Healthy Joints for Life, Rich Diana, M.D.

BIBLIOGRAPHY

Inflammation: The Cornerstone of Disease Almonte-Becceril M, Navarro-Garcia F, Gonzalez-Robles A, Vega-Lopez MA, Lavalle C, Kouri JB. “Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model,” Apoptosis. 2010 May; 15(5):631-8. Attur M, Samuels J, Krasnokutsky S, Abramson SB. “Targeting the synovial tissue for treating osteoarthritis (OA): where is the evidence?” Best Pract Res Clin Rheumatol. 2010 Feb; 24(1):71-9. Baldwin AS. Series Introduction: “The transcription factor NF-kB and human disease,” J. Clin Invest. 2001 January 1; 107(1):3-6. Checker, R. "Potent anti-inflammatory activity of ursolic acid, a triterpenoid antioxidant, is mediated through suppression of NF-KB, AP-1 and NF- AT.." PLoS One. 7.2 (2012): e31318. Chen F, Castranova V, Shi X, Demers LM. “New insights into the role of nuclear factor- kappaB, a ubiquitous transcription factor in the initiation of diseases,” Clin Chem. 1999 Jan;45(1):7-17. Chung HY, Kim HJ, Kim JW, Yu BP. “The inflammation hypothesis of aging: molecular modulation by calorie restriction,” Ann NY Acad Sci. 2001 Pri; 928:327-35. Csisar A, Wang M, Lakatta EG, Ungvari Z. “Inflammation and endothelial dysfunction during aging: role of NF-Kb,” J Appl Physiol. 2008 105:1333-1341. Fernandes JC, Martel-Pelletier J, Pelletier JP. “The role of cytokines in osteoarthritis patho- physiology,” Biorheology. 2002;39(1-2):237-46. Goldring, MB. “Update on the biology of the chondrocyte and the new approaches to treating cartilage diseases,” Best Pract Res Clin Rheumatol, 20.5 (2006): 1003-25 Grimble RF. “Nutritional antioxidants and the modulation of inflammation: theory and practice,” New Horiz. 1994 May;2(2):175-85. Hellsten Y, Skadhauge L, Bangsbo J. “Effect of ribose supplementation on resynthesis of adenine nucleotides after intense intermittent training in humans,” Am J Physiol Regul Integr Comp Physiol. 2004 Jan: 286 (1): R 182-8. Hogan, P.G., “Transcriptional regulation by calcium, calcineurin, and NFAT,” Genes and Dev.. 17. (2003): 2205-2232 Kakkar P, Singh BK. “Mitochondria: a hub of redox activities and cellular distress control,” Mol Cell Biochem. 2007 Nov;305(1-2):235-53. Epub 2007 Jun 12. Karin M, Lin A. “NF-kappa.B at the crossroads of life and death,” Nature Immunology (2002), 3(3), 221-227. CHAPTER 1 304 Bibliography Kumar A, Takada Y, Boriek AM, Aggarwal BB. “Nuclear factor-kappaB: its role in health and disease,” J Mol Med. 2004 Jul;82(7):434-48.

Kumar, D. “Transcriptional synergy mediated by SAF-1 and AP-1: critical role of N-terminal polyalanine and two zinc finger domains of SAF-1,” J Biol Chem 284.3 (2009): 1853-62 Kundu JK, Surh YJ. “Inflammation: gearing the journey to cancer,” Mutat Res. 2008 Jul-Aug;659(1-2):15-30. Li Q, Withoff S, Verma IM. “Inflammation-associated cancer: NF-kappaB is the lynchpin,” Trends Immunol. 2005 Jun;26(6):318-25. Mantovani A, Marchesi F, Porta C, Sica A, Allavena P. “Inflammation and cancer: breast cancer as a prototype,” Breast. 2007 Dec;16 Suppl 2:S27-33. Martel-Pelletier, Pelletier JP. “Is osteoarthritis a disease involving only cartilage or other articular tissues?” Eklem Hastalik Cerrahisi. 2010 Apr;21(1):2-14. MCcAnn SM, Mastronardi C, de Laurentiis A., Rettori V. “The Nitric Oxide Theory of Aging Revisited,” Ann NY Acad Sci. 2005 Dec;1057:64-84. Neelands PJ, Clandinin MT. “Diet fat influences liver plasma membrane lipid composition and glucagon-stimulated adenylate cyclase activity,” Biochem J. 1983: (212): 573-583. Ottestad I, Hassani S, Borge GI, Kohler A, Vogt G, Hyo tyla inen T, Ores ic M, Brønner KW, Holven KB, Ulven SM, Myhrstad MC. “Fish Oil Supplementation Alters the Plasma Lipidomic Profile and Increases Long-Chain PUFAs of Phospholipids and Triglycerides in Healthy Subjects,” PLoS One. 2012;7(8):e42550. Epub 2012 Aug 28. Porta C, Larghi P, Rimoldi M, Totaro MG, Allavena P, Mantovani A, Sica A. “Cellular and molecular pathways linking inflammation and cancer,” Immunobiology. 2009 214(9-10):761-77. Rao, A. “Transcription factors of the NFAT family: regulation and function,” Annu Rev Immuno;.. 15. (1997): 707-47. Ray, A. “An inflammation-responsive transcription factor in the pathophysiology of osteo- arthritis,” Biorheology. 45.3-4 (2008): 399-409. Rodova, M. “Nfat1 regulates adult articular chodrocyte function through its age-dependent expression mediated by epigenetic histone methylation,” J Bone Miner Res. 26.8 (2011): 1974-86. Schroeppel, JP. "Molecular regulation of articular chondrocyte function and its significance in osteoarthritis." Histol Histopathol. 26.3 (2011): 377-94. Sen R, Baltimore D. 1986a. “Multiple nuclear factors interact with the immunoglobulin enhancer sequences,” Cell 46: 705–716. Sica A, Allavena P, Mantovani A. “Cancer related inflammation: the macrophage connec- tion,” Cancer Lett. 2008 Aug 28;267(2):204-15. Sikora E, Bielak-Zmijewska A, Mosieniak G, Piwocka K. “The promise of slow down ageing may come from curcumin,” Curr Pharm Des. 2010;16(7):884-92. Sikora E, Scapagnini G, Barbagallo M. Curcumin, “Inflammation, ageing and age-related diseases,” Immun Ageing. 2010 Jan 17;7(1):1. Sirhan C N, Arita M, Hong S and Gotlinger K. “Resolvins, Docosatrienesx, and Neuroprotectins, Novel Omega-3-Derived Mediators, and Their Endogenous Aspirin- Triggered Epimers,” Lipids. 2004 39 (11) 1125-1132. Solinas G, Germano G, Mantovani A, Allavena P. “Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation,” J Leukoc Biol. 2009 Nov;86(5):1065-73.

Tchetina, EV. “Developmental mechanisms in articular cartilage degradation in osteoar- thritis,” Arthritis Res Ther. (2011): Valen G, Yan ZQ, Hansson GK. “Nuclear factor kappa-B and the heart,” J Am Coll Cardiol. 2001 Aug;38(2):307-14. Wang J, Gardner BM, Lu Q, Rodova M, Woodbury BG, Yost JG, Roby KF, Pinson DM, Tawfik O, Anderson HC. “Transcription factor Nfat1 deficiency causes osteoarthritis through dysfunction of adult articular chondrocytes,” J Pathol. 2009 Oct;219(2):163-72. Wu, Y, Zhou BP. “Inflammation: a driving force speeds cancer metastasis,” Cell Cyle. 2009 Oct 15;8(20):3267-73. Yudoh K, Trieu N, Nakamura H, Hongo-Masuko K, Kato T and Nishioka K. “Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation ofchondro- cyte function,” Arthritis Res Ther 2005, 7:R380-R391 CHAPTER 2 Joints: How they Work and What Can Go Wrong Abramson SB, Attur M. “Developments in the scientific understanding of osteoarthritis,” Arthritis Res Ther. 2009;11(3):227. Aigner T, Kim HA. “Apoptosis and cellular vitality: issues in osteoarthritis human articular cartilage,” Ann Rheum Dis. 2000 59:959-965. Akhtar, N. “Epigallocaatechin-3-gallate supresses the global interleukin-1-beta-induced inflammatory response in human chondrocytes,” Arthritis Res Ter. 13.3 (2011): R93. Print. <PID 21682898>. Akiyama H, Chaboissier MC, Martin JF, Schedl A, de Cruombrugghe B. “The transcrip- tion factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6,” Genes Dev. 2002, 16: 2813-2828. Akiyama H, Lyons JP, Mori-Akiyama Y, Yang X, Zhang R, Zhang Z, Deng JM, Taketo MM, Nakamura T, Behringer RR, McCrea PD, de Crombrugghe B. “Interactions between Sox9 and beta-catenin control chondrocyte differentiation,” Genes Dev. 2004 May 1;18(9):1072-87. Bibliography 305 306 Bibliography Almonte-Becceril M, Navarro-Garcia F, Gonzalez-Robles A, Vega-Lopez MA, Lavalle C, Kouri JB. “Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model,” Apoptosis. 2010 May;15(5):631-8. Amano K, Hata K, Sugita A, Takigawa Y, Ono K, Wakabayashi M, Kogo M, Nishimura R, Yoneda T. “Sox9 family members negatively regulate maturation and calcification of chondrocytes through up-regulation of parathyroid hormone-related protein,” Mol Biol Cell. 2009 Nov;20(21):4541-51. Appleton CT, Usmani SE, Bernier SM, Aigner T, Beier F. “Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis,” Arthritis Rheum. 2007 Nov;56(11):3693-705.

Attur M, Samuels J, Krasnokutsky S, Abramson SB. “Targeting the synovial tissue for treating osteoarthritis (OA): where is the evidence?” Best Pract Res Clin Rheumatol. 2010 Feb;24(1):71-9. Bianco FJ, Guitian R, Moreno J, de Toro FJ, Galdo F. “Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes,” J Rheumatol. 1999 26:1366-1373. Borzi RM, Mazzetti I, Marcu KB, Facchini A. “Chemokines in Cartlage Degradation,” Clin Ortho and Related Research. 2004 Number 427S, pp. S53-S61. Checker, R. “Potent anti-inflammatory activity of ursolic acid, a triterpenoid antioxidant, is mediated through suppression of NF-KB, AP-1 and NF- AT,” PLoS One. 7.2 (2012): e31318. Print. Carter DR, Beaupre GS, Wong M, Smith RL, Andriacchi, TP, Schurman, DJ. “The Mechanobiology of Articular Cartilage Development and Degeneration,” Clin Ortho and Related Research. No. 427S, pp. S69-S77. DeGroot J. “The AGE of the matrix: chemistry, consequence, and cure,” Curr Opin Pharmacol. 2004 Jun;4(3):301-5. Del Carlo M Jr, Loeser RF. “Cell death in osteoarthritis,” Curr Rheumatol Rep. 2008 Jan;1(1):37-42. Duchene J, Lecomete, F Ahmed S, Cayla C, Pesquero J, Bader M, Peretti M, Ahluwalia A. “A Novel Inflammatory Pathway Involved in Leukocyte Recruitment: Role for the Kinin B1 Receptor and the Chemokine CXCL5,” The J of Immun, 2007, 179, 4849-4856. Eyre, DR. “Collagens and Cartilage Matrix Homeostasis,” Clin Ortho and Related Research. 2004 No. 427S, pp. S118-S122. Fernandes JC, Martel-Pelletier J, Pelletier JP. “The role of cytokines in osteoarthritis patho- physiology,” Biorheology. 2002;39(1-2):237-46. Fulcher GR, Hukins DWL, Shepherd DET. “Viscoelastic properties of bovine articular car- tilage attached to subchondral bone at high frequencies,” BMC Musculoskeleta Disord. 2009; 10:61. Gannon AR, Nagel T, Kelly DJ. “The role of the superficial region in determining the dynamic properties of articular cartilage,” Osteoarthritis Cartilage. 2012 Aug 10. [Epub ahead of print] Goldring, MB. “Update on the biology of the chondrocyte and the new approaches to treating cartilage diseases.” Best Pract Res Clin Rheumatol. 20.5 (2006): 1003-25. Print Goldring MB., Berenbaum, Francis. “The Regulation of Chondrocyte Function by Proinflammatory Mediators,” Clin Ortho and Related Research. 2004 Number 427S, pp. S37-S46. Goldring MB,Marcu KB. “Cartilage homeostasis in health and rheumatic diseases,” Arthritis Res Ther. 2009;11(3):224. Goldring SR, Goldring MB. “The Role of Cytokines in Cartilage Matrix Degeneration in Osteoarthritis”. Clin Ortho and Related Research. 2004 Number 427S, pp. S27-S36. Han Y, Lefebvre V. “L-Sox5 and Sox6 drive expression of the aggrecan gene in carti- lage by securing binding of Sox9 to a far-upstream enhancer,” Mol Cell Biol. 2008 Aug;28(16):4999-5013.

Hashimoto M, Nakasa T, Hikata T, Asahara H. “Molecular network of cartilage homeostasis and osteoarthritis,” Med Res Rev. 2008 May;28(3):464-81. Hashimoto S, Ochs RL, Komiya S, Lotz M. “Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis,” Arthritis Rheum. 1998 41:1632-1638. Hogan, P. G. “Transcriptional regulation by calcium, calcineurin, and NFAT.,” Genes and Dev.. 17. (2003): 2205-2232. Print Ikeda T, Kamekura S, Maburchi A, Kou I, Seki S, Takato T, Nakamura K, Kawaguchi H, Ikegawa S, Chung UI. “The combination of SOX5, SOX6, and SOX9 (the SOX trio) pro- vides signals sufficient for induction of permanent cartilage,” Arthritis Rheum. 2004 Nov;50(11):3561-73. Jerosch, JP. “Effects of glucosamine and chondroitin sulfate on cartilage metabolism on OA: Outlook on other nutrient Partners especially Omega-3 fatty acids,” Int J Rheumatol. (2011): 969012. Web. 25 Jul. 2012. <PMID21826146>. Johnson EO, Charchandi A, Babis GC, Soucacos PN. “Apoptosis in osteoarthritis: mor- phology, mechanisms, and potential means for therapeutic intervention,” J Surg Orthop Adv. 2008 Fall;17(3):147-52. Katiyar, SK. “Green tea: a new option for the prevention or control of osteoarthritis,” Arthritis Res Ther. 13.4 (2011): 121. Print. <PMID 21861859>. Kevorkian L, Young DA, Darrah C, Donell ST, Shepstone L, Porter S, Brockbank SM, Edwards DR, Parker AE, Clark IM. “Expression profiling of metalloproteinases and their inhibitors in cartilage,” Arthritis Rheum. 2004 Jan;50(1):131-41. Bibliography 307 Kim W, Thambyah A, Broom N. “Does prior sustained compression make cartilage-on- bone more vulnerable to trauma?” Clin Biomech (Bristol, Avon). 2012 Aug;27(7):637-45. Epub 2012 Apr 24. Kumar, D. “Transcriptional synergy mediated by SAF-1 and AP-1: critical role of N-terminal polyalanine and two zinc finger domains of SAF-1,” J Biol Chem.. 284.3 (2009): 1853-62.. Print. Knudson CB, Knudson W. “Hyaluronan and CD44 – Modulators of Chondrocyte Metabolism,” Clin Ortho and Related Research. 2004 Number 427S, pp. S152-S162. Lee JH, Fitzgerald JB, DiMicco MA, Cheng DM, Flannery CR, Sandy JD, Plaas AH, Gordzinsky AJ. “Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production,” Arch Biochem Biophys. 2009 Sep;489(1-2):118-26. Epub 2009 Jul 14. Liacini A, Sylvester J, Li WQ, Zafarullah M. “Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondro- cytes,” Matrix Biol. 2002 Apr;21(3):251-62. Liacini A, Sylvester J, Li WQ, Huang W, Dehnade F, Ahmad M, Zafarullah M. “Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes,” Exp Cell Res. 2003 Aug 1;288(1):208-17. Loeser RF Jr. “Aging cartilage and osteoarthritis—what’s the link?” Sci Aging Knowledge Environ. 2004 Jul 21;2004(29):pe31.

Loeser RF Jr. “Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix,” Osteoarthritis Cartilage. 2009 Aug;17(8):971-9. Lopez-Armada MJ, Carames B, Martin MA, Cillero-Pastor B, Lires-Dean M, Fuentes- Boquete I, Arenas J. Bianco, FJ. “Mitochondrial activity is modulated by TNFalpha and IL-1beta in normal human chondrocyte cells,” Osteoarthritis Cartilage. 2006 Oct;14(10):1011- 22. Epub 2006 May 5. Malemud, CJ. “Protein Kinases in Chondrocyte Signaling and Osteoarthritis,” Clin Ortho and Related Research. 2004 Number 427S, pp. S145-S151. Malemud, CJ. “Anticytokine therapy for osteoarthritis: evidence to date,” Drugs Aging. 27.2 (2010): 95-115. Print. Marcu KB, Otero M, Olivotto E, Borzi RM, Goldring MB. “NF-kappaB signaling: multiple angles to target OA,” Curr Drug Targets. 2010 May; 11(5):599-613. Martel-Pelletier J. “Pathophysiology of osteoarthritis,” Osteoarthr Cartil 1998, 6:374-376. Martel-Pelletier J, Pelletier JP. “Is osteoarthritis a disease involving only cartilage or other articular tissues?” Eklem Hastalik Cerrahisi. 2010 Apr;21(1):2-14. McKinley, TO, Rudert MJ, Koos, DC, Tochigi Y, Baer TE, Brown TD. “Pathomechanic Determinants of Posttraumatic Arthritis,” Clin Ortho and Related. 2004 Research. No. 427S, pp. S78-S88. Mix KS, Sporn MB, Brinckerhoff CE. “Novel Inhibitors of Matrix Metalloproteinase Gene Expression as Potential Therapies for Arthritis,” Clin Ortho and Related Research 2004 Number 427S, pp. S129-S137. Moreno-Rubio J, Herrero-Beaumont G, Tardio L, Alvarez-Soria MA, Largo R. “Nonsteroidal antiinflammatory drugs and prostaglandin E92) modulate the synthesis of osteoprotegerin and RANKL in the cartilage of patients with severe knee osteoarthritis,” Arthritis Rheum. 2010 Feb;62(2):478-88. Nah SS, Choi IY, Lee CK, Oh JS, Kim YG, Moon HB, Yoo B. “Effects of advanced glycation end products on the expression of COX-2, PGE2 and NO in human osteoarthritic chon- drocytes,” Rheumatology (Oxford). 2008 Apr;47(4):425-31. Okada A, Okada Y. “Progress of research in osteoarthritis. Metalloproteinases in osteo- arthritis,” Clin Calcium. 2009 Nov;19(11):1953-601. Okazaki K, Sandell LJ. “Extracellular Matrix Gene Regulation,” Clin Ortho and Related Research. 2004 Number 427S, pp. S123-S128. Orrenius S. “Reactive oxygen species in mitochondria-mediated cell death,” Drug Metab Rev. 2007;39(2-3):443-55. Orrenius S, Gogvadze V, Zhivotovsky B. “Mitochondrial oxidative stress: implications for cell death,” Annu Rev Pharmacol Toxicol.2007;47:143-83. Pelletier JP, Fernandes JC, Jovanovic DV, Reboul P, Martel-Pelletier J. “Chondrocyte death in experimental osteoarthritis is mediated by MEK1/2 and p38 pathways: role of cyclo- oxygenase-2 and inducible nitric oxide synthase,” J Rheumatol 2001, 28:2509-2519. Rao, A. “Transcription factors of the NFAT family: regulation and function,” Annu Rev Immuno;.. 15. (1997): 707-47. Print.

Ray, A. “An inflammation-responsive transcription factor in the pathophysiology of osteo- arthritis,” Biorheology. 45.3-4 (2008): 399-409. Print. Revell P.A. “Synovial lining cells,” Rheumatology International, Vol 9, No 2 (1989), 49-51. Rodova, M. “Nfat1 regulates adult articular chodrocyte function through its age-dependent expression mediated by epigenetic histone methylation,” J Bone Miner Res. 26.8 (2011): 1974-86. Print Roman-Blas JA, Jimenez SA. “NF-kB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis,” OsteoArthritis and Cartilage 2006 14,839-848. Roos H, Adalberth T, Dahlberg L, Lohmander LS. “Osteoarthritis of the knee after injury to the anterior cruciate ligament or meniscus: the influence of time and age,” Osteoarthritis Cartilage. 1995 Dec;3(4):261-7. 310 Bibliography Salter RB. “The biologic concept of continuous passive motion of synovial joints. The first 18 years of basic research and its clinical application,” Clin Orthop Relat Res. 1989 May;(242):12-25. Schroeppel, JP. “Molecular regulation of articular chondrocyte function and its significance in osteoarthritis,” Histol Histopathol. 26.3 (2011): 377-94. Print Smith RL, Carter DR, Schurman DJ. “Pressure and shear differentially alter human articular chondrocyte metabolism: a review,” Clin Orthop Relat Res. 2004 Oct;(427 Suppl):S89-95. Schurman DJ, Smith RL. “Osteoarthritis – Current Treatment and Future Prospects for Surgical, Medical, and Biologic Intervention,” Clin Ortho and Related Research 2004, No. 427S,pp. S183-S189. Seguin CA, Bernier SM. “TNFalpha suppresses link protein and type II collagen expres- sion in chondrocytes: Role of MEK1/2 and NF-kappaB signaling pathways,” J. Cell Physiol. 2003 Dec;197(3):356-69. Shakibaei M, Schulze-Tanzil G, de Souza P, John T, Rahmanzadeh M, Rahmanzedeh R, Merker HJ. “Inhibition of mitogen-activated protein kinase kinase induces apoptosis of human chondrocytes,” J Biol Chem. 2001 Apr 20;276(16):13289-94. Sharma A, Wood LD, Richardson JB, Roberts S, Kuiper NJ. “Glycosaminoglycan profiles of repair tissue formed following chondrocyte implantation differ from control cartilage,” Arthritis Research & Therapy. 2007, 9:R79. Smith RL, Carter DR, Schurman DJ. “Pressure and Shear Differentially Alter Human Articular Chondrocyte Metabolism,” Clin Ortho and Related Research 2004 No.427S, pp. S89-S95. Sutton S, Clutterbuck A, Harris P, Gent T, Freeman S, Foster N, Barrett-Jolley R, Mobasheri A. “The contribution of the synovium, synovial derived inflammatory cytokines and neu- ropeptides to the pathogenesis of osteoarthritis,” Vet J. 2009 Jan;179(1):10-24. Terkeltaub R, Johnson K, Murphy A, Ghosh S. “Invited review: the mitochondrion in osteo- arthritis,” Mitochondrion 2002, 1:301-319. Tchetina, EV. “Developmental mechanisms in articular cartilage degradation in osteoar- thritis,” Arthritis Res Ther. (2011): 683970. Print.

Uzel SG, Buehler MJ. “Molecular structure, mechanical behavior and failure mechanism of the C-terminal cross-link domain in type I collagen,” J Mech Behav Biomed Mater. 2011 Feb;4(2):153-61. Epub 2010 Jul 16. Verzijl N, Bank RA, TeKoppele JM, DeGroot J. “AGEing and osteoarthritis: a different perspective,” Curr Opin Rheumatol. 2003 Sep;15(5):616-22. Verzijl N, DeGroot J, Ben ZC, Brau-Genjamin O, Maroudas A, Bank RA, Mizrahi J, Schalkwijk CG, Thorpe SR, Bay__ JW, Bijlsma JW, Lafeber FP, TeKoppele JM. “Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for osteoarthritis,” Arthritis Rheum. 2002 Jan;46(1):114-23. Walsh DA, Bonnet CS, Turner EL, Wilson D, Situ M, McWilliams DF. “Angiogenesis in the synovium and at the osteochondral junction in osteoarthritis,” Osteoarthritis Cartilage. 2007 Jul;15(7):743-51. Wang, J. “Transcriptional factor Nfat1 deficiency causes osteoarthritis through dysfunction of the adult articular chondrocytes,” J Pathol. 19.2 (2009): 163-72. Print Wang J, Gardner BM, Lu Q, Rodova M, Woodbury BG, Yost JG, Roby KF, Pinson DM, Tawfik O, Anderson HC. “Transcription factor Nfat1 deficiency causes osteoarthritis through dysfunction of adult articular chondrocytes,” J Pathol. 2009 Oct;219(2):163-72. Yasuda T, Nakamura T. “Inhibition of nuclear factor-kappaB by hyaluronan in rheumatoid chondrocytes stimulated with COOH-terminal heparin-binding fibronectin fragment,” Mod Rheumatol. 2007;17(5):391-7. Yasuhara, R, Miyamotot Y, Akaike T, Akuta T, Nakamura M, Takami M, Morimura N, Yasu K, Kamijo R. “Interleukin-1B induces death in chondrocyte-like ATDC5 cells through mito- chondrial dysfunction and energy depletion in a reactive mitrogen and oxygen species- dependent manner,” Biochem J. 2005,389:315-323. Yudoh, K. “Potential involvement of oxidative stress in cartilage senescence and develop- ment of osteoaarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function,” Arthritis Res Ther. 7.2 (2005): 380-91. Print CHAPTER 3 Eat: Foods that Reduce Joint Pain Aggarwal BB, Shishodia S. “Molecular targets of dietary agents for prevention and therapy of cancer,” Biochem Pharmacol. 2006 71:1397-1421 Akhtar, N. “Epigallocaatechin-3-gallate suppresses the golobal interleukin-1-beta-induced inflammatory response in human chondrocytes,” Arthritis Res Ter. 13.3 (2011):R93 Aktan F, Henness S, Tran VH, Duke CC, Roufogalis BD, Ammit AJ. “Gingerol metabolite and a synthetic analogue Capsarol inhibit macrophage NF-kappaB-mediated iNOS gene expression and enzyme activity,” Planta Med. 2006 Jun;72(8):727-34. Atkins RC. Dr. Atkins’ New Diet Revolution. Avon Health, 1992. Atkins RC. Dr Atkins’ Age-defying Diet Revolution. St. Martin’s Press, 1999 Atkins RC. Atkins for Life. St. Martin’s Press, 2003

Auvichayapat P, Prapochanung M, Tunkamnerdthai O, Sripanidkulchai BO, Auvichayapat N, Thinkhamrop B, Kunhasura S, Wongpratoom S, Sinawat S. Hongprapas P. “Effectiveness of green tea on weight reduction in obese Thais: A randomized, controlled trial,” Physiol Behav. 2008 Feb 27;93(3):486-91. Aviello G, Abenavoli L, Borrelli F, Capasso R, Izzo AA, Lembo F, Romano B, Capasso F. “Garlic: empiricism or science?” Nat Prod Commun. 2009 Dec;4(12):1785-96. Bibliography 311 312 Bibliography Bagga D, Wang L, Farias-Eisner R, Glaspy JA, and Reddy ST. “Differential effects of pros- taglandin derived from Omega 6 and Omega 3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion,” PNAS Feb 18, 2003 100(4) 1751-56. Barclay AW, Petocz P, McMillan-Price J, Flood VM, Prvan T, Mitchell P, Brand-Miller JC. “Glycemic index, glycemic load, and chronic disease risk--a meta-analysis of observational studies,” Am J Clin Nutr. 2008 Mar;87(3):627-37. Bellido C, Lopez-Miranda J, Blanco-Colio LM, Perez-Martinez P, Muriana FJ, Martin- Ventura JL, Marin C, Gomez P, Fuentes F, Egido J, Perez-Jiminez F. “Butter and walnuts, but not olive oil, elicit postprandial activation of nuclear transcription factor kappaB in periph- eral blood mononuclear cells from health men,” Am J Clin Nutr. 2004 Dec;80(6):1487-91. Bendsen NT, Stender S, Szecsi PB, Pedersen SB, Basu S, Hellgren LI, Newman JW, Larsen TM, Haugaard SB, Astrup A. “Effect of industrially produced trans fat on markers of systemic inflammation: evidence from a randomized trial in women,” J Lipid Res. 2011 Oct;52(10):1821-8. Epub 2011 Jul 27. Binukumar B, Mathew A. “Dietary fat and risk of breast cancer,” World J of Surg Onc 2005 3:45. Borrelli F, Capasso R, Izzo AA. Garlic (Allium sativum L.): “Adverse effects and drug interactions in humans,” Mol Nutr Food Res. 2007 Nov;51(11):1386-97. Botolin D, Wang Y, Christian B, Jump DB. “Docosahexaenoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent path- ways” J Lipid Res. 2006 Jan;47(1):181-92. Bourre JM. “Dietary omega-3 fatty acids for women,” Biomed Pharmacother. 2007 Feb-Apri;61(2-3):105-12. Bourre JM. “Effect of increasing the omega-3 fatty acid in the diets of animals on the animal products consumed by humans,” Med Sci(Paris). 2005 Aug-Sep;21(8-9):773-9. Bowden J. Living The Low Carb Life. Sterling Publishing, 2004. Brace LD. “Cardiovascular benefits of garlic (Allium sativum L),” J Cardiovasc Nurs. 2002 Jul;16(4):33-49. Carlsen H, Haugen F, Zadelaar S, Kleemann R, Kooistra T, Drevon CA, Blomhoff R. “Diet- induced obesity increases NF-kappaB signaling in reporter mice,” Genes Nutr. 2009 Sep;4(3):215-22. Cao JJ, Nielsen. “Acid Diet (High-Meat Protein) Effects on Calcium Metabolism and Bone Health- Research Review,” Curr Opin Clin Nutr Metab Care. 2010 Aug 16.

Chatsudthipong, V.; Muanprasat, C. (). “Stevioside and related compounds: therapeutic benefits beyond sweetness,” Pharmacol Ther . Jan 2009 Jan 121 (1): 41–54. Checker, R. “Potent anti-inflammatory activity of ursolic acid, a triterpenoid antioxidant is mediated through suppression of NFKB, AP-1 and Nfat,” PLos One. 7.2 (2012): e31318 Daley CA, Abbott A, Doyle PS, Nader GA, Larson S. “A review of fatty acid profiles and antioxidant content in grass-fed and grain-fed beef” Nutr Journ 2010 9:10. Devi Sampath P, Vijayaraghavan K. “Cardioprotective effect of alpha-mangostin, a xan- thone derivative from mangosteen on tissue defense system against isoproterenol-induced myocardial infarction in rats,” J. Biochem Mol Toxicol. 2007;21(6):336-9. Drozdowski LA, Dixon WT, McBurney MI, Thomson AB. “Short-chain fatty acids and total parenteral nutrition affect intestinal gene expression,” JPEN J Parenter Enteral Nutr. 2002 May-Jun;26(3):145-50. Dulloo AG, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M, Chantre P, Vandermander J. “Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans,” Am J Clin Nutr. 1999 Dec;70(6):1040-5. Eades, MR, Eades, MD. The Protein Power Lifeplan. Warner Books, 2000, Erkkilä AT, Lichtenstein AH. Fiber and cardiovascular disease risk: how strong is the evi- dence? J Cardiovasc Nurs. 2006 Jan-Feb;21(1):3-8. Fernandez ML, West KL. “Mechanisms by which Dietary Fatty Acids modulate Plasma Lipids,” The Amer Soc for Nutr Sciences J Nutr. 2005 Sep 135:2075-2078. Fuehrlein BS, Rutenberg MS, Silver JN, Warren MW, Theriaque DW, Duncan GE, Stacpoole PW, Brantly ML. “Differential metabolic effects of saturated versus polyunsaturated fats in ketogenic diets,” Clin Endoc & Metab. 2004 89(4):1641-1645. Gebauer SK, Psota TL, Harris WS, Kris-Etherton PM. “N-3 fatty acid dietary recommen- dations and food sources to achieve essentiality and cardiovascular benefits,” Am J Clin Nutr. 2006 Jun;83(6 Suppl):1526S-1535S. Harbige LS. “Fatty acids, the immune response, and autoimmunity: a question of n-6 essentiality and the balance between n-6 and n-3” Lipids. 2003 Apr;38(4):323-41. Hasan N, Siddiqui MU, Toossi Z, Khan S, Iqbal J, Islam N. “Allicin-induced suppression of Mycobacterium tuberculosis 85B mRNA in human monocytes,” Biochem Biophys Res Commun. 2007 Apr 6;355(2):471-6. Hernandez T and Coulson RA. “The effect of insulin on amino acid metabolism,” Biochem J. 1961 June; 79(3): 596–605. Hooper L, Kroon PA, Rimm EB, Cohn JS, Harvey I, Le Cornu KA, Ryder JJ, Hall WL, Cassidy A. “Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of random- ized controlled trials,” Am J Clin Nutr. 2008 Jul;88(1):38-50. Hu FB. “Are refined carbohydrates worse than saturated fat?” Am J Clin Nutr. 2010 Jun 1; 91(6):1541-1542.

Hu FB, Stampfer MJ, Manson JE, Rimm E, Colditz GA, Rosner BA, Hennekens CH, Willett WC. “Dietary fat intake and the risk of coronary heart disease in women,” N Engl J Med. 1997 Nov 2;337(21):1491-9. Bibliography 313 314 Bibliography Hung SH, Shen KH, Wu CH, Liu CL, Shih YW. “Alpha-mangostin suppresses PC-3 human prostate carcinoma cell metastasis by inhibiting matrix metalloproteinase-2/9 and uro- kinase-plasminogen expression through the JNK signaling pathway,” J Agric Food Chem. 2009 Feb 25;54(4):1291-8. Hunter JE, Zhang J, Kris-Etherton PM. “Cardiovascular disease risk of dietary stearic acid compared with trans, other saturated, and unsaturated fatty acids: a systematic review,” Am J Clin Nutr. 2010 Jan;91(1):46-63. Inzucchi SE, Sherwin RS. “Type 1 diabetes mellitus,” In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, PA: Saunders Elsevier; 2011:chap 236. Ishiguro K, Anto T, Maeda O, Ohmiya N. Niwa Y, Kadomatsu K, Goto H. “Ginger ingre- dients reduce viability of gastric cancer cells via distinct mechanisms,” Biochem Biophys Res Commun. 2007 Oct 12;362(1):218-23. Iwasaki Y, Kambayashi M, Asai M, Yoshida M, Nigawara T, Hashimoto K. “High glucose alone, as well as in combination with proinflammatory cytokines, stimulates nuclear factor kappa-B-mediated transcription in hepatocytes in vitro,” J Diabetes Complications. 2007 Jan-Feb; 21(1):56-62. Jakobsen MU, Dethlefsen C, Joensen AM, Stegger J, Tjonneland A, Schmidt EB, Overvad K. “Intake of carbohydrates compared with intake of saturated fatty acids and risk of myocardial infarction: importance of the glycemic index,” Am J Clin Nutr 2010 Jun 1;91(6):1764-1768. Jakobsen MU, O’Reilly EJ, Heitmann BL, Pereira MA, Balter K, Fraser GE, Goldbourt U, Hallmans G, Knekt P, Liu S, Pietinen P, Spiegelman D, Stevens J, Virtamo J, Willett WC, Ascherio A. “Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies. Am J Clin Nutr 2009 Feb 11; 89:14-25-1432. Jenkins DJA, Wong JMW, Kendall CWC, Esfahani A, Ng VWY, Leong TCK, Faulkner DA, Vidgen E, Greaves KA, Paul G, etal. “The Effects of a Plant-Based Low-Carbohydrate(“Eco- Atkins”) Diet on Body Weight and Blood Lipid Concentrations in Hyperlipidemic Subjects,” Arch Intern Med, June 8, 2009; 169(11):1046-1054. Jia Y, Turek JJ. “Altered NF-kappaB gene expression and collagen formation induced by polyunsaturated fatty acids,” J Nutr Biochem. 2005 Aug;16(8):500-6. Jimenez-Gomez Y, Lopez-Miranda J, Blanco-Colio LM, Marin C, Perez-Martinez P, Ruano J, Paniagua JA, Rodriguez F, Egido J, Perez-Jimenez F. “Olive oil and walnut breakfasts reduce the postprandial inflammatory response in mononuclear cells compared with a butter breakfast in healthy men,” Atherosclerosis. 2009 Jun;204(2):e70-6. Julius U. “Fat modification in the diabetes diet,” Exp Clin Endocrinol Diabetes. 2003 Apr;111(2):60-5. Kadotani A, Tsuchiya Y, Hatakeyama H, Katagiri H. Kanzaki M. “Different impacts of saturated and unsaturated free fatty acids on COX-2 expression C2C12 myotubes,” Am J Physiol Endocrinol Metab 2009 297:E1291-E1303.

Kanner J. “Dietary advanced lipid oxidation endproducts are risk factors to human health,” Mol Nutr Food Res. 2007 Sep;51(9):1094-101. Katan M. “Omega-6 polyunsaturated fatty acids and coronary heart disease,” Am J Clin Nutr. 2009 May 1;89(5):1283-1284. Katiyar, SK. “Green tea a new option for the prevention or control of osteoarthritis,” Arthritis Res Ther. 13.4 (2011): 121 Kidd PM. Bioavailability and activity of phytosome complexes from botanical polyphe- nols: the silymarin, curcumin, green tea, and grape seed extracts. Altern Med Rev. 2009 Sep;14(3):226-46. Kim DH, Kim CH, Kim MS, Kim JY, Jung KJ, Chung JH, An WG, Lee JW, Yu BP, Chung HY. “Suppression of age-related inflammatory NF-kappaB activation by cinnamaldehyde,” Biogerontology. 2007 Oct;8(5):545-54. Kim EHJ, Willett WC, Colditz GA, Hankinson SE, Stampfer MJ, Hunter DJ, Rosner B, and Holmes MD. “Dietary Fat and Risk of Postmenopausal Breast Cancer in a 20-year follow up,” Am J Epidemiol. November 15, 2006; 164(10):990-997. Kim H, Bartley GE, Young SA, Davis PA, Yokoyama W. “HPMC supplementation reduces abdominal fat content, intestinal permeability, inflammation, and insulin resistance in diet-induced obese mice,” Mol Nutr Food Res. 2012 Sep;56(9):1464-76. doi:10.1002/ mnfr.201200082. Epub 2012 Jul 11. Kris-Etherton PM, Grieger JA, Etherton TD. “Dietary reference intakes for DHA and EPA,” Prostaglandins Leukot Essent Fatty Acids. 2009 Aug-Sep;81(2-3):99-104. Kromhout D, Menotti A, Bloemberg B, Aravanis C, Blackburn H, Buzina R, Dontas AS, Fidanza F, Giampaoli S, Jansen A, et al. “Dietary saturated and trans fatty acids and cho- lesterol and 25-year mortality from coronary heart disease: the Seven Countries Study,” Prev Med. 1995 May;24(3):308-15. Lakshmanan MR, Nepokroeff CM, Ness GC, Dugan RE, Porter JW. “Stimulation by insulin of rat liver β-hydroxy-β-methylglutaryl coenzyme A reductase and cholesterol-synthe- sizing activities,” Biochemical and Biophysical Research Communications Volume 50, Issue 3, 5 February 1973, Pages 704–710. Lee CH, Lum JHK, Ng CKC, McKay J, Butt YKC,Wong MS and Lo SCL. “Pain Controlling and Cytokine-regulating Effects of Lyprinol, a Lipid Extract of Perna Canaliculus, in a Rat Adjuvant-induced Arthritis Model,” eCAM 2009 6(2):239-245. Lee J, Jung E, Kim Y, Lee J, Park J, Hong S, Hyun CG, Park D, Kim YS. “Rosmarinic acid as a downstream inhibitor of IKK-beta in TNF-alpha-induced upregulation of CCL11 and CCR3,” Br J Pharmacol. 2006 Jun;148(3):366-75. Lee KW, Kundu JK, Sim SO, Chun KS, Lee HJ, Surh YJ. “Cocoa polyphenols inhibit phor- bol ester-induced superoxide anion formation in cultured HL-60 cells and expression of cyclooxygenase-2 and activation of NJ-kappaB and MAPKs in mouse skin in vivo,” J Nutr. 2006 May;136(5):1150-5. Bibliography 315 316 Bibliography Lee SH, Lee SY, Son DJ, Lee H, Yoo HS, Song S, Oh KW, Han DC, Kwon BM, Hong JT. “Inhibitory effect of 2’-hydroxycinnamaldehyde on nitric oxide production through

inhi- bition of NF-kappa B activation in RAW 264.7 cells,” Biochem Pharmacol. 2005 Mar 1;69(5):791-9. Lee YR, Lee JH, Noh EM, Kim EK, Song MY, Jung WS, Park SJ, Kim JS, Park JW, Kwon KB, Park BH. Guggulsterone blocks IL-1beta-mediated inflammatory responses by suppressing NF-kappaB activation in fibroblast-like synoviocytes. Life Sci. 2008 Jun 6;82(23-24):1203-9. Liao BC, Hsieh CW, Liu YC, Tzeng TT, Sun YW, Wung BS. “Cinnamaldehyde inhibits the tumor necrosis factor-alpha-induced expression of cell adhesion molecules in endothelial cells by suppressing NF-kappaB activation: effects upon IKappaB and Nrf2,” Toxicol Appl Pharmacol. 2008 Jun 1;229(2):161-71. Lockwood Cm, Moon JR, Tobkin SE, Walter AA, Smith AE, Dalbo VJ, Cramer JT, Stout JR. “Minimal nutrition intervention with high-protein/low-carbohydrate and low-fat, nutrient- dense food supplement improves body composition and exercise benefits in overweight adults: A randomized controlled trial,” Nutr Metab (Lond). 2008 Apr 21;5:11. Lovegrove JA, Lovegrove SS, Lesauvage SV, Brady LM, Saini N, Minihane AM, Williams CM. “Moderate fish-oil supplementation reverses low-platelet, long-chain n-3 polyun- saturated fatty acid status and reduces plasma triacylglycerol concentrations in British Indo-Asians,” Am J Clin Nutr. 2004 Jun;79(6):974-82. Lovejoy J, Smith S, Champagne C, Most M, Lefevre M, DeLany J, Denkins Y, Rood J, Veldhuis J, and Bray G. “Effects of Diets Enriched in Saturated (Palmitic), Monounsaturated (Oleic), or trans (Elaidic) Fatty Acids on Insulin Sensitivity and Substrate Oxidation in Healthy Adults,” Diabetes Care August 2002 vol. 25 no. 8 1283-1288 Ma Y, Hébert JR, Li W, Bertone-Johnson ER, Olendzki B, Pagoto SL, Tinker L, Rosal MC, Ockene IS, Ockene JK, Griffith JA, Liu S. “Association between dietary fiber and markers of systemic inflammation in the Women’s Health Initiative Observational Study,” Nutrition. 2008 Oct;24(10):941-9. Epub 2008 Jun 18. Ma J, A Griffith J, Chasan-Taber L, C Olendzki B, Jackson E, Stanek III E, Li W, Pagoto S, Hafner, A, and Ockene I. “Association between dietary fiber and serum C-reactive pro- tein1,2,3,” Am J Clin Nutr April 2006 vol. 83 no. 4 760-766. Mensink RP, Zock PL, Kester AD, Katan MB. “Effects of dietary fatty acids and carbohy- drates on the ratio of serum total to HDL cholesterol and on serum lips and apolipoproteins: a meta-analysis of 60 controlled triglycerides,” Am J Clin Nutr. 2003 May;77(5):1146-55. Mente A, de Koning L, Shannon HS, Anand SS. “A Systematic Review of the Evidence Supporting a Causal Link Between Dietary Factors and Coronary Heart Disease,” Arch Intern Med, April 13, 2009;169(7):659-669. Mix KS, Sporn MB, Brinckerhoff CE. “Novel Inhibitors of Matrix Metalloproteinase Gene Expression as Potential Therapies for Arthritis,” Clin Ortho and Related Research 2004 Number 427S, pp. S129-S137. Mozaffarian D, Ascherio A, Hu FB, Stampfer MJ, Willett WC, Siscovick DS, Rimm EB. “Interplay between different polyunsaturated fatty acids and risk of coronary heart disease in men,” Circulation. 2005 Jan 18;111(2):157-64.

Mozaffarian D, Micha R, Wallace S. “Effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trials,” PLoS Med. 2010 Mar 23;7(3):e1000252. Murakami Y, Hirata A, Ito S, Shoji M, Tanaka S, Yasui T, Machino M, Fujisawa S. “Re-evaluation of cyclooxygenase-2-inhibiting activity of showed that in and guaia- col in macrophages stimulated with lipopolysaccharide,” Anticancer Res. 2007 Mar-Apr;27(2):801-7. Murakami Y, Hirata A, Ito S, Shoji M, Tanaka S, Yasui T, Machino M, Fujisawa S. Re-evaluation of cyclooxygenase-2-inhibiting activity of showed that in and guaiacol in macrophages stimulated with lipopolysaccharide. Anticancer Res. 2007 Mar-Apr;27(2):801-7. Nakatani K, Yamakuni T, Kondo N, Arakawa T, Oosawa K, Shimura S, Inoue H, Ohizumi Y. “Gamma-Mangostin inhibits inhibitor-kappaB kinase activity and decreases lipopolysac- charide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells,” Mol Pharmacol. 2004 Sep; 66(3):667-74. Nakatani K. “Inhibition of cyclooxygenase and prostaglandin E2 synthesis by gamma mangostin axthanone derivative in mangosteen, in C6 rat glioma cells,” Biochem Pharm 2002 63 73-79. Nemoseck T, Cole S, Petrisko Y and Kern M. “Effects of agave nectar versus sucrose on weight gain, adiposity, blood glucose, insulin and lipid responses in mice,” FASEB J. April 2010 24 (Meeting Abstract Supplement). Oh K, Hu FB, Manson JE, Stampfer MJ, Willett WC. “Dietary Fat Intake and Risk of Coronary Heart Disease in Women: 20 Years of Follow-up of the Nurses’ Health Study,” Amer. Jour of Epid. 2005 161(7):672-679. Okazaki M, Iwasaki Y, Jing H, Nishiyama M, Taguchi T, Tsugita M, Taniguchi Y, Kambayashi M, Hashimoto K. “Insulin enhancement of cytokine-induced coagulation/inflammation- related gene transcription in hepatocytes,” Endocr J. 2008 Dec;55(6):967-75. Oku T, Nakamura S. “Digestion, absorption fermentation and metabolism of functional sugar substitutes and their available energy,” Pure Appl. Chem., Vol 74. No 7, pp 1253-1261, 2002. Patha, K. “Ursolic acid inhibits STAT3 activation pathway leading to suppression of pro- liferation and chemo sensitization of human multiple myeloma cells,” Mol Can Res. 2007 Sept 5(9):943-55. Pergola C, Rossi A, Dugo P, Cuzzocrea S, Sautebin L. “Inhibition of nitric oxide biosynthesis by anthocyanin fraction of blackberry extract,” Nitric Oxide. 2006 Aug;15(1):30-9. Rai SK, Sharma M, Tiwari M. “Inhibitory effect of novel diallyldisulfide analogs on HMG- CoA reductase expression in hypercholesterolemic rats: CREB as a potential upstream target,” Life Sci. 2009 Jul 31;85(5-6):211-9. Reddy AM, Seo JH, Ryu SY, Kim YS, Kim YS, Min K, Kim Y. “Cinnamaldehyde and 2-methoxycinnamaldehyde as NF-kappaB inhibitors from Cinnamomum cassia,” Planta Med. 2004 Sep;70(9):823-7. Bibliography 317 318 Bibliography

Remig V, Franklin B, Margolis S, Kostas G, Nece T, Street JC. “Trans fats in America: a review of their use, consumption, health implications, and regulation” J Am Diet Assoc. 2010 Apr;110(4):585-92. Rimbach G, Melchin M, Moehring J, Wagner AE. “Polyphenols from cocoa and vascular health-a critical review,” Int J Mol Sci. 2009 Nov 20;10(10):4290-309. Rodriguez-Cruz M, Tovar AR, del Prado M, Torres N. “Molecular mechanisms of action and health benefits of polyunsaturated fatty acids,” Rev Invest Clin. 2005 May-Jun;57(3):457-72. Rosedale R, Westman EC, Konhilas JP. “Clinical Experience of a Diet Designed to Reduce Aging,” J Appl Res. 2009 Jan 1;9(4):159-165. Roy CC, Kien CL, Bouthillier L, Levy E. “Short-chain fatty acids: ready for prime time?” Nutr Clin Pract. 2006 Aug;21(4):351-66. Scholz-Ahrens KE, Ade P, Marten B, Weber P, Timm W, Açil Y, Glüer CC, Schrezenmeir J. “Prebiotics, probiotics, and synbiotics affect mineral absorption, bone mineral content, and bone structure,” J Nutr. 2007 Mar;137(3 Suppl 2):838S-46S. Sethi, S. “Inhibition of leukocyte-endothelial interactions by oxidized omega-3 fatty acids: a novel mechanism for the anti-inflammatory effects of omega-3 fatty acids in fish oil,” Redox Rep. 2002 7(6):369-78. Shishodia S, Majumdar S, Banerjee S, Aggarwal BB. “Ursolic acid inhibitors nuclear factor- kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1,” Cancer Res. 2003 Aug 1;63(15):4375-83. Siri-Tarino PW, Sun Q, Hu FB, Krauss RM. “Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease,” Am J Clin Nutr 2010 Mar 1;91(3):535-546. Siri-Tarino PW, Sun Q. Hu FB, Krauss RM. “Saturated fat, carbohydrate, and cardiovascular disease,” Am J of Clin Nutr. 2010 Mar 91(3):502-509. Sun Q, Ma J, Campos H, Hankinson SE, Manson JE, Stampfer MJ, Rexrode KM, Willett WC, Hu FB. “A Prospective Study of Trans Fatty Acids in Erythrocytes and Risk of Coronary Heart Disease,” Circulation, April 10, 2007; 115(14):1858-1865. Sweeney T, Collins CB, Reilly P, Pierce KM, Ryan M, O’Doherty JV. “Effect of purified β-glucans derived from Laminaria digitata, Laminaria hyperborea and Saccharomyces cerevisiae on piglet performance, selected bacterial populations, volatile fatty acids and pro-inflammatory cytokines in the gastrointestinal tract of pigs,” Br J Nutr. 2012 Feb 7:1-9. Tremblay A, Simoneau JA, Bouchard C. “Impact of exercise intensity on body fatness and skeletal muscle metabolism,” Metabolism. 1994 Jul;43(7):814-8. Thompson R. The Glycemic-Load Diet: A Powerful New Program For Losing Weight And Reversing Insulin Resistance. McGraw Hill, 2006 Van Erk MJ, Blom WA, van Ommen B, Hendriks HF. “High-protein and high-carbohydrate breakfasts differentially change the transcriptome of human blood cells,” Am J Clin Nutr. 2006 Nov;84(5):1233-41.

Virtanen JK, Mozaffarian D, Chiuve SE, Rimm EB. “Fish consumption and risk of major chronic disease in men,” Am J Clin Nutr. 2008 Dec;88(6):1618-25. Wang S, Wu D, Matthan NR, Lmon-Fava S, Lecker JL, Lichtenstein AH. “Reduction in dietary omega-6 polyunsaturated fatty acids: eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouse,” Atherosclerosis. 2009 May;204(1):147-55. Wang S, Wu D, Lamon-Fava S, Matthan NR, Honda KL, Lichtenstein AH. “In vitro fatty acid enrichment of macrophages alters inflammatory response and net cholesterol accumula- tion,” Br J Nutr. 2009 Aug;102(4):497-501. Welsh JA, Sharma A, Abramson JL, Vaccarino V, Gillespie C, Vos MB. “Caloric Sweetener Consumption and Dyslipidemia Among US Adults,” JAMA 2010 303(15):1490-1497. Welden SM, Mullen AC, Loscher CE, Hurley LA, Roche HM. “Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid,” J Nutr Biochem. 2007 apr;18(4):250-8. Wong JM, de Souza R, Kendall CW, Emam A, Jenkins DJ. “Colonic health: fermentation and short chain fatty acids,” J. Clin Gastroenterol. 2006 Mar;40(3):235-43. Xu J, Eilat-Adar S, Loria C, Goldbourt U, Howard BV, Fabsitz RR, Zephier EM, Mattil C, and Lee ET. “Dietary fat intake and risk of coronary heart disease: the Strong Heart Study,” Am J Clinical Nutrition, Oct 1, 2006;84(4):894-902. Yates A, Norwig J, Maroon J, Bost J, Bradley JP, Duca M, Wecht D, Grove R, Iso A, Cobb I, Ross N, Borden M. “Evaluation of Lipid Profiles and the Use of Omega-3 Essential Fatty Acid in Professional Football Players,” Sports Health: A Multidisciplinary Approach 2009 Jan 1;(1):21-30. Yellaturu CR, Deng X, Cagen LM, Wilcos HG, Mansbach CM, Siddiqi SA, Park EA, Raghow R, Elam MB. “Insulin Enhances Post-translational Processing of Nascent SREBP-1c by Promoting its Phosphorylation and Association with COPII vesicles,” Jour of Bio Chem. 2009 Mar 20;284:7518-7532. Yellaturu CR, Deng X, Park EA, Raghow R, Elam MB. “Insulin enhances the biogenesis of nuclear sterol regulatory element-binding protein (SREBP)-1c by posttranscriptional down-regulation of Insig-2A and its dissociation from SREBP cleavage-activating protein (SCAP).SREBP-1c complex,” J Biol Chem. 2009 Nov 13;284(46):31726-34. CHAPTER 4 Support: Supplements and Vitamins Ahmed RS, Suke SG, Seth V, Chakraborti A, Tripathi AK, Banerjee BD. Protective effects of dietary ginger (Zingiber officinales Rosc.) on lindane-induced oxidative stress in rats. Phytother Res. 2008 Jul;22(7):902-6. Ahmed RS, Seth V, Banerjee BD. Influence of dietary ginger (Zingiber officinales Rosc) on antioxidant defense system in rat: comparison with ascorbic acid. Indian J Exp Biol. 2000 Jun;38(6):604-6.

Aggarwal BB, Kumar A, Bharti AC. “Anticancer potential of curcumin: preclinical and clinical studies,” Anticancer Res 2003, 23:363-398. Bibliography 319 320 Bibliography Aggarwal BB, Shishodia S. “Molecular targets of dietary agents for prevention and therapy of cancer,” Biochem Pharmacol. 2006 71:1397-1421 Aggarwal S, Takada Y, Singh S, Myers JN, Aggarwal BB. “Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling,” Int J Cancer. 2004 111:679-692. Aktan F, Henness S, Tran VH, Duke CC, Roufogalis BD, Ammit AJ. Gingerol metabolite and a synthetic analogue Capsarol inhibit macrophage NF-kappaB-mediated iNOS gene expression and enzyme activity. Planta Med. 2006 Jun;72(8):727-34. Epub 2006 May 29. Altman RD, Marcussen KC. Effects of a ginger extract on knee pain in patients with osteoarthritis. Arthritis Rheum. 2001 Nov;44(11):2531-8. Appleton CT, Usmani SE, Bernier SM, Aigner T, Beier F. “Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis,” Arthritis Rheum. 2007 Nov;56(11):3693-705. Ashkavand Z, Malekinejad H, Amniattalab A, Rezaei-Golmisheh A, Vishwanath BS. Silymarin potentiates the anti-inflammatory effects of Celecoxib on chemically induced osteoarthritis in rats. Phytomedicine. 2012 Aug 24. Auvichayapat P, Prapochanung M, Tunkamnerdthai O, Sripanidkulchai BO, Auvichayapat N, Thinkhamrop B, Kunhasura S, Wongpratoom S, Sinawat S. Hongprapas P. Effectiveness of green tea on weight reduction in obese Thais: A randomized, controlled trial. Physiol Behav. 2008 Feb 27;93(3):486-91. Aziz MH, Afaq F, Ahmad N. “Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in surviving,” Protochem Photobiol. 2005 81:25-31. Aziz MH, Reagan-Shaw S, Wu J, Longley BJ, Ahmad N. “Chemoprevention of skin cancer by grape constituent resveratrol: relevance to human disease?” Faseb J. 2005 19:1193-1995. Bailey RL, Dodd KW, Goldman JA, Gahche JJ, Dwyer JT, Moshfegh AJ, Sempos CT, Picciano MF. Estimation of total usual calcium and vitamin D intakes in the United States. J Nutr. 2010 Apr;140(4):817-22. Epub 2010 Feb 24. Bhardwaj A, Sethi G, Vadhan-Raj S, Bueso-Ramos C, Takada Y, Guar U, Nair AS, Shishodia S, Aggarwal BB. “Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells,” Blood. 2007 109:2293-2302. Bennett C, Sinatra ST. Sugar Shock How Sweets And Simple Carbs Can Derail Your Life- And How You Can Get Back On Track. Berkley Trade, 2006. Bharti AC, Donato N, Singh S, Aggarwal BB. “Curcumin (diferuloylmethane) down-reg- ulates the constitutive activation of nuclear factor kB and IkBa kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis,” Blood 2003. 101:1053-1062.

Botolin D, Wang Y, Christian B, Jump DB. “Docosahexaenoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent path- ways,” J Lipid Res. 2006 Jan;47(1):181-92 Bremner P, Heinrich M. “Natural products as targeted modulators of the nuclear factor- kappaB pathway,” J Pharm Pharmacol. 2002 54:453-472. Caire-Juvera G, Ritenbaugh C, Wactawski-Wende J, Snetselaar LG, Chen Z. “Vitamin A and retinol intakes and the risk of fractures among participants of the Women’s Health Initiative Observational Study,” Am J Clin Nutr. 2009 Jan;89(1):323-30. Epub 2008 Dec 3. Cao JJ, Nielsen FH. Acid diet (high-meat protein) effects on calcium metabolism and bone health. Curr Opin Clin Nutr Metab Care. 2010 Nov;13(6):698-702. Cardinali DP, García AP, Cano P, Esquifino AI. Melatonin role in experimental arthritis. Curr Drug Targets Immune Endocr Metabol Disord. 2004 Mar;4(1):1-10. Carlsen H, Haugen F, Zadelaar S, Kleemann R, Kooistra T, Drevon CA, Blomhoff R. “Diet- induced obesity increases NF-kappaB signaling in reporter mice,” Genes Nutr. 2009 Sep;4(3):215-22. Chen CH, Sheu MT, Chen TF, Wang YC, Hou WC, Liu DZ, Chung TC, Liang YC. Suppression of endotoxin-induced proinflammatory responses by citrus pectin through blocking LPS signaling pathways. Biochem Pharmacol. 2006 Oct 16;72(8):1001-9. Chopra A, Lavin P, Patwardhan B, Chitre D. A 32-week randomized, Placebo-Controlled Clinical Evaluation of Ra-11, an Ayurvedic Drug, on Osteoarthritis of the Knees. J Clin Rheumatol. 2004 Oct;10(5):236-245. Csaki C, Keshishzadeh N, Fischer K, Shakibaei M. Regulation of inflammation signalling by resveratrol in human chondrocytes in vitro. Biochem Pharmacol 2008, 75:677-687. Cutolo, M. The Melatonin Cytokine Connection in Rheumatoid Arthritis. ANN Rheum Dis 2005 August 64 (8) 1109-1111. Dong Z. “Molecular mechanism of the chemopreventive effect of resveratrol,” Mutat Res. 2003 523-24:145-150. Dulloo AG, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M, Chantre P, Vandermander J. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr. 1999 Dec;70(6):1040-5. Emelyanov A, Fedoseev G, Krasnoschekova O, Abulimity A, Trendeleva T, Barnes PJ. “Treatment of asthma with lipid extract of New Zealand green-lipped mussel: a random- ized clinical trial,” Eur Respir J. 2002 20:596-600. Feskanich D, Singh V, Willett WC, Colditz GA. “Vitamin A intake and hip fractures among postmenopausal women,” JAMA. 2002 Jan 2;287(1):47-54. Flynn A. The role of dietary calcium in bone health. Proc Nutr Soc. 2003 Nov;62(4):851-8. Garriguet D. Bone health: osteoporosis, calcium and vitamin D. Health Rep. 2011 Sep;22(3):7-14.

Go EK, Jung KJ, Kim JM, Lim H, Lim HK, Yu Bp, Chung HY. Betiane modulates age-related NF-kappaB by thiol-enhancing action. Biol Pharm Bull. 2007 Dec;30(12):2244-9. Gusman J, Malonne H, Atassi G. “A reappraisal of the potential chemopreventive and chemotherapeutic properties of resveratrol,” Carcinogenesis. 2001 22:1111-1117. Harvey JA, Zobitz MM, Pak CY. Dose dependency of calcium absorption: a comparison of calcium carbonate and calcium citrate. J Bone Miner Res. 1988 Jun;3(3):253-8. Heaney RP, Dowell MS, Barger-Lux MJ. Absorption of calcium as the carbonate and citrate salts, with some observations on method. Osteoporos Int. 1999;9(1):19-23. Jerosch J. Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acids. Int J Rheumatol.2011;2011: 969012. Epub 2011 Aug 2. Kalpakeioglu, B. The Role of Melatonin in Rheumatic Disease. Infect Disord Drug Targets 2009 Aug 9 (4453-6). Kidd PM. “Bioavailability and activity of phytosome complexes from botanical polyphe- nols: the silymarin, curcumin, green tea, and grape seed extracts,” Altern Med Rev. 2009 Sep;14(3):226-46. Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine. 2003 Jan;10(1):3-7. Koschmieder S, D’Alo F, Radomska H, Schoneich C, Chang JS, Konopleva M, Kobayahi S, Levantini E, Suh N, Di Ruscio A, Voso MT, Watt JC, Santhanam R, Sargin B, Kantarjian H, Andreeff M, Sport MB, Perrotti D, Berdel WE, Muller-Tidow C, Serve H, and Tenen DG. “CDDO induces granulocytic differentiation of myeloid leukemic blasts through trans- lational up-regulation of p42 CCAAT enhancer-binding protein alpha,” Blood. 2007 Nov 15;110(10):3695-3705. Kundu JK, Shin YK, Kim SH, Surh YJ. “Resveratrol inhibits phorbol ester-induced expres- sion of COX-2 and activation of NF-kB in mouse skin by blocking IkB kinase activity,” Carcinogenesis. 2006 27:1465-1474. Kundu JK, Shin YK, Surh YJ. “Resveratrol modulates phorbol ester-induced pro-inflamma- tory signal trascutio pathways in mouse skin in vivo: NF-kB and AP-1 as prime targets,” Biochem Pharmacol. 2006 72:1506-1515. Lee YR, Lee JH, Noh EM, Kim EK, Song MY, Jung WS, Park SJ, Kim JS, Park JW, Kwon KB, Park BH. Guggulsterone blocks IL-1beta-mediated inflammatory responses by suppressing NF-kappaB activation in fibroblast-like synoviocytes. Life Sci. 2008 Jun 6;82(23-24):1203-9. Li H, Ruan XZ, Powis SH, Fernando R, Mon WY, Wheeler DC, Moorhead JF, Varghese Z. “EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: Evidence for a PPAR- -dependent mechanism,” Kidney International 2005 67,867-874. Li K, Kaaks R, Linseisen J, Rohrmann S. Associations of dietary calcium intake and calcium supplementation with myocardial infarction and stroke risk and overall cardiovascular mortality in the Heidelberg cohort of the European

Prospective Investigation into Cancer and Nutrition study (EPIC-Heidelberg). Heart. 2012 Jun;98(12):920-5. doi: 10.1136/heartjnl-2011-301345. Lv N. Guggulsterone a plant sterol, inhibits NFKB activation and protects pancreatic beta cells from cytokine toxicity. Mol Cell Endocrinol. 2008 July 16:289(1-2):49-59. Ma J, Johns RA, Stafford RS. Americans are not meeting current calcium recommendations. Am J Clin Nutr. 2007 May;85(5):1361-6. Majumdar AP, Banerjee S, Nautiyal J, Patel BB, Patel V, Du J, Yu Y, Elliott AA, Levi E, Sarkar FH. Curcumin synergizes with resveratrol to inhibit colon cancer. Nutr Cancer. 2009;61(4):544-53. Manna SK, Mukhopadhyay A, Aggarwal BB. “Resveratrol suppresses TNF-induced activa- tion of nuclear transcription factors NF-kB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation,” J Immunol 2000, 164:6509-6519. Massaro M, Habib A, Lubrano L, Del Turco S, Lazzerini G, Bourcier T, Weksler BB, De Caterina R. “The omega-3 fatty acid docosahexaenoate attenuates endothelial cyclooxy- genase-2 induction through both NADP(H) oxidase and PKC_ inhibition,” PNAS. 2006 July. McAnn SM, Mastronardi C, de Laurentiis A., Rettori V.”The Nitric Oxide Theory of Aging Revisited,” Ann NY Acad Sci. 2005 Dec;1057:64-84. Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bernis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29;450(7170):712-6. Muraki S, Yamamoto S, Ishibashi H, Oka H, Yoshimura N, Kawaguchi H, Nakamura K. Diet and lifestyle associated with increased bone mineral density: cross-sectional study of Japanese elderly women at an osteoporosis outpatient clinic. J Orthop Sci. 2007 Jul;12(4):317-20. Nagakura T, Matsuda S, Shichijyo K, Sugimoto H, Hata K. “Dietary supplementation with fish oil rich in omega-3 polyunsaturated fatty acids in children with bronchial asthma,” Eur Respir J. 2000 16:861-865. Nagao T, Hase T, Tokimitsu I. A green tea extract high in catechins reduces body fat and cardiovascular risks in humans. Obesity (Silver Spring). 2007 Jun;15(6):1473-83. Nam NH. “Naturally occurring NF-kappaB inhibitors,” Mini Rev Med Chem. 2006 6:945-951. Bibliography 321 322 Bibliography Novak TE, Babcock TA, Jho DH, Helton WS, Espat NJ. “NF-kappaB inhibition by omega -3 fatty acids modulates LPS-stimulated macrophage TNF-alpha transcription,” Am J Physiol Lung Cell Mol Physiol. 2003 Jan;284(1):L84-9. Ober C, Sinatra ST, Zucker M. Earthing: The Most Important Health Discovery Ever? Basic Health, 2010.

Perricone N. The Wrinkle Cure. Rodale Reach, 2000. Perricone N. The Perricone Prescription. Harper Collins, 2002. Perricone N. The Perricone Promise. Warner Books, 2004. Perricone N. Forever Young. Atria, 2010. Poliquin S, Joseph L, Gray-Donald K. Calcium and vitamin D intakes in an adult Canadian population. Can J Diet Pract Res. 2009 Spring;70(1):21-7. Rasheed Z, Anbazhagan AN, Akhtar N, Ramamurthy S, Voss FR, Haqqi TM. Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-alpha and matrix metalloproteinase-13 in human chondrocytes. Arthritis Res Ther. 2009 11(3):R71. Ridker PM, Cook NR, Lee IM, Gordon D, Gaziano JM, Manson JE, Hennekens CH, Buring JE. “A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women,” N Engl J Med. 2005 Mar 31;352(13):1293-304. Epub 2005 Mar 7. Rodríguez-Rodríguez E, Navia Lombán B, López-Sobaler AM, Ortega Anta RM; Review and future perspectives on recommended calcium intake. Nutr Hosp. 2010 May-Jun;25(3):366-74. Sawitzke AD, Shi H, Finco MF, Dunlop DD, Harris CL, Singer NG, Bradley JD, Silver D, Jackson CG, Lane NE, Oddis CV, Wolfe F, Lisse J, Furst DE, Bingham CO, Reda DJ, Moskowitz RW, Williams HJ, Clegg DO. Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT. Ann Rheum Dis. 2010 Aug;69(8):1459-64. doi: 10.1136/ard.2009.120469. Epub 2010 Jun 4. Shakibaei M, Csaki C, Nebrich S, Mobasheri A. “Resveratrol suppresses interleukin-18-in- duced inflammatory signaling and apoptosis in human articular chondrocytes: potential for use as a novel nutraceutical for the treatment of osteoarthritis,” Biochem Pharmacol 2008, 76:1426-1439. Shakibaei M, John T, Schulze-Tanzil G, Lehmann I, Mobasheri A. “Suppression of NF-kB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-o in human articular chondrocytes: implications for the treatment of osteoarthritis,” Biochem Pharmacol. 2007 73:1434-1445. Shakibaei M, Schulze-Tanzil G, John T, Mobasheri A. “Curcumin protects human chon- drocytes from IL-1p-induced inhibition of collagen type II and p1-integrin expression and activation of caspase-3:an immunomorphological study,” Ann Anat 2005, 187:487-497. Shishodia S, Aggarwal BB. Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apototic gene products, and enhances apoptosis. J Biol Chem. 2004 Nov 5;279(45):47148-58. Shulze-Tanzil G, Mobasheri A, Sendzik J, John T, Shakibaei M. “Effects of curcumin (diferu- loylmethane) on nuclear factor kB signaling in interleukin -1B-stimulated chondrocytes,” Ann NY Acad Sci. 2004 103):578-586. Sinatra, S. The Sinatra Solution: Metabolic Cardiology. Basic Health, 2005, 2008. Sikora E, Bielak-Zmijewska A, Mosieniak G, Piwocka K. “The promise of slow down ageing

may come from curcumin,” Curr Pharm Des. 2010;16(7):884-92. Sing S, Aggarwal BB. “Activation of transcription factor NF-kB is suppressed by curcumin (diferuloylmethane) [corrected],” J Biol Chem. 1995 270:24995-25000. Sterk V, B”chele B, Simmet T. Effect of food intake on the bioavailability of boswellic acids from a herbal preparation in healthy volunteers. Planta Med. 2004 Dec;70(12):1155-60. Tripathi YB, Malhotra OP, Tripathi SN. Thyroid Stimulating Action of Z-Guggulsterone Obtained from Commiphora mukul. Planta Med. 1984 Feb;50(1):78-80. Vangsness CT Jr, Spiker W, Erickson J. A review of evidence-based medicine for glucosamine and chondroitin sulfate use in knee osteoarthritis. Arthroscopy. 2009 Jan;25(1):86-94. Wang XD. “Review: absorption and metabolism of beta-carotene,” J Am Coll Nutr August 1994 vol. 13 no. 4 314-325. Welden SM, Mullen AC, Loscher CE, Hurley LA, Roche HM. “Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid,” J Nutr Biochem. 2007 apr;18(4):250-8. Yang JY, Della-Fera MA, Rayalam S, Ambati S, Hartzell DL, Park HJ, Baile CA. Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin. Life Sci. 2008 May 7;82(19-20):1032-9. Yates A, Norwig J, Maroon J, Bost J, Bradley JP, Duca M, Wecht D, Grove R, Iso A, Cobb I, Ross N, Borden M. “Evaluation of Lipid Profiles and the Use of Omega-3 Essential Fatty Acid in Professional Football Players,” Sports Health: A Multidisciplinary Approach 2009 Jan 1;(1):21-30 Yuan H, Ji WS, Wu KX, Jiao JX, Sun LH, Feng YT. Anti-inflammatory effect of Diammonium Glycyrrhizinate in a rate model of ulcerative colitis. World J Gastroenterol. 2006 July 28;12(28):4578-81. ASTAXANTHIN Lee SJ, Bai SK, Lee SK, Namkoong S, Na HG, Ha KS, Han JA, Yim SV, Chang K, Kwon YG, Lee SK, Skim YM. “Astaxanthin exhibits nitric oxide production and inflammatory gene expression by suppressing I9kappa)B kinase-dependent NF-kappaB activation,” Mol Cells. 2003 Aug 31;16(1):97-105. BETAINE Go EK, Jung KJ, Kim JM, Lim H, Lim HK, Yu Bp, Chung HY. “Betiane modulates age-related NF-kappaB by thiol-enhancing action,” Biol Pharm Bull. 2007 Dec;30(12):2244-9. BOSWELLIA Basch E, Boon H. Davies-Heerema T, Foppo I, Hashmi S, Hasskarl J, Sollars D, Ulbricht C. “Boswellia: an evidence based systematic review by the Natural Standard Research Collaboration,” J Herb Pharmacother. 2004 4(3):63-83.

Chopra A, Lavin P, Patwardhan B, Chitre D. “A 32-week randomized, Placebo-Controlled Clinical Evaluation of Ra-11, an Ayurvedic Drug, on Osteoarthritis of the Knees,” J Clin Rheumatol. 2004 Oct;10(5):236-245. Fan AY, Lao L, Zhang RX, Zhou AN, Wang LB, Moudgil KD, Lee DY, Ma ZZ, Zhang WY, Berhman BM. Effects of an acetone extract of Boswellia carteri Birdw. Burseraceae) gum resin on adjuvant-induced arthritis in lewis rats,” J Ethnopharmacol. 2005 Oct 3;101(1-3):104-9. Jing Y. “Boswellic acid acetate induces differentiation and apoptosis in leukemia cell lines,” Leuk Res. 1999 Jan 23(1):43-50. Kimmatkar N, Thawani V, Hingorani L, Khiyani R. “Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial,” Phytomedicine. 2003 Jan;10(1):3-7. Liu JJ, Duan RD. “LY294002 enhances boswellic acid-induced apoptosis in colon cancer cells,” Anticancer Res. 2009 aug;29(8):2987-91. Moussaieff A, Shohami E, Kashman Y, Fride E, Schmitz ML, Renner F, Fiebich BL, Munoz E, Ben-Neriah Y, Mechoulam R. “Incensole Acetate, a Novel anti-inflammatory com- pound isolated rom Boswellia Resin, Inhibits nuclear factor (NF)-kappa B activation,” Mol Pharmacol. 2007 Sep 26. Pang X, Zhang YZ, Sung B, Qu W, Lian X, Aggarwal BB, Liu M. “Acetyl-11-keto-beta- boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated antiogenesis,” Cancer Res. 2009 Jul 15;69(14):5893-900. Roy S, Khanna S, Krishnaraju AV, Subbaraju GV, Yasmin T, Bagchi D, Sen CK. “Regulation of vascular responses to inflammation: inducible matrix metalloproteinase-3 expression Bibliography 323 324 Bibliography in human microvascular endothelial cells is sensitive to antiinflammatory Boswellia,” Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):653-60. Siemoneit U, Hofmann B, Kather N, Lamkemeyer T, Madlung J, Franke L, Schneider G, Jauch J, Poeckel D, Werz O. “Identification and functional analysis of cyclooxygenase-1 as a molecular target of boswellic acids,” Biochem Pharmacol. 2008 Jan 15;75(2):503-13. Epub 2007 Sep 14. Sterk V, B”chele B, Simmet T. “Effect of food intake on the bioavailability of boswellic acids from a herbal preparation in healthy volunteers.,” Planta Med. 2004 Dec;70(12):1155-60. Tripathi YB. “BHUx:a patented polyherbal formulation to prevent hyperlipidemia and atherosclerosis,” Recent Pat Inflamm Allergy Drug Discov. 2009 3(1):49-57. CALCIUM Bailey RL, Dodd KW, Goldman JA, Gahche JJ, Dwyer JT, Moshfegh AJ, Sempos CT, Picciano MF. “Estimation of total usual calcium and vitamin D intakes in the United States,” J Nutr. 2010 Apr;140(4):817-22. Epub 2010 Feb 24. Borer KT. “Physical activity in the prevention and amelioration of osteoporosis in women : interaction of mechanical, hormonal and dietary factors,” Sports Med. 2005;35(9):779-830.

Cao JJ, Nielsen FH. “Acid diet (high-meat protein) effects on calcium metabolism and bone health,” Curr Opin Clin Nutr Metab Care. 2010 Nov;13(6):698-702. Cashman KD. “Diet, nutrition, and bone health,” J Nutr. 2007 Nov;137(11 Suppl):2507S-2512S. Flynn A. “The role of dietary calcium in bone health,” Proc Nutr Soc. 2003 Nov;62(4):851-8. Francis RM. “What do we currently know about nutrition and bone health in relation to United Kingdom public health policy with particular reference to calcium and vitamin D?” Br J Nutr. 2008 Jan;99(1):155-9. Epub 2007 Jul 19. Garriguet D. “Bone health: osteoporosis, calcium and vitamin D,” Health Rep. 2011 Sep;22(3):7-14. Harvey JA, Zobitz MM, Pak CY. “Dose dependency of calcium absorption: a comparison of calcium carbonate and calcium citrate,” J Bone Miner Res. 1988 Jun;3(3):253-8. Heaney RP, Dowell MS, Barger-Lux MJ. “Absorption of calcium as the carbonate and citrate salts, with some observations on method,” Osteoporos Int. 1999;9(1):19-23. Ilich JZ, Kerstetter JE. “Nutrition in bone health revisited: a story beyond calcium,” J Am Coll Nutr. 2000 Nov-Dec;19(6):715-37. Lips P, Bouillon R, van Schoor NM, Vanderschueren D, Verschueren S, Kuchuk N, Milisen K, Boonen S. “Reducing fracture risk with calcium and vitamin D,” Clin Endocrinol (Oxf). 2010 Sep;73(3):277-85. Ma J, Johns RA, Stafford RS. “Americans are not meeting current calcium recommenda- tions,” Am J Clin Nutr. 2007 May;85(5):1361-6. NIH Office of Dietary Supplements http://ods.od.nih.gov/factsheets/ Calcium-HealthProfessional/#h2 Poliquin S, Joseph L, Gray-Donald K. “Calcium and vitamin D intakes in an adult Canadian population,” Can J Diet Pract Res. 2009 Spring;70(1):21-7. Rodríguez-Rodríguez E, Navia Lombán B, López-Sobaler AM, Ortega Anta RM; “Review and future perspectives on recommended calcium intake,” Nutr Hosp. 2010 May-Jun;25(3):366-74. Shahar DR, Schwarzfuchs D, Fraser D, Vardi H, Thiery J, Fiedler GM, Blüher M, Stumvoll M, Stampfer MJ, Shai I; “Dairy calcium intake, serum vitamin D, and successful weight loss,” Am J Clin Nutr. 2010 Nov;92(5):1017-22. Epub 2010 Sep 1. Tucker KL. “Osteoporosis prevention and nutrition,” Curr Osteoporos Rep. 2009 Dec;7(4):111-7. Zemel MB, Thompson W, Milstead A, Morris K, Campbell P. “Calcium and dairy accel- eration of weight and fat loss during energy restriction in obese adults,” Obes Res. 2004 Apr;12(4):582-90. CITRUS PECTIN Chen CH, Sheu MT, Chen TF, Wang YC, Hou WC, Liu DZ, Chung TC, Liang YC. “Suppression of endotoxin-induced proinflammatory responses by citrus pectin through blocking LPS signaling pathways,” Biochem Pharmacol. 2006 Oct 16;72(8):1001-9. COCOA

Hooper L, Kroon PA, Rimm EB, Cohn JS, Harvey I, Le Cornu KA, Ryder JJ, Hall WL, Cassidy A. “Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of random- ized controlled trials,” Am J Clin Nutr. 2008 Jul;88(1):38-50. Lee KS, “Cocoa polyphenols inhibit phorbol ester induced superoxidation formation in cultured HL-60 cell and expression of cyclooxygenase-2 and activation of NFKB and MAPKs in mouse skin in vivo,” J Nutr 2006 May;136(5):1150-5. Rimbach G, Melchin M, Moehring J, Wagner AE. “Polyphenols from cocoa and vascular health-a critical review,” Int J Mol Sci. 2009 Nov 20;10(10):4290-309. CURCUMIN Aggarwal BB, Harikumar KB. “Potential therapeutic effects of curcumin, the anti-inflamma- tory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune, and neoplastic diseases,” Int J Biochem Cell Biol. 2009 Jan;41(1):40-59. Aggarwal S, Ichikawa H, Takada Y, Sandur SK, Shishodia S, Aggarwal BB. “Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt acti- vation,” Mol Pharmacol. 2006 69:195-206. Aggarwal BB, Kumar A, Bharti AC. “Anticancer potential of curcumin: preclinical and clinical studies,” Anticancer Res. 2003 Jan-Feb;23(1A):363-98. Bibliography 325 326 Bibliography Bar-Sela G, Epelbaum R, Schaffer M. “Curcumin as an Anti-Cancer Agent: Review of the Gap between Basic and Clinical Applications,” Curr Med Chem. 2009 Nov 24. Charti AC, Donato N, Singh S, Aggarwal BB. “Curcumin (diferuloylmethane) down-reg- ulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis,” Blood. 2003 Feb 1;101(3):1053-62. Chainani-Wu N. “Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa),” J Altern Complement Med. 2003 9:161-168. Cheng AL, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, Ko JY, Lin JT, Lin BR, Ming-Shiang W, Yu HS, Jee SH, Chen GS, Chen TM, Chen CA, Lai MK, Pu YS, Pan MH, Wang YJ, Tsai CC, Hsieh CY. “Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions,” Anticancer Res 2001. 21:2895-2900. Csaki, C, Mobasheri A, Shakibaei M. “Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of Il-1B-induced NF-kB- mediated inflammation and apoptosis,” Arthritis Res & Therapy. 2009 11:R165. Gonzales AM, Orlando RA. “Curcumin and resveratrol inhibit nuclear factor-kappaB- mediated cytokine expression in adipocytes,” Nut & Metab. 2008 5:17. Hanai H, Sugimoto K. “Curcumin has bright prospects for the treatment of inflammatory bowel disease,” Curr Pharm Des. 2009 15(18):2087-94. Henrotin Y, Clutterbuck AL, Allaway D, Lodwig EM, Harris P, Mathy-Hartert M, Shakibaei M, Mobasheri A. “Biological actions of curcumin on articular chondrocytes,” Osteoarthritis Cartilage. 2010 Feb;18(2):141-9.

Hsu CH, Cheng AL. “Clinical studies with curcumin,” Adv Exp Med Biol. 2007 595:471-480. Jurenka JS. “Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research,” Altern Med Rev. 2009 Jun;14(2):141-53. Kasinski AL, Du Y, Thomas SL, Zhao J, Sun SY, Khuri FR, Wang CY, Shoji M, Sun A, Snyder JP, Liotta D, Fu H. “Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin,” Mol Pharmacol. 2008 Sep;74(3):654-61. Liacini A, Sylvester J, Li WQ, Zafarullah M. “Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondro- cytes,” Matrix Biol. 2002 Apr;21(3):251-62. Pae HO, Jeong SO, Kim HS, Kim SH, Song YS, Kim SK, Chai KY, Chung HT. “Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-kappaB activation in RAW264.7 macrophages activated with LPS,” Mol Nutr Food Res. 2008 Sep;52(9):1082-91. Saha A, Kuzuhara T, Echigo N, Suganuma M, Fujiki H. “New role of (-)-Epicatechin in enhancing the induction of growth inhibition and apoptosis in human lung cancer cells by curcumin,” Cancer Prev Res (Phila Pa). 2010 July 6. Shakibaei M, John T, Schulze-Tanzil G, Lehmann I, Mobasheri A. “Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis,” Biochem Pharmacol. 2007 May 1;73(9):1434-45. Shakibai M, Schulze-Tanzil G, John T, Mobasheri A. “Curcumin protects human chon- drocytes from IL-11beta-induced inhibition of collagen type II and beta1-integrin expres- sion and activation of caspase-3:an immunomorphological study,” Ann Anat. 2005 Nov;187(5-6):487-97. Sharma RA, Steward WP, Gescher AJ. “Pharmacokinetics and pharmacodynamics of curcumin,” Adv Exp Med Biol. 2007 595:453-470. Shishodia S, Sethi G, Aggarwal BB. “Curcumin: getting back to the roots,” Ann NY Acad Sci. 2005 Nov;1056:206-17. Sikora E, Scapagnini G, Barbagallo M. “Curcumin, inflammation, ageing and age-related diseases,” Immun Ageing. 2010 Jan 17;7(1):1. Singh S, Aggarwal BB. “Activation of transcription factor NF-kappa B is suppressed by cur- cumin (diferuloylmethane) [corrected],” J Biol Chem. 1995 Oct 20;270(42):24995-5000. Singh S, Khar A. “Biological effects of curcumin and its role in cancer chemoprevention and therapy,” Anticancer Agents Med Chem. 2006 6:259-270. Weber WM, Hunsaker LA, Roybal CN, Bobrovnikova-Marjon EV, Abcouwer SF, Royer RE, Deck LM, Jagt DL Vander. “Activation of NFkappaB is inhibited by curcumin and related enones,” Bioorg Med Chem 2006 14:2450-2461. GARLIC

Aviello G, Abenavoli L, Borrelli F, Capasso R, Izzo AA, Lembo F, Romano B, Capasso F. “Garlic: empiricism or science?” Nat Prod Commun. 2009 Dec;4(12):1785-96. Borrelli F, Capasso R, Izzo AA. “Garlic (Allium sativum L.): adverse effects and drug inter- actions in humans,” Mol Nutr Food Res. 2007 Nov;51(11):1386-97. Brace LD. “Cardiovascular benefits of garlic (Allium sativum L),” J Cardiovasc Nurs. 2002 Jul;16(4):33-49. Hasan N, Siddiqui MU, Toossi Z, Khan S, Iqbal J, Islam N. “Allicin-induced suppression of Mycobacterium tuberculosis 85B mRNA in human monocytes,” Biochem Biophys Res Commun. 2007 Apr 6;355(2):471-6. Rai SK, Sharma M, Tiwari M. “Inhibitory effect of novel diallyldisulfide analogs on HMG- CoA reductase expression in hypercholesterolemic rats: CREB as a potential upstream target,” Life Sci. 2009 Jul 31;85(5-6):211-9. Bibliography 327 328 Bibliography GINGER Ahmed RS, Suke SG, Seth V, Chakraborti A, Tripathi AK, Banerjee BD. “Protective effects of dietary ginger (Zingiber officinales Rosc.) on lindane-induced oxidative stress in rats,” Phytother Res. 2008 Jul;22(7):902-6. Ahmed RS, Seth V, Banerjee BD. “Influence of dietary ginger (Zingiber officinales Rosc) on antioxidant defense system in rat: comparison with ascorbic acid,” Indian J Exp Biol. 2000 Jun;38(6):604-6. Aktan F, Henness S, Tran VH, Duke CC, Roufogalis BD, Ammit AJ. “Gingerol metabolite and a synthetic analogue Capsarol inhibit macrophage NF-kappaB-mediated iNOS gene expression and enzyme activity,” Planta Med. 2006 Jun;72(8):727-34. Epub 2006 May 29. Altman RD, Marcussen KC. “Effects of a ginger extract on knee pain in patients with osteoarthritis,” Arthritis Rheum. 2001 Nov;44(11):2531-8. Bode, Ann. “Dietary Ginger may work against cancer growth,” Science Daily. 2003 Oct 29. Chen ZY, Peng C, Jiao R, Wong YM, Yang N, Huang Y. “Anti-hypertensive nutraceuticals and functional foods,” J Agric Food Chem. 2009 Jun 10;57(11):4485-99. Ishiguro K, Ando T, Maeda O, Ohmiya N, Niwa Y, Kadomatsu K, Goto H. “Ginger ingre- dients reduce viability of gastric cancer cells via distinct mechanisms,” Biochem Biophys Res Commun. 2007 Oct 12;362(1):218-23. Epub 2007 Aug 10. GLUCOSAMINE/CHONDROITIN Bruyere O, Reginster JY. “Glucosamine and chondroitin sulfate as the therapeutic agents for knee and hip osteoarthritis,” Drugs Aging. 2007 24(7):573-80. Clegg DO, Reda DJ, Harris CL, Klein MA, O’Dell JR, Hooper MM, Bradley JD, Bingham CO 3rd, Weisman MH, Jackson CG, Lane NE, Cush JJ, Moreland LW, Schumacher HR Jr., Oddis CV, Wolfe F, Molitor JA, Yocum DE, Schnitzer TJ, Furst DE, Sawitzke AD, Shi H, Brandt KD, Moskowitz RW, Williams HJ. “Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis,” N Engl J Med. 2006 Feb 23;354(8):795-808. Herrero-Beaumont G, Ivorra JA, Del Carmen TM, Blanco FJ, Benito P, Martin-Mola E, Paulino J, Marenco JL, Porto A, Laffon A, Araujo D, Fugueroa M, Branco J.

“Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator,” Arthritis Rheum. 2007 Feb;56(2):555-67. Jerosch J. “Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acids,” Int J Rheumatol. 2011;2011: 969012. Epub 2011 Aug 2. Monfort J, Martel-Pelletier J, Pelletier JP. “Chondroitin sulphate for symptomatic osteoar- thritis: critical appraisal of meta-analyses,” Curr Med Res Opin. 2008 May;24(5):1303-8. Moreno-Rubio J, Herrero-Beaumont G, Tardio L, Alvarez-Soria MA, Largo R. “Nonsteroidal antiinflammatory drugs and prostaglandin E92) modulate the synthesis of osteoprotegerin and RANKL in the cartilage of patients with severe knee osteoarthritis,” Arthritis Rheum. 2010 Feb;62(2):478-88. National Center for Complimentary and Alternative Medicine. “The NIH glucosamine/ chondroitin arthritis intervention trial (GAIT),” J Pain Palliat Care Pharmacother. 2008 22(1):39-43. Pavelka, K, Gatterova J, Olejarova M, Machacek S, Giacovelli G, Rovati LC. “Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year randomized, placebo- controlled, double-blind study,” Arch Intern Med. 2002 Oct 14;162(18):2113-23. Sawitzke AD, Shi H, Finco MF, Dunlop DD, Harris CL, Singer NG, Bradley JD, Silver D, Jackson CG, Lane NE, Oddis CV, Wolfe F, Lisse J, Furst DE, Bingham CO, Reda DJ, Moskowitz RW, Williams HJ, Clegg DO. Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT. Ann Rheum Dis. 2010 Aug;69(8):1459-64. doi: 10.1136/ard.2009.120469. Epub 2010 Jun 4. Scholtissen S, Bruyere O, Neuprez A, Severens JL, Herrero-Beaumont G, Rovati L, Hiligsmann M, Reginster JY. “Glucosamine sulphate in the treatment of knee osteoarthritis: cost-effectiveness comparison with paracetamol,” Int J Clin Pract. 2010 64(6):756-762. Tat SK, Pelletier JP, Velasco CR, Padrines M, Martel-Pelletier J. “New perspective in osteo- arthritis: the OPG and RANKL system as a potential therapeutic target?” Keio J Med. 2009 Mar;58(1):29-40. Uebelhart D. “Clinical review of chondroitin sulfate in osteoarthritis,” Osteoarthritis Cartilage. 2008 16 Suppl 3:S19-21. Vangsness CT Jr, Spiker W, Erickson J. “A review of evidence-based medicine for glu- cosamine and chondroitin sulfate use in knee osteoarthritis,” Arthroscopy. 2009 Jan;25(1):86-94. GRAPE SEED Cheng M, Gao HQ, Xu L, Li BY, Zhang H, Li XH. “Cardioprotective effects of grape seed proanthocyanidins extracts in streptozocin induced diabetic rats,” J Cardiovasc Pharmacol. 2007 Nov;50(5):503-9.

Li BY, Li XL, Gao HQ, Zhang JH, Cai Q, Cheng M, Lu M. “Grape seed procyanidin B2 inhibits advanced glycation end product-induced endothelial cell apoptosis through regulating GSK3β phosphorylation,” Cell Biol Int. 2011 Jul;35(7):663-9. Li X, Xu L, Gao H, Li B, Cheng M. “Effects of grape seed proanthocyanidins extracts on AGEs and expression of bone morphogenetic protein-7 in diabetic rats,” J Nephrol. 2008 Sep-Oct;21(5):722-33. Renaud S, de Lorgeril M. “Wine, alcohol, platelets, and the French paradox for coronary heart disease,” Lancet. 1992 Jun 20;339(8808):1523-6. Sun C, McIntyre K, Saleem A, Haddad PS, Arnason JT. “The relationship between antigly- cation activity and procyanidin and phenolic content in commercial grape seed products,” Can J Physiol Pharmacol. 2012 Feb;90(2):167-74. Epub 2012 Feb 9. Xu L, Li B, Cheng M, Zhang W, Pan J, Zhang C, Gao H. “Oral administration of grape seed proanthocyanidin extracts downregulate RAGE dependant nuclear factor-kappa BP65 expression in the hippocampus of streptozotocin induced diabetic rats,” Exp Clin Endocrinol Diabetes. 2008 Apr;116(4):215-24. Bibliography 329 330 Bibliography GREEN TEA Adcocks C, Collin P, Buttle DJ. “Catechins from green tea (Camellia sinensis) inhibit bovine and human cartilage proteoglycan and type II collagen degradation in vitro,” J Nutr. 2002 Mar;132(3):341-6. Akhtar, N. “Epigallocaatechin-3-gallate supresses the global interleukin-1-beta-induced inflammatory response in human chondrocytes.” Arthritis Res Ter. 13.3 (2011): R93. Auvichayapat P, Prapochanung M, Tunkamnerdthai O, Sripanidkulchai BO, Auvichayapat N, Thinkhamrop B, Kunhasura S, Wongpratoom S, Sinawat S. Hongprapas P. “Effectiveness of green tea on weight reduction in obese Thais: A randomized, controlled trial,” Physiol Behav. 2008 Feb 27;93(3):486-91. Devine A, Hodgson JM, Dick IM, Prince RL. “Tea drinking is associated with benefits on bone density in older women,” Am J Clin Nutr. 2007 Oct;86(4):1243-7. Dulloo AG, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M, Chantre P, Vandermander J. “Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans,” Am J Clin Nutr. 1999 Dec;70(6):1040-5. Guiterrez-Orozco F, Stephens BR, Neilson AP, Green R, Ferruzzi MG, Bomser JA. “Green and Black tea inhibit cytokine-induced Il-8 production and secretion in AGS gastric cancer cells via inhibition of NFkappaB activity,” Planta Med. 2010 May 26. Hou DX, Luo D, Tanigawa S, Hashimoto F, Uto T, Masuzaki S, Fujii M, Sakata Y. “Prodelphinidin B-r3’-O-gallate, a teal polyphenol, is involved in the inhibition of COX-2 and iNOS via the downregulation of TAK1-NF-kappaB pathway,” Biochem Pharmacol. 2007 Sep 1;74(5):745-51. Kalra N, Seth K, Prasad S, Singh M, Pant AB, Shukia Y. “Theaflavins induced apoptosis of NNCaP cells is mediated through induction of p53, down-regulation of NF-kappa B and mitogen-activated protein kinases pathways,” Life Sci. 2007 May 16;80(23):2137-46.

Katiyar, SK. “Green tea: a new option for the prevention or control of osteoarthritis.” Arthritis Res Ther. 13.4 (2011): 121. Lambert JD, Elias RJ. “The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer prevention,” Arch Biochem Biophys. 2010 June 15. Landis-Piwowar K, Chen D, Chan TH, Dou QP. “Inhibition of catechol-Omicron-meth- yltransferase activity in human breast cancer cells enhances the biological effect of the green tea polyphenol (-)-EGCG,” Oncol Rep. 2010 Aug;24(2):563-9. Link A, Balaguer F, Goel A. “Cancer chemoprevention by dietary polyphenols: promising role for epigenetics,” Biochem Pharmacol. 2010 Jun 26. Muraki S, Yamamoto S, Ishibashi H, Oka H, Yoshimura N, Kawaguchi H, Nakamura K. “Diet and lifestyle associated with increased bone mineral density: cross-sectional study of Japanese elderly women at an osteoporosis outpatient clinic,” J Orthop Sci. 2007 Jul;12(4):317-20. Nagao T, Hase T, Tokimitsu I. “A green tea extract high in catechins reduces body fat and cardiovascular risks in humans,” Obesity (Silver Spring). 2007 Jun;15(6):1473-83. Rasheed Z, Anbazhagan AN, Akhtar N, Ramamurthy S, Voss FR, Haqqi TM. “Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-alpha and matrix metalloproteinase-13 in human chondrocytes,” Arthritis Res Ther. 2009 11(3):R71. Wang P, Aronson WJ, Huang M, Zhang Y, Lee RP, Heber D, Henning SM. “Green Tea polyphenols and metabolites in Prostatectomy Tissue: implications for cancer prevention,” Cancer Prev Res (Phila Pa). 2010 Jul 13. GUGGULSTERONES Deng R. “Therapeutic effects of guggul and its constituent guggulsterone: cardiovascular benefits,” Cardiovasc Drug Rev. 2007 Winter;25(4):375-90. Ichikawa H, Aggarwal BB. “Guggulsterone inhibits osteoclastogenesis induced by recep- tor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation,” Clin Cancer Res. 2006 Jan 15;12(2):662-8. Lee YR, Lee JH, Noh EM, Kim EK, Song MY, Jung WS, Park SJ, Kim JS, Park JW, Kwon KB, Park BH. “Guggulsterone blocks IL-1beta-mediated inflammatory responses by suppressing NF-kappaB activation in fibroblast-like synoviocytes,” Life Sci. 2008 Jun 6;82(23-24):1203-9. Lv N. “Guggulsterone a plant sterol, inhibits NFKB activation and protects pancreatic beta cells from cytokine toxicity,” Mol Cell Endocrinol. 2008 July 16:289(1-2):49-59. Tripathi YB, Malhotra OP, Tripathi SN. “Thyroid Stimulating Action of Z-Guggulsterone Obtained from Commiphora mukul,” Planta Med. 1984 Feb;50(1):78-80. Shishodia S, Aggarwal BB. “Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apototic gene products, and enhances apopto- sis,” J Biol Chem. 2004 Nov 5;279(45):47148-58. Szapary PO, Wolfe ML, Bloedon LT, Cucchiara AJ, DerMarderosian AH, Cirigliano MD, Rader DJ. “Guggulipid for the treatment of hypercholesterolemia: a randomized controlled trial.,” JAMA. 2003 Aug 13;290(6):765-72.

Yu Bz, Kaimal R, Bai S, El Sayed KA, Tatulian SA, Apitz RJ, Jain MK, Deng R, Berg OG. “Effect of guggulsterone and cembranoids of Commiphora mukul on pancreatic phospholipase A(2): role in hypocholesterolemia,” J Nat Prod. 2009 Jan;72(1):24-8. KAVA Denham A, McIntyre M, Whitehouse J. “Kava--the unfolding story: report on a work-in- progress,” J Altern Complement Med. 2002 Jun;8(3):237-63. Folmer F, Blasius R, Morceau F, Tabudravu , Dicato M, Jaspars M, Diederich M. “Inhibition of TNFalpha-induced activation of nuclear factor kappaB by kava (Piper methysticum) derivatives,” Biochem Pharmacol. 2006 Apr 14;71(8):1206-18. Bibliography 331 332 Bibliography Sarris J, Kavanagh DJ, Byrne G, Bone KM, Adams J, Deed G. “The Kava Anxiety Depression Spectrum Study (KADSS): a randomized, placebo-controlled crossover trial using an aque- ous extract of Piper methysticum,” Psychopharmacology (Berl). 2009 Aug;205(3):399-407. Epub 2009 May 9. Teschke R, Genthner A, Wolff A. “Kava hepatotoxicity: comparison of aqueous, etha- nolic, acetonic kava extracts and kava-herbs mixtures,” J Ethnopharmacol. 2009 Jun 25;123(3):378-84. Epub 2009 Apr 5. Teschke R, Sarris J, Schweitzer I. “Kava hepatotoxicity in traditional and modern use: the presumed Pacific kava paradox hypothesis revisited,” Br J Clin Pharmacol. 2012 Feb;73(2):170-4. doi: 10.1111/j.1365-2125.2011.04070.x. United States Centers for Disease Control and Prevention (2002). “Hepatic Toxicity Possibly Associated with Kava-Containing Products – United States, Germany, and Switzerland, 1999 2002”. Morbidity & Mortality Weekly Report 51 (47): 1065–1067. LICORICE Hsu YL, WU LY, Hou MF, Tsai EM, Lee JN, Liang HL, Jong YJ, Hung CH, Kuo PL. “Glabridin, an isoflavan from licorice root, inhibits migration, invasion and angiogenesis of MDA-MB-231 human breast adenocarcinoma cells by inhibiting focal adhesion kinase/Rho signaling pathway,” Mol Nutr Food Res. 2010 Jul 12. Kim JK, Oh SM, Kwon HS, Oh YS, Lim SS, Shin HK. “Anti-inflammatory effect of roasted licorice extracts on lipopolysaccharide-induced inflammatory responses in murine mac- rophages,” Biochem Biophys Res Commun. 2006 Jul 7;345(3):1215-23. Kown GT, Cho HJ, Chung WY, Park KK, Moon A, Park JH. “Isoliquiritigenin inhibits migra- tion and invasion of prostate cancer cells: possible mediation by decreased JNK/AP-1 signaling,” J Nutr Biochem. 2009 Sep;20(9):663-76. Kwon HM, Choi YJ, Choi JS, Kang SW, Bae JY, Kang IJ, Jun JG, Lee SS, Lim SS, Kang YH. “Blockade of cytokine-induced endothelial cell adhesion molecule expression by licorice isoliquiritigenin through NF-kappaB signal disruption,” Exp Biol Med (Maywood). 2007 Feb;232(2):235-45. Liu X, Jing L. “Study of roasted liquorice decoction on arrhythmia,” Zhongguo Zhong Yao Za Zhi. 2007 (Dec;32(23):2471—3. Park SY, Lim SS, Kim JK, Kang IJ, Kim JS, Lee C, Kim J, Park JH. “Hexane-ethanol extract of Glycyrrhiza ralensis containing licoricidin inhibits the metastatic capacity of DU145 human prostate cancer cells,” Br J Nutr. 2010 May 21:1-11.

Stewart PM, Prescott SM. “Can licorice lick colon cancer?” J Clin Invest. 2009 Apr;119(4):760-3. Urizar NL, Liverman AB, Dodds DT, Silva FV, Ordentlich P, Yan Y, Gonzalez FJ, Heyman RA, Mangelsdorf DJ, Moore DD. “A natural product that lowers cholesterol as an antagonist ligand for FXR,” Science. 2002 May 31;296(5573):1703-6. Yuan H, Ji WS, Wu KX, Jiao JX, Sun LH, Feng YT. “Anti-inflammatory effect of Diammonium Glycyrrhizinate in a rate model of ulcerative colitis,” World J Gastroenterol. 2006 July 28;12(28):4578-81. LUTEIN Kim JH, Na HJ, Kim CK, Kim JY, Ha KS, Lee H, Chung HT, Kwon HJ, Kwon YG, Kim YM. “The non-provitamin A carotenoid, lutein, inhibits NF-kappaB-dependent gene expres- sion through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-kappaB-inducing kinase pathways: role of H(2)O(2) in NF-kappaB activation,” Free Radic Biol Med. 2008 Sep 15;45(6):885-96. MANGOSTIN Devi Sampath P, Vijayaraghavan K. “Cardioprotective effect of alpha-mangostin, a xan- thone derivative from mangosteen on tissue defense system against isoproterenol-induced myocardial infarction in rats,” J. Biochem Mol Toxicol. 2007;21(6):336-9. Hung SH, Shen KH, Wu CH, Liu CL, Shih YW. “Alpha-mangostin suppresses PC-3 human prostate carcinoma cell metastasis by inhibiting matrix metalloproteinase-2/9 and uro- kinase-plasminogen expression through the JNK signaling pathway,” J Agric Food Chem. 2009 Feb 25;54(4):1291-8. Nakatani K, Yamakuni T, Kondo N, Arakawa T, Oosawa K, Shimura S, Inoue H, Ohizumi Y. “Gamma-Mangostin inhibits inhibitor-kappaB kinase activity and decreases lipopolysac- charide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells,” Mol Pharmacol. 2004 Sep; 66(3):667-74. Nakatani K. “Inhibition of cyclooxygenase and prostaglandin E2 synthesis by gamma mangostin axthanone derivative in mangosteen, in C6 rat glioma cells,” Biochem Pharm 2002 63 73-79. MELATONIN Cardinali DP, García AP, Cano P, Esquifino AI. “Melatonin role in experimental arthritis,” Curr Drug Targets Immune Endocr Metabol Disord. 2004 Mar;4(1):1-10. Cutolo, M. “The Melatonin Cytokine Connection in Rheumatoid Arthritis,” ANN Rheum Dis 2005 August 64 (8) 1109-1111. Kalpakeioglu, B. “The Role of Melatonin in Rheumatic Disease,” Infect Disord Drug Targets 2009 Aug 9 (4453-6). Korkmaz A, Reiter RJ, Topal T, Manchester LC, Oter S, Tan DX. “Melatonin: an established antioxidant worth of use in clinical trials,” Mol Med. 2009 Jan-Feb;15(1-2):43-50. Li JH, Yu JP, Yu HG, Xu XM, Yu LL, Liu J, Luo HS. “Melatonin reduces inflammatory injury through inhibiting NF-kappaB activation in rats with colitis,” Mediators Inflamm. 2005 aug 31;2005(4):185-93. Tamura EK, Cecon E, Monteiro AW, Silva CL, Markus RP. “Melatonin inhibits LPS-induced NO production in rat endothelial cells,” J Pineal Res. 2009 Apr;46(3):268-74.

Bibliography 333 334 Bibliography NAC Bickley JF, Ciucci A, Evans P, Roberts SM, Ross N, Santoro MG. “Reactions of some cyclo- pentenones with selected cysteine derivatives and biological activities of the product thioethers,” Bioorg. Med Chem. 2004 Jun 15;12(12):3221-7. Jimenez-Lopez JM, Wu D, Cederbaum AI. “Synergistic toxicity induced by prolonged glutathione depletion and inhibition of nuclear factor-kappaB signaling in liver cells,” Toxicol In Vitro. 2008 Feb;22(1):106-15. Oka S, Kamata H, Kamata K, Yagisawa H, Hirata H. “N-acetylcysteine suppresses TNF- induced NF-kappaB activation through inhibition of IkappaB kinases,” FEBS Lett. 2000 Apr 28;472(2-3):196-202. Schreck R, Rieber P, Baeuerle PA. “Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappaB transcription factor and HIV-1,” EMBO J. 1991 Aug;10(8):2247-58. Wang YT, Wang J, Zhao M, DI HJ. “Inhibitory effects of reduced glutathione sodium on renal nuclear factor-kappaB expression in rats with diabetes of different stages,” Nan Fang Yi Ke Da Xue Xue Bao. 2007 Mar;27(3):332-5. Zahid M, Saeed M, Ali MF, Rogan EG, Cavalieri EL. “N-acetylcysteine blocks forma- tion of cancer-initiating estrogen-DNA adducts in cells,” Free Radic Biol Med. 2010 Aug 1;49(3):392-400. OMEGAS Arterburn LM, Hall EB, Oken H. Distribution, interconversion, and dose response of n-3 fatty acids in humans. Am J Clin Nutr. 2006 Jun;83(6 Suppl):1467S-1476S. Bagga D, Wang L, Farias-Eisner R, Glaspy JA, and Reddy ST. “Differential effects of pros- taglandin derived from Omega 6 and Omega 3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion,” PNAS Feb 18, 2003 100(4) 1751-56. Bourre JM. “Dietary omega 3 fatty acids for women,” Biomed Pharmacother. 2007 Feb-Apr;61(2):105-12. Brenna JT, Salem N Jr, Sinclair AJ, Cunnane SC. “Alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans,” Prostaglandins Leukot Essent Fatty Acids. 2009 Feb-Mar;80(2-3):85-91. Cao J, Schwichtenberg KA, Hanson NQ, Tsai MY. Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids. Clin Chem. 2006 Dec;52(12):2265-72. Epub 2006 Oct 19. Denkins J. “Role of Omega-3 PUF on COX-2 metabolism in brain metastatic melanoma,” J. Lipid Res. 2005 Jun v46.no6;1278-84. Emelyanov A, Fedoseev G, Krasnoschekova O, Abulimity A, Trendeleva T, Barnes PJ. “Treatment of asthma with lipid extract of New Zealand green-lipped mussel: a random- ized clinical trial,” Eur Respir J. 2002 20:596-600. Fite A, Goua M. “Regulation of adhesion molecule expression in human endothelial and smooth muscle cells by omega-3 fatty acids and conjugated linoleic acids:

involvement of the transcription factor NFKB?” Prostaglandins, Leukotrienes and Essential Fatty Acids. 2008 Jan;78(1):33-43. Fradet V. “Dietary Omega-3 fatty acids COX-2 genetic variation and aggressive prostate cancer risk,” Clin Can Res. March 2009. Gebauer SK, Psota TL, Harris WS, Kris-Etherton PM. “N-3 fatty acid dietary recommen- dations and food sources to achieve essentiality and cardiovascular benefits,” Am J Clin Nutr. 2006 Jun;83(6 Suppl):1526S-1535S. Kris-Etherton PM, Grieger JA, Etherton TD. “Dietary reference intakes for DHA and EPA,” Prostaglandins Leukot Essent Fatty Acids. 2009 Aug-Sep;81(2-3):99-104. Lee CH, Lum JHK, Ng CKC, McKay J, Butt YKC,Wong MS and Lo SCL. “Pain Controlling and Cytokine-regulating Effects of Lyprinol, a Lipid Extract of Perna Canaliculus, in a Rat Adjuvant-induced Arthritis Model,” eCAM 2009 6(2):239-245. Lee, JH, O’Keefe JH, Lavie CJ, Harris WS. “Omega-3 fatty acids: cardiovascular benefits, sources and sustainability,” Nat Rev Cardiol. 2009 Dec;6(12):753-8. Nagakura T, Matsuda S, Shichijyo K, Sugimoto H, Hata K. “Dietary supplementation with fish oil rich in omega-3 polyunsaturated fatty acids in children with bronchial asthma,” Eur Respir J. 2000 16:861-865. Ottestad I, Hassani S, Borge GI, Kohler A, Vogt G, Hyötyläinen T, Orešič M, Brønner KW, Holven KB, Ulven SM, Myhrstad MC. Fish oil supplementation alters the plasma lipidomic profile and increases long-chain PUFAs of phospholipids and triglycerides in healthy subjects. PLoS One. 2012;7(8):e42550. Sukumaran S, Pittman KB, Patterson WK, Dickson J, Yeend S, Townsend A, Broadbridge V, Price TJ. “A phase I study to determine the safety, tolerability and maximum tolerated dose of green-lipped mussel (Perna canaliculus) lipid extract, in patients with advanced prostate and breast cancer,” Annals of Oncology. Doi:10.1093. Vidgren HM, Agren JJ, Schwab U, Rissanen T, Hänninen O, Uusitupa MI. Incorporation of n-3 fatty acids into plasma lipid fractions, and erythrocyte membranes and platelets during dietary supplementation with fish, fish oil, and docosahexaenoic acid-rich oil among healthy young men. Lipids. 1997 Jul;32(7):697-705. Wang S, Wu D, Matthan NR, Lmon-Fava S, Lecker JL, Lichtenstein AH. “Reduction in dietary omega-6 polyunsaturated fatty acids: eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouse,” Atherosclerosis. 2009 May;204(1):147-55. Wann AK, Mistry J, Blain EJ, Michael-Titus AT, Knight MM. “Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation,” Arthritis Res Ther. 2010;12(6):R207. Epub 2010 Nov 8. POMEGRANATE Ahmed S, Wang N, Hafeez BB, Cheruvu VK, Haqqi TM. “Punica granatum L. extract inhibits IL-1beta-induced expression of matrix metalloproteinases by inhibiting the acti- vation of MAP kinases and NF-kappaB in human chondrocytes in vitro,” J Nutr. 2005 Sep;135(9):2096-102.

Basu A, Penugonda K. “Pomegranate juice: a heart-healthy fruit juice,” Nutr Rev. 2009 Jan;67(1):49-56. Khan N, Hadi N, Afaq F, Syed DN, Kweon MH, Mukhtar H. “Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice,” Carcinogenesis. 2007 Jan;28(1):163-73. QUERCETIN Kim BH, Lee IJ, Lee HY, Han SB, Hong JT, Ahn B, Lee CK, Kim Y. “Quercetin 3-O-beta-(2”- galloy1)-glucopyranoside inhibits endotoxin LPS-induced IL-6 expression and NF-kappa B activation in macrophages,” Cytokine. 2007 Sep;39(3):207-15. Bibliography 335 336 Bibliography Min YD, CHoi CH, Bark H, Son HY, Park HH, Lee S, Park JW, Park EK, Shin HI, Kim SH. “Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-kappaB and p38 MAPK in HMC-1 human mast cell line,” Inflamm Res. 2007 May;56(5):210-5. Yang JY, Della-Fera MA, Rayalam S, Ambati S, Hartzell DL, Park HJ, Baile CA. “Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combina- tions of resveratrol and quercetin,” Life Sci. 2008 May 7;82(19-20):1032-9. Epub 2008 Mar 21. RESVERATROL Armour SM, Baur JA, Hsieh SN, Land-Bracha A, Thomas Sm, Sinclair DA. “Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy,” Aging (Albany NY). 2009 Jun 3;1(6):515-28. Baur JA, Sinclair DA. “Therapeutic potential of resveratrol: the in vivo evidence,” Nat Rev Drug Discov. 2006 5:493-506. Camins A, Sureda FX, Junyent F, Verdaguer E, Folch J, Pelegri C, Vilaplana J, Beas-Zarate C, Pallas M. “Sirtuin activators: designing molecules to extend life span,” Biochim Biophys Acta. 2010 Jun 23. Csaki C, Keshishzadeh N, Fischer K, Shakibaei M. “Regulation of inflammation signalling by resveratrol in human chondrocytes in vitro,” Biochem Pharmacol. 2008 Feb 1;75(3):677-87. Csaki C, Mobasheri A, Shakibaei M. “Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1beta-induced NF-kappaB- mediated inflammation and apoptosis,” Arthritis Res Ther. 2009;11(6):R165. Epub 2009 Nov 4. Hsieh TC, Wu, JM. “Resveratrol: Biological and pharmaceutical properties as anticancer molecule,” Biofactors. 2010 Jul 7. Kalantari H, Das DK. “Physiological effects of resveratrol,” Biofactors. 2010 Jul 7. Kraft TE, Parisotto D, Schempp C, Efferth T. “Fighting cancer with red wine? Molecular mechanisms of resveratrol, “Crit Rev Food Sci Nutr. 2009 Oct;49(9):782-99. Liu FC, Hung LF, Wu WL, Chang DM, Huang CY, Lai JH, Ho LJ. “Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondro- cytes,” Arthritis Res Ther. 2010;12(5):R167. Epub 2010 Sep 8.

Majumdar AP, Banerjee S, Nautiyal J, Patel BB, Patel V, Du J, Yu Y, Elliott AA, Levi E, Sarkar FH. “Curcumin synergizes with resveratrol to inhibit colon cancer,” Nutr Cancer. 2009;61(4):544-53. Manna SK, Mukhopadhyay A, Aggarwal BB. “Resveratrol suppresses TNF-induced acti- vation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation,” J Immunol. 2000 Jun 15;164(12):6509-19. Mikstacka R, Ignatowicz E. “Chemopreventive and chemotherapeutic effect of trans- resveratrol and its analogues in cancer,” Pol Merkur Lekarski. 2010 Jun 28(168):496-500. Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bernis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH. “Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes,” Nature. 2007 Nov 29;450(7170):712-6. Ramprasath VR, Jones PJ. “Anti-atherogenic effects of resveratrol,” Eur J Clin Nutr. 2010 Jul;64(7):660-8. Rascón B, Hubbard BP, Sinclair DA, Amdam GV. “The lifespan extension effects of res- veratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction,” Aging (Albany NY). 2012 Jul;4(7):499-508. Shakibaei M, Csaki C, Nebrich S, Mobasheri A. “Resveratrol suppresses interleukin-1beta- induced inflammatory signaling and apoptosis in human articular chondrocytes: potential for use as a novel nutraceutical for the treatment of osteoarthritis,” Biochem Pharmacol. 2008 Dec 1;76(11):1426-39. Shukla SK, Gupta S, Ojha SK, Sharma SB. “Cardiovascular friendly natural products: a promising approach in the management of CVD,” Nat Prod Res. 2010 May;24(9):873-98. Walle T, Hsieh F, DeLegge MH, Oatis JE Jr, Walle UK. “High absorption but very low bioavailability of oral resveratrol in humans,” Drug Metab Dispos. 2004 32:1377-1382. ROSEMARY Lee J, Jung E, Kim Y, Lee J, Park J, Hong S, Hyun CG, Park D, Kim YS. “Rosmarinic acid as a downstream inhibitor of IKK-beta in TNF-alfpha-induced upregulation of CCL11 and CCR3,” Br J Pharmacol. 2006 Jun;148(3):366-75. Shishodia S, Majumdar S, Banerjee S, Aggarwal BB. “Ursolic acid inhibitors nuclear factor- kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1,” Cancer Res. 2003 Aug 1;63(15):4375-83. SILYMARIN Ashkavand Z, Malekinejad H, Amniattalab A, Rezaei-Golmisheh A, Vishwanath BS. “Silymarin potentiates the anti-inflammatory effects of Celecoxib on chemically induced osteoarthritis in rats,” Phytomedicine. 2012 Aug 24. [Epub ahead of print] Malekinejad H, Rezabakhsh A, Rahmani F, Hobbenaghi R. “Silymarin regulates the cyto- chrome P450 3A2 and glutathione peroxides in the liver of streptozotocin-

induced diabetic rats,” Phytomedicine. 2012 May 15;19(7):583-90. Epub 2012 Mar 24. Manna SK, Mukhopadhyay A, Van NT, Aggarwal BB. “Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis,” J Immunol. 1999 Dec 15;163(12):6800-9. Saller R, Melzer J, Reichling J, Brignoli R, Meier R. “An updated systematic review of the pharmacology of silymarin,” Forsch Komplementmed. 2007 Apr;14(2):70-80. Epub 2007 Apr 23. Bibliography 337 338 Bibliography URSOLIC ACID Patha, K. “Ursolic acid inhibits STAT3 activation pathway leading to suppression of pro- liferation and chemo sensitization of human multiple myeloma cells,” Mol Can Res. 2007 Sept 5(9):943-55. Shishodia S. “Ursolic acid inhibits NFKB activation induced by carcinogenic agents through suppression of IkBalpha kinase and p65 phosphorylatin: correlation with down-regulation of COX2, MMP9 and Cyclin D1,” Can Res. 2003 63(15):4375-83. VITAMIN B6 and B Family Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (1998). National Academy of Sciences. Institute of Medicine. Food and Nutrition Board. Yanaka N, Koyama TA, Komatsu S, Nakamura E, Kanda M, Kato N. “Vitamin B6 sup- presses NF-kappaB activation in LPS-stimulated mouse macrophages,” Int J Mol Med. 2005 Dec;16(6):1071-5. VITAMIN C Pancorbo D, Vazquez C, Fletcher MA. “Vitamin C-lipid metabolites: uptake and retention and effect on plasma C-reactive protein and oxidized LDL levels in healthy volunteers,” Med Sci Monit. 2008;14(11):CR547-551. Son EW, Mo SJ, Rhee DK, Pyo S. “Vitamin C blocks TNF-alpha-induced NF-kappaB acti- vation and ICAM-1 expression in human neuroblastoma cells,” Arch Pharm Res. 2004 Oct;27(1):1073-9. Weeks BS, Perez PP. “Absorption rates and free radical scavenging values of vitamin C-lipid metabolites in human lymphoblastic cells,” Med Sci Monit. 2007 Oct;13(10):BR205-10. VITAMIN D Aubert G, Lansdorp PM. Telomeres and Aging. Physiol. Rev. 2008;88:557–579. Cannell J. The Athlete’s Edge: Quicker, Stronger, Faster With Vitamin D. Here & Now Books, 2011. Cohen-Lahav M, Shany S, Tobvin D, Chaimovitz C, Douvdevani A. “Vitamin D decreases NFkappaB activity by increasing IkappaBalpha levels,” Nephrol Dial Transplant. 2006 Apr;21(4):889-97. Cranney A, Horsley T, O’Donnell S, Weiler H, Puil L, Ooi D, Atkinson S, Ward L, Moher D, Hanley D, Fang M, Yazdi F, Garritty C, Sampson M, Barrowman N, Tsertsvadze A, Mamaladze V. “Effectiveness and safety of vitamin D in relation to bone health,” Evid Rep Technol Assess (Full Rep). 2007 Aug;(158):1-235.

Heaney RP. “What Is Vitamin D Insufficiency? And Does It Matter?” Calcif Tissue Int. 2012 May 15. [Epub ahead of print] Heaney RP. “Vitamin D--baseline status and effective dose,” N Engl J Med. 2012 Jul 5;367(1):77-8. Holick MF. “Vitamin D deficiency,” N Engl J Med. 2007 Jul 19;357(3):266-81. Richards JB, Valdes AM, Gardner JP, Paximadas D, Kimura M, N “H igher serum vitamin D concentrations are associated with longer leukocyte telomere length in women,” Am J Clin Nutr. 2007 Nov;86(5):1420-5. Zadshir A, Tareen N, Pan D, Norris K, Martins D. “The prevalence of hypovitaminosis D among US adults: data from the NHANES III,” Ethn Dis. 2005 Autumn; 15(4Suppl 5): S5-97-101. VITAMIN E Ahn KS, Sethi G, Krishnan K, Aggarwal BB. “Gamma-tocotrienol inhibits nuclear factor- kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis,” J Biol Chem. 2007 Jan 5;282(1):809-20. Glauert HP. “Vitamin E and NF-kappaB activation: a review,” Vitam Horm. 2007 76:135-53. Wu SJ, Liu PL, Ng LT. “Tocotrienol-rich fraction of palm oil exhibits anti-inflammatory property by suppressing the expression of inflammatory mediators in human monocytic cells,” Mol Nutr Food Res. 2008 Aug;52(8):921-9. CHAPTER 5 Move: How Exercise Helps You Move Better and Feel Better Billat VL, Slawinski J, Bocquet V, Demarle A, Lafitte L, Chassaing P, Koralsztein JP. “Intermittent runs at the velocity associated with maximal oxygen uptake enables sub- jects to remain at maximal oxygen uptake for a longer time than intense but submaximal runs,” Eur J Appl Physiol. 2000 Feb;81(3):188-96. Buford TW, Cooke MB, Manini TM, Leeuwenburgh C, Willoughby DS. “Effects of Age and Sedentary Lifestyle on Skeletal Muscle NF-kB Signaling in Men,” J Gerolontology 2009 Vol 65A(5) p. 532-37. Burke J, Thayer R, Belcamino M. “Comparison of effects of two interval-training pro- grammes on lactate and ventilatory thresholds,” Br J Sports Med. 1994 Mar;28(1):18-21. Carlsen H, Haugen F, Zadelaar S, Kleemann R, Kooistra T, Drevon CA, Blomhoff R. “Diet- induced obesity increases NF-kappaB signaling in reporter mice,” Genes Nutr. 2009 Sep;4(3):215-22. Epub 2009 Aug 26. Chai DH, Arner EC, Griggs DW, Grodzinsky AJ. “Alphav and beta1 integrins regulate dynamic compression-induced proteoglycan synthesis in 3D gel culture by distinct com- plementary pathways,” Osteoarthritis Cartilage. 2010 Feb;18(2):249-56. Epub 2009 Sep 22. Cheng YJ, Imperatore G, Caspersen CJ, Gregg EW, Albright AL, Helmick CG. Prevalence of Diagnosed Arthritis and Arthritis-Attributable Activity Limitation Among Adults With and Without Diagnosed Diabetes: United States, 2008-2010. Diabetes Care. 2012;35:1686-1691

Clement K, Langin D. “Regulation of inflammation-related genes in human adipose tissue,” J Intern Med. 2007 Oct;262(4):422-30. Duncker DJ, Bache RJ “Regulation of coronary blood flow during exercise,” Physiol Rev. 2008 Jul;88(3):1009-86. Bibliography 339 340 Bibliography Holloszy JO, Kohrt WM, Hansen PA. “The regulation of carbohydrate and fat metabolism during and after exercise,” Front Biosci. 1998 Sep 15;3:D1011-27. Kim W, Thambyah A, Broom N. “Does prior sustained compression make cartilage-on- bone more vulnerable to trauma?” Clin Biomech (Bristol, Avon). 2012 Aug;27(7):637-45. Epub 2012 Apr 24. Kisiday JD, Jin M, DiMicco MA, Kurz B, Grodzinsky AJ. “Effects of dynamic compressive loading on chondrocyte biosynthesis in self-assembling peptide scaffolds,” J Biomech. 2004 May;37(5):595-604. Lee DA, Noguchi T, Frean SP, Lees P, Bader DL. “The influence of mechanical loading on isolated chondrocytes seeded in agarose constructs,” Biorheology. 2000;37(1-2):149-61. Mauck RL, Soltz MA, Wang CC, Wong DD, Chao PH, Valhmu WB, Hung CT, Ateshian GA. “Functional tissue engineering of articular cartilage through dynamic loading of chondro- cyte-seeded agarose gels,” J Biomech Eng. 2000 Jun;122(3):252-60. Perry CG, Heigenhauser GJ, Bonen A, Spriet LL. “High-intensity aerobic interval training increases fat and carbohydrate metabolic capacities in human skeletal muscle,” Appl Physiol Nutr Metab. 2008 Dec;33(6):1112-23. Pingguan-Murphy B, Nawi I. “Upregulation of matrix synthesis in chondrocyte- seeded agarose following sustained bi-axial cyclic loading,” Clinics (Sao Paulo). 2012 Aug;67(8):939-44. Salter RB. “The biologic concept of continuous passive motion of synovial joints. The first 18 years of basic research and its clinical application,” Clin Orthop Relat Res. 1989 May;(242):12-25. Smith LR, Trindade MC, Ikenoue T, Mohtai M, Das P, Carter DR, Goodman SB, Schurman DJ. “Effects of shear stress on articular chondrocyte metabolism,” Biorheology. 2000;37(1-2):95-107. Smith RL, Carter DR, Schurman DJ. “Pressure and shear differentially alter human articular chondrocyte metabolism: a review,” Clin Orthop Relat Res. 2004 Oct;(427 Suppl):S89-95. Talanian JL, Galloway SC, Heigenhauser GJ, Bonen A, Spriet LL. “Two weeks of high- intensity aerobic interval training increases the capacity for fat oxidation during exercise in women,” J Appl Physiol. 2007 Apr;102(4):1439-47. Thomas J. LaRocca, Douglas R. Seals,* and Gary L. Pierce. Leukocyte Telomere Length is Preserved with Aging in Endurance Exercise-Trained Adults and Related to Maximal Aerobic Capacity. Mech Ageing Dev. 2010 February; 131(2): 165–167. Tremblay A, Simoneau JA, Bouchard C (1994). “Impact of exercise intensity on body fat- ness and skeletal muscle metabolism”. Metabolism: Clinical and Experimental 43 (7): 814–8.

Uzel SG, Buehler MJ. “Molecular structure, mechanical behavior and failure mechanism of the C-terminal cross-link domain in type I collagen.” J Mech Behav Biomed Mater. 2011 Feb;4(2):153-61. Epub 2010 Jul 16. Wolfe RR. “Fat metabolism in exercise,” Adv Exp Med Biol. 1998 441:147-56. Appendix 1 See Chapter 4 for additional supplement information Adcocks C, Collin P, Buttle DJ. Catechins from green tea (Camellia sinensis) inhibit bovine and human cartilage proteoglycan and type II collagen degradation in vitro. J Nutr. 2002 Mar;132(3):341-6. Ahmed 2000, 2008 see Chapter 4 Aktan see Chapter 4 Ashkavand see Chapter 4 Bagga D, Wang L, Farias-Eisner R, Glaspy J. Reddy ST. Differential effects of prostaglandin derived from x-6 and w-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion. PNAS. 2003 Feb;100(4):1751-56. Bianco FJ, Guitian R, Moreno J, de Toro FJ, Galdo F. Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes. J Rheumatol. 1999 26:1366-1373. Champ PC, Harvey, RA. Lippincott’s Illustrated Reviews: Biochemistry 2nd edition. 1994 Lippincott Williams & Wilkins. Chung HY, Kim HJ, Kim JW, Yu BP. The inflammation hypothesis of aging: molecular modulation by calorie restriction. Ann NY Acad Sci. 2001 Pri; 928:327-35. Clandinin MT, Foot M,Robson. Plasma membrane: Can its structure and function be modulated by dietary fat? Comparative Biochemistry and Physiology Part B: Comparative Biochemistry. 1983: (76) issue 2: 335-339. Csaki see Chapter 4 Fan YY, Ly LH, Barhoumi R, McMurray DN, Chapkin RS. Dietary docosahexaenoic acid suppresses T cell protein kinase C theta lipid raft recruitment and IL-2 production. J Immunol. 2004 Nov 15;173(10):6151-60. Go see Chapter 4 Goldring, Mary B., Berenbaum, Francis. The Regulation of Chondrocyte Function by Proinflammatory Mediators. Clin Ortho and Related Research. 2004 Number 427S, pp. S37-S46. Hou DX, Luo D, Tanigawa S, Hashimoto F, Uto T, Masuzaki S, Fujii M, Sakata Y. Prodelphinidin B-4 3'-O-gallate, a tea polyphenol, is involved in the inhibition of COX-2 and iNOS via the downregulation of TAK1-NF-kappaB pathway. Biochem Pharmacol. 2007 Sep 1;74(5):742-51. Epub 2007 Jun 14. Hwang DH, Chanmugam PS, Ryan DH, Boudreau MD, Windhauser MM, Tulley RT, Brooks ER, Bray GA. Does vegetable oil attenuate the beneficial effects of fish oil in reducing risk factors for cardiovascular disease? Am J Clin Nutr. 1997 Jul;66(1):89-96. Ichikawa H, Aggarwal BB. Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by

suppressing nuclear factor-kappaB ctivation. Clin Cancer Res. 2006 Jan 15;12(2):662-8. Ishiguro K, Ando T, Maeda O, Ohmiya N, Niwa Y, Kadomatsu K, Goto H. Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms. Biochem Biophys Res Commun. 2007 Oct 12;362(1):218-23. Epub 2007 Aug 10. Kakkar P, Singh BK. Mitochondria: a hub of redox activities and cellular distress control. Mol Cell Biochem. 2007 Nov;305(1-2):235-53. Epub 2007 Jun 12. Kris-Etherton PM, Grieger JA, Etherton TD. Dietary reference intakes for DHA and EPA. Prostaglandins Leukot Essent Fatty Acids. 2009 Aug-Sep;81(2-3):99-104. Kwon HM, Choi YJ, Choi JS, Kang SW, Bae JY, Kang IJ, Jun JG, Lee SS, Lim SS, Kang YH. Blockade of cytokine-induced endothelial cell adhesion molecule expression by licorice isoliquiritigenin through NF-kappaB signal disruption. Exp Biol Med (Maywood). 2007 Feb;232(2):235-45. Li B, Birdwell C. Antithetic Relationship of Dietary Arachidonic Acid and EPA on Eicosanoid Production in Vivo. J Lipid Sea October 1994 35(10A) 1869-77. Li JJ, Gao RL. Should atherosclerosis be considered a cancer of the vascular wall? Med Hypotheses. 2005;64(4):694-8. Li Q, Withoff S, Verma IM. Inflammation-associated cancer: NF-kappaB is the lynchpin. Trends Immunol. 2005 Jun;26(6):318-25. Li BY, Li XL, Gao HQ, Zhang JH, Cai Q, Cheng M, Lu M. Grape seed procyanidin B2 inhibits advanced glycation end product-induced endothelial cell apoptosis through regulating GSK3β phosphorylation. Cell Biol Int. 2011 Jul;35(7):663-9. Liu FC, Hung LF, Wu WL, Chang DM, Huang CY, Lai JH, Ho LJ. Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytes. Arthritis Res Ther. 2010;12(5):R167. Epub 2010 Sep 8. Lopez-Armada MJ, Carames B, Martin MA, Cillero-Pastor B, Lires-Dean M, Fuentes-Boquete I, Arenas J. Bianco, FJ. Mitochondrial activity is modulated by TNFalpha and IL-1beta in normal human chondrocyte cells. Osteoarthritis Cartilage. 2006 Oct;14(10):1011-22. Epub 2006 May 5. Lv see Chapter 4 Malekinejad H, Rezabakhsh A, Rahmani F, Hobbenaghi R. Silymarin regulates the cytochrome P450 3A2 and glutathione peroxides in the liver of streptozotocin-induced diabetic rats. Phytomedicine. 2012 May 15;19(7):583-90. Epub 2012 Mar 24. Manna see Chapter 4 MCcAnn SM, Mastronardi C, de Laurentiis A., Rettori V.The Nitric Oxide Theory of Aging Revisited. Ann NY Acad Sci. 2005 Dec;1057:64-84. Milne JC see Chapter 4 Monfort J, Martel-Pelletier J, Pelletier JP. Chondroitin sulphate for symptomatic osteoarthritis: critical appraisal of meta-analyses. Curr Med Res Opin. 2008 May;24(5):1303-8.

Moussaieff A, Shohami E, Kashman Y, Fride E, Schmitz ML, Renner F, Fiebich BL, Munoz E, Ben-Neriah Y, Mechoulam R. Incensole Acetate, a Novel anti-inflammatory compound isolated rom Boswellia Resin, Inhibits nuclear factor (NF)-kappa B activation. Mol Pharmacol. 2007 Sep 26. Neelands PJ, Clandinin MT. Diet fat influences liver plasma membrane lipid composition and glucagon-stimulated adenylate cyclase activity. Biochem J. 1983: (212): 573-583. Orrenius S. Reactive oxygen species in mitochondria-mediated cell death. Drug Metab Rev. 2007;39(2-3):443-55. Orrenius S, Gogvadze V, Zhivotovsky B. Mitochondrial oxidative stress: implications for cell death. Ann Rev Pharmacol Toxicol.2007;47:143-83. Ottestad I, Hassani S, Borge GI, Kohler A, Vogt G, Hyötyläinen T, Orešič M, Brønner KW, Holven KB, Ulven SM, Myhrstad MC. Fish Oil Supplementation Alters the Plasma Lipidomic Profile and Increases Long-Chain PUFAs of Phospholipids and Triglycerides in Healthy Subjects. PLoS One. 2012;7(8):e42550. Epub 2012 Aug 28. Pae HO, Jeong SO, Kim HS, Kim SH, Song YS, Kim SK, Chai KY, Chung HT. Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-kappaB activation in RAW264.7 macrophages activated with LPS. Mol Nutr Food Res. 2008 Sep;52(9):1082-91. Pavelka, K, Gatterova J, Olejarova M, Machacek S, Giacovelli G, Rovati LC. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year randomized, placebo-controlled, double-blind study. Arch Intern Med. 2002 Oct 14;162(18):2113-23. Raheed see Chapter 4 Richards JB, Valdes AM, Gardner JP, Paximadas D, Kimura M, N igher serum vitamin D concentrations are associated with longer leukocyte telomere length in women. Am J Clin Nutr. 2007 Nov;86(5):1420-5. Roskoski R Jr, Herbert JD. Biochemistry review. 1996, Saunders. Roy S, Khanna S, Krishnaraju AV, Subbaraju GV, Yasmin T, Bagchi D, Sen CK. Regulation of vascular responses to inflammation: inducible matrix metalloproteinase-3 expression in human microvascular endothelial cells is sensitive to antiinflammatory Boswellia. Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):653-60. Sarris J, Kavanagh DJ, Byrne G, Bone KM, Adams J, Deed G. The Kava Anxiety Depression Spectrum Study (KADSS): a randomized, placebo-controlled crossover trial using an aqueous extract of Piper methysticum. Psychopharmacology (Berl). 2009 Aug;205(3):399-407. Epub 2009 May 9. Sawitzke see Chapter 4 Scholtissen S, Bruyere O, Neuprez A, Severens JL, Herrero-Beaumont G, Rovati L, Hiligsmann M, Reginster JY. Glucosamine sulphate in the treatment of knee osteoarthritis: cost-effectiveness comparison with paracetamol. Int J Clin Pract. 2010 64(6):756-762. Shishodia see Chapter 3

Siemoneit U, Hofmann B, Kather N, Lamkemeyer T, Madlung J, Franke L, Schneider G, Jauch J, Poeckel D, Werz O. Identification and functional analysis of cyclooxygenase-1 as a molecular target of boswellic acids. Biochem Pharmacol. 2008 Jan 15;75(2):503-13. Epub 2007 Sep 14. Sirhan C N, Arita M, Hong S and Gotlinger K. Resolvins, Docosatrienesx, and Neuroprotectins, Novel Omega-3-Derived Mediators, and Their Endogenous Aspirin-Triggered Epimers. Lipids. 2004 39 (11) 1125-1132. Takada Y, Bhardwaj A, Potdar P, Aggarwal BB. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kabbaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene. 2004 Dec 9;23(57):9247-58. Terkeltaub R, Johnson K, Murphy A. Ghosh S. Invited review: the mitochondrion in osteoarthritis. Mitochondrion. 2002 Feb;1(4):301-19. Teschke R, Genthner A, Wolff A. Kava hepatotoxicity: comparison of aqueous, ethanolic, acetonic kava extracts and kava-herbs mixtures. J Ethnopharmacol. 2009 Jun 25;123(3):378-84. Epub 2009 Apr 5. Teschke R, Sarris J, Schweitzer I. Kava hepatotoxicity in traditional and modern use: the presumed Pacific kava paradox hypothesis revisited. Br J Clin Pharmacol. 2012 Feb;73(2):170-4. doi: 10.1111/j.1365-2125.2011.04070.x. Uebelhart D. Clinical review of chondroitin sulfate in osteoarthritis. Osteoarthritis Cartilage. 2008 16 Suppl 3:S19-21. Wilcox RB. High Yield Biochemistry. 1999, Lippincott Williams & Wilkins. Yin MJ, Yamamoto Y, Gaynor RB. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa) B kinase-beta. Nature. 1998 Nov 5;396(6706):77-80. Appendix 2 Live: The Bonus Effects of the Joint Health for Life Lifestyle Abbruzzese JL, Lippman SM. “The convergence of cancer prevention and therapy in early- phase clinical drug development,” Cancer Cell. 2004 6:321-326. Aggarwal BB. “Nuclear factor-kB: the enemy within,” Cancer Cell. 2004 6:203-208. Aggarwal BB, Shishodia S. “Molecular targets of dietary agents for prevention and therapy of cancer,” Biochem Pharmacol. 2006 71:1397-1421. Aggarwal S, Takada Y, Singh S, Myers JN, Aggarwal BB. “Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kapaB signaling,” Int J Cancer. 2004 111:679-692. Armour SM, Baur JA, Hsieh SN, Land-Bracha A, Thomas Sm, Sinclair DA. “Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy,” Aging (Albany NY). 2009 Jun 3;1(6):515-28. Arterburn LM, Hall EB, Oken H. Distribution, interconversion, and dose response of n-3 fatty acids in humans. Am J Clin Nutr. 2006 Jun;83(6 Suppl):1467S-1476S.

Bagga D, Wang L, Farias-Eisner R, Glaspy JA, and Reddy ST. “Differential effects of pros- taglandin derived from Omega 6 and Omega 3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion,” PNAS Feb 18, 2003 100(4) 1751-56. Basch E, Boon H. Davies-Heerema T, Foppo I, Hashmi S, Hasskarl J, Sollars D, Ulbricht C. “Boswellia: an evidence based systematic review by the Natural Standard Research Collaboration,” J Herb Pharmacother. 2004 4(3):63-83. Baur JA, Sinclair DA. “Therapeutic potential of resveratrol: the in vivo evidence,” Nat Rev Drug Discov. 2006 5:493-506. Bhardwaj A, Sethi G, Vadhan-Raj S, Bueso-Ramos C, Takada Y, Guar U, Nair AS, Shishodia S, Aggarwal BB. “Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells,” Blood. 2007 109:2293-2302. Bharti AC, Donato N, Singh S, Aggarwal BB. “Curcumin (diferuloylmethane) down-reg- ulates the constitutive activation of nuclear factor kB and IkBa kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis,” Blood 2003. 101:1053-1062. Bingham SA, Pignatelli B, Pollock JR, Ellul A, Malaveille C, Gross G, Runswick S, Cummings JH, O’Neill IK. “Does increased endogenous formation of N-nitroso compounds in the human colon explain the association between red meat and colon cancer? Carcinogenesis. 1996 Mar;17(3):515-23. Brace LD. Cardiovascular benefits of garlic (Allium sativum L). J Cardiovasc Nurs. 2002 Jul;16(4):33-49. Cao J, Schwichtenberg KA, Hanson NQ, Tsai MY. Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids. Clin Chem. 2006 Dec;52(12):2265-72. Epub 2006 Oct 19. Csisar A, Wang M, Lakatta EG, Ungvari Z. “Inflammation and endothelial dysfunction during aging: role of NF-kB,” J Appl Physiol. 2008 105:1333-1341. Cui H, He ZY. “Effects of dry red wine on experimental atherosclerosis in rabbits,” Zhonghua Yu Fang Yi Xue Za Zhi. 2004 Mar;38(2):103-6. Bibliography 341 342 Bibliography Daley CA, Abbott A, Doyle PS, Nader GA, Larson S. “A review of fatty acid profiles and antioxidant content in grass-fed and grain-fed beef,” Nutr Journ 2010 10;9:10. Denkins Y, Kempf D, Ferniz M. Nileshwar S, Marchetti D. “Role of [omega]-3 polyunsatu- rated fatty acids on cyclooxygenase-2 metabolism in brain-metastatic melanoma,” Jour of lipid Res. 2005 June 46(6):1278-1284. Ding EL, Hutfless SM, Ding X, Girotra S. “Chocolate and prevention of cardiovascular disease: a systematic review,” Nutr Metab (Lond). 2006 Jan 3;3:2. Ditsworth D, Zong WX. “NF-kappaB: key mediator of inflammation-associated cancer,” Cancer Biol Ther. 2004 Dec;3(12):1214-6. Epub 2004 Dec 15. Review. Duncker DJ, Bache RJ “Regulation of coronary blood flow during exercise,” Physiol Rev. 2008 Jul;88(3):1009-86.

Emelyanov A, Fedoseev G, Krasnoschekova O, Abulimity A, Trendeleva T, Barnes PJ. “Treatment of asthma with lipid extract of New Zealand green-lipped mussel: a random- ized clinical trial,” Eur Respir J. 2002 20:596-600. Fradet, Vincent, Cheng, Iona, Casey, Graham, Witte John S. “Dietary Omega-3 Fatty Acids, Cyclooxygenase-2 Genetic Variation, and Aggressive Prostate Cancer Risk,” Clinical Cancer Research (24 March 2009). Fuehrlein BS, Rutenberg MS, Silver JN, Warren MW, Theriaque DW, Duncan GE, Stacpoole PW, Brantly ML. “Differential metabolic effects of saturated versus polyunsaturated fats in ketogenic diets,” Clin Endoc & Metab. 2004 89(4):1641-1645. Gebauer SK, Psota TL, Harris WS, Kris-Etherton PM. “N-3 fatty acid dietary recommen- dations and food sources to achieve essentiality and cardiovascular benefits,” Am J Clin Nutr. 2006 Jun;83(6 Suppl):1526S-1535S. Goto S, Naito H, Kaneko T, Chung HY, Radak Z. “Hormetic effects of regular exercise in aging: correlation with oxidative stress,” Appl Physiol Nutr Metab. 2007 Oct;32(5):948-53. Hanai H, Sugimoto K. “Curcumin has bright prospects for the treatment of inflammatory bowel disease,” Curr Pharm Des. 2009 15(18):2087-94 Harbige LS. “Fatty acids, the immune response, and autoimmunity: a question of n-6 essentiality and the balance between n-6 and n-3,” Lipds. 2003 Apr;38(4):323-41. Hostanska K, Daum G, Saller R. “Cystostatic and apoptosis-inducing activity of boswellic acids toward malignant cell lines in vitro,” Anticancer Res. 2002 Sep-Oct;22(5):2853-62. Howard BV, Van Horn L, Hsia J, Manson JE, Stefanick ML, Wassertheil-Smoller S, Kuller LH, LaCroix AZ, Langer RD, Lasser NL, Lewis CE, Limacher MC, Margolis KL, Mysiw WJ, Ockene JK, Parker LM, Perri MG, Phillips L, Prentice RL, Robbins J, Rossouw JE, Sarto GE, Schatz IJ, Snetselaar LG, Stevens VJ, Tinker LF, Trevisan M, Vitolins MZ, Anderson GL, Assaf AR, Bassford T, Beresford SA, Black HR, Brunner RL, Brzyski RG, Caan B, Chlebowski RT, Gass M, Granek I, Greenland P, Hays J, Heber D, Heiss G, Hendrix SL, Hubbell FA, Johnson KC, Kotchen JM. “Low-fat dietary pattern and risk of cardiovascular disease: the Women’s Health Initiative Randomized Controlled Dietary Modification Trial,” JAMA. 2006 Feb 8;295(6):655-66. Hunter JE, Zhang J, Kris-Etherton PM. Cardiovascular disease risk of dietary stearic acid compared with trans, other saturated, and unsaturated fatty acids: a systematic review. Am J Clin Nutr. 2010 Jan;91(1):46-63. Hsieh TC, Wu, JM. Resveratrol: Biological and pharmaceutical properties as anticancer molecule. Biofactors. 2010 Jul 7. Ichikawa H, Aggarwal BB. “Guggulsterone inhibits osteoclastogenesis induced by recep- tor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB ctivation,” Clin Cancer Res. 2006 Jan 15;12(2):662-8. Jenkins DJA, Wong JMW, Kendall CWC, Esfahani A, Ng VWY, Leong TCK, Faulkner DA, Vidgen E, Greaves KA, Paul G, etal. “The Effects of a Plant-Based Low-

Carbohydrate(“Eco- Atkins”) Diet on Body Weight and Blood Lipid Concentrations in Hyperlipidemic Subjects,” Arch Intern Med, June 8, 2009; 169(11):1046-1054. Jurenka JS. “Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research,” Altern Med Rev. 2009 Jun;14(2):141-53. Kakkar P, Singh BK. “Mitochondria: a hub of redox activities and cellular distress control,” Mol Cell Biochem. 2007 Nov;305(1-2):235-53. Epub 2007 Jun 12. Kalantari H, Das DK. “Physiological effects of resveratrol,” Biofactors. 2010 Jul 7. Kenfield S, Meir J, Stampfer M, Giovannucci E and Chan J. Physical Activity and Survival After Prostate Cancer Diagnosis in the Health Professionals Follow-Up Study. J Clin Oncol. 2011 February 20; 29(6): 726–732. Kim EHJ, Willett WC, Colditz GA, Hankinson SE, Stampfer MJ, Hunter DJ, Rosner B, and Holmes MD. “Dietary Fat and Risk of Postmenopausal Breast Cancer in a 20-year follow up,” Am J Epidemiol. November 15, 2006; 164(10):990-997. Kown GT, Cho HJ, Chung WY, Park KK, Moon A, Park JH. Isoliquiritigenin inhibits migration and invasion of prostate cancer cells: possible mediation by decreased JNK/AP-1 signaling. J Nutr Biochem. 2009 Sep;20(9):663-76. Lee KW, Kundu JK, Sim SO, Chun KS, Lee HJ, Surh YJ. “Cocoa polyphenols inhibit phor- bol ester-induced superoxide anion formation in cultured HL-60 cells and expression of cyclooxygenase-2 and activation of NJ-kappaB and MAPKs in mouse skin in vivo,” J Nutr. 2006 May;136(5):1150-5. Leung FP, Yung LM, Laher I, Yao X, Chen ZY, Huang Y. “Exercise, vascular wall and cardiovascular diseases: an update (Part 1),” Sports Med. 2008;38(12):1009-24. doi: 10.2165/00007256-200838120-00005. Li JJ, Gao RL. “Should atherosclerosis be considered a cancer of the vascular wall?” Med Hypotheses. 2005;64(4):694-8. Li Q, Withoff S, Verma IM. “Inflammation-associated cancer: NF-kappaB is the lynchpin,” Trends Immunol. 2005 Jun;26(6):318-25. Liu JJ, Nilsson A, Oredsson S, Badmaev V, Zhao WZ, Duan RD. “Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells,” Carcinogenesis. 2002 Dec;23(12):2087-93. Lowe JM, Hyukjin C, Qian Y. Fornace AJ. “Nuclear Factor-kB (NF-kB) Is a Novel Positive Transcriptional Regulator of the Oncogenic Wip1 Phosphatase,” Jour of Bio. Chemistry. 2010 Feb, 19(285):5249-5257. Ma H, Wang J, Wang J, Li Y, Li J. “Fish oil ameliorates the allograft arteriosclerosis of intestine on rats,” Pediatr Transplant. 2007 Mar;11(2):173-9. Massaro M, Habib A, Lubrano L, Del Turco S, Lazzerini G, Bourcier T, Weksler BB, De Caterina R. “The omega-3 fatty acid docosahexaenoate attenuates endothelial Bibliography 343 344 Bibliography cyclooxygenase-2 induction through both NADP(H) oxidase and PKC_ inhibition,” PNAS. 2006 July.

Mente A, de Koning L, Shannon HS, Anand SS. “A Systematic Review of the Evidence Supporting a Causal Link Between Dietary Factors and Coronary Heart Disease,” Arch Intern Med, April 13, 2009;169(7):659-669. Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bernis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH. “Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes,” Nature. 2007 Nov 29;450(7170):712-6. Mozaffarian D, Rimm EB, Herrington DM. “Dietary fats, carbohydrate, and progres- sion of coronary atherosclerosis in postmenopausal women,” Am J Clin Nutr. 2004 Nov;80(5):1175-84. Mozaffarian D, Katan MB, Ascherio A, Stampfer MJ, Willett WC. “Trans fatty acids and cardiovascular disease,” N Engl J Med. 2006 Apr 13;354(15):1601-13. Myers J, Prakash M, Froelicher V, etal. Exercise capacity and mortality among men referred for exercise testing. N Engl Med. 2002 346:793-801. Myers, J. Exercise and Cardiovascular Health. Circulation. 2003 107:e2. Nagakura T, Matsuda S, Shichijyo K, Sugimoto H, Hata K. “Dietary supplementation with fish oil rich in omega-3 polyunsaturated fatty acids in children with bronchial asthma,” Eur Respir J. 2000 16:861-865. Norat T et al. “Meat, Fish, and Colorectal Cancer Risk: The European Prospective Investigation into Cancer and Nutrition,” JNCI J Natl Cancer Inst (15 June 2005) 97 (12): 906-916. Orrenius S, Gogvadze V, Zhivotovsky B. “Mitochondrial oxidative stress: implications for cell death,” Annu Rev Pharmacol Toxicol.2007;47:143-83. Ross JS, Stagliano NE, Donovan MJ, Breitbart RE, Ginsburg GS. “Atherosclerosis: a cancer of the blood vessels?” Am J Clin Pathol. 2001 Dec;116 Suppl:S97-107. Review. Ross JS, Stagliano NE, Donovan MJ, Breitbart RE, Ginsburg GS. “Atherosclerosis and can- cer: common molecular pathways of disease development and progression,” Ann N Y Acad Sci. 2001 Dec;947:271-92; discussion 292-3. Saha A, Kuzuhara T, Echigo N, Suganuma M, Fujiki H. New role of (-)-Epicatechin in enhancing the induction of growth inhibition and apoptosis in human lung cancer cells by curcumin. Cancer Prev Res (Phila Pa). 2010 July 6. Shisho, Aggarwal BB. “Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activa- tion suppresses expression of anti-apoptotic gene products, and enhances apoptosis,” J Biol Chem. 2004 Nov 5;279(45):47148-58.dia S, Sikora E, Bielak-Zmijewska A, Mosieniak G, Piwocka K. “The promise of slow down ageing may come from curcumin,” Curr Pharm Des. 2010;16(7):884-92. Singh S, Khar A. “Biological effects of curcumin and its role in cancer chemoprevention and therapy,” Anticancer Agents Med Chem. 2006 6:259-270. Sonestedt, Emily; Ericson, Ulrika; Gullberg, Bo; Skog, Kerstin; Olsson, Håkan; Wirfält, Elisabet (2008). “Do both heterocyclic amines and omega-6 polyunsaturated fatty acids contribute to the incidence of breast cancer in postmenopausal women of the Malmö diet and cancer cohort?” The International Journal of Cancer (UICC International Union Against Cancer) 123 (7): 1637–1643.

Stampfer MF, Hu FB, Manson JE, Rimm EB, Willett WC. Primary prevention of coronary heart disease in women through diet and lifestyle. N Engl J Med. 2000 Jul 6;343(1):16-22. Sukumaran S, Pittman KB, Patterson WK, Dickson J, Yeend S, Townsend A, Broadbridge V, Price TJ. “A phase I study to determine the safety, tolerability and maximum tolerated dose of green-lipped mussel (Perna canaliculus) lipid extract, in patients with advanced prostate and breast cancer,” Annals of Oncology. Doi:10.1093. Takada Y, Bhardwaj A, Potdar P, Aggarwal BB. “Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kabbaB activation, inhibition of expression of cyclo- oxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation,” Oncogene. 2004 Dec 9;23(57):9247-58. Vidal-Vanaclocha F. “Inflammation in the molecular pathogenesis of cancer and athero- sclerosis,” Reumatol Clin. 2009 Apr;5S1:40-3. Epub 2009 Apr 2. Vidgren HM, Agren JJ, Schwab U, Rissanen T, Hänninen O, Uusitupa MI. Incorporation of n-3 fatty acids into plasma lipid fractions, and erythrocyte membranes and platelets during dietary supplementation with fish, fish oil, and docosahexaenoic acid-rich oil among healthy young men. Lipids. 1997 Jul;32(7):697-705. Virtanen JK, Mozaffarian D, Chiuve SE, Rimm EB. “Fish consumption and risk of major chronic disease in men. Am J Clin Nutr. 2008 Dec;88(6):1618-25. Wang YT, Wang J, Zhao M, DI HJ. [Inhibitory effects of reduced glutathione sodium on renal nuclear factor-kappaB expression in rats with diabetes of different stages]. Nan Fang Yi Ke Da Xue Xue Bao. 2007 Mar;27(3):332-5. Wang P, Aronson WJ, Huang M, Zhang Y, Lee RP, Heber D, Henning SM. Green Tea polyphenols and metabolites in Prostatectomy Tissue: implications for cancer prevention. Cancer Prev Res (Phila Pa). 2010 Jul 13. Wolin KY, Yan Y, Colditz GA, Lee I-M. Physical activity and colon cancer prevention: a meta-analysis. Brit J of Cancer. 2009 100, 611-616. Wyshak G, Frisch RE. Breast cancer among former college athletes compared to non-athletes: a 15-year follow-up. Br J Cancer. 2000 Feb; 82(3):726-30. Xu J, Eilat-Adar S, Loria C, Goldbourt U, Howard BV, Fabsitz RR, Zephier EM, Mattil C, and Lee ET. “Dietary fat intake and risk of coronary heart disease: the Strong Heart Study,” Am J Clinical Nutrition, Oct 1, 2006;84(4):894-902. Xu L, Li B, Cheng M, Zhang W, Pan J, Zhang C, Gao H. “Oral administration of grape seed proanthocyanidin extracts downregulate RAGE dependant nuclear factor-kappa BP65 expression in the hippocampus of streptozotocin induced diabetic rats,” Exp Clin Endocrinol Diabetes. 2008 Apr;116(4):215-24. Yates A, Norwig J, Maroon J, Bost J, Bradley JP, Duca M, Wecht D, Grove R, Iso A, Cobb I, Ross N, Borden M. “Evaluation of Lipid Profiles and the Use of Omega-3 Essential Fatty Acid in Professional Football Players,” Sports Health: A Multidisciplinary Approach 2009 Jan 1;(1):21-30. Yung LM, Laher I, Yao X, Chen ZY, Huang Y, Leung FP. “Exercise, vascular wall and cardiovascular diseases: an update (part 2),” Sports Med. 2009;39(1):45-63. doi: 10.2165/00007256-200939010-00004.

Zahid M, Saeed M, Ali MF, Rogan EG, Cavalieri EL. N-acetylcysteine blocks formation of cancer-initiating estrogen-DNA adducts in cells. Free Radic Biol Med. 2010 Aug 1;49(3):392-400. HEART Ascherio A, Rimm EB, Giovannucci EL, Spiegelman D, Stampfer M, Willett WC. “Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States,” BMJ. 1996 Jul 13;313(7049):84-90. Auvichayapat P, Prapochanung M, Tunkamnerdthai O, Sripanidkulchai BO, Auvichayapat N, Thinkhamrop B, Kunhasura S, Wongpratoom S, Sinawat S. Hongprapas P. “Effectiveness of green tea on weight reduction in obese Thais: A randomized, controlled trial,” Physiol Behav. 2008 Feb 27;93(3):486-91. Bibliography 345 346 Bibliography Basu A, Penugonda K. “Pomegranate juice: a heart-healthy fruit juice,” Nutr Rev. 2009 Jan;67(1):49-56. Baur JA, Sinclair DA. “Therapeutic potential of resveratrol: the in vivo evidence,” Nat Rev Drug Discov. 2006 Jun;5(6):493-506. Brace LD. “Cardiovascular benefits of garlic (Allium sativum L),” J Cardiovasc Nurs. 2002 Jul;16(4):33-49. Bradamante S, Barenghi L, Viaa A. “Cardiovascular protective effects of resveratrol,” Cardiovasc Drug Rev. 2004 Fall;22(3):169-88. Chen ZY, Peng C, Jiao R, Wong YM, Yang N, Huang Y. “Anti-hypertensive nutraceuticals and functional foods,” J Agric Food Chem. 2009 Jun 10;57(11):4485-99. Cheng M, Gao HQ, Xu L, Li BY, Zhang H, Li XH. “Cardioprotective effects of grape seed proanthocyanidins extracts in streptozocin induced diabetic rats,” J Cardiovasc Pharmacol. 2007 Nov;50(5):503-9. Cui H, He ZY. “Effects of dry red wine on experimental atherosclerosis in rabbits,” Zhonghua Yu Fang Yi Xue Za Zhi. 2004 Mar;38(2):103-6. Deng R. “Therapeutic effects of guggul and its constituent gullulsterone: cardiovascular benefits,” Cardiovasc Drug Rev. 2007 Winter;25(4):375-90. Devi Sampath P, Vijayaraghavan K. “Cardioprotective effect of alpha-mangostin, a xan- thone derivative from mangosteen on tissue defense system against isoproterenol-induced myocardial infarction in rats,” J Biochem Mol Toxicol. 2007;21(6):336-9. Dulloo AG, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M, Chantre P, Vandermander J. “Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans,” Am J Clin Nutr. 1999 Dec;70(6):1040-5. Duncker DJ, Bache RJ “Regulation of coronary blood flow during exercise,” Physiol Rev. 2008 Jul;88(3):1009-86. Fernandez ML, West KL. “Mechanisms by which Dietary Fatty Acids modulate Plasma Lipds,” The Amer Soc for Nutr Sciences J Nutr. 2005 Sep 135:2075-2078.

Fite A, Goua M. “Regulation of adhesion molecule expression in human endothelial and smooth muscle cells by omega-3 fatty acids and conjugated linoleic acids: involvement of the transcription factor NFKB?” Prostaglandins, Leukotrienes and Essential Fatty Acids. 2008 Jan;78(1):33-43. Gebauer SK, Psota TL, Harris WS, Kris-Etherton PM. “N-3 fatty acid dietary recommen- dations and food sources to achieve essentiality and cardiovascular benefits,” Am J Clin Nutr. 2006 Jun;83(6 Suppl):1526S-1535S. Goua, M, Mulgrew S, Frank J, Rees D, Sneddon AA, Wahle KW. “Regulation of adhesion molecule expression in human endothelial and smooth muscle cells by omega-3 fatty acids and conjugated linoleic acids: involvement of the transcription factor NF-kappaB?” Prostaglandins Leukot Essent Fatty Acids. 2008 Jan;78(1):33-43. Hooper, L, Kroon PA, Rimm EB, Cohn JS, Harvey I, Le Cornu KA, Ryder JJ, Hall WL, Cassidy A. “Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of random- ized controlled trials,” Am J Clin Nutr. 2008 Jul;88(1):38-50. Hu FB, Manson JE, Willett WC. “Types of dietary fat and risk of coronary heart disease: a critical review,” J of Amer Col of Nutr. 2001 20(1):5-19. Hu FB, Stampfer MJ, Manson JE, Rimm E, Colditz GA, Rosner BA, Hennekens CH, Willett WC. “Dietary fat intake and the risk of coronary heart disease in women,” N Engl J Med. 1997 Nov 2;337(21):1491-9. Hunter JE, Zhang J, Kris-Etherton PM. “Cardiovascular disease risk of dietary stearic acid compared with trans, other saturated, and unsaturated fatty acids: a systematic review,” Am J Clin Nutr. 2010 Jan;91(1):46-63. Hutfless SM, Ding X, Girota S. “Chocolate and Prevention of Cardiovascular Disease: A Systematic Review,” Nut and Metab. 2006 3:2. Jakobsen MU, O’Reilly EJ, Heitmann BL, Pereira MA, Balter K, Fraser GE, Goldbourt U, Hallmans G, Knekt P, Liu S, Pietinen P, Spiegelman D, Stevens J, Virtamo J, Willett WC, Ascherio A. “Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies,” Am J Clin Nutr 2009 Feb 11; 89:14-25-1432. Khan N, Hadi N, Afaq F, Syed DN, Kweon MH, Mukhtar H. “Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice,” Carcinogenesis. 2007 Jan;28(1):163-73. Knopp RH, Retzlaff BM. “Saturated fat prevents coronary artery disease? An American paradox,” Am J Clin Nutr. 2004 80(5):1102-1103. Lee, JH, O’Keefe JH, Lavie CJ, Harris WS. “Omega-3 fatty acids: cardiovascular benefits, sources and sustainability,” Nat Rev Cardiol. 2009 Dec;6(12):753-8. Leung FP, Yung LM, Laher I, Yao X, Chen ZY, Huant Y. “Exercise, vascular wall and cardio- vascular diseases: an update (Part 1),” Sports Med. 2008 28(12):1009-24. Li, JJ, Gao RL. “Should atherosclerosis be considered a cancer of the vascular wall?” Med Hypotheses. 2005 64(4):694-8. Lin J, Zheng S, Chen A. “Curcumin attenuates the effects of insulin on stimulating hepatic stellate cell activation by interrupting insulin signaling and attenuating oxidative stress,” Lab Invest. 2009 Dec;89(12):1397-409. Liu JJ, Duan RD. “LY294002 enhances boswellic acid-induced apoptosis in colon cancer cells,” Anticancer Res. 2009 aug;29(8):2987-91.

Liu X, Jing L. “Study of roasted liquorice decoction on arrhythmia,”. Zhongguo Zhong Yao Za Zhi. 2007 Dec;32(23):2471-3. Mensink RP, Zock PL, Kester AD, Katan MB. “Effects of dietary fatty acids and carbohy- drates on the ratio of serum total to HDL cholesterol and on serum lips and apolipoproteins: a meta-analysis of 60 controlled triglycerides,” Am J Clin Nutr. 2003 May;77(5):1146-55. Bibliography 347 348 Bibliography Mozaffarian D, Ascherio A, Hu FB, Stampfer MJ, Willett WC, Siscovick DS, Rimm EB. “Interplay between different polyunsaturated fatty acids and risk of coronary heart disease in men,” Circulation. 2005 Jan 18;111(2):157-64. Mozaffarian D, Micha R, Wallace S. “Effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trials,” PLoS Med. 2010 Mar 23;7(3):e1000252. Mozaffarian D, Rimm EB, Herrington DM. “Dietary fats, carbohydrate, and progres- sion of coronary atherosclerosis in postmenopausal women,” Am J of Clin Nutr. 2004 80(5):1175-1184. Myers, J. “Exercise and Cardiovascular Health,” Circulation. 2003 107:e2. Myers J, Prakash M, Froelicher V, etal. “Exercise capacity and mortality among men referred for exercise testing,” N Engl Med. 2002 346:793-801. O’Donovan M, Owen A, Bird SR, Kearney EM, Nevill IM, Jones DW, Woolf-May K. “Changes in cardiorespiratory fitness and coronary heart disease risk factors following 24 wk of moderate- or high-intensity exercise of equal energy cost,” Appl Physiol. 2005 98:1619-1625. Oh K, Hu FB, Manson JE, Stampfer MJ, Willett WC. “Dietary Fat Intake and Risk of Coronary Heart Disease in Women: 20 Years of Follow-up of the Nurses’ Health Study,” Amer. Jour of Epid. 2005 161(7):672-679. Pang X, Zhang YZ, Sung B, Qu W, Lian X, Aggarwal BB, Liu M. “Acetyl-11-keto-beta- boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated antiogenesis,” Cancer Res. 2009 Jul 15;69(14):5893-900. Pinho RA, Araujo MC, Ghisi GL, Benetti M. “Coronary heart disease, physical exercise and oxidative stress,” Arq Bras Cardio. 2010 Apr;94(4):549-55. Rai SK, Sharma M, Tiwari M. “Inhibitory effect of novel diallyldisulfide analogs on HMG- CoA reductase expression in hypercholesterolemic rats: CREB as a potential upstream target,” Life Sci. 2009 Jul 31;85(5-6):211-9. Ramprasath VR, Jones PJ. “Anti-atherogenic effects of resveratrol,” Eur J Clin Nutr. 2010 Jul;64(7):660-8. Richter EA, Ruderman NB. “AMPK and the biochemistry of exercise: implications for human health and disease,” Biochem J. 2009 Mar 1;418(2):261-75. Rimbach G, Melchin M, Moehring J, Wagner AE. “Polyphenols from cocoa and vascular health-a critical review,” Int J Mol Sci. 2009 Nov 20;10(10):4290-309. Ross JS, Stagliano NE, Donovan MJ, Breitbart RE, Ginsburg GS. “Atherosclerosis: a cancer of the blood vessels?” Am J Clin Pathol. 2001 Dec;116 Suppl:S97-107.

Shishodia S, Sethi G, Aggarwal BB. “Curcumin: getting back to the roots,” Ann N Y Acad Sci. 2005 Nov;1056:206-17. Shukla SK, Gupta S, Ojha SK, Sharma SB. “Cardiovascular friendly natural products: a promising approach in the management of CVD,” Nat Prod Res. 2010 May;24(9):873-98. Siri-Tarino PW, Sun Q. Hu FB, Krauss RM. “Saturated fat, carbohydrate, and cardiovascular disease,” Am J of Clin Nutr. 2010 Mar 91(3):502-509. Somova LI, Shode FO, Mipando M. “Cardiotonic and antidysrthythmic effects of oleanolic and ursolic acids, methyl maslinate and uvaol,” Phytomedicine. 2004 Feb;11(2-3):121-9. Stampfer MF, Hu FB, Manson JE, Rimm EB, Willett WC. “Primary prevention of coronary heart disease in women through diet and lifestyle,” N Engl J Med. 2000 Jul 6;343(1):16-22. Szapary PO, Wolfe ML, Bloedon LT, Cucchiara AJ, DerMarderosian AH, Cirigliano MD, Rader DJ. “Guggulipid for the treatment of hypercholesterolemia: a randomized controlled trial,” JAMA. 2003 Aug 13;290(6):765-72. Tripathi YB. “BHUx:a patented polyherbal formulation to prevent hyperlipidemia and atherosclerosis,” Recent Pat Inflamm Allergy Drug Discov. 2009 3(1):49-57. Urizar NL, Liverman AB, Dodds DT, Silva FV, Ordentlich P, Yan Y, Gonzalez FJ, Heyman RA, Mangelsdorf DJ, Moore DD. “A natural product that lowers cholesterol as an antagonist ligand for FXR,” Science. 2002 May 31;296(5573):1703-6. Virtanen JK, Mozaffarian D, Chiuve SE, Rimm EB. “Fish consumption and risk of major chronic disease in men,” Am J Clin Nutr. 2008 Dec;88(6):1618-25. Wang S, Wu D, Matthan NR, Lmon-Fava S, Lecker JL, Lichtenstein AH. “Reduction in dietary omega-6 polyunsaturated fatty acids: eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouse,” Atherosclerosis. 2009 May;204(1):147-55. Yu Bz, Kaimal R, Bai S, El Sayed KA, Tatulian SA, Apitz RJ, Jain MK, Deng R, Berg OG. “Effect of guggulsterone and cembranoids of Commiphora mukul on pancreatic phospholipase A(2): role in hypocholesterolemia,” J Nat Prod. 2009 Jan;72(1):24-8. Yung LM, Laher I, Yao X, Chen ZY, Huang Y, Leung FP. “Exercise, vascular wall and cardio- vascular diseases: an update (part 2),” Sports Med. 2009 39(1):45-63. CANCER Abdel-Latif MM, Kelleher D, Reynolds JV. “Potential role of NF-kappaB in esophageal adenocarcinoma: as an emerging molecular target,” J Surg Res. 2009 May 1;153(1):172-80. Ahmed KM, Cao N, Li JJ. “HER-2 and NF-kappaB as the targets for therapy-resistant breast cancer,” Anticancer Res. 2006 Nov-Dec;26(6B):4235-43. Aranha MM, Borralho PM, Ravasco P, Moreira da Silva IB, Correia L, Fernandes A, Camilo ME, Rodrigues CM. “NF-kappaB and apoptosis in colorectal tumourigenesis,” Eur J Clin Invest. 2007 May;37(5):416-24. Aviello G, Abenavoli L, Borrelli F, Capasso R, Izzo AA, Lembo F, Romano B, Capasso F. “Garlic: empiricism or science?” Nat Prod Commun. 2009 Dec;4(12):1785-96. Bibliography 349

350 Bibliography Baur JA, Sinclair DA. “Therapeutic potential of resveratrol: the in vivo evidence,” Nat Rev Drug Discov. 2006 Jun;5(6):493-506. Bernstein L, Henderson BE, Hanisch R, Sullivan-Halley J, Ross RK. “Physical exer- cise and reduced risk of breast cancer in young women,” J Natl Cancer Inst. 1994 Sep 21;86(18):1403–1408. Berquin IM, Edwards IJ, Chen YQ. “Multi-targeted therapy of cancer by omega-3 fatty acids,” Cancer Lett. 2008 Oct 8;269(2):363-77. Bode, Ann. “Dietary Ginger may work against cancer growth,” Science Daily. 2003 Oct 29. Bourre JM. “Dietary omega 3 fatty acids for women,” Biomed Pharmacother. 2007 Feb-Apr;61(2):105-12. Campbell KL, McTiernan A. “Exercise and Biomarkers for Cancer Prevention Studies,” J Nutr 2007 137:161S-169S. Cheng AL, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, Ko JY, Lin JT, Lin BR, Ming-Shiang W, Yu HS, Jee SH, Chen GS, Chen TM, Chen CA, Lai MK, Pu YS, Pan MH, Wang YJ, Tsai CC, Hsieh CY. “Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions,” Anticancer Res 2001. 21:2895-2900. Corbetta S, Vicentini L, Ferrero S, Lania A, Mantovani G, Cordella D, Beck-Peccoz P, Spada A. “Activity and function of the nuclear factor kappaB pathway in human parathyroid tumors,” Endocr Relat Cancer. 2005 Dec;12(4):929-37. Dai Y, Lawrence TS, Xu L. “Overcoming cancer therapy resistance by targeting inhibitors of apoptosis proteins and nuclear factor-kappa B,” Am J Transl Res. 2009 1(1):1-15. Dai Y, Liu M, Tang W, Li Y, Lian J, Lawrence TS, Xu L. “A Smac-mimetic sensitizes prostate cancer cells to TRAIL-induced apoptosis via modulating both IAPs and NF-kappaB,” BMC Cancer. 2009 Nov 6;9:392. Denkins J. “Role of Omega-3 PUF on COX-2 metabolism in brain metastatic melanoma,” J. Lipid Res. 2005 Jun v46.no6;1278-84. Dong Z. “Molecular mechanism of the chemopreventive effect of resveratrol,” Mutat Res. 2003 Feb-Mar;523-524:145-150. Escarcega RO, Fuentes-Alexandro S, Garcia-Carrasco M, Gatica A, Zamora A. “The transcription factor nuclear factor-kappa B and cancer,” Clin Oncol (R Coll Radiol). 2007 Mar;19(2):154-61. Fintor L. “Exercise and Breast Cancer Risk: Lacking Consensus,” NCI Jour of the Nat Can Instit. 1999 91(10):825-827. Flavin DF. “A lipoxygenase inhibitor in breast cancer brain metastases,” J Neurooncol. 2007 Mar;82(1):91-3. Fradet V. “Dietary Omega-3 fatty acids COX-2 genetic variation and aggressive prostate cancer risk,” Clin Can Res. March 2009. Gilmore, TD. “Multiple myeloma:lusting for NF-kappaB,” Cancer Cell. 2007 Aug;12(2):95-7.

Gombos K, Zele E, Kiss I, Varjas T, Puskas L, Kozma L, Juhasz F, Kovacs E, Szanyi I, Ember I. “Characterization of microarray gene expression profiles of early stage thyroid tumours,” Cancer Geromics Proteomics. 2007 Nov-Dec;4(6):403-9. Guiterrez-Orozco F, Stephens BR, Neilson AP, Green R, Ferruzzi MG, Bomser JA. “Green and Black tea inhibit cytokine-induced Il-8 production and secretion in AGS gastric cancer cells via inhibition of NFkappaB activity,” Planta Med. 2010 May 26. Haefner B. “Targeting NF-kappaB in anticancer adjunctive chemotherapy,” Cancer Treat Res. 2006 130:219-245. Hewamana S, Alghazal S, Lin TT, Clement M, Jenkins C, Guzman ML, Jordan CT, Neelakantan S, Crooks PA, Burnett AK, Pratt G, Fegan C, Rowntree C, Brennan P, Pepper C. “The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target,” Blood. 2008 May 1;111(9):4681-9. Hsieh TC, Wu, JM. “Resveratrol: Biological and pharmaceutical properties as anticancer molecule,” Biofactors. 2010 Jul 7. Hsu YL, Wu LY, Hou MF, Tsai EM, Lee JN, Liang HL, Jong YJ, Hung CH, Kuo PL. “Glabridin, an isoflavan from licorice root, inhibits migration, invasion and angiogenesis of MDA-MB-231 human breast adenocarcinoma cells by inhibiting focal adhesion kinase/Rho signaling pathway,” Mol Nutr Food Res. 2010 Jul 12. Huang S, Robinson JB, Deguzman A, Bucana CD, Fidler IJ. “Blockade of nuclear factor- kappaB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8,” Cancer Res. 2000 Oct 1;60(19):5334-9. Hung SH, Shen KH, Wu CH, Liu CL, Shih YW. “Alpha-mangostin suppresses PC-3 human prostate carcinoma cell metastasis by inhibiting matrix metalloproteinase-2/9 and uro- kinase-plasminogen expression through the JNK signaling pathway,” J Agric Food Chem. 2009 Feb 25;57(4):1291-8. Ichikawa H, Aggarwal BB. “Guggulsterone inhibits osteoclastogenesis induced by recep- tor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB ctivation,” Clin Cancer Res. 2006 Jan 15;12(2):662-8. Jackson L, Evers BM. “Chronic inflammation and pathogenesis of GI and pancreatic can- cers,” Cancer Treat Res. 2006 130:39-65. Jin X, Wang Z, Qiu L, Zhang D, Guo Z, Gao Z, Deng C, Wang F, Wang S, Guo C. “Potential biomarkers involving IKK/RelAsignal in early stage non-small cell lung cancer,” Cancer Sci. 2008 Mar;99(3):582-9. Jing Y. “Boswellic acid acetate induces differentiation and apoptosis in leukemia cell lines,” Leuk Res. 1999 Jan 23(1):43-50. Bibliography 351 352 Bibliography Kalra N, Seth K, Prasad S, Singh M, Pant AB, Shukia Y. “Theaflavins induced apoptosis of NNCaP cells is mediated through induction of p53, down-regulation of NF-kappa B and mitogen-activated protein kinases pathways,” Life Sci. 2007 May 16;80(23):2137-46.

Kasibhatla S and Tseng B. “Why Target Apoptosis in Cancer Treatment?” Mol Cancer Ther June 2003 2:573-580 Kenfield S, Meir J, Stampfer M, Giovannucci E and Chan J. “Physical Activity and Survival After Prostate Cancer Diagnosis in the Health Professionals Follow-Up Study,” J Clin Oncol. 2011 February 20; 29(6): 726–732. Khan N, Hadi N, Afaq F, Syed DN, Kweon MH, Mukhtar H. “Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice,” Carcinogenesis. 2007 Jan;28(1):163-73. Koschmieder S, D’Alo F, Radomska H, Schoneich C, Chang JS, Konopleva M, Kobayahi S, Levantini E, Suh N, Di Ruscio A, Voso MT, Watt JC, Santhanam R, Sargin B, Kantarjian H, Andreeff M, Sport MB, Perrotti D, Berdel WE, Muller-Tidow C, Serve H, and Tenen DG. “CDDO induces granulocytic differentiation of myeloid leukemic blasts through trans- lational up-regulation of p42 CCAAT enhancer-binding protein alpha,” Blood. 2007 Nov 15;110(10):3695-3705. Kraft TE, Parisotto D, Schempp C, Efferth T. “Fighting cancer with red wine? Molecular mechanisms of resveratrol,” Crit Rev Food Sci Nutr. 2009 Oct;49(9):782-99. Kucharczak J, Simmons MJ, Fan Y, Gelinas C. “To be, or not to be: NF-kappaB is the answer—role of Rel/NF-kappaB in the regulation of apoptosis,” Oncogene. 2003 Dec 8;22(56):8961-82. Kundu JK, Surh YJ. “Molecular basis of chemoprevention by resveratrol: NF-kappaB and AP-1 as potential targets,” Mutat Res. 2004 Nov 2;555(1-2):65-80. Kundu JK, Shin YK, Surh YJ. “Resveratrol modulates phorbol ester-induced pro-inflamma- tory signal transduction pathways in mouse skin in vivo: NF-kappaB and AP-1 as prime targets,” Biochem Pharmacol. 2006 Nov 30;72(11):1506-15. Kundu JK, Shin YK, Kim SH, Surh YJ. “Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity,” Carcinogenesis. 2006 Jul;27(7):1465-74. Kundu JK, Surh YJ. “Inflammation: gearing the journey to cancer,” Mutat Res. 2008 Jul- Aug;659(1-2): 15-30. Kunnumakkara AB, Guha S, Krishnan S, Diagaradjane P, Gelovani J, Aggarwal BB. “Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pan- creatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products,” Cancer Res. 2007 Apr 15;67(8):3853-61. Kwon GT, ChoHJ, Chung WY, Park KK, Moon A, Park JH. “Isoliquiritigenin inhibits migra- tion and invasion of prostate cancer cells: possible mediation by decreased JNK/AP-1 signaling,” J Nutr Biochem. 2009 Sep;20(9):663-76. Lambert JD, Elias RJ. “The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer prevention,” Arch Biochem Biophys. 2010 June 15. Landis-Piwowar K, Chen D, Chan TH, Dou QP. “Inhibition of catechol-Omicron-meth- yltransferase activity in human breast cancer cells enhances the biological effect of the green tea polyphenol (-)-EGCG,” Oncol Rep. 2010 Aug;24(2):563-9. Leleu X, Eeckhoute J, Jia X, Roccaro AM, Moreau AS, Farag M, Sacco A, Ngo HT, Runnels J, Melhem MR, Burwick N, Azab A, Azab F, Hunter Z, Hatjiharissi E, Carrasco

DR, Treon SP, Witzig TE, Hideshima T, Brown M, Anderson KC, Ghobrial IM. “Targeting NF-kappaB in Waldenstrom macroglobulinemia,” Blood. 2008 May 15;111(10):5068-77. Lessard L, Karakiewicz PI, Bellon-Gagnon P, Alam-Fahmy M, Ismail HA, Mes-Masson AM, Saad F. “Nuclear localization of nuclear factor-kappaB p65 in primary prostate tumors is highly predictive of pelvic lymph node metastases,” Clin Cancer Res. 2006 Oct 1;12(19):5741-5. Levidou G, Saetta AA, Korkolopoulou P, Papanastasiou P, Gioti K, Pavlopoulos P, Diamantopoulou K, Thomas-Tsagli E, Xiromeritis K, Patsouris E. “Clinical significance of nuclear factor (NF)-kappaB levels in urothelial carcinoma of the urinary bladder. Virchows Arch,” 2008 Mar;452(3):295-304. Link A, Balaguer F, Goel A. “Cancer chemoprevention by dietary polyphenols: promising role for epigenetics,” Biochem Pharmacol. 2010 Jun 26. Luo JL, Kamata H, Karin M. “IKK/NF-kappaB signaling: balancing life and death—a new approach to cancer therapy,” J Clin Invest. 2005 Oct; 115(10):2625-32. Lv N. “Guggulsterone a plant sterol, inhibits NFKB activation and protects pancreatic beta cells from cytokine toxicity,” Mol Cell Endocrinol. 2008 July 16:289(1-2):49-59. Mantovani A, Marchesi F, Porta C, Sica A, Allavena P. “Inflammation and cancer: breast cancer as a prototype. Breast,” 2007 Dec;16 Suppl 2:S27-33. Manu, KA, Kuttan G. “Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-kappaB mediated activation of bcl-2 in B16F-10 melanoma cells,” Int Immunopharmacol. 2008 Jul;8(7):974-81. Medwire News. “Exercise lowers risk for death in prostate cancer patients,” Dec 9, 2009. Mikstacka R, Ignatowicz E. “Chemopreventive and chemotherapeutic effect of trans- resveratrol and its analogues in cancer,” Pol Merkur Lekarski. 2010 Jun 28(168):496-500. Morais C, Healy H, Johnson DW, Gobe G. “Inhibition of nuclear factor kappaB attenuates tumour progression in an animal model of renal cell carcinoma,” Nephrol Dialysis Trans 2010 25(5):1462-1474. Motadi LR, Misso NL, Diamini Z, Bhoola KD. “Molecular genetics and mechanisms of apoptosis in carcinomas of the lung and pleura: therapeutic targets,” Int Immunopharmacol. 2007 Dec 20;7(14):1934-47. Bibliography 353 354 Bibliography Nishihara R. “Cancer chemopreventive effects and cytotoxic activities of the triterpene acids from the resin of Boswellia carteri,” Biol Pharm Bull. 2006 Sep;29(9):1976-9. Norat T et al. “Meat, Fish, and Colorectal Cancer Risk: The European Prospective Investigation into Cancer and Nutrition,” JNCI J Natl Cancer Inst (15 June 2005) 97 (12): 906-916. Olivier S, Robe P, Bours V. “Can NF-kappaB be a target for novel and efficient anti-cancer agents?” Biochem Pharmacol. 2006 Oct 30;72(9):1054-68.

Oya M, Takayanagi A, Horiguchi A, Mizuno R, Ohtsubo M, Marumo K, Shimizu N, Murai M. “Increased nuclear factor-kappa B activation is related to the tumor development of renal cell carcinoma,” Carcinogenesis. 2003 Mar;24(3):377-84. Pacifico F, Leonardi A. “NF-kappaB in solid tumors,” Biochem Pharmacol. 2006 Oct 30;7(9):1142-52. Pan S, Tao Z, Wu L, Xiao B, Chen S. “Nuclear factor kappaB/p65 and cyclooxygenase-2 expression and clinic significance in human laryngeal squamous cell carcinoma,” Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Jun;19(12):535-7. Park SY, Lim SS, Kim JK, Kang IJ, Kim JS, Lee C, Kim J, Park JH. “Hexane-ethanol extract of Glycyrrhiza uralensis containing licoricidin inhibits the metastatic capacity of DU145 human prostate cancer cells,” Br J Nutr. 2010 May 21:1-11. Patha, K. “Ursolic acid inhibits STAT3 activation pathway leading to suppression of pro- liferation and chemo sensitization of human multiple myeloma cells,” Mol Can Res. 2007 Sept 5(9):943-55. Paule B, Terry S, Kheuang L, Soyeux P, Vacherot F, de la Taille A. “The NF-kappaB/IL-6 path- way in metastatic androgen-independent prostate cancer: new therapeutic approaches?” World J Urol. 2007 Oct;25(5):477-89. Porta C, Larghi P, Rimoldi M, Totaro MG, Allavena P, Mantovani A, Sica A. “Cellular and molecular pathways linking inflammation and cancer,” Immunobiology. 2009 214(9-10):761-77. Ramdass B, Maliekal TT, Lakshmi S, Rehman M, Rema P, Nair P, Mukherjee G, Reddy BK, Krishna S, Radhakrishna Pillai M. “Coexpression of Notch1 and NF-kappaB signal- ing pathway components in human cervical cancer progression,” Gynecol Oncol. 2007 Feb;104(2):352-61. Roy S, Khanna S, Krishnaraju AV, Subbaraju GV, Yasmin T, Bagchi D, Sen CK. “Regulation of vascular responses to inflammation: inducible matrix metalloproteinase-3 expression in human microvascular endothelial cells is sensitive to anti-inflammatory Boswellia,” Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):653-60. Seki E, Brenner DA. “The role of NF-kappaB in hepatocarcinogenesis: promoter or sup- pressor?” J Hepatol. 2007 Aug;47(2):307-9. Shishodia S. “Gugglsterone inhibits NFKB and 1Kp2 kinase activation, suppresses expres- sion of antapoptotic gene products, and enhances apoptosis,” J Biol Chem. 2004 Nov 5;279(45):47148-58. Shishodia S. “Ursolic acid inhibits NFKB activation induced by carcinogenic agents through suppression of IkBoc kinase and p65 phosphorylatin=correlation with down-regulation of COX2, MMP9 and Cyclin D1,” Can Res. 2003 63(15):4375-83. Sica A, Allavena P, Mantovani A. “Cancer related inflammation: the macrophage connec- tion,” Cancer Lett. 2008 Aug 28;267(2):204-15. Singh S, Khar A. “Biological effects of curcumin and its role in cancer chemoprevention and therapy,” Anticancer Agents Med Chem. 2006 May;6(3):259-70. Smith D, Shimamura T, Barbera S, Bejcek BE. “NF-kappaB controls growth of glioblasto- mas/astrocytomas,” Mol Cell Biochem. 2008 Jan;307(1-2):141-7.

Solinas G, Germano G, Mantovani A, Allavena P. “Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation,” J Leukoc Biol. 2009 Nov;86(5):1065-73. Stanojkovic TP, Konic-Ristic A, Juranic ZD, Savikin K, Zdunic G, Menkovic N, Jadranin M. “Cytotoxic and cell cycle effects induced by two herbal extracts on human cervix carci- noma and human breast cancer cell lines,” J Med Food. 2010 Apr;13(2):291-7. Staudt LM. “The molecular and cellular origins of Hodgkin’s disease,” J Exp Med. 2000 Jan 17;191(2):207-12. Stewart PM, Prescott SM. “Can licorice lick colon cancer?” J Clin Invest. 2009 Apr;119(4):760-3. Sukumaran S, Pittman KB, Patterson WK, Dickson J, Yeend S, Townsend A, Broadbridge V, Price TJ. “A phase I study to determine the safety, tolerability and maximum tolerated dose of green-lipped mussel (Perna canaliculus) lipid extract, in patients with advanced prostate and breast cancer,” Annals of Oncology. Doi:10.1093. Ulrich S, Wolter F, Stein JM. “Molecular mechanisms of the chemopreventive effects of resveratrol and its analogs in carcinogenesis,” Mol Nutr Food Res. 2005 May;49(5):452-61. Wang P, Aronson WJ, Huang M, Zhang Y, Lee RP, Heber D, Henning SM. “Green Tea polyphenols and metabolites in Prostatectomy Tissue: implications for cancer prevention,” Cancer Prev Res (Phila Pa). 2010 Jul 13. Wildera D, Kaus A, Kaltschmidt C, Kaltschmidt B. “Neural stem cells, inflammation and NF-kappaB: basic principle of maintenance and repair or origin of brain tumours?” J Cell Mol Med. 2008 Apr;12(2):459-70. Wolin KY, Yan Y, Colditz GA, Lee I-M. “Physical activity and colon cancer prevention: a meta-analysis,” Brit J of Cancer. 2009 100, 611-616. Bibliography 355 356 Bibliography Wu L, Pu Z, Feng J, Li G, Zheng Z, Shen W. “The ubiquitin-proteasome pathway and enhanced activity of NF-kappaB in gastric carcinoma,” J Surg Oncol. 2008 Apr 1;97(5):439-44. Wu Y, Zhou BP. “Inflammation: a driving force speeds cancer metastasis,” Cell Cycle. 2009 Oct 15;8(20):3267-73. Yang L, Liu X, Lu Z, Yuet-Wa Chan J, Zhou L, Fung KP, Wu P, Wu S. “Ursolic acid induces doxorubicin-resistant HepG2 cell death via the release of apoptosis-inducing factor,” Cancer Lett. 2010 Jul 12. Yeh CT, Wu CH, yen GC. Ursolic acid, a naturally occurring triterpenoid, suppresses migra- tion and invasion of human breast cancer cells by modulating c-Jun N-terminal kinase, Akt and mammalian target of rapamycin signaling. Mol Nutr Food Res. 2010 Mar29. Zahid M, Saeed M, Ali MF, Rogan EG, Cavalieri EL. “N-acetylcysteine blocks forma- tion of cancer-initiating estrogen-DNA adducts in cells,” Free Radic Biol. Med. 2010 Aug 1;49(3):392-400. Zand H, Rahimipour A, Salimi S, Shafiee SM. “Docosahexaenoic acid sensitizes Ramos cells to Gamma-irradiation-induced apoptosis through involvement of PPAR-gamma

activation and NF-kappaB suppression,” Mol Cell Biochem. 2008 Oct;317(1-2):113-20. APPENDIX The Cell Science Behind It All Bagga D, Wang L, Farias-Eisner R, Glaspy J. Reddy ST. “Differential effects of prostaglan- din derived from x-6 and w-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion,” PNAS. 2003 Feb;100(4):1751-56. Bianco FJ, Guitian R, Moreno J, de Toro FJ, Galdo F. “Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes,” J Rheumatol. 1999 26:1366-1373. Cao J, Schwichtenberg KA, Hanson NQ, Tsai MY. Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids. Clin Chem. 2006 Dec;52(12):2265-72. Epub 2006 Oct 19. Champ PC, Harvey, RA. Lippincott’s Illustrated Reviews: Biochemistry 2nd edition. Lippincott Williams & Wilkins, 1994 Chung HY, Kim HJ, Kim JW, Yu BP. “The inflammation hypothesis of aging: molecular modulation by calorie restriction,” Ann NY Acad Sci. 2001 Pri; 928:327-35. Clandinin MT, Foot M,Robson. “Plasma membrane: Can its structure and function be modulated by dietary fat?” Comparative Biochemistry and Physiology Part B: Comparative Biochemistry. 1983: (76) issue 2: 335-339. Fan YY, Ly LH, Barhoumi R, McMurray DN, Chapkin RS. “Dietary docosahexaenoic acid suppresses T cell protein kinase C theta lipid raft recruitment and IL-2 production,” J Immunol. 2004 Nov 15;173(10):6151-60. Goldring, Mary B., Berenbaum, Francis. “The Regulation of Chondrocyte Function by Proinflammatory Mediators,” Clin Ortho and Related Research. 2004 Number 427S, pp. S37-S46. Hellsten Y, Skadhauge L, Bangsbo J. “Effect of ribose supplementation on resynthesis of adenine nucleotides after intense intermittent training in humans,” Am J Physiol Regul Integr Comp Physiol. 2004 Jan: 286 (1): R 182-8. Hwang DH, Chanmugam PS, Ryan DH, Boudreau MD, Windhauser MM, Tulley RT, Brooks ER, Bray GA. “Does vegetable oil attenuate the beneficial effects of fish oil in reducing risk factors for cardiovascular disease?” Am J Clin Nutr. 1997 Jul;66(1):89-96. Kakkar P, Singh BK. “Mitochondria: a hub of redox activities and cellular distress control,” Mol Cell Biochem. 2007 Nov;305(1-2):235-53. Epub 2007 Jun 12. Kris-Etherton PM, Grieger JA, Etherton TD. “Dietary reference intakes for DHA and EPA,” Prostaglandins Leukot Essent Fatty Acids. 2009 Aug-Sep;81(2-3):99-104. Li B, Birdwell C. “Antithetic Relationship of Dietary Arachidonic Acid and EPA on Eicosanoid Production in Vivo,” J Lipid Sea October 1994 35(10A) 1869-77. Li Q, Withoff S, Verma IM. “Inflammation-associated cancer: NF-kappaB is the lynchpin,” Trends Immunol. 2005 Jun;26(6):318-25. Lopez-Armada MJ, Carames B, Martin MA, Cillero-Pastor B, Lires-Dean M, Fuentes- Boquete I, Arenas J. Bianco, FJ. “Mitochondrial activity is modulated by TNFalpha and IL-1beta in normal human chondrocyte cells,” Osteoarthritis Cartilage. 2006 Oct;14(10):1011- 22. Epub 2006 May 5.

MCcAnn SM, Mastronardi C, de Laurentiis A., Rettori V.”The Nitric Oxide Theory of Aging Revisited,” Ann NY Acad Sci. 2005 Dec;1057:64-84. Neelands PJ, Clandinin MT. “Diet fat influences liver plasma membrane lipid composition and glucagon-stimulated adenylate cyclase activity,” Biochem J. 1983: (212): 573-583. Orrenius S. “Reactive oxygen species in mitochondria-mediated cell death,” Drug Metab Rev. 2007;39(2-3):443-55. Orrenius S, Gogvadze V, Zhivotovsky B. “Mitochondrial oxidative stress: implications for cell death,” Ann Rev Pharmacol Toxicol.2007;47:143-83. Ottestad I, Hassani S, Borge GI, Kohler A, Vogt G, Hyo tyla inen T, Ores ic M, Brønner KW, Holven KB, Ulven SM, Myhrstad MC. “Fish Oil Supplementation Alters the Plasma Lipidomic Profile and Increases Long-Chain PUFAs of Phospholipids and Triglycerides in Healthy Subjects,” PLoS One. 2012;7(8):e42550. Epub 2012 Aug 28. Roskoski R Jr, Herbert JD. Biochemistry Review. Saunders, 1996 Sirhan C N, Arita M, Hong S and Gotlinger K. “Resolvins, Docosatrienesx, and Neuroprotectins, Novel Omega-3-Derived Mediators, and Their Endogenous Aspirin- Triggered Epimers,” Lipids. 2004 39 (11) 1125-1132. Bibliography 357 358 Bibliography Takada Y, Bhardwaj A, Potdar P, Aggarwal BB. “Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kabbaB activation, inhibition of expression of cyclo- oxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation,” Oncogene. 2004 Dec 9;23(57):9247-58. Terkeltaub R, Johnson K, Murphy A. Ghosh S. “Invited review: the mitochondrion in osteo- arthritis,” Mitochondrion. 2002 Feb;1(4):301-19. Wilcox RB. High Yield Biochemistry. Lippincott Williams & Wilkins, 1999. Yin MJ, Yamamoto Y, Gaynor RB. “The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa) B kinase-beta,” Nature. 1998 Nov 5;396(6706):77-80.