL, Hsia HH, Rothman SA, Vogel RL, Buxton AE: Primary
Ablation of Atrial Flutter and Atrial Fibrillation. Cardiology Clinics 14:569-590, 1996. 61. Buxton AE: The primary prevention of sudden cardiac death: Prospective identification of the
problem. Noninvasive and invasive techniques for risk stratification. (In) Dunbar SB, Ellenbogn KA, and Epstein AE (Eds), Sudden Cardiac Death. Past, Present, and Future. Armonk, NY, Futura Publishing Company, Inc., 119-147, 1997.
and Greene HL (Eds), Current Therapy in Adult Medicine, Fourth Edition. Mosby, St. Louis, MO, 372-377, 1997.
63. Josephson ME, Zimetbaum P, Marchlinski FE, Buxton AE. The bradyarrhythmias: Disorders of
sinus node function and AV conduction disturbances. (In) Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL (Eds), Harrison's Principles of Internal Medicine, 14th Edition. New York, McGraw-Hill Book Company, 1998.
56
64. Josephson ME, Zimetbaum P, Buxton AE, Marchlinski FE. The tachyarrhythmias. (In) Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL (Eds), Harrison's Principles of Internal Medicine, 14th Edition. New York, McGraw-Hill Book Company, 1998.
65. Wald J and Buxton AE: Unusual Forms of Ventricular Tachycardia. Cardiology in Review,
6:255-266, 1998. 66. Altemose GT and Buxton AE: Idiopathic Ventricular Tachycardia. Annual Review of Medicine
50:159-177, 1999. 67. Buxton AE: Indications for the Implanted Cardioverter/Defibrillator – An Update. Harrison’s
Textbook of Medicine Online, June, 1999 68. Buxton AE, Duc J, Berger EE, Torres V: Nonsustained ventricular tachycardia. Cardiology
4:162-165, 2000. 70. Buxton AE and Lee KL: The Multicenter Unsustained Tachycardia Trial (MUSTT): A
randomized, controlled trial of the primary prevention of sudden death in patients with coronary artery disease. (In) Woosley RL and Singh SN (eds), Arrhythmia Treatment and Therapy. New York, Marcel Dekker, Inc., 2000, 301-315.
71. Josephson ME, Callans DJ, Buxton AE. The role of the implantable cardioverter-defibrillator for
prevention of sudden cardiac death. Ann Intern Med 133:901-910, 2000. 72. Buxton AE, Kirk MM, Michaud GF. Current approaches to evaluation and management of
patients with ventricular arrhythmias. Medicine and Health Rhode Island 2001;84:58-62.
73. Weigner MJ, Buxton AE. Nonsustained ventricular tachycardia: A guide to the clinical significance and management. Med Clin North America 2001;85:305-320.
74. Buxton AE, Duc J. Ventricular premature depolarizations and nonsustained ventricular
tachycardia. (In) Podrid PJ and Kowey PR (eds), Cardiac Arrhythmia. Mechanisms, Diagnosis and Management, Second Edition. Philadelphia, Lippincott Williams & Wilkins, 2001, 549-571.
75. Buxton AE. Indications for the Implanted Cardioverter/Defibrillator – An Update. (In) Braunwald
E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL (eds) Harrison’s Online Textbook of Medicine. McGraw-Hill, 2001.
76. Buxton AE, Kirk MM, Michaud GF, Pamidi M. Nonsustained Ventricular Tachycardia Update:
Epidemiology, Pathophysiology, Immediate Evaluation and management, Long-term management, experimental and theoretical. (In) Lazzara R (ed) Cardiac Electrophysiology Review 2001;5:323-327.
57
77. Buxton AE. Indications for the Implanted Cardioverter Defibrillator. (In) Braunwald E (ed) Harrison’s Advances in Cardiology. McGraw-Hill, 2002.
78. Buxton AE, Kirk MM, Michaud GF, Ellison KE, Nyren L. Management of the non-inducible
patient. (In) Packer DL (ed) Cardiac Electrophysiology Review 2002;6:466-471. 79. Buxton AE, Ellison KE, Kirk MM, Frain B, Koo C, Gandhi G, Khouzam S. Primary prevention of
sudden cardiac death: trials in patients with coronary artery disease. J Interv Card Electrophysiol. 2003 Oct;9(2):203-6.
80. Buxton AE. Trials of implantable cardiac defibrillators (ICDs) in patients with congestive heart
failure (nonbiventricular). (In) Ellenbogen KA, Kay GN, Wilkoff BL (ed) Device Therapy for Congestive Heart Failure. Saunders, 2003.
81. Buxton, AE. Risk Stratification for Sudden Death: Do We Need Anything More Than Ejection
Fraction? Cardiac Electrophysiology Review. 2003 7:434-7. 82. Buxton, AE. Clinical Trials of ICDs and AEDs. (In) Zipes DP and Jalife J. (ed) Cardiac
Electrophysiology, From Cell to Bedside, 4th edition. Saunders, 2004. 83. Buxton AE. Direct current cardioversion for atrial fibrillation and flutter. Med Health R I. 2004
Apr;87(4):97. 84. Buxton AE. Atrial fibrillation and flutter: overview. Med Health R I. 2004 Apr;87(4):92-3.
85. Chow AWC and Buxton AE (eds). Implantable Cardiac Pacemakers and Defibrillators. All You
Wanted to Know. Blackwell Publishing. Oxford. 2006 86. Buxton AE. Indications for the implanted cardioverter-defibrillator. In Chow AWC and Buxton
AE (eds) Implantable Cardiac Pacemakers and Defibrillators. All You Wanted to Know. Blackwell Publishing. Oxford. 2006 81-96.
87. Buxton AE. Implantable cardioverter-defibrillators should be used routinely in the elderly. Am J
Geriatr Cardiol 2006;15:361-4.
88. Buxton AE, Joventino L. Risk Stratification for Sudden Death in Patients with Coronary Artery Disease. In Gussak I and Antzelevitch C (eds). Electrical Disease of the Heart. Genetics, Mechanisms, Treatment, Prevention. Springer-Verlag London 2007.
89. Buxton AE, Original Review - Risk stratification for sudden death in patients with coronary artery
disease. Heart Rhythm 2009;6:836-847. 90. Buxton AE, Ellison KE, Lorvidhaya P, Ziv O. Left ventricular ejection fraction for sudden death
91. Lorvidhaya P, Buxton AE. Nonsustained ventricular tachycardia. In Yan G-X and Kowey PR (eds). Management of Cardiac Arrhythmias - Second Edition. Humana Press (Springer Science + Business Media, New York) 2010.
92. Buxton AE, Ellison KE, Lorvidhaya P, Ziv O. Left ventricular ejection fraction for sudden death
Kääb S, La Rovere MT, Malik M, Myerburg RJ, Simoons ML, Swedberg K, Tijssen J, Voors AA, Wilde AA. Risk stratification for sudden cardiac death: current status and challenges for the future. Eur Heart J. 2014;35:1642-1651. PMID: 24801071
95. Levine YC, Buxton AE. The evaluation and management of non-sustained ventricular tachycardia
in patients after myocardial infarction. Chapter in Daoud EG and Kalbfleisch SJ (eds.) Color Atlas and Synopsis of Electrophysiology. McGraw Hill Education. New York, 2015; 120-124.
96. Buxton AE, Waks JW, Shen C, Chen PS. Risk stratification for sudden cardiac death in North
America - current perspectives. J Electrocardiol. 2016;49:817-823. PMID: 27524476
97. Buxton AE. Multifocal atrial tachycardia. Chapter in UpToDate. 2012-present.
99. Ganz LI, Buxton AE. Sustained monomorphic ventricular tachycardia: Clinical manifestations, diagnosis, and evaluation. Chapter in UpToDate. 2016-present.
100. Buxton AE, Ganz LI. Sustained monomorphic ventricular tachycardia in patients with a prior myocardial infarction: Treatment and prognosis. Chapter in UpToDate. 2013-present.
101. Buxton AE. Sudden death in ischemic heart disease – 2017. Int J Cardiol. 2017; 237: 64-66. PMID: 28365181
102. Shenasa M, Miller JM, Callans DJ, Almendral JM, Marchlinski FE, Buxton AE. Conquest of Ventricular Tachycardia: Insights Into Mechanisms, Innovations in Management: Contribution of Mark E. Josephson, MD, to Clinical Electrophysiology. Circ Arrhythm Electrophysiol. 2017;10(5). pii: e005150. doi: 10.1161/CIRCEP.117.005150. PMID:28487348
103. Sroubek J, Buxton AE. Primary prevention implantable cardiac defibrillator trials – What have we learned? Cardiac Electrophysiology Clinics. 2017;9:761-773.
104. Waks JW, Buxton AE. Risk stratification for sudden cardiac death after myocardial infarction. Annual Review of Medicine 2018;69 – In press
105. Zimetbaum PJ, Buxton AE, Josephson ME (eds). Practical Clinical Electrophysiology. Second Edition. Wolters Kluwer. Philadelphia 2018
CASE REPORTS 1. Fraser DW, Buxton AE, Naji A, Rudnick M, Barker CF, Weinstein AJ: Disseminated Myco-
bacterium kansasii infection presenting as cellulitis in a recipient of a renal homograft. Am Rev Resp Dis 112:125-129, 1975.
2. Buxton AE, Morganroth J, Josephson ME, Perloff J, Shelburne JC: Isolated dextroversion of the
heart with asymmetric septal hypertrophy. Am Heart J 92:785-79, 1976. 3. Nicholson WJ, Buxton AE, Tammaro D. Bradycardic syncope in 2 patients who recently began
gatifloxacin treatment.. Clin Infect Dis. 2003;36:e35-9. 4. Tan AY, Abdi S, Buxton AE, Anter E. Percutaneous stellate ganglion block for acute conrol of
refractory ventricular tachycardia. Heart Rhythm 2012;9:2063-2067. 5. Warraich HJ, Buxton AE, Kociol RD. Macroscopic T-wave alternans in a patient with Takotsub’s
cardiomyopathy and QT prolongation. Heart Rhythm 2014 Mar 4. pii: S1547-5271(14)00238-0. doi: 10.1016/j.hrthm.2014.03.005. [Epub ahead of print]. PMID: 24607719
ACC/AHA Clinical Competence Statement on Electrocardiography and Ambulatory Electrocardiography. J Am Coll Cardiol 2001;38:2091-2100.
3. Zipes DP, Camm AJ, Borggrefe M, Buxton AE, Chaitman B, Fromer M, Gregoratos G, Klein G,
Moss AJ, Myerburg RJ, Priori SG, Quinones MA, Roden DM, Silka MJ, Tracy C. ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death). J Am Coll Cardiol 2006;48:e247– e346.
60
4. Zipes DP, Camm AJ, Borggrefe M, Buxton AE, Chaitman B, Fromer M, Gregoratos G, Klein G,
Moss AJ, Myerburg RJ, Priori SG, Quinones MA, Roden DM, Silka MJ, Tracy C. ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death—executive summary: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death). J Am Coll Cardiol 2006;48:1064 –1108.
5. Buxton AE, Calkins H, Callans DJ, Dimarco JP, Fisher JD, Greene HL, Haines DE, Hayes DL,
Heidenreich PA, Miller JM, Poppas A, Prystowsky EN, Schoenfeld MH, Zimetbaum PJ, Heidenreich PA, Goff DC, Grover FL, Malenka DJ, Peterson ED, Radford MJ, Redberg RF. ACC/AHA/HRS 2006 Key Data Elements and Definitions for Electrophysiological Studies and Procedures. A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Data Standards (ACC/AHA/HRS Writing Committee to Develop Data Standards on Electrophysiology). Circulation. 2006;114:2534-2570.
6. Fishman GI, Chugh S, DiMarco JP, Albert CM, Anderson ME, Bonow RO, Buxton AE, Chen P-S,
Estes M, Jouven X, Kwong R, Lathrop DA, Mascette AM, Nerbonne JM, O’Rourke B, Page RL, Roden DM, Rosenbaum DS, Sotoodehnia N, Trayanova NA, Zheng Z-J. Special Report. Sudden Cardiac Death Prediction and Prevention: Report from a National Heart Lung and Blood Institute and Heart Rhythm Society Workshop. Circulation. 2010; 122:2335-2348.
7. Goldberger JJ, Buxton AE, Cain M, Costantini O, Exner DV, Knight BP, Lloyd-Jones D, Kadish AH, Lee B, Moss A, Myerburg R, Olgin J, Passman R, Rosenbaum D, Stevenson W, Zareba W, Zipes DP. Risk stratification for arrhythmic sudden cardiac death: identifying the roadblocks. Circulation 2011;123:2423-2430.
8. Weintraub WS, Karlsberg RP, Tcheng JE, Boris JR, Buxton AE, Dove JT, Fonarow GC, Goldberg LR, Heidenreich P, Hendel RC, Jacobs AK, Lewis W, Mirro MJ, Shahian DM. ACCF/AHA 2011 key data elements and definitions of a base cardiovascular vocabulary for electronic health records: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Clinical Data Standards. J Am Coll Cardiol. 2011;58:202-222.
9. Bonow RO, Douglas PS, Buxton AE, Cohen DJ, Curtis JP, DeLong E, Drozda JP et al. ACCF/AHA Methodology for the development of quality measures for cardiovascular technology: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Performance Measures. Circulation. 2011;124:1483-1502.
10. Goldberger JJ, Basu A, Boineau R, Buxton AE, Cain ME, Canty JM Jr, Chen PS, Chugh SS,
Costantini O, Exner DV, Kadish AH, Lee B, Lloyd-Jones D, Moss AJ, Myerburg RJ, Olgin JE, Passman R, Stevenson WG, Tomaselli GF, Zareba W, Zipes DP, Zoloth L. Risk stratification for sudden death: a plan for the future. Circulation. 2014;129:516-526.
Welikovitch L. HRS/ACC/AHA Expert consensus statement on the use of implantable cardioverter-defibrillator therapy in patients who are not included or not well represented in clinical trials. Circulation. 2014;130:94-125. PMID: 24815500
12. Sciammarella MG, Gerson M, Buxton AE, Bartley SC, Doukky R, Merlino DA, Tandon S,
Abstracts, Poster Presentations and Exhibits Presented at Professional Meetings (last 3 years only):
1. Rayatzadeh H, Tan A, Hauser T, Shaw J, Patel S, Hong S, Chan R, Zimetbaum P, Buxton A,
Josephson M, Manning W, Nezafat R. Scar heterogeneity on cardiac magnetic resonance imaging is a predictor of appropriate implantable cardioverter defibrillator therapy: 10 years of experience. J Am Coll Cardiol 2012;59:E108
2. Hess PL, Laird A, Edwards R, Bardy GH, Bigger JT, Buxton AE, Moss AJ, Lee KL, Hall WJ,
Steinman R, Dorian P, Hallstrom A, Cappato R, Kadish AH, Kudenchuk PJ, Mark DB, Al-Khatib SM, Piccini JP, Inoue LYT, Sanders GD. Mortality benefit of primary prevention implantable cardioverter-defibrillators as a function of time after myocardial infarction: A meta-analysis using patient-level data on 3,038 patients enrolled in 5 clinical trials. Heart Rhythm 2012;9:S369
3. Anter E, Tan A, Abdi S, Nagda JV, Buxton A, Zimetbaum P, Haffajee C, Chang J, Josephson ME.
Minimally-invasive “test-dose” stellate ganglion block for assessment of sympathectomy for control of ventricular tachycardia. Heart Rhythm 2012;9:S479.
Lee KL, Hall WJ, Steinman R, Dorian P, Hallstrom AP, Cappato R, Kadish AH, Kudenchuk PJ, Mark DB, Inoue LYT, Sanders G. Implantable cardiac defibrillator therapy in patients with comorbidities: Results from a combined analysis of five randomized clinical trials. Heart Rhythm 2013;10:S60.
5. Levine YC, Mittleman M, Rosenberg M, Buxton AE. N-terminal Pro-B-Type natriuretic peptide
is a major predictor of appropriate ICD therapy. Heart Rhythm 2013;10:S209. 6. Sanders GD, Inoue LYT, Edwards R, Al-Khatib SM, Han JY, Bardy GH, Bigger JT, Buxton AE,
Moss AJ, Lee KL, Steinman R, Dorian P, Hallstrom A, Cappato R, Kadish AH, Kudenchuk PJ, Mark DB. Harnessing the Power of Bayesian Statistics and Patient-Level Data to Predict the Effectiveness of Implantable Cardioverter Defibrillator (ICD) Therapy in Patient Subgroups. Society for Medical Decision Making 35th Annual Meeting, Baltimore MD, October 2013 (in press)
7. Hoang A, Shen C, Zheng J, Taylor S, Rosenman M, Buxton A, Chen P-S. Utilization Rates of
Primary Prevention Implantable Cardioverter-Defibrillators: a 2012 Calculation for a Midwestern Health Referral Region. American Heart Association Annual Scientific Sessions, November 19, 2013
8. Levine YC, Goldberg R, Samuel M, Buxton AE. Recovery of left ventricular ejection fraction
after ICD implantation does not affect ongoing risk of appropriate ICD therapy. Heart Rhythm 2014;11:S76.
9. Waks JW, Mittleman M, Buxton AE. Differential effect of prior ventricular arrhythmia among
patients with primary prevention and secondary prevention implantable cardioverter-defibrillators at the time of first generator replacement. Heart Rhythm 2014;11:S117.
10. Anter E, Contreras Valdes F, Buxton AE, Josephson ME. Atrial fibrillation in patients with
hypertrophic cardiomyopathy: Outcome of pulmonary vein isolation. Heart Rhythm 2014;11:S120.
11. Waks JW, Mittleman M, Buxton AE. Comparative influence of renal function on mortality and
ventricular arrhythmias in patients undergoing first implantable cardioverter-defibrillator generator replacement. Heart Rhythm 2014;11:S184.
12. Levine YC, Rosenberg MA, Samuel M, Buxton AE. Reduced incidence of appropriate ICD
therapies in elderly patients with primary prevention ICDs. Heart Rhythm 2014;11:S302. 13. Tan AYH, Nearing BD, Ellis E, Nezafat R, Rosenberg M, Buxton AE, Josephson ME, Verrier RL.
Elevated spatial R and T wave heterogeneity is associated with increased risk for sustained ventricular tachyarrhythmia and death in patients with cardiomyopathy. Heart Rhythm 2014;11:S466.
14. Matos JD, Levine YC, Josephson ME, Manning WJ, Buxton AE. A novel index of left
15. Anter E, Tschabrunn CM, Buxton AE, Josephson ME. In-vivo high-resolution mapping of post-infarction reentrant ventricular tachcyardias. Heart Rhythm 2015;12:S203. 16. Anter E, Tschabrunn CM, Buxton AE, Josephson ME. Isthmus characteristics of reentrant ventricular tachycardia in healed myocardial infarction. Heart Rhythm 2015;12:S204. 17. Anter E, Josephson ME, Buxton AE, Tschabrunn CM, McElderry TH, Awad KA, Gunter A, Mounsey JP, Kumar P, Nakagawa H. Rhythmia mapping system: feasibility, safety and short-term efficacy in left atrial procedures – the initial multicenter experience in the US. Heart Rhythm 2015;12:S266.
63
18. Levine YC, Tuttle MK, Rosenberg MA, Samuel M, Kramer DB, Buxton AE. Prevalence and outcomes of patients with non-guideline-based primary prevention ICDs in practice. Heart Rhythm 2015;12:S332. 19. Witt C, Waks JW, Kramer DB, Buxton AE, Hu TY, Lushinsky EC, Mulholland MB, Hodge DO, Mehta RA, Friedman PA, Gersh, BJ, Madhavan M. Appropriate implantable cardioverter-defibrillator therapy and mortality after generator replacement: A competing risk analysis. Heart Rhythm 2016;13:S173. 20. Waks JW, Sitlani CM, Soliman EZ, Kabir M, Ghafoori E, Biggs ML, Henrikson CA, Sotoodehnia N, Biering-Sorensen T, Agarwal SK, Siscovick D, Post WS, Solomon SD, Buxton AE, Josephson ME, Tereshchenko LG. Global electrical heterogeneity risk score for prediction of sudden cardiac death in the general population: The Atherosclerosis Risk in Communities (ARIC) and Cardiovascular Health (CHS) Studies. Heart Rhythm 2016;13:S334. Narrative Report Research My interests have focused on understanding mechanisms of cardiac arrhythmias, particularly ventricular arrhythmias, and applying understanding of mechanisms to developing improved methods to identify patients at high risk for sudden cardiac death. I strongly believe that only through better understanding of the diverse pathophysiology responsible for ventricular tachyarrhythmias will be able to apply prophylactic therapies, such as implantable defibrillators, in a logical, cost-effective manner. My work in this area began in the early 1980s under the mentorship of Dr. Mark Josephson. I used electrophysiologic studies and standard ECG recording techniques to characterize types of non-sustained ventricular tachycardia. Longitudinal follow-up studies revealed the importance of underlying heart disease and ventricular function on the prognostic significance of non-sustained ventricular tachycardia. In 1983 I was the first to describe the fact that most non-sustained ventricular tachycardias in persons without structural heart disease originated from the right ventricular outflow tract. In 1984 I described the occurrence of repetitive monomorphic ventricular tachycardia in patients without structural heart disease, usually originating from the right ventricular outflow tract, but also demonstrated that similar rhythms could occur in patients following myocardial infarction. I then published one of the first descriptions of the systematic use of programmed stimulation to inform prognosis of patients with coronary artery disease. This work formed the basis for the NIH-funded “Multicenter UnSustained Tachycardia Trial” (MUSTT), for which I served as the Principal Investigator. This trial, begun in 1990, took a decade to complete, and established the utility of programmed stimulation for risk stratification of patients with coronary disease. It also demonstrated that electrophysiologic testing could not be used to predict the ability of antiarrhythmic drugs to provide long-term freedom from sudden death in at-risk patients with coronary artery disease. For the past several years I have been part of an international working group seeking to refine methods of risk stratification for sudden death. I currently have pending an application before the NHLBI for a multicenter trial to test a simple, readily-applied model to enhance utility of implantable defibrillators in patients with abnormal systolic ventricular function. I have also recently studied structure-function relations underlying development of ventricular tachyarrhythmias in patients with myocardial infarction, using cardiac magnetic resonance imaging. I plant to continue this work in the near future.
64
Teaching I have directed clinical electrophysiology training programs at the University of Pennsylvania, and Temple University in the past. Over the past decade I built a clinical electrophysiology fellowship around a complete curriculum spanning basic science to clinical science at Brown University that has attracted very high quality candidates from around the country. I have developed a very well regarded curriculum in cardiac arrhythmias and electrocardiography for the Brown Medical School. In addition to serving as clinical and research mentor for the clinical electrophysiology fellows I have trained, I served on the advisory committee for the NIH T32 in Behavioral Medicine at Brown University and mentor for post-doc trainee Eva Serber, PhD. After completing her 2 year post-doc studies on the T32, Dr. Serber was given a faculty position at Brown in Behavioral Medicine. She secured a R21 grant, on which I serve as Co-Investigator. Clinical I have maintained a practice of clinical electrophysiology since 1981. After serving as Director of the Clinical Electrophysiology Laboratory at the University of Pennsylvania for 10 years, I helped a colleague establish a similar, but smaller program at Temple University. In 1999 I moved to Providence and built a Clinical Electrophysiology/Arrhythmia Program. I have a busy outpatient and inpatient consultative service, in addition to performing every type of catheter ablation procedure. My goals in moving to Beth Israel Deaconess Medical Center are to work with the faculty to further develop the Arrhythmia/Electrophysiology service, bring new approaches to training the fellows in Clinical Cardiology and Electrophysiology, as well as enhance interactions with housestaff and medical students. I hope to inspire more trainees to follow academic careers in Cardiology, and specifically electrophysiology. I will develop a database/reporting system for the clinical electrophysiology lab and service that will harmonize with the hospital record system, as well as facilitate clinical research. Finally, my major scientific goal is to develop logical, physiologic algorithms to guide physicians in risk stratification of patients at risk for sudden cardiac death.
