342

" XBD=150 XHG=79 YBD=228 YHG=193>the " XBD=308 XHG=166 YBD=229 YHG=193>other : " XBD=511 XHG=342 YBD=236 YHG=194>O.E.D.) " XBD=574 XHG=529 YBD=228 YHG=196>to " XBD=798 XHG=590 YBD=238 YHG=193>designate " XBD=884 XHG=813 YBD=226 YHG=192>the " XBD=980 XHG=899 YBD=227 YHG=196>two " XBD=1146 XHG=995 YBD=238 YHG=193>parties " XBD=1206 XHG=1161 YBD=228 YHG=196>to " XBD=1276 XHG=1222 YBD=227 YHG=204>an" XBD=311 XHG=80 YBD=287 YHG=241>exchange ; " XBD=421 XHG=340 YBD=276 YHG=242>and " XBD=516 XHG=434 YBD=275 YHG=241>this " XBD=655 XHG=528 YBD=275 YHG=252>seems " XBD=721 XHG=668 YBD=275 YHG=252>an " XBD=989 XHG=732 YBD=286 YHG=241>appropriate " XBD=1121 XHG=998 YBD=282 YHG=240>word, " XBD=1277 XHG=1132 YBD=287 YHG=243>except" XBD=174 XHG=79 YBD=324 YHG=289>that " XBD=247 XHG=204 YBD=324 YHG=290>in " XBD=348 XHG=277 YBD=324 YHG=286>the " XBD=533 XHG=378 YBD=324 YHG=289>United " XBD=702 XHG=564 YBD=330 YHG=288>States " XBD=767 XHG=732 YBD=322 YHG=289>it " XBD=1105 XHG=798 YBD=334 YHG=288>unfortunately " XBD=1277 XHG=1136 YBD=325 YHG=301>means" XBD=309 XHG=83 YBD=382 YHG=337>something " XBD=496 XHG=340 YBD=371 YHG=337>else-a " XBD=815 XHG=528 YBD=372 YHG=336>season-ticket " XBD=995 XHG=845 YBD=373 YHG=337>holder. " XBD=1091 XHG=1050 YBD=373 YHG=338>It " XBD=1156 XHG=1121 YBD=373 YHG=338>is " XBD=1275 XHG=1186 YBD=384 YHG=349>sug-" XBD=222 XHG=82 YBD=431 YHG=386>gested " XBD=352 XHG=258 YBD=419 YHG=385>that " XBD=648 XHG=390 YBD=426 YHG=387>commuters, " XBD=801 XHG=685 YBD=420 YHG=385>while " XBD=1071 XHG=839 YBD=432 YHG=385>sojourning " XBD=1276 XHG=1109 YBD=429 YHG=387>abroad," XBD=228 XHG=84 YBD=469 YHG=433>should " XBD=396 XHG=242 YBD=467 YHG=433>receive " XBD=694 XHG=411 YBD=468 YHG=433>maintenance " XBD=925 XHG=710 YBD=471 YHG=434>allowance " XBD=982 XHG=939 YBD=469 YHG=435>in " XBD=1068 XHG=996 YBD=470 YHG=435>the " XBD=1277 XHG=1084 YBD=481 YHG=446>currency" XBD=139 XHG=84 YBD=523 YHG=482>of, " XBD=246 XHG=165 YBD=516 YHG=482>and " XBD=485 XHG=272 YBD=527 YHG=482>according " XBD=555 XHG=510 YBD=516 YHG=485>to " XBD=651 XHG=580 YBD=517 YHG=482>the " XBD=836 XHG=679 YBD=519 YHG=486>custom " XBD=915 XHG=861 YBD=526 YHG=484>of, " XBD=1012 XHG=941 YBD=518 YHG=484>the " XBD=1211 XHG=1039 YBD=529 YHG=487>country " XBD=1277 XHG=1233 YBD=518 YHG=485>in" XBD=213 XHG=84 YBD=564 YHG=530>which " XBD=348 XHG=247 YBD=575 YHG=530>they " XBD=440 XHG=373 YBD=564 YHG=541>are " XBD=657 XHG=466 YBD=576 YHG=530>working. " XBD=810 XHG=725 YBD=566 YHG=531>The " XBD=1056 XHG=845 YBD=577 YHG=543>necessary " XBD=1277 XHG=1089 YBD=568 YHG=532>financial" XBD=385 XHG=83 YBD=624 YHG=581>arrangements " XBD=536 XHG=402 YBD=613 YHG=578>would " XBD=605 XHG=554 YBD=614 YHG=579>be " XBD=742 XHG=624 YBD=614 YHG=580>made " XBD=818 XHG=761 YBD=625 YHG=580>by " XBD=905 XHG=835 YBD=615 YHG=581>the " XBD=1125 XHG=924 YBD=625 YHG=584>secretary " XBD=1189 XHG=1144 YBD=615 YHG=580>of " XBD=1274 XHG=1202 YBD=615 YHG=581>the" XBD=237 XHG=85 YBD=661 YHG=627>bureau " XBD=297 XHG=250 YBD=661 YHG=627>in " XBD=589 XHG=315 YBD=663 YHG=627>consultation " XBD=704 XHG=605 YBD=663 YHG=628>with " XBD=792 XHG=721 YBD=664 YHG=628>the " XBD=1011 XHG=810 YBD=674 YHG=632>secretary " XBD=1073 XHG=1028 YBD=663 YHG=628>of " XBD=1157 XHG=1086 YBD=663 YHG=629>the " XBD=1277 XHG=1174 YBD=663 YHG=627>local" XBD=236 XHG=85 YBD=710 YHG=675>branch " XBD=306 XHG=260 YBD=712 YHG=675>of " XBD=393 XHG=323 YBD=711 YHG=676>the " XBD=671 XHG=415 YBD=719 YHG=677>association, " XBD=777 XHG=695 YBD=712 YHG=678>and " XBD=869 XHG=798 YBD=712 YHG=677>the " XBD=1120 XHG=892 YBD=713 YHG=677>secretaries " XBD=1188 XHG=1142 YBD=711 YHG=676>of " XBD=1277 XHG=1205 YBD=711 YHG=677>the" XBD=187 XHG=83 YBD=760 YHG=724>local " XBD=400 XHG=205 YBD=760 YHG=725>branches " XBD=552 XHG=418 YBD=761 YHG=725>would " XBD=675 XHG=569 YBD=761 YHG=726>have " XBD=746 XHG=693 YBD=761 YHG=738>an " XBD=836 XHG=764 YBD=772 YHG=738>eye " XBD=899 XHG=854 YBD=762 YHG=729>to " XBD=986 XHG=915 YBD=761 YHG=726>the " XBD=1176 XHG=1006 YBD=761 YHG=725>comfort " XBD=1276 XHG=1194 YBD=761 YHG=724>and" XBD=308 XHG=83 YBD=820 YHG=774>well-being " XBD=370 XHG=324 YBD=810 YHG=775>of " XBD=627 XHG=382 YBD=810 YHG=778>commuters " XBD=685 XHG=641 YBD=809 YHG=774>in " XBD=807 XHG=701 YBD=810 YHG=775>their " XBD=992 XHG=822 YBD=810 YHG=775>district. " XBD=1289 XHG=1285 YBD=780 YHG=774>’" XBD=231 XHG=136 YBD=863 YHG=828>This " XBD=418 XHG=249 YBD=874 YHG=829>project, " XBD=477 XHG=440 YBD=863 YHG=828>if " XBD=676 XHG=493 YBD=870 YHG=828>fulfilled, " XBD=772 XHG=697 YBD=864 YHG=840>can " XBD=931 XHG=787 YBD=873 YHG=828>hardly " XBD=1019 XHG=948 YBD=862 YHG=827>fail " XBD=1081 XHG=1037 YBD=862 YHG=829>to " XBD=1147 XHG=1096 YBD=862 YHG=828>be " XBD=1277 XHG=1165 YBD=862 YHG=828>valu-" XBD=177 XHG=87 YBD=912 YHG=876>able " XBD=232 XHG=189 YBD=912 YHG=877>in " XBD=400 XHG=243 YBD=923 YHG=877>forging " XBD=518 XHG=411 YBD=912 YHG=878>links " XBD=713 XHG=530 YBD=912 YHG=878>between " XBD=898 XHG=725 YBD=912 YHG=877>workers " XBD=952 XHG=909 YBD=911 YHG=877>in " XBD=1046 XHG=963 YBD=911 YHG=876>this " XBD=1278 XHG=1058 YBD=921 YHG=876>particular" XBD=178 XHG=84 YBD=961 YHG=925>field " XBD=236 XHG=191 YBD=961 YHG=926>of " XBD=452 XHG=243 YBD=968 YHG=926>medicine, " XBD=548 XHG=466 YBD=961 YHG=926>and " XBD=594 XHG=560 YBD=961 YHG=926>it " XBD=686 XHG=606 YBD=963 YHG=925>will " XBD=912 XHG=699 YBD=960 YHG=926>command " XBD=994 XHG=924 YBD=959 YHG=924>the " XBD=1278 XHG=1007 YBD=970 YHG=924>sympathetic" XBD=291 XHG=87 YBD=1011 YHG=975>attention " XBD=399 XHG=318 YBD=1010 YHG=975>and " XBD=597 XHG=427 YBD=1023 YHG=978>support " XBD=670 XHG=625 YBD=1009 YHG=974>of al who " XBD=986 XHG=888 YBD=1008 YHG=973>wish " XBD=1075 XHG=1012 YBD=1007 YHG=973>for " XBD=1172 XHG=1100 YBD=1008 YHG=973>the " XBD=1276 XHG=1198 YBD=1008 YHG=973>dis-" XBD=335 XHG=85 YBD=1071 YHG=1032>appearance " XBD=419 XHG=373 YBD=1059 YHG=1024>of " XBD=635 XHG=453 YBD=1059 YHG=1023>national " XBD=855 XHG=673 YBD=1058 YHG=1023>barriers. " XBD=993 XHG=909 YBD=1057 YHG=1023>The " XBD=1197 XHG=1030 YBD=1057 YHG=1022>method " XBD=1282 XHG=1236 YBD=1057 YHG=1021>of" XBD=290 XHG=86 YBD=1119 YHG=1073>approach " XBD=496 XHG=318 YBD=1118 YHG=1073>adopted " XBD=581 XHG=524 YBD=1117 YHG=1073>by " XBD=678 XHG=607 YBD=1107 YHG=1072>the " XBD=862 XHG=707 YBD=1106 YHG=1070>clinical pathologists " XBD=1278 XHG=1181 YBD=1116 YHG=1081>may" XBD=399 XHG=86 YBD=1157 YHG=1121>well-commend " XBD=524 XHG=410 YBD=1156 YHG=1121>itself " XBD=578 XHG=532 YBD=1156 YHG=1124>to " XBD=708 XHG=592 YBD=1155 YHG=1121>other " XBD=902 XHG=721 YBD=1155 YHG=1120>societies " XBD=1091 XHG=916 YBD=1155 YHG=1119>devoted " XBD=1148 XHG=1103 YBD=1154 YHG=1122>to " XBD=1278 XHG=1163 YBD=1155 YHG=1119>other" XBD=365 XHG=86 YBD=1217 YHG=1171>departments " XBD=441 XHG=395 YBD=1205 YHG=1170>of " XBD=675 XHG=466 YBD=1211 YHG=1170>medicine, " XBD=789 XHG=707 YBD=1205 YHG=1170>and " XBD=962 XHG=817 YBD=1204 YHG=1169>indeed " XBD=1036 XHG=991 YBD=1204 YHG=1172>to " XBD=1205 XHG=1067 YBD=1204 YHG=1169>bodies " XBD=1281 XHG=1236 YBD=1203 YHG=1167>of" XBD=209 XHG=83 YBD=1266 YHG=1231>many " XBD=325 XHG=222 YBD=1255 YHG=1222>sorts " XBD=557 XHG=337 YBD=1255 YHG=1219>interested " XBD=613 XHG=569 YBD=1254 YHG=1219>in " XBD=695 XHG=624 YBD=1254 YHG=1218>the " XBD=963 XHG=707 YBD=1254 YHG=1217>furtherance " XBD=1022 XHG=977 YBD=1253 YHG=1218>of " XBD=1184 XHG=1032 YBD=1253 YHG=1218>science " XBD=1278 XHG=1198 YBD=1253 YHG=1218>and" XBD=1181 XHG=84 YBD=1318 YHG=1269>learning.

HAZARDS IN THE TREATMENT OFVARICOSE VEINS

" XBD=380 XHG=136 YBD=1538 YHG=1504>RESECTION " XBD=445 XHG=399 YBD=1538 YHG=1502>of " XBD=529 XHG=460 YBD=1538 YHG=1503>the " XBD=746 XHG=547 YBD=1549 YHG=1503>proximal " XBD=845 XHG=764 YBD=1539 YHG=1507>two " XBD=998 XHG=862 YBD=1538 YHG=1503>inches " XBD=1062 XHG=1017 YBD=1539 YHG=1503>of " XBD=1145 XHG=1075 YBD=1538 YHG=1503>the " XBD=1276 XHG=1162 YBD=1549 YHG=1506>great" XBD=311 XHG=86 YBD=1598 YHG=1552>saphenous " XBD=432 XHG=326 YBD=1594 YHG=1552>vein, " XBD=547 XHG=449 YBD=1587 YHG=1552>with " XBD=796 XHG=563 YBD=1588 YHG=1553>immediate " XBD=1003 XHG=810 YBD=1598 YHG=1553>injection " XBD=1064 XHG=1019 YBD=1588 YHG=1552>of " XBD=1099 XHG=1075 YBD=1588 YHG=1565>a " XBD=1274 XHG=1115 YBD=1588 YHG=1552>scleros-" XBD=153 XHG=84 YBD=1647 YHG=1602>ing " XBD=356 XHG=169 YBD=1644 YHG=1601>solution, " XBD=407 XHG=373 YBD=1636 YHG=1602>is " XBD=448 XHG=424 YBD=1636 YHG=1613>a " XBD=813 XHG=464 YBD=1637 YHG=1601>well-established " XBD=1049 XHG=828 YBD=1637 YHG=1605>treatment " XBD=1125 XHG=1064 YBD=1637 YHG=1602>for " XBD=1276 XHG=1141 YBD=1637 YHG=1613>severe" XBD=264 XHG=86 YBD=1685 YHG=1651>varicose " XBD=406 XHG=281 YBD=1685 YHG=1651>veins. " XBD=544 XHG=460 YBD=1685 YHG=1651>The " XBD=770 XHG=561 YBD=1696 YHG=1651>operation " XBD=821 XHG=787 YBD=1686 YHG=1652>is " XBD=1087 XHG=836 YBD=1686 YHG=1651>undertaken " XBD=1276 XHG=1104 YBD=1686 YHG=1651>without" XBD=208 XHG=87 YBD=1734 YHG=1700>much " XBD=317 XHG=232 YBD=1734 YHG=1699>fear " XBD=403 XHG=340 YBD=1734 YHG=1699>for " XBD=495 XHG=426 YBD=1734 YHG=1700>life " XBD=564 XHG=520 YBD=1735 YHG=1711>or " XBD=700 XHG=588 YBD=1735 YHG=1699>limb. " XBD=869 XHG=753 YBD=1742 YHG=1701>True, " XBD=965 XHG=887 YBD=1735 YHG=1700>the " XBD=1156 XHG=989 YBD=1735 YHG=1700>femoral " XBD=1273 XHG=1179 YBD=1735 YHG=1701>vein" XBD=122 XHG=88 YBD=1783 YHG=1749>is " XBD=252 XHG=150 YBD=1783 YHG=1748>close " XBD=324 XHG=279 YBD=1784 YHG=1752>to " XBD=421 XHG=350 YBD=1783 YHG=1749>the " XBD=524 XHG=449 YBD=1783 YHG=1750>site " XBD=598 XHG=552 YBD=1784 YHG=1748>of " XBD=830 XHG=621 YBD=1795 YHG=1750>operation " XBD=938 XHG=857 YBD=1785 YHG=1750>and " XBD=1017 XHG=963 YBD=1795 YHG=1750>its " XBD=1212 XHG=1044 YBD=1795 YHG=1750>damage " XBD=1273 XHG=1239 YBD=1784 YHG=1751>is" XBD=237 XHG=89 YBD=1843 YHG=1797>always " XBD=609 XHG=273 YBD=1844 YHG=1798>possible-cases " XBD=749 XHG=644 YBD=1833 YHG=1798>have " XBD=887 XHG=786 YBD=1834 YHG=1799>been " XBD=1108 XHG=921 YBD=1845 YHG=1799>reported " XBD=1190 XHG=1145 YBD=1834 YHG=1798>of " XBD=1275 XHG=1221 YBD=1834 YHG=1799>its" XBD=289 XHG=88 YBD=1882 YHG=1847>mistaken " XBD=620 XHG=321 YBD=1892 YHG=1846>ligature-but " XBD=822 XHG=654 YBD=1894 YHG=1859>average " XBD=947 XHG=857 YBD=1883 YHG=1848>skill " XBD=1123 XHG=980 YBD=1883 YHG=1848>should " XBD=1278 XHG=1157 YBD=1883 YHG=1848>avoid" XBD=187 XHG=90 YBD=1931 YHG=1896>such " XBD=445 XHG=215 YBD=1931 YHG=1895>calamities. " XBD=663 XHG=498 YBD=1931 YHG=1897>ATLAS however " XBD=1098 XHG=902 YBD=1932 YHG=1898>describes " XBD=1277 XHG=1125 YBD=1932 YHG=1896>several" XBD=300 XHG=88 YBD=1980 YHG=1945>untoward " XBD=538 XHG=327 YBD=1988 YHG=1945>incidents, " XBD=641 XHG=567 YBD=1981 YHG=1949>not " XBD=747 XHG=669 YBD=1981 YHG=1947>due " XBD=819 XHG=775 YBD=1982 YHG=1949>to " XBD=1116 XHG=848 YBD=1989 YHG=1947>carelessness, " XBD=1275 XHG=1144 YBD=1981 YHG=1946>which" XBD=240 XHG=85 YBD=2040 YHG=1994>though " XBD=499 XHG=256 YBD=2031 YHG=2006>uncommon " XBD=612 XHG=515 YBD=2040 YHG=2007>may " XBD=731 XHG=626 YBD=2030 YHG=1995>have " XBD=845 XHG=748 YBD=2030 YHG=1996>such " XBD=1010 XHG=862 YBD=2031 YHG=1997>serious " XBD=1170 XHG=1025 YBD=2031 YHG=1995>results " XBD=1279 XHG=1186 YBD=2030 YHG=1995>that" XBD=276 XHG=88 YBD=2089 YHG=2055>surgeons " XBD=439 XHG=296 YBD=2079 YHG=2043>should " XBD=508 XHG=458 YBD=2079 YHG=2044>be " XBD=581 XHG=528 YBD=2079 YHG=2056>on " XBD=705 XHG=599 YBD=2079 YHG=2044>their " XBD=849 XHG=722 YBD=2090 YHG=2045>guard " XBD=1026 XHG=869 YBD=2090 YHG=2045>against " XBD=1169 XHG=1044 YBD=2080 YHG=2045>them. " XBD=1274 XHG=1223 YBD=2079 YHG=2045>In" XBD=113 XHG=90 YBD=2128 YHG=2094>5 " XBD=244 XHG=136 YBD=2128 YHG=2104>cases " XBD=507 XHG=264 YBD=2128 YHG=2093>thrombosis " XBD=673 XHG=528 YBD=2139 YHG=2093>spread " XBD=780 XHG=693 YBD=2128 YHG=2093>into " XBD=871 XHG=800 YBD=2128 YHG=2094>the " XBD=991 XHG=892 YBD=2140 YHG=2095>deep " XBD=1124 XHG=1011 YBD=2129 YHG=2095>veins " XBD=1191 XHG=1145 YBD=2129 YHG=2094>of " XBD=1278 XHG=1206 YBD=2129 YHG=2094>the" XBD=219 XHG=90 YBD=2188 YHG=2142>thigh, " XBD=456 XHG=234 YBD=2188 YHG=2142>producing " XBD=524 XHG=470 YBD=2176 YHG=2154>an " XBD=719 XHG=538 YBD=2177 YHG=2142>embolus " XBD=776 XHG=733 YBD=2177 YHG=2143>in " XBD=814 XHG=792 YBD=2178 YHG=2144>3 " XBD=952 XHG=831 YBD=2185 YHG=2154>cases, " XBD=1065 XHG=968 YBD=2178 YHG=2143>with " XBD=1104 XHG=1081 YBD=2177 YHG=2144>2 " XBD=1277 XHG=1120 YBD=2178 YHG=2143>deaths." XBD=229 XHG=91 YBD=2227 YHG=2191>ATLAS believes " XBD=560 XHG=466 YBD=2226 YHG=2191>that " XBD=663 XHG=592 YBD=2226 YHG=2191>the " XBD=924 XHG=694 YBD=2237 YHG=2192>retrograde " XBD=1148 XHG=955 YBD=2237 YHG=2192>injection " XBD=1226 XHG=1181 YBD=2227 YHG=2192>of " XBD=1279 XHG=1254 YBD=2226 YHG=2203>a" XBD=304 XHG=93 YBD=2286 YHG=2240>sclerosing " XBD=509 XHG=334 YBD=2276 YHG=2240>solution " XBD=584 XHG=539 YBD=2275 YHG=2243>at " XBD=684 XHG=613 YBD=2276 YHG=2240>the " XBD=812 XHG=713 YBD=2275 YHG=2240>time " XBD=888 XHG=842 YBD=2275 YHG=2240>of " XBD=1108 XHG=912 YBD=2276 YHG=2241>resection " XBD=1182 XHG=1137 YBD=2276 YHG=2240>of " XBD=1278 XHG=1207 YBD=2275 YHG=2241>the" XBD=317 XHG=92 YBD=2337 YHG=2290>saphenous " XBD=442 XHG=348 YBD=2326 YHG=2290>vein " XBD=617 XHG=473 YBD=2328 YHG=2289>should " XBD=699 XHG=646 YBD=2325 YHG=2290>be " XBD=951 XHG=730 YBD=2326 YHG=2290>discarded. " XBD=1055 XHG=1004 YBD=2325 YHG=2290>In " XBD=1146 XHG=1084 YBD=2325 YHG=2290>his " XBD=1279 XHG=1177 YBD=2325 YHG=2290>view" XBD=283 XHG=90 YBD=2386 YHG=2340>injection " XBD=451 XHG=307 YBD=2375 YHG=2339>should " XBD=526 XHG=476 YBD=2375 YHG=2340>be " XBD=648 XHG=543 YBD=2375 YHG=2340>done " XBD=709 XHG=666 YBD=2374 YHG=2339>in " XBD=937 XHG=726 YBD=2375 YHG=2338>ambulant " XBD=1133 XHG=955 YBD=2385 YHG=2340>patients " XBD=1278 XHG=1157 YBD=2385 YHG=2339>only ;" XBD=193 XHG=92 YBD=2427 YHG=2401>even " XBD=281 XHG=211 YBD=2424 YHG=2389>the " XBD=412 XHG=301 YBD=2424 YHG=2389>short " XBD=694 XHG=426 YBD=2433 YHG=2389>recumbency " XBD=859 XHG=706 YBD=2423 YHG=2388>needed " XBD=982 XHG=878 YBD=2425 YHG=2388>after " XBD=1070 XHG=1000 YBD=2423 YHG=2388>the " XBD=1279 XHG=1083 YBD=2423 YHG=2388>resection" XBD=301 XHG=92 YBD=2484 YHG=2439>operation " XBD=433 XHG=336 YBD=2484 YHG=2450>may " XBD=690 XHG=468 YBD=2473 YHG=2437>determine " XBD=967 XHG=725 YBD=2472 YHG=2437>thrombosis " XBD=1046 XHG=1003 YBD=2471 YHG=2437>in " XBD=1152 XHG=1081 YBD=2472 YHG=2437>the " XBD=1279 XHG=1188 YBD=2472 YHG=2438>ileo-" XBD=259 XHG=92 YBD=2523 YHG=2487>femoral " XBD=386 XHG=281 YBD=2522 YHG=2488>vein. " XBD=642 XHG=440 YBD=2531 YHG=2487>Injection " XBD=838 XHG=663 YBD=2531 YHG=2486>through " XBD=886 XHG=862 YBD=2520 YHG=2498>a " XBD=1076 XHG=908 YBD=2520 YHG=2487>ureteric " XBD=1312 XHG=1100 YBD=2521 YHG=2486>catheter" XBD=236 XHG=91 YBD=2582 YHG=2536>passed " XBD=375 XHG=257 YBD=2571 YHG=2537>down " XBD=467 XHG=395 YBD=2571 YHG=2536>the " XBD=610 XHG=488 YBD=2571 YHG=2535>distal " XBD=793 XHG=631 YBD=2581 YHG=2535>portion " XBD=859 XHG=814 YBD=2570 YHG=2534>of " XBD=949 XHG=879 YBD=2569 YHG=2535>the " XBD=1063 XHG=970 YBD=2569 YHG=2535>vein " XBD=1157 XHG=1083 YBD=2569 YHG=2535>has " XBD=1280 XHG=1178 YBD=2570 YHG=2536>been" XBD=317 XHG=94 YBD=2630 YHG=2585>suggested, " XBD=411 XHG=335 YBD=2620 YHG=2585>but " XBD=624 XHG=427 YBD=2620 YHG=2585>branches " XBD=687 XHG=641 YBD=2620 YHG=2584>of " XBD=777 XHG=706 YBD=2619 YHG=2584>the " XBD=1019 XHG=794 YBD=2629 YHG=2583>saphenous " XBD=1129 XHG=1036 YBD=2618 YHG=2584>vein " XBD=1280 XHG=1153 YBD=2618 YHG=2584>below" XBD=164 XHG=93 YBD=2669 YHG=2634>the " XBD=290 XHG=187 YBD=2668 YHG=2634>knee " XBD=409 XHG=313 YBD=2679 YHG=2645>may " XBD=728 XHG=436 YBD=2668 YHG=2633>communicate " XBD=851 XHG=752 YBD=2668 YHG=2633>with " XBD=946 XHG=876 YBD=2676 YHG=2632>the " XBD=1162 XHG=970 YBD=2678 YHG=2632>popliteal " XBD=1280 XHG=1186 YBD=2667 YHG=2632>vein" XBD=138 XHG=94 YBD=2718 YHG=2695>so " XBD=247 XHG=154 YBD=2717 YHG=2682>that " XBD=368 XHG=262 YBD=2717 YHG=2682>little " XBD=418 XHG=384 YBD=2717 YHG=2683>is " XBD=591 XHG=435 YBD=2728 YHG=2683>gained. " XBD=772 XHG=645 YBD=2717 YHG=2683>There " XBD=821 XHG=788 YBD=2716 YHG=2682>is " XBD=908 XHG=838 YBD=2716 YHG=2681>the " XBD=1057 XHG=925 YBD=2716 YHG=2681>added " XBD=1222 XHG=1073 YBD=2727 YHG=2681>danger " XBD=1284 XHG=1239 YBD=2716 YHG=2681>of" XBD=228 XHG=92 YBD=2777 YHG=2731>injury " XBD=285 XHG=240 YBD=2766 YHG=2734>to " XBD=367 XHG=297 YBD=2766 YHG=2731>the " XBD=471 XHG=380 YBD=2766 YHG=2731>wall " XBD=528 XHG=483 YBD=2766 YHG=2731>of " XBD=607 XHG=536 YBD=2766 YHG=2731>the " XBD=713 XHG=620 YBD=2766 YHG=2732>vein " XBD=782 XHG=726 YBD=2777 YHG=2731>by " XBD=864 XHG=794 YBD=2765 YHG=2731>the " XBD=937 XHG=877 YBD=2776 YHG=2731>tip " XBD=996 XHG=951 YBD=2765 YHG=2729>of " XBD=1074 XHG=1004 YBD=2765 YHG=2730>the " XBD=1280 XHG=1088 YBD=2772 YHG=2730>catheter," XBD=192 XHG=93 YBD=2815 YHG=2780>with " XBD=394 XHG=230 YBD=2826 YHG=2780>leakage " XBD=479 XHG=433 YBD=2815 YHG=2780>of " XBD=584 XHG=513 YBD=2814 YHG=2780>the " XBD=835 XHG=623 YBD=2825 YHG=2780>sclerosing " XBD=1049 XHG=874 YBD=2814 YHG=2779>solution " XBD=1173 XHG=1085 YBD=2814 YHG=2780>into " XBD=1282 XHG=1211 YBD=2814 YHG=2779>the" XBD=332 XHG=94 YBD=2875 YHG=2829>perivenous " XBD=524 XHG=367 YBD=2863 YHG=2829>tissues. " XBD=629 XHG=579 YBD=2863 YHG=2830>In " XBD=734 XHG=664 YBD=2864 YHG=2829>the " XBD=981 XHG=770 YBD=2863 YHG=2828>ambulant " XBD=1173 XHG=1015 YBD=2873 YHG=2828>patient " XBD=1279 XHG=1208 YBD=2862 YHG=2828>the" XBD=246 XHG=85 YBD=2930 YHG=2888>venous " XBD=346 XHG=261 YBD=2911 YHG=2880>tree " XBD=394 XHG=361 YBD=2911 YHG=2877>is " XBD=569 XHG=409 YBD=2922 YHG=2877>usually " XBD=672 XHG=584 YBD=2912 YHG=2877>well " XBD=803 XHG=687 YBD=2922 YHG=2889>open, " XBD=901 XHG=820 YBD=2911 YHG=2878>and " XBD=985 XHG=915 YBD=2912 YHG=2877>the " XBD=1090 XHG=999 YBD=2911 YHG=2876>flow " XBD=1150 XHG=1106 YBD=2910 YHG=2875>of " XBD=1283 XHG=1162 YBD=2911 YHG=2876>blood" XBD=227 XHG=95 YBD=2967 YHG=2925>swift ; " XBD=343 XHG=262 YBD=2960 YHG=2925>this " XBD=395 XHG=362 YBD=2959 YHG=2925>is " XBD=467 XHG=415 YBD=2959 YHG=2937>an " XBD=696 XHG=485 YBD=2960 YHG=2926>insurance " XBD=872 XHG=715 YBD=2971 YHG=2927>against " XBD=1145 XHG=891 YBD=2960 YHG=2925>thrombosis. " XBD=1281 XHG=1198 YBD=2960 YHG=2925>Un-" XBD=346 XHG=96 YBD=3019 YHG=2973>fortunately " XBD=400 XHG=367 YBD=3008 YHG=2974>it " XBD=455 XHG=421 YBD=3008 YHG=2973>is " XBD=542 XHG=469 YBD=3008 YHG=2977>not " XBD=588 XHG=564 YBD=3008 YHG=2986>a " XBD=807 XHG=611 YBD=3019 YHG=2974>complete " XBD=1049 XHG=828 YBD=3016 YHG=2975>insurance, " XBD=1127 XHG=1065 YBD=3009 YHG=2974>for " XBD=1282 XHG=1144 YBD=3008 YHG=2974>ALTAS

reports " XBD=291 XHG=267 YBD=3057 YHG=3034>a " XBD=397 XHG=309 YBD=3057 YHG=3033>case " XBD=456 XHG=413 YBD=3056 YHG=3022>in " XBD=601 XHG=471 YBD=3056 YHG=3022>which " XBD=811 XHG=618 YBD=3068 YHG=3023>popliteal " XBD=1069 XHG=827 YBD=3058 YHG=3023>thrombosis " XBD=1167 XHG=1085 YBD=3057 YHG=3023>and " XBD=1279 XHG=1182 YBD=3057 YHG=3033>non-" XBD=196 XHG=94 YBD=3106 YHG=3071>fatal " XBD=481 XHG=239 YBD=3116 YHG=3070>pulmonary " XBD=734 XHG=525 YBD=3106 YHG=3071>embolism " XBD=961 XHG=778 YBD=3106 YHG=3071>followed " XBD=1197 XHG=1004 YBD=3116 YHG=3071>injection " XBD=1287 XHG=1241 YBD=3105 YHG=3069>of

0-5 " XBD=293 XHG=181 YBD=3154 YHG=3131>c.cm. " XBD=361 XHG=316 YBD=3153 YHG=3119>of " XBD=451 XHG=379 YBD=3163 YHG=3118>5% " XBD=632 XHG=475 YBD=3152 YHG=3119>sodium " XBD=884 XHG=653 YBD=3154 YHG=3119>morrhuate " XBD=988 XHG=903 YBD=3154 YHG=3120>into " XBD=1034 XHG=1011 YBD=3153 YHG=3131>a " XBD=1281 XHG=1060 YBD=3154 YHG=3119>moderate-" XBD=200 XHG=93 YBD=3202 YHG=3168>sized " XBD=346 XHG=230 YBD=3201 YHG=3168>varix " XBD=430 XHG=378 YBD=3201 YHG=3179>on " XBD=532 XHG=462 YBD=3201 YHG=3166>the " XBD=711 XHG=563 YBD=3201 YHG=3166>medial " XBD=880 XHG=742 YBD=3212 YHG=3170>aspect " XBD=956 XHG=911 YBD=3202 YHG=3168>of " XBD=1053 XHG=983 YBD=3202 YHG=3168>the " XBD=1157 XHG=1083 YBD=3201 YHG=3167>left " XBD=1280 XHG=1190 YBD=3201 YHG=3166>calf." XBD=276 XHG=92 YBD=3250 YHG=3215>Division " XBD=339 XHG=294 YBD=3249 YHG=3215>of " XBD=423 XHG=352 YBD=3249 YHG=3215>the " XBD=608 XHG=440 YBD=3249 YHG=3214>femoral " XBD=718 XHG=625 YBD=3249 YHG=3215>vein " XBD=916 XHG=736 YBD=3250 YHG=3215>between " XBD=1134 XHG=932 YBD=3260 YHG=3215>ligatures, " XBD=1281 XHG=1154 YBD=3249 YHG=3215>under" XBD=194 XHG=85 YBD=3297 YHG=3263>local " XBD=482 XHG=232 YBD=3304 YHG=3264>anaesthesia, " XBD=589 XHG=523 YBD=3297 YHG=3263>led " XBD=672 XHG=628 YBD=3297 YHG=3266>to " XBD=765 XHG=712 YBD=3297 YHG=3274>an " XBD=1040 XHG=804 YBD=3298 YHG=3263>uneventful " XBD=1280 XHG=1078 YBD=3308 YHG=3274>recovery." XBD=315 XHG=81 YBD=3345 YHG=3311>Disturbed " XBD=402 XHG=346 YBD=3356 YHG=3312>by " XBD=514 XHG=432 YBD=3345 YHG=3312>this " XBD=648 XHG=546 YBD=3352 YHG=3323>case, " XBD=761 XHG=681 YBD=3345 YHG=3311>and " XBD=847 XHG=792 YBD=3356 YHG=3311>by " XBD=1032 XHG=877 YBD=3356 YHG=3315>reports " XBD=1107 XHG=1063 YBD=3346 YHG=3312>of " XBD=1285 XHG=1135 YBD=3346 YHG=3312>similar" XBD=329 XHG=98 YBD=3400 YHG=3357>calamities, " XBD=490 XHG=352 YBD=3393 YHG=3360>ATLAS " XBD=587 XHG=513 YBD=3393 YHG=3360>has " XBD=877 XHG=607 YBD=3404 YHG=3359>investigated " XBD=967 XHG=898 YBD=3394 YHG=3359>the " XBD=1073 XHG=988 YBD=3394 YHG=3359>fate " XBD=1139 XHG=1094 YBD=3394 YHG=3360>of " XBD=1284 XHG=1156 YBD=3395 YHG=3361>radio-

1. Atlas, L. N. Surg. Gynec. Obstet. 1943, 77, 136.

" XBD=1495 XHG=1337 YBD=238 YHG=203>opaque " XBD=1711 XHG=1517 YBD=227 YHG=192>solutions " XBD=1906 XHG=1731 YBD=235 YHG=192>injected " XBD=2012 XHG=1926 YBD=226 YHG=192>into " XBD=2102 XHG=2033 YBD=226 YHG=191>the " XBD=2279 XHG=2124 YBD=226 YHG=191>normal " XBD=2521 XHG=2300 YBD=236 YHG=191>saphenous" XBD=1442 XHG=1336 YBD=275 YHG=241>vein. " XBD=1581 XHG=1497 YBD=275 YHG=241>The " XBD=1782 XHG=1607 YBD=275 YHG=240>solution " XBD=1971 XHG=1812 YBD=285 YHG=239>rapidly " XBD=2121 XHG=1995 YBD=275 YHG=239>found " XBD=2205 XHG=2152 YBD=274 YHG=240>its " XBD=2321 XHG=2230 YBD=284 YHG=250>way " XBD=2522 XHG=2350 YBD=285 YHG=239>through" XBD=1613 XHG=1337 YBD=324 YHG=293>anastomoses " XBD=1838 XHG=1658 YBD=324 YHG=289>between " XBD=1951 XHG=1882 YBD=323 YHG=289>the " XBD=2118 XHG=2000 YBD=323 YHG=288>lesser " XBD=2244 XHG=2163 YBD=323 YHG=289>and " XBD=2366 XHG=2296 YBD=323 YHG=288>the " XBD=2520 XHG=2410 YBD=333 YHG=291>great" XBD=1565 XHG=1338 YBD=384 YHG=338>saphenous " XBD=1733 XHG=1609 YBD=372 YHG=338>veins. " XBD=1907 XHG=1799 YBD=372 YHG=337>Once " XBD=1991 XHG=1948 YBD=371 YHG=338>in " XBD=2099 XHG=2029 YBD=372 YHG=337>the " XBD=2258 XHG=2139 YBD=371 YHG=337>lesser " XBD=2522 XHG=2301 YBD=382 YHG=337>saphenous" XBD=1443 XHG=1337 YBD=428 YHG=386>vein, " XBD=1545 XHG=1474 YBD=421 YHG=386>the " XBD=1742 XHG=1576 YBD=432 YHG=397>passage " XBD=1818 XHG=1773 YBD=420 YHG=389>to " XBD=1919 XHG=1849 YBD=420 YHG=386>the " XBD=2143 XHG=1951 YBD=431 YHG=385>popliteal " XBD=2267 XHG=2174 YBD=420 YHG=385>vein " XBD=2376 XHG=2296 YBD=420 YHG=396>was " XBD=2522 XHG=2406 YBD=430 YHG=384>quick" XBD=1419 XHG=1337 YBD=469 YHG=435>and " XBD=1545 XHG=1438 YBD=479 YHG=446>easy." XBD=1473 XHG=1388 YBD=522 YHG=488>The " XBD=1745 XHG=1495 YBD=533 YHG=489>importance " XBD=1813 XHG=1769 YBD=522 YHG=488>of " XBD=1903 XHG=1832 YBD=522 YHG=488>the " XBD=2026 XHG=1926 YBD=532 YHG=488>deep " XBD=2389 XHG=2052 YBD=532 YHG=487>communicating " XBD=2522 XHG=2412 YBD=522 YHG=487>veins" XBD=1412 XHG=1338 YBD=570 YHG=536>has " XBD=1547 XHG=1445 YBD=570 YHG=536>been " XBD=1714 XHG=1577 YBD=570 YHG=536>rather " XBD=1996 XHG=1746 YBD=570 YHG=535>overlooked. HELLER " XBD=2422 XHG=2240 YBD=581 YHG=536>2 points " XBD=2523 XHG=2453 YBD=570 YHG=539>out" XBD=1431 XHG=1338 YBD=619 YHG=584>that " XBD=1556 XHG=1448 YBD=619 YHG=587>most " XBD=1619 XHG=1573 YBD=618 YHG=583>of " XBD=1700 XHG=1630 YBD=618 YHG=584>the " XBD=1837 XHG=1718 YBD=618 YHG=583>blood " XBD=1897 XHG=1853 YBD=618 YHG=583>in " XBD=1982 XHG=1912 YBD=618 YHG=584>the " XBD=2222 XHG=2000 YBD=629 YHG=584>superficial " XBD=2351 XHG=2238 YBD=618 YHG=585>veins " XBD=2522 XHG=2367 YBD=618 YHG=586>returns" XBD=1382 XHG=1338 YBD=667 YHG=635>to " XBD=1486 XHG=1416 YBD=666 YHG=632>the " XBD=1636 XHG=1519 YBD=666 YHG=632>heart " XBD=1735 XHG=1668 YBD=666 YHG=632>via " XBD=1879 XHG=1767 YBD=667 YHG=632>these " XBD=2250 XHG=1914 YBD=677 YHG=633>communicating " XBD=2407 XHG=2283 YBD=667 YHG=632>veins. " XBD=2522 XHG=2460 YBD=667 YHG=633>He" XBD=1500 XHG=1338 YBD=726 YHG=680>regards " XBD=1600 XHG=1529 YBD=715 YHG=681>the " XBD=1756 XHG=1629 YBD=726 YHG=691>upper " XBD=1862 XHG=1784 YBD=716 YHG=681>end " XBD=1936 XHG=1892 YBD=715 YHG=680>of " XBD=2030 XHG=1960 YBD=716 YHG=681>the " XBD=2151 XHG=2058 YBD=727 YHG=680>long " XBD=2405 XHG=2180 YBD=727 YHG=681>saphenous " XBD=2522 XHG=2433 YBD=716 YHG=681>vein" XBD=1491 XHG=1339 YBD=775 YHG=729>merely " XBD=1559 XHG=1514 YBD=764 YHG=741>as " XBD=1636 XHG=1583 YBD=764 YHG=741>an " XBD=1845 XHG=1660 YBD=765 YHG=730>overflow " XBD=1973 XHG=1868 YBD=775 YHG=730>pipe, " XBD=2079 XHG=1999 YBD=765 YHG=730>and " XBD=2231 XHG=2103 YBD=765 YHG=731>draws " XBD=2458 XHG=2255 YBD=765 YHG=729>attention " XBD=2521 XHG=2479 YBD=765 YHG=733>to" XBD=1411 XHG=1339 YBD=812 YHG=778>the " XBD=1614 XHG=1429 YBD=813 YHG=790>common " XBD=1781 XHG=1630 YBD=823 YHG=778>finding " XBD=1841 XHG=1797 YBD=813 YHG=782>at " XBD=2075 XHG=1866 YBD=824 YHG=779>operation " XBD=2182 XHG=2089 YBD=813 YHG=779>that " XBD=2277 XHG=2206 YBD=813 YHG=780>the " XBD=2520 XHG=2299 YBD=823 YHG=779>saphenous" XBD=1434 XHG=1340 YBD=861 YHG=827>vein " XBD=1493 XHG=1449 YBD=861 YHG=829>at " XBD=1580 XHG=1509 YBD=861 YHG=827>the " XBD=1701 XHG=1595 YBD=862 YHG=826>fossa " XBD=1843 XHG=1718 YBD=862 YHG=827>ovalis " XBD=1891 XHG=1858 YBD=861 YHG=827>is " XBD=2167 XHG=1908 YBD=873 YHG=827>surprisingly " XBD=2298 XHG=2182 YBD=862 YHG=827>small " XBD=2522 XHG=2314 YBD=872 YHG=827>compared" XBD=1383 XHG=1338 YBD=910 YHG=878>to " XBD=1474 XHG=1404 YBD=910 YHG=875>the " XBD=1610 XHG=1496 YBD=910 YHG=875>veins " XBD=1673 XHG=1630 YBD=910 YHG=876>in " XBD=1763 XHG=1693 YBD=910 YHG=876>the " XBD=1902 XHG=1783 YBD=910 YHG=875>lower " XBD=1995 XHG=1921 YBD=921 YHG=875>leg. " XBD=2113 XHG=2050 YBD=911 YHG=876>On " XBD=2333 XHG=2133 YBD=910 YHG=876>muscular " XBD=2522 XHG=2353 YBD=920 YHG=875>activity" XBD=1409 XHG=1338 YBD=958 YHG=923>the " XBD=1680 XHG=1429 YBD=970 YHG=925>contracting " XBD=1781 XHG=1700 YBD=959 YHG=923>calf " XBD=1965 XHG=1795 YBD=958 YHG=923>muscles " XBD=2148 XHG=1983 YBD=969 YHG=935>squeeze " XBD=2236 XHG=2166 YBD=959 YHG=924>the " XBD=2376 XHG=2255 YBD=959 YHG=924>blood " XBD=2466 XHG=2395 YBD=959 YHG=927>out " XBD=2526 XHG=2484 YBD=960 YHG=924>of" XBD=1412 XHG=1338 YBD=1007 YHG=972>the " XBD=1534 XHG=1432 YBD=1018 YHG=973>deep " XBD=1670 XHG=1557 YBD=1008 YHG=973>veins " XBD=1802 XHG=1692 YBD=1019 YHG=973>lying " XBD=1966 XHG=1824 YBD=1008 YHG=973>within " XBD=2058 XHG=1988 YBD=1008 YHG=973>the " XBD=2219 XHG=2080 YBD=1008 YHG=973>fascial " XBD=2417 XHG=2243 YBD=1008 YHG=972>sheaths. " XBD=2522 XHG=2468 YBD=1008 YHG=973>As" XBD=1411 XHG=1340 YBD=1056 YHG=1021>the " XBD=1603 XHG=1426 YBD=1057 YHG=1022>muscles " XBD=1732 XHG=1623 YBD=1057 YHG=1023>relax " XBD=1875 XHG=1754 YBD=1057 YHG=1022>blood " XBD=1928 XHG=1896 YBD=1056 YHG=1022>is " XBD=2098 XHG=1950 YBD=1056 YHG=1022>sucked " XBD=2222 XHG=2119 YBD=1056 YHG=1022>from " XBD=2314 XHG=2243 YBD=1056 YHG=1022>the " XBD=2522 XHG=2336 YBD=1067 YHG=1021>capillary" XBD=1428 XHG=1338 YBD=1111 YHG=1069>bed, " XBD=1525 XHG=1443 YBD=1105 YHG=1071>and " XBD=1622 XHG=1538 YBD=1105 YHG=1070>also " XBD=1691 XHG=1636 YBD=1115 YHG=1071>by " XBD=1838 XHG=1701 YBD=1105 YHG=1082>means " XBD=1897 XHG=1852 YBD=1105 YHG=1070>of " XBD=1975 XHG=1905 YBD=1104 YHG=1070>the " XBD=2326 XHG=1989 YBD=1115 YHG=1071>communicating " XBD=2522 XHG=2339 YBD=1105 YHG=1070>channels" XBD=1441 XHG=1336 YBD=1153 YHG=1118>from " XBD=1530 XHG=1459 YBD=1153 YHG=1119>the " XBD=1771 XHG=1549 YBD=1165 YHG=1119>superficial " XBD=1913 XHG=1788 YBD=1154 YHG=1119>veins. " XBD=2143 XHG=1965 YBD=1154 YHG=1120>HELLER " XBD=2232 XHG=2159 YBD=1153 YHG=1119>has " XBD=2425 XHG=2252 YBD=1153 YHG=1118>checked " XBD=2520 XHG=2442 YBD=1154 YHG=1118>this" XBD=1396 XHG=1340 YBD=1213 YHG=1168>by " XBD=1700 XHG=1448 YBD=1203 YHG=1168>estimations " XBD=1798 XHG=1753 YBD=1203 YHG=1168>of " XBD=2125 XHG=1845 YBD=1214 YHG=1168>leg-to-throat " XBD=2521 XHG=2177 YBD=1204 YHG=1167>circulation-time" XBD=1422 XHG=1340 YBD=1252 YHG=1217>and " XBD=1500 XHG=1445 YBD=1262 YHG=1217>by " XBD=1798 XHG=1521 YBD=1262 YHG=1217>radiographic " XBD=1971 XHG=1820 YBD=1252 YHG=1217>studies " XBD=2089 XHG=1993 YBD=1252 YHG=1217>with " XBD=2136 XHG=2112 YBD=1251 YHG=1229>a " XBD=2333 XHG=2158 YBD=1252 YHG=1216>solution " XBD=2399 XHG=2354 YBD=1251 YHG=1216>of " XBD=2520 XHG=2416 YBD=1252 YHG=1217>iodo-" XBD=1526 XHG=1340 YBD=1312 YHG=1266>hippuric " XBD=1636 XHG=1546 YBD=1301 YHG=1266>acid " XBD=1803 XHG=1654 YBD=1311 YHG=1266>having " XBD=1892 XHG=1822 YBD=1301 YHG=1267>the " XBD=2019 XHG=1912 YBD=1302 YHG=1278>same " XBD=2195 XHG=2039 YBD=1312 YHG=1265>specific " XBD=2375 XHG=2213 YBD=1311 YHG=1266>gravity " XBD=2437 XHG=2393 YBD=1301 YHG=1278>as " XBD=2521 XHG=2454 YBD=1301 YHG=1266>the" XBD=1473 XHG=1341 YBD=1350 YHG=1315>blood. " XBD=1592 XHG=1528 YBD=1350 YHG=1316>He " XBD=1742 XHG=1607 YBD=1360 YHG=1315>points " XBD=1828 XHG=1757 YBD=1349 YHG=1318>out " XBD=1935 XHG=1843 YBD=1349 YHG=1315>that " XBD=2064 XHG=1949 YBD=1350 YHG=1315>when " XBD=2102 XHG=2078 YBD=1349 YHG=1327>a " XBD=2275 XHG=2117 YBD=1360 YHG=1315>patient " XBD=2322 XHG=2289 YBD=1349 YHG=1314>is " XBD=2520 XHG=2337 YBD=1360 YHG=1315>standing" XBD=1498 XHG=1342 YBD=1409 YHG=1364>quietly " XBD=1592 XHG=1521 YBD=1398 YHG=1364>the " XBD=1839 XHG=1616 YBD=1409 YHG=1363>saphenous " XBD=1954 XHG=1861 YBD=1398 YHG=1364>vein " XBD=2072 XHG=1976 YBD=1409 YHG=1375>may " XBD=2189 XHG=2093 YBD=1398 YHG=1363>take " XBD=2262 XHG=2215 YBD=1398 YHG=1364>10 " XBD=2457 XHG=2285 YBD=1399 YHG=1364>minutes " XBD=2521 XHG=2480 YBD=1398 YHG=1375>or" XBD=1448 XHG=1338 YBD=1448 YHG=1424>more " XBD=1513 XHG=1468 YBD=1447 YHG=1416>to " XBD=1687 XHG=1534 YBD=1458 YHG=1416>empty. " XBD=1870 XHG=1740 YBD=1448 YHG=1413>When " XBD=1959 XHG=1889 YBD=1447 YHG=1413>the " XBD=2147 XHG=1978 YBD=1447 YHG=1411>muscles " XBD=2233 XHG=2166 YBD=1447 YHG=1423>are " XBD=2394 XHG=2252 YBD=1447 YHG=1412>flaccid " XBD=2520 XHG=2412 YBD=1447 YHG=1413>there" XBD=1435 XHG=1337 YBD=1507 YHG=1474>may " XBD=1553 XHG=1456 YBD=1496 YHG=1461>thus " XBD=1625 XHG=1576 YBD=1496 YHG=1462>be " XBD=1672 XHG=1648 YBD=1496 YHG=1474>a " XBD=1965 XHG=1696 YBD=1497 YHG=1461>considerable " XBD=2155 XHG=1987 YBD=1507 YHG=1461>hold-up " XBD=2224 XHG=2179 YBD=1496 YHG=1461>of " XBD=2311 XHG=2241 YBD=1497 YHG=1461>the " XBD=2520 XHG=2333 YBD=1506 YHG=1462>injection" XBD=1525 XHG=1338 YBD=1553 YHG=1511>solution, " XBD=1633 XHG=1552 YBD=1545 YHG=1511>and " XBD=1736 XHG=1655 YBD=1545 YHG=1511>this " XBD=1855 XHG=1759 YBD=1556 YHG=1522>may " XBD=2037 XHG=1878 YBD=1556 YHG=1510>explain " XBD=2130 XHG=2060 YBD=1545 YHG=1511>the " XBD=2305 XHG=2153 YBD=1545 YHG=1510>violent " XBD=2520 XHG=2328 YBD=1546 YHG=1510>reactions" XBD=1379 XHG=1337 YBD=1594 YHG=1560>in " XBD=1471 XHG=1400 YBD=1595 YHG=1561>the superncial " XBD=1849 XHG=1738 YBD=1594 YHG=1561>veins " XBD=1984 XHG=1872 YBD=1595 YHG=1559>often " XBD=2097 XHG=2006 YBD=1594 YHG=1571>seen " XBD=2233 XHG=2118 YBD=1595 YHG=1560>when " XBD=2422 XHG=2252 YBD=1605 YHG=1560>ligature " XBD=2519 XHG=2443 YBD=1595 YHG=1559>and" XBD=1531 XHG=1336 YBD=1655 YHG=1610>injection " XBD=1620 XHG=1553 YBD=1644 YHG=1620>are " XBD=1744 XHG=1641 YBD=1644 YHG=1610>done " XBD=1892 XHG=1765 YBD=1643 YHG=1609>under " XBD=2070 XHG=1913 YBD=1655 YHG=1609>general " XBD=2340 XHG=2091 YBD=1644 YHG=1609>anaesthesia. " XBD=2437 XHG=2395 YBD=1643 YHG=1608>If " XBD=2519 XHG=2452 YBD=1644 YHG=1609>the" XBD=1497 XHG=1337 YBD=1705 YHG=1659>patient " XBD=1566 XHG=1532 YBD=1693 YHG=1658>is " XBD=1656 XHG=1602 YBD=1704 YHG=1670>up " XBD=1773 XHG=1693 YBD=1693 YHG=1658>and " XBD=1934 XHG=1808 YBD=1693 YHG=1658>about " XBD=2038 XHG=1969 YBD=1693 YHG=1658>the " XBD=2248 XHG=2073 YBD=1703 YHG=1658>injected " XBD=2455 XHG=2284 YBD=1693 YHG=1658>solution " XBD=2519 XHG=2487 YBD=1692 YHG=1658>is" XBD=1497 XHG=1336 YBD=1753 YHG=1707>rapidly " XBD=1643 XHG=1517 YBD=1753 YHG=1711>swept " XBD=1779 XHG=1664 YBD=1753 YHG=1719>away " XBD=1878 XHG=1797 YBD=1742 YHG=1708>and " XBD=2052 XHG=1899 YBD=1742 YHG=1707>diluted " XBD=2114 XHG=2072 YBD=1742 YHG=1708>in " XBD=2203 XHG=2133 YBD=1742 YHG=1708>the " XBD=2517 XHG=2224 YBD=1749 YHG=1707>blood-stream," XBD=1381 XHG=1338 YBD=1792 YHG=1768>so " XBD=1507 XHG=1413 YBD=1792 YHG=1757>that " XBD=1592 XHG=1537 YBD=1791 YHG=1756>its " XBD=1757 XHG=1622 YBD=1791 YHG=1757>action " XBD=1820 XHG=1786 YBD=1790 YHG=1756>is " XBD=2099 XHG=1851 YBD=1792 YHG=1756>short-lived. " XBD=2354 XHG=2153 YBD=1802 YHG=1757>Injection " XBD=2428 XHG=2384 YBD=1791 YHG=1756>of " XBD=2519 XHG=2452 YBD=1791 YHG=1756>the" XBD=1514 XHG=1338 YBD=1841 YHG=1805>solution " XBD=1602 XHG=1558 YBD=1840 YHG=1809>at " XBD=1854 XHG=1646 YBD=1851 YHG=1806>operation " XBD=1981 XHG=1898 YBD=1840 YHG=1805>also " XBD=2254 XHG=2026 YBD=1851 YHG=1805>commonly " XBD=2439 XHG=2296 YBD=1840 YHG=1805>results " XBD=2544 XHG=2480 YBD=1851 YHG=1805>in" XBD=1497 XHG=1339 YBD=1901 YHG=1855>spilling " XBD=1574 XHG=1530 YBD=1889 YHG=1866>or " XBD=1768 XHG=1605 YBD=1900 YHG=1854>leakage " XBD=1898 XHG=1800 YBD=1890 YHG=1855>with " XBD=2173 XHG=1930 YBD=1901 YHG=1856>subsequent " XBD=2307 XHG=2205 YBD=1890 YHG=1855>local " XBD=2517 XHG=2339 YBD=1896 YHG=1855>necrosis," XBD=1552 XHG=1338 YBD=1949 YHG=1903>especially " XBD=1614 XHG=1571 YBD=1938 YHG=1904>in " XBD=1934 XHG=1632 YBD=1949 YHG=1904>inexperienced " XBD=2094 XHG=1953 YBD=1939 YHG=1904>hands. " XBD=2232 XHG=2149 YBD=1939 YHG=1904>The " XBD=2348 XHG=2252 YBD=1939 YHG=1904>slow " XBD=2518 XHG=2366 YBD=1949 YHG=1903>healing" XBD=1384 XHG=1338 YBD=1988 YHG=1953>of " XBD=1692 XHG=1403 YBD=1990 YHG=1953>varicose-vein " XBD=1942 XHG=1716 YBD=1998 YHG=1954>operations " XBD=2038 XHG=1966 YBD=1988 YHG=1953>has " XBD=2180 XHG=2061 YBD=1999 YHG=1954>given " XBD=2332 XHG=2210 YBD=1989 YHG=1953>much " XBD=2518 XHG=2356 YBD=1988 YHG=1953>concern" XBD=1381 XHG=1337 YBD=2037 YHG=2005>to " XBD=1529 XHG=1413 YBD=2037 YHG=2002>those " XBD=1803 XHG=1560 YBD=2048 YHG=2002>responsible " XBD=1897 XHG=1834 YBD=2037 YHG=2002>for " XBD=2084 XHG=1928 YBD=2038 YHG=2002>Service " XBD=2305 XHG=2115 YBD=2047 YHG=2003>patients. " XBD=2433 XHG=2369 YBD=2037 YHG=2002>An " XBD=2516 XHG=2462 YBD=2036 YHG=2002>in-" XBD=1516 XHG=1339 YBD=2097 YHG=2051>creasing " XBD=1706 XHG=1537 YBD=2086 YHG=2051>number " XBD=1773 XHG=1728 YBD=2086 YHG=2050>of " XBD=1977 XHG=1789 YBD=2097 YHG=2063>surgeons " XBD=2127 XHG=1997 YBD=2098 YHG=2051>prefer " XBD=2191 XHG=2147 YBD=2086 YHG=2054>to " XBD=2265 XHG=2212 YBD=2086 YHG=2052>do " XBD=2311 XHG=2287 YBD=2086 YHG=2064>a " XBD=2521 XHG=2326 YBD=2097 YHG=2051>thorough

Trendeenburg " XBD=1908 XHG=1689 YBD=2146 YHG=2101>operation. " XBD=2045 XHG=1962 YBD=2135 YHG=2101>The " XBD=2297 XHG=2072 YBD=2146 YHG=2100>saphenous " XBD=2416 XHG=2323 YBD=2135 YHG=2100>vein " XBD=2518 XHG=2442 YBD=2135 YHG=2100>and" XBD=1391 XHG=1338 YBD=2184 YHG=2149>its " XBD=1639 XHG=1406 YBD=2187 YHG=2149>tributaries " XBD=1720 XHG=1653 YBD=2184 YHG=2161>are " XBD=1932 XHG=1734 YBD=2195 YHG=2149>ligatured " XBD=1992 XHG=1946 YBD=2184 YHG=2153>at " XBD=2075 XHG=2005 YBD=2184 YHG=2149>the " XBD=2196 XHG=2088 YBD=2184 YHG=2149>fossa " XBD=2350 XHG=2211 YBD=2191 YHG=2149>ovalis, " XBD=2517 XHG=2366 YBD=2184 YHG=2148>further" XBD=1635 XHG=1339 YBD=2233 YHG=2198>subcutaneous " XBD=1838 XHG=1649 YBD=2244 YHG=2198>ligatures " XBD=1924 XHG=1857 YBD=2233 YHG=2209>are " XBD=2042 XHG=1938 YBD=2233 YHG=2199>done " XBD=2178 XHG=2059 YBD=2233 YHG=2198>lower " XBD=2327 XHG=2197 YBD=2240 YHG=2199>down, " XBD=2424 XHG=2343 YBD=2233 YHG=2199>and " XBD=2519 XHG=2441 YBD=2243 YHG=2209>any" XBD=1516 XHG=1337 YBD=2283 YHG=2247>varicose " XBD=1648 XHG=1541 YBD=2283 YHG=2259>mass " XBD=1706 XHG=1672 YBD=2282 YHG=2248>is " XBD=1913 XHG=1730 YBD=2289 YHG=2248>excised ; " XBD=2147 XHG=1953 YBD=2292 YHG=2247>injection " XBD=2343 XHG=2169 YBD=2294 YHG=2248>therapy " XBD=2400 XHG=2366 YBD=2282 YHG=2247>is " XBD=2517 XHG=2423 YBD=2282 YHG=2245>used" XBD=1401 XHG=1337 YBD=2331 YHG=2296>for " XBD=1517 XHG=1435 YBD=2342 YHG=2308>any " XBD=1769 XHG=1551 YBD=2332 YHG=2299>remnants. " XBD=2067 XHG=1822 YBD=2342 YHG=2296>Pulmonary " XBD=2282 XHG=2102 YBD=2333 YHG=2296>embolus " XBD=2436 XHG=2316 YBD=2332 YHG=2296>after " XBD=2519 XHG=2453 YBD=2331 YHG=2296>the" XBD=1509 XHG=1338 YBD=2391 YHG=2345>ligature " XBD=1620 XHG=1538 YBD=2380 YHG=2346>and " XBD=1838 XHG=1646 YBD=2390 YHG=2346>injection " XBD=2030 XHG=1864 YBD=2381 YHG=2346>method " XBD=2090 XHG=2057 YBD=2380 YHG=2347>is " XBD=2143 XHG=2119 YBD=2380 YHG=2358>a " XBD=2452 XHG=2172 YBD=2392 YHG=2345>complication " XBD=2519 XHG=2477 YBD=2380 YHG=2348>to" XBD=1390 XHG=1340 YBD=2429 YHG=2394>be " XBD=1577 XHG=1415 YBD=2437 YHG=2394>feared ; " XBD=1805 XHG=1604 YBD=2429 YHG=2394>non-fatal " XBD=1971 XHG=1825 YBD=2429 YHG=2394>emboli " XBD=2066 XHG=1997 YBD=2430 YHG=2406>are " XBD=2295 XHG=2096 YBD=2441 YHG=2395>probably " XBD=2516 XHG=2326 YBD=2430 YHG=2405>common." XBD=1423 XHG=1339 YBD=2478 YHG=2443>The " XBD=1562 XHG=1446 YBD=2477 YHG=2443>usual " XBD=1843 XHG=1585 YBD=2489 YHG=2443>explanation " XBD=1979 XHG=1860 YBD=2488 YHG=2444>given " XBD=2033 XHG=2000 YBD=2478 YHG=2445>is " XBD=2148 XHG=2055 YBD=2479 YHG=2444>that " XBD=2239 XHG=2170 YBD=2479 YHG=2444>the " XBD=2426 XHG=2257 YBD=2490 YHG=2444>ligature " XBD=2519 XHG=2448 YBD=2478 YHG=2444>site" XBD=1382 XHG=1339 YBD=2526 YHG=2492>in " XBD=1471 XHG=1401 YBD=2526 YHG=2492>the " XBD=1612 XHG=1489 YBD=2526 YHG=2491>fossal " XBD=1756 XHG=1631 YBD=2527 YHG=2491>ovalis " XBD=1847 XHG=1774 YBD=2527 YHG=2492>has " XBD=1967 XHG=1866 YBD=2526 YHG=2492>been " XBD=2054 XHG=1984 YBD=2527 YHG=2493>the " XBD=2378 XHG=2073 YBD=2539 YHG=2493>starting-point " XBD=2441 XHG=2395 YBD=2528 YHG=2491>of " XBD=2520 XHG=2454 YBD=2527 YHG=2492>the" XBD=1434 XHG=1341 YBD=2576 YHG=2540>clot. " XBD=1540 XHG=1488 YBD=2575 YHG=2541>In " XBD=1631 XHG=1561 YBD=2575 YHG=2541>the " XBD=1755 XHG=1653 YBD=2586 YHG=2541>light " XBD=1822 XHG=1778 YBD=2576 YHG=2541>of " XBD=2011 XHG=1839 YBD=2576 YHG=2541>ATLAS’S " XBD=2217 XHG=2032 YBD=2587 YHG=2541>findings, " XBD=2311 XHG=2241 YBD=2576 YHG=2543>the " XBD=2520 XHG=2333 YBD=2586 YHG=2541>injection" XBD=1439 XHG=1339 YBD=2624 YHG=2589>fluid " XBD=1588 XHG=1461 YBD=2625 YHG=2601>seems " XBD=1654 XHG=1611 YBD=2624 YHG=2593>to " XBD=1727 XHG=1677 YBD=2624 YHG=2590>be " XBD=1817 XHG=1748 YBD=2624 YHG=2590>the " XBD=1966 XHG=1840 YBD=2625 YHG=2590>direct " XBD=2104 XHG=1989 YBD=2625 YHG=2601>cause " XBD=2172 XHG=2127 YBD=2625 YHG=2590>of " XBD=2259 XHG=2189 YBD=2625 YHG=2591>the " XBD=2519 XHG=2282 YBD=2625 YHG=2590>thrombosis" XBD=1386 XHG=1341 YBD=2673 YHG=2638>of " XBD=1492 XHG=1421 YBD=2673 YHG=2639>the " XBD=1633 XHG=1532 YBD=2683 YHG=2639>deep " XBD=1810 XHG=1673 YBD=2673 YHG=2639>vessel. " XBD=1906 XHG=1865 YBD=2673 YHG=2639>It " XBD=2076 XHG=1945 YBD=2674 YHG=2639>would " XBD=2166 XHG=2117 YBD=2683 YHG=2639>be " XBD=2441 XHG=2204 YBD=2674 YHG=2639>instructive " XBD=2519 XHG=2477 YBD=2672 YHG=2641>to" XBD=1459 XHG=1340 YBD=2722 YHG=2687>know " XBD=1662 XHG=1483 YBD=2722 YHG=2687>whether " XBD=1893 XHG=1687 YBD=2723 YHG=2688>embolism " XBD=1991 XHG=1918 YBD=2722 YHG=2688>has " XBD=2199 XHG=2016 YBD=2723 YHG=2687>followed " XBD=2391 XHG=2223 YBD=2733 YHG=2687>ligation " XBD=2517 XHG=2415 YBD=2732 YHG=2687>only," XBD=1513 XHG=1341 YBD=2771 YHG=2737>without " XBD=1613 XHG=1531 YBD=2781 YHG=2748>any " XBD=1820 XHG=1628 YBD=2781 YHG=2737>injection " XBD=2019 XHG=1836 YBD=2782 YHG=2737>therapy." XBD=1626 XHG=1394 YBD=2825 YHG=2789>Individual " XBD=1884 XHG=1656 YBD=2835 YHG=2790>sensitivity " XBD=1956 XHG=1913 YBD=2824 YHG=2793>to " XBD=2203 XHG=1985 YBD=2835 YHG=2789>particular " XBD=2425 XHG=2232 YBD=2825 YHG=2790>solutions " XBD=2520 XHG=2452 YBD=2824 YHG=2790>has" XBD=1444 XHG=1342 YBD=2873 YHG=2838>been " XBD=1687 XHG=1457 YBD=2883 YHG=2839>recognised " XBD=1744 XHG=1701 YBD=2873 YHG=2850>as " XBD=1811 XHG=1759 YBD=2873 YHG=2850>an " XBD=2040 XHG=1823 YBD=2873 YHG=2838>incidental " XBD=2203 XHG=2053 YBD=2872 YHG=2838>hazard " XBD=2322 XHG=2216 YBD=2872 YHG=2839>since " XBD=2521 XHG=2335 YBD=2882 YHG=2838>injection" XBD=1564 XHG=1342 YBD=2921 YHG=2890>treatment " XBD=1623 XHG=1578 YBD=2921 YHG=2886>of " XBD=1744 XHG=1632 YBD=2921 YHG=2888>veins " XBD=1836 XHG=1757 YBD=2922 YHG=2899>was " XBD=1935 XHG=1849 YBD=2921 YHG=2887>first " XBD=2114 XHG=1949 YBD=2921 YHG=2887>started. " XBD=2345 XHG=2168 YBD=2931 YHG=2882>Perhaps " XBD=2520 XHG=2358 YBD=2922 YHG=2886>because" XBD=1418 XHG=1343 YBD=2970 YHG=2947>one " XBD=1481 XHG=1436 YBD=2970 YHG=2935>of " XBD=1557 XHG=1493 YBD=2970 YHG=2936>his " XBD=1688 XHG=1574 YBD=2969 YHG=2935>clinic " XBD=1882 XHG=1705 YBD=2980 YHG=2936>patients " XBD=1991 XHG=1899 YBD=2970 YHG=2935>died " XBD=2109 XHG=2007 YBD=2969 YHG=2935>from " XBD=2152 XHG=2128 YBD=2969 YHG=2946>a " XBD=2270 XHG=2168 YBD=2969 YHG=2934>fatal " XBD=2461 XHG=2286 YBD=2969 YHG=2935>reaction " XBD=2518 XHG=2477 YBD=2969 YHG=2937>to" XBD=1507 XHG=1344 YBD=3029 YHG=2984>quinine " XBD=1605 XHG=1524 YBD=3018 YHG=2984>and " XBD=1826 XHG=1621 YBD=3025 YHG=2984>urethane, " XBD=1980 XHG=1844 YBD=3018 YHG=2984>ATLAS " XBD=2197 XHG=1999 YBD=3018 YHG=2984>considers " XBD=2246 XHG=2213 YBD=3018 YHG=2984>it " XBD=2287 XHG=2262 YBD=3017 YHG=2995>a " XBD=2530 XHG=2303 YBD=3028 YHG=2983>dangerous-" XBD=1444 XHG=1343 YBD=3078 YHG=3033>drug " XBD=1562 XHG=1480 YBD=3067 YHG=3033>and " XBD=1756 XHG=1599 YBD=3067 YHG=3033>advises " XBD=1884 XHG=1792 YBD=3067 YHG=3033>that " XBD=1973 XHG=1920 YBD=3066 YHG=3033>its " XBD=2070 XHG=2001 YBD=3066 YHG=3043>use " XBD=2250 XHG=2107 YBD=3066 YHG=3031>should " XBD=2337 XHG=2288 YBD=3066 YHG=3032>be " XBD=2520 XHG=2373 YBD=3067 YHG=3029>discon-" XBD=1495 XHG=1342 YBD=3116 YHG=3081>tinued. " XBD=1614 XHG=1550 YBD=3115 YHG=3081>He " XBD=1732 XHG=1631 YBD=3115 YHG=3084>tests " XBD=1818 XHG=1748 YBD=3115 YHG=3081>the " XBD=2061 XHG=1835 YBD=3125 YHG=3081>sensitivity " XBD=2124 XHG=2078 YBD=3114 YHG=3079>of " XBD=2206 XHG=2137 YBD=3114 YHG=3080>the " XBD=2380 XHG=2222 YBD=3125 YHG=3080>patient " XBD=2439 XHG=2396 YBD=3114 YHG=3083>to " XBD=2520 XHG=2455 YBD=3114 YHG=3080>the" XBD=1555 XHG=1343 YBD=3174 YHG=3129>sclerosing " XBD=1757 XHG=1583 YBD=3163 YHG=3129>solution " XBD=1839 XHG=1784 YBD=3173 YHG=3129>by " XBD=1889 XHG=1865 YBD=3163 YHG=3141>a " XBD=2013 XHG=1916 YBD=3173 YHG=3140>very " XBD=2155 XHG=2040 YBD=3162 YHG=3128>small " XBD=2439 XHG=2181 YBD=3163 YHG=3129>intravenous " XBD=2518 XHG=2464 YBD=3162 YHG=3129>in-" XBD=1504 XHG=1341 YBD=3222 YHG=3178>jection, " XBD=1749 XHG=1522 YBD=3222 YHG=3177>preferably " XBD=1881 XHG=1764 YBD=3221 YHG=3177>given " XBD=1992 XHG=1906 YBD=3211 YHG=3177>into " XBD=2077 XHG=2008 YBD=3211 YHG=3177>the " XBD=2208 XHG=2093 YBD=3211 YHG=3177>varix " XBD=2266 XHG=2232 YBD=3211 YHG=3177>it " XBD=2315 XHG=2282 YBD=3211 YHG=3177>is " XBD=2520 XHG=2331 YBD=3223 YHG=3175>proposed" XBD=1387 XHG=1342 YBD=3260 YHG=3229>to " XBD=1657 XHG=1413 YBD=3260 YHG=3225>thrombose. " XBD=1746 XHG=1711 YBD=3259 YHG=3225>A " XBD=2004 XHG=1772 YBD=3270 YHG=3225>tourniquet " XBD=2189 XHG=2029 YBD=3271 YHG=3225>applied " XBD=2259 XHG=2215 YBD=3260 YHG=3236>so " XBD=2376 XHG=2285 YBD=3260 YHG=3225>that " XBD=2433 XHG=2400 YBD=3260 YHG=3226>it " XBD=2520 XHG=2457 YBD=3259 YHG=3225>fits" XBD=1428 XHG=1313 YBD=3308 YHG=3270>into " XBD=1533 XHG=1462 YBD=3308 YHG=3274>the " XBD=1698 XHG=1568 YBD=3308 YHG=3285>crease " XBD=1880 XHG=1732 YBD=3308 YHG=3274>behind " XBD=1982 XHG=1913 YBD=3308 YHG=3274>the " XBD=2115 XHG=2014 YBD=3308 YHG=3274>knee " XBD=2227 XHG=2148 YBD=3309 YHG=3273>will " XBD=2420 XHG=2261 YBD=3309 YHG=3273>occlude " XBD=2518 XHG=2452 YBD=3309 YHG=3274>the" XBD=1461 XHG=1341 YBD=3356 YHG=3322>lesser " XBD=1718 XHG=1493 YBD=3367 YHG=3322>saphenous " XBD=1841 XHG=1748 YBD=3356 YHG=3322>vein " XBD=2004 XHG=1872 YBD=3357 YHG=3322>before " XBD=2086 XHG=2033 YBD=3357 YHG=3323>its " XBD=2299 XHG=2116 YBD=3367 YHG=3323>junction " XBD=2424 XHG=2329 YBD=3357 YHG=3323>with " XBD=2519 XHG=2453 YBD=3358 YHG=3323>the" XBD=1538 XHG=1342 YBD=3415 YHG=3370>popliteal " XBD=1657 XHG=1553 YBD=3405 YHG=3371>vein. " XBD=1793 XHG=1711 YBD=3405 YHG=3370>The " XBD=1965 XHG=1809 YBD=3415 YHG=3371>patient " XBD=2158 XHG=1987 YBD=3406 YHG=3372>remains " XBD=2368 XHG=2180 YBD=3417 YHG=3372>standing during

2. Heller, R. E. Ibid, 1942, 74, 1118.

343

" XBD=238 XHG=173 YBD=222 YHG=186>the " XBD=445 XHG=258 YBD=233 YHG=187>injection " XBD=546 XHG=465 YBD=222 YHG=187>and " XBD=628 XHG=567 YBD=222 YHG=187>for " XBD=727 XHG=649 YBD=222 YHG=187>five " XBD=922 XHG=748 YBD=222 YHG=187>minutes " XBD=1047 XHG=943 YBD=222 YHG=186>after " XBD=1112 XHG=1067 YBD=227 YHG=187>it, " XBD=1250 XHG=1135 YBD=221 YHG=186>when " XBD=1341 XHG=1270 YBD=221 YHG=186>the" XBD=392 XHG=168 YBD=283 YHG=236>tourniquet " XBD=446 XHG=414 YBD=270 YHG=237>is " XBD=657 XHG=468 YBD=271 YHG=235>removed " XBD=760 XHG=680 YBD=271 YHG=236>and " XBD=833 XHG=782 YBD=270 YHG=236>he " XBD=889 XHG=855 YBD=270 YHG=234>is " XBD=997 XHG=911 YBD=270 YHG=234>told " XBD=1063 XHG=1020 YBD=270 YHG=238>to " XBD=1189 XHG=1086 YBD=269 YHG=234>walk " XBD=1338 XHG=1212 YBD=269 YHG=233>about" XBD=209 XHG=169 YBD=320 YHG=288>to " XBD=394 XHG=225 YBD=330 YHG=285>disperse " XBD=491 XHG=410 YBD=330 YHG=296>any " XBD=681 XHG=507 YBD=320 YHG=284>solution " XBD=801 XHG=697 YBD=320 YHG=283>from " XBD=887 XHG=817 YBD=319 YHG=284>the " XBD=1003 XHG=904 YBD=329 YHG=285>deep " XBD=1171 XHG=1020 YBD=319 YHG=295>venous " XBD=1339 XHG=1189 YBD=328 YHG=286>system" XBD=211 XHG=168 YBD=368 YHG=334>of " XBD=287 XHG=220 YBD=369 YHG=334>the " XBD=360 XHG=300 YBD=379 YHG=333>leg " XBD=418 XHG=375 YBD=368 YHG=345>or " XBD=558 XHG=432 YBD=379 YHG=333>thigh. " XBD=769 XHG=612 YBD=375 YHG=334>DODD,s on " XBD=920 XHG=851 YBD=368 YHG=333>the " XBD=1050 XHG=935 YBD=368 YHG=333>other " XBD=1185 XHG=1063 YBD=374 YHG=332>hand, " XBD=1339 XHG=1201 YBD=366 YHG=332>thinks" XBD=315 XHG=168 YBD=418 YHG=383>sodium " XBD=571 XHG=344 YBD=417 YHG=382>morrhuate " XBD=701 XHG=600 YBD=417 YHG=381>both " XBD=952 XHG=729 YBD=416 YHG=381>ineffective " XBD=1062 XHG=981 YBD=416 YHG=381>and " XBD=1338 XHG=1090 YBD=426 YHG=381>dangerous ;" XBD=214 XHG=167 YBD=466 YHG=432>he " XBD=300 XHG=230 YBD=465 YHG=431>has " XBD=437 XHG=316 YBD=466 YHG=430>heard " XBD=500 XHG=455 YBD=465 YHG=430>of " XBD=665 XHG=514 YBD=466 YHG=430>several " XBD=826 XHG=683 YBD=465 YHG=430>deaths " XBD=923 XHG=843 YBD=465 YHG=430>and " XBD=1077 XHG=939 YBD=465 YHG=430>knows " XBD=1210 XHG=1096 YBD=465 YHG=430>other " XBD=1337 XHG=1229 YBD=464 YHG=441>cases" XBD=210 XHG=168 YBD=515 YHG=479>of " XBD=509 XHG=234 YBD=525 YHG=478>anaphylactic " XBD=712 XHG=541 YBD=524 YHG=478>collapse " XBD=846 XHG=742 YBD=514 YHG=478>after " XBD=928 XHG=875 YBD=513 YHG=479>its " XBD=1040 XHG=958 YBD=514 YHG=490>use. " XBD=1157 XHG=1093 YBD=514 YHG=480>He " XBD=1220 XHG=1187 YBD=513 YHG=478>is " XBD=1341 XHG=1251 YBD=513 YHG=490>now" XBD=295 XHG=167 YBD=574 YHG=528>trying " XBD=420 XHG=324 YBD=574 YHG=528>30% " XBD=585 XHG=451 YBD=569 YHG=528>saline, " XBD=746 XHG=617 YBD=563 YHG=528>which " XBD=847 XHG=775 YBD=563 YHG=527>has " XBD=945 XHG=876 YBD=562 YHG=528>the " XBD=1092 XHG=974 YBD=563 YHG=528>merit " XBD=1167 XHG=1123 YBD=563 YHG=528>of " XBD=1336 XHG=1193 YBD=573 YHG=527>safety." XBD=302 XHG=165 YBD=613 YHG=578>Where " XBD=394 XHG=325 YBD=612 YHG=577>the " XBD=584 XHG=419 YBD=612 YHG=576>femoral " XBD=703 XHG=609 YBD=612 YHG=577>vein " XBD=800 XHG=727 YBD=612 YHG=577>has " XBD=925 XHG=826 YBD=612 YHG=577>been " XBD=1034 XHG=950 YBD=611 YHG=577>tied " XBD=1101 XHG=1059 YBD=611 YHG=577>in " XBD=1232 XHG=1127 YBD=612 YHG=588>error " XBD=1338 XHG=1258 YBD=612 YHG=577>and" XBD=343 XHG=165 YBD=671 YHG=626>injected, " XBD=414 XHG=363 YBD=661 YHG=625>he " XBD=588 XHG=433 YBD=661 YHG=626>advises " XBD=702 XHG=609 YBD=661 YHG=626>that " XBD=790 XHG=721 YBD=660 YHG=626>the " XBD=977 XHG=809 YBD=671 YHG=625>ligature " XBD=1141 XHG=998 YBD=661 YHG=626>should " XBD=1337 XHG=1159 YBD=661 YHG=627>immedi-" XBD=269 XHG=166 YBD=720 YHG=674>ately " XBD=348 XHG=299 YBD=710 YHG=674>be " XBD=530 XHG=379 YBD=717 YHG=675>untied, " XBD=635 XHG=564 YBD=710 YHG=675>the " XBD=787 XHG=668 YBD=710 YHG=674>blood " XBD=984 XHG=820 YBD=710 YHG=675>allowed " XBD=1060 XHG=1016 YBD=710 YHG=678>to " XBD=1220 XHG=1093 YBD=721 YHG=687>sweep " XBD=1337 XHG=1253 YBD=717 YHG=679>out," XBD=241 XHG=165 YBD=759 YHG=724>and " XBD=329 XHG=261 YBD=759 YHG=723>the " XBD=440 XHG=349 YBD=759 YHG=724>vein " XBD=663 XHG=461 YBD=770 YHG=724>irrigated. " XBD=822 XHG=718 YBD=759 YHG=723>Such " XBD=1065 XHG=843 YBD=759 YHG=724>accidental " XBD=1277 XHG=1085 YBD=769 YHG=725>injection " XBD=1343 XHG=1299 YBD=760 YHG=724>of" XBD=230 XHG=164 YBD=807 YHG=773>the " XBD=414 XHG=252 YBD=808 YHG=772>femoral " XBD=533 XHG=441 YBD=808 YHG=774>vein " XBD=633 XHG=560 YBD=808 YHG=774>has " XBD=759 XHG=659 YBD=808 YHG=773>been " XBD=967 XHG=785 YBD=808 YHG=772>followed " XBD=1050 XHG=994 YBD=819 YHG=774>by " XBD=1270 XHG=1073 YBD=819 YHG=785>gangrene " XBD=1342 XHG=1298 YBD=809 YHG=772>of" XBD=229 XHG=163 YBD=857 YHG=822>the " XBD=330 XHG=245 YBD=867 YHG=821>leg ; " XBD=565 XHG=364 YBD=868 YHG=821>similarly, " XBD=655 XHG=583 YBD=857 YHG=822>the " XBD=894 XHG=672 YBD=857 YHG=822>accidental " XBD=1101 XHG=910 YBD=867 YHG=822>injection " XBD=1163 XHG=1119 YBD=857 YHG=822>of " XBD=1338 XHG=1177 YBD=869 YHG=823>quinine" XBD=240 XHG=163 YBD=906 YHG=871>and " XBD=449 XHG=257 YBD=906 YHG=864>urethane " XBD=554 XHG=467 YBD=906 YHG=871>into " XBD=598 XHG=574 YBD=906 YHG=883>a " XBD=718 XHG=618 YBD=917 YHG=871>deep " XBD=871 XHG=738 YBD=916 YHG=874>artery " XBD=935 XHG=892 YBD=906 YHG=871>of " XBD=1020 XHG=950 YBD=906 YHG=871>the " XBD=1100 XHG=1039 YBD=917 YHG=871>leg " XBD=1192 XHG=1119 YBD=906 YHG=872>has " XBD=1275 XHG=1210 YBD=906 YHG=871>led " XBD=1338 XHG=1294 YBD=907 YHG=875>to" XBD=352 XHG=162 YBD=965 YHG=930>gangrene " XBD=412 XHG=367 YBD=955 YHG=919>of " XBD=491 XHG=422 YBD=954 YHG=920>the " XBD=606 XHG=506 YBD=955 YHG=919>foot. " XBD=743 XHG=661 YBD=955 YHG=920>But " XBD=957 XHG=759 YBD=966 YHG=920>emphasis " XBD=1025 XHG=973 YBD=955 YHG=932>on " XBD=1153 XHG=1041 YBD=955 YHG=920>these " XBD=1338 XHG=1170 YBD=955 YHG=921>hazards" XBD=290 XHG=161 YBD=1014 YHG=969>paints " XBD=377 XHG=313 YBD=1003 YHG=966>far " XBD=465 XHG=397 YBD=1004 YHG=973>too " XBD=651 XHG=489 YBD=1015 YHG=968>gloomy " XBD=699 XHG=674 YBD=1004 YHG=982>a " XBD=903 XHG=723 YBD=1015 YHG=969>picture ; " XBD=984 XHG=942 YBD=1004 YHG=970>in " XBD=1143 XHG=1008 YBD=1004 YHG=969>actual " XBD=1341 XHG=1166 YBD=1015 YHG=970>practice" XBD=227 XHG=161 YBD=1052 YHG=1017>the " XBD=387 XHG=247 YBD=1053 YHG=1018>results " XBD=453 XHG=409 YBD=1064 YHG=1018>of " XBD=640 XHG=469 YBD=1064 YHG=1018>ligature " XBD=743 XHG=663 YBD=1054 YHG=1019>and " XBD=962 XHG=770 YBD=1064 YHG=1019>injection " XBD=1052 XHG=985 YBD=1053 YHG=1030>are " XBD=1340 XHG=1079 YBD=1065 YHG=1019>particularly" XBD=293 XHG=159 YBD=1113 YHG=1067>happy " XBD=430 XHG=323 YBD=1102 YHG=1056>and " XBD=626 XHG=435 YBD=1103 YHG=1068>curative. " XBD=736 XHG=680 YBD=1103 YHG=1068>At " XBD=838 XHG=768 YBD=1103 YHG=1069>the " XBD=989 XHG=869 YBD=1114 YHG=1069>Mayo " XBD=1174 XHG=1023 YBD=1110 YHG=1068>Clinic,4 " XBD=1338 XHG=1210 YBD=1103 YHG=1069>where" XBD=254 XHG=160 YBD=1162 YHG=1116>they " XBD=368 XHG=267 YBD=1152 YHG=1117>have " XBD=486 XHG=384 YBD=1152 YHG=1118>done " XBD=597 XHG=503 YBD=1152 YHG=1128>over " XBD=713 XHG=613 YBD=1153 YHG=1118>2900 " XBD=849 XHG=730 YBD=1160 YHG=1129>cases, " XBD=1153 XHG=868 YBD=1153 YHG=1117>simultaneous " XBD=1338 XHG=1168 YBD=1164 YHG=1118>ligature" XBD=236 XHG=160 YBD=1201 YHG=1166>and " XBD=455 XHG=266 YBD=1210 YHG=1165>injection " XBD=662 XHG=489 YBD=1201 YHG=1167>remains " XBD=766 XHG=697 YBD=1201 YHG=1167>the " XBD=917 XHG=802 YBD=1202 YHG=1166>usual " XBD=1126 XHG=951 YBD=1212 YHG=1168>practice " XBD=1203 XHG=1160 YBD=1202 YHG=1167>in " XBD=1335 XHG=1238 YBD=1212 YHG=1166>80%" XBD=202 XHG=160 YBD=1250 YHG=1214>of " XBD=350 XHG=233 YBD=1257 YHG=1226>cases, " XBD=451 XHG=382 YBD=1250 YHG=1215>the " XBD=708 XHG=486 YBD=1262 YHG=1216>remaining " XBD=841 XHG=743 YBD=1262 YHG=1215>20% " XBD=1074 XHG=873 YBD=1262 YHG=1216>requiring " XBD=1208 XHG=1113 YBD=1262 YHG=1216>only " XBD=1340 XHG=1238 YBD=1252 YHG=1215>local" XBD=420 XHG=161 YBD=1300 YHG=1264>obliteration.

HÆMOPOIETIC STIMULATORS ANDLEUKÆMIA

" XBD=537 XHG=208 YBD=1526 YHG=1491>SUPERFICIALLY " XBD=695 XHG=582 YBD=1526 YHG=1491>there " XBD=773 XHG=740 YBD=1525 YHG=1491>is " XBD=843 XHG=819 YBD=1526 YHG=1503>a " XBD=1025 XHG=889 YBD=1536 YHG=1494>strong " XBD=1337 XHG=1070 YBD=1526 YHG=1491>resemblance" XBD=333 XHG=162 YBD=1575 YHG=1539>between " XBD=425 XHG=356 YBD=1576 YHG=1541>the " XBD=700 XHG=449 YBD=1587 YHG=1540>histological " XBD=896 XHG=726 YBD=1586 YHG=1541>changes " XBD=1014 XHG=922 YBD=1575 YHG=1553>seen " XBD=1079 XHG=1038 YBD=1575 YHG=1541>in " XBD=1174 XHG=1105 YBD=1575 YHG=1541>the " XBD=1335 XHG=1199 YBD=1575 YHG=1540>blood-" XBD=323 XHG=159 YBD=1635 YHG=1589>forming " XBD=486 XHG=343 YBD=1625 YHG=1590>tissues " XBD=548 XHG=506 YBD=1625 YHG=1590>in " XBD=791 XHG=567 YBD=1636 YHG=1590>pernicious " XBD=980 XHG=812 YBD=1625 YHG=1591>anaemia " XBD=1080 XHG=1000 YBD=1625 YHG=1590>and " XBD=1368 XHG=1100 YBD=1631 YHG=1589>leukaemia ; -" XBD=253 XHG=160 YBD=1673 YHG=1638>both " XBD=377 XHG=270 YBD=1674 YHG=1639>show " XBD=547 XHG=391 YBD=1685 YHG=1639>greatly " XBD=766 XHG=562 YBD=1674 YHG=1640>increased " XBD=1005 XHG=783 YBD=1684 YHG=1639>cellularity " XBD=1117 XHG=1020 YBD=1674 YHG=1640>with " XBD=1335 XHG=1134 YBD=1685 YHG=1639>prolifera-" XBD=240 XHG=158 YBD=1723 YHG=1687>tion " XBD=314 XHG=270 YBD=1723 YHG=1688>of " XBD=649 XHG=340 YBD=1735 YHG=1689>erythropoietic " XBD=725 XHG=681 YBD=1724 YHG=1701>or " XBD=1014 XHG=754 YBD=1735 YHG=1689>leucopoietic " XBD=1199 XHG=1045 YBD=1729 YHG=1690>tissues. " XBD=1337 XHG=1254 YBD=1724 YHG=1688>But" XBD=264 XHG=159 YBD=1773 YHG=1738>there " XBD=345 XHG=278 YBD=1773 YHG=1738>the " XBD=625 XHG=356 YBD=1774 YHG=1739>resemblance " XBD=749 XHG=640 YBD=1774 YHG=1740>ends. " XBD=841 XHG=791 YBD=1773 YHG=1739>In " XBD=1073 XHG=851 YBD=1785 YHG=1739>pernicious " XBD=1252 XHG=1085 YBD=1774 YHG=1739>anaemia " XBD=1337 XHG=1269 YBD=1773 YHG=1739>the" XBD=422 XHG=157 YBD=1834 YHG=1786>proliferating " XBD=538 XHG=447 YBD=1823 YHG=1788>cells " XBD=630 XHG=563 YBD=1823 YHG=1800>are " XBD=805 XHG=654 YBD=1834 YHG=1788>largely " XBD=846 XHG=823 YBD=1823 YHG=1801>a " XBD=972 XHG=873 YBD=1823 YHG=1788>class " XBD=1035 XHG=991 YBD=1823 YHG=1788>of " XBD=1129 XHG=1058 YBD=1823 YHG=1788>cell " XBD=1225 XHG=1153 YBD=1823 YHG=1791>not " XBD=1336 XHG=1248 YBD=1822 YHG=1799>nor-" XBD=275 XHG=153 YBD=1884 YHG=1836>mally " XBD=450 XHG=291 YBD=1884 YHG=1841>present " XBD=519 XHG=475 YBD=1873 YHG=1841>at " XBD=592 XHG=538 YBD=1873 YHG=1838>all " XBD=657 XHG=615 YBD=1872 YHG=1838>in " XBD=790 XHG=676 YBD=1873 YHG=1837>adult " XBD=1118 XHG=808 YBD=1884 YHG=1837>blood-forming " XBD=1337 XHG=1141 YBD=1873 YHG=1838>tissues-" XBD=223 XHG=158 YBD=1922 YHG=1887>the " XBD=541 XHG=248 YBD=1934 YHG=1887>megaloblasts, " XBD=699 XHG=570 YBD=1922 YHG=1887>which " XBD=831 XHG=727 YBD=1923 YHG=1887>after " XBD=961 XHG=857 YBD=1923 YHG=1888>their " XBD=1146 XHG=988 YBD=1923 YHG=1887>fashion " XBD=1335 XHG=1173 YBD=1923 YHG=1887>become" XBD=318 XHG=157 YBD=1972 YHG=1940>mature. " XBD=421 XHG=371 YBD=1972 YHG=1937>In " XBD=654 XHG=444 YBD=1973 YHG=1937>leukaemia " XBD=748 XHG=678 YBD=1972 YHG=1937>the " XBD=878 XHG=773 YBD=1979 YHG=1936>cells, " XBD=1006 XHG=905 YBD=1972 YHG=1949>even " XBD=1184 XHG=1029 YBD=1983 YHG=1937>though " XBD=1333 XHG=1210 YBD=1972 YHG=1949>some-" XBD=268 XHG=143 YBD=2021 YHG=1987>times " XBD=509 XHG=296 YBD=2032 YHG=1986>primitive, " XBD=617 XHG=543 YBD=2021 YHG=1999>can " XBD=699 XHG=646 YBD=2021 YHG=1986>all " XBD=777 XHG=728 YBD=2021 YHG=1986>be " XBD=932 XHG=805 YBD=2021 YHG=1986>found " XBD=1003 XHG=960 YBD=2021 YHG=1987>in " XBD=1186 XHG=1031 YBD=2021 YHG=1986>normal " XBD=1333 XHG=1215 YBD=2021 YHG=1987>bone-" XBD=329 XHG=156 YBD=2078 YHG=2047>marrow, " XBD=439 XHG=365 YBD=2070 YHG=2036>but " XBD=579 XHG=473 YBD=2070 YHG=2036>their " XBD=862 XHG=613 YBD=2071 YHG=2036>maturation " XBD=930 XHG=896 YBD=2070 YHG=2036>is " XBD=1077 XHG=964 YBD=2071 YHG=2035>often " XBD=1333 XHG=1112 YBD=2071 YHG=2036>disturbed." XBD=275 XHG=157 YBD=2120 YHG=2084>These " XBD=542 XHG=311 YBD=2120 YHG=2085>differences " XBD=646 XHG=579 YBD=2120 YHG=2097>are " XBD=857 XHG=683 YBD=2131 YHG=2085>brought " XBD=966 XHG=895 YBD=2119 YHG=2088>out " XBD=1046 XHG=1003 YBD=2130 YHG=2085>in " XBD=1162 XHG=1081 YBD=2120 YHG=2088>two " XBD=1335 XHG=1199 YBD=2120 YHG=2088>recent" XBD=369 XHG=156 YBD=2169 YHG=2135>researches " XBD=461 XHG=408 YBD=2169 YHG=2146>on " XBD=774 XHG=498 YBD=2180 YHG=2134>haemopoietic " XBD=1072 XHG=814 YBD=2169 YHG=2134>stimulators. " XBD=1306 XHG=1127 YBD=2169 YHG=2134>LIMARZI " XBD=1334 XHG=1319 YBD=2156 YHG=2137>s" XBD=308 XHG=158 YBD=2219 YHG=2184>studied " XBD=395 XHG=325 YBD=2219 YHG=2184>the " XBD=530 XHG=413 YBD=2219 YHG=2184>effect " XBD=594 XHG=549 YBD=2219 YHG=2183>of " XBD=759 XHG=608 YBD=2219 YHG=2183>arsenic " XBD=831 XHG=778 YBD=2219 YHG=2195>on " XBD=918 XHG=847 YBD=2219 YHG=2183>the " XBD=1226 XHG=936 YBD=2219 YHG=2183>bone-marrow " XBD=1336 XHG=1244 YBD=2219 YHG=2183>cells

" XBD=194 XHG=155 YBD=2269 YHG=2233>in " XBD=433 XHG=214 YBD=2280 YHG=2233>pernicious " XBD=652 XHG=457 YBD=2276 YHG=2233>anaemia ; " XBD=843 XHG=692 YBD=2269 YHG=2234>arsenic " XBD=901 XHG=867 YBD=2268 YHG=2234>is " XBD=948 XHG=924 YBD=2268 YHG=2246>a " XBD=1150 XHG=972 YBD=2268 YHG=2232>classical " XBD=1336 XHG=1171 YBD=2279 YHG=2234>remedy" XBD=212 XHG=155 YBD=2318 YHG=2282>for " XBD=315 XHG=236 YBD=2319 YHG=2283>this " XBD=509 XHG=341 YBD=2318 YHG=2283>anaemia " XBD=616 XHG=535 YBD=2318 YHG=2284>and " XBD=723 XHG=641 YBD=2318 YHG=2295>was " XBD=899 XHG=750 YBD=2328 YHG=2282>always " XBD=1043 XHG=924 YBD=2328 YHG=2283>given " XBD=1111 XHG=1068 YBD=2317 YHG=2282>in " XBD=1207 XHG=1136 YBD=2317 YHG=2283>the " XBD=1334 XHG=1233 YBD=2328 YHG=2283>days" XBD=281 XHG=156 YBD=2368 YHG=2331>before " XBD=402 XHG=302 YBD=2367 YHG=2332>liver " XBD=613 XHG=424 YBD=2367 YHG=2335>extracts. " XBD=731 XHG=668 YBD=2367 YHG=2333>He " XBD=881 XHG=753 YBD=2368 YHG=2332>found " XBD=996 XHG=904 YBD=2367 YHG=2333>that " XBD=1170 XHG=1019 YBD=2367 YHG=2332>arsenic " XBD=1333 XHG=1195 YBD=2367 YHG=2332>stimu-" XBD=249 XHG=155 YBD=2417 YHG=2380>lates " XBD=337 XHG=269 YBD=2417 YHG=2382>the " XBD=640 XHG=358 YBD=2426 YHG=2381>development " XBD=708 XHG=662 YBD=2416 YHG=2381>of " XBD=989 XHG=723 YBD=2427 YHG=2381>haemoglobin " XBD=1052 XHG=1008 YBD=2416 YHG=2381>in " XBD=1141 XHG=1071 YBD=2416 YHG=2381>the " XBD=1332 XHG=1161 YBD=2427 YHG=2380>megalo-" XBD=285 XHG=156 YBD=2473 YHG=2430>blasts, " XBD=390 XHG=316 YBD=2465 YHG=2431>but " XBD=463 XHG=419 YBD=2466 YHG=2433>at " XBD=563 XHG=492 YBD=2465 YHG=2430>the " XBD=702 XHG=593 YBD=2465 YHG=2442>same " XBD=830 XHG=731 YBD=2466 YHG=2430>time " XBD=893 XHG=858 YBD=2465 YHG=2431>it " XBD=1081 XHG=920 YBD=2476 YHG=2431>poisons " XBD=1223 XHG=1111 YBD=2466 YHG=2431>them " XBD=1334 XHG=1253 YBD=2466 YHG=2431>and" XBD=308 XHG=155 YBD=2526 YHG=2479>hastens " XBD=408 XHG=338 YBD=2514 YHG=2480>the " XBD=750 XHG=432 YBD=2525 YHG=2480>disappearance " XBD=827 XHG=781 YBD=2515 YHG=2480>of " XBD=956 XHG=852 YBD=2515 YHG=2480>their " XBD=1143 XHG=986 YBD=2522 YHG=2480>nuclei ; " XBD=1271 XHG=1189 YBD=2515 YHG=2480>this " XBD=1334 XHG=1300 YBD=2515 YHG=2480>is" XBD=342 XHG=139 YBD=2570 YHG=2528>therefore " XBD=675 XHG=361 YBD=2575 YHG=2528>a-pathological " XBD=947 XHG=695 YBD=2565 YHG=2529>stimulation " XBD=1047 XHG=966 YBD=2564 YHG=2529>and " XBD=1099 XHG=1065 YBD=2564 YHG=2529>is " XBD=1215 XHG=1120 YBD=2575 YHG=2529>only " XBD=1333 XHG=1233 YBD=2565 YHG=2532>tem-" XBD=320 XHG=155 YBD=2625 YHG=2578>porarily " XBD=544 XHG=349 YBD=2614 YHG=2578>effective. " XBD=717 XHG=597 YBD=2614 YHG=2578>Liver " XBD=904 XHG=746 YBD=2614 YHG=2582>extract " XBD=965 XHG=932 YBD=2614 YHG=2579>is " XBD=1068 XHG=995 YBD=2614 YHG=2582>not " XBD=1333 XHG=1097 YBD=2614 YHG=2578>a &dquo; stimu-" XBD=289 XHG=153 YBD=2663 YHG=2627>lator &dquo; " XBD=368 XHG=323 YBD=2663 YHG=2628>of " XBD=557 XHG=395 YBD=2662 YHG=2627>red-cell " XBD=832 XHG=587 YBD=2670 YHG=2628>formation ; " XBD=914 XHG=881 YBD=2663 YHG=2629>it " XBD=979 XHG=945 YBD=2663 YHG=2628>is " XBD=1251 XHG=1011 YBD=2674 YHG=2628>apparently " XBD=1336 XHG=1282 YBD=2663 YHG=2639>an" XBD=331 XHG=155 YBD=2712 YHG=2677>essential " XBD=477 XHG=347 YBD=2711 YHG=2676>factor " XBD=551 XHG=488 YBD=2712 YHG=2677>for " XBD=640 XHG=569 YBD=2712 YHG=2677>the " XBD=900 XHG=658 YBD=2722 YHG=2678>production " XBD=963 XHG=918 YBD=2712 YHG=2677>of " XBD=1134 XHG=977 YBD=2712 YHG=2677>normal " XBD=1222 XHG=1148 YBD=2726 YHG=2678>red " XBD=1333 XHG=1241 YBD=2712 YHG=2677>cells" XBD=231 XHG=156 YBD=2761 YHG=2726>and " XBD=363 XHG=250 YBD=2761 YHG=2726>when " XBD=417 XHG=384 YBD=2761 YHG=2726>it " XBD=472 XHG=438 YBD=2762 YHG=2726>is " XBD=614 XHG=494 YBD=2772 YHG=2726>given " XBD=680 XHG=636 YBD=2761 YHG=2729>to " XBD=928 XHG=703 YBD=2771 YHG=2726>pernicious " XBD=1119 XHG=950 YBD=2762 YHG=2727>anaemia " XBD=1333 XHG=1148 YBD=2772 YHG=2719>patients" XBD=428 XHG=156 YBD=2811 YHG=2775>normoblastic " XBD=641 XHG=465 YBD=2821 YHG=2775>replaces " XBD=975 XHG=676 YBD=2821 YHG=2775>megaloblastic " XBD=1331 XHG=1011 YBD=2822 YHG=2776>erythropoiesis." XBD=231 XHG=155 YBD=2860 YHG=2823>The " XBD=414 XHG=248 YBD=2860 YHG=2825>absence " XBD=478 XHG=433 YBD=2860 YHG=2825>of " XBD=743 XHG=493 YBD=2860 YHG=2824>stimulators " XBD=856 XHG=761 YBD=2859 YHG=2825>does " XBD=947 XHG=874 YBD=2860 YHG=2829>not " XBD=1062 XHG=965 YBD=2871 YHG=2824>play " XBD=1161 XHG=1080 YBD=2870 YHG=2837>any " XBD=1272 XHG=1179 YBD=2871 YHG=2829>part " XBD=1333 XHG=1290 YBD=2859 YHG=2825>in" XBD=219 XHG=156 YBD=2908 YHG=2872>the " XBD=422 XHG=238 YBD=2919 YHG=2873>aetiology " XBD=489 XHG=444 YBD=2909 YHG=2874>of " XBD=732 XHG=507 YBD=2919 YHG=2873>pernicious " XBD=934 XHG=754 YBD=2909 YHG=2874>anaemia. &dquo;

" XBD=440 XHG=199 YBD=2957 YHG=2922>Leukaemias " XBD=530 XHG=462 YBD=2957 YHG=2934>are " XBD=659 XHG=552 YBD=2957 YHG=2925>most " XBD=911 XHG=683 YBD=2967 YHG=2922>commonly " XBD=1076 XHG=931 YBD=2958 YHG=2923>looked " XBD=1151 XHG=1099 YBD=2957 YHG=2934>on " XBD=1217 XHG=1173 YBD=2957 YHG=2935>as " XBD=1330 XHG=1238 YBD=2958 YHG=2934>neo-" XBD=286 XHG=154 YBD=3015 YHG=2970>plastic " XBD=342 XHG=301 YBD=3005 YHG=2971>in " XBD=605 XHG=356 YBD=3013 YHG=2972>nature, but " XBD=663 XHG=619 YBD=3005 YHG=2972>in " XBD=772 XHG=676 YBD=3006 YHG=2983>man |>" XBD=1006 XHG=787 YBD=3017 YHG=2965>especially’ " XBD=1126 XHG=1013 YBD=3006 YHG=2972>there " XBD=1207 XHG=1142 YBD=3005 YHG=2983>are " XBD=1332 XHG=1222 YBD=3006 YHG=2983>some" XBD=249 XHG=153 YBD=3055 YHG=3018>facts " XBD=363 XHG=274 YBD=3055 YHG=3020>that " XBD=457 XHG=391 YBD=3055 YHG=3032>are " XBD=654 XHG=484 YBD=3055 YHG=3020>difficult " XBD=724 XHG=679 YBD=3056 YHG=3024>to " XBD=798 XHG=750 YBD=3055 YHG=3019>fit " XBD=866 XHG=824 YBD=3055 YHG=3020>in " XBD=989 XHG=892 YBD=3056 YHG=3021>with " XBD=1097 XHG=1015 YBD=3055 YHG=3021>this " XBD=1224 XHG=1123 YBD=3055 YHG=3021>view " XBD=1331 XHG=1250 YBD=3056 YHG=3021>and" XBD=296 XHG=156 YBD=3103 YHG=3069>several " XBD=451 XHG=315 YBD=3103 YHG=3069>efforts " XBD=578 XHG=474 YBD=3104 YHG=3070>have " XBD=704 XHG=602 YBD=3104 YHG=3070>been " XBD=843 XHG=725 YBD=3104 YHG=3069>made " XBD=911 XHG=867 YBD=3104 YHG=3073>to " XBD=996 XHG=929 YBD=3115 YHG=3074>get " XBD=1132 XHG=1020 YBD=3104 YHG=3071>them " XBD=1241 XHG=1155 YBD=3104 YHG=3069>into " XBD=1330 XHG=1260 YBD=3104 YHG=3069>the" XBD=399 XHG=159 YBD=3163 YHG=3116>&dquo; deficiency " XBD=603 XHG=410 YBD=3153 YHG=3118>disease &dquo; " XBD=737 XHG=624 YBD=3153 YHG=3118>class. |>" XBD=930 XHG=764 YBD=3154 YHG=3119>MILLER " XBD=1025 XHG=945 YBD=3153 YHG=3119>and " XBD=1100 XHG=1039 YBD=3152 YHG=3118>his " XBD=1331 XHG=1118 YBD=3153 YHG=3119>associates" XBD=192 XHG=154 YBD=3200 YHG=3164>in Philadelphia " XBD=627 XHG=490 YBD=3202 YHG=3167>6 have " XBD=737 XHG=645 YBD=3202 YHG=3179>now " XBD=1015 XHG=753 YBD=3212 YHG=3167>propounded " XBD=1058 XHG=1034 YBD=3201 YHG=3179>a " XBD=1219 XHG=1075 YBD=3212 YHG=3166>theory " XBD=1329 XHG=1237 YBD=3202 YHG=3167>that" XBD=321 XHG=156 YBD=3259 YHG=3214>explains " XBD=554 XHG=346 YBD=3250 YHG=3215>leukaemia " XBD=634 XHG=581 YBD=3250 YHG=3227>on " XBD=730 XHG=660 YBD=3251 YHG=3216>the " XBD=862 XHG=756 YBD=3250 YHG=3216>basis " XBD=933 XHG=889 YBD=3250 YHG=3215>of " XBD=979 XHG=955 YBD=3250 YHG=3227>a " XBD=1278 XHG=1006 YBD=3250 YHG=3216>disturbance of

" XBD=218 XHG=155 YBD=3298 YHG=3262>the " XBD=390 XHG=239 YBD=3308 YHG=3264>specific " XBD=658 XHG=410 YBD=3299 YHG=3265>stimulators " XBD=723 XHG=678 YBD=3299 YHG=3265>of " XBD=928 XHG=742 YBD=3309 YHG=3264>myeloid, " XBD=1034 XHG=942 YBD=3308 YHG=3265>(i.e., " XBD=1328 XHG=1054 YBD=3309 YHG=3265>granulocyte-3. Dodd, H. Proc. R. Soc. Med. 1943, 36, 191.4. Larson, R. A. and Smith, F. L. Proc. Mayo Clin. 1943, 18, 400.5. Limarzi, L. R. Amer. J. med. Sci. 1943, 206, 339. 6. Miller, F. R. and Turner, D. L. Ibid, p. 146.

" XBD=1593 XHG=1405 YBD=232 YHG=186>forming) " XBD=1711 XHG=1630 YBD=221 YHG=187>and |>" XBD=1972 XHG=1744 YBD=233 YHG=186>lymphoid " XBD=2143 XHG=1987 YBD=223 YHG=187>tissues. " XBD=2311 XHG=2198 YBD=232 YHG=187>They " XBD=2472 XHG=2344 YBD=221 YHG=186>found " XBD=2601 XHG=2506 YBD=223 YHG=187>that" XBD=1508 XHG=1404 YBD=270 YHG=234>from " XBD=1600 XHG=1529 YBD=270 YHG=235>the " XBD=1734 XHG=1621 YBD=270 YHG=236>urine " XBD=1801 XHG=1756 YBD=271 YHG=234>of " XBD=1994 XHG=1816 YBD=281 YHG=236>patients " XBD=2112 XHG=2015 YBD=271 YHG=236>with " XBD=2342 XHG=2132 YBD=271 YHG=235>leukaemia " XBD=2599 XHG=2363 YBD=271 YHG=236>substances" XBD=1524 XHG=1406 YBD=318 YHG=283>could " XBD=1586 XHG=1537 YBD=318 YHG=284>be " XBD=1792 XHG=1601 YBD=319 YHG=284>obtained " XBD=1934 XHG=1805 YBD=320 YHG=284>which " XBD=2062 XHG=1948 YBD=321 YHG=285>when " XBD=2250 XHG=2074 YBD=330 YHG=284>injected " XBD=2350 XHG=2263 YBD=319 YHG=285>into " XBD=2598 XHG=2364 YBD=330 YHG=284>guineapigs" XBD=1551 XHG=1406 YBD=366 YHG=332>caused " XBD=1854 XHG=1577 YBD=378 YHG=332>proliferation " XBD=1925 XHG=1880 YBD=369 YHG=334>of " XBD=2051 XHG=1947 YBD=369 YHG=334>their " XBD=2251 XHG=2076 YBD=379 YHG=332>myeloid " XBD=2360 XHG=2277 YBD=368 YHG=333>and " XBD=2596 XHG=2384 YBD=378 YHG=332>lymphoid" XBD=1576 XHG=1404 YBD=422 YHG=380>tissues ; " XBD=1841 XHG=1610 YBD=427 YHG=381>guineapigs " XBD=1959 XHG=1858 YBD=417 YHG=394>were " XBD=2122 XHG=1977 YBD=418 YHG=383>chosen " XBD=2307 XHG=2139 YBD=417 YHG=382>because " XBD=2598 XHG=2326 YBD=427 YHG=384>spontaneous" XBD=1615 XHG=1404 YBD=464 YHG=429>leukaemia " XBD=1683 XHG=1650 YBD=464 YHG=430>is " XBD=1805 XHG=1718 YBD=464 YHG=441>rare " XBD=1986 XHG=1841 YBD=476 YHG=442>among " XBD=2144 XHG=2021 YBD=466 YHG=432>them. " XBD=2325 XHG=2199 YBD=466 YHG=431>These " XBD=2597 XHG=2361 YBD=465 YHG=430>substances" XBD=1576 XHG=1402 YBD=513 YHG=478>induced |>" XBD=1775 XHG=1605 YBD=528 YHG=478>changes " XBD=1844 XHG=1800 YBD=513 YHG=479>in " XBD=1939 XHG=1869 YBD=514 YHG=479>the " XBD=2176 XHG=1965 YBD=525 YHG=480>guineapig " XBD=2347 XHG=2202 YBD=515 YHG=479>tissues " XBD=2525 XHG=2374 YBD=515 YHG=478>similar " XBD=2596 XHG=2551 YBD=513 YHG=481>to" XBD=1520 XHG=1403 YBD=564 YHG=528>those " XBD=1631 XHG=1538 YBD=562 YHG=539>seen " XBD=1690 XHG=1648 YBD=562 YHG=528>in " XBD=1777 XHG=1707 YBD=563 YHG=526>the " XBD=1947 XHG=1794 YBD=563 YHG=527>human " XBD=2234 XHG=1964 YBD=573 YHG=528>subject-for " XBD=2447 XHG=2251 YBD=574 YHG=528>example, " XBD=2509 XHG=2466 YBD=563 YHG=528>in " XBD=2597 XHG=2526 YBD=564 YHG=528>the" XBD=1515 XHG=1403 YBD=619 YHG=577>liver, " XBD=1651 XHG=1537 YBD=612 YHG=577>urine " XBD=1774 XHG=1671 YBD=612 YHG=576>from " XBD=1818 XHG=1794 YBD=611 YHG=589>a " XBD=1928 XHG=1840 YBD=612 YHG=588>case " XBD=1994 XHG=1949 YBD=612 YHG=577>of " XBD=2170 XHG=2011 YBD=612 YHG=578>chronic " XBD=2366 XHG=2190 YBD=623 YHG=577>myeloid " XBD=2596 XHG=2385 YBD=613 YHG=578>leukaemia" XBD=1552 XHG=1406 YBD=662 YHG=627>caused " XBD=1851 XHG=1576 YBD=673 YHG=626>proliferation " XBD=1920 XHG=1876 YBD=660 YHG=626>of " XBD=2219 XHG=1940 YBD=672 YHG=626>granulocytes " XBD=2432 XHG=2243 YBD=672 YHG=626>diffusely " XBD=2594 XHG=2449 YBD=673 YHG=626>spread" XBD=1584 XHG=1404 YBD=712 YHG=677>between " XBD=1679 XHG=1608 YBD=710 YHG=675>the " XBD=1817 XHG=1704 YBD=711 YHG=675>cords " XBD=1887 XHG=1843 YBD=710 YHG=674>of " XBD=2006 XHG=1906 YBD=710 YHG=675>liver " XBD=2149 XHG=2032 YBD=717 YHG=675>cells ; " XBD=2302 XHG=2190 YBD=710 YHG=676>urine " XBD=2430 XHG=2326 YBD=710 YHG=675>from " XBD=2480 XHG=2456 YBD=711 YHG=688>a " XBD=2595 XHG=2506 YBD=711 YHG=687>case" XBD=1449 XHG=1403 YBD=761 YHG=725>of " XBD=1633 XHG=1472 YBD=761 YHG=725>chronic " XBD=1883 XHG=1660 YBD=771 YHG=724>lymphatic |>" XBD=2118 XHG=1909 YBD=759 YHG=724>leukaemia " XBD=2291 XHG=2145 YBD=759 YHG=724>caused " XBD=2595 XHG=2317 YBD=770 YHG=724>proliferation" XBD=1485 XHG=1404 YBD=811 YHG=775>and " XBD=1809 XHG=1512 YBD=810 YHG=774>accumulation |>" XBD=1881 XHG=1826 YBD=809 YHG=774>-of " XBD=2183 XHG=1902 YBD=820 YHG=773>lymphocytes " XBD=2252 XHG=2209 YBD=808 YHG=774>in " XBD=2348 XHG=2278 YBD=809 YHG=774>the " XBD=2595 XHG=2374 YBD=819 YHG=774>periportal" XBD=1534 XHG=1403 YBD=860 YHG=836>zones. " XBD=1712 XHG=1588 YBD=860 YHG=824>Urine " XBD=1832 XHG=1727 YBD=860 YHG=823>from " XBD=1957 XHG=1849 YBD=859 YHG=835>cases " XBD=2018 XHG=1973 YBD=859 YHG=823>of " XBD=2147 XHG=2031 YBD=858 YHG=826>acute " XBD=2374 XHG=2163 YBD=858 YHG=822>leukaemia " XBD=2595 XHG=2390 YBD=869 YHG=823>produced" XBD=1576 XHG=1405 YBD=919 YHG=873>changes " XBD=1760 XHG=1611 YBD=909 YHG=874>similar " XBD=1837 XHG=1793 YBD=909 YHG=877>to " XBD=1986 XHG=1871 YBD=908 YHG=873>those " XBD=2123 XHG=2019 YBD=907 YHG=872>from " XBD=2226 XHG=2156 YBD=907 YHG=872>the " XBD=2421 XHG=2262 YBD=907 YHG=872>chronic " XBD=2593 XHG=2457 YBD=914 YHG=883>cases ;" XBD=1520 XHG=1402 YBD=958 YHG=926>acute " XBD=1772 XHG=1543 YBD=968 YHG=924>monocytic " XBD=2003 XHG=1794 YBD=957 YHG=922>leukaemia " XBD=2172 XHG=2027 YBD=956 YHG=921>caused " XBD=2220 XHG=2195 YBD=956 YHG=933>a " XBD=2378 XHG=2242 YBD=956 YHG=921>mixed " XBD=2592 XHG=2401 YBD=966 YHG=921>myeloid-" XBD=1614 XHG=1403 YBD=1018 YHG=972>lymphoid " XBD=1910 XHG=1624 YBD=1018 YHG=972>proliferation. " XBD=2017 XHG=1965 YBD=1007 YHG=971>So " XBD=2089 XHG=2027 YBD=1006 YHG=971>far " XBD=2211 XHG=2100 YBD=1006 YHG=971>there " XBD=2372 XHG=2222 YBD=1016 YHG=982>appear " XBD=2426 XHG=2382 YBD=1006 YHG=974>to " XBD=2487 XHG=2438 YBD=1005 YHG=971>be " XBD=2580 XHG=2497 YBD=1006 YHG=974>two" XBD=1596 XHG=1402 YBD=1057 YHG=1021>fractions " XBD=1844 XHG=1613 YBD=1057 YHG=1021>obtainable " XBD=1962 XHG=1859 YBD=1056 YHG=1021>from " XBD=2048 XHG=1977 YBD=1056 YHG=1021>the " XBD=2176 XHG=2063 YBD=1055 YHG=1021>urine " XBD=2237 XHG=2192 YBD=1056 YHG=1020>of " XBD=2453 XHG=2247 YBD=1056 YHG=1020>leukaemic " XBD=2592 XHG=2471 YBD=1063 YHG=1032>cases," XBD=1479 XHG=1404 YBD=1106 YHG=1083>one " XBD=1980 XHG=1499 YBD=1117 YHG=1071>lymphoid-stimulating " XBD=2082 XHG=2001 YBD=1106 YHG=1071>and " XBD=2178 XHG=2104 YBD=1106 YHG=1082>one " XBD=2592 XHG=2199 YBD=1116 YHG=1069>myeloid-stimulat-" XBD=1498 XHG=1404 YBD=1166 YHG=1121>ing ; " XBD=1585 XHG=1542 YBD=1155 YHG=1121>in " XBD=1770 XHG=1614 YBD=1156 YHG=1120>normal " XBD=1909 XHG=1796 YBD=1156 YHG=1121>urine " XBD=2038 XHG=1938 YBD=1166 YHG=1121>they " XBD=2184 XHG=2067 YBD=1155 YHG=1120>could " XBD=2285 XHG=2213 YBD=1155 YHG=1123>not " XBD=2364 XHG=2314 YBD=1155 YHG=1120>be " XBD=2592 XHG=2393 YBD=1155 YHG=1120>detected." XBD=1694 XHG=1401 YBD=1212 YHG=1170>Nevertheless, " XBD=1791 XHG=1721 YBD=1205 YHG=1170>the " XBD=2094 XHG=1816 YBD=1215 YHG=1169>Philadelphia " XBD=2291 XHG=2119 YBD=1204 YHG=1169>workers " XBD=2475 XHG=2316 YBD=1204 YHG=1180>assume " XBD=2594 XHG=2500 YBD=1204 YHG=1169>that" XBD=1515 XHG=1402 YBD=1254 YHG=1219>these " XBD=1792 XHG=1544 YBD=1255 YHG=1219>stimulators " XBD=1887 XHG=1820 YBD=1254 YHG=1231>are " XBD=2075 XHG=1914 YBD=1265 YHG=1222>present " XBD=2145 XHG=2103 YBD=1254 YHG=1219>in " XBD=2242 XHG=2172 YBD=1254 YHG=1219>the " XBD=2426 XHG=2270 YBD=1254 YHG=1218>normal " XBD=2591 XHG=2455 YBD=1254 YHG=1217>blood-" XBD=1577 XHG=1402 YBD=1311 YHG=1271>stream ; " XBD=1711 XHG=1612 YBD=1314 YHG=1269>they " XBD=1883 XHG=1728 YBD=1304 YHG=1268>further " XBD=2057 XHG=1900 YBD=1304 YHG=1280>assume " XBD=2168 XHG=2075 YBD=1304 YHG=1269>that " XBD=2255 XHG=2186 YBD=1304 YHG=1269>the " XBD=2509 XHG=2274 YBD=1305 YHG=1269>substances " XBD=2594 XHG=2527 YBD=1304 YHG=1280>are|>" XBD=1647 XHG=1405 YBD=1364 YHG=1317>6 4 mutually " XBD=1928 XHG=1673 YBD=1364 YHG=1317>reciprocal&dquo; " XBD=2000 XHG=1958 YBD=1353 YHG=1319>in " XBD=2290 XHG=2028 YBD=1361 YHG=1318>action-i.e., " XBD=2390 XHG=2320 YBD=1354 YHG=1319>the " XBD=2594 XHG=2418 YBD=1364 YHG=1318>myeloid" XBD=1617 XHG=1403 YBD=1403 YHG=1368>substance " XBD=1859 XHG=1634 YBD=1403 YHG=1368>stimulates " XBD=2148 XHG=1874 YBD=1413 YHG=1367>proliferation " XBD=2209 XHG=2164 YBD=1403 YHG=1368>of " XBD=2501 XHG=2220 YBD=1414 YHG=1367>granulocytes " XBD=2593 XHG=2518 YBD=1404 YHG=1368>but" XBD=1496 XHG=1400 YBD=1452 YHG=1418>does " XBD=1582 XHG=1509 YBD=1452 YHG=1421>not " XBD=1712 XHG=1594 YBD=1453 YHG=1417>make " XBD=1837 XHG=1725 YBD=1453 YHG=1417>them " XBD=2032 XHG=1850 YBD=1459 YHG=1421>mature ; " XBD=2311 XHG=2061 YBD=1453 YHG=1419>maturation " XBD=2356 XHG=2322 YBD=1453 YHG=1418>is " XBD=2592 XHG=2370 YBD=1453 YHG=1417>controlled" XBD=1458 XHG=1402 YBD=1512 YHG=1467>by " XBD=1544 XHG=1473 YBD=1502 YHG=1467>the " XBD=1771 XHG=1560 YBD=1512 YHG=1466>lymphoid " XBD=2001 XHG=1789 YBD=1502 YHG=1467>substance " XBD=2147 XHG=2018 YBD=1501 YHG=1466>which " XBD=2248 XHG=2165 YBD=1502 YHG=1466>also " XBD=2339 XHG=2265 YBD=1502 YHG=1467>has " XBD=2381 XHG=2357 YBD=1502 YHG=1479>a " XBD=2592 XHG=2398 YBD=1513 YHG=1467>damping" XBD=1519 XHG=1401 YBD=1552 YHG=1517>effect " XBD=1594 XHG=1541 YBD=1552 YHG=1528>on " XBD=1914 XHG=1615 YBD=1562 YHG=1516>proliferation ; " XBD=2034 XHG=1953 YBD=1551 YHG=1516>and " XBD=2141 XHG=2054 YBD=1551 YHG=1516>vice " XBD=2277 XHG=2161 YBD=1552 YHG=1528>versa " XBD=2360 XHG=2297 YBD=1552 YHG=1516>for " XBD=2592 XHG=2380 YBD=1563 YHG=1517>lymphoid" XBD=1556 XHG=1400 YBD=1601 YHG=1566>tissues. " XBD=1777 XHG=1610 YBD=1602 YHG=1565>Normal " XBD=2044 XHG=1826 YBD=1601 YHG=1566>formation " XBD=2140 XHG=2096 YBD=1601 YHG=1565>of " XBD=2307 XHG=2187 YBD=1612 YHG=1566>white " XBD=2592 XHG=2360 YBD=1602 YHG=1566>blood-cells" XBD=1577 XHG=1400 YBD=1662 YHG=1616>depends " XBD=1655 XHG=1602 YBD=1650 YHG=1627>on " XBD=1746 XHG=1677 YBD=1650 YHG=1615>the " XBD=1965 XHG=1770 YBD=1650 YHG=1615>balanced " XBD=2122 XHG=1986 YBD=1650 YHG=1616>action " XBD=2190 XHG=2145 YBD=1650 YHG=1615>of " XBD=2320 XHG=2208 YBD=1651 YHG=1607>these " XBD=2425 XHG=2344 YBD=1651 YHG=1619>two " XBD=2589 XHG=2449 YBD=1651 YHG=1616>stimu-" XBD=1759 XHG=1397 YBD=1707 YHG=1665>lator-inhibitors ; " XBD=1824 XHG=1789 YBD=1699 YHG=1664>if " XBD=1915 XHG=1834 YBD=1701 YHG=1665>this " XBD=2096 XHG=1929 YBD=1700 YHG=1664>balance " XBD=2142 XHG=2109 YBD=1700 YHG=1665>is " XBD=2366 XHG=2157 YBD=1701 YHG=1665>disturbed " XBD=2590 XHG=2379 YBD=1701 YHG=1665>leukaemia" XBD=1496 XHG=1399 YBD=1761 YHG=1727>may " XBD=1674 XHG=1537 YBD=1750 YHG=1715>result. " XBD=1837 XHG=1728 YBD=1750 YHG=1715>Thus " XBD=2040 XHG=1882 YBD=1750 YHG=1715>chronic " XBD=2258 XHG=2083 YBD=1760 YHG=1715>myeloid " XBD=2512 XHG=2301 YBD=1751 YHG=1715>leukaemia " XBD=2589 XHG=2556 YBD=1750 YHG=1716>is" XBD=1612 XHG=1400 YBD=1811 YHG=1765>explained " XBD=1699 XHG=1643 YBD=1810 YHG=1765>by " XBD=2066 XHG=1730 YBD=1810 YHG=1765>overproduction " XBD=2142 XHG=2097 YBD=1799 YHG=1765>of " XBD=2343 XHG=2167 YBD=1811 YHG=1764>myeloid " XBD=2590 XHG=2374 YBD=1800 YHG=1765>substance" XBD=1497 XHG=1398 YBD=1849 YHG=1815>with " XBD=1673 XHG=1517 YBD=1850 YHG=1814>normal " XBD=1934 XHG=1693 YBD=1860 YHG=1814>production " XBD=1999 XHG=1954 YBD=1849 YHG=1814>of " XBD=2223 XHG=2014 YBD=1861 YHG=1814>lymphoid " XBD=2288 XHG=2244 YBD=1850 YHG=1826>so " XBD=2402 XHG=2308 YBD=1850 YHG=1814>that " XBD=2536 XHG=2422 YBD=1850 YHG=1815>there " XBD=2590 XHG=2556 YBD=1849 YHG=1815>is" XBD=1737 XHG=1400 YBD=1911 YHG=1864>overproduction " XBD=1828 XHG=1783 YBD=1900 YHG=1864>of " XBD=2027 XHG=1870 YBD=1900 YHG=1867>mature " XBD=2378 XHG=2073 YBD=1910 YHG=1864>granulocytes ; " XBD=2477 XHG=2441 YBD=1899 YHG=1864>if " XBD=2590 XHG=2520 YBD=1900 YHG=1864>the" XBD=1608 XHG=1397 YBD=1960 YHG=1914>lymphoid " XBD=1850 XHG=1637 YBD=1949 YHG=1914>substance " XBD=2059 XHG=1877 YBD=1950 YHG=1915>becomes " XBD=2308 XHG=2086 YBD=1950 YHG=1914>exhausted " XBD=2448 XHG=2335 YBD=1949 YHG=1914>there " XBD=2509 XHG=2474 YBD=1948 YHG=1915>is " XBD=2589 XHG=2536 YBD=1949 YHG=1926>an" XBD=1424 XHG=1401 YBD=1977 YHG=1963>&dquo; " XBD=1559 XHG=1441 YBD=1999 YHG=1967>acute " XBD=1908 XHG=1577 YBD=1999 YHG=1963>transformation " XBD=2338 XHG=1926 YBD=2009 YHG=1963>&dquo;-overproduction " XBD=2401 XHG=2355 YBD=1998 YHG=1963>of " XBD=2590 XHG=2413 YBD=2009 YHG=1962>myeloid" XBD=1492 XHG=1399 YBD=2049 YHG=2013>cells " XBD=1688 XHG=1516 YBD=2048 YHG=2013>without " XBD=1972 XHG=1711 YBD=2048 YHG=2010>maturation. " XBD=2154 XHG=2025 YBD=2049 YHG=2013>Acute " XBD=2354 XHG=2178 YBD=2059 YHG=2013>myeloid " XBD=2588 XHG=2377 YBD=2048 YHG=2013>leukaemia" XBD=1493 XHG=1395 YBD=2109 YHG=2074>may " XBD=1568 XHG=1519 YBD=2098 YHG=2063>be " XBD=1674 XHG=1595 YBD=2099 YHG=2063>due " XBD=1744 XHG=1700 YBD=2098 YHG=2066>to " XBD=1800 XHG=1776 YBD=2098 YHG=2075>a " XBD=2049 XHG=1832 YBD=2110 YHG=2063>deficiency " XBD=2118 XHG=2076 YBD=2098 YHG=2063>of " XBD=2352 XHG=2142 YBD=2111 YHG=2063>lymphoid " XBD=2587 XHG=2382 YBD=2110 YHG=2062>(myeloid-" XBD=1617 XHG=1395 YBD=2158 YHG=2113>maturing) " XBD=1904 XHG=1651 YBD=2156 YHG=2110>substance ; " XBD=2079 XHG=1962 YBD=2149 YHG=2116>acute " XBD=2342 XHG=2114 YBD=2159 YHG=2113>monocytic " XBD=2588 XHG=2378 YBD=2150 YHG=2111>leukaemia" XBD=1432 XHG=1397 YBD=2196 YHG=2162>is " XBD=1597 XHG=1460 YBD=2196 YHG=2161>rather " XBD=1889 XHG=1629 YBD=2208 YHG=2161>surprisingly " XBD=1994 XHG=1918 YBD=2208 YHG=2165>put " XBD=2142 XHG=2025 YBD=2197 YHG=2162>down " XBD=2216 XHG=2170 YBD=2197 YHG=2164>to " XBD=2383 XHG=2248 YBD=2197 YHG=2173>excess " XBD=2460 XHG=2414 YBD=2197 YHG=2160>of " XBD=2588 XHG=2487 YBD=2197 YHG=2161>both" XBD=1573 XHG=1397 YBD=2257 YHG=2210>myeloid " XBD=1676 XHG=1595 YBD=2246 YHG=2211>and " XBD=1905 XHG=1696 YBD=2258 YHG=2211>lymphoid " XBD=2187 XHG=1928 YBD=2253 YHG=2212>substances ; " XBD=2397 XHG=2226 YBD=2257 YHG=2211>aplastic " XBD=2588 XHG=2418 YBD=2247 YHG=2211>anaemia" XBD=1435 XHG=1401 YBD=2296 YHG=2261>is " XBD=1659 XHG=1452 YBD=2307 YHG=2261>produced " XBD=1732 XHG=1676 YBD=2307 YHG=2261>by " XBD=1966 XHG=1748 YBD=2308 YHG=2261>deficiency " XBD=2027 XHG=1982 YBD=2296 YHG=2261>of " XBD=2138 XHG=2039 YBD=2297 YHG=2261>both " XBD=2316 XHG=2154 YBD=2296 YHG=2261>factors." XBD=1543 XHG=1447 YBD=2345 YHG=2310>This " XBD=1651 XHG=1554 YBD=2356 YHG=2323>may " XBD=1750 XHG=1662 YBD=2346 YHG=2311>well " XBD=1867 XHG=1762 YBD=2347 YHG=2323>seem " XBD=1931 XHG=1879 YBD=2349 YHG=2324>an " XBD=2145 XHG=1944 YBD=2346 YHG=2311>elaborate " XBD=2393 XHG=2157 YBD=2345 YHG=2310>theoretical " XBD=2588 XHG=2405 YBD=2346 YHG=2309>scaffold-" XBD=1464 XHG=1396 YBD=2406 YHG=2360>ing " XBD=1522 XHG=1477 YBD=2395 YHG=2363>to " XBD=1643 XHG=1536 YBD=2395 YHG=2363>erect " XBD=1709 XHG=1658 YBD=2395 YHG=2372>on " XBD=1792 XHG=1722 YBD=2395 YHG=2361>the " XBD=1912 XHG=1806 YBD=2396 YHG=2361>basis " XBD=1972 XHG=1926 YBD=2396 YHG=2361>of " XBD=2092 XHG=1980 YBD=2396 YHG=2360>these " XBD=2255 XHG=2106 YBD=2395 YHG=2359>animal " XBD=2590 XHG=2269 YBD=2405 YHG=2360>experiments-" XBD=1467 XHG=1397 YBD=2444 YHG=2412>too " XBD=1699 XHG=1496 YBD=2445 YHG=2409>elaborate " XBD=1898 XHG=1726 YBD=2456 YHG=2410>perhaps " XBD=1969 XHG=1925 YBD=2445 YHG=2413>to " XBD=2113 XHG=1998 YBD=2454 YHG=2420>carry " XBD=2503 XHG=2141 YBD=2444 YHG=2408>conviction-and " XBD=2589 XHG=2530 YBD=2443 YHG=2420>we" XBD=1547 XHG=1399 YBD=2493 YHG=2462>cannot " XBD=1658 XHG=1564 YBD=2505 YHG=2458>help " XBD=1964 XHG=1676 YBD=2505 YHG=2459>remembering " XBD=2073 XHG=1981 YBD=2494 YHG=2459>that " XBD=2203 XHG=2091 YBD=2493 YHG=2458>there " XBD=2254 XHG=2221 YBD=2492 YHG=2458>is " XBD=2297 XHG=2273 YBD=2492 YHG=2469>a " XBD=2588 XHG=2315 YBD=2493 YHG=2457>well-stocked" XBD=1621 XHG=1396 YBD=2553 YHG=2508>graveyard " XBD=1685 XHG=1640 YBD=2543 YHG=2508>of " XBD=1872 XHG=1699 YBD=2543 YHG=2508>theories " XBD=2016 XHG=1889 YBD=2543 YHG=2508>about " XBD=2253 XHG=2033 YBD=2542 YHG=2507>leukaemia. " XBD=2588 XHG=2305 YBD=2543 YHG=2507>Nevertheless" XBD=1467 XHG=1396 YBD=2592 YHG=2557>the " XBD=1632 XHG=1486 YBD=2603 YHG=2558>theory " XBD=1729 XHG=1650 YBD=2593 YHG=2557>will " XBD=1851 XHG=1747 YBD=2592 YHG=2558>have " XBD=1913 XHG=1870 YBD=2592 YHG=2561>to " XBD=1983 XHG=1934 YBD=2591 YHG=2557>be " XBD=2185 XHG=2001 YBD=2592 YHG=2556>followed " XBD=2271 XHG=2204 YBD=2602 YHG=2567>up, " XBD=2417 XHG=2293 YBD=2592 YHG=2556>based " XBD=2481 XHG=2436 YBD=2592 YHG=2568>as " XBD=2534 XHG=2499 YBD=2592 YHG=2557>it " XBD=2586 XHG=2552 YBD=2592 YHG=2557>is" XBD=1451 XHG=1398 YBD=2642 YHG=2618>on " XBD=1661 XHG=1469 YBD=2642 YHG=2606>clear-cut " XBD=1827 XHG=1678 YBD=2642 YHG=2606>animal " XBD=2216 XHG=1845 YBD=2651 YHG=2605>experimentation, " XBD=2316 XHG=2236 YBD=2641 YHG=2606>and " XBD=2368 XHG=2333 YBD=2641 YHG=2606>it " XBD=2458 XHG=2384 YBD=2641 YHG=2606>has " XBD=2587 XHG=2476 YBD=2642 YHG=2618>some" XBD=1616 XHG=1398 YBD=2691 YHG=2657>attractive " XBD=1787 XHG=1640 YBD=2701 YHG=2656>points. " XBD=1883 XHG=1842 YBD=2689 YHG=2655>It " XBD=2087 XHG=1907 YBD=2700 YHG=2654>explains " XBD=2181 XHG=2111 YBD=2689 YHG=2655>the " XBD=2399 XHG=2200 YBD=2701 YHG=2654>clinically " XBD=2587 XHG=2416 YBD=2701 YHG=2656>striking" XBD=1609 XHG=1397 YBD=2740 YHG=2705>difference " XBD=1828 XHG=1649 YBD=2740 YHG=2706>between " XBD=1984 XHG=1868 YBD=2738 YHG=2706>acute " XBD=2105 XHG=2024 YBD=2738 YHG=2703>and " XBD=2303 XHG=2144 YBD=2739 YHG=2703>chronic " XBD=2586 XHG=2342 YBD=2747 YHG=2704>leukaemias," XBD=1564 XHG=1396 YBD=2800 YHG=2754>ranging " XBD=1671 XHG=1600 YBD=2789 YHG=2754>the " XBD=1852 XHG=1705 YBD=2788 YHG=2753>former " XBD=1984 XHG=1887 YBD=2787 YHG=2752>with " XBD=2242 XHG=2019 YBD=2798 YHG=2753>pernicious " XBD=2446 XHG=2278 YBD=2789 YHG=2754>anaemia " XBD=2528 XHG=2482 YBD=2789 YHG=2766>as " XBD=2587 XHG=2563 YBD=2788 YHG=2766>a" XBD=1615 XHG=1396 YBD=2849 YHG=2803>deficiency " XBD=1866 XHG=1638 YBD=2838 YHG=2803>disease-a " XBD=2106 XHG=1889 YBD=2847 YHG=2801>deficiency " XBD=2220 XHG=2127 YBD=2837 YHG=2802>that " XBD=2318 XHG=2244 YBD=2837 YHG=2814>can " XBD=2514 XHG=2341 YBD=2850 YHG=2803>perhaps " XBD=2587 XHG=2537 YBD=2838 YHG=2803>be" XBD=1573 XHG=1394 YBD=2888 YHG=2852>rectified " XBD=1686 XHG=1587 YBD=2888 YHG=2852>with " XBD=1771 XHG=1700 YBD=2886 YHG=2852>the " XBD=2011 XHG=1784 YBD=2896 YHG=2850>possibility " XBD=2070 XHG=2026 YBD=2885 YHG=2851>of " XBD=2317 XHG=2082 YBD=2898 YHG=2852>controlling " XBD=2402 XHG=2332 YBD=2887 YHG=2853>the " XBD=2588 XHG=2415 YBD=2899 YHG=2852>tragedy" XBD=1441 XHG=1396 YBD=2935 YHG=2900>of " XBD=1580 XHG=1462 YBD=2936 YHG=2904>acute " XBD=1825 XHG=1604 YBD=2935 YHG=2901>leukaemia. " XBD=1921 XHG=1881 YBD=2934 YHG=2900>It " XBD=2060 XHG=1945 YBD=2934 YHG=2900>holds " XBD=2157 XHG=2086 YBD=2935 YHG=2904>out " XBD=2284 XHG=2181 YBD=2947 YHG=2901>hope " XBD=2356 XHG=2310 YBD=2936 YHG=2901>of " XBD=2586 XHG=2376 YBD=2946 YHG=2902>obtaining" XBD=1565 XHG=1394 YBD=2984 YHG=2949>efficient " XBD=1741 XHG=1600 YBD=2995 YHG=2952>agents " XBD=1837 XHG=1774 YBD=2983 YHG=2948>for " XBD=1940 XHG=1870 YBD=2982 YHG=2949>the " XBD=2223 XHG=1973 YBD=2995 YHG=2949>therapeutic " XBD=2510 XHG=2257 YBD=2985 YHG=2950>stimulation " XBD=2591 XHG=2545 YBD=2984 YHG=2948>of" XBD=1655 XHG=1393 YBD=3043 YHG=2997>granulocyte " XBD=1763 XHG=1682 YBD=3033 YHG=2998>and " XBD=2048 XHG=1788 YBD=3043 YHG=2997>lymphocyte " XBD=2326 XHG=2074 YBD=3044 YHG=2998>production. " XBD=2584 XHG=2379 YBD=3033 YHG=2997>MILLER’S" XBD=1504 XHG=1393 YBD=3082 YHG=3047>ideas " XBD=1630 XHG=1532 YBD=3081 YHG=3047>offer " XBD=1916 XHG=1653 YBD=3084 YHG=3045>well-defined " XBD=2077 XHG=1943 YBD=3092 YHG=3047>points " XBD=2194 XHG=2100 YBD=3084 YHG=3048>that " XBD=2297 XHG=2222 YBD=3083 YHG=3060>can " XBD=2370 XHG=2320 YBD=3083 YHG=3049>be " XBD=2585 XHG=2392 YBD=3092 YHG=3047>repeated" XBD=1474 XHG=1393 YBD=3130 YHG=3096>and " XBD=1626 XHG=1494 YBD=3130 YHG=3096>tested " XBD=1701 XHG=1647 YBD=3140 YHG=3095>by " XBD=1976 XHG=1720 YBD=3130 YHG=3095>others-the " XBD=2243 XHG=1994 YBD=3142 YHG=3096>histological " XBD=2434 XHG=2263 YBD=3141 YHG=3096>changes " XBD=2495 XHG=2452 YBD=3130 YHG=3096>in " XBD=2585 XHG=2515 YBD=3129 YHG=3095>the" XBD=1607 XHG=1393 YBD=3189 YHG=3144>guineapig " XBD=1738 XHG=1634 YBD=3178 YHG=3143>have " XBD=1930 XHG=1766 YBD=3189 YHG=3144>already " XBD=2057 XHG=1957 YBD=3180 YHG=3145>been " XBD=2301 XHG=2085 YBD=3180 YHG=3145>confirmed " XBD=2385 XHG=2329 YBD=3189 YHG=3145>by " XBD=2584 XHG=2411 YBD=3178 YHG=3141>HEiisLE" XBD=1476 XHG=1394 YBD=3227 YHG=3192>and " XBD=1563 XHG=1501 YBD=3226 YHG=3192>his |>" XBD=1867 XHG=1591 YBD=3238 YHG=3192>colleagues 7 ; " XBD=2061 XHG=1894 YBD=3229 YHG=3194>MILLER " XBD=2166 XHG=2088 YBD=3228 YHG=3194>will " XBD=2389 XHG=2194 YBD=3237 YHG=3192>certainly " XBD=2584 XHG=2414 YBD=3237 YHG=3191>develop" XBD=1505 XHG=1392 YBD=3276 YHG=3242>them " XBD=1612 XHG=1530 YBD=3276 YHG=3242>and " XBD=1696 XHG=1638 YBD=3276 YHG=3253>we " XBD=1825 XHG=1721 YBD=3288 YHG=3242>hope " XBD=1985 XHG=1853 YBD=3277 YHG=3243>others " XBD=2091 XHG=2011 YBD=3277 YHG=3242>will " XBD=2159 XHG=2117 YBD=3276 YHG=3253>as " XBD=2299 XHG=2186 YBD=3282 YHG=3241>well ; " XBD=2384 XHG=2341 YBD=3275 YHG=3241>in " XBD=2515 XHG=2410 YBD=3286 YHG=3240>spite " XBD=2587 XHG=2541 YBD=3274 YHG=3240>of" XBD=1615 XHG=1391 YBD=3335 YHG=3290>legitimate " XBD=1870 XHG=1641 YBD=3336 YHG=3292>scepticism " XBD=1982 XHG=1901 YBD=3326 YHG=3291>this " XBD=2141 XHG=2017 YBD=3325 YHG=3302>seems " XBD=2199 XHG=2175 YBD=3324 YHG=3302>a " XBD=2396 XHG=2231 YBD=3334 YHG=3288>hopeful " XBD=2509 XHG=2420 YBD=3323 YHG=3289>line " XBD=2587 XHG=2542 YBD=3323 YHG=3288>of" XBD=1568 XHG=1393 YBD=3383 YHG=3338>inquiry.

7. Heinle, R. W., Wearn, J. T., Weir, D. R. and Rose, F. A. Ann.int. Med. 1942, 17, 902.