HEARTWORM DISEASE
• PREVALANCE
• LIFE CYCLE
• DIAGNOSIS
• TREATMENT
TINY• 3 yr old MN Rottweiler
• Treated for heartworm disease last year with Immiticide
• Has had repeated ELISA Ag test negative since then
• How is he now Heartworm Positive?
Origin
• Dirofilaria immitis: first originated in Asia then spread to the Mediterranean countries.
• Brought to the Americas from early explorers and immigrants with their dogs
• Was first reported in the US in a dog from Erie, Alabama
PREVALANCE
From Bowman DD, Susan EL, Lorentzen L, et al. Prevalenceand geographic distribution of Dirofilaria immitis, Borrelia burgdorferi, Ehrlichia canis, and Anaplasma phagocytophilum in dogs in the United States: Results of a national clinic-based serologic survey. Vet Parasitol 2009;160(1/2):138–48
Transmission
• Most common in late summer– July-August
• Reservoir host: domesticated and wild canids• Intermediate hosts: Mosquitos• Felines: tend not to be biologic hosts – Can still become infected
• Other mammals, including humans can acquire nonpatent infections
LIFE CYCLE
LARVAL MIGRATION
Kotani T, Powers KG. Developmental stages of Dirofilaria immitis in the dog. Am J Vet Res1982;43(12):2199–206
DIAGNOSIS
• ANTIGEN TEST: Will detect the presence of adult female worms at least 6 months old
• Microfilaria test: can be present 6 months post-infection but typically by 7-9 months– Less sensitive; especially if on a macrocyclic lactone– Helps to identify patient as a reservoir
• For cats; difficult to detect. If clinical suspicion recommend both antigen and microfilaria test
Diagnosis
• Thoracic Radiographs: Can help evaluate severity of disease
• CBC
• Serum Chemistry: Hemoglobinemia can be seen with caval syndrome
• Urinalysis: Hemoglobinuria can be seen with caval syndrome
Thoracic Radiographs
• Parenchymal PA enlargement, truncation, and/or tortuosity – pulmonary hypertension and/or loss in laminar
blood flow• Peripheral focal or multifocal alveolar
pulmonary pattern – PTE caused by dead adult worm fragments or
secondary eosinophilic pneumonitis
Textbook of Veterinary Diagnositc Radiology, 5th edition. Thrall. 2007, p 583-4
Thoracic Radiographs
• MPA dilation– caused by turbulent blood flow and pulmonary
hypertension and possibly the presence of heartworms
• RV hypertrophy– in response to pulmonary hypertension
• Hepatomegaly, ascites, and occasionally pleural effusion– caused by right-sided heart failure
Textbook of Veterinary Diagnositc Radiology, 5th edition. Thrall. 2007, p 583-4
FELINEFOCAL PATCHY ALVEOLAR PATTERN
L. Venco, Clinical evolution and radiographic findings of felineheartworm infection in asymptomatic cats. Veterinary Parasitology 158 (2008) 232–237
Focal Caudodorsal Oligemiasuggestive of thromboembolism
L. Venco, Clinical evolution and radiographic findings of felineheartworm infection in asymptomatic cats. Veterinary Parasitology 158 (2008) 232–237
Angel: 6yr FS DSH
Right caudal pulmonary artery enlargement
Tiny: 3yr MI Rottie
MPA enlargement, tortuous enlarged pulmonary arteries with normal veinsDiffuse bronchointerstitial pattern
Tiny: Left Lateral
Previously treated for HW 1 year ago; unknown protocol
• Live heartworms: – can cause endarteritis and muscular hypertrophy of
arteriole walls especially in the caudal pulmonary arteries
• Dying/dead HWs: – decompose and small worm fragments lodge in
distal pulmonary arteriole and capillary beds in the caudal lung lobes. Worm fragments with inflammation and platelet aggregation results in PTEs
TREATMENT
• An adult heartworm can live up to 7.5 years• Microfiliaria can live up to 2.5 years in the
blood• Need proper treatment protocols to
eradicate both the larval, juvenile, and adult heartworms
TREATMENT
• Adulticide:Melarsomine(Immiticide)– No activity against worms less than 4 months old
• Larvacide: Macrocyclic lactones– Work against microfilaria, L3, L4 and some young adult
heartworms. Does not work well against later 4th stage and juvenile worms
• Doxycycline: Endosymbiont of D. immitis is a Rickettsial infection of Walbachia– As kill heartworms they can release the Walbachia
• Treating with doxy may help decrease lung pathology
Feline Treatment
• Treatment of Choice:– Surgical removal of worms
• If not clinical may be prudent to not tx– Give prednisone to prevent secondary
inflammation• Immiticide: Not recommended and may be
toxic
TREATMENT GAPS
Image from: www.americanheartwormsociety.org, Heartworm Infection in Dogs
Treatment
• To help with the treatment gap– Treat with 2-3 months of macrocylic lactone first– eliminate the migrating larva less than 2 months
old and allow those worms between 2 and 4 months of age to reach an age at which they are susceptible to immiticide.
• Then give injection of immiticide• 1 month later give second injection• 24 hours later give 3rd injection
TREATMENT OF CAVAL SYNDROME
• Adult heartworms partially obstruct blood flow through the tricuspid valve and interferes with closure– Can then cause passive congestion of the liver. – CS: sudden onset of lethargy, weakness, with
hemoglobinemia and hemoglobinuria. – See on echo: HWs within the tricuspid orifice and
caudal vena cava.
Caval Syndrome Treatment
• If treat with an adulticide– Die off will be numerous and rapid– Likely will lead to pulmonary emboli and severe
inflammatioin– Increased morbidity and mortality
• Need to decrease worm burden surgically first
SURGICAL RETRIEVAL
• Via right jugular vein: pass a flexible alligator forceps or an intravascular retrieval snare under fluoroscopic guidance
Image from: www.americanheartwormsociety.org, Heartworm Infection in Dogs
Caval Syndrome Treatment
• After surgical removal of worms– Murmur should resolve– Hemoglobinuria and hemoglobinemia should
resolve in 12-24 hours
– In a few weeks can continue with normal treatment protocol