Presentationof

Our Qualifications

on

Leadership Solutions

through retained search

Spring 2010

CONTENTS

HPI’s Credentials & Approach

Overview

Applied Spine Tech. - Search Target List

Our Experience Covers the Value Chain

1

2

3

Value Proposition

Client Service Orientation

Geographic Reach

4

5

6

HPI: Best of Both Large and Small Firms

Quality

Your HPI Team

7

8

9

Examples of Completed Work 11

OVERVIEW: WHAT WE DOThe most successful organizations have the most effective leadership teams. The active management of leadership capital has emerged as a critical success factor for all organizations, particularly during times of change and uncertainty. Working with the leadership of global business, we know how to develop and execute comprehensive leadership capital strategies. We help our clients to Acquire, Assess and Develop their top leadership talent.

OverviewHPI’s Credentials

& ApproachQuality &

Fee StructureYour Search

TeamExamples of

Completed Work

                                         

                    

  

                    

             

       

             

       

                    

Service Spotlight

Team Building

From organizational design and benchmarking to recruiting, our consultants have extensive track records including broad functional depth from building Boards and recruiting most line and staff roles – we have completed more than 500 searches during our careers.

Executive Assessment

We help you better understand the capabilities and potential of your leadership team through competency-based assessments of leaders benchmarked against the industry’s talent

Professional Development

We work closely with some of the best consultants in the industry to maximize the performance of individuals and teams through executive coaching and education.

Strategy

Organizational Design

Organizational Benchmarking

RecruitingCoaching/Education

Leadership Development

OrganizationalAssessment

Executive Talent Management Model

Page 1

INITIAL TARGET LISTOverview

HPI’s Credentials & Approach

Quality &Fee Structure

Your Search Team

Examples of Completed Work

Page 2

Abbott Spine Innovative Spinal Tech Replication MedicalAesculap Interventional Spine Smith & NephewAlphatec Isotis Specialized Medical DevicesAngioDynamics K2M SpinematrixArchus Ortho Kyphon SpinewaveB Braun Medical LDR Spine St. Francis Medical (x)Biomet Medtronic Stryker Corpc5 Medical Werks Northstar Neuro Stryker SpineDePuy / J &J Nuvasive Tecomet / ViasysDepuy Spine Orthofix The Cleveland ClinicEndius Osiris The Polymer Tech GroupE-Z-EM Osteobiologics ZimmerInnovasis Raymedica

Initial Target List for

Applied Spine Technologies

Our experience covers the value chain

Over 1,000 successful assignments working with many of the most respected companies in their field from exciting start-ups to titans in their industry

Delivery & Services

PAYORS

• Foundation Health

PROVIDERS

• Atlantic Health System

Government• Battelle Memorial Institute

Private• Harvard Medical School• Janssen

Research & Development Manufacturing

Genomics/ProteomicsCuragen – GeneLogic Oxford Glycosciences454 Corporation - Praecis

BiotechnologyAchillion – Savient – Aegerion – Enzon – Esperion – Eyetech Pharmaceuticals – Exact Sciences Corp- Sopherion – Optherion - Chiron

PharmaceuticalsAstra-Zeneca - Bayer – Bristol Myers Squibb – Kos Pharmaceuticals – Purdue – Sanof/Aventisi – Serono

- Baxter – Boston Scientific – Fischer Scientific International – Home Diagnostics Inc.- Roche Diagnostics – Kinetic Concepts, Inc. – Songbird Hearing – Tengion – Histogenics - HistoRx

Medical Devices & Diagnostics

Biovail – Endo Pharmaceuticals – Geneva – Ivax – Teva

Generic Drugs

Enzon – Emisphere Technologies – Drug Delivery

• Express Scripts• McKesson• Medco

Sales/MarketingDistribution

• Applied Analytical• Cambrex•Cobra•Sharp Corp.

Edelman PR

Page 3

OverviewHPI’s Credentials

& ApproachQuality &

Fee StructureYour Search

TeamExamples of

Completed Work

• “Top End” boutique with hand-picked alumni from top-tier global consulting firms including Heidrick & Struggles, Spencer Stuart and Russell Reynolds where our partners average 14 years of search experience

– Former global head of Heidrick’s Healthcare Practice

– Former Office Managing Partner for Spencer’s Brussels office

• Industry Depth – from co-founding biotech start-ups to management roles with Bayer, Aventis, Novartis, Pfizer and Johnson & Johnson, we walk the walk

• We are a New Haven headquartered Life Science-only international recruiting firm with extensive “Top 5” global experience

• More than 1,000 assignments conducted

• Significant experience in medical devices and marketing assignments to include recent ortho experience with start-ups and large companies (e.g. Zimmer)

•Extensive start-up experience (approximately 25% of our work)

•Deep experience in most functions including: General Management, marketing, Finance, R&D, Operations, Sales and Business Development

•We know the talent and have the needed access

Heritage Partners’ Value Proposition

Page 4

OverviewHPI’s Credentials

& ApproachQuality &

Fee StructureYour Search

TeamExamples of

Completed Work

Our objectives are well defined:

• We seek to identify the best talent available for any position

• To create value for you, our client

• To deliver a productive, fast and smooth search experience

Our Approach is better:

• We believe we have a better process using the best resources available including people and technology. We typically “double up” on resources from the outset, enabling faster speed to identify the right candidates. We work on fewer searches at a time than most firms because we want to remain responsive and nimble.

• We are selective about who we will work with, and so we maintain tight control to avoid off-limits issues

Client Service Orientation

OverviewHPI’s Credentials

& ApproachQuality &

Fee StructureYour Search

TeamExamples of

Completed Work

Page 5

GEOGRAPHIC REACH

With our affiliation with Whitehead Mann, we have conducted well over 1,000 search assignments globally.

We are strategically located in the northeastern United States and Europe – thus giving us strong access to the talent.

This structure allows us to be as responsive as a boutique firm yet serve our clients with the support of a US/European partnership.

ColoradoCT

NY

Hong Kong

New Delhi

Mumbai

NJPA

Sao Paolo

Johannesburg

LeedsBirmingham

London

Frankfurt

Brussels

Key:

Heritage Partners International Offices

Whitehead Mann Offices

OverviewHPI’s Credentials

& ApproachQuality &

Fee StructureYour Search

TeamExamples of

Completed Work

Page 6

HPI’s positioning combines the best of Local and Global Firms

Regional Boutiques

• Often dependent on one person

• Regional focus, limited ability to attract nationally or internationally due to lack of market knowledge

• Limited breadth of search due to relationship focus

• Typically operate without world-class supporting processes and technology

Large Global Firms

Closeness to markets and customer

Senior partners active in all searches

Little/no off-limits

• May lack flexibility and speed of execution• Processes and communication across borders awkward• Bait and switch common• Database driven more than market assessment• Off-limits

Global Reach

Board service offerings

Candidate knowledge and access

Infrastructure (technology/research, etc.)

OverviewHPI’s Credentials

& ApproachQuality &

Fee StructureYour Search

TeamExamples of

Completed Work

Page 7

Our Commitment to Quality

Extensive Life Sciences industry and Human Capital experience

Integrated Database, independently developed and managed

Process is speed-centric. Our goal is to complete assignments in < 3 months

Key partners have lived/worked in Europe and

Latin America

Global Reach in Partnership with Whitehead Mann – the 6th largest executive search firm in the world

Our teams

Processes and Technology

Speed & Accuracy

International

OverviewHPI’s Credentials

& ApproachQuality &

Fee StructureYour Search

TeamExamples of

Completed Work

Page 8

Kevin M. Butler

Kevin Butler is a co-founder and the President and Managing Partner of Heritage Partners International (HPI), a retainer-based, human capital strategy consultancy with offices in Philadelphia, New Haven and Morristown. Mr. Butler is based in New Haven and concentrates primarily on senior-level life sciences searches and other related human capital issues. During the past 13 years, he has served a broad range of pharmaceutical, biotech and medical device clients around the globe. He has successfully recruited hundreds of non-executive Directors, Chief Executive Officers, Chief Operating Officers and Vice Presidents in most line and staff functions for clients ranging from major multinationals to venture-backed start-ups.

Prior to starting HPI, he was the Global Managing Partner for Heidrick & Struggles’ Health Care Practice. Earlier he led the Global Medical Device and Diagnostics Practice at Spencer Stuart. Mr. Butler began his search career with Russell Reynolds where he started and led their Healthcare Information Technology Practice. Before entering search, he had executive roles with Pfizer and Johnson & Johnson, and was a strategic management consultant with Marakon Associates and Dynamics Research Corporation.

Mr. Butler spent 8 years on active duty in the US Army as an Armor, Cavalry and Infantry officer serving around the world. A native of Massachusetts, Kevin is a graduate of The US Military Academy at West Point where he received a B.S. in Engineering. He received an MBA from The Wharton School at The University of Pennsylvania.

OverviewHPI’s Credentials

& ApproachQuality &

Fee StructureYour Search

TeamExamples of

Completed Work

Page 9

Tig Conger

Tig Conger is a partner in Heritage Partners International's New Haven, CT office.  He joined the firm in 2004 following a successful 20 year career in commercial operations with Searle, Aventis and Bayer where he was responsible for the successful management of major product launches in a number of therapeutic areas both in the U.S. and Europe.  At HPI his work is focused on pharmaceutical and biotechnology companies with particular expertise in sales and marketing assignments.

Most recently he was Vice President of Marketing for Bayer's U.S. Pharmaceutical Division where he was responsible for Anti-Infective and Hospital products and previously their cardiovascular products.   At Aventis, Tig was Director of Marketing for Cardiovascular and Allergy products and responsible for the development and management of several strategic alliances. Tig's consulting career began at Hayes/Hill where he was a Senior Associate in the strategy practice.

Tig is a member of the Board of Trustees for the National Foundation for Infectious Diseases.

Mr. Conger is a graduate of Tulane University where he received a B.S. in Engineering.  He received an MBA from Columbia Business School.  He resides in Milford, Connecticut with his wife Kathy and their four children.

OverviewHPI’s Credentials

& ApproachQuality &

Fee StructureYour Search

TeamExamples of

Completed Work

Page 10

Representative Search Experiences

OverviewHPI’s Credentials

& ApproachQuality &

Fee StructureYour Search

TeamExamples of

Completed Work

Page 11

Big Pharma

Company Position

Astra Zeneca Vice President, Discovery Research

Executive Director, Medical Affairs

Senior Director, Quality Assurance

Bayer Pharmaceuticals Chief Scientific Officer

Sr. Vice President, Oncology

Vice President, Marketing Oncology

Director of Clinical Pharmacology

Director of Global e-Business

Bayer Diabetes President, Diabetes Care Division

Chief Financial Officer

Vice President Sales

Bayer Consumer Care Division SVP, Chief Scientific Officer

VP, Global Medical Affairs and Clinical Research

Boehringer Ingelheim Director, Medical Affairs OTC

Director, Drug Safety (x2)

Representative Search Experiences

OverviewHPI’s Credentials

& ApproachQuality &

Fee StructureYour Search

TeamExamples of

Completed Work

Page 12

Big Pharma - continued

Company Position

Pharmacia Director, Clinical Development

Director, Talent Management

Sanofi General Manager, Oncology

Vice President, Medical Urology

Vice President, Managed Care

Vice President, New Product Development

Senior Director, Marketing

Representative Search Experiences

OverviewHPI’s Credentials

& ApproachQuality &

Fee StructureYour Search

TeamExamples of

Completed Work

Page 13

Bio Pharmaceutical

Company Position

ABC Laboratories Chief Executive Officer

Achillion Pharmaceutical Chief Operating Officer

Chief Financial Officer

Boston Life Sciences Clinical Director, Neurology

Clinical Director, Oncology

Director, Regulatory Affairs

CuraGen Chief Executive Officer

Board Member (2)

Elusys Vice President, Finance

Emisphere Technologies Board Member

Chief Operating Officer

Director, Marketing

Director, Information Systems

Enzon Board of Director

Chief Executive Officer

Vice President, Controller

Representative Search Experiences

Page 14

OverviewHPI’s Credentials

& ApproachQuality &

Fee StructureYour Search

TeamExamples of

Completed Work

BioPharmaceutical – cont’d

Company Position

Exact Sciences Board Member

Chief Financial Officer

Iomai Vice President, Business Development

Histogenics Chief Executive Officer

HistoRX Vice President, Sales & Business Development

The Jackson Laboratory Associate General Manager, Product Development

MMRF/RC President

Mojave Therapeutics Chief Scientific Officer

Oxford Glycosciences Chief Operating Officer

Vice President, Commercial Operations

Vice President, Research & Development

Optherion Chief Executive Officer

Chief Financial Officer

Paratek Pharmaceuticals Chief Financial Officer

Praecis Pharmaceuticals Senior Vice President, Technology Partnerships

Serono Senior Vice President, Neurology Vice President, Neurology Sales

Representative Search Experiences

Page 15

OverviewHPI’s Credentials

& ApproachQuality &

Fee StructureYour Search

TeamExamples of

Completed Work

BioPharmaceutical – cont’d

Company Position

Sopherion Therapeutics Chief Executive Officer

Chief Financial Officer

Talecris Director, Marketing

Tengion Chief Executive Officer

Chief Financial Officer

Vice President, Manufacturing

Vice President, Business Development

Vice President, Science & Technology

Vice President, Process Research

Vice President, Quality Assurance

Vion Chief Financial Officer

ViroPharma Chief Scientific Officer

Representative Search Experiences

Page 16

OverviewHPI’s Credentials

& ApproachQuality &

Fee StructureYour Search

TeamExamples of

Completed Work

Specialty Pharma

Company PositionAegerion Vice President, Regulatory Affairs

Biovail Vice President, Managed Care

Vice President, Manufacturing

Cambrex Chief Executive Officer

Eyetech Chief Financial Officer

Ivax Pharmaceuticals Vice President, Development – Europe

Kos Pharmaceuticals Vice President, Business Development

Director, Medical Affairs

Purdue Pharma Vice President, Corporate Security

Executive Director – Quality Assurance

Executive Director – Corporate Compliance

Senior Director, Manufacturing Compliance

Savient Pharmaceuticals Board Member

Vice President, Sales

Teva Pharmaceuticals Chief Financial Officer

Vice President, Human Resources – North America

Senior Vice President, Finance and Business Development

GM- TSP Head of Respiratory

Director, Communications

Representative Search Experiences

Page 17

OverviewHPI’s Credentials

& ApproachQuality &

Fee StructureYour Search

TeamExamples of

Completed Work

Devices

Company Position

Bausch & Lomb Category Leader

Category Leader

Baxter Health Care Vice President, Manufacturing

Vice President, Supply Chain

454 Life Sciences Chief Executive Officer

Vice President, Marketing

Director, Marketing

Fisher Healthcare Vice President, Marketing

Kinetic Concepts Chief Executive Officer

Division President

Vice President, Sales Operations

Vice President, Research & Development

Smith Industries, PLC Managing Director, Life Sciences

Songbird Hearing Chief Executive Officer

Thermo Electron Vice President, Marketing

Zimmer Board Members (3)

Representative Search Experiences

OverviewHPI’s Credentials

& ApproachQuality &

Fee StructureYour Search

TeamExamples of

Completed Work

Page 18

Service Companies

Company Position

Cobra BioManufacturing Global Head, Business Development

Director Sales, Eastern Region

Director Sales, Western Region

Edelman Worldwide President, International

Managing Director, UK

International Business Director, Healthcare

Institute for Cancer Prevention Chief Development Officer

Parexel Consulting Vice President, North American Account Management

PHT Laboratories Chief Executive Officer and President

Rexam Medical Packaging President, North America

SCA Chief Financial Officer

Vice President, Human Resources

Representative Search Experiences

OverviewHPI’s Credentials

& ApproachQuality &

Fee StructureYour Search

TeamExamples of

Completed Work

Page 19

Technology Platforms

Company Position

Aderis Pharmaceuticals Vice President, Medical Affairs

Director, Business Development

Althexis Chief Executive Officer and President

Alkermes Vice President, Medical Affairs

Genelabs Vice President, Business Development

Impath Laboratories Board Member

Representative Search Experiences

OverviewHPI’s Credentials

& ApproachQuality &

Fee StructureYour Search

TeamExamples of

Completed Work

Page 20

Other

Company Position

Barnev Chief Executive Officer

Empower Health (VC) Chief Financial Officer

Innomed Ventures (VC) General Partner

Schroder Ventures General Partner

Sharp (VC) Chief Executive Officer

SSG (VC) Chief Operating Officer

Chief Financial Officer