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High-Impact Research to Change Lives
High-Impact Research to Change Lives
LEARNING OBJECTIVES
Participants should leave energized by progress occurring in MS research, and should be able to inspire others by explaining in simple terms several promising areas of research and the Society’s role in driving progress
Stop, Restore, End – For Everyone with MS• Finding Solutions for people with MS is Our Highest
Priority -- Research is essential to changing lives• We’ve invested nearly $870 million in research since
1947, contributing to many of the FDA-approved therapies
• We’re fueling research through increased investment – 2014: $50.6 million for 380 new/ongoing projects – 2015: $51+ million
• We now lead the way, funding more research and impacting more lives than any other MS organization in the world
EnvironmentalTrigger
Autoimmunity
GeneticPredisposition
What Causes MS?
Loss of myelin & nerve fibers
MS Interrupts the Flow of Information Between the Brain and the Body
Functional nerve cell
Nerve cell with MS damage
Stop, Restore, End• STOP -- Understand immune activity, progression,
accelerate new therapies, discover how myelin and nerve cells are damaged and how to protect them
• RESTORE -- Myelin repair, rehab, exercise, symptomatic therapies
• END -- Identify risk and triggering factors, such as genes and lifestyle factors, for prevention
– Follow all promising paths, with three priority areas: Progressive MS, Nervous System Repair, Wellness/Lifestyle
Multiyear Awards by Research Goals
STOP
$79M
END $9M
199147
19
RE-STORE$50M
380 active projects
Research Strategies• Comprehensive and Collaborative
– Pursue all promising paths, wherever they exist– Expand/strengthen MS research globally– Remain nimble to seize promising new
opportunities• Investigator-initiated and targeted• Centralized peer review, funding and stewardship• Fund worldwide – no boundaries
Research Strategies (cont.)• Basic and translational investigations• Foster collaboration, interdisciplinary approaches• Support shared resources (ie tissue and DNA banks) • Training awards to attract and keep scientists and
physicians focusing on MS• Commercial drug development partnerships
to speed therapies• Think tanks and workshops to identify gaps and
opportunities, e.g. this week’s Wellness Strategy Mtg.
Driving Solutions
1993 Betaseron
2013 Skin stem cells myelinate mouse brain – human trials planned
1996 Research shows exercise helps MS
1981 First MRI scans revolutionize diagnosis
2010 First oral MS therapy
2002 Demonstrated benefit of sex hormone estriol leads to large trial
1996-2014 Ten more approved therapies
1989 Natural myelin repair demonstrated
1992 First research on exercise in MS
1965 Society convenes panel to improve MS diagnosis
2004 Link: vitamin D intake and MS risk
2009 New evidence that early treatment delays progression
1947 1965 1980 1995 2010 2014
$7M
$868M cumulative research investment
1980 1st int’l conference on trials creates path for MS therapies
1998 Targeted initiative into gender differences in MS
$49M
$186
M
$686
M
2010 First drug to improve walking
2005 Nervous System Protection & Repair Initiative jumpstarts field
2012 Progressive MS Alliance launched
2003 Smoking reported as a modifiable risk factor for MS
2007 Society convenes Stem Cell Summit